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https://www.readbyqxmd.com/read/29764969/cardiovascular-phenotype-and-prognosis-of-patients-with-heart-failure-induced-by-cancer-therapy
#1
Wilson Nadruz, Erin West, Morten Sengeløv, Gabriela L Grove, Mário Santos, John D Groarke, Daniel E Forman, Brian Claggett, Hicham Skali, Anju Nohria, Amil M Shah
OBJECTIVE: This study compared the clinical features, cardiac structure and function evaluated by echocardiography, cardiopulmonary response to exercise and long-term clinical outcomes between patients with heart failure (HF) induced by cancer therapy (CTHF) and heart failure not induced by cancer therapy (NCTHF). METHODS: We evaluated 75 patients with CTHF and 894 with NCTHF who underwent clinically indicated cardiopulmonary exercise testing, and followed these individuals for a median of 4...
May 15, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#2
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29757824/improvements-in-key-cardiopulmonary-exercise-testing-variables-following-cardiac-rehabilitation-in-patients-with-coronary-artery-disease
#3
Dejana Popovic, Nikhil Kumar, Sundeep Chaudhry, Akshay Bagai, Ross Arena, Naresh Kumar
PURPOSE: Improvements in cardiorespiratory fitness (VO2peak) post-cardiac rehabilitation (post-CR) are used to gauge therapeutic efficacy. The aim of the present study was to assess the effect of supervised CR on other cardiopulmonary exercise testing (CPX) variables, specifically those that reflect ventilatory efficiency and VO2 changes in relation to changes in work rate (WR). METHODS: Patients (n = 142; mean age 63 ± 9 y; 23% female) with coronary artery disease (CAD) participated in supervised CR for 3 to 6 mo completing 60 ± 17 sessions (range: 32-96 sessions), with intensity derived from the baseline CPX...
May 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29746386/whole-body-high-intensity-interval-training-induce-similar-cardiorespiratory-adaptations-compared-with-traditional-high-intensity-interval-training-and-moderate-intensity-continuous-training-in-healthy-men
#4
Gustavo Z Schaun, Stephanie S Pinto, Mariana R Silva, Davi B Dolinski, Cristine L Alberton
Schaun, GZ, Pinto, SS, Silva, MR, Dolinski, DB, and Alberton, CL. Sixteen weeks of whole-body high-intensity interval training induce similar cardiorespiratory responses compared with traditional high-intensity interval training and moderate-intensity continuous training in healthy men. J Strength Cond Res XX(X): 000-000, 2018-Low-volume high-intensity interval training (HIIT) protocols that use the body weight as resistance could be an interesting and inexpensive alternative to traditional ergometer-based high-intensity interval training (HIIT-T) and moderate-intensity continuous training (MICT)...
May 7, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29745970/mechanical-efficiency-of-high-versus-moderate-intensity-aerobic-exercise-in-coronary-heart-disease-patients-a-randomized-clinical-trial
#5
Koldobika Villelabeitia-Jaureguizar, Davinia Vicente-Campos, Alejandro Berenguel Senen, Verónica Verónica Hernández Jiménez, Lorena Lorena Ruiz Bautista, María Elvira Barrios Garrido-Lestache, Jose López Chicharro
BACKGROUND: Mechanical efficiency (ME) refers to the ability of an individual to transfer energy consumed by external work. A decreased ME, could represent an increased energy cost during exercise and may, therefore, be limited in terms of physical activity. This study aimed to compare the influence of two different exercise protocols: moderate continuous training (MCT) versus high intensity interval training (HIIT), as part of a cardiac rehabilitation program on ME values among coronary patients...
