keyword
https://read.qxmd.com/read/38556399/ageing-related-considerations-for-medication-used-in-supportive-care-in-cancer
#21
REVIEW
Darren J Walsh, Michelle O'Driscoll, Laura J Sahm, Anne Marie Meagher, Pedro Doblas, Eimear McGowan, Gráinne Smith-Lehane, Michelle Hannan, Caitríona Goggin, Carol Buckley, Anne M Horgan
Both randomized controlled trials (RCTs) and retrospective studies have shown that a comprehensive geriatric assessment (CGA) prior to a patient commencing systemic anti-cancer therapy (SACT) results in improved quality of life outcomes and is associated with a decreased risk of grade 3-5 toxicity; however, data are lacking in relation to adverse drug events (ADE) associated with supportive care medications. Supportive care medications are prescribed as prophylactic agents in a SACT regimen, for management of treatment related toxicity and for symptoms caused by the disease itself...
March 30, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38551689/polypharmacy-drug-drug-interactions-anticholinergic-burden-and-cognitive-outcomes-a-snapshot-from-a-community-dwelling-sample-of-older-men-and-women-in-northern-italy
#22
JOURNAL ARTICLE
Elena Perdixi, Matteo Cotta Ramusino, Alfredo Costa, Sara Bernini, Silvia Conti, Nithiya Jesuthasan, Marco Severgnini, Federica Prinelli
Polypharmacy (PP) use is very common in older people and may lead to drug-drug interactions (DDIs) and anticholinergic burden (ACB) that may affect cognitive function. We aimed to determine the occurrence of PP, potential DDIs and ACB and their role in cognitive outcomes in an older population. Cross-sectional data from 636 community-dwelling adults (73.2 ± 6.0 SD, 58.6% women) participating in the NutBrain study (2019-2023) were analyzed. Participants were asked about their medication use, and data on potential DDIs and ACB were extracted...
March 29, 2024: European Journal of Ageing
https://read.qxmd.com/read/38538448/pharmaceutical-recommendations-for-therapeutic-appropriateness-in-multiple-sclerosis-patients
#23
JOURNAL ARTICLE
María Del Mar Sánchez Suárez, Alicia Martín Roldán, Maria Rosa Cantudo Cuenca, Alberto Jiménez Morales
OBJECTIVE: To determine the prevalence of PIMDINAC criteria and to implement pharmacological interventions in a population with multiple sclerosis over 55 years of age. METHODS: Retrospective observational open-label study including patients with multiple sclerosis aged 55 years and older between December 2022 and February 2023. The main variable determined was the percentage of compliance with the PIMDINAC criteria. RESULTS: Ninety-five patients were included, with the presence of PIMDINAC criteria detected in 67...
March 26, 2024: Farmacia Hospitalaria
https://read.qxmd.com/read/38536102/resin-immobilized-palladium-acetate-and-alcohol-dehydrogenase-for-chemoenzymatic-enantioselective-synthesis-of-chiral-diarylmethanols
#24
JOURNAL ARTICLE
Yanyan Li, Guanhua Liu, Liya Zhou, Li Ma, Ying He, Jing Gao, Yanjun Jiang, Limei Ren, Yunting Liu
The enantioselective synthesis of chiral diarylmethanols is highly desirable in synthetic chemistry and the pharmaceutical industry, but it remains challenging, especially in terms of green and sustainable production. Herein, a resin-immobilized palladium acetate catalyst was fabricated with high activity, stability, and reusability in Suzuki cross-coupling reaction of acyl halides with boronic acids, and the coimmobilization of alcohol dehydrogenase and glucose dehydrogenase on resin supports was also conducted for asymmetric bioreduction of diaryl ketones...
