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CSVD executive function

C Eleana Zhang, Sau May Wong, Renske Uiterwijk, Walter H Backes, Jacobus F A Jansen, Cécile R L P N Jeukens, Robert J van Oostenbrugge, Julie Staals
Blood-brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship between BBB leakage and white matter hyperintensity (WMH) volume and cognition, in cSVD patients and healthy controls. Seventy-seven patients with clinically overt cSVD and thirty-nine age matched healthy controls underwent dynamic contract-enhanced and structural brain MRI and neuropsychological assessment. We quantified BBB leakage volume and rate in normal appearing white matter (NAWM), WMH and cortical grey matter (CGM)...
March 23, 2018: Brain Imaging and Behavior
Ayan K Dey, Vessela Stamenova, Gary Turner, Sandra E Black, Brian Levine
INTRODUCTION: Cerebral small vessel disease (CSVD) is a highly prevalent condition associated with diffuse ischemic damage and cognitive dysfunction particularly in executive function and attention. Functional brain imaging studies can reveal mechanisms of cognitive impairment in CSVD, although findings are mixed. METHODS: A systematic review integrating findings from functional magnetic resonance imaging and electroencephalography in CSVD is involved. RESULTS: CSVD damages long-range white matter tracts connecting nodes within distributed brain networks...
July 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Peter Hermann, Carlos Romero, Christian Schmidt, Clemens Reis, Inga Zerr
Despite existing criteria, differential diagnosis of Vascular Dementia (VD) and Alzheimer's disease (AD) remains difficult. The aim of this study is to figure out cognitive and biomarker profiles that may help to distinguish between VD, AD and AD + Cerebral Small Vessel Disease (CSVD). We examined a cohort of patients with CSVD (n = 92). After stratification of cognitive impaired patients (n = 59) using the standard CSF beta-amyloid 42/40 ratio cut-off point of 0.975, we obtained two groups which differed with respect to several features: 32 patients with normal beta-amyloid 42/40 ratio (>0...
2014: PloS One
Marjolein Huijts, Annelien Duits, Robert J van Oostenbrugge, Abraham A Kroon, Peter W de Leeuw, Julie Staals
BACKGROUND: White matter lesions (WMLs), asymptomatic lacunar infarcts, brain microbleeds (BMBs), and enlarged perivascular spaces (EPVS) have been identified as silent lesions due to cerebral small vessel disease (cSVD). All these markers have been individually linked to cognitive functioning, but are also strongly correlated with each other. The combined effect of these markers on cognitive function has never been studied and would possibly provide more useful information on the effect on cognitive function...
2013: Frontiers in Aging Neuroscience
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