keyword
https://read.qxmd.com/read/38537139/new-races-with-wider-virulence-indicate-rapid-evolution-of-puccinia-striiformis-f-sp-tritici-in-the-southern-cone-of-america
#1
JOURNAL ARTICLE
Venancio Riella, Julian Rodriguez-Algaba, Richard García, Fernando Pereira, Paula Silva, Mogens Støvring Hovmøller, Silvia Elisa Germán
Wheat yellow (stripe) rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the most devastating diseases of wheat worldwide. Pst populations are composed of multiple genetic groups, each carrying one or more races characterized by different avirulence/virulence combinations. Since the severe epidemics in 2017, yellow rust has become the most economically important wheat foliar disease in Uruguay. A set of 124 Pst isolates collected from wheat fields in Uruguay between 2017 and 2021 were characterized phenotypically and 27 of those isolates were subsequently investigated in-depth by additional molecular genotyping and race phenotyping analyses...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537130/comprehensive-molecular-classification-predicted-microenvironment-profiles-and-therapy-response-for-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Yihong Chen, Xiangying Deng, Yin Li, Ying Han, Yinghui Peng, Wantao Wu, Xinwen Wang, Jiayao Ma, Erya Hu, Xin Zhou, Edward Shen, Shan Zeng, Changjing Cai, Yiming Qin, Hong Shen
BACKGROUND AND AIMS: Tumor microenvironment (TME) heterogeneity leads to a discrepancy in survival prognosis and clinical treatment response for hepatocellular carcinoma (HCC) patients. The clinical applications of documented molecular subtypes are constrained by several issues. APPROACH AND RESULTS: We integrated three single-cell datasets to describe the TME landscape and identified six prognosis-related cell subclusters. Unsupervised clustering of subcluster-specific markers was performed to generate transcriptomic subtypes...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537129/the-association-between-mean-arterial-pressure-and-acute-kidney-injury-reversal-among-decompensated-cirrhosis-patients
#3
JOURNAL ARTICLE
Giuseppe Cullaro, Andrew S Allegretti, Cynthia Fenton, Jin Ge, Kavish R Patidar, Jessica Rubin, Arjun Sharma, Jennifer C Lai
BACKGROUND: This study informs how mean arterial pressure (MAP) impacts AKI recovery among all patients hospitalized with cirrhosis, regardless of etiology. METHODS: We identified incident AKI episodes among subjects in our cohort of decompensated cirrhosis patients. AKI was defined as a ≥50% increase in creatinine (sCr) from an outpatient baseline (≥7 days prior) that required hospitalization. Linear mixed-effects models were completed to determine the impact between AKI recovery, MAP, and time...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537061/cost-effectiveness-of-bevacizumab-therapy-in-the-care-of-patients-with-hereditary-hemorrhagic-telangiectasia
#4
JOURNAL ARTICLE
Daniel Wang, Satoko Ito, Christina Waldron, Ayesha Butt, Ellen Zhang, Harlan Krumholz, Hanny Al-Samkari, George Goshua
No FDA or EMA approved therapies exist for bleeding due to hereditary hemorrhagic telangiectasia (HHT), the second-most-common inherited bleeding disorder worldwide. The current standard-of-care (SOC) includes iron and red cell supplementation, alongside the necessary hemostatic procedures, none of which target underlying disease pathogenesis. Recent evidence has demonstrated that bleeding pathophysiology is amenable to systemic antiangiogenic therapy with the anti-VEGF bevacizumab. Despite its high cost, the addition of longitudinal bevacizumab to the current SOC may reduce overall healthcare resource utilization and improve patient quality-of-life...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#5
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38536943/highly-accurate-profiling-of-exosome-phenotypes-using-super-resolution-tricolor-fluorescence-co-localization
#6
JOURNAL ARTICLE
Jinxiu Wei, Kai Zhu, Tingyu Wang, Tongsheng Qi, Zhuyuan Wang, Jia Li, Shenfei Zong, Yiping Cui
Exosomes contain a wealth of proteomic information, presenting promising biomarkers for the noninvasive early diagnosis of diseases, especially cancer. However, it remains a great challenge to accurately and reliably distinguish exosomes secreted from different types of cell lines. Fluorescence immunoassay is frequently used for exosome detection. Nonspecific adsorption in immunoassays is unavoidable and affects the reliability of assay results. Despite the fact that various methods have been proposed to reduce nonspecific adsorption, a more effective method that can eliminate the influence of nonspecific adsorption is still lacking...
