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Image Guided Radiotherapy

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https://www.readbyqxmd.com/read/29221676/prospective-medical-analysis-of-radiation-therapist-image-repositioning-during-image-guided-radiotherapy
#1
O Lauche, F Castan, H de Forges, C Guillaumon, S Gourgou, P Fenoglietto, N Aillères, D Azria, O Riou
PURPOSE: Radiation oncologists are responsible for deciding which day-to-day variations are acceptable or not in the treatment setup. However, properly qualified and trained radiation therapists might be capable to perform image registration. We evaluated in our centre the capability and accuracy of radiation therapists to validate positioning images in a prospective study. METHODS AND PATIENTS: A total of 84 patients treated for prostate, head and neck, lung or breast cancer was prospectively and randomly included from July 2011 to July 2013 in radiotherapy unit of our institution...
December 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29218271/magnetic-resonance-imaging-in-precision-radiation-therapy-for-lung-cancer
#2
REVIEW
Hannah Bainbridge, Ahmed Salem, Rob H N Tijssen, Michael Dubec, Andreas Wetscherek, Corinne Van Es, Jose Belderbos, Corinne Faivre-Finn, Fiona McDonald
Radiotherapy remains the cornerstone of curative treatment for inoperable locally advanced lung cancer, given concomitantly with platinum-based chemotherapy. With poor overall survival, research efforts continue to explore whether integration of advanced radiation techniques will assist safe treatment intensification with the potential for improving outcomes. One advance is the integration of magnetic resonance imaging (MRI) in the treatment pathway, providing anatomical and functional information with excellent soft tissue contrast without exposure of the patient to radiation...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218269/blood-based-biomarkers-for-precision-medicine-in-lung-cancer-precision-radiation-therapy
#3
REVIEW
Dirk De Ruysscher, Jianyue Jin, Tim Lautenschlaeger, Jin-Xiong She, Zhongxing Liao, Feng-Ming Spring Kong
Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are being unraveled. Multiple techniques, including histological examination, blood sampling, measurement of circulating tumor cells (CTCs), and functional and molecular imaging, can be used for this purpose...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29217331/dosimetric-impact-of-translational-and-rotational-setup-errors-for-spine-stereotactic-body-radiotherapy-a-phantom-study
#4
Makoto Sasaki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Manabu Nakata, Masahiro Hiraoka
This study aimed to investigate experimentally the effect of translational and rotational setup errors on 3-dimensional dose distributions by using the gamma index and dose volumetric indices for spine stereotactic body radiotherapy. Treatment plans were designed in accordance with the Radiation Therapy Oncology Group (RTOG) 0631 protocol. Measurements were taken using a Delta4 phantom (ScandiDos, Uppsala, Sweden). Setup errors were generated using the HexaMotion 6D moving platform (ScandiDos). Dose distributions in the presence of setup errors were evaluated, according to the γ passing rate with the 3% and 2 mm criteria (γ3%/2 mm) and dose volumetric indices (D90 for the target volume and D2 for the spinal cord), using the Delta4 device (ScandiDos)...
December 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29203290/patterns-of-locoregional-failure-in-locally-advanced-non-small-cell-lung-cancer-treated-with-definitive-conformal-radiotherapy-results-from-the-gating-2006-trial
#5
Emmanuel Jouglar, Vanina Isnardi, Dorothée Goulon, Céline Ségura-Ferlay, Myriam Ayadi, Claire Dupuy, Jean-Yves Douillard, Marc-André Mahé, Line Claude
PURPOSE: To determine the patterns of locoregional failure (LRF) in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy (RT). PATIENTS AND METHODS: One hundred and fifty-four patients from the Gating 2006 prospective randomized trial were treated with conformal RT with or without respiratory motion management. For patients with a LRF as first event, treatment planning with simulation CT, pre-treatment 18FDG PET-CT and post-treatment images demonstrating recurrence were registered and analyzed...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29199391/variations-in-the-practice-of-molecular-radiotherapy-and-implementation-of-dosimetry-results-from-a-european-survey
#6
Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg, Glenn Flux
BACKGROUND: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries. METHODS: An electronic questionnaire was distributed to European countries...
