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Image Guided Radiotherapy

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https://www.readbyqxmd.com/read/27925472/image-guided-radiotherapy-for-prostate-cancer-in-the-united-kingdom-a-national-survey
#1
Hemal Ariyaratne, Hayley Chesham, Roberto Alonzi
OBJECTIVES: To survey the technology and practice of image-guided radiotherapy for prostate cancer in the United Kingdom Methods: A pre-tested semi-structured online questionnaire was sent to NHS and private radiotherapy providers in the United Kingdom between March and April 2014. The survey was carried out on the Opinio© online platform. RESULTS: There was a high survey response rate of 83%. There is widespread use of intensity-modulated radiotherapy and advanced verification imaging modalities...
December 7, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27920610/volumetric-image-guided-highly-conformal-radiotherapy-of-the-prostate-bed-toxicity-analysis
#2
Gianluca Ingrosso, Alessandra Carosi, Daniela di Cristino, Elisabetta Ponti, Andrea Lancia, Alessandra Murgia, Claudia Bruni, Pasquale Morelli, Franca Pietrasanta, Riccardo Santoni
AIM: To evaluate toxicity of high conformal image-guided radiotherapy of the prostate bed. BACKGROUND: Radiotherapy of the prostate bed has a pivotal role in the post-operative and salvage settings, but few clinical data are available on the use of daily image guidance in combination with highly conformal techniques, and data on long-term results are lacking. MATERIALS AND METHODS: We analyzed 118 patients irradiated on the prostate bed using conformal plans processed with a micro-multileaf collimator, and daily checking treatment set-up with a cone-beam CT system...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27917527/simultaneous-orthogonal-plane-imaging
#3
Nikolai J Mickevicius, Eric S Paulson
PURPOSE: Intrafraction motion can result in a smearing of planned external beam radiation therapy dose distributions, resulting in an uncertainty in dose actually deposited in tissue. The purpose of this paper is to present a pulse sequence that is capable of imaging a moving target at a high frame rate in two orthogonal planes simultaneously for MR-guided radiotherapy. THEORY: By balancing the zero gradient moment on all axes, slices in two orthogonal planes may be spatially encoded simultaneously...
December 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27913106/innovations-in-radiotherapy-technology
#4
I J Feain, L Court, J R Palta, S Beddar, P Keall
Many low- and middle-income countries, together with remote and low socioeconomic populations within high-income countries, lack the resources and services to deal with cancer. The challenges in upgrading or introducing the necessary services are enormous, from screening and diagnosis to radiotherapy planning/treatment and quality assurance. There are severe shortages not only in equipment, but also in the capacity to train, recruit and retain staff as well as in their ongoing professional development via effective international peer-review and collaboration...
November 29, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27910826/enhancing-radiotherapy-for-lung-cancer-using-immunoadjuvants-delivered-in-situ-from-new-design-radiotherapy-biomaterials-a-preclinical-study
#5
Yao Hao, Sayeda Yasmin-Karim, Michele Moreau, Neeharika Sinha, Erno Sajo, Wilfred Ngwa
Studies show that radiotherapy of a primary tumor in combination with immunoadjuvants (IA) can result in increased survival or immune-mediated regression of metastasis outside the radiation field, a phenomenon known as abscopal effect. However, toxicities due to repeated systematic administration of IA have been shown to be a major obstacle in clinical trials. To minimize the toxicities and prime a more potent immune response, Ngwa et al have proposed that inert radiotherapy biomaterials such as fiducials could be upgraded to multifunctional ones loaded with IA for in situ delivery directly into the tumor sub-volume at no additional inconvenience to patients...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27908165/a-comparison-of-two-prospective-risk-analysis-methods-traditional-fmea-and-a-modified-healthcare-fmea
#6
Jeong-Eun Rah, Ryan P Manger, Adam D Yock, Gwe-Ya Kim
PURPOSE: To examine the abilities of a traditional failure mode and effects analysis (FMEA) and modified healthcare FMEA (m-HFMEA) scoring methods by comparing the degree of congruence in identifying high risk failures. METHODS: The authors applied two prospective methods of the quality management to surface image guided, linac-based radiosurgery (SIG-RS). For the traditional FMEA, decisions on how to improve an operation were based on the risk priority number (RPN)...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908161/technical-note-magnetic-field-effects-on-gafchromic-film-response-in-mr-igrt
#7
Francisco J Reynoso, Austen Curcuru, Olga Green, Sasa Mutic, Indra J Das, Lakshmi Santanam
PURPOSE: Magnetokinetic changes may affect crystal orientation and polymerization within the active layer of radiochromic film (RCF). This effect is investigated in a magnetic resonance image-guided radiotherapy unit within the context of film dosimetry. METHODS: Gafchromic EBT2 RCF was irradiated in a 30 × 30 × 30 cm(3) solid water phantom using a Co-60 MRI guided radiotherapy system (B = 0.35 T) under normal operating conditions, and under the exact conditions and setup without a magnetic field...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27903114/a-quantitative-analysis-of-craniopharyngioma-cyst-expansion-during-and-after-radiation-therapy-and-surgical-implications
#8
Kelly Lamiman, Kenneth K Wong, Benita Tamrazi, Jason D Nosrati, Arthur Olch, Eric L Chang, Erin N Kiehna
OBJECTIVE When complete resection of craniopharyngioma is not achievable or the sequelae are prohibitive, limited surgery and radiation therapy have demonstrated excellent local disease control while minimizing treatment-related sequelae. When residual tissue exists, there is a propensity for further cyst development and expansion during and after radiation therapy. This can result in obstructive hydrocephalus, visual changes, and/or clinical decline. The authors present a quantitative analysis of cyst expansion during and after radiotherapy and examine how it affected subsequent management...
