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Tuberculosis imaging

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https://www.readbyqxmd.com/read/28912165/holistic-care-of-complicated-tuberculosis-in-healthcare-settings-with-limited-resources
#1
Trevor Duke, Sharon Kasa Tom, Harry Poka, Henry Welch
In recent years, most of the focus on improving the quality of paediatric care in low-income countries has been on improving primary care using the Integrated Management of Childhood Illness, and improving triage and emergency treatment in hospitals aimed at reducing deaths in the first 24 hours. There has been little attention paid to improving the quality of care for children with chronic or complex diseases. Children with complicated forms of tuberculosis (TB), including central nervous system and chronic pulmonary TB, provide examples of acute and chronic multisystem paediatric illnesses that commonly present to district-level and second-level referral hospitals in low-income countries...
September 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28904582/giant-intracerebral-tuberculoma-with-complete-disappearance-on-antitubercular-therapy-alone-in-a-pediatric-case-a-case-illustration-with-review-of-management-strategy
#2
Guru Dutta Satyarthee
The Central nervous system can be affected in extrapulmonary tuberculosis. The intracranial tuberculoma occurrence is a rare entity occurrence; most often occur in the form of discrete small multiple lesions. Rarely a large sized tuberculoma is observed with mass effects and usually managed surgically to provide rapid relief of mass effect, histopathological confirmation of diagnosis, reduction of pathological mass thereby increasing efficacy of medical therapy. Author reports an extremely rare case of giant tuberculoma occurring in a pediatric patient, which was managed with antituberculous medication along with cerebral decongestant...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28904183/the-tb-portals-an-open-access-web-based-platform-for-global-drug-resistant-tuberculosis-data-sharing-and-analysis
#3
Alex Rosenthal, Andrei Gabrielian, Eric Engle, Darrell E Hurt, Sofia Alexandru, Valeriu Crudu, Eugene Sergueev, Valery Kirichenko, Vladzimir Lapitskii, Eduard Snezhko, Vassili Kovalev, Andrei Astrovko, Alena Skrahina, Jessica Taaffe, Michael Harris, Alyssa Long, Kurt Wollenberg, Irada Akhundova, Sharafat Ismayilova, Aliaksandr Skrahin, Elcan Mammadbayov, Hagigat Gadirova, Rafik Abuzarov, Mehriban Seyfaddinova, Zaza Avaliani, Irina Strambu, Dragos Zaharia, Alexandru Muntean, Eugenia Ghita, Miron Bogdan, Roxana Mindru, Victor Spinu, Alexandra Sora, Catalina Ene, Sergo Vashakidze, Natalia Shubladze, Ucha Nanava, Alexander Tuzikov, Michael Tartakovsky
The TB Portals Program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and IT professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis and backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), of which 976 (75...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28900554/primary-epithelioid-angiosarcoma-of-lung-radiologic-and-clinicopathologic-correlation
#4
Fung Him Ng, San Ming Yu, Ophelia Ka Heng Wai, James Chi Sang Chan
Primary pulmonary angiosarcoma is extremely rare. It is often characterized by a clinically indolent course and delayed diagnosis. To date, there have been <20 cases reported. By far, little article correlates the clinical presentation, the imaging findings with the pathology. The authors present a case of middle-aged gentleman with primary pulmonary epithelioid angiosacroma which we initially thought as tuberculosis (TB) infection. A 60-year-old gentleman, with a history of 6 months on and off blood stained sputum, was admitted for an episode of massive hemoptysis...