December 4, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/29195615/pet-ct-for-lymphoma-post-therapy-response-assessment-in-hodgkin-lymphoma-and-diffuse-large-b-cell-lymphoma
#7
REVIEW
Carsten Kobe, Markus Dietlein, Dirk Hellwig
Over the course of many decades, combined chemotherapy and radiotherapy adapted to the stage of disease have become the optimal and standard treatment for Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma. Besides achieving optimized cure rates of the underlying disease, reduction of toxicity has become a major goal. Since the introduction of FDG-PET for the staging and restaging of patients with lymphoma, a high predictive value of F-18-FDG-PET in response assessment has been observed. Several PET-response-guided therapy regimens have already been established, and even more PET-adapted study designs are being tested in large study groups...
January 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29193796/visibility-of-an-iron-containing-fiducial-marker-in-magnetic-resonance-imaging-for-high-precision-external-beam-prostate-radiotherapy
#8
Osamu Tanaka, Hisao Komeda, Shigeki Hirose, Takuya Taniguchi, Kousei Ono, Masayuki Matsuo
INTRODUCTION: Visualization of fiducial gold markers is critical for registration on computed tomography (CT) and magnetic resonance imaging (MRI) for imaging-guided radiotherapy. Although larger markers provide better visualization on MRI, they tend to generate artifacts on CT. MRI is strongly influenced by the presence of metals, such as iron, in the body. Here we compared efficacies of a 0.5% iron-containing gold marker (GM) and a traditional non-iron-containing marker. METHODS: Twenty-seven patients underwent CT/MRI fusion-based intensity-modulated radiotherapy...
November 29, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29188200/management-and-outcomes-of-gleason-six-prostate-cancer-detected-on-needle-biopsy-a-single-surgeon-experience-over-6%C3%A2-years
#9
Brayden March, George Koufogiannis, Mark Louie-Johnsun
Objective: To assess the management and oncological outcomes in men diagnosed with Gleason score (GS) 6 prostate cancer on needle biopsy in a regional centre, as compared with published international data. Materials and methods: A retrospective analysis was conducted of patients who were diagnosed with GS 6 prostate cancer via transrectal ultrasound-guided or transperineal biopsy between June 2009 and September 2015 under the care of a single surgeon. Data were obtained from a prospectively collected database...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29186565/computed-tomography-based-image-guided-brachytherapy-for-cervical-cancer-correlations-between-dose-volume-parameters-and-clinical-outcomes
#10
Takeaki Kusada, Takafumi Toita, Takuro Ariga, Hitoshi Maemoto, Seiji Hashimoto, Hideki Shiina, Yasumasa Kakinohana, Joichi Heianna, Yutaka Nagai, Wataru Kudaka, Yoichi Aoki, Sadayuki Murayama
This study evaluated the oncologic outcomes and complications of cervical cancer patients in terms of CT-based image-guided brachytherapy (IGBT) parameters. Of 68 cervical cancer patients treated with definitive radiotherapy/concurrent chemoradiotherapy, most received whole-pelvis external beam RT (EBRT) of 40 Gy in 20 fractions, pelvic EBRT with central shield of 10 Gy in 5 fractions, and CT-based IGBT of 18 Gy in 3 fractions prescribed to point A. Cumulative EBRT and IGBT doses were calculated as the total equivalent dose in 2 Gy fractions (EQD2)...