December 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27895686/successful-treatment-of-a-67-year-old-woman-with-urethral-adenocarcinoma-with-the-use-of-external-beam-radiotherapy-and-image-guided-adaptive-interstitial-brachytherapy
#9
Jasmin Mujkanovic, Kari Tanderup, Mads Agerbæk, Ulla Bisgaard, Søren Høyer, Jacob Christian Lindegaard, Lars Fokdal
Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27891213/uk-guidelines-for-the-management-of-soft-tissue-sarcomas
#10
REVIEW
Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan, Ian Judson
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27872946/implementation-of-image-guided-intensity-modulated-accelerated-partial-breast-irradiation-three-year-results-of-a%C3%A2-phase%C3%A2-ii-clinical-study
#11
Norbert Mészáros, Tibor Major, Gábor Stelczer, Zoltán Zaka, Emőke Mózsa, Dávid Pukancsik, Zoltán Takácsi-Nagy, János Fodor, Csaba Polgár
PURPOSE: To report 3‑year results of accelerated partial breast irradiation (APBI) using image-guided intensity-modulated radiotherapy (IG-IMRT) following breast conserving surgery (BCS) for low-risk early invasive breast cancer. PATIENTS AND METHODS: Between July 2011 and March 2014, 60 patients with low-risk early invasive breast cancer underwent BCS and were enrolled in this phase II prospective study. The total dose was 36.9 Gy (9 fractions of 4.1 Gy, two fractions/day)...
November 21, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27868105/feasibility-of-automated-3-dimensional-magnetic-resonance-imaging-pancreas-segmentation
#12
Shuiping Gou, Percy Lee, Peng Hu, Jean-Claude Rwigema, Ke Sheng
PURPOSE: With the advent of MR guided radiotherapy, internal organ motion can be imaged simultaneously during treatment. In this study, we evaluate the feasibility of pancreas MRI segmentation using state-of-the-art segmentation methods. METHODS AND MATERIAL: T2 weighted HASTE and T1 weighted VIBE images were acquired on 3 patients and 2 healthy volunteers for a total of 12 imaging volumes. A novel dictionary learning (DL) method was used to segment the pancreas and compared to t mean-shift merging (MSM), distance regularized level set (DRLS), graph cuts (GC) and the segmentation results were compared to manual contours using Dice's index (DI), Hausdorff distance and shift of the-center-of-the-organ (SHIFT)...
July 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/27863019/78gy-with-fiducial-marker-image-guided-radiotherapy-in-prostate-cancer-single-center-analysis-of-301-patients
#13
Ee Siang Choong, George Hruby, Jean Yang, Carol Kwong, Nitya Patanjali
AIM: In prostate cancer, fiducial marker image-guided radiotherapy (FMIGRT) allows correction of setup errors and interfraction physiological motion resulting in improved accuracy of target and sparing of at risk organs. We aim to report outcomes and toxicities observed in patients treated with dose escalation to 78Gy with FMIGRT in our center. METHODS AND MATERIALS: Retrospective review of consecutive patients with histologically confirmed T1-4N0M0 localized prostate cancer treated with dose escalation to 78Gy with FMIGRT in our center...
November 10, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27863010/survey-of-image-guided-radiotherapy-use-in-australia
#14
Vikneswary Batumalai, Lois Charlotte Holloway, Shivani Kumar, Kylie Dundas, Michael Geoffrey Jameson, Shalini Kavita Vinod, Geoff P Delaney
INTRODUCTION: This study aimed to evaluate the current use of imaging technologies for planning and delivery of radiotherapy (RT) in Australia. METHODS: An online survey was emailed to all Australian RT centres in August 2015. The survey inquired about imaging practices during planning and treatment delivery processes. Participants were asked about the types of image-guided RT (IGRT) technologies and the disease sites they were used for, reasons for implementation, frequency of imaging and future plans for IGRT use in their department...
