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Multiple sclerosis neuropsychiatry

E Drouin, T Péréon, Y Péréon
The name of the French neurologist and psychiatrist Jean Lhermitte (1877-1959) is most often associated with the sign he described back in 1927 in three patients with multiple sclerosis. We are reporting unpublished handwritten notes by Jean Lhermitte about 'demonic possession', which date from the 1950s. Drawing from his experiences in neuropsychiatry, Lhermitte gathered notable case reviews as well as individual case histories. For him, cases of demonic possession are of a psychiatric nature with social background exerting a strong influence...
April 21, 2017: L'Encéphale
Brittany Litster, Kirsten M Fiest, Scott B Patten, John D Fisk, John R Walker, Lesley A Graff, James M Bolton, Jitender Sareen, James J Marriott, Lindsay I Berrigan, Charles N Bernstein, Ryan Zarychanski, Alexander Singer, Carol A Hitchon, Christine A Peschken, Ruth Ann Marrie
Background: Anxiety is prevalent in people with multiple sclerosis (MS). Screening measures are used to identify symptoms of anxiety, but the optimal measure to screen for anxiety disorders in MS has not been established. Methods: We searched the MEDLINE, Embase, PsycINFO, PsycARTICLES Full Text, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Scopus databases from database inception until August 7, 2015. Two independent reviewers screened abstracts and full-text reports for study inclusion, extracted data, and assessed risk of bias...
November 2016: International Journal of MS Care
Emma Banwell, Bennis Pavisian, Liesly Lee, Anthony Feinstein
BACKGROUND: Canada has the highest incidence of MS worldwide. Anecdotal evidence reveals that people with MS smoke, ingest or vaporize cannabis for a multiplicity of reasons. With the legal situation in relation to use currently in flux, we undertook a study investigating patterns of use amongst people with MS and their attitudes towards the drug. METHODS: A consecutive sample of people with MS (n=246) attending a neurology (n=118) and a neuropsychiatry (n=107) clinic was enrolled and asked to complete a questionnaire containing demographic, disease and cannabis related variables...
November 2016: Multiple Sclerosis and related Disorders
John M Petitto, Zhi Huang, Danielle Meola, Grace K Ha, Daniel Dauer
The effects of IL-2 on brain development, function, and disease are the result of IL-2's actions in the peripheral immune system and its intrinsic actions in the central nervous system (CNS). Determining whether, and under what circumstances (e.g., development, acute injury), these different actions of IL-2 are operative in the brain is essential to make significant advances in understanding the multifaceted affects of IL-2 on CNS function and disease, including psychiatric disorders. For several decades, there has been a great deal of speculation about the role of autoimmunity in brain disease...
2012: Methods in Molecular Biology
Dorothy G Flood, Gerard J Marek, Michael Williams
The need to develop effective treatments for Alzheimer's disease has been confounded by repeated clinical failures where promising new chemical entities that have been extensively characterized in preclinical models of Alzheimer's disease have failed to show efficacy in the human disease state. This has been attributed to: the selection of drug targets that have yet to be shown as causal to the disease as distinct from being the result of the disease process, a lack of congruence in the animal models of Alzheimer's disease, wild-type and transgenic, to the human disease, and the enrollment of patients in proof of concept clinical trials who are at too advanced a stage of the disease to respond to any therapeutic...
June 15, 2011: Biochemical Pharmacology
Thomas Paparrigopoulos, Panagiotis Ferentinos, Anastasios Kouzoupis, George Koutsis, George N Papadimitriou
Neuropsychiatric symptoms are common in multiple sclerosis (MS). They include two broad categories of disturbances: abnormalities in cognition, and abnormalities of mood, affect and behaviour. The present review deals with the epidemiology, clinical features, etiology and treatment of disturbances included in the second category, i.e., major depression, fatigue and sleep disorders, bipolar disorder, euphoria, pathological laughing and crying, anxiety, psychosis and personality changes. Major depression is one of the most common neuropsychiatric disorders in MS with an approximate 50% lifetime prevalence rate...
2010: International Review of Psychiatry
Juraj Sepcić, Eduard Pavlović, Olivio Perković, Ante Skrobonja
There are three distinct phases in the life of Zvonimir Susić--neurologist, psychiatrist, forensic expert, educator, teacher, translator, and erudite of general and professional knowledge--Zagreb, Rijeka and Zadar phase. In Zagreb (1926-1946) he was promoted to physician (1932), there he was a student tutor, then the assistant at the Physiology Institute of the Medical Faculty; volunteer, hospital doctor (he got the specialization in 1938), assistant and head doctor of the Hospital for Mental Diseases in Vrapce, and the assistant professor (1941) at the Neuropsychiatric Department of the Zagreb University...
September 2008: Lijec̆nic̆ki Vjesnik
A Gronchi-Perrin, J-M Annoni, A Berney, S Simioni, F J G Vingerhoets
The assessement of behavior is common part of the neurological examination. This article reviews the behavioral and mood manifestations in four classical syndroms: Epilepsy, stroke, Parkinson's disease and multiple sclerosis.