March 27, 2024: ACS Nano
https://read.qxmd.com/read/38536935/the-gut-microbiota-posttranslationally-modifies-iga1-in-autoimmune-glomerulonephritis
#7
JOURNAL ARTICLE
Patrick J Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Metallinou, Laureline Berthelot, Jennifer da Silva, Julie Bex-Coudrat, Erwan Boedec, Fanny Canesi, Carine Bounaix, Willy Morelle, Maryse Moya-Nilges, John Kenny, Liam O'Mahony, Loredana Saveanu, Bertrand Arnulf, Aurélie Sannier, Eric Daugas, François Vrtovsnik, Patricia Lepage, Harry Sokol, Renato C Monteiro
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading to glomerulonephritis. In the intestinal microbiota of patients with IgA nephropathy, there was increased relative abundance of mucin-degrading bacteria, including Akkermansia muciniphila ...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536880/bias-in-the-arrival-of-variation-can-dominate-over-natural-selection-in-richard-dawkins-s-biomorphs
#8
JOURNAL ARTICLE
Nora S Martin, Chico Q Camargo, Ard A Louis
Biomorphs, Richard Dawkins's iconic model of morphological evolution, are traditionally used to demonstrate the power of natural selection to generate biological order from random mutations. Here we show that biomorphs can also be used to illustrate how developmental bias shapes adaptive evolutionary outcomes. In particular, we find that biomorphs exhibit phenotype bias, a type of developmental bias where certain phenotypes can be many orders of magnitude more likely than others to appear through random mutations...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38536866/diagnostic-findings-and-yield-of-investigations-for-children-with-developmental-regression
#9
JOURNAL ARTICLE
Kirsten Furley, Matthew F Hunter, Michael Fahey, Katrina Williams
Childhood conditions that feature developmental regression are poorly understood. Phenotype-genotype characterization and diagnostic yield data are needed to inform clinical decision-making. The aim of this study was to report the conditions featuring developmental regression and assess diagnostic yields of investigations. A retrospective chart review of children presenting with developmental regression to a tertiary pediatric genetic clinic between 2018 and 2021 was performed. Of 99 children, 30% (n = 30) had intellectual disability (ID), 21% (n = 21) were autistic, 39% (n = 39) were autistic with ID, and 9% (n = 9) did not have ID or autism...
March 27, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38536817/rpgr-is-a-guanine-nucleotide-exchange-factor-for-the-small-gtpase-rab37-required-for-retinal-function-via-autophagy-regulation
#10
JOURNAL ARTICLE
Ruhong Ying, Cong Li, Huirong Li, Juan Zou, Mengxin Hu, Qiang Hong, Yin Shen, Ling Hou, Hanhua Cheng, Rongjia Zhou
Although the small GTPase RAB37 acts as an organizer of autophagosome biogenesis, the upstream regulatory mechanism of autophagy via guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange in maintaining retinal function has not been determined. We found that retinitis pigmentosa GTPase regulator (RPGR) is a guanine nucleotide exchange factor that activates RAB37 by accelerating GDP-to-GTP exchange. RPGR directly interacts with RAB37 via the RPGR-RCC1-like domain to promote autophagy through stimulating exchange...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536703/dietary-galacto-oligosaccharides-ameliorate-atopic-dermatitis-like-skin-inflammation-and-behavioral-deficits-by-modulating-gut-microbiota-brain-skin-axis
#11
JOURNAL ARTICLE
Liu Tang, Xiaoqin Cao, Shaoze Chen, Xiao Jiang, Dan Li, Guanghui Chen
Atopic dermatitis (AD), a chronic, highly pruritic, and inflammatory skin disorder, often coexists with psychiatric comorbidities including anxiety and depression, posing considerable challenges for treatment. The current research aims at evaluating the efficacy and potential therapeutic mechanism of galacto-oligosaccharides (GOS) on AD-like skin lesions and comorbid anxiety/depressive disorders. Macroscopical and histopathological examination showed that GOS could markedly relieve skin inflammation by decreasing the production of IgE, IL-4, IL-13, IFN-γ, and TNF-α and regulating the PPAR-γ/NF-κB signaling in DNFB-induced AD mice...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38536645/recent-advances-in-understanding-the-biology-of-follicular-lymphoma
