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centella asiatica

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https://www.readbyqxmd.com/read/28905277/on-site-phytoremediation-applicability-assessment-in-alur-ilmu-universiti-kebangsaan-malaysia-based-on-spatial-and-pollution-removal-analyses
#1
Mohd Hafiyyan Mahmud, Khai Ern Lee, Thian Lai Goh
The present paper aims to assess the phytoremediation performance based on pollution removal efficiency of the highly polluted region of Alur Ilmu urban river for its applicability of on-site treatment. Thirteen stations along Alur Ilmu were selected to produce thematic maps through spatial distribution analysis based on six water quality parameters of Malaysia's Water Quality Index (WQI) for dry and raining seasons. The maps generated were used to identify the highly polluted region for phytoremediation applicability assessment...
September 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28883904/centella-asiatica-attenuates-mitochondrial-dysfunction-and-oxidative-stress-in-a%C3%AE-exposed-hippocampal-neurons
#2
Nora E Gray, Jonathan A Zweig, Donald G Matthews, Maya Caruso, Joseph F Quinn, Amala Soumyanath
Centella asiatica has been used for centuries to enhance memory. We have previously shown that a water extract of Centella asiatica (CAW) protects against the deleterious effects of amyloid-β (Aβ) in neuroblastoma cells and attenuates Aβ-induced cognitive deficits in mice. Yet, the neuroprotective mechanism of CAW has yet to be thoroughly explored in neurons from these animals. This study investigates the effects of CAW on neuronal metabolism and oxidative stress in isolated Aβ-expressing neurons. Hippocampal neurons from amyloid precursor protein overexpressing Tg2576 mice and wild-type (WT) littermates were treated with CAW...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28881630/protective-effect-of-madecassoside-on-h2o2-induced-oxidative-stress-and-autophagy-activation-in-human-melanocytes
#3
Yuting Ling, Qingli Gong, Xixi Xiong, Li Sun, Wene Zhao, Wenyuan Zhu, Yan Lu
BACKGROUND: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Some traditional Chinese Medicine doctors have found that it has therapeutic effects for external use in the repigmentation of vitiligo and post-inflammatory hypopigmentation. This study was designed to evaluate the effects of madecassoside, a major bioactive component of C. asiatica, on oxidative stress in human melanocytes and its possible mechanism of action...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878245/effects-of-centella-asiatica-l-urb-on-cognitive-function-and-mood-related-outcomes-a-systematic-review-and-meta-analysis
#4
Panupong Puttarak, Piyameth Dilokthornsakul, Surasak Saokaew, Teerapon Dhippayom, Chuenjid Kongkaew, Rosarin Sruamsiri, Anchalee Chuthaputti, Nathorn Chaiyakunapruk
Centella asiatica (L.) Urb. has been used as an herbal brain tonic for mental disorders and enhancing memory, but no review of the overall evidence of C. asiatica and cognitive function has been conducted. This study aims to determine the effects of C. asiatica on cognitive function and its related properties. The current systematic review includes five randomized controlled trials (RCTs) conducted to determine the effect of C. asiatica alone and six RCTs conducted to determine the effect of C. asiatica-containing products...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28861174/protective-effect-of-asiatic-acid-in-an-experimental-cerulein-induced-model-of-acute-pancreatitis-in-mice
#5
Wenqin Xiao, Weiliang Jiang, Kai Li, Yangyang Hu, Sisi Li, Li Zhou, Rong Wan
Asiatic acid (AA), a triterpenoid derived from the medicinal plant Centella asiatica, is considered to have anti-inflammatory, anti-fibrotic and anti-tumor effects, but its effects in acute pancreatitis (AP) are unknown. Our purpose of this study was to investigate the effects of AA in a mouse model of cerulein-induced pancreatitis. We evaluated AA in an experimental model of AP induced in mice by six hourly intraperitoneal injections of cerulein 50 µg/kg. Mice were pretreated with vehicle or AA 50 mg/kg 2 h before the first cerulein injection...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28860834/the-24-hour-skin-hydration-and-barrier-function-effects-of-a-hyaluronic-1-glycerin-5-and-centella-asiatica-stem-cells-extract-moisturizing-fluid-an-intra-subject-randomized-assessor-blinded-study