May 10, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29732178/femoro-jugular-cannulation-in-veno-venous-extracorporeal-membrane-oxygenation-pro-con
#6
REVIEW
Martina Crivellari, Federico Pappalardo
Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is the most efficient technique for respiratory support. It is based on a patient adequate circulation and cardiac function and it is indicated for isolated lung failure after optimization of the ventilatory support and the medical treatment. We describe PRO and CONs of the Femoro-jugular (F>J) approach, as an ideal setting for patients which require high flow (>5 L/min), such as those with extreme hypoxemia and/or septic shock. This technique can be accomplished very quickly at the bedside also in an unstable patient...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29730330/water-based-aerobic-training-improves-strength-parameters-and-cardiorespiratory-outcomes-in-elderly-women
#7
Rochelle Rocha Costa, Ana Carolina Kanitz, Thais Reichert, Alexandre Konig Garcia Prado, Leandro Coconcelli, Adriana Cristine Koch Buttelli, Laura Frances Pereira, Marcos Paulo Bienert Masiero, Andressa Pellegrini Meinerz, Matheus Oliveira Conceição, Isadora Loch Sbeghen, Luiz Fernando Martins Kruel
The aim of the present study was to compare the effects of water-based aerobic training and water-based resistance training on muscular strength and cardiorespiratory fitness in older women. Sixty-nine individuals were randomized into the following three groups: the water-based aerobic training (WA, n = 23) group, the water-based resistance training (WR, n = 23) group, and the control group (CG, n = 23). Participants were trained two times per week for 10 weeks. The trainings presented a linear periodization with an increase in the volume-intensity relation...
May 3, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29729860/is-ventilatory-therapy-combined-with-exercise-training-effective-in-patients-with-heart-failure-and-sleep-disordered-breathing-results-of-a-randomized-trial-during-a-cardiac-rehabilitation-programme-satelit-hf
#8
Marie-Christine Iliou, Sonia Corone, Barnabas Gellen, Thierry Denolle, Frederic Roche, Anaïs Charles Nelson, Christian Darné
BACKGROUND: Sleep-related disordered breathing is common in patients with chronic heart failure. AIM: To assess the efficacy of short-term nocturnal ventilatory therapy combined with exercise training (V+ET) compared with exercise training alone (ET) in patients with chronic heart failure with sleep-disordered breathing. METHODS: Patients in New York Heart Association functional class II-IIIb, with an apnoea-hypopnoea index (AHI)>15/h, and enrolled in a cardiac rehabilitation programme, were centrally randomized to V+ET or ET...
May 2, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29706718/comparison-of-two-instructions-for-deep-breathing-exercise-non-specific-and-diaphragmatic-breathing
#9
Masami Yokogawa, Tomoyo Kurebayashi, Toshikazu Ichimura, Manabu Nishino, Hiroichi Miaki, Takao Nakagawa
[Purpose] Breathing exercises are frequently prescribed to reduce pulmonary complications after abdominal and thoracic surgery. Appropriate instructions ensuring the integrity of the self-exercise are important. This study compared the effects of two instructions, focusing on non-specific breathing (NB) and diaphragmatic breathing (DB) patterns, respectively, on the ventilatory efficiency and work of breathing. [Subjects and Methods] The participants were healthy men (n=15) and women (n=15). Ventilatory parameters, heart rate, and autonomic nervous system activity were measured during natural and deep breathing phases performed under the two instructions (NB and DB), with the deep breathing phase following the natural breathing phase...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29689105/cerebral-desaturation-in-heart-failure-potential-prognostic-value-and-physiologic-basis
#10
Yu-Jen Chen, Jong-Shyan Wang, Chih-Chin Hsu, Pyng-Jing Lin, Feng-Chun Tsai, Ming-Shien Wen, Chi-Tai Kuo, Shu-Chun Huang
Cerebral tissue oxygen saturation (SctO2) reflects cerebral perfusion and tissue oxygen consumption, which decline in some patients with heart failure with reduced ejection fraction (HFrEF) or stroke, especially during exercise. Its physiologic basis and clinical significance remain unclear. We aimed to investigate the association of SctO2 with oxygen transport physiology and known prognostic factors during both rest and exercise in patients with HFrEF or stroke. Thirty-four HFrEF patients, 26 stroke patients, and 17 healthy controls performed an incremental cardiopulmonary exercise test using a bicycle ergometer...
