keyword
MENU ▼
Read by QxMD icon Read
search

Game changers

keyword
https://www.readbyqxmd.com/read/28815441/pluripotent-stem-cells-in-adult-tissues-struggling-to-be-acknowledged-over-two-decades
#1
REVIEW
Deepa Bhartiya
Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. Besides embryonic stem cells (ES) and induced pluripotent stem cells (iPS), it has been postulated that pluripotent stem cells (PSCs) may also exist in various adult tissues. They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis...
August 16, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28803893/the-companion-dog-as-a-unique-translation-model-for-aging
#2
REVIEW
Andrea Mazzatenta, Camillo Di Giulio, Domenico Robbe, Augusto Carluccio, Alessandro Cellerino
The dog is a unique species due to its wide variation among breeds in size, morphology, behavior and lifespan coupled with a genetic structure that facilitates the dissection of the genetic architecture controlling those traits. Dogs and humans coevolved and share recent evolutionary selection processes like, for example, adaptations to digest starch-rich diets. Many diseases of the dog have a human counterpart, notably Alzheimer's that is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants and are faced with pathogens and infections...
August 10, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28792918/game-changers
#3
Branwen Morgan, Annabel McGilvray
No abstract text is available yet for this article.
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28770513/selective-interleukin-23-p19-inhibition-another-game-changer-in-psoriasis-focus-on-risankizumab
#4
Tiago Torres
The history of psoriasis treatment has been marked by several milestones. Corticosteroids, cyclosporine, tumor necrosis factor alpha (TNF-α) inhibitors and, more recently, interleukin (IL)-17A inhibitors have revolutionized the treatment of psoriasis, each in its own way and time. The IL-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and selective IL-23p19 inhibition may bring several advantages with respect to IL-12/23p40 inhibition, or distal blockade of IL-17A or its receptor...
August 2, 2017: Drugs
https://www.readbyqxmd.com/read/28768387/general-surgery-s-game-changer-and-the-unanswered-question
#5
EDITORIAL
Jonathan B Koea
No abstract text is available yet for this article.
July 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28766054/mri-chest-a-game-changer
#6
REVIEW
Ashu Seith Bhalla, Manisha Jana
No abstract text is available yet for this article.
August 2, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28752001/ultrasound-a-game-changer
#7
EDITORIAL
Wael Saasouh, Alparslan Turan
No abstract text is available yet for this article.
June 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28729242/heading-for-trouble-is-dementia-a-game-changer-for-football
#8
EDITORIAL
A Rutherford, William Stewart, Davide Bruno
No abstract text is available yet for this article.
July 20, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#9
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28723999/moving-towards-south-south-international-health-debts-and-challenges-in-the-regional-health-agenda
#10
María Belén Herrero
The aim of this paper is twofold. First, it aims to investigate the increased interest in health as an important dimension of the foreign policy and diplomatic concerns together with the emergence of a new framework for regional health integration and regional health diplomacy. Second, it seeks to understand the role and practices of new regional blocs in the field of health and whether they are conducting to the emergence of new strategies for addressing health regional policies in South America. The regional policy process relates to health as a right...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28715943/introducing-treat-to-target-strategies-of-autoimmune-extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection
#11
Soledad Retamozo, Pilar Brito-Zerón, Luca Quartuccio, Salvatore De Vita, Manuel Ramos-Casals
The hepatitis C virus (HCV) is recognized as one of the hepatic viruses most often associated with extrahepatic manifestations (EHMs). It is currently accepted that cryoglobulinemic vasculitis (CV) is the key autoimmune extrahepatic disease associated with HCV infection. Therapeutic approaches have mainly been based on the use of old antiviral interferon (IFN)-based regimens and immunosuppressive therapies, often with an inadequate balance between therapeutic benefits and excess side effects. Areas covered: Therapeutic management of HCV patients with EHMs, including both non-autoimmune (cardiovascular, hematological, general features) and autoimmune complications (organ-specific and systemic autoimmune diseases)...