November 9, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27860454/geographical-miss-of-the-prostate-during-image-guided-radiotherapy-with-a-6-mm-posterior-expansion-margin
#15
Richard Oates, Daryl Jones, Farshad Foroudi, Suki Gill, Prabhakar Ramachandran, Michal Schneider, Michael LimJoon, Tomas Kron
INTRODUCTION: Our department commonly uses a planning target volume (PTV) expansion of 6 mm posterior and 1 cm in all other directions when treating prostate cancer patients with image-guided radiotherapy (IGRT). This study aimed to test the adequacy of this PTV expansion by assessing geographical miss of the prostate on post-treatment cone-beam CT (CBCT) and identify those at risk of geographical miss. METHODS: Twenty-two prostate cancer patients receiving IGRT with implanted fiducial markers underwent daily pre-treatment orthogonal kV imaging followed by a post-treatment CBCT for a total of 432 fractions...
November 8, 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27860163/11c-acetate-pet-ct-imaging-for-detection-of-recurrent-disease-following-radical-prostatectomy-or-radiotherapy-in-patients-with-prostate-cancer
#16
L Esch, M Fahlbusch, P Albers, H Hautzel, V Müller-Mattheis
OBJECTIVES: To evaluate the effectiveness of CT-matched 11C-acetate PET (AC-PET) in prostate cancer patients with PSA relapse following radical prostatectomy (RP) or radiotherapy (RT) in a prospective study. SUBJECTS AND METHODS: In 103 relapsing patients after RP (n=97) or RT (n=6) AC-PET images and CT scans were obtained. In PET positive patients with localized recurrence detected lesions were resected and histologically verified or -after local RT- followed-up by PSA testing...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27834643/visualization-of-deformable-image-registration-quality-using-local-image-dissimilarity
#17
Matthias Schlachter, Tobias Fechter, Miro Jurisic, Tanja Schimek-Jasch, Oliver Oehlke, Sonja Adebahr, Wolfgang Birkfellner, Ursula Nestle, Katja Bu Hler
Deformable image registration (DIR) has the potential to improve modern radiotherapy in many aspects, including volume definition, treatment planning and image-guided adaptive radiotherapy. Studies have shown its possible clinical benefits. However, measuring DIR accuracy is difficult without known ground truth, but necessary before integration in the radiotherapy workflow. Visual assessment is an important step towards clinical acceptance. We propose a visualization framework which supports the exploration and the assessment of DIR accuracy...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27823640/impact-of-pet-ct-on-radiation-treatment-in-patients-with-esophageal-cancer-a-systematic-review
#18
REVIEW
Jing Lu, Xiang-Dong Sun, Xi Yang, Xin-Yu Tang, Qin Qin, Hong-Cheng Zhu, Hong-Yan Cheng, Xin-Chen Sun
PURPOSE: With the advances in radiotracers, positron emission tomography/computed tomography (PET/CT) is recognized as a useful adjunct to anatomic imaging with CT, MRI and endoscopic ultrasonography (EUS). The objective of this review was to comprehensively analyze the roles of PET/CT for the radiotherapy of esophageal cancer. METHODS: In this review, we focused on issues concerning the application of PET/CT in TNM staging, target volume delineation and response to therapy, both for the primary tumor and regional lymph nodes...
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27815727/initial-experiments-with-gel-water-towards-mri-linac-dosimetry-and-imaging
#19
Sarah J Alnaghy, Maegan Gargett, Gary Liney, Marco Petasecca, Jarrad Begg, Anthony Espinoza, Matthew K Newall, Mitchell Duncan, Lois Holloway, Michael L F Lerch, Mircea Lazea, Anatoly B Rosenfeld, Peter Metcalfe
Tracking the position of a moving radiation detector in time and space during data acquisition can replicate 4D image-guided radiotherapy (4DIGRT). Magnetic resonance imaging (MRI)-linacs need MRI-visible detectors to achieve this, however, imaging solid phantoms is an issue. Hence, gel-water, a material that provides signal for MRI-visibility, and which will in future work, replace solid water for an MRI-linac 4DIGRT quality assurance tool, is discussed. MR and CT images of gel-water were acquired for visualisation and electron density verification...
November 4, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27810195/transrectal-implantation-and-stability-of-gold-markers-in-prostate-bed-for-salvage-radiotherapy-of-macroscopic-recurrences
#20
Shakir I Shakir, Corina Udrescu, Ciprian Enachescu, Olivier Rouviere, Simona Arion, Ionela Caraivan, Olivier Chapet
BACKGROUND AND PURPOSE: The objective of the study was to verify the stability of gold markers in the prostatic bed (PB) during salvage radiotherapy. MATERIAL AND METHODS: Seven patients, diagnosed with a macroscopic nodule visible on MRI, underwent targeted MRI-guided biopsies. Three gold markers were implanted into the PB close to the relapsing nodule for CT/MRI fusion. A dose of 60Gy was delivered using IMRT to the PB followed by a dose escalation up to 72Gy to the macroscopic nodule...
November 2016: Physica Medica: PM
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