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https://www.readbyqxmd.com/read/28433975/absolute-benefits-of-empagliflozin-in-type-2-diabetes-a-game-changer
#1
EDITORIAL
Cyrus R Kumana, Kathryn C B Tan, Bernard M Y Cheung
No abstract text is available yet for this article.
April 22, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28413187/noninvasive-fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography%C3%A3-is-this-just-another-new-diagnostic-test-or-the-long-awaited-game-changer
#2
Hiromasa Otake, Charles A Taylor, Hitoshi Matsuo, Nobuhiro Tanaka, Takashi Akasaka
Despite the clinical importance of ischemia evaluation, obtaining fractional flow reserve (FFR) value has, heretofore, only been available during invasive cardiac catheterization. Although there is a clear linkage between morphology and physiology, a significant gap still exists. FFR derived from coronary computed tomography angiography (FFRCT) is a novel method of quantifying the hemodynamic significance of coronary artery stenoses by translating morphological information into hemodynamic data. Improved diagnostic performance of FFRCThas been repeatedly demonstrated in comparison with coronary computed tomography angiography alone with an invasive FFR reference standard...
April 11, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28377276/encapsulation-systems-for-the-delivery-of-hydrophilic-nutraceuticals-food-application
#3
REVIEW
N P Aditya, Yadira Gonzalez Espinosa, Ian T Norton
Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers...
April 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28363738/ex-vivo-lung-perfusion-the-makings-of-a-game-changer
#4
EDITORIAL
J W Awori Hayanga
No abstract text is available yet for this article.
March 7, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28320774/3d-bioprint-me-a-socioethical-view-of-bioprinting-human-organs-and-tissues
#5
Niki Vermeulen, Gill Haddow, Tirion Seymour, Alan Faulkner-Jones, Wenmiao Shu
In this article, we review the extant social science and ethical literature on three-dimensional (3D) bioprinting. 3D bioprinting has the potential to be a 'game-changer', printing human organs on demand, no longer necessitating the need for living or deceased human donation or animal transplantation. Although the technology is not yet at the level required to bioprint an entire organ, 3D bioprinting may have a variety of other mid-term and short-term benefits that also have positive ethical consequences, for example, creating alternatives to animal testing, filling a therapeutic need for minors and avoiding species boundary crossing...
March 20, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28287846/will-the-first-approved-automated-insulin-delivery-system-be-a-game-changer-in-type-1-diabetes-management
#6
Jessica R Castle
No abstract text is available yet for this article.
March 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28249663/immunotherapy-in-squamous-cell-skin-carcinoma-a-game-changer
#7
Sravanthi Ravulapati, Cerena Leung, Nishant Poddar, Yifan Tu
No abstract text is available yet for this article.
February 26, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28246361/new-mouse-model-for-chronic-infections-by-gram-negative-bacteria-enabling-the-study-of-anti-infective-efficacy-and-host-microbe-interactions
#8
Daniel Pletzer, Sarah C Mansour, Kelli Wuerth, Negin Rahanjam, Robert E W Hancock
Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial infections that mimic human situations, where untreated infections can last for weeks. Here, we describe a simple murine cutaneous abscess model that enables chronic or progressive infections, depending on the subcutaneously injected bacterial strain. In this model, Pseudomonas aeruginosa cystic fibrosis epidemic isolate LESB58 caused localized high-density skin and soft tissue infections and necrotic skin lesions for up to 10 days but did not disseminate in either CD-1 or C57BL/6 mice...
February 28, 2017: MBio
https://www.readbyqxmd.com/read/28191676/discovery-of-skin-lymphocytes-was-a-game-changer-in-experimental-dermatology
#9
Tiago R Matos, Menno A de Rie
A substantial part of ongoing research in experimental dermatology focuses on skin T cells - for that reason we find important to highlight the pioneering work of Jan D. Bos et al. from 1987 (The skin immune system (SIS): Distribution and immunophenotype of lymphocyte subpopulations in normal skin). This key article set the record straight, once and for all, about the presence of lymphocytes in healthy skin; characterized the immunophenotypes of subpopulations, quantified these cells, and studied their location...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28183941/game-changers
#10
Angela Chuang
No abstract text is available yet for this article.
February 10, 2017: Science
https://www.readbyqxmd.com/read/28160728/point-of-care-testing-poct-in-molecular-diagnostics-performance-evaluation-of-genexpert-hcv-rna-test-in-diagnosing-and-monitoring-of-hcv-infection
#11
Ekta Gupta, Pragya Agarwala, Guresh Kumar, Rakhi Maiwall, Shiv Kumar Sarin
BACKGROUND: Molecular testing at the point-of-care may turn out to be game changer for HCV diagnosis and treatment monitoring, through increased sensitivity, reduced turnaround time, and ease of performance. One such assay GeneXpert(®) has recently been released. OBJECTIVES: Comparative analysis between performances of GeneXpert(®) and Abbott HCV-RNA was done. STUDY DESIGN: 174 HCV infected patients were recruited and, one time plasma samples from 154 patients and repeated samples from 20 patients, obtained at specific treatment time-points (0, 4, 12 and 24) weeks were serially re-tested on Xpert(®)...
