keyword
MENU ▼
Read by QxMD icon Read
search

Image Guided Radiotherapy

keyword
https://www.readbyqxmd.com/read/29045981/renal-ewing-s-sarcoma-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#1
C Liu, L G Cui, H L Wang
Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) in the kidney is a rare but high-grade malignant tumor that affects predominantly elder children and adolescents. Patients mostly present with nonspecific symptoms such as abdominal pain and gross hematuria. Since EWS/PNET has a rapid clinical progression with early metastasis and death, it is essential to make an accurate and early diagnosis. Once diagnosed, multimodality treatment, including radical surgery combined with adjuvant chemotherapy, and radiotherapy if necessary, is recommended...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29044630/fully-automatic-deformable-registration-of-pre-treatment-mri-ct-for-image-guided-prostate-radiotherapy-planning
#2
Iyas Hamdan, Julien Bert, Catherine Cheze Le Rest, Jean Pierre Tasu, Nicolas Boussion, Antoine Valeri, Guillaume Dardenne, Dimitris Visvikis
PURPOSE: In prostate radiotherapy, dose distribution may be calculated on CT images, while the MRI can be used to enhance soft tissue visualization. Therefore, a registration between MR and CT images could improve the overall treatment planning process, by improving visualization with a demonstrated inter-observer delineation variability when segmenting the prostate, which in turn can lead to a more precise planning. This registration must compensate for prostate deformations caused by changes in size and form between the acquisitions of both modalities...
October 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29037025/gross-tumor-volume-dependency-on-phase-sorting-methods-of-four-dimensional-computed-tomography-images-for-lung-cancer
#3
Soo Yong Lee, Sangwook Lim, Sun Young Ma, Jesang Yu
PURPOSE: To see the gross tumor volume (GTV) dependency according to the phase selection and reconstruction methods, we measured and analyzed the changes of tumor volume and motion at each phase in 20 cases with lung cancer patients who underwent image-guided radiotherapy. MATERIALS AND METHODS: We retrospectively analyzed four-dimensional computed tomography (4D-CT) images in 20 cases of 19 patients who underwent image-guided radiotherapy. The 4D-CT images were reconstructed by the maximum intensity projection (MIP) and the minimum intensity projection (Min-IP) method after sorting phase as 40%-60%, 30%-70%, and 0%-90%...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035992/18f-faza-pet-ct-hypoxia-imaging-of-high-grade-glioma-before-and-after-radiotherapy
#4
Paola Mapelli, Flavia Zerbetto, Elena Incerti, Gian Marco Conte, Valentino Bettinardi, Federico Fallanca, Nicoletta Anzalone, Nadia Di Muzio, Luigi Gianolli, Maria Picchio
A 57 year-old man underwent MRI with dynamic susceptibility contrast and dynamic contrast-enhanced perfusion for neurological symptoms suggesting the diagnosis of high-grade glioma. A F-FAZA PET/CT was performed because of the enrollment in a prospective clinical trial. Subsequent radiotherapy treatment has been planned based on conventional imaging; moreover, a F-FAZA PET/CT-guided treatment planning highlighting hypoxic regions has been simulated. After radiotherapy treatment, the man underwent MRI and F-FAZA PET/CT, showing partial response...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29031916/image-guided-adaptive-external-beam-radiation-therapy-for-cervix-cancer-evaluation-of-a-clinically-implemented-plan-of-the-day-technique
#5
Martin Buschmann, Katarina Majercakova, Alina Sturdza, Stephanie Smet, Dina Najjari, Michaela Daniel, Richard Pötter, Dietmar Georg, Yvette Seppenwoolde
BACKGROUND: Radiotherapy for cervix cancer is challenging in patients exhibiting large daily changes in the pelvic anatomy, therefore adaptive treatments (ART) have been proposed. The aim of this study was the clinical implementation and subsequent evaluation of plan-of-the-day (POTD)-ART for cervix cancer in supine positioning. The described workflow was based on standard commercial equipment and current quality assurance (QA) methods. MATERIALS AND METHODS: A POTD strategy, which employs a VMAT plan library consisting of an empty bladder plan, a full bladder plan and a motion robust backup plan, was developed...
October 11, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29030460/hmg-coa-reductase-inhibition-delays-dna-repair-and-promotes-senescence-after-tumor-irradiation
#6
Elena V Efimova, Natalia Ricco, Edwardine Labay, Helena J Mauceri, Amy C Flor, Aishwarya Ramamurthy, Harold G Sutton, Ralph R Weichselbaum, Stephen J Kron
Despite significant advances in combinations of radiotherapy and chemotherapy, altered fractionation schedules and image-guided radiotherapy, many cancer patients fail to benefit from radiation. A prevailing hypothesis is that targeting repair of DNA double strand breaks (DSBs) can enhance radiation effects in the tumor and overcome therapeutic resistance without incurring off-target toxicities. Unrepaired DSBs can block cancer cell proliferation, promote cancer cell death and induce cellular senescence. Given the slow progress to date translating novel DSB repair inhibitors as radiosensitizers, we have explored drug repurposing, a proven route to improving speed, costs and success rates of drug development...