November 23, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29184684/impact-of-sarcopenia-on-outcomes-of-locally-advanced-esophageal-cancer-patients-treated-with-neoadjuvant-chemoradiation-followed-by-surgery
#11
Gilbert Z Murimwa, Puja S Venkat, William Jin, Susan Leuthold, Kujtim Latifi, Khaldoun Almhanna, Jose M Pimiento, Jacques-Pierre Fontaine, Sarah E Hoffe, Jessica M Frakes
Background: Sarcopenia is an independent predictor of clinical outcomes in multiple gastrointestinal cancers. Total psoas area (TPA), as measured on a single cross-sectional CT image at the L4 vertebral body level, has been correlated with sarcopenia. We sought to evaluate whether TPA was predictive of acute grade ≥3 toxicity, pathologic response, and overall survival in patients with locally advanced esophageal cancer receiving tri-modality therapy. Methods: An institutional database of esophageal cancer patients treated with neoadjuvant chemoradiation followed by surgery was queried...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29181556/oligometastases-in-prostate-cancer-metabolic-response-in-follow-up-psma-pet-cts-after-hypofractionated-igrt
#12
René Baumann, Mark Koncz, Ulf Luetzen, Fabian Krause, Juergen Dunst
BACKGROUND: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMAPET/CT) is a new and evolving diagnostic method in prostate cancer with special impact on treatment planning in image-guided radiotherapy (IGRT). Initial results of metabolic response in repeated PSMA PET/CTs after hypofractionated IGRT for metastatic lesions are reported here. MATERIALS AND METHODS: Of 280 patients investigated with 68Ga-PSMA PET/CT in the period from 01/2014 through 12/2016 in the authors' department, patients were selected according to the following criteria: oligometastatic disease at initial PSMA PET/CT defined as not more than five metastatic lesions, hypofractionated IGRT to all lesions, no systemic therapy in the last 6 months and during follow-up, and at least one follow-up PSMA PET after radiotherapy...
November 27, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29178983/hypofractionated-radiotherapy-for-prostate-cancer-in-the-postoperative-setting-what-is-the-evidence-so-far
#13
REVIEW
Cristina Picardi, Ioan Perret, Raymond Miralbell, Thomas Zilli
Postoperative external beam radiation therapy (EBRT) is a validated treatment option in the adjuvant setting for prostate cancer patients with aggressive pathological features following radical prostatectomy (RP) or as salvage modality in patients with biochemical recurrence after RP. Contemporary randomized phase III trials have provided evidence for using hypofractionation in the definitive treatment setting as an alternative to standard fractionated regimens. Biomathematical modeling for prostate cancer fractionated EBRT associated with widely available refined treatment delivery techniques such as volumetric modulated-arc therapy with image-guided RT may improve the therapeutic ratio...
November 14, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29178498/technical-note-solving-the-chinese-postman-problem-for-effective-contour-deformation
#14
Jingqian Wang, Yongbin Zhang, Lifei Zhang, Lei Dong, Peter A Balter, Laurence E Court, Jinzhong Yang
PURPOSE: To develop a practical approach for accurate contour deformation when deformable image registration (DIR) is used for atlas-based segmentation or contour propagation in image-guided radiotherapy. METHODS: We developed a contour deformation approach based on 3D mesh operations. The 2D contours represented by a series of points in each slice were first converted to a 3D triangular mesh, which was deformed by the deformation vectors resulting from DIR. A set of parallel 2D planes then cut through the deformed 3D mesh, generating unordered points and line segments, to be reorganized into a set of 2D contour points...
November 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/29178486/developing-and-characterizing-mr-ct-visible-materials-used-in-qa-phantoms-for-mrgrt-systems
#15
Angela Steinmann, R Jason Stafford, Gabriel Sawakuchi, Zhifei Wen, Laurence Court, Clifton D Fuller, David Followill
PURPOSE: Synthetic tissue equivalent (STE) materials currently used to simulate tumor and surrounding tissues for IROC-Houston's anthropomorphic head and thorax QA phantoms cannot be visualized using magnetic resonance (MR) imaging. The purpose of this study was to characterize dual MR/CT visible STE materials that can be used in an end-to-end QA phantom for MR guided radiotherapy (MRgRT) modalities. METHODS: Over 80 materials' MR, CT, and dosimetric STE properties were investigated for use in MRgRT QA phantoms...
