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https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#1
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28508455/a-multicenter-real-life-study-of-the-efficacy-of-an-alpha-blocker-with-or-without-anticholinergic-agent-imidafenacin-treatment-in-patients-with-lower-urinary-tract-symptoms-benign-prostatic-hyperplasia-and-storage-symptoms
#2
Seok Cho, Soon-Sun Kwon, Kwang Woo Lee, Tag Keun Yoo, Dong Gil Shin, Soo Woong Kim, Jae Hyun Bae, Hoon Choi, Young Ho Kim
AIMS: To evaluate the efficacy and safety of combination therapy comprising a short-acting anticholinergic, imidafenacin and an alpha-blocker compared with monotherapy with an alpha-blocker only in men with lower urinary tract symptoms (LUTS) and storage symptoms. METHODS: The 12-week, prospective, double-blind, randomised trial enrolled men with LUTS and storage symptom. The inclusion criteria were a total International Prostate Symptom Score (IPSS) ≥12, an IPSS question 4 score ≥2, ≥8 micturitions in 24 hours, and a prostate volume >20 mL...
May 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507653/use-of-potentially-inappropriate-medications-among-ambulatory-home-dwelling-elderly-patients-with-dementia-a-review-of-the-literature
#3
Tejal Patel, Karen Slonim, Linda Lee
BACKGROUND: Older adults with dementia are at high risk for drug-related adverse outcomes. While much is known about potentially inappropriate medication use in older adults, its prevalence and characteristics among those with dementia are not as well elucidated. We conducted a literature review to examine the prevalence of potentially inappropriate medication use among home-dwelling older adults with dementia. Our secondary aim was to determine the most frequently implicated medications and factors associated with potentially inappropriate medication use...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28505920/re-is-self-reported-adherence-associated-with-clinical-outcomes-in-women-treated-with-anticholinergic-medication-for-overactive-bladder
#4
Alan J Wein
No abstract text is available yet for this article.
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/28503836/role-of-anticholinergic-burden-in-primary-care-patients-with-first-cognitive-complaints
#5
G Grande, I Tramacere, D L Vetrano, F Clerici, S Pomati, C Mariani, G Filippini
BACKGROUND AND PURPOSE: Drugs with anticholinergic properties might have a negative impact on cognition, but findings are still conflicting. The association was evaluated between anticholinergic drugs and cognitive performance in primary care patients with first cognitive complaints. METHODS: From April 2013 to March 2014, 353 general practitioners administered the Mini-Mental State Examination (MMSE) to patients presenting with first cognitive complaints. Drug history was collected and the anticholinergic cognitive burden (ACB) was scored and categorized as ACB 0, ACB 1 and ACB 2+...
May 15, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28503324/a-5-day-antibiotic-course-for-treatment-of-intermittent-catheter-associated-urinary-tract-infection-in-patients-with-spinal-cord-injury
#6
Jean-Gabriel Previnaire, Morgane Le Berre, Elisabeth Hode, Vincent Dacquet, Hemanou Bordji, Pierre Denys, Jean-Marc Soler
INTRODUCTION: This was a retrospective monocentric study conducted at Centre Calvé, France, with the objective of evaluating the effectiveness of a 5-day course of antibiotics for symptomatic (mild urinary tract infection, UTI) or asymptomatic (aBact) bacteriuria in patients with spinal cord injury on intermittent catheterization. CASE PRESENTATION: This study was conducted from May 2013 to September 2016. Antibiotic selection always followed culture collection and analysis of antibiograms...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28503231/onabotulinumtoxina-for-the-treatment-of-idiopathic-overactive-bladder-is-effective-and-safe-for-repeated-use
#7
Kevin Carlson, Andrea Civitarese, Richard Baverstock
INTRODUCTION: The objective of this study was to compare efficacy and safety outcomes between patients receiving onabotulinum-toxinA (OnabotA) for the first time and those receiving a repeat injection. METHODS: Data collected before and after OnabotA injection were extracted from a clinical registry. Patients were classified into either first or repeat injection subgroups. Efficacy was measured by the change in use of oral bladder medications, the number of voids per day or night, the frequency of urinary incontinence (UI) episodes, and patient-reported outcomes...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28502414/acute-bronchodilator-responses-to-%C3%AE-2-agonist-and-anticholinergic-agent-in-copd-their-different-associations-with-exacerbation
#8
Satoshi Konno, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, Hirokazu Kimura, Hiroki Kimura, Masaharu Nishimura
BACKGROUND: Acute bronchodilator response (BDR) is a potential phenotypic characteristic of COPD. However, the clinical factors associated with BDR in patients with COPD remain unclear, particularly for BDR to anticholinergic agents. OBJECTIVES: We aimed to clarify the clinical factors associated with BDR to β2-agonist and/or anticholinergic agent, considering time-associated variations of BDR. We also evaluated the association between BDR and clinical course of COPD...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28491929/dexmedetomidine-as-an-adjunct-to-treat-anticholinergic-toxidrome-in-children
#9
Krista Cowan, Rebecca A Landman, Arun Saini
No abstract text is available yet for this article.