October 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#7
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#8
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28993798/challenges-for-quality-assurance-of-target-volume-delineation-in-clinical-trials
#9
REVIEW
Amy Tien Yee Chang, Li Tee Tan, Simon Duke, Wai-Tong Ng
In recent years, new radiotherapy techniques have emerged that aim to improve treatment outcome and reduce toxicity. The standard method of evaluating such techniques is to conduct large scale multicenter clinical trials, often across continents. A major challenge for such trials is quality assurance to ensure consistency of treatment across all participating centers. Analyses from previous studies have shown that poor compliance and protocol violation have a significant adverse effect on treatment outcomes...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28992409/hypoxia-targeting-tumor-microenvironment-responsive-nanocluster-bomb-for-radical-enhanced-radiotherapy
#10
Da Huo, Sen Liu, Chao Zhang, Jian He, Zhengyang Zhou, Hao Zhang, Yong Hu
Although ultrasmall metal nanoparticles (NPs) have been used as radiosensitizers to enhance the local damage to tumor tissues while reducing injury to the surrounding organs, their rapid clearance from the circulatory system and the presence of hypoxia within the tumor continue to hamper their further application in radiotherapy (RT). In this study, we report a size tunable nanocluster bomb with a initial size of approximately 33 nm featuring a long half-life during blood circulation and destructed to release small hypoxia microenvironment-targeting NPs (∼5 nm) to achieve deep tumor penetration...
October 11, 2017: ACS Nano
https://www.readbyqxmd.com/read/28992047/preliminary-comparison-of-the-registration-effect-of-4d-cbct-and-3d-cbct-in-image-guided-radiotherapy-of-stage-ia-non-small-cell-lung-cancer
#11
Zhibo Tan, Chuanyao Liu, Ying Zhou, Weixi Shen
In this study, we compared the registration effectiveness of 4D cone-beam computed tomography (CBCT) and 3D-CBCT for image-guided radiotherapy in 20 Stage IA non-small-cell lung cancer (NSCLC) patients. Patients underwent 4D-CBCT and 3D-CBCT immediately before radiotherapy, and the X-ray Volume Imaging software system was used for image registration. We performed automatic bone registration and soft tissue registration between 4D-CBCT or 3D-CBCT and 4D-CT images; the regions of interest (ROIs) were the vertebral body on the layer corresponding to the tumor and the internal target volume region...
July 15, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28982908/long-term-tumor-control-and-late-toxicity-in-patients-with-prostate-cancer-receiving-hypofractionated-2-2-gy-soft-tissue-matched-image-guided-intensity-modulated-radiotherapy
#12
Daisuke Shimizu, Hideya Yamazaki, Takuya Nishimura, Norihiro Aibe, Haruumi Okabe
AIM: We report the long-term tumor control and toxicity outcomes of patients undergoing hypofractionated (2.2 Gy) image-guided intensity-modulated radiotherapy (IG-IMRT) using tomotherapy for clinically localized prostate cancer. PATIENTS AND METHODS: We examined the cases of 138 consecutive patients with stage T1-T3 prostate cancer that were treated with IG-IMRT from June 2007 to July 2009. The median follow-up time was 79 months (range=31-96 months). The planning target volume received a dose of 72...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982035/a-finite-element-based-machine-learning-approach-for-modeling-the-mechanical-behavior-of-the-breast-tissues-under-compression-in-real-time
#13
F Martínez-Martínez, M J Rupérez-Moreno, M Martínez-Sober, J A Solves-Llorens, D Lorente, A J Serrano-López, S Martínez-Sanchis, C Monserrat, J D Martín-Guerrero
This work presents a data-driven method to simulate, in real-time, the biomechanical behavior of the breast tissues in some image-guided interventions such as biopsies or radiotherapy dose delivery as well as to speed up multimodal registration algorithms. Ten real breasts were used for this work. Their deformation due to the displacement of two compression plates was simulated off-line using the finite element (FE) method. Three machine learning models were trained with the data from those simulations. Then, they were used to predict in real-time the deformation of the breast tissues during the compression...
September 28, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28976313/assessment-of-rigid-registration-quality-measures-in-ultrasound-guided-radiotherapy
#14
Roozbeh Shams, Yiming Xiao, Francois Hebert, Matthew Abramowitz, Rupert Brooks, Hassan Rivaz
Image guidance has become the standard of care for patient positioning in radiotherapy, where image registration is often a critical step to help manage patient motion. However, in practice, verification of registration quality is often adversely affected by difficulty in manual inspection of 3D images and time constraint, thus affecting the therapeutic outcome. Therefore, we proposed to employ both bootstrapping and the supervised learning methods of linear discriminant analysis and random forest to help robustly assess registration quality in ultrasound-guided radiotherapy...
