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parkinso* AND (Rho kinase OR rock)

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https://www.readbyqxmd.com/read/27772760/role-of-rho-mediated-rock-semaphorin3a-signaling-pathway-in-the-pathogenesis-of-parkinson-s-disease-in-a-mouse-model
#1
Li Qi, Yong-Gang Tang, Lin Wang, Wei He, Hong-Hua Pan, Rong-Rong Nie, Yan Can
OBJECTIVE: The present study aims to elucidate the role of Rho-mediated ROCK-Semaphorin3A signaling pathway in the pathogenesis of Parkinson's disease (PD) in a mouse model. METHODS: One-hundred twelve eight-week male C57BL/6 mice were selected. The mouse model of PD was constructed by intraperitoneal injection of MPTP. All mice were divided into four groups (28 mice in each group): Blank group, Model group, Rho knockout (Rho+/-) group and ROCK knockout (ROCK+/-) group...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27541019/the-rock-ggtase-pathway-are-essential-to-the-proliferation-and-differentiation-of-neural-stem-cells-mediated-by-simvastatin
#2
Chan Zhang, Jian-Min Wu, Min Liao, Jun-Ling Wang, Chao-Jin Xu
Simvastatin, a lipophilic and fermentation-derived natural statin, is reported to treat neurological disorders, such as traumatic brain injury, Parkinson's disease (PD), Alzheimer disease (AD), etc. Recently, research also indicated that simvastatin could promote regeneration in the dentate gyrus of adult mice by Wnt/β-catenin signaling (Robin et al. in Stem Cell Reports 2:9-17, 2014). However, the effect and mechanisms by which simvastatin may affect the neural stem cells (NSCs; from the embryonic day 14...
December 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27234991/erratum-to-behavioural-effects-of-basal-ganglia-rho-kinase-inhibition-in-the-unilateral-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#3
Salim Yalcin Inan, Burak Cem Soner, Ayse Saide Sahin
No abstract text is available yet for this article.
May 28, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27101974/fasudil-attenuates-aggregation-of-%C3%AE-synuclein-in-models-of-parkinson-s-disease
#4
Lars Tatenhorst, Katrin Eckermann, Vivian Dambeck, Luis Fonseca-Ornelas, Hagen Walle, Tomás Lopes da Fonseca, Jan C Koch, Stefan Becker, Lars Tönges, Mathias Bähr, Tiago F Outeiro, Markus Zweckstetter, Paul Lingor
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. Since alpha-synuclein (α-Syn) aggregation is a major hallmark in the pathogenesis of PD, we aimed to evaluate the anti-aggregative potential of pharmacological ROCK inhibition using the isoquinoline derivative Fasudil, a small molecule inhibitor already approved for clinical use in humans...
April 22, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27075764/effects-of-rho-kinase-inhibitors-on-grafts-of-dopaminergic-cell-precursors-in-a-rat-model-of-parkinson-s-disease
#5
Jannette Rodriguez-Pallares, Ana I Rodriguez-Perez, Ana Muñoz, Juan A Parga, Juan J Toledo-Aral, Jose L Labandeira-Garcia
UNLABELLED: In models of Parkinson's disease (PD), Rho kinase (ROCK) inhibitors have antiapoptotic and axon-stabilizing effects on damaged neurons, decrease the neuroinflammatory response, and protect against dopaminergic neuron death and axonal retraction. ROCK inhibitors have also shown protective effects against apoptosis induced by handling and dissociation of several types of stem cells. However, the effect of ROCK inhibitors on dopaminergic cell grafts has not been investigated...
June 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27033194/rock-in-cns-different-roles-of-isoforms-and-therapeutic-target-for-neurodegenerative-disorders
#6
Cheong-Meng Chong, Nana Ai, Simon Ming-Yuen Lee
Rho-associated protein kinase (ROCK) is a serine-threonine kinase originally identified as a crucial regulator of actin cytoskeleton. Recent studies have defined new functions of ROCK as a critical component of diverse signaling pathways in neurons. In addition, inhibition of ROCK causes several biological events such as increase of neurite outgrowth, axonal regeneration, and activation of pro-survival Akt. Thus, it has attracted scientist's strong attentions and considered ROCK as a promising therapeutic target for treatment of neurodegenerative disorders including Alzheimer disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis...
April 1, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/26996632/behavioural-effects-of-basal-ganglia-rho-kinase-inhibition-in-the-unilateral-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#7
Salim Yalcin Inan, Burak Cem Soner, Ayse Saide Sahin
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects more than six million people in the world. While current available pharmacological therapies for PD in the early stages of the disease usually improve motor symptoms, they cause side effects, such as fluctuations and dyskinesias in the later stages. In this later stage, high frequency deep brain stimulation of the subthalamic nucleus (STN-DBS) is a treatment option which is most successful to treat drug resistant advanced PD...
August 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/26683082/fasudil-a-rho-kinase-inhibitor-promotes-the-autophagic-degradation-of-a53t-%C3%AE-synuclein-by-activating-the-jnk-1-bcl-2-beclin-1-pathway
#8
Feng-Tao Liu, Yu-Jie Yang, Jian-Jun Wu, Shan Li, Yi-Lin Tang, Jue Zhao, Zhen-Yang Liu, Bao-Guo Xiao, Ji Zuo, Wen Liu, Jian Wang
Accumulation of α-synuclein (α-syn) is pivotally implicated in the pathogenesis of Parkinson׳s disease (PD), and enhancing its clearance might be a promising strategy in PD treatment. It has recently been shown that Rho kinase (ROCK) activation is involved in many neurodegenerative diseases, and some ROCK inhibitors might promote the degradation of abnormal protein aggregates. However, it is not known if fasudil, the only ROCK inhibitor available in clinical setting, could promote the degradation of α-syn, and ameliorate the α-syn induced neurotoxicity...
February 1, 2016: Brain Research
https://www.readbyqxmd.com/read/26526034/csf-nrf2-and-hspa8-in-parkinson-s-disease-patients-with-and-without-lrrk2-gene-mutations
#9
David A Loeffler, Lynnae M Smith, Mary P Coffey, Jan O Aasly, Peter A LeWitt
Leucine-rich repeat kinase 2 (LRRK2) gene mutations are the most common genetic cause of Parkinson's disease (PD). CSF specimens from LRRK2 + PD patients and healthy LRRK2 mutation carriers are, therefore, useful for biomarker studies. This study examined the hypothesis that differences are present between subjects with sporadic PD (sPD), PD carriers of LRRK2 mutations (LRRK2 + PD), healthy control subjects lacking LRRK2 mutations (CTL), and LRRK2 mutation-carrying healthy controls (LRRK2 + CTL) for CSF concentrations of six potential PD biomarkers...
March 2016: Journal of Neural Transmission
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