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https://www.readbyqxmd.com/read/29906786/ct-features-of-her2-mutant-lung-adenocarcinomas
#1
REVIEW
Peter Sawan, Andrew J Plodkowski, Angela E Li, Bob T Li, Alexander Drilon, Marinela Capanu, Michelle S Ginsberg
OBJECTIVES: To describe the radiological phenotype of HER2-mutant lung cancers on CT at presentation. METHODS: Eligible patients with lung adenocarcinomas with HER2 mutations were stage-matched with two control groups (EGFR- and KRAS-mutant groups). Evaluated CT features of the primary tumor included size, location, consistency, contour, presence of pleural tags and pleural retractions. Presence of pleural effusions, lung metastases, adenopathy, chest wall invasion, and were also recorded...
June 7, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29906750/naringenin-attenuates-behavioral-derangements-induced-by-social-defeat-stress-in-mice-via-inhibition-of-acetylcholinesterase-activity-oxidative-stress-and-release-of-pro-inflammatory-cytokines
#2
Solomon Umukoro, Hassanat Adeola Kalejaye, Benneth Ben-Azu, Abayomi M Ajayi
The effects of naringenin; a dietary flavonoid, with potent anti-oxidant and anti-inflammatory activities on social defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using resident-intruder paradigm. The intruder male mice were distributed into 6 groups (n = 6). Mice in group 1 (control) received vehicle (3% DMSO, i.p), group 2 (SDS-control) were also given vehicle, groups 3-5 received naringenin (10, 25 and 50 mg/kg, i.p.) while group 6 had ginseng (50 mg/kg, i...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906748/transient-receptor-potential-vanilloid-type-2-targeting-on-stemness-in-liver-cancer
#3
Zecheng Hu, Xiaocheng Cao, Yu Fang, Guoxing Liu, Chengzhi Xie, Ke Qian, Xiaohua Lei, Zhenyu Cao, Huihui Du, Xiangding Cheng, Xundi Xu
The malignant phenotype of the cells resulting from human liver cancer is driven by liver cancer stem-like cells (LCSLCs). Transient Receptor Potential Vanilloid-type 2 channel (TRPV2) contributes to the progression of different tumor types, including liver cancer. In the current study, the TRPV2 expression levels give rise to the effect on stemness in liver cancer cell lines. TRPV2 knockdown in HepG2 cells enhanced spheroid and colony formation, and expression levels of CD133, CD44 and ALDH1 whereas the opposite effects were observed in TRPV2 enforced expression in SMMC-7721 cells...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906696/ictal-signs-in-tuberous-sclerosis-complex-clinical-and-video-eeg-features-in-a-large-series-of-recorded-seizures
#4
Miriam Nella Savini, Alessia Mingarelli, Aglaia Vignoli, Francesca La Briola, Valentina Chiesa, Angela Peron, Roberto Mai, Laura Tassi, Massimo Mastrangelo, Elena Zambrelli, Katherine Turner, Maria Paola Canevini
Epilepsy is the most common neurological symptom in tuberous sclerosis complex (TSC), occurring in 72-85% of affected individuals. Despite the large number of patients reported, their electroclinical phenotype has been rarely described. We analyzed seizure semiology through ictal video-electroencephalography (V-EEG) recordings in a large series of patients. In this multicenter study, we reviewed V-EEGs of 51 patients: ictal recordings were analyzed in correlation with their clinical variables. The median age of epilepsy onset was six months (one day-16 years), with onset in the first year of life in 71% patients (36/51), in 10 of them during the neonatal period...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906695/influence-of-ph-on-the-uptake-and-toxicity-of-%C3%AE-blockers-in-embryos-of-zebrafish-danio-rerio
#5
Lisa Bittner, Elisabet Teixido, Bettina Seiwert, Beate I Escher, Nils Klüver
ß-Blockers are weak bases with acidity constants related to their secondary amine group. At environmental pH they are protonated with the tendency to shift to their neutral species at more alkaline pH. Here we studied the influence of pH from 5.5 to 8.6 on the toxicity of the four ß-blockers atenolol, metoprolol, labetalol and propranolol in zebrafish embryos, relating toxicity not only in a conventional way to external aqueous concentrations but also to measured internal concentrations. Besides lethality, we evaluated changes in swimming activity and heartbeat, using the Locomotor Response (LMR) method and the Vertebrate Automated Screening Technology (VAST) for high throughput imaging...
May 28, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29906629/shorter-sleep-duration-is-associated-with-reduced-cognitive-development-at-two-years-of-age
#6
Lisa Smithson, Tieghan Baird, Sukhpreet K Tamana, Amanda Lau, Jennifer Mariasine, Joyce Chikuma, Diana L Lefebvre, Padmaja Subbarao, Allan B Becker, Stuart E Turvey, Malcolm R Sears, Deryk S Beal, Jacqueline Pei, Piush J Mandhane
BACKGROUND: Both short sleep duration and sleep-disordered breathing (SDB) are associated with poor neurocognitive development. However, the co-contributions of short sleep duration and SDB on neurodevelopment in pre-school children are relatively unknown. METHODS: We assessed both sleep duration and SDB by quarterly questionnaire from three months to two years of age among Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort participants. Group-based modeling determined trajectories of total, daytime, and nighttime sleep duration and SDB...