2017: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/28898343/-differential-diagnosis-of-bone-marrow-and-lung-granulomas-report-of-one-case
#5
Camila Peña, Andrés Soto, Pablo Villegas
The differential diagnosis of pulmonary tuberculosis and lymphoma with pulmonary infiltration is very difficult, given their similar clinical characteristics. We report a 59 year old female with weight loss, fever, dyspnea and cough of several months of duration. She had a cavitated mass in lung imaging. A positive conventional PCR lead to the diagnosis of tuberculosis, but she had negative smears and cultures for Mycobacterium tuberculosis. The patient did not respond to treatment and her clinical condition worsened...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28889138/pulmonary-actinomycosis-masquerading-as-lung-cancer-a-case-report
#6
Y L Boo, K N How, D S Pereira, P W Chin, K K Foong, S Y Lim
Pulmonary actinomycosis is a rare yet important and challenging diagnosis to make. It is commonly confused with other lung diseases, such as tuberculosis and bronchogenic carcinoma, leading to delay diagnosis or misdiagnosis. A 49-year-old man presented with a chronic cough, hemoptysis, and pleuritic chest pain. His initial imaging studies including computed tomography (CT) was suggestive of bronchogenic carcinoma. A subsequent CTguided biopsy was consistent with pulmonary actinomycosis and excluded the possibility of bronchogenic carcinoma...
August 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28885539/a-comparison-of-18f-fdg-pet-mr-with-pet-ct-in-pulmonary-tuberculosis
#7
Benjamin A Thomas, James S Molton, Francesca Leek, Yan Pang, John J Totman, Nicholas I Paton, David W Townsend
PURPOSE: PET/computed tomography (CT) has been shown to detect lesions in patients with pulmonary tuberculosis (PTB) and may be useful for assessing PTB disease in clinical research studies. However, radiation dose is of concern for clinical research in individuals with an underlying curable disease. This study aimed to determine whether PET/MR is equivalent to PET/CT in PTB. MATERIALS AND METHODS: Ten patients with microbiologically confirmed PTB were recruited...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28885371/clinical-and-diagnostic-features-of-angiosarcoma-with-pulmonary-metastases-a-retrospective-observational-study
#8
Hanping Wang, Juhong Shi, Hongrui Liu, Yeye Chen, Yining Wang, Wenze Wang, Li Zhang
Angiosarcoma with pulmonary metastasis is a rare, fatal disease that often presents with multiple pulmonary nodules and diffuse alveolar hemorrhage. We herein review the detailed clinical characteristics of pulmonary metastatic angiosarcoma and determine a reasonable diagnostic strategy.The medical records of 11 patients with pulmonary angiosarcoma were reviewed.The mean age of the patients was 45.7 years (range, 30-71 years). All patients were male. The most common symptom was hemoptysis (8/11). Common initial misdiagnoses were tuberculosis (5/11), vasculitis (2/11), nontuberculous infectious disease (1/11), and constrictive pericarditis (1/11)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28869938/mineral-and-bone-disorder-in-chronic-kidney-disease-a-case-report-from-vietnam
#9
Pham Van Bui, Nguyyen Minh Tuan, Huynh Thi Nguyen Nghia, Pham Nguyen Thanh Phuong
We report a case of calcium pyrophosphate dihydrate deposition disease (CPDD) involving a patient on maintenance hemodialysis (MHD). The 32-year-old man presented in August 2016 with a complaint of left shoulder swelling of 8 months' duration with no trauma or fever. He was diagnosed with nephrotic syndrome in 1998, which progressed to ESRD. He commenced MHD in 2012. Examination at our hospital revealed a soft nontender swelling of the left shoulder. Blood biochemistry showed elevated serum urate, phosphate, β2 microglobulin, and parathyroid hormone...
2017: Blood Purification
https://www.readbyqxmd.com/read/28859520/the-downfall-of-tba-354-a-possible-explanation-for-its-neurotoxicity-via-mass-spectrometric-imaging
#10
Sphamandla Ntshangase, Adeola Shobo, Hendrik G Kruger, Arndt Asperger, Dagmar Niemeyer, Per I Arvidsson, Thavendran Govender, Sooraj Baijnath
TBA-354 was a promising antitubercular compound with activity against both replicating and static Mycobacterium tuberculosis (M.tb), making it the focal point of many clinical trials conducted by the TB Alliance. However, findings from these trials have shown that TBA-354 results in mild signs of reversible neurotoxicity; this left the TB Alliance with no other choice but to stop the research. In this study, mass spectrometric methods were used to evaluate the pharmacokinetics and spatial distribution of TBA-354 in the brain using a validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) and mass spectrometric imaging (MSI), respectively...