March 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28135596/will-demography-defeat-river-rehabilitation-efforts-the-case-of-the-river-jordan
#12
REVIEW
Alon Tal
In the age-old debate between technological optimists and pessimists, desalination has been hailed as a "game changer" that can fundamentally alter the dynamics of water management under conditions of scarcity. While water from desalination facilities can reduce uncertainties in municipal supply, they are unlikely to replace the missing flow required to rehabilitate rivers and streams. The Jordan River is an iconic, but highly degraded water body whose restoration has been the subject of extensive research as well as numerous proposals and strategies...
March 15, 2017: Water Research
https://www.readbyqxmd.com/read/28131621/talkin-about-my-re-generation-the-who-of-intrinsic-retinal-stem-cells
#13
Deborah C Otteson
World-wide, two degenerative retinal diseases, glaucoma and age-related macular degeneration, are estimated to affect more than 12% of individuals over the age of 40 (Tham et al., 2014; Wong et al., 2014). Current therapies can slow progression, but cannot restore lost neurons or vision. Thus, there is increasing interest in developing strategies for therapeutic retinal regeneration. Nearly 50years of research on retinal neurogenesis and regeneration has identified Müller glia as intrinsic retinal stem cells in teleost fish...
March 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28121595/integrated-plans-fertile-for-real-world-evidence
#14
Frank Diamond
But most insurers are taking a wait-and-see attitude even though in some clinical areas, such as diabetes, real-world evidence (RWE) has been a true game-changer. Payers have a pessimistic view that RWE can help them. It doesn't help that respected voices in health care agree.
January 2017: Managed Care
https://www.readbyqxmd.com/read/28111761/what-is-the-mechanism-of-ketamine-s-rapid-onset-antidepressant-effect-a-concise-overview-of-the-surprisingly-large-number-of-possibilities
#15
REVIEW
S E Strasburger, P M Bhimani, J H Kaabe, J T Krysiak, D L Nanchanatt, T N Nguyen, K A Pough, T A Prince, N S Ramsey, K H Savsani, L Scandlen, M J Cavaretta, R B Raffa
WHAT IS KNOWN AND OBJECTIVE: Abundant clinical data now confirm that ketamine produces a remarkable rapid-onset antidepressant effect - hours or days - in contrast to the delayed onset (typically weeks) of current antidepressant drugs. This surprising and revolutionary finding may lead to the development of life-saving pharmacotherapy for depressive illness by reducing the high suicide risk associated with the delayed onset of effect of current drugs. As ketamine has serious self-limiting drawbacks that restrict its widespread use for this purpose, a safer alternative is needed...
January 22, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28103791/high-virulence-does-not-necessarily-impede-viral-adaptation-to-a-new-host-a-case-study-using-a-plant-rna-virus
#16
Anouk Willemsen, Mark P Zwart, Santiago F Elena
BACKGROUND: Theory suggests that high virulence could hinder between-host transmission of microparasites, and that virulence therefore will evolve to lower levels. Alternatively, highly virulent microparasites could also curtail host development, thereby limiting both the host resources available to them and their own within-host effective population size. In this case, high virulence might restrain the mutation supply rate and increase the strength with which genetic drift acts on microparasite populations...
January 19, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28092219/the-21st-century-cures-act-pharmacoeconomic-boon-or-bane
#17
Roger Lee Mendoza
Barriers to entry in healthcare markets constitute one of the overriding concerns of health economists. The recent enactment of the 21st Century Cures Act in the United States reduces statutory entry barriers to the discovery, development, testing, and licensing of drugs and medical devices. Drug and device makers also see the burdensome and time-consuming requirements of the Food and Drug Administration?s approval process as key barriers to lowering the costs of their products, considering it takes a decade of research amounting to $1 billion just to bring a single drug to the market...
April 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28076727/a-game-changer-for-eye-care-for-diabetes
#18
Hugh R Taylor
No abstract text is available yet for this article.
January 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28028326/practice-management-the-game-changer
#19
REVIEW
Paul Pessis
The reimbursement landscape is undergoing significant changes. Practice management, which encompasses reimbursement, is becoming increasingly more important in securing business success. Each practitioner within a facility is responsible for fortifying the practice through thoughtful business protocols. Knowing legislation that impacts health care along with understanding the foundational components of reimbursement is key for keeping a practice financially healthy. Change is good, but making the changes is what counts! Legislation such as the Medicare Access and Chip Reauthorization Act defines the new payment models...
November 2016: Seminars in Hearing
https://www.readbyqxmd.com/read/27991687/graphite-to-graphene-total-conversion
#20
Matat Buzaglo, Ilan Pri Bar, Maxim Varenik, Liran Shunak, Svetlana Pevzner, Oren Regev
The rush to develop graphene applications mandates mass production of graphene sheets. However, the currently available complex and expensive production technologies are limiting the graphene commercialization. The addition of a protective diluent to graphite during ball-milling is demonstrated to result in a game-changer yield (>90%) of defect-free graphene, whose size is controlled by the milling energy and the diluent type.
February 2017: Advanced Materials
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