March 27, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38532786/weak-base-drug-induced-endolysosome-iron-dyshomeostasis-controls-the-generation-of-reactive-oxygen-species-mitochondrial-depolarization-and-cytotoxicity
#25
JOURNAL ARTICLE
Peter W Halcrow, Darius N K Quansah, Nirmal Kumar, Rebecca L Solloway, Kayla M Teigen, Kasumi A Lee, Braelyn Liang, Jonathan D Geiger
OBJECTIVES: Approximately 75 % of marketed drugs have the physicochemical property of being weak bases. Weak-base drugs with relatively high pKa values enter acidic organelles including endosomes and lysosomes (endolysosomes), reside in and de-acidify endolysosomes, and induce cytotoxicity. Divalent cations within endolysosomes, including iron, are released upon endolysosome de-acidification. Endolysosomes are "master regulators of iron homeostasis", and neurodegeneration is linked to ferrous iron (Fe2+ )-induced reactive oxygen species (ROS) generation via Fenton chemistry...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38525745/deprescribing-in-older-poly-treated-patients-affected-with-dementia
#26
JOURNAL ARTICLE
Pietro Gareri, Luca Gallelli, Ilaria Gareri, Vincenzo Rania, Caterina Palleria, Giovambattista De Sarro
Polypharmacy is an important issue in older patients affected by dementia because they are very vulnerable to the side effects of drugs'. Between October 2021 and September 2022, we randomly assessed 205 old-aged outpatients. The study was carried out in a Center for Dementia in collaboration with a university center. The primary outcomes were: (1) deprescribing inappropriate drugs through the Beers and STOPP&START criteria; (2) assessing duplicate drugs and the risk of iatrogenic damage due to drug-drug and drug-disease interactions...
February 26, 2024: Geriatrics
https://read.qxmd.com/read/38523839/predictors-of-postoperative-delirium-in-paediatric-patients-undergoing-surgery-under-general-anaesthesia-at-amhara-regional-state-tertiary-hospitals-a-multicenter-prospective-study
#27
JOURNAL ARTICLE
Debas Yaregal Melesse, Tadesse Teshale Tesema, Zemenay Ayinie Mekonnen, Wubie Birlie Chekol, Biruk Adie Admass, Misganaw Mengie Workie
INTRODUCTION: Postoperative delirium in paediatric patients is a recognised issue. Nevertheless, in low- and middle-income nations, researchers have had luck in determining its extent and predictors. Identifying predictors of postoperative delirium in paediatric patients having general anaesthesia at Tertiary Hospitals in Ethiopia was the aim of this study. METHODS: A multicenter, prospective follow up study was conducted from April 15 to June 15, 2023 at the study settings...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38523048/comparison-of-maximum-voided-volume-and-maximum-bladder-capacity-in-voiding-diary-uroflowmetry-and-cystometrography-in-children-with-non-neurogenic-lower-urinary-tract-dysfunction
#28
JOURNAL ARTICLE
Cagri Akin Sekerci, Yiloren Tanidir, Gunal Ozgur, Raziye Ergun, Mehmet Cetin, Tufan Tarcan, Selcuk Yucel
BACKGROUND: Maximum voided volumes (MVV) and maximum bladder capacities (MBC) are important parameters in the evaluation of lower urinary tract functions in children. However, consistency of MVV and MBC measurements between voiding diary (VD), uroflowmetry (UF) and cystometrography (CMG) in children with non-neurogenic lower urinary tract dysfunction (LUTD) has not been addressed specifically. OBJECTIVE: We aimed to compare the MVV in VD and UF and MBC in CMG in children with non-neurogenic LUT dysfunction and investigate for possible factors for discrepancies...
March 15, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38522709/a-novel-bhlh-gene-responsive-to-low-nitrogen-positively-regulates-the-biosynthesis-of-medicinal-tropane-alkaloids-in-atropa-belladonna
#29
JOURNAL ARTICLE
Yuqin Gou, Yanming Jing, Jiaxin Song, Mohammad Mahmoud Nagdy, Chao Peng, Lingjiang Zeng, Min Chen, Xiaozhong Lan, Zun Lai Lai Htun, Zhihua Liao, Yan Li
Medicinal tropane alkaloids (TAs), including hyoscyamine, anisodamine and scopolamine, are essential anticholinergic drugs specifically produced in several solanaceous plants. Atropa belladonna is one of the most important medicinal plants that produces TAs. Therefore, it is necessary to cultivate new A. belladonna germplasm with the high content of TAs. Here, we found that the levels of TAs were elevated under low nitrogen (LN) condition, and identified a LN-responsive bHLH transcription factor (TF) of A. belladonna (named LNIR) regulating the biosynthesis of TAs...
March 23, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38520502/real-world-adherence-to-and-persistence-with-vibegron-in-patients-with-overactive-bladder-a-retrospective-claims-analysis
#30
JOURNAL ARTICLE
Benjamin Chastek, Adam Carrera, Christina Landis, Daniel Snyder, Laleh Abedinzadeh, Tim Bancroft, Jeffrey Nesheim, Michael Kennelly, David Staskin
INTRODUCTION: Vibegron is a β3 -adrenergic receptor agonist approved for overactive bladder (OAB). This analysis assessed real-world adherence and persistence with vibegron in patients with OAB, along with demographics and clinical characteristics associated with adherence and persistence. METHODS: This retrospective study used the Optum Research Database to identify patients treated with vibegron from April 2021 to August 2022 (identification period). Patients had ≥ 60 days of continuous pharmacy coverage in a commercial or Medicare Advantage plan following the index fill (follow-up)...
