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https://www.readbyqxmd.com/read/29901309/-current-prospects-for-improving-the-quality-of-life-of-patients-with-internal-stents
#1
A G Martov, D V Ergakov, A B Novikov
Internal drainage of the upper urinary tract by stenting is a common urological procedure. The use of stenting in modern urological practice is on the rise due to widespread adoption of modern endourological, laparoscopic, percutaneous and high-tech robotic interventions. The presence of a stent in the patients body may cause stent-related symptoms and negatively affect the quality of life, resulting in additional outpatient visits and hospitalizations. The review provides an analysis of the causes, diagnostic evaluation, prevention and treatment of stent-related symptoms...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29896933/anticholinergic-and-sedative-medications-and-the-risk-of-vertigo-or-dizziness-in-the-german-primary-care-setting-a-matched-case-control-study-from-the-content-registry
#2
Amanda Phillips, Ralf Strobl, Eva Grill, Gunter Laux
PURPOSE: To date, there is little information on the utilization of anticholinergic and sedative (AS) medications to vertigo or dizziness (VoD) patients in the German primary care setting. The objective of this study was to evaluate AS medication use and its association with VoD within the German primary care setting. METHODS: Cases with VoD from the CONTENT (CONTinuous morbidity registration Epidemiologic NeTwork) database were 1:1 matched to controls on age, sex, and comorbidities by propensity score matching...
June 13, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29896133/the-impact-of-aging-psychotic-symptoms-medication-and-brain-derived-neurotrophic-factor-on-cognitive-impairment-in-japanese-chronic-schizophrenia-patients
#3
Kiyokazu Atake, Tomoyuki Nakamura, Nobuhisa Ueda, Hikaru Hori, Asuka Katsuki, Reiji Yoshimura
Background: Cognitive impairment in schizophrenia can result in considerable difficulty in performing functions of daily life or social rehabilitation. Cognitive impairment in schizophrenia is related to various factors, such as the psychotic severity, aging, medication, and brain-derived neurotrophic factor (BDNF). To date, however, no studies investigating the impact of these factors on cognitive functioning in chronic schizophrenia patients have been performed. Objective: The aim of this study is to identify those factors that influence the cognitive functioning in patients with chronic schizophrenia...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29892783/ureteral-stent-discomfort-and-its-management
#4
REVIEW
Katherine M Fischer, Michael Louie, Phillip Mucksavage
PURPOSE OF REVIEW: Ureteral stent placement is a very common urologic procedure and a necessary component of many minimally invasive surgeries including ureteroscopy. Despite its widespread use, stent placement results in bothersome urinary symptoms and pain in approximately 80% of patients. This review discusses the proposed mechanisms underlying ureteral stent-related symptoms and current approaches to symptom management and the evidence to support them. RECENT FINDINGS: Though it has been extensively studied, the exact cause of stent-related symptoms remains unknown but is likely related to irritation of the bladder by the distal curl of the stent and reflux of urine through the stent up to the renal pelvis and transmission of high pressures associated with this...
June 11, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29889041/-maintenance-of-the-efficacy-of-the-oxybutynin-patch-for-the-treatment-of-overactive-bladder-syndrome-despite-the-change-in-the-area-of-application-study-of-four-cases
#5
Sergio Merino Salas
The transdermal route for administration of anticholinergic drugs can provide efficacy with less systemic adverse effects. The transdermal oxybutynin patch (OXYTDS) offers advantages over oral administration for patients treated for Overactive bladder (OAB) syndrome. The limited evidence on the OXY-TDS patch application areas of the skin, makes difficult counseling patients who require a change to skin zones other than those recommended by the manufacturer. The preliminary experience of four patients included in this case report suggests that changing the application area for the OXY-TDS patch outside those skin areas recommended by the manufacturer, seems effective and safe in the treatment of OAB syndrome, regardless of the characteristics of the patients...
June 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29870958/the-oral-health-of-long-term-psychiatric-inpatients-in-singapore
#6
Di Ying Joanna Ngo, W Murray Thomson, Mythily Subramaniam, Edimansyah Abdin, Kok-Yang Ang
This cross-sectional study aims to describe the dental caries experience, treatment needs, and experience of dry mouth of 191 long-term psychiatric inpatients in Singapore. Medical history, dental caries experience [represented by the Decayed Missing or Filled Teeth index (DMFT)], salivary flow, and treatment needs were recorded. Information on brushing, pain (when eating), and xerostomia was gathered. Bivariate analysis was used to examine the associations of DMFT, saliva flow, the presence of salivary gland hypofunction (SGH), and xerostomia...
May 22, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29869076/therapeutic-symptomatic-strategies-in-the-parasomnias
#7
REVIEW
Raffaele Manni, Gianpaolo Toscano, Michele Terzaghi
PURPOSE OF REVIEW: The purpose of this review was to discuss the currently available pharmacologic and non-pharmacologic treatment options for parasomnias. RECENT FINDINGS: Recent pathophysiological findings about sleep structure in parasomnias helped understanding several drug mechanisms of action. Serotoninergic theory accounts for the effect of serotoninergic drugs. Study about spectral analysis of sleep showed the effect of clonazepam on spectral bands. Cannabinoids proved to be effective in some of parasomnias, as in many other neurological disorders...