#6
Massimo Milani, Adele Sparavigna
INTRODUCTION: Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration. Centella asiatica extract (CAE) could exert lenitive, anti-inflammatory and reepithelialization actions...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28856520/asiatic-acid-ameliorates-doxorubicin-induced-cardiac-and-hepato-renal-toxicities-with-nrf2-transcriptional-factor-activation-in-rats
#7
Sarika M Kamble, Chandragouda R Patil
Asiatic acid (AA), a pentacyclic triterpenoid, is a key phytoconstituent of Centella asiatica. AA is a patented as a cytotoxic substance, and it exerts cytotoxicity against Hep3B, Hela and MCF-7 cell lines. However, pentacyclic triterpenoids also modulate the expression and transcriptional activities of Nrf2 and exert cytoprotective effects. In this study, we investigated the effects of AA on the doxorubicin (DXR)-induced organ toxicities and expression of the Nrf2. DXR toxicity was induced by a single intravenous injection of 65...
August 30, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28764778/centella-asiatica-modulates-cancer-cachexia-associated-inflammatory-cytokines-and-cell-death-in-leukaemic-thp-1-cells-and-peripheral-blood-mononuclear-cells-pbmc-s
#8
Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon, Alisa Phulukdaree, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy, Vikash Sewram
BACKGROUND: Cancer cachexia is associated with increased pro-inflammatory cytokine levels. Centella asiatica (C. asiatica) possesses antioxidant, anti-inflammatory and anti-tumour potential. We investigated the modulation of antioxidants, cytokines and cell death by C. asiatica ethanolic leaf extract (CLE) in leukaemic THP-1 cells and normal peripheral blood mononuclear cells (PBMC's). METHODS: Cytotoxcity of CLE was determined at 24 and 72 h (h). Oxidant scavenging activity of CLE was evaluated using the 2, 2-diphenyl-1 picrylhydrazyl (DPPH) assay...
August 1, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28738247/asiatic-acid-inhibits-lps-induced-inflammatory-response-in-human-gingival-fibroblasts
#9
Chunbo Hao, Buling Wu, Zhiming Hou, Qi Xie, Tianan Liao, Tao Wang, Dandan Ma
Asiatic acid, a triterpenoid component isolated from Centella asiatica (L.) Urban, possesses antioxidative and anti-inflammatory activities. In this study, we aimed to investigate the anti-inflammatory effects of asiatic acid both in vivo and in vitro. HGFs or RAW264.7 cells were treated with asiatic acid 1h before LPS treatment. Cell viability was measured by MTT assay. The levels of PGE2, NO, IL-6, and IL-8 were detected by ELISA. Protein expression levels were detected by western blot analysis. In vivo, asiatic acid significantly inhibited LPS-induced IL-6 and IL-8 expression levels in gingival tissues...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28733880/effect-of-asiatic-acid-on-the-ang-ii-at1r-nadph-oxidase-nf-%C3%AE%C2%BAb-pathway-in-renovascular-hypertensive-rats
#10
Putcharawipa Maneesai, Sarawoot Bunbupha, Upa Kukongviriyapan, Laddawan Senggunprai, Veerapol Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote
Asiatic acid, a triterpenoid compound derived from Centella asiatica, has been demonstrated to have antioxidant and anti-inflammatory effects. The present study evaluated the effects of asiatic acid on hemodynamic alterations, renin-angiotensin system (RAS), oxidative stress, and inflammation in 2K-1C hypertensive rats. Renovascular hypertension was induced in male Sprague-Dawley rats and treated with vehicle, asiatic acid (30 mg/kg/day), or captopril (5 mg/kg/day) for 4 weeks. We observed that 2K-1C hypertensive rats exhibited hemodynamic alterations such as high blood pressure, heart rate, hindlimb vascular resistance, and low hindlimb blood flow...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28716424/molecular-cloning-of-an-ester-forming-triterpenoid-udp-glucose-28-o-glucosyltransferase-involved-in-saponin-biosynthesis-from-the-medicinal-plant-centella-asiatica