March 23, 2024: Advances in Therapy
https://read.qxmd.com/read/38505157/the-role-of-botulinum-toxin-in-the-management-of-nonneurogenic-overactive-bladder-in-children-highlights-for-clinical-practice-a-systematic-review
#31
JOURNAL ARTICLE
José A Câncio Martins Bissaia Barreto, Maria I Táboas Simões, Gonçalo Gomes Engenheiro, Joana I Ferreira Matos, Joana A Rodrigues Leal
Overactive bladder (OAB) is the most common voiding dysfunction in children; however, nonneurogenic or idiopathic OAB remains poorly studied. First-line treatment includes conservative measures; however, as many patients are refractory, have adverse effects, or are contraindicated for anticholinergics, new options must be explored. This review covers the use of intravesical botulinum toxin (BoNT) for idiopathic OAB treatment in children, emphasizing its efficacy, safety, differences between toxins, doses, and injection techniques...
March 2024: Current Urology
https://read.qxmd.com/read/38502289/an-evidence-based-update-on-anticholinergic-use-for-drug-induced-movement-disorders
#32
JOURNAL ARTICLE
Nora Vanegas-Arroyave, Stanley N Caroff, Leslie Citrome, Jovita Crasta, Roger S McIntyre, Jonathan M Meyer, Amita Patel, J Michael Smith, Khody Farahmand, Rachel Manahan, Leslie Lundt, Samantha A Cicero
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor blocking agents (DRBAs), including antipsychotics. The most common forms are drug-induced parkinsonism (DIP), dystonia, akathisia, and tardive dyskinesia (TD). Although rare, neuroleptic malignant syndrome (NMS) is a potentially life-threatening consequence of DRBA exposure. Recommendations for anticholinergic use in patients with DIMDs were developed on the basis of a roundtable discussion with healthcare professionals with extensive expertise in DIMD management, along with a comprehensive literature review...
March 19, 2024: CNS Drugs
https://read.qxmd.com/read/38497333/association-of-pneumonia-admission-with-polypharmacy-and-drug-use-in-community-dwelling-older-people
#33
JOURNAL ARTICLE
Hironobu Hamaya, Taro Kojima, Yukari Hattori, Masahiro Akishita
AIM: The purpose of the present study was to clarify the association of pneumonia admission with polypharmacy and specific drug use in community-dwelling older people. METHODS: Using health insurance and long-term care insurance data from Kure city in Japan, we retrospectively collected data for older community-dwelling people (aged ≥65 years) from April 2017 to March 2019. The outcome was pneumonia admission. We carried out multivariate logistic regression analysis to identify the association of pneumonia admission with polypharmacy (≥5 drugs), the use of psychotropic drugs or anticholinergics with adjustment for patient backgrounds, such as comorbidity, and the daily life independence level for the older people with disability...
March 18, 2024: Geriatrics & Gerontology International
https://read.qxmd.com/read/38484758/investigating-the-association-of-anticholinergic-burden-with-depression-in-older-adults-a-cross-sectional-study
#34
JOURNAL ARTICLE
Neslihan Kayahan Satış, Mehmet İlkin Naharcı
BACKGROUND: Although depression and anticholinergic drug use are common comorbidities that impair health status in later life, there are insufficient data on their relationship. This study aimed to investigate the relationship between depressive symptoms and anticholinergic use in older individuals. METHODS: Community-dwelling older adults (≥65 years) admitted to the tertiary referral geriatric outpatient clinic were included. Participants were evaluated for depressive symptoms using the Geriatric Depression Scale (GDS) with a cut-off score of ≥6 for depression...
March 14, 2024: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://read.qxmd.com/read/38484241/comparing-impact-of-overactive-bladder-therapies-on-nocturia
#35
JOURNAL ARTICLE
Feven W Getaneh, Paul Kolm, Hailegeorgis Awulachew, Cheryl B Iglesia, Alexis A Dieter
IMPORTANCE: Nocturia is a significant symptom in overactive bladder with little data regarding the impact of overactive bladder treatments on nocturia. OBJECTIVES: Compare the effect of anticholinergic (AC) medication, onabotulinum toxin A (BTX), and sacral neuromodulation (SNM) on nocturia. STUDY DESIGN: Secondary analysis of the ABC and ROSETTA trials using data from the National Institutes of Health Data and Specimen Hub database. Patients reporting mean ≥2 voids/night on 3-day diary were included and divided into cohorts by treatment: the ABC trial: (1) AC and (2) BTX 100 units, and the ROSETTA trial: (3) BTX 200 units and (4) SNM...