2018: PloS One
https://www.readbyqxmd.com/read/29663436/early-effects-of-empagliflozin-on-exercise-tolerance-in-patients-with-heart-failure-a-pilot-study
#11
Julio Núñez, Patricia Palau, Eloy Domínguez, Anna Mollar, Eduardo Núñez, Jose María Ramón, Gema Miñana, Enrique Santas, Lorenzo Fácila, Jose Luis Górriz, Juan Sanchis, Antoni Bayés-Genís
BACKGROUND: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising therapy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack of data endorsing its role in symptomatic HF patients. We sought to evaluate the short-term effects of empagliflozin on maximal exercise capacity in these patients. HYPOTHESIS: We postulate tretament with empagliflozin may improve functional capacity in patients with T2DM and established HF...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29618551/computer-simulations-show-that-neanderthal-facial-morphology-represents-adaptation-to-cold-and-high-energy-demands-but-not-heavy-biting
#12
Stephen Wroe, William C H Parr, Justin A Ledogar, Jason Bourke, Samuel P Evans, Luca Fiorenza, Stefano Benazzi, Jean-Jacques Hublin, Chris Stringer, Ottmar Kullmer, Michael Curry, Todd C Rae, Todd R Yokley
Three adaptive hypotheses have been forwarded to explain the distinctive Neanderthal face: (i) an improved ability to accommodate high anterior bite forces, (ii) more effective conditioning of cold and/or dry air and, (iii) adaptation to facilitate greater ventilatory demands. We test these hypotheses using three-dimensional models of Neanderthals, modern humans, and a close outgroup ( Homo heidelbergensis ), applying finite-element analysis (FEA) and computational fluid dynamics (CFD). This is the most comprehensive application of either approach applied to date and the first to include both...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29523922/a-novel-mechanism-for-improved-exercise-performance-in-pediatric-fontan-patients-after-cardiac-rehabilitation
#13
Samuel Wittekind, Wayne Mays, Yvette Gerdes, Sandra Knecht, John Hambrook, William Border, John Lynn Jefferies
Patients with a Fontan circulation have impaired exercise capacity. Cardiac rehabilitation (CR) has shown promise in enhancing peak exercise parameters in this population, but an improvement in submaximal exercise has not been consistently demonstrated. We assessed the hypothesis that participation in CR will be associated with more efficient oxygen extraction and ventilation during submaximal exercise. In this prospective study, pediatric Fontans completed two 60 min CR sessions per week for 12 weeks. Cardiopulmonary exercise testing and stress echocardiography were performed at baseline and last CR session, and then compared with a paired sample t test...
June 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29519728/optimizing-risk-stratification-in-heart-failure-and-the-selection-of-candidates-for-heart-transplantation
#14
Tiago Pereira-da-Silva, Rui M Soares, Ana Luísa Papoila, Iola Pinto, Joana Feliciano, Luís Almeida-Morais, Ana Abreu, Rui Cruz Ferreira
INTRODUCTION AND AIMS: Selecting patients for heart transplantation is challenging. We aimed to identify the most important risk predictors in heart failure and an approach to optimize the selection of candidates for heart transplantation. METHODS: Ambulatory patients followed in our center with symptomatic heart failure and left ventricular ejection fraction ≤40% prospectively underwent a comprehensive baseline assessment including clinical, laboratory, electrocardiographic, echocardiographic, and cardiopulmonary exercise testing parameters...
February 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29512020/noninvasive-auto-titrating-ventilation-avaps-ae-versus-average-volume-assured-pressure-support-avaps-ventilation-in-hypercapnic-respiratory-failure-patients
#15
Gul Gursel, Avsar Zerman, Burcu Basarik, Kamil Gonderen, Muge Aydogdu, Serriyye Memmedova
Auto-titrating noninvasive ventilation (NIV) has been developed as a new mode applying variable expiratory-positive airway pressure (EPAP) in addition to variable inspiratory pressures (IPAP), both to deliver targeted tidal volume (VT) and to eliminate upper airway resistance. The purpose of this study is to evaluate whether NIV with auto-titrating mode will decrease more PaCO2 within a shorter time compared to volume-assured mode in hypercapnic intensive care unit (ICU) patients. The hypercapnic respiratory failure patients treated with average volume assured pressure support- automated EPAP mode (group1) were compared with those treated with average volume-assured pressure support mode (group2)...