July 27, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28696529/fast-dynamic-visualizations-in-microfluidics-enabled-by-fluorescent-carbon-nanodots
#12
Yi Huang, Lian Xiao, Tingting An, Wenxiang Lim, Teckneng Wong, Handong Sun
Microfluidic systems have become a superior platform for explorations of fascinating fluidic physics at microscale as well as applications in biomedical devices, chemical reactions, drug delivery, etc. Exploitations of this platform are built upon the fundamental techniques of flow visualizations. However, the currently employed fluorescent materials for microfluidic visualization are far from satisfaction, which severely hinders their widespread applications. Here fluorescent carbon nanodots are documented as a game-changer, applicable in versatile fluidic environment for the visualization in microfluidics with unprecedented advantages...
July 11, 2017: Small
https://www.readbyqxmd.com/read/28693853/multidrug-therapy-for-leprosy-a-game-changer-on-the-path-to-elimination
#13
REVIEW
Cairns S Smith, Ann Aerts, Paul Saunderson, Joseph Kawuma, Etsuko Kita, Marcos Virmond
Leprosy is present in more than 100 countries, where it remains a major cause of peripheral neuropathy and disability. Attempts to eliminate the disease have faced various obstacles, including characteristics of the causative bacillus Mycobacterium leprae: the long incubation period, limited knowledge about its mode of transmission, and its poor growth on culture media. Fortunately, the leprosy bacillus is sensitive to several antibiotics. The first antibiotic to be widely used for leprosy treatment was dapsone in the 1950s, which had to be taken over several years and was associated with increasing bacterial resistance...
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28692305/fight-fire-with-fire-gene-therapy-strategies-to-cure-hiv
#14
Jon Huyghe, Sips Magdalena, Linos Vandekerckhove
Human Immunodeficiency Virus (HIV) to date remains one of the most notorious viruses mankind has ever faced. Despite enormous investments in HIV research for more than 30 years an effective cure for HIV has been elusive. Areas covered: Combination antiretroviral therapy (cART) suppresses active viral replication, but is not able to eliminate the virus completely due to stable integration of HIV inside the host genome of infected cells and the establishment of a latent reservoir, that is insensitive to cART...
July 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28677428/support-grows-for-essential-hiv-prevention-drug
#15
Jennifer Trueland
The HIV prevention treatment PrEP has been hailed a game-changer, with the potential to transform people's lives and save the NHS hundreds of thousands of pounds per patient in lifetime costs.
July 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28653006/laparoscopic-liver-resection-for-hepatocellular-carcinoma-in-cirrhotic-patients-a-potential-game-changer-toward-global-standardization-of-care
#16
EDITORIAL
Taizo Hibi, Yuko Kitagawa
No abstract text is available yet for this article.
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28638166/will-real-time-monitoring-technology-be-a-game-changer-for-perfusion-safety
#17
Linda B Mongero
No abstract text is available yet for this article.
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28630366/a-game-changer-for-hereditary-cancer-patients
#18
Brit Cooper-Jones, Katelyn Verstraten
No abstract text is available yet for this article.
June 19, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28611985/adaptation-through-collaboration-developing-novel-platforms-to-advance-the-delivery-of-advanced-therapies-to-patients
#19
REVIEW
Magdalini Papadaki
For the nascent field of advanced therapies, collaboration will be a game-changer, turning scientific progress that was once unimaginable into transformative medical practice. Despite promise for lifelong management and even cure of disease, skepticism remains about the feasibility of their delivery to patients, fueling investment risks. With the potential for long-term effectiveness in need of frequent reassessment, current approaches to predict real-life drug performance bear little relevance, necessitating novel and iterative schemes to monitoring the benefit-risk profiles throughout the life span of advanced therapies...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28601415/brain-autoimmunity-and-intestinal-microbiota-100-trillion-game-changers
#20
REVIEW
Hartmut Wekerle
T cells play a critical role in autoimmune diseases in the brain, particularly in multiple sclerosis (MS). Since T cells are normally prevented from crossing the blood-brain barrier (BBB), autoimmunity requires prior activation of naturally occurring autoreactive T cells in peripheral tissue. Recently, a critical role for the microbiota in this activation process has emerged. Here, we review the role of gut-associated lymphoid tissues (GALT) as a major site for the phenotypic changes that allow the migration of autoreactive T cells to the brain...
July 2017: Trends in Immunology
keyword
keyword
55692
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"