#12
REVIEW
Momoko Nishikori
Follicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt disease. BCL2 overexpression by t(14;18) confers a survival advantage to B cells during the germinal center reaction, and abnormalities in epigenetic modifier genes lead to desynchronization of gene expression changes in germinal center B cells. Studies in mouse models have shown that BCL2 overexpression and epigenetic deregulation in B cells cooperatively promote lymphomagenesis. The immune microenvironment also plays an essential role in the biology of FL, and many molecular prognostic indicators based on the immune microenvironment have been proposed...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38536595/identification-novel-mutations-and-phenotypic-spectrum-expanding-in-patl2-in-infertile-women-with-ivf-icsi-failure
#13
JOURNAL ARTICLE
Zhiqi Ye, Da Li, Xiangli Niu, Aimin Yang, Zhiqi Pan, Ran Yu, Hao Gu, Rong Shi, Ling Wu, Yanfang Xiang, Guimin Hao, Yanping Kuang, Biaobang Chen, Lei Wang, Qing Sang, Lin Li, Juanzi Shi, Qiaoli Li
AIM: Abnormalities in oocyte maturation, fertilization, and early embryonic development are major causes of primary infertility in women who are undergoing IVF/ICSI attempts. Although many genetic factors responsible for these abnormal phenotypes have been identified, there are more additional pathogenic genes and variants yet to be discovered. Previous studies confirmed that bi-allelic PATL2 deficiency is an important factor for female infertility. In this study, 935 infertile patients with IVF/ICSI failure were selected for whole-exome sequencing, and 18 probands carrying PATL2 variants with a recessive inheritance pattern were identified...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536555/folate-induces-stemness-and-increases-oxygen-consumption-under-glucose-deprivation-by-notch-1-pathway-activation-in-colorectal-cancer-cell
#14
JOURNAL ARTICLE
Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
Evidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies...
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38536522/composition-of-the-rumen-microbiome-and-its-association-with-methane-yield-in-dairy-cattle-raised-in-tropical-conditions
#15
JOURNAL ARTICLE
Priscila Fregulia, Roberto Júnio Pedroso Dias, Mariana Magalhães Campos, Thierry Ribeiro Tomich, Luiz Gustavo Ribeiro Pereira, André Luis Alves Neves
BACKGROUND: Methane (CH4 ) emissions from rumen fermentation are a significant contributor to global warming. Cattle with high CH4 emissions tend to exhibit lower efficiency in milk and meat production, as CH4 production represents a loss of the gross energy ingested by the animal. The objective of this study was to investigate the taxonomic and functional composition of the rumen microbiome associated with methane yield phenotype in dairy cattle raised in tropical areas. METHODS AND RESULTS: Twenty-two Girolando (F1 Holstein x Gyr) heifers were classified based on their methane yield (g CH4 / kg dry matter intake (DMI)) as High CH4 yield and Low CH4 yield...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536457/sbys1-and-sbwrky72-regulate-cd-tolerance-and-accumulation-in-sweet-sorghum
#16
JOURNAL ARTICLE
Weitao Jia, Zijing Guo, Sulian Lv, Kangqi Lin, Yinxin Li
SbYS1 and its upstream transcription factor SbWRKY72 were involved in Cd tolerance and accumulation and are valuable for developing sweet sorghum germplasm with high-Cd tolerance or accumulation ability through genetic manipulation. Cadmium (Cd) is highly toxic and can severely affect human health. Sweet sorghum, as an energy crop, shows great potential in extracting cadmium from Cd-contaminated soils. However, its molecular mechanisms of Cd-tolerance and -accumulation remain largely unknown. Here, we isolated a YSL family gene SbYS1 from the sweet sorghum genotype with high Cd accumulation ability and the expression of SbYS1 in roots was induced by cadmium...
