Tetsushi Kataura, Etsu Tashiro, Shota Nishikawa, Kensuke Shibahara, Yoshihito Muraoka, Masahiro Miura, Shun Sakai, Naohiro Katoh, Misato Totsuka, Masafumi Onodera, Kazuo Shin-Ya, Kengo Miyamoto, Yukiko Sasazawa, Nobutaka Hattori, Shinji Saiki, Masaya Imoto
Macroautophagy/autophagy plays a critical role in the pathogenesis of various human diseases including neurodegenerative disorders such as Parkinson disease (PD) and Huntington disease (HD). Chemical autophagy inducers are expected to serve as disease-modifying agents by eliminating cytotoxic/damaged proteins. Although many autophagy inducers have been identified, their precise molecular mechanisms are not fully understood because of the complicated crosstalk among signaling pathways. To address this issue, we performed several chemical genomic analyses enabling us to comprehend the dominancy among the autophagy-associated pathways followed by an aggresome-clearance assay...
August 2021: Autophagy