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28490237/phytochemistry-and-pharmacological-activities-of-the-genus-swertia-gentianaceae-a-review
#10
Jie Li, Yan-Li Zhao, Heng-Yu Huang, Yuan-Zhong Wang
Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites...
May 11, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28489007/-frequency-of-symptoms-and-drug-treatment-among-dying-patients-in-the-last-24-hours-of-life-at-landspitali-the-national-university-hospital-of-iceland-and-in-nursing-homes
#11
Svandis Iris Halfdanardottir, Kristin Lara Olafsdottir, Valgerdur Sigurdardottir
INTRODUCTION: The purpose of this study was to evaluate the frequency of 5 common symptoms and drug treatments prescribed and given in the last 24 hours of life in 11 medical units at Landspitali National University Hospital of Iceland (LUH) and in 7 nursing homes (NH). MATERIAL AND METHODS: Data was collected retrospectively from 232 charts of patients who died in 2012, using documentation in the Liverpool Care Pathway (LCP) and the medication management system...
May 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28486308/effect-of-n-desalkylquetiapine-quetiapine-plasma-level-ratio-on-anxiety-and-depression-in-bipolar-disorder-a-prospective-observational-study
#12
C Rovera, M C Mauri, C Di Pace, S Paletta, A Reggiori, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura
BACKGROUND: The aim of this study was to analyse the relationships between quetiapine and N-desalkylquetiapine plasma levels and clinical improvement, particularly, in regard to depressive and anxious symptoms and to hostility. METHODS: This was a prospective observational study that involved 37 outpatients diagnosed as having bipolar disorder I or II. All the patients were observed during a clinical acute and postacute phase. Patients were prescribed 50-800 mg of quetiapine...
May 5, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28484598/the-evidence-on-tiotropium-bromide-in-asthma-from-the-rationale-to-the-bedside
#13
REVIEW
Dejan Radovanovic, Pierachille Santus, Francesco Blasi, Marco Mantero
Severe and poorly controlled asthma still accounts for a great portion of the patients affected. Disease control and future risk management have been identified by international guidelines as the main goals in patients with asthma. The need for new treatment approaches has led to reconsider anticholinergic drugs as an option for asthma treatment. Tiotropium is the first anticholinergic drug that has been approved for children and adults with poorly controlled asthma and is currently considered as an option for steps 4 and 5 of the Global Initiative for Asthma...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28483466/role-of-body-mass-index-in-school-aged-children-with-lower-urinary-tract-dysfunction-does-weight-classification-predict-treatment-outcome
#14
Angela M Arlen, Christopher S Cooper, Traci Leong
INTRODUCTION: Lower urinary tract (LUT) dysfunction comprises a large percentage of pediatric urology referrals. Childhood obesity is a major health concern, and has been associated with voiding symptoms. We assessed the impact of body mass index (BMI) on treatment outcomes of children presenting with LUT or bladder-bowel dysfunction (BBD). STUDY DESIGN: Children aged 5-17 years diagnosed with non-neurogenic LUT dysfunction and no prior urologic diagnoses were identified...