#11
Fernanda de Costa, Carla J S Barber, Yeon-Bok Kim, Darwin W Reed, Haixia Zhang, Arthur G Fett-Neto, Patrick S Covello
Triterpene saponins include bioactive compounds with structures consisting of triterpene aglycones (sapogenins) and one or more sugar moieties linked through acetal or ester glycosidic linkages at one or more sites. Centella asiatica (L.) Urban is a medicinal plant that contains bioactive ursane-type saponins, such as madecassoside and asiaticoside. In this work, glucosylation of triterpenoids in C. asiatica was investigated starting with plant extracts. An enzyme capable of glucosylating asiatic and madecassic acids was partially purified...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28700628/asiatic-acid-protects-against-cognitive-deficits-and-reductions-in-cell-proliferation-and-survival-in-the-rat-hippocampus-caused-by-5-fluorouracil-chemotherapy
#12
Pornthip Chaisawang, Apiwat Sirichoat, Wunnee Chaijaroonkhanarak, Wanassanun Pannangrong, Bungorn Sripanidkulchai, Peter Wigmore, Jariya Umka Welbat
The chemotherapy drug, 5-fluorouracil (5-FU), has been reported to cause cognitive impairments in cancer patients. The drug also reduces cell proliferation and survival in the brain. Asiatic acid (AA) is a triterpene compound found in Centella asiatica that can protect against reduction of neurogenesis in the hippocampus and memory deficits induced by valproic acid (VPA). In the present study, we investigated the preventive effects of AA on the deficits in spatial working memory and cell proliferation and survival caused by 5-FU chemotherapy in a rat model...
2017: PloS One
https://www.readbyqxmd.com/read/28651288/development-of-a-high-performance-liquid-chromatographic-method-for-asiaticoside-quantification-in-different-skin-layers-after-topical-application-of-a-centella-asiatica-extract
#13
Priscila Bianca Rodrigues da Rocha, Bruno Dos Santos Souza, Lígia Marquez Andrade, Ricardo Neves Marreto, Eliana Martins Lima, Stephânia Fleury Taveira
The topical application of Centella asiatica extract has been commonly used for many different purposes but especially for cosmetic use in the treatment of gynoid lipodystrophy. Asiaticoside, the most active component in this extract, is responsible for its therapeutic activities. However, little is known to date about asiaticoside skin penetration. Thus, an analytical method for asiaticoside quantification in different skin layers after the topical application of C. asiatica extract was developed and skin permeation studies were performed with the plant extract to apply the analytical method developed...
June 26, 2017: Planta Medica
https://www.readbyqxmd.com/read/28566935/variations-in-echogenicity-in-carotid-and-femoral-atherosclerotic-plaques-with-pycnogenol%C3%A2-%C3%A2-centella-asiatica-supplementation
#14
Gianni Belcaro, Umberto Cornelli
This registry study evaluated echogenicity of carotid-femoral plaques in asymptomatic subjects with increased oxidative stress and risk factors (mild hypertension, hypercholesterolemia). Supplementation with the combination Pycnogenol-CA (centella asiatica) on the echogenicity of plaques was assessed at 6 months (79 subjects). A standard management (SM) plan was used in all subjects (control of risk factors, lifestyle changes); 36 subjects used the supplements +SM; 43 SM only. The groups were comparable. High-resolution ultrasound evaluated echogenicity and plaque structure...
June 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28560300/striae-gravidarum-risk-factors-prevention-and-management
#15
REVIEW
B Farahnik, K Park, G Kroumpouzos, J Murase
BACKGROUND: Striae gravidarum (SG) are atrophic linear scars that represent one of the most common connective tissue changes during pregnancy. SG can cause emotional and psychological distress for many women. Research on risk factors, prevention, and management of SG has been often inconclusive. METHODS: We conducted a literature search using textbooks, PubMed, and Medline databases to assess research performed on the risk factors, prevention, and management of SG...
