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Thoracic complications bone marrow transplant

Juan Carlos Aldave Becerra, Enrique Cachay Rojas
We report a 3-year-old Peruvian girl, born to non-consanguineous parents. At the age of 8 months, she had a severe pneumonia complicated with empyema that required thoracic drainage and mechanical ventilation. Although no microorganisms were isolated, the patient recovered with broad-spectrum antibiotics. Since that date, she has presented multiple episodes of pneumonia and recurrent episodes of bronchospasm. At 1 year 5 months of age, the patient began with recurrent episodes of oropharyngeal, vaginal, and skin candidiasis, which improved transiently after using oral azole drugs...
2017: Frontiers in Pediatrics
Song Gao, Zhiying Zhao, Rong Wu, Yuecan Zeng, Zhenyong Zhang, Jianing Miao, Zhengwei Yuan
Radiotherapy is an effective form of therapy for most thoracic malignant tumors. However, myocardial injury resulting from the high doses of radiation is a severe complication. Here we aimed to study the possibility of reducing radiation-induced myocardial injury with mesenchymal stem cell (MSC) transplantation. We used MSCs extracted from bone marrow (BMSCs) to transplant via the tail vein into a radiation-induced heart injury (RIHI) rat model. The rats were divided into six groups: a Sham group, an IRR (irradiation) group, and four IRR + BMSCs transplantation groups obtained at different time points...
March 2017: Radiation and Environmental Biophysics
Karina Portillo, Ignasi Guasch, Caroline Becker, Felipe Andreo, Maria Teresa Fernández-Figueras, José Ramirez Ruz, Carlos Martinez-Barenys, Samuel García-Reina, Pedro Lopez de Castro, Irene Sansano, Ana Villar, Juan Ruiz-Manzano
Pleuroparenchymal fibroelastosis (PPFE) is a rare entity that has been recently included in the official American Thoracic Society/European Respiratory Society (ATS/ERS) statement in 2013 as a group of rare idiopathic interstitial pneumonias (IIPs). PPFE is characterized by pleural and subpleural parenchymal thickening due to elastic fiber proliferation, mainly in the upper lobes. The etiology of the disease is unclear, although some cases have been associated as a complication after bone marrow transplantation, lung transplantation (LT), chemotherapy, and recurrent respiratory infections...
2015: Case Reports in Pulmonology
Mark Amsbaugh, Matthew Bertke, Alexandra Cheerva, Craig Silverman
Cancer Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Stereotactic Body Radiation Therapy (SBRT) delivers a high dose of radiation to a small volume over limited fractions. It is a viable treatment for localized lung cancer and oligometistatic pulmonary disease in adults, however, its role is not known in the pediatric population.CASE PRESENTATION: T.S. is a 14-year-old boy, diagnosed with Ewing's Sarcoma of the left acetabulum with pulmonary metastases...
October 1, 2014: Chest
Francesco Petrella, Francesca Toffalorio, Stefano Brizzola, Tommaso Martino De Pas, Stefania Rizzo, Massimo Barberis, Piergiuseppe Pelicci, Lorenzo Spaggiari, Fabio Acocella
BACKGROUND: Bronchopleural fistula after lung resection still represents a challenging life-threatening complication for thoracic surgeons. Considering its extremely high mortality rate, an effective treatment is urgently required. Our project investigated the hypothesis of experimental bronchopleural fistula closure by bronchoscopic injection of autologous bone marrow-derived mesenchymal stem cells into the cavity of the fistula, evaluating its feasibility and safety in a large animal model...
February 2014: Annals of Thoracic Surgery
José M García Santos, Miguel Blanquer, Silvia Torres del Río, Francisca Iniesta, Joaquín Gomez Espuch, Miguel Ángel Pérez-Espejo, Salvador Martínez, José M Moraleda
OBJECTIVE: To report MRI spinal changes after surgical infusion of bone marrow stem cells (BMSc) in ALS patients and assess their correlation with clinical events and functional performance. METHODS: BMSc were surgically injected in the thoracic spinal cord of 11 ALS patients (6/5 male/female; median age 46years). We performed first-week and third, sixth, ninth and twelfth post-surgical months spinal MRIs. The spinal changes in the postsurgical week and follow-up MRIs, as well as clinical events, functional scales and respiratory and electromyography data, were longitudinally monitored...
October 2013: Magnetic Resonance Imaging
Ulrich Tigges, Masanobu Komatsu, William B Stallcup
Restenosis is a major complication of coronary angioplasty, at least partly due to the fact that the origin and identity of contributing cell types are not well understood. In this study, we have investigated whether pericyte-like cells or mesenchymal stem cells (MSCs) from the adventitia contribute to restenosis. We demonstrate that while cells expressing the pericyte markers NG2, platelet-derived growth factor receptor β, and CD146 are rare in the adventitia of uninjured mouse femoral arteries, following injury their numbers strongly increase...