April 25, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28483009/clinical-and-functional-characteristics-of-nursing-facility-residents-with-opioid-induced-constipation
#15
Carrie Allen, Barbara J Zarowitz, Terrence O'Shea, Catherine Datto, Temitope Olufade
OBJECTIVE: Our goal was to determine the prevalence, clinical characteristics, and treatment differences of opioid-induced constipation (OIC) in older adults with noncancer pain compared with opioid-treated patients without OIC. DESIGN: Retrospective database analysis. SETTING: United States nursing facilities: Patients, Participants, facility residents. INTERVENTIONS: None. MAIN OUTCOME MEASURE(S): Minimum data set and prescription claims, pain, impaired cognition, falls, delirium, and drug treatment...
May 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28478755/-mirabegron-a-breakthrough-in-overactive-bladder-syndrome
#16
Almudena Maestro Nombela, María José Almodóvar Carretón, Virginia Saavedra Quirós, Carlos Barreda Velázquez, Lucía Jamart Sánchez
Overactive bladder syndrome is a condition with high prevalence, which has a negative impact on patients' quality of life. A drug with a novel mechanism of action has been recently approved: mirabegron. The objective of this study is to review the scientific evidence available on mirabegron, with the aim to analyze its efficacy, safety and cost, and thus estimate its role within current pharmacotherapy. Methods: The effectiveness and safety of mirabegron were analyzed through an evaluation of scientific evidence...
May 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28468509/effect-of-trospium-chloride-therapy-on-intraocular-pressure-and-tear-secretion-in-overactive-bladder-patients
#17
Ali Riza Turkoglu, Neslihan Parmak Yener, Soner Coban, Muhammet Guzelsoy, Ali Emul, Murat Demirbas, Hakan Demirci
PURPOSE: To investigate the effect of trospium chloride, which has an anticholinergic effect, used in overactive bladder (OAB) treatment on the intraocular pressure (IOP) and tear secretion after 12 weeks of treatment. MATERIALS AND METHODS: This prospective study was performed at a single center between October 2014 and January 2016. A detailed history was obtained from the female OAB patients at the eye outpatient department. After checking the exclusion criteria, oral trospium chloride 30 mg bd was started...
May 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28467609/comparing-anticholinergic-persistence-and-adherence-profiles-in-overactive-bladder-patients-based-on-gender-obesity-and-major-anticholinergic-agents
#18
Lannah L Lua, Prathamesh Pathak, Vani Dandolu
AIMS: Overactive bladder (OAB) is highly prevalent particularly among obese patients and significantly impacts quality of life. Anticholinergics are the first-line treatment. The effect of obesity on medication compliance has not been studied. Our study evaluated gender- and obesity-specific adherence and persistence of anticholinergic medications in OAB. We also compared adherence and persistence on solifenacin to oxybutynin, tolterodine, and all anticholinergics combined. METHODS: Truven Marketscan Commercial Claims and Encounter database from 2005 to 2013 was used...
May 3, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28461989/is-overactive-bladder-in-the-female-surgically-curable-by-ligament-repair
#19
Bernhard Liedl, Hiromi Inoue, Yuki Sekiguchi, Max Haverfield, Peter Richardson, Alexander Yassourides, Florian Wagenlehner
INTRODUCTION: Overactive bladder (OAB) symptoms (urge, frequency, nocturia) are not generally considered surgically curable by learning institutions. The Integral Theory hypothesizes that OAB is a prematurely activated, but normal micturition reflex caused by loose suspensory ligaments and potentially curable surgically by repairing such ligaments. To test this hypothesis by surgical repair of loose cardinal and uterosacral ligaments in patients with 2(nd) degree or greater uterine/apical prolapse...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28459143/testosterone-deficiency-and-nocturia-a-review
#20
REVIEW
Kazuyoshi Shigehara, Koji Izumi, Atsushi Mizokami, Mikio Namiki
Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels...
April 2017: World Journal of Men's Health
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