June 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28559707/formulation-and-evaluation-of-a-water-in-oil-cream-containing-herbal-active-ingredients-and-ferulic-acid
#16
Mirela Moldovan, Abir Lahmar, Cătălina Bogdan, Simona Părăuan, Ioan Tomuţă, Maria Crişan
BACKGROUND AND AIMS: The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream. METHODS: The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1 (F1) was prepared using glyceryl stearate and Ceteareth-25® as emulsifiers and Formulation 2 (F2) using glyceryl stearate and potassium cetyl phosphate, all other ingredients remaining the same...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28537890/protective-effect-of-madecassoside-on-h2o2-induced-oxidative-stress-and-autophagy-activation-in-human-melanocytes
#17
Yuting Ling, Qingli Gong, Xixi Xiong, Li Sun, Wene Zhao, Wenyuan Zhu, Yan Lu
BACKGROUND: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Some traditional Chinese Medicine doctors have found that it has therapeutic effects for external use in the repigmentation of vitiligo and post-inflammatory hypopigmentation. This study was designed to evaluate the effects of madecassoside, a major bioactive component of C. asiatica, on oxidative stress in human melanocytes and its possible mechanism of action...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28510600/complete-comparison-display-ccd-evaluation-of-ethanol-extracts-of-centella-asiatica-and-withania-somnifera-shows-that-they-can-non-synergistically-ameliorate-biochemical-and-behavioural-damages-in-mptp-induced-parkinson-s-model-of-mice
#18
Maheep Bhatnagar, Ishan Goel, Tathagato Roy, Sunil Dutt Shukla, Sukant Khurana
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera that have been explored in some recent studies. In agreement with the previous work on ethanol extracts of these two plants in mice model, we saw an improvement in oxidative stress profile as well as behavioral performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms in Balb/c mice...
2017: PloS One
https://www.readbyqxmd.com/read/28490089/molecular-structure-stability-and-cytotoxicity-of-natural-green-colorants-produced-from-centella-asiatica-l-leaves-treated-by-steaming-and-metal-complexations
#19
Luxsika Ngamwonglumlert, Sakamon Devahastin, Naphaporn Chiewchan
Stability of extracts from Centella asiatica L. leaves treated by steaming and metal-chlorophylls complexations against combined acid-heat was compared with that from untreated leaves and synthetic colorant. Formation of metal-chlorophylls complexes was confirmed by FTIR spectroscopy. Molecular structure changes during stability test and cytotoxicity of the extracts against Vero cells were evaluated. Utilization of the extracts as colorant was also assessed in selected beverage ingredient and food. Copper-chlorophylls extracts exhibited similar green hue to those from untreated and steamed leaves, while zinc-chlorophylls extracts exhibited yellow-green color...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28447512/centella-asiatica-enhances-hepatic-antioxidant-status-and-regulates-hepatic-inflammatory-cytokines-in-type-2-diabetic-rats
#20
Ayodeji B Oyenihi, Novel N Chegou, Oluwafemi O Oguntibeju, Bubuya Masola
CONTEXT: Neutralizing the over-activation of oxidative stress and inflammation remains an important goal in the management of type 2 diabetes mellitus (T2DM). Centella asiatica (L.) Urban (Apiaceae) (CA) has been used in traditional folklore in Africa and Asia to treat various ailments including diabetes. OBJECTIVE: We investigated the hepatic antioxidant and anti-inflammatory potential of methanol extract of CA leaves in T2DM. MATERIALS AND METHODS: T2DM was induced in male Sprague-Dawley rats with 10% fructose in drinking water for 14 days followed by a single intraperitoneal injection of streptozotocin (40 mg/kg b...
December 2017: Pharmaceutical Biology
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