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Image Guided Radiotherapy

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https://www.readbyqxmd.com/read/28205308/fast-and-robust-multimodal-image-registration-using-a-local-derivative-pattern
#1
Dongsheng Jiang, Yonghong Shi, Xinrong Chen, Manning Wang, Zhijian Song
PURPOSE: Deformable multimodal image registration, which can benefit radiotherapy and image guided surgery by providing complementary information, remains a challenging task in the medical image analysis field due to the difficulty of defining a proper similarity measure. This article presents a novel, robust and fast binary descriptor, the discriminative local derivative pattern (dLDP), which is able to encode images of different modalities into similar image representations. METHODS: dLDP calculates a binary string for each voxel according to the pattern of intensity derivatives in its neighborhood...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28170118/image-guided-interstitial-high-dose-rate-brachytherapy-in-the-treatment-of-inoperable-recurrent-head-and-neck-malignancies-an-effective-option-of-reirradiation
#2
Nikolaos Tselis, Efstratios Karagiannis, Christos Kolotas, Mehran Baghi, Natasa Milickovic, Nikolaos Zamboglou
BACKGROUND: In recurrent head and neck cancer, therapeutic options are limited and high-quality evidence is rare. The purpose of this report was to present our experience of CT-guided interstitial high-dose rate (HDR) brachytherapy in 4 challenging cases of inoperable recurrent head and neck cancer. METHODS: A 53-year-old man with mucosal melanoma of the paranasal sinuses, a 61-year-old man with myofibroblastic sarcoma of the nasal cavity, a 51-year-old woman with nasopharyngeal cancer, and a 44-year-old woman with orbital leiomyosarcoma were treated with reirradiation by HDR brachytherapy after previous comprehensive therapy, including full course external radiotherapy (RT)...
February 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28169225/intensity-based-2d-3d-registration-for-lead-localization-in-robot-guided-deep-brain-stimulation
#3
Stefan Hunsche, Dieter Sauner, Faycal El Majdoub, Clemens Neudorfer, Joerg Poggenborg, Axel Gossmann, Mohammad Maarouf
Intraoperative assessment of lead localization has become a standard procedure during deep brain stimulation (DBS) surgery in many centers, allowing immediate verification of targeting accuracy and, if necessary, adjustment of the trajectory. The most suitable imaging modality to determine lead positioning, however, remains controversially discussed. Current approaches entail the implementation of computed tomography and magnetic resonance imaging. In the present study, we adopted the technique of intensity-based 2D 3D registration that is commonly employed in stereotactic radiotherapy and spinal surgery...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28169196/patterns-of-care-of-cervical-cancer-in-the-elderly-a-qualitative-literature-review
#4
Venkatesulu Bhanu Prasad, Supriya Mallick, G K Rath
INTRODUCTION: Cancer of the uterine cervix is the fourth most common cancer worldwide among women. However, there is limited data about elderly cervical cancer patients and gross underrepresentation of elderly patients in clinical trials. Hence, the optimal therapy of such patients is not well formulated. METHODOLOGY: We conducted this systematic review of evidence to assess patterns of care in elderly patients with cervical cancer. RESULTS: A total of 17,338 publications are reported in PubMed until July, 2016 pertaining to cervical cancer...
February 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28154882/transperineal-gold-marker-implantation-for-image-guided-external-beam-radiotherapy-of-prostate-cancer-a-single-institution-prospective-study
#5
Kliton Jorgo, Péter Ágoston, Tibor Major, Zoltán Takácsi-Nagy, Csaba Polgár
PURPOSE: To present the feasibility and complications of transperineal fiducial marker implantation in prostate cancer patients undergoing image-guided radiotherapy (IGRT) METHODS AND MATERIALS: Between November 2011 and April 2016, three radiopaque, gold-plated markers were transperineally implanted into the prostate of 300 patients under transrectal ultrasound guidance and with local anaesthesia. A week after the procedure patients filled in a questionnaire regarding pain, dysuria, urinary frequency, nocturia, rectal bleeding, hematuria, hematospermia or fever symptoms caused by the implantation...
February 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28152619/a-multinational-report-of-technical-factors-on-stereotactic-body-radiotherapy-for-oligometastases
#6
Kristin J Redmond, Simon S Lo, Roi Dagan, Ian Poon, Matthew C Foote, Darby Erler, Young Lee, Frank Lohr, Tithi Biswas, Umberto Ricardi, Arjun Sahgal
AIM: Oligometastatic cancer is being increasingly managed with aggressive local therapy using stereotactic body radiation therapy (SBRT). However, few guidelines exist. We summarize the results of an international survey reviewing technical factors for extracranial SBRT for oligometastatic disease to guide safe management. MATERIALS & METHODS: Seven high-volume centers contributed. Levels of agreement were categorized as strong (6-7 common responses), moderate (4-5), low (2-3) or no agreement...
