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https://www.readbyqxmd.com/read/28986509/why-targeting-psma-is-a-game-changer-in-the-management-of-prostate-cancer-%C3%A2-a-urologist-s-point-of-view
#1
Nicholas M Donin, Robert Reiter
Prostate-specific membrane antigen (PSMA), is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extra-prostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 years ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 years have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use...
October 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28940026/coronary-ct-angiography-derived-fractional-flow-reserve-the-game-changer-in-noninvasive-testing
#2
REVIEW
Bjarne Linde Nørgaard, Jesper Møller Jensen, Philipp Blanke, Niels Peter Sand, Mark Rabbat, Jonathon Leipsic
To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data RECENT FINDINGS: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA...
September 22, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28860875/extraglottic-airway-devices-technology-update
#3
REVIEW
Bimla Sharma, Chand Sahai, Jayashree Sood
Extraglottic airway devices (EADs) have revolutionized the field of airway management. The invention of the laryngeal mask airway was a game changer, and since then, there have been several innovations to improve the EADs in design, functionality, safety and construction material. These have ranged from changes in the shape of the mask, number of cuffs and material used, like rubber, polyvinylchloride and latex. Phthalates, which were added to the construction material in order to increase device flexibility, were later omitted when this chemical was found to have serious adverse reproductive outcomes...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28838474/percutaneous-coronary-interventions-in-patients-requiring-long-term-oral%C3%A2-anticoagulation-is-the-drug-coated-stent-a-potential-game-changer
#4
EDITORIAL
Jean-François Tanguay, Nathan Messas
No abstract text is available yet for this article.
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28836744/biosimilars-in-rheumatology-name-changers-or-game-changers
#5
Rohini Handa
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28831030/fda-s-new-plan-to-reduce-the-nicotine-in-cigarettes-to-sub-addictive-levels-could-be-a-game-changer
#6
EDITORIAL
Robert N Proctor
No abstract text is available yet for this article.
September 2016: Tobacco Control
https://www.readbyqxmd.com/read/28815441/pluripotent-stem-cells-in-adult-tissues-struggling-to-be-acknowledged-over-two-decades
#7
REVIEW
Deepa Bhartiya
Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. Besides embryonic stem cells (ES) and induced pluripotent stem cells (iPS), it has been postulated that pluripotent stem cells (PSCs) may also exist in various adult tissues. They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis...
August 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28803893/the-companion-dog-as-a-unique-translational-model-for-aging
#8
REVIEW
Andrea Mazzatenta, Augusto Carluccio, Domenico Robbe, Camillo Di Giulio, Alessandro Cellerino
The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer's disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections...
October 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28792918/game-changers
#9
Branwen Morgan, Annabel McGilvray
No abstract text is available yet for this article.
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28770513/selective-interleukin-23-p19-inhibition-another-game-changer-in-psoriasis-focus-on-risankizumab
#10
Tiago Torres
The history of psoriasis treatment has been marked by several milestones. Corticosteroids, cyclosporine, tumor necrosis factor alpha (TNF-α) inhibitors and, more recently, interleukin (IL)-17A inhibitors have revolutionized the treatment of psoriasis, each in its own way and time. The IL-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and selective IL-23p19 inhibition may bring several advantages with respect to IL-12/23p40 inhibition, or distal blockade of IL-17A or its receptor...
August 2, 2017: Drugs
https://www.readbyqxmd.com/read/28768387/general-surgery-s-game-changer-and-the-unanswered-question
#11
EDITORIAL
Jonathan B Koea
No abstract text is available yet for this article.
July 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28766054/mri-chest-a-game-changer
#12
REVIEW
Ashu Seith Bhalla, Manisha Jana
No abstract text is available yet for this article.
August 2, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28752001/ultrasound-a-game-changer
#13
EDITORIAL
Wael Saasouh, Alparslan Turan
No abstract text is available yet for this article.
June 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28729242/heading-for-trouble-is-dementia-a-game-changer-for-football
#14
EDITORIAL
A Rutherford, William Stewart, Davide Bruno
No abstract text is available yet for this article.
July 20, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#15
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28723999/moving-towards-south-south-international-health-debts-and-challenges-in-the-regional-health-agenda
#16
María Belén Herrero
The aim of this paper is twofold. First, it aims to investigate the increased interest in health as an important dimension of the foreign policy and diplomatic concerns together with the emergence of a new framework for regional health integration and regional health diplomacy. Second, it seeks to understand the role and practices of new regional blocs in the field of health and whether they are conducting to the emergence of new strategies for addressing health regional policies in South America. The regional policy process relates to health as a right...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28715943/introducing-treat-to-target-strategies-of-autoimmune-extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection
#17
REVIEW
Soledad Retamozo, Pilar Brito-Zerón, Luca Quartuccio, Salvatore De Vita, Manuel Ramos-Casals
The hepatitis C virus (HCV) is recognized as one of the hepatic viruses most often associated with extrahepatic manifestations (EHMs). It is currently accepted that cryoglobulinemic vasculitis (CV) is the key autoimmune extrahepatic disease associated with HCV infection. Therapeutic approaches have mainly been based on the use of old antiviral interferon (IFN)-based regimens and immunosuppressive therapies, often with an inadequate balance between therapeutic benefits and excess side effects. Areas covered: Therapeutic management of HCV patients with EHMs, including both non-autoimmune (cardiovascular, hematological, general features) and autoimmune complications (organ-specific and systemic autoimmune diseases)...
October 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28696529/fast-dynamic-visualizations-in-microfluidics-enabled-by-fluorescent-carbon-nanodots
#18
Yi Huang, Lian Xiao, Tingting An, Wenxiang Lim, Teckneng Wong, Handong Sun
Microfluidic systems have become a superior platform for explorations of fascinating fluidic physics at microscale as well as applications in biomedical devices, chemical reactions, drug delivery, etc. Exploitations of this platform are built upon the fundamental techniques of flow visualizations. However, the currently employed fluorescent materials for microfluidic visualization are far from satisfaction, which severely hinders their widespread applications. Here fluorescent carbon nanodots are documented as a game-changer, applicable in versatile fluidic environment for the visualization in microfluidics with unprecedented advantages...
July 11, 2017: Small
https://www.readbyqxmd.com/read/28693853/multidrug-therapy-for-leprosy-a-game-changer-on-the-path-to-elimination
#19
REVIEW
Cairns S Smith, Ann Aerts, Paul Saunderson, Joseph Kawuma, Etsuko Kita, Marcos Virmond
Leprosy is present in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability. Attempts to eliminate the disease have faced various obstacles, including characteristics of the causative bacillus Mycobacterium leprae: the long incubation period, limited knowledge about its mode of transmission, and its poor growth on culture media. Fortunately, the leprosy bacillus is sensitive to several antibiotics. The first antibiotic to be widely used for leprosy treatment was dapsone in the 1950s, which had to be taken over several years and was associated with increasing bacterial resistance...
September 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28692305/fight-fire-with-fire-gene-therapy-strategies-to-cure-hiv
#20
Jon Huyghe, Sips Magdalena, Linos Vandekerckhove
Human Immunodeficiency Virus (HIV) to date remains one of the most notorious viruses mankind has ever faced. Despite enormous investments in HIV research for more than 30 years an effective cure for HIV has been elusive. Areas covered: Combination antiretroviral therapy (cART) suppresses active viral replication, but is not able to eliminate the virus completely due to stable integration of HIV inside the host genome of infected cells and the establishment of a latent reservoir, that is insensitive to cART...
July 14, 2017: Expert Review of Anti-infective Therapy
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