May 7, 2008: Revue Médicale Suisse
Constantin G Lyketsos, Nicholas Kozauer, Peter V Rabins
Neuropsychiatry represents a field of medicine situated at the crossroads of neurology and psychiatry, and deals with the interface of behavioral phenomena driven by brain dysfunction. Psychiatric symptoms are highly prevalent in these conditions, are a major source of disability and diminished quality of life, and potentially represent the target of treatment interventions that stand to significantly decrease the suffering they generate. In this article, the disease paradigm is explained, with particular attention to its role as an organizing principle for the field...
2007: Dialogues in Clinical Neuroscience
Omar Ghaffar, Anthony Feinstein
PURPOSE OF REVIEW: The aim of this review is to summarize the current literature on the neuropsychiatry of multiple sclerosis (MS). RECENT FINDINGS: Data from community samples have supported earlier findings from tertiary referral centres of high rates of depression in MS patients. Neuroimaging offers important clues as to the pathogenesis of depression, but psychosocial factors cannot be ignored and emerge as equally important predictors. Cognitive-behavioural therapy is an effective treatment, rivalling standard dosing of sertraline in patients with depression...
May 2007: Current Opinion in Psychiatry
Anthony Feinstein
No abstract text is available yet for this article.
May 2005: CNS Spectrums
M Gadea-Doménech, R Espert-Tortajada
AIM: To review the most recent data regarding clinical applications of the dichotic listening technique in neurology and neuropsychiatry. DEVELOPMENT: The technique is described, in addition to the two main cognitive abilities we can measure with it. First, language lateralization, following Kimura's model as an anatomical explanation of the right ear advantage effect. Second, the attentional function, including Kinsbourne's model and the forced attention paradigm from Hugdahl as a valuable working tool to evaluate selective attention and executive functions...
July 1, 2004: Revista de Neurologia
Anthony Feinstein
This review describes the many neuropsychiatric abnormalities associated with multiple sclerosis (MS). These may be broadly divided into 2 categories: disorders of mood, affect, and behaviour and abnormalities affecting cognition. With respect to the former, the epidemiology, phenomenology, and theories of etiology are described for the syndromes of depression, bipolar disorder, euphoria, pathological laughing and crying, and psychosis attributable to MS. The section discussing cognition reviews the prevalence and nature of cognitive dysfunction, with an emphasis on abnormalities affecting multiple domains of memory, speed of information processing, and executive function...
March 2004: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
No abstract text is available yet for this article.
November 21, 1963: La Revue du Praticien
D B Arciniegas, J Topkoff
The ability to skillfully regulate the internal experience and outward expression of emotion is among the most complex and recently acquired functions of the human brain. When the capacity for emotional regulation is compromised by disease or injury the impact on individuals and their families may be considerable, both with regard to psychological well-being and social and occupational function. This article describes first a framework for the description, evaluation, and treatment of affective dysregulation...
October 2000: Seminars in Clinical Neuropsychiatry
G Salemi, P Ragonese, P Aridon, A Reggio, A Nicoletti, D Buffa, S Conte, G Savettieri
OBJECTIVE: To compare the monthly distribution of multiple sclerosis (MS) patients' births with that of the Sicilian population. BACKGROUND: Studies on the association between season of birth and risk of MS are scanty and controversial. DESIGN AND METHODS: Archives of the Institute of Neuropsychiatry of the Universities of Palermo and Catania were searched up to 1995 for definite MS patients (McDonald & Halliday criteria). The monthly distribution of MS patients' births (N= 965) was compared with that of the Sicilian population (N= 5,608,307)...
June 2000: Acta Neurologica Scandinavica
T Bottiglieri
Folate and vitamin B12 are required both in the methylation of homocysteine to methionine and in the synthesis of S-adenosylmethionine. S-adenosylmethionine is involved in numerous methylation reactions involving proteins, phospholipids, DNA, and neurotransmitter metabolism. Both folate and vitamin B12 deficiency may cause similar neurologic and psychiatric disturbances including depression, dementia, and a demyelinating myelopathy. A current theory proposes that a defect in methylation processes is central to the biochemical basis of the neuropsychiatry of these vitamin deficiencies...
December 1996: Nutrition Reviews
M F Mendez
OBJECTIVE: This article examines the cognitive and psychiatric features of multiple sclerosis. MS can manifest as a neuropsychiatric disturbance even in the absence of physical disabilities. METHOD: Two MS patients with predominant behavioral symptoms are described, and the literature is reviewed. RESULTS: The first patient had an interhemispheric disconnection syndrome, and the second patient had cognitive fatigue and depression. Other patients have slowed information processing speed, memory retrieval difficulty, frontal-executive dysfunction, and visuospatial difficulty...
1995: International Journal of Psychiatry in Medicine
J Lereboullet, A Rosa, R Olivier-Martin
No abstract text is available yet for this article.
March 11, 1974: La Revue du Praticien
H Diessner
No abstract text is available yet for this article.
October 1969: Psychiatrie, Neurologie, und Medizinische Psychologie
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