February 3, 2017: Future Oncology
https://www.readbyqxmd.com/read/28129973/acute-toxicity-and-its-dosimetric-correlates-for-high-risk-prostate-cancer-treated-with-moderately-hypofractionated-radiotherapy
#7
Moses Arunsingh, Indranil Mallick, Sriram Prasath, B Arun, Sandip Sarkar, Raj Kumar Shrimali, Sanjoy Chatterjee, Rimpa Achari
AIMS: To report the acute toxicity and the dosimetric correlates after moderately hypofractionated radiotherapy for localized prostate cancer. METHODS: A total of 101 patients with localized prostate cancer were treated with image-guided intensity-modulated radiation therapy. Patients were treated to 65Gy/25Fr/5 weeks (n = 18), or 60Gy/20Fr/4 weeks (n = 83). Most (82.2%) had high-risk or pelvic node-positive disease. Acute toxicity was assessed using Radiation Therapy Oncology Group (RTOG) acute morbidity scoring criteria...
January 24, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28115962/image-guided-high-dose-rate-brachytherapy-of-head-and-neck-a-case-series-study
#8
Paweł Cisek, Dariusz Kieszko, Anna Brzozowska, Izabela Kordzin'ska-Cisek, Maria Mazurkiewicz
PURPOSE: The aim of the study was the evaluation of image guided transdermal application of interstitial brachytherapy in patients undergoing repeated irradiation for relapsed local tumor of the head and neck area. MATERIAL AND METHODS: The article describes transdermal application of interstitial high-dose-rate (HDR) brachytherapy in 4 patients treated due to relapsed local tumor in soft palate, submandibular area, laryngopharynx, as well as pterygoid muscles and maxillary sinus...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28113548/visualization-of-deformable-image-registration-quality-using-local-image-dissimilarity
#9
Matthias Schlachter, Tobias Fechter, Miro Jurisic, Tanja Schimek-Jasch, Oliver Oehlke, Sonja Adebahr, Wolfgang Birkfellner, Ursula Nestle, Katja Buhler
Deformable image registration (DIR) has the potential to improve modern radiotherapy in many aspects, including volume definition, treatment planning and image-guided adaptive radiotherapy. Studies have shown its possible clinical benefits. However, measuring DIR accuracy is difficult without known ground truth, but necessary before integration in the radiotherapy workflow. Visual assessment is an important step towards clinical acceptance. We propose a visualization framework which supports the exploration and the assessment of DIR accuracy...
April 29, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28113225/system-integration-and-in-vivo-testing-of-a-robot-for-ultrasound-guidance-and-monitoring-during-radiotherapy
#10
Hasan Sen, Muyinatu Lediju Bell, Yin Zhang, Kai Ding, Emad Boctor, John Wong, Iulian Iordachita, Peter Kazanzides
We are developing a cooperatively-controlled robot system for image-guided radiation therapy (IGRT) in which a clinician and robot share control of a 3D ultrasound (US) probe. IGRT involves two main steps: (1) planning/ simulation and (2) treatment delivery. The goals of the system are to provide guidance for patient setup and realtime target monitoring during fractionated radiotherapy of soft tissue targets, especially in the upper abdomen. To compensate for soft tissue deformations created by the probe, we present a novel workflow where the robot holds the US probe on the patient during acquisition of the planning computerized tomography (CT) image, thereby ensuring that planning is performed on the deformed tissue...
October 3, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28102960/nine-degrees-of-freedom-flexmap-for-a-cone-beam-computed-tomography-imaging-device-with-independently-movable-source-and-detector
#11
Peter Keuschnigg, Daniel Kellner, Karl Fritscher, Andrea Zechner, Ulrich Mayer, Philipp Huber, Felix Sedlmayer, Heinz Deutschmann, Philipp Steininger
PURPOSE: Couch-mounted cone-beam computed tomography (CBCT) imaging devices with independently rotatable x-ray source and flat-panel detector arms for acquisitions of arbitrary regions of interest (ROI) have recently been introduced in image-guided radiotherapy (IGRT). This work analyzes mechanical limitations and gravity-induced effects influencing the geometric accuracy of images acquired with arbitrary angular constellations of source and detector in nonisocentric trajectories, which is considered essential for IGRT...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28074785/deformable-registration-of-ct-and-cone-beam-ct-with-local-intensity-matching
#12
Seyoun Park, William Plishker, Harry Quon, John Wong, Raj Shekhar, Junghoon Lee
Cone-beam CT (CBCT) is a widely used intra-operative imaging modality in image-guided radiotherapy and surgery. A short scan followed by a filtered-backprojection is typically used for CBCT reconstruction. While data on the mid-plane (plane of source-detector rotation) is complete, off-mid-planes undergo different information deficiency and the computed reconstructions are approximate. This causes different reconstruction artifacts at off-mid-planes depending on slice locations, and therefore impedes accurate registration between CT and CBCT...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28069053/influence-of-daily-imaging-on-plan-quality-and-normal-tissue-toxicity-for-prostate-cancer-radiotherapy
#13
Katharina Bell, Marina Heitfeld, Norbert Licht, Christian Rübe, Yvonne Dzierma
BACKGROUND: Modern radiotherapy offers various possibilities for image guided verification of patient positioning. Different clinically relevant IGRT (image guided radiotherapy) scenarios were considered with regard to their influence on dosimetric plan quality and normal tissue complication probability (NTCP). METHODS: This study is based on treatment plans of 50 prostate patients. We evaluate the clinically performed IGRT and simulate the influence of different daily IGRT scenarios on plan quality...