April 30, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29906612/nad-and-sirtuins-in-retinal-degenerative-diseases-a-look-at-future-therapies
#7
REVIEW
Jonathan B Lin, Rajendra S Apte
Retinal degenerative diseases are a major cause of morbidity in modern society because visual impairment significantly decreases the quality of life of patients. A significant challenge in treating retinal degenerative diseases is their genetic and phenotypic heterogeneity. However, despite this diversity, many of these diseases share a common endpoint involving death of light-sensitive photoreceptors. Identifying common pathogenic mechanisms that contribute to photoreceptor death in these diverse diseases may lead to a unifying therapy for multiple retinal diseases that would be highly innovative and address a great clinical need...
June 12, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29906586/characterization-of-monocyte-subtypes-regarding-their-phenotype-and-development-in-the-context-of-graft-versus-host-disease
#8
Katharina Reinhardt-Heller, Insa Hirschberg, Thomas Vogl, Rupert Handgretinger, Ursula Holzer
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). In this study, monocyte subtypes were characterized regarding cytokine expression pattern and development in the context of GvHD. Using inflammatory S100 proteins for monocyte stimulation, it could be demonstrated that intermediate monocytes are the main producers of inflammatory cytokines such as IL-6 and TNFα known to be involved in the development of Th17 cells pointing towards an inflammatory phenotype of this monocyte subtype...
June 12, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29906569/salival-%C3%AE-iduronidase-activity-as-a-potential-new-biomarker-for-the-diagnosis-and-monitoring-the-effect-of-therapy-in-mucopolysaccharidosis-i
#9
Jaap van Doorn, Brigitte T A van den Broek, Ans J Geboers, Gé-Ann Kuiper, J J Boelens, Peter M van Hasselt
Although disease progression in Mucopolysaccharidosis I (MPS-1) can be attenuated by hematopoietic cell transplantation (HCT), it is increasingly recognized that residual disease is substantial. Biomarkers that would allow us to evaluate the efficacy of HCT (and upcoming new therapies) in non-hematological tissues are needed. Current biomarkers, including the iduronidase (IDUA) activity in leukocytes, are not suitable for this purpose as they are assessed in tissues of hematological origin and may not reflect enzyme availability in non-hematologic tissues...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29906552/interleukin-33-protects-ischemic-brain-injury-by-regulating-specific-microglial-activities
#10
Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin, Qi Chen
Interleukin-33 (IL-33), a novel member of the IL-1 family, expressed in many tissue and cell types, and is involved in inflammation and immune functions. Previous studies suggest that IL-33 may play a role in ischemic stroke. We tried to investigate the role of IL-33 in cerebral ischemia-reperfusion-induced injury and its underlying mechanism. Our data indicated that IL-33 deficiency exacerbated the neurological dysfunction caused by cerebral ischemia-reperfusion injury in mice and led to the formation of larger cerebral infarct volume as shown by 2,3,5-triphenyltetrazolium chloride (TTC) staining and magnetic resonance imaging...
June 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29906528/cd300c-co-stimulates-ige-mediated-basophils-activation-and-its-expression-is-increased-in-cow%C3%A2-s-milk-allergy
#11
Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Ane Orrantia, Itziar Astigarraga, Leire Dopazo, Carlos Gonzalez, Laura Santos-Díez, Carlos Tutau, Pedro M Gamboa, Agurtzane Bilbao, Francisco Borrego
BACKGROUND: Basophils express high-affinity IgE receptors (FcεRI), which play an essential role in allergic diseases. To design promising immunomodulatory therapies, it is important to characterize new cell surface receptors that modulate immunoglobulin (Ig)E-mediated basophil activation threshold. OBJECTIVES: To analyze the expression of CD300 receptors on human basophils and their implication in IgE-mediated basophil activation processes. METHODS: Blood samples from healthy and cow´s milk allergic patients were collected through the Basque Biobank under an institutional review board-approved protocol...
June 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29906504/adaptive-laboratory-evolution-resolves-energy-depletion-to-maintain-high-aromatic-metabolite-phenotypes-in-escherichia-coli-strains-lacking-the-phosphotransferase-system
#12
Douglas McCloskey, Sibei Xu, Troy E Sandberg, Elizabeth Brunk, Ying Hefner, Richard Szubin, Adam M Feist, Bernhard O Palsson
Aromatic metabolites provide the backbone for numerous industrial and pharmaceutical compounds of high value. The Phosphotransferase System (PTS) is common to many bacteria, and is the primary mechanism for glucose uptake by Escherichia coli. The PTS was removed to conserve phosphoenolpyruvate (pep), which is a precursor for aromatic metabolites and consumed by the PTS, for aromatic metabolite production. Replicate adaptive laboratory evolution (ALE) of PTS and detailed omics data sets collected revealed that the PTS bridged the gap between respiration and fermentation, leading to distinct high fermentative and high respiratory rate phenotypes...
June 12, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29906448/genomic-dissection-of-bipolar-disorder-and-schizophrenia-including-28-subphenotypes
#13
(no author information available yet)
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders...
June 14, 2018: Cell
https://www.readbyqxmd.com/read/29906443/disease-heritability-studies-harness-the-healthcare-system-to-achieve-massive-scale
#14
Joshua C Denny, Jonathan D Mosley
Heritability studies are