2013: Journal of Vascular Research
Emily Z Keung, Xiaoxia Liu, Afrin Nuzhad, Guilherme Rabinowits, Vihas Patel
BACKGROUND: Although percutaneous endoscopic gastrostomy (PEG) is widely performed for nutrition or palliation, PEG-associated outcomes in cancer patients remain poorly described. We examined the safety and benefits of PEG placement in this population at our institution. STUDY DESIGN: A 5-year retrospective review of patients with malignancy (excluding head/neck and thoracic malignancy) who underwent PEG at our institution was performed. RESULTS: One hundred and eighty-nine patients with malignancy underwent PEG; 33...
December 2012: Journal of the American College of Surgeons
Vamsi V Nagineni, Andrew R James, Marjan Alimi, Christoph Hofstetter, Benjamin J Shin, Innocent Njoku, Apostolos John Tsiouris, Roger Härtl
STUDY DESIGN: Retrospective study. OBJECTIVE: To assess the clinical and radiographical outcomes in spinal fusion procedures using silicate-substituted calcium phosphate (Si-CaP). SUMMARY OF BACKGROUND DATA: Si-CaP is a newer-generation synthetic ceramic designed to maximize osteoinduction and osteoconduction. METHODS: This is a retrospective analysis of a prospectively collected patient database including 108 patients (204 individual spinal levels)...
September 15, 2012: Spine
Saeid Karamouzian, Seyed Noureddin Nematollahi-Mahani, Nozar Nakhaee, Hossein Eskandary
BACKGROUND: In recent years, some studies were conducted to evaluate the effects of stem cells from different sources on patients with spinal cord injury (SCI). This study was carried out to evaluate the feasibility and therapeutic potential of autologous bone marrow cell (BMC) transplantation in 11 complete spinal cord injured patients at thoracic level. METHODS AND MATERIALS: This nonrandomized clinical trial compared the results of autologous BMC transplantation into cerebrospinal fluid (CSF) via lumbar puncture (LP) in 11 patients having complete SCI, with 20 patients as control group who received conventional treatment without BMC transplantation...
September 2012: Clinical Neurology and Neurosurgery
Khalid A M Alsaleh, Caroline A Tougas, Darren M Roffey, Eugene K Wai
STUDY DESIGN: A systematic review. OBJECTIVE: To evaluate the efficacy, safety, and outcomes of osteoconductive bone graft extenders (BGEs) compared with iliac crest bone graft (ICBG) in posterolateral thoracolumbar spinal fusion. SUMMARY OF BACKGROUND DATA: ICBG is the current "gold standard" for achieving spinal arthrodesis. However, morbidity associated with its harvesting has led to the increased use of BGEs. METHODS: An electronic literature search was conducted through April 2011 using MEDLINE, EMBASE, CENTRAL, and Cochrane Library...
July 15, 2012: Spine
Angela Panoskaltsis-Mortari, Matthias Griese, David K Madtes, John A Belperio, Imad Y Haddad, Rodney J Folz, Kenneth R Cooke
RATIONALE: Acute lung dysfunction of noninfectious etiology, known as idiopathic pneumonia syndrome (IPS), is a severe complication following hematopoietic stem cell transplantation (HSCT). Several mouse models have been recently developed to determine the underlying causes of IPS. A cohesive interpretation of experimental data and their relationship to the findings of clinical research studies in humans is needed to better understand the basis for current and future clinical trials for the prevention/treatment of IPS...
May 1, 2011: American Journal of Respiratory and Critical Care Medicine
Nobuo Tsunooka, Shin Hirayama, Jeffrey A Medin, W Conrad Liles, Shaf Keshavjee, Thomas K Waddell
BACKGROUND: Transfer of viable tissue flaps and thoracoplasty are effective against pleural space complications after pneumonectomy but highly disfiguring. The aim of this study was to explore the possibility of engineered tissue to treat space complications after pneumonectomy. METHODS: A left pneumonectomy was performed in mice, and the cavity immediately filled with the cellularized collagen matrices. First, bone marrow derived-mesenchymal stroma cells with luciferase expression were used as donor cells to evaluate cell viability and angiogenesis using bioluminescence imaging...
March 2011: Annals of Thoracic Surgery
David Gomez-de-Antonio, Mercedes Zurita, Martin Santos, Isabel Salas, Jesús Vaquero, Andres Varela
OBJECTIVE: Bronchial stump dehiscence is still the most feared complication for the thoracic surgeon, with mortality rates ranging from 25% to 75%. This study reports the histologic effect of adult stem cells in the healing process of the bronchial stump after lung resection. METHODS: A left pneumonectomy was performed in 36 Wistar rats. Half of them received previously labeled bone marrow-derived stem cells applied to the bronchial stump. In each group, 7 rats were sacrificed on day 7 and 11 rats were sacrificed on day 21...