March 1, 2024: Urogynecology (Phila)
https://read.qxmd.com/read/38484234/a-comparison-of-u-s-individual-and-family-plan-medication-coverage-for-overactive-bladder
#36
JOURNAL ARTICLE
Neha G Gaddam, Megan B Wallace, Alexis A Dieter
IMPORTANCE: There is strong evidence for long-term cognitive effects with anticholinergic use. Differences in insurance coverage of anticholinergics and beta-3 agonists hinder individualization of overactive bladder (OAB) treatment. OBJECTIVES: The aims of the study were to assess individual and family health insurance plan coverage for select OAB medications and to compare coverage of preferred medications to those with a greater risk of cognitive dysfunction. STUDY DESIGN: This cross-sectional study analyzed formularies for the top 7 U...
March 1, 2024: Urogynecology (Phila)
https://read.qxmd.com/read/38482514/investigating-the-impact-of-polypharmacy-and-anticholinergic-medication-burden-on-objective-cognitive-performance-in-adults-with-multiple-sclerosis
#37
JOURNAL ARTICLE
Joanie Huebner, Jade Robichaud, Julia S Cozart, Crystal Burkhardt, Sharon G Lynch, Jared M Bruce
BACKGROUND: Polypharmacy, or the use of 5 or more daily medications, is common in adults with multiple sclerosis (MS), and is often due to various physical, cognitive, and emotional symptoms. However, research regarding the association between polypharmacy and cognitive outcomes in MS is sparse. Furthermore, individuals with MS often use medications with anticholinergic properties, which are commonly associated with cognitive impairment and other central nervous system adverse effects...
2024: International Journal of MS Care
https://read.qxmd.com/read/38478365/association-of-anticholinergic-drug-burden-with-cognitive-and-functional-decline-over-time-in-dementia-with-lewy-bodies-1-year-follow-up-study
#38
JOURNAL ARTICLE
Cemile Ozsurekci, Neslihan Kayahan Satis, Sultan Keskin Demircan, Mehmet Ilkin Naharci
BACKGROUND: The purpose of this study was to investigate the relationship between anticholinergic burden (ACB), and cognitive and functional alterations in patients with dementia of Lewy bodies (DLB) during a 1-year follow-up period. METHODS: This cohort study included patients diagnosed with DLB admitted to a tertiary geriatric outpatient clinic. Cognition, functional performance, and nutritional status were assessed at baseline, 6 months, and 12 months during the follow-up period...
March 2024: Clinical Neuropharmacology
https://read.qxmd.com/read/38467994/cumulative-anticholinergic-burden-and-its-predictors-among-older-adults-with-alzheimer-s-disease-initiating-cholinesterase-inhibitors
#39
JOURNAL ARTICLE
Ashna Talwar, Satabdi Chatterjee, Jeffrey Sherer, Susan Abughosh, Michael Johnson, Rajender R Aparasu
BACKGROUND: Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties. However, concomitant use of cholinesterase inhibitors (ChEIs) and anticholinergic burden can nullify the benefit of the treatment and worsen Alzheimer's disease (AD). A literature gap exists regarding the extent of the cumulative anticholinergic burden and associated risk factors in AD. Therefore, this study evaluated the prevalence and predictors of cumulative anticholinergic burden among patients with AD initiating ChEIs...
March 11, 2024: Drugs & Aging
https://read.qxmd.com/read/38465631/rivastigmine-for-the-management-of-anticholinergic-delirium
#40
JOURNAL ARTICLE
Angela L Chiew, Amanda G Holford, Betty S H Chan, Katherine Z Isoardi
INTRODUCTION: Anticholinergic agents are commonly taken in overdose, often causing delirium. The spectrum of anticholinergic delirium ranges from mild agitation to severe behavioural disturbance. Physostigmine is an effective treatment for anticholinergic delirium, but its availability is limited. As rivastigmine is readily available, it has been used to manage anticholinergic delirium; however, there is limited research investigating its use. METHOD: This was a retrospective review of patients with anticholinergic delirium treated in two toxicology units with rivastigmine (oral capsule or transdermal patch) from January 2019 to June 2023...
February 2024: Clinical Toxicology
keyword
keyword
55697
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.