September 28, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28965894/intrafraction-monitoring-of-prostate-motion-during-radiotherapy-using-the-clarity-%C3%A2-autoscan-transperineal-ultrasound-tpus-system
#15
A K Richardson, P Jacobs
INTRODUCTION: Implementation of the Clarity(®) Autoscan (Elekta) Transperineal Ultrasound (TPUS) system in Bristol is the first of its kind in the UK and we have already shown its utility in interfractional Image Guided Radiotherapy (IGRT).(14) This study establishes the extent of intrafraction prostate motion as measured by Clarity and explores the potential benefits of TPUS for intrafraction monitoring. METHODS: Monitoring data was analysed for 526 fractions from 20 localised prostate cancer patients...
November 2017: Radiography
https://www.readbyqxmd.com/read/28963789/-18-f-fluoromisonidazole-positron-emission-tomography-ct-guided-volumetric-modulated-arc-therapy-based-dose-escalation-for-hypoxic-subvolume-in-nasopharyngeal-carcinomas-a-feasibility-study
#16
Jianjian Qiu, Bo Lv, Meina Fu, Xianglian Wang, Xiangpeng Zheng, Weihai Zhuo
BACKGROUND: The purpose of this study is to investigate the feasibility of a simultaneously integrated boost to the hypoxic subvolume of nasopharyngeal carcinomas (NCPs) under the guidance of (18) F-fluoromisonidazole (FMISO) positron emission tomography (PET)/CT using volumetric-modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) techniques. METHODS: Eight patients with NPC were treated with simultaneous integrated boost-IMRT (treatment plan named IMRT70) with dose prescriptions of 70 Gy, 66 Gy, 60 Gy, and 54 Gy to the gross tumor volume (GTV), positive neck nodes, the planning target volume (PTV), and the clinically negative neck, respectively...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28958472/evaluation-of-dose-recalculation-vs-dose-deformation-in-a-commercial-platform-for-deformable-image-registration-with-a-computational-phantom
#17
Marco Fusella, Francesca R Giglioli, Christian Fiandra, Riccardo Ragona
Deformable image registration (DIR) is an important tool for mapping both dose and contours of a new set of planning images when recurrent, that is, adaptive radiotherapy, or further treatment, that is, re-treatment, is required. The aim of this study was to evaluate the need for plan recalculation in deformed anatomies and to develop a reliable workflow for validating the DIR algorithm to be applied to dose warping such as dose accumulation (DA) for adaptive radiation therapy, and dose summation (DS) in the case of re-treatment...
September 25, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28952463/a-monte-carlo-study-of-organ-and-effective-doses-of-cone-beam-computed-tomography-cbct-scans-in-radiotherapy
#18
Abdullah Abuhaimed, Colin J Martin, Marimuthu Sankaralingam
Cone-beam CT (CBCT) scans utilized for image guided radiation therapy (IGRT) procedures have become an essential part of radiotherapy. The aim of this study was to assess organ and effective doses resulting from new CBCT scan protocols (head, thorax, and pelvis) released with a software upgrade of the kV on-board-imager (OBI) system. Influence of the scan parameters that were changed in the new protocols on the patient dose was also investigated. Organ and effective doses for protocols of the new software (V2...
September 27, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28951756/inflatable-multichannel-rectal-applicator-for-adaptive-image-guided-endoluminal-high-dose-rate-rectal-brachytherapy-design-dosimetric-characteristics-and-first-clinical-experiences
#19
Maximilian P Schmid, Daniel Berger, Martin Heilmann, Jessica Bör, Bernd Wisgrill, Ursula Azizi-Semrad, Nicole Nesvacil, Richard Pötter, Christian Kirisits, Rainer Schmid
PURPOSE: To investigate the dosimetric results and first clinical experiences with a new designed balloon applicator with adjustable catheters for endoluminal brachytherapy for patients with locally advanced rectal cancer not undergoing surgery. MATERIAL AND METHODS: The applicator consists of an inflatable rectal balloon with six attached Foley catheters used as guidance for the inserted brachytherapy plastic needles. The construction of the applicator and the dosimetric profile in terms of representative dose points in 0, 2, 5, 10 mm ipsilaterally and in 0 mm contralaterally are described...
August 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28930092/a-monte-carlo-study-to-assess-the-effect-of-1-5t-magnetic-fields-on-the-overall-robustness-of-pencil-beam-scanning-proton-radiotherapy-plans-for-prostate-cancer
#20
Christopher Kurz, Guillaume Landry, Andreas Franz Resch, Georgios Dedes, Florian Kamp, Ute Ganswindt, Claus Belka, Bas W Raaymakers, Katia Parodi
Combining magnetic-resonance imaging (MRI) and proton therapy (PT) using pencil-beam scanning (PBS) may improve image-guided radiotherapy. We aimed at assessing the impact of a magnetic field on PBS-PT plan quality and robustness. Specifically, the robustness against anatomical changes and positioning errors in an MRI-guided scenario with a 30 cm radius 1.5 T magnetic field was studied for prostate PT. Five prostate cancer patients with three consecutive CT images (CT1-3) were considered. Single-field uniform dose PBS-PT plans were generated on the segmented CT1 with Monte-Carlo-based treatment planning software for inverse optimization...
September 20, 2017: Physics in Medicine and Biology
keyword
keyword
55732
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"