September 1, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28856141/diagnosis-and-treatment-of-pulmonary-cavity-after-liver-transplantation
#11
Yongxiang Xia, Haoming Zhou, Feipeng Zhu, Wei Zhang, Chen Wu, Ling Lu
BACKGROUND: Although the outcomes have improved in the current era, pulmonary infection remains a significant post-transplant complication in liver transplant (LT) recipients. Pulmonary infection with cavity formation often leads to higher mortality rates after LT. We wished to investigate the diagnosis and treatment of pulmonary cavity (PC) formation after LT. METHODS: We evaluated (retrospectively) five cases of PC formation, shown on CT scans of the chest after LT, by analyzing imaging features, diagnosis, treatment, liver function, and the concentration changes and efficacy of immunosuppressants...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28852644/asbestos-related-diseases-in-mineworkers-a-clinicopathological-study
#12
Ntombizodwa Ndlovu, David Rees, Jill Murray, Naseema Vorajee, Guy Richards, Jim teWaterNaude
The accurate diagnosis of asbestos-related diseases is important because of past and current asbestos exposures. This study evaluated the reliability of clinical diagnoses of asbestos-related diseases in former mineworkers using autopsies as the reference standard. Sensitivity, specificity, positive predictive value and negative predictive value were calculated. The 149 cases identified had clinical examinations 0.3-7.4 years before death. More asbestos-related diseases were diagnosed at autopsy rather than clinically: 77 versus 52 for asbestosis, 27 versus 14 for mesothelioma and 22 versus 3 for lung cancer...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28845112/safety-and-utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-focal-splenic-lesions-a-retrospective-analysis
#13
Surinder S Rana, Vishal Sharma, Ravi Sharma, Radhika Srinivasan, Rajesh Gupta
BACKGROUND: Fine-needle aspiration (FNA) of focal splenic lesions (FSL) is usually done under ultrasound (US) or computed tomography guidance. Endoscopic US (EUS), because of its ability to provide high-resolution images, can be used for aspirating FSL. We studied the safety and efficacy of EUS-guided FNA of FSL. METHODS: We performed a retrospective analysis of patients with FSL undergoing EUS-guided FNA over the last six years. RESULTS: EUS-guided FNA was performed in 16 patients (age: 28-43 years; male: 11)...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28843114/clinical-and-radiological-predictors-of-outcome-in-tubercular-meningitis-a-prospective-study-of-209-patients
#14
M Modi, K Sharma, S Prabhakar, M K Goyal, A Takkar, N Sharma, A Garg, S Faisal, N Khandelwal, P Singh, J Sachdeva, R Shree, V Rishi, V Lal
OBJECTIVES: The predictors of poor outcome in tuberculous meningitis (TBM) remain to be delineated. We determined role of various clinical, radiological and cerebrospinal fluid (CSF) parameters in prediction of outcome in TBM. PATIENTS AND METHODS: Current study was a prospective observational study including 209 patients of TBM. All patients underwent detailed evaluation including Gadolinium enhanced Magnetic resonance imaging (GdMRI) of brain as well as tests to detect evidence of tuberculosis elsewhere in body...
August 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28837117/preclinical-assessment-of-a-68-ga-dota-functionalized-depsipeptide-as-a-radiodiagnostic-infection-imaging-agent
#15
Thomas Ebenhan, Botshelo Brenda Mokaleng, Jacobus Daniel Venter, Hendrik Gert Kruger, Jan Rijn Zeevaart, Mike Sathekge
The study assessed a radiolabeled depsipeptide conjugate ((68)Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. (68)Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2) rabbits bearing muscular sterile inflammation and Staphylococcus aureus (SA) infection; and (NZR3) rabbits infected with Mycobacterium tuberculosis (MTB) combined with a subcutaneous scruff infection of SA in the same animal. All animals were imaged using a PET/CT scanner at 5 and 60 min post injection...