December 2010: Journal of Thoracic and Cardiovascular Surgery
Suken A Shah, Battugs Borkhuu, Aaron G Littleton, Marc S Keller, Victoria Kuester, George R Dodge
STUDY DESIGN: Nonrandomized consecutive case series comparing interbody spine fusion with autograft versus bone marrow-based graft replacement (BGR). OBJECTIVES: Effectiveness of bone marrow-based graft versus rib autograft in achieving anterior interbody fusion of the thoracolumbar/lumbar spine. SUMMARY OF BACKGROUND DATA: The use of bone marrow (BM) with graft materials was shown in a prior study to aid with bone regeneration. Limited clinical data are currently available to demonstrate the effectiveness of BM for spinal applications...
February 2010: Journal of Spinal Disorders & Techniques
Yukari Asai, Hiroshi Ouchi, Tukasa Ohosima, Ryuji Nakano, Yujiro Yamano, Ichiro Inoshima, Takuji Yamauchi, Satoshi Fukuyama, Hiromasa Inoue, Yoichi Nakanishi
A 27-year-old man was admitted to our hospital complaining of a persistent high fever since August 2007. Chest radiography showed infiltration shadows in the right lower lung field. Chest CT revealed scattered small nodular shadows and patchy consolidations in the right lower lobe. He was diagnosed as secondary pulmonary alveolar proteinosis (sPAP) associated with myelodysplastic syndrome (MDS), confirmed by video-assisted thoracic surgery (VATS) and bone marrow aspiration. Sera were negative for anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody...
December 2009: Nihon Kokyūki Gakkai Zasshi, the Journal of the Japanese Respiratory Society
S Jimenez-Galanes Marchan, J C Meneu Díaz, O Caso Maestro, B Perez Saborido, A Moreno Elola-Olaso, M Abradelo Usera, Y Fundora Suarez, A Gimeno Calvo, V Moreno Molinero, A Garcia Reyne, V Barra Valencia, R San Juan Garrido, E Moreno Gonzalez
Nocardiosis is an infrequent disease that affects patients who display a cellular immunodeficiency, such as transplant recipients on immunosuppressive treatment, but uncommonly associated with high morbidity and mortality rates. Disseminated Nocardiosis affecting the central nervous system (CNS), abdomen, skin, and lungs has been described in bone marrow, lung, and kidney transplant recipients. However, to our knowledge, no cases involving all of these structures have been reported in liver transplant recipients...
July 2009: Transplantation Proceedings
Ori Efrati, Udi Sadeh-Gornik, Dalit Modan-Moses, Asher Barak, Amir Szeinberg, Amir Vardi, Gidon Paret, Amos Toren, Daphna Vilozni, Yaacov Yahav
OBJECTIVE: The use of flexible bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in investigating pediatric patient with airway abnormalities and pulmonary infiltrates are indispensable and are now a routine procedure in many centers. Immunocompromised and cancer patients, especially after bone marrow transplantation, and children who have undergone surgery for congenital heart disease (CHD) are at high risk for pulmonary disease. Our aim was to study the diagnostic rate, safety, and clinical yield of FOB in critically ill pediatric patients...
January 2009: Pediatric Critical Care Medicine
Hans Jürgen Dornbusch, Petra Sovinz, Herwig Lackner, Wolfgang Schwinger, Martin Benesch, Volker Strenger, Christian Urban
Due to unacceptably high mortality, invasive fungal infections (IFI) have long been considered a contraindication against allogeneic stem cell transplantation. Despite severe immunosuppression an 11-year-old girl requiring allogeneic bone marrow transplant (BMT) for relapsed acute lymphoblastic leukemia was cured of a concurrent invasive pulmonary aspergillosis. Treatment comprised combinations of liposomal amphotericin B, caspofungin and voriconazole with donor granulocyte transfusions. This therapeutic regimen, including the choice of reduced intensity conditioning (RIC), allowed the patient to receive an allogeneic BMT...
August 2008: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Gergely Kriván, János Sinkó, Ildikó Zsolnai Nagy, Vera Goda, Péter Reményi, Arpád Bátai, Sándor Lueff, Balázs Kapás, Marienn Réti, Anna Tremmel, Tamás Masszi
The emergence of new antifungal compounds with alternative mechanisms of action and improved tolerability has opened up new therapeutic possibilities for the use of combined antifungal treatment in life-threatening systemic fungal infections. A case report of an 8-year-old allogeneic stem cell transplant recipient who developed a central venous catheter tunnel infection caused by Aspergillus flavus is presented here. In spite of conventional and subsequent liposomal amphotericin B therapy the infection progressed rapidly and the necrosis extended further to the thoracic wall, pleura and the right lung...
2006: Acta Bio-medica: Atenei Parmensis
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