November 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/29177134/automatic-detection-and-quantitative-dce-mri-scoring-of-prostate-cancer-aggressiveness
#16
Nestor Andres Parra, Alan Pollack, Felix M Chinea, Matthew C Abramowitz, Brian Marples, Felipe Munera, Rosa Castillo, Oleksandr N Kryvenko, Sanoj Punnen, Radka Stoyanova
Purpose: To develop a robust and clinically applicable automated method for analyzing Dynamic Contrast Enhanced (DCE-) MRI of the prostate as a guide for targeted biopsies and treatments. Materials and methods: An unsupervised pattern recognition (PR) method was used to analyze prostate DCE-MRI from 71 sequential radiotherapy patients. Identified regions of interest (ROIs) with increased perfusion were assigned either to the peripheral (PZ) or transition zone (TZ)...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29174940/absorbable-hydrogel-spacer-use-in-prostate-radiotherapy-a-comprehensive-review-of-phase-3-clinical-trial-published-data
#17
Lawrence Karsh, Eric Gross, Christopher M Pieczonka, Philip J Aliotta, Christopher J Skomra, Lee E Ponsky, Peter T Nieh, Misop Han, Daniel A Hamstra, Neal D Shore
OBJECTIVES: To provide an update on SpaceOAR® System, a FDA approved hydrogel indicated to create distance between the prostate and rectum which has been studied in phase 2 and 3 clinical trials. Here we review and summarize these clinical results including: the safety of prostate-rectum spacer application technique, the implant quality and resulting rectal dose reduction, acute and long term rectal, urinary and sexual toxicity as well as patient reported outcomes. METHODS: A prospective, randomized patient-blinded clinical study was performed comparing image-guided intensity modulated prostate radiotherapy (IG-IMRT) (79...
November 23, 2017: Urology
https://www.readbyqxmd.com/read/29174042/lipid-microbubbles-as-ultrasound-stimulated-oxygen-carriers-for-controllable-oxygen-release-for-tumor-reoxygenation
#18
Chunjiang Yang, Huan Xiao, Yang Sun, Lirong Zhu, Yang Gao, Sunny Kwok, Zhigang Wang, Yi Tang
Microbubbles are proposed as a potentially novel method for oxygen delivery in vivo in initial studies. The lack of commercial microbubbles for oxygen delivery in preclinical research prompted us to fabricate an oxygen-loaded lipid microbubble. We aimed to extend the innovative strategy to modulate the tumor hypoxic microenvironment, using microbubbles intravenously as an oxygen carrier for the controllable tumor-specific delivery of oxygen by ultrasound (US). In our experiment, an oxygen-loaded lipid-coated microbubble (OLM) with mixed gas (O2/C3 F8, 5:1 v/v) was fabricated and exhibited a higher rate of oxygen release to a desaturated solution through burst by US than that in the absence of US...
November 21, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29173912/generation-of-synthetic-ct-using-multi-scale-and-dual-contrast-patches-for-brain-mri-only-external-beam-radiotherapy
#19
Souha Aouadi, Ana Vasic, Satheesh Paloor, Tarraf Torfeh, Maeve McGarry, Primoz Petric, Mohamed Riyas, Rabih Hammoud, Noora Al-Hammadi
PURPOSE: To create a synthetic CT (sCT) from conventional brain MRI using a patch-based method for MRI-only radiotherapy planning and verification. METHODS: Conventional T1 and T2-weighted MRI and CT datasets from 13 patients who underwent brain radiotherapy were included in a retrospective study whereas 6 patients were tested prospectively. A new contribution to the Non-local Means Patch-Based Method (NMPBM) framework was done with the use of novel multi-scale and dual-contrast patches...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29173909/voxel-by-voxel-correlation-between-radiologically-radiation-induced-lung-injury-and-dose-after-image-guided-intensity-modulated-radiotherapy-for-lung-tumors
#20
Michele Avanzo, Sara Barbiero, Marco Trovo, Jean-Pierre Bissonnette, Rajesh Jena, Joseph Stancanello, Giovanni Pirrone, Fabio Matrone, Emilio Minatel, Cristina Cappelletto, Carlo Furlan, David A Jaffray, Giovanna Sartor
PURPOSE: To correlate radiation dose to the risk of severe radiologically-evident radiation-induced lung injury (RRLI) using voxel-by-voxel analysis of the follow-up computed tomography (CT) of patients treated for lung cancer with hypofractionated helical Tomotherapy. METHODS AND MATERIALS: The follow-up CT scans from 32 lung cancer patients treated with various regimens (5, 8, and 25 fractions) were registered to pre-treatment CT using deformable image registration (DIR)...
October 2017: Physica Medica: PM
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