August 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28819600/extensively-drug-resistant-tuberculosis-of-the-lumbar-spine-in-a-six-year-old-child-a-case-report
#16
Siddharth Sanjay Shah, Aakanksha Arvind Goregaonkar, Arvind Balkrishna Goregaonkar
INTRODUCTION: The emergence of extensively drug-resistant tuberculosis (XDR-TB) is a challenging paradigm shift faced by the TB control programs worldwide today. The treatment is further compounded with unique management difficulties faced in pediatric patients. Treatment of XDR-TB requires prolonged chemotherapy with second-line drugs which offer lesser potency and increased risk of drug-related side effects. We present a case of spinal XDR-TB in a child, managed with extended second-line antitubercular chemotherapy (ATT)...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28814938/superior-mesenteric-artery-syndrome-in-association-with-abdominal-tuberculosis-an-eye-opener
#17
Shuchi Bhatt, Biswajit Mishra, Anupama Tandon, Smita Manchanda, G Parthsarathy
Superior Mesenteric Artery Syndrome (SMAS) is a rare clinical entity presenting as acute or chronic upper gastrointestinal obstruction. It occurs due to compression of third part of duodenum between abdominal aorta and overlying superior mesenteric artery caused by a decrease in angle between the two vessels. Rapid loss of retroperitoneal fat, in conditions leading to severe weight loss is the main factor responsible for this disorder. Superior mesenteric artery syndrome in association with abdominal tuberculosis has not been reported earlier to the best of our knowledge...
May 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28806025/brain-tuberculoma-a-case-report-and-literature-review
#18
Khalil Aloreidi, Jamal Dodin, Jeremy Berg, Wendell Hoffman
We are reporting on a rare case of central nervous system tuberculosis (TB) in the state of South Dakota. Our case features one of the most infrequent forms of TB in the brain: multiple tuberculomas. A 44-year-old immunocompetent man was admitted complaining of a headache and fever for a week. His physical exam was unremarkable. A magnetic resonance imaging scan of his brain showed two ring-enhancing lesions. The largest lesion was excised surgically and the histopathology exam was consistent with tuberculoma...
July 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28804639/tuberculosis-joint-infections-in-four-domestic-cats
#19
Stephanie M Lalor, Stephen Clarke, Jonathan Pink, Andrew Parry, Emma Scurrell, Noel Fitzpatrick, Fraje Watson, Conor O'Halloran, Danielle Gunn-Moore
CASE SERIES SUMMARY: This paper describes the clinical presentation, diagnostic imaging findings and outcome in four cats with confirmed joint-associated tuberculosis. The cats were 2-6 years of age, and immune competent. Three cases had tuberculosis affecting only one joint, whereas one case had at least three joints affected. Two cases were caused by Mycobacterium bovis, and the other two were caused by Mycobacterium microti. Radiological findings included osteolysis, periosteal reaction and associated soft tissue swelling...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/28800442/pre-trained-convolutional-neural-networks-as-feature-extractors-for-tuberculosis-detection
#20
U K Lopes, J F Valiati
It is estimated that in 2015, approximately 1.8 million people infected by tuberculosis died, most of them in developing countries. Many of those deaths could have been prevented if the disease had been detected at an earlier stage, but the most advanced diagnosis methods are still cost prohibitive for mass adoption. One of the most popular tuberculosis diagnosis methods is the analysis of frontal thoracic radiographs; however, the impact of this method is diminished by the need for individual analysis of each radiography by properly trained radiologists...
August 4, 2017: Computers in Biology and Medicine
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