June 5, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29866492/-coital-incontinence
#8
M Moutounaïck, G Miget, M Teng, F Kervinio, C Chesnel, A Charlanes, F Le Breton, G Amarenco
INTRODUCTION: Urinary incontinence may seriously impact quality of life, self-image and subsequently the sexual life. Beside this fact, urinary leakage can specifically occur during sexual intercourse, formally named coital incontinence, and thus lead to specific alteration of the sexual life. AIM: To analyse the prevalence, pathophysiological mechanisms and possible therapeutic options for coital urinary incontinence. METHODS: Related terms to urinary incontinence and sexual dysfunction were search on PubMed database...
June 1, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29861323/management-of-atrial-fibrillation-in-the-athlete
#9
Hariharan Raju, Jonathan M Kalman
Atrial fibrillation (AF) is a recognised arrhythmic risk of endurance sports participation, predominantly affecting middle-aged men who are lifelong athletes. Affected athletes were historically included in the category of lone AF, although specific pathophysiological processes apply to this condition, referred to as exercise-related AF. Younger non-endurance athletes may also present with AF, particularly when associated with co-existing cardiomyopathy or arrhythmia syndrome. Management of exercise-related AF is largely based on evidence from randomised trials in non-athletes...
May 8, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29849323/when-too-much-is-enough-pediatric-cyproheptadine-overdose-with-confirmatory-level
#10
Terrance McGovern, Justin McNamee, Steven Marcus, Josh Kashani
Cyproheptadine is an H-1 antihistamine with anticholinergic and antiserotonergic effects. Cyproheptadine's most common use has been in the management cold-induced urticaria. It is often used in primary care for its side effect of appetite stimulation. Recently there has been increasing interest in its use in the treatment of drug-induced serotonin syndrome. Cyproheptadine overdose is uncommonly reported in the medical literature. We report the rare case of a pediatric cyproheptadine overdose with a confirmatory cyproheptadine level...
August 2017: Clinical practice and cases in emergency medicine
https://www.readbyqxmd.com/read/29844889/pantothenate-kinase-associated-neurodegeneration-clinical-aspects-diagnosis-and-treatments
#11
Saeed Razmeh, Amir Hassan Habibi, Maryam Orooji, Elham Alizadeh, Karim Moradiankokhdan, Behroz Razmeh
Pantothenate Kinase-Associated Neurodegeneration (PKAN) is an autosomal recessive disorder characterized by a mutation in the PANK 2 gene. The clinical presentation may range from only speech disorder to severe generalized dystonia, spasticity, Visual loss, dysphagia and dementia. The hallmark of this disease is eyes of the tiger sign in the medial aspect of bilateral globus pallidus on T2-weighted MRI that is a hyperintense lesion surrounded by hypointensity. Common treatments for PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal baclofen, Iron chelation drugs and surgical procedures such as ablative pallidotomy or thalamotomy, Deep brain stimulation...
March 30, 2018: Neurology International
https://www.readbyqxmd.com/read/29802783/the-impact-of-bowel-management-in-alleviating-symptoms-of-urinary-incontinence-in-spina-bifida-patients-with-overactive-bladder-and-detrusor-sphincter-dyssynergia
#12
Zoran Radojicic, Sasa Milivojevic, Natasa Milic, Jelena Milin Lazovic, Marija Lukac, Aleksandar Sretenovic
OBJECTIVE: To examine the effects of bowel management on urinary incontinence in spina bifida patients with overactive bladder and detrusor sphincter dyssynergia. MATERIALS AND METHOD: The research was carried out over the 2014-2017 period. The first group consisted of 35 patients who were administered bowel management combined with anticholinergic medication therapy and clean intermittent catheterization (CIC). The second group consisted of 35 patients who were treated only with anticholinergic medication therapy and CIC...
May 26, 2018: BJU International
https://www.readbyqxmd.com/read/29800005/association-of-anticholinergic-drug-use-with-risk-for-late-age-related-macular-degeneration
#13
Gauthier Aldebert, Jean-Luc Faillie, Dominique Hillaire-Buys, Thibault Mura, Isabelle Carrière, Cécile Delcourt, Catherine Creuzot-Garcher, Max Villain, Vincent Daien
Importance: Amyloid-β is a major component of retinal drusen, the primary lesions of age-related macular degeneration (AMD), and autopsy and animal models suggested that anticholinergic drug (ACD) use increased brain amyloid-β deposition. Objective: To investigate the association between exposure to ACDs and late AMD (features of neovascular AMD or geographic atrophy of the retinal pigment epithelium in at least 1 eye). Design, Setting and Participants: A multicenter case-control study in 4 French ophthalmologic centers comprising 200 cases with late AMD and 200 controls enrolled from July 2016 to June 2017...