January 10, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28060412/optimizing-dual-energy-x-ray-parameters-for-the-exactrac-clinical-stereoscopic-imaging-system-to-enhance-soft-tissue-imaging
#14
Wesley A Bowman, James L Robar, Mike Sattarivand
PURPOSE: Stereoscopic x-ray image guided radiotherapy for lung tumors is often hindered by bone overlap and limited soft tissue contrast. This study aims to evaluate the feasibility of dual-energy imaging techniques and to optimize parameters of the ExacTrac stereoscopic imaging system to enhance soft tissue imaging for application to lung stereotactic body radiation therapy. METHODS: Simulated spectra and a physical lung phantom were used to optimize filter material, thickness, tube potentials, and weighting factors to obtain bone subtracted dual-energy images...
January 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28048919/su-g-jep3-05-geometry-based-transperineal-ultrasound-probe-positioning-for-image-guided-radiotherapy
#15
S Camps, F Verhaegen, P de With, D Fontanarosa
PURPOSE: The use of ultrasound (US) imaging in radiotherapy is not widespread, primarily due to the need for skilled operators performing the scans. Automation of probe positioning has the potential to remove this need and minimize operator dependence. We introduce an algorithm for obtaining a US probe position that allows good anatomical structure visualization based on clinical requirements. The first application is on 4D transperineal US images of prostate cancer patients. METHODS: The algorithm calculates the probe position and orientation using anatomical information provided by a reference CT scan, always available in radiotherapy workflows...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048884/th-ef-204-02-small-field-radiation-therapy-physics-and-recent-recommendations-from-iaea-and-icru
#16
J Seuntjens
: Joanna E. Cygler, Jan Seuntjens, J. Daniel Bourland, M. Saiful Huq, Josep Puxeu Vaque, Daniel Zucca Aparicio, Tatiana Krylova, Yuri Kirpichev, Eric Ford, Caridad Borras Stereotactic Radiation Therapy (SRT) utilizes small static and dynamic (IMRT) fields, to successfully treat malignant and benign diseases using techniques such as Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation Therapy (SBRT). SRT is characterized by sharp dose gradients for individual fields and their resultant dose distributions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048869/su-f-j-145-mri-guided-interventional-boost-radiotherapy-for-rectal-cancer-investigating-the-feasibility-of-adapting-the-anatomy
#17
J J E Kleijnen, A M Couwenberg, B van Asselen, J J W Lagendijk, M Intven, B W Raaymakers
PURPOSE: The recent development of an MRI-linac allows adaptation of treatments to the anatomy of the moment. This anatomy, in turn, could be altered into a more favorable situation for radiotherapy purposes. The purpose of this study is to investigate the potential dosimetric benefits of manipulating rectal anatomy in MRI-guided interventional external-beam radiotherapy for rectal cancer. METHODS: For this retrospective analysis, four patients (1M/3F) diagnosed with rectal cancer were included...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048862/th-e-202-02-the-use-of-hypoxia-pet-imaging-for-radiotherapy
#18
J Humm
: PET/CT is a very important imaging tool in the management of oncology patients. PET/CT has been applied for treatment planning and response evaluation in radiation therapy. This educational session will discuss: 1. Pitfalls and remedies in PET/CT imaging for RT planning 2. The use of hypoxia PET imaging for radiotherapy 3. PET for tumor response evaluation The first presentation will address the issue of mis-registration between the CT and PET images in the thorax and the abdomen. We will discuss the challenges of respiratory gating and introduce an average CT technique to improve the registration for dose calculation and image-guidance in radiation therapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048833/su-g-iep1-13-sub-nyquist-dynamic-mri-via-prior-rank-intensity-and-sparsity-model-prism
#19
B Jiang, H Gao
PURPOSE: Accelerated dynamic MRI is important for MRI guided radiotherapy. Inspired by compressive sensing (CS), sub-Nyquist dynamic MRI has been an active research area, i.e., sparse sampling in k-t space for accelerated dynamic MRI. This work is to investigate sub-Nyquist dynamic MRI via a previously developed CS model, namely Prior Rank, Intensity and Sparsity Model (PRISM). METHODS: The proposed method utilizes PRISM with rank minimization and incoherent sampling patterns for sub-Nyquist reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048815/su-f-j-59-assessment-of-dose-response-distribution-in-individual-human-tumor
#20
D Yan, S Chen, D Krauss, P Chen, G Wilson
PURPOSE: To fulfill precision radiotherapy via adaptive dose painting by number, voxel-by-voxel dose response or radio-sensitivity in individual human tumor needs to be determined in early treatment to guide treatment adaptation. In this study, multiple FDG PET images obtained pre- and weekly during the treatment course were utilized to determine the distribution/spectrum of dose response parameters in individual human tumors. METHODS: FDG PET/CT images of 18 HN cancer patients were used in the study...
June 2016: Medical Physics
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