March 27, 2024: Planta
https://read.qxmd.com/read/38536434/the-analysis-of-boric-acid-effect-on-epithelial-mesenchymal-transition-of-cd133%C3%A2-%C3%A2-cd117%C3%A2-%C3%A2-lung-cancer-stem-cells
#17
JOURNAL ARTICLE
Tuğba Semerci Sevimli, Murat Sevimli, Aynaz Ghorbani, Varol Şahintürk, Emilia Qomi Ekenel, Tuğba Ertem, Bahar Demir Cevizlidere, Burcugül Altuğ, Özlem Tomsuk, Onur Uysal, Sibel Güneş Bağış, Hüseyin Avci, Fatih Çemrek, Zarifa Ahmadova
Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against lung cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using the magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect of BA was measured by MTT analysis, and the effect of BA on EMT was examined by migration analysis. The expression levels of ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM, COL1A1, and LAMA5 genes were analyzed by RT-qPCR...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536220/benchmarking-mental-health-status-using-passive-sensor-data-protocol-for-a-prospective-observational-study
#18
JOURNAL ARTICLE
Robyn E Kilshaw, Abigail Boggins, Olivia Everett, Emma Butner, Feea R Leifker, Brian R W Baucom
BACKGROUND: Computational psychiatry has the potential to advance the diagnosis, mechanistic understanding, and treatment of mental health conditions. Promising results from clinical samples have led to calls to extend these methods to mental health risk assessment in the general public; however, data typically used with clinical samples are neither available nor scalable for research in the general population. Digital phenotyping addresses this by capitalizing on the multimodal and widely available data created by sensors embedded in personal digital devices (eg, smartphones) and is a promising approach to extending computational psychiatry methods to improve mental health risk assessment in the general population...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536209/-pseudomonas-hefeiensis-sp-nov-isolated-from-the-rhizosphere-of-multiple-cash-crops-in-china
#19
JOURNAL ARTICLE
Kaiji Liao, Qiang Li, Jun-Zhou Li, Hai-Lei Wei
Three bacterial strains, FP250T , FP821, and FP53, were isolated from the rhizosphere soil of oilseed rape, licorice, and habanero pepper in Anhui Province, Xinjiang Uygur Autonomous Region, and Jiangsu Province, PR China, respectively. All strains were shown to grow at 4-37 °C and pH 6.0-9.0, and in the presence of 0-4.0 % (w/v) NaCl. Phylogenetic analyses based on 16S rRNA gene sequences or housekeeping genes (16S rRNA, gyrB , rpoB , and rpoD ) and phylogenomic analysis showed that strains FP250T , FP821, and FP53 belong to the genus Pseudomonas , and are closely related to Pseudomonas kilonensis DSM 13647T , Pseudomonas brassicacearum JCM 11938T , Pseudomonas viciae 11K1T , and Pseudomonas thivervalensis DSM 13194T ...
March 2024: International Journal of Systematic and Evolutionary Microbiology
https://read.qxmd.com/read/38536200/incidence-risk-factors-and-outcome-of-asymptomatic-central-nervous-system-involvement-in-adult-patients-with-acute-myeloid-leukemia
#20
JOURNAL ARTICLE
Marijana Virijevic, Nada Kraguljac-Kurtovic, Mirjana Mitrovic, Ljubomir Jakovic, Zoran Bukumuric, Nikola Pantic, Nikica Sabljic, Zlatko Pravdic, Mirjana Cvetkovic, Vesna Knezevic, Tijana Dragovic-Ivancevic, Irena Djunić, Jovan Rajic, Violeta Milosevic, Milena Todorovic-Balint, Ana Vidovic, Nada Suvajdzic-Vukovic
Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic patients with CNS involvement might go undetected. The effect of CNS involvement on the AML disease course is not well defined, with conflicting results regarding clinical outcome. This study aimed to determine the incidence of asymptomatic CNS involvement in AML estimated by multiparametric flow cytometry of cerebrospinal fluid (MFC-CSF) at diagnosis, the related potential risk factors, and prognosis...
March 2024: Hematological Oncology
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