April 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29433335/relationship-between-the-prognostic-value-of-ventilatory-efficiency-and-age-in-patients-with-heart-failure
#16
Yuko Kato, Shinya Suzuki, Tokuhisa Uejima, Hiroaki Semba, Osamu Nagayama, Etsuko Hayama, Takuto Arita, Naoharu Yagi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Yuji Oikawa, Takashi Kunihara, Junji Yajima, Takeshi Yamashita
Background Ventilatory efficiency decreases with age. This study aimed to investigate the prognostic significance and cut-off value of the minute ventilation/carbon dioxide production (VE/VCO2 ) slope according to age in patients with heart failure. Methods and results We analysed 1501 patients with heart failure from our observational cohort who performed maximal symptom-limited cardiopulmonary exercise testing and separated them into three age groups (≤55 years, 56-70 years and ≥71 years) in total and according to the three ejection fraction categories defined by European Society of Cardiology guidelines...
May 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29430444/heart-lung-interactions-in-acute-respiratory-distress-syndrome-pathophysiology-detection-and-management-strategies
#17
REVIEW
Fernando Suarez Sipmann, Arnoldo Santos, Gerardo Tusman
Acute respiratory distress syndrome (ARDS) is the most severe form of acute respiratory failure characterized by diffuse alveolar and endothelial damage. The severe pathophysiological changes in lung parenchyma and pulmonary circulation together with the effects of positive pressure ventilation profoundly affect heart lung interactions in ARDS. The term pulmonary vascular dysfunction (PVD) refers to the specific involvement of the vascular compartment in ARDS and is expressed clinically by an increase in pulmonary arterial (PA) pressure and pulmonary vascular resistance both affecting right ventricular (RV) afterload...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29425566/functional-outcome-in-contemporary-children-with-total-cavopulmonary-connection-health-related-physical-fitness-exercise-capacity-and-health-related-quality-of-life
#18
Julia Hock, Barbara Reiner, Rhoia C Neidenbach, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller
OBJECTIVE: Children and adolescents with an univentricular heart after total cavopulmonary connection (TCPC) have functional impairments. This study assesses health-related physical fitness (HRPF) and exercise capacity, as well as their relation to health-related quality of life (HRQoL) in patients with an univentricular heart after total-pulmonary connection (TCPC). PATIENTS AND METHODS: Between July 2014 and October 2016 a total of 78 children and adolescents with TCPC (12...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29408567/influence-of-high-intensity-interval-training-on-ventilatory-efficiency-in-trained-athletes
#19
Eduardo Salazar-Martínez, Alfredo Santalla, José Naranjo Orellana, Jochen Strobl, Martin Burtscher, Verena Menz
The aim of this study was to investigate the effects of 3 weeks high-intensity interval training (HIIT) on ventilatory efficiency (VE /VCO2 slope) in endurance athletes. Sixteen male well-trained (67.72 ml kg min-1 ) athletes participated in this study. Each participant performed an incremental exercise test with gas analysis (i.e. VE , VO2 ) and a 400 m running field test (T400m) before and after the 3 weeks intervention period. HIIT group (HIITG) performed 11 HIIT sessions consisting of four 4-min interval bouts at an exercise intensity of 90-95% of the VO2max , separated by 4-min active recovery periods (work/rest ratio = 1:1)...
April 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29349536/oxygen-uptake-efficiency-slope-and-prediction-of-post-operative-morbidity-and-mortality-in-patients-with-lung-cancer
#20
Sertaç Yakal, Sevtün Sofyalı, Berker Özkan, Safinaz Yıldız, Alper Toker, Erdem Kasikcioglu
OBJECTIVE: Peak oxygen consumption is a very valuable cardiopulmonary functional parameter in pre-operative evaluation of patients with lung cancer. However, it has several critical limitations for operability decision due to failure in achieving maximal level of exercise test for cases. The aim of this study was to reveal the importance of more accurate cardiopulmonary parameters that can be calculated from data of submaximal level test, such as oxygen uptake efficiency slope (OUES) and to determine whether it could be used in the operability decision phase for borderline cases by means of morbidity and mortality...
April 2018: Lung
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