May 24, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29794201/clinical-pharmacology-of-bronchodilator-medications
#14
Dennis M Williams, Bruce K Rubin
Obstructive lung diseases, including asthma and COPD, are characterized by air-flow limitation. Bronchodilator therapy can often decrease symptoms of air-flow obstruction by relaxing airway smooth muscle (bronchodilation), decreasing dyspnea, and improving quality of life. In this review, we discuss the pharmacology of the β agonist and anticholinergic bronchodilators and their use, particularly in asthma and COPD. Expanding knowledge of receptor subtypes and G-protein signaling, agonist and antagonist specificity, and drug delivery have led to the introduction of safer medications with fewer off-target effects, medications with longer duration of action that may improve adherence, and more effective and efficient aerosol delivery devices...
June 2018: Respiratory Care
https://www.readbyqxmd.com/read/29787370/how-long-do-we-have-to-treat-overactive-bladder-syndrome-oab-a-questionnaire-survey-of-canadian-urologists-and-gynecologists
#15
Mikolaj Przydacz, Lysanne Campeau, Jens-Erik Walter, Jacques Corcos
INTRODUCTION: Overactive bladder syndrome (OAB) is a highly prevalent and costly condition worldwide with negative impact on health-related quality of life. Although many guidelines exist and anticholinergics are considered to be the mainstay of pharmacological treatment, data are lacking regarding optimal treatment duration. Therefore, the aim of this study was to determine practice patterns of Canadian urologists and gynecologists regarding duration of OAB pharmacotherapy. METHODS: A 14-question survey was designed and survey links (English and French) were sent by email to all practicing urologists and gynecologists registered with the Canadian Urological Association and the Society of Obstetricians and Gynecologists of Canada via the associations' email lists...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29784160/systemic-medication-usage-in-glaucoma-patients
#16
Tenley Bower, Deborah Anne Samek, Ahmed Mohammed, Ali Mohammed, Paul Kasner, David Camoriano, Oscar Kasner
OBJECTIVE: To study the prevalence of the systemic use of some common classes of medications by glaucoma patients and their relationship to the prevalence and severity of chronic open-angle glaucoma (COAG) and primary-angle closure glaucoma (PACG). DESIGN: Observational prospective single-centre cross-sectional study. METHODS: Glaucoma patients or their pharmacist provided an updated list of all systemic medications that they presently use...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29781879/cognitive-burden-of-common-non-antiretroviral-medications-in-hiv-infected-women
#17
Leah H Rubin, Kendra K Radtke, Seenae Eum, Bani Tamraz, Krithika N Kumanan, Gayle Springer, Pauline M Maki, Kathryn Anastos, Daniel Merenstein, Roksana Karim, Kathleen M Weber, Deborah Gustafson, Ruth M Greenblatt, Jeffrey R Bishop
OBJECTIVE: The aging HIV population has increased comorbidity burden and consequently non-antiretroviral (ARV) medication utilization. Many non-ARV medications have known neurocognitive-adverse effects ("NC-AE medications"). We assessed the cognitive effects of NC-AE medications in HIV+ and HIV- women. METHODS: 1558 participants (1037 HIV+; mean age 46) from the Women's Interagency HIV Study completed a neuropsychological test battery between 2009 and 2011...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29778822/formulation-techniques-for-high-dose-dry-powders
#18
Ashlee D Brunaugh, Hugh D C Smyth
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint...
May 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29770467/anticholinergic-load-negatively-correlates-with-recovery-of-cognitive-activities-of-daily-living-for-geriatric-patients-after-stroke-in-the-convalescent-stage
#19
E Kose, T Hirai, T Seki, S Hidaka, T Hamamoto
WHAT IS KNOWN AND OBJECTIVE: Anticholinergic drugs are associated with risks of falls, confusion and cognitive dysfunction. However, the effect of anticholinergic drug use on rehabilitation outcomes after a stroke is poorly documented. We therefore aimed to establish whether the anticholinergic load was associated with functional recovery among geriatric patients convalescing after stroke. METHOD: Consecutive geriatric stroke patients admitted and discharged from a convalescence rehabilitation ward between 2010 and 2016 were included in this retrospective cohort study...
May 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29768338/botulinum-toxin-injection-to-improve-functional-independence-and-to-alleviate-parenting-stress-in-a-child-with-advanced-pantothenate-kinase-associated-neurodegeneration-a-case-report-and-literature-review
#20
REVIEW
Cho-I Lin, Kuan-Lin Chen, Ta-Shen Kuan, Sheng-Han Lin, Wei-Pin Lin, Yu-Ching Lin
RATIONALE: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disease. Progressive motor symptoms such as dystonia and spasticity begin in childhood and relentlessly become incapacitating later in life. Treatments including anticholinergics and iron chelation are usually ineffective. Botulinum toxin type A (BoNT-A) is effective for adult patients with dystonia or spasticity. PATIENT CONCERNS: We reported a 10-year-old female patient with advanced PKAN, manifesting as generalized dystonia and spasticity...
May 2018: Medicine (Baltimore)
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