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https://www.readbyqxmd.com/read/29431247/chlorhexidine-for-neonatal-infection-the-game-changer-we-ve-all-been-waiting-for
#1
EDITORIAL
Victoria Ponce Hardy
No abstract text is available yet for this article.
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29416272/is-retrograde-intrarenal-surgery-the-game-changer-in-the-management-of-upper-tract-calculi-a-single-center-single-surgeon-experience-of-131-cases
#2
Kandarp Priyakant Parikh, Ravi Jineshkumar Jain, Aditya Parikh Kandarp
Introduction: Success of any modality for stone disease needs to be evaluated in terms of Stone Free Rates (SFR), auxiliary procedures needed; complications and follow up. SFR in RIRS is subject to parameters like stone burden, location, number, hardness, composition; calyceal and ureter anatomy; use of ureteric access sheath (UAS); surgeon experience etc. Methods: The aim of this study is to evaluate the efficacy and safety of RIRS for managing upper tract stones...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29401032/hiv-prevention-drug-s-slow-uptake-undercuts-its-early-promise
#3
David Tuller
Initially billed as a game changer, Truvada has faced multiple obstacles to widespread adoption.
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29374681/stereotactic-body-radiation-therapy-for-liver-tumors-current-status-and-perspectives
#4
REVIEW
Hiroshi Doi, Naohito Beppu, Kazuhiro Kitajima, Kozo Kuribayashi
Surgical resection is the standard therapy for solitary primary or metastatic liver tumors. However, liver tumors are often unresectable at diagnosis and hepatectomy is invasive. Local therapies, such as radiofrequency ablation, are used instead, which can be challenging. Recent advances in modern radiotherapy, including stereotactic body radiation therapy (SBRT), have increased the use of radiotherapy as a curative modality. SBRT delivers ablative high doses of irradiation in small volumes. SBRT for liver tumors provided local control with potential survival benefits in patients with inoperable status...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29369733/clinical-applications-of-ultra-high-field-magnetic-resonance-imaging-in-multiple-sclerosis
#5
Matilde Inglese, Lazar Fleysher, Niels Oesingmann, Maria Petracca
Magnetic resonance imaging (MRI) is of paramount importance for the early diagnosis of multiple sclerosis (MS) and MRI findings are part of the MS diagnostic criteria. There is a growing interest in the use of ultra-high-field strength -7 Tesla- (7T) MRI to investigate, in vivo, the pathological substrate of the disease. Areas covered: An overview of 7T MRI applications in MS focusing on increased sensitivity for lesion detection, specificity of the central vein sign and better understanding of MS pathophysiology and discuss the implications for disease diagnosis, monitoring and treatment planning...
January 25, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29368737/china-s-ban-on-imported-plastic-waste-could-be-a-game-changer
#6
Tony R Walker
No abstract text is available yet for this article.
January 25, 2018: Nature
https://www.readbyqxmd.com/read/29353654/magnetic-resonance-imaging-guided-adaptive-radiation-therapy-a-game-changer-for-prostate-treatment
#7
REVIEW
Angela U Pathmanathan, Nicholas J van As, Linda G W Kerkmeijer, John Christodouleas, Colleen A F Lawton, Danny Vesprini, Uulke A van der Heide, Steven J Frank, Simeon Nill, Uwe Oelfke, Marcel van Herk, X Allen Li, Kathryn Mittauer, Mark Ritter, Ananya Choudhury, Alison C Tree
Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29341913/characterisation-of-pore-structures-of-pharmaceutical-tablets-a-review
#8
REVIEW
Daniel Markl, Alexa Strobel, Rüdiger Schlossnikl, Johan Bøtker, Prince Bawuah, Cathy Ridgway, Jukka Rantanen, Thomas Rades, Patrick Gane, Kai-Erik Peiponen, J Axel Zeitler
Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29330699/accounting-of-ghg-emissions-and-removals-from-forest-management-a-long-road-from-kyoto-to-paris
#9
REVIEW
Joachim H A Krug
BACKGROUND: Forests have always played an important role in agreeing on accounting rules during the past two decades of international climate policy development. Starting from activity-based gross-net accounting of selected forestry activities to mandatory accounting against a baseline-rules have changed quite rapidly and with significant consequences for accounted credits and debits. Such changes have direct consequences on incentives for climate-investments in forestry. There have also been strong arguments not to include forests into the accounting system by considering large uncertainties, procedural challenges and a fear of unearned credits corrupting the overall accounting system, among others...
January 3, 2018: Carbon Balance and Management
https://www.readbyqxmd.com/read/29312977/extracellular-vesicles-in-bile-a-game-changer-in-the-diagnosis-of-indeterminate-biliary-stenoses
#10
EDITORIAL
Seung Bae Yoon, Jae Hyuck Chang
No abstract text is available yet for this article.
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29304962/editorial-commentary-three-dimensional-printing-and-stem-cells-may-be-a-game-changer-for-recovery-after-anterior-cruciate-ligament-reconstruction
#11
EDITORIAL
Vipool K Goradia
Placing stem cells at the tendon-bone interface of a soft tissue anterior cruciate ligament (ACL) reconstruction in an animal model accelerates graft incorporation at 12 weeks. A 3D-printed scaffold used to deliver the stem cells completely degraded at 12 weeks. Future clinical application of similar technology may improve outcomes after ACL reconstruction.
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29286056/sacubitril-and-valsartan-fixed-combination-to-reduce-heart-failure-events-in-post-acute-myocardial-infarction-patients
#12
M Zaid Iskandar, C C Lang
Heart failure is a term used to define a constellation of symptoms and signs that are commonly attributed to the inability of the heart to produce a cardiac output that meets the demands of the body. It remains a deadly disease, affecting between 1-2% of the population, and is more common in the elderly, with around 6-10% of patients over 65 suffering from the condition. Sacubitril/valsartan (LCZ-696) is a combined neprilysin inhibitor and angiotensin AT1 receptor blocker approved in recent years for the treatment of chronic heart failure with reduced ejection fraction...
October 2017: Drugs of Today
https://www.readbyqxmd.com/read/29274719/hyperactive-factor-ix-padua-a-game-changer-for-hemophilia-gene-therapy
#13
Thierry VandenDriessche, Marinee K Chuah
No abstract text is available yet for this article.
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29244094/a-game-changer-for-the-aesthetic-surgery-journal
#14
Foad Nahai, Jeffrey M Kenkel
No abstract text is available yet for this article.
December 13, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29232103/game-changers-new-%C3%AE-lactamase-inhibitor-combinations-targeting-antibiotic-resistance-in-gram-negative-bacteria
#15
Karen Bush
Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime-avibactam and meropenem-vaborbactam have provided two novel therapeutic options for the treatment of multidrug-resistant infections caused by Gram-negative bacteria. Most importantly, these combination agents have satisfied an important medical need related to antibiotic-resistant Klebsiella pneumoniae that produce serine carbapenemases, especially the Klebsiella pneumoniae carbapenemase (KPC) enzymes. Both combinations contain non-β-lactam β-lactamase inhibitors of novel chemical classes not previously developed as antibacterial agents, the diazabicyclooctanes and cyclic boronic acid derivatives...
December 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29216016/why-the-cantos-is-a-game-changer-in-cardiovascular-medicine
#16
Antonio Abbate
No abstract text is available yet for this article.
December 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29214315/will-the-fda-s-new-tobacco-strategy-be-a-game-changer
#17
Rita Rubin
No abstract text is available yet for this article.
December 6, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29184675/possible-application-of-circulating-free-tumor-dna-in-non-small-cell-lung-cancer-patients
#18
REVIEW
Niki Karachaliou, Aaron E Sosa, Miguel Angel Molina, Margarita Centelles Ruiz, Rafael Rosell
Liquid biopsies have been heralded as a game changer in cancer management. Blood tests offer a minimally invasive, safe and sensitive complementary (or even alternative) approach for tissue biopsies. With lung cancer being the second most commonly diagnosed cancer and the leading cause of cancer deaths worldwide, due to the limitations of tissue sampling, liquid biopsies must urgently materialize in the clinic. In this short review, we will present the current applications of cell-free DNA (cfDNA) in lung cancer management, emphasizing on our own experience and previous work...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29173353/extracellular-microvesicles-as-game-changers-in-better-understanding-the-complexity-of-cellular-interactions-from-bench-to-clinical-applications
#19
REVIEW
Mariusz Z Ratajczak, Janina Ratajczak
Recent research has led to wide acceptance and better understanding of a novel mechanism for cell-cell communication that employs a network of extracellular microvesicles (ExMVs). Derived from the plasma membrane or the endosomal membrane compartment, these small, spherical membrane fragments are secreted from the cell surface or in the process of exocytosis from endosomal membrane compartment and (1) with ligands expressed on their surface directly stimulate target cells in a paracrine manner, (2) transfer cell membrane receptors to target cells or (3) deliver encapsulated messenger RNA, microRNA, proteins and bioactive lipids to target cells...
November 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29147698/molecular-spin-qudits-for-quantum-algorithms
#20
REVIEW
Eufemio Moreno-Pineda, Clément Godfrin, Franck Balestro, Wolfgang Wernsdorfer, Mario Ruben
Presently, one of the most ambitious technological goals is the development of devices working under the laws of quantum mechanics. One prominent target is the quantum computer, which would allow the processing of information at quantum level for purposes not achievable with even the most powerful computer resources. The large-scale implementation of quantum information would be a game changer for current technology, because it would allow unprecedented parallelised computation and secure encryption based on the principles of quantum superposition and entanglement...
November 17, 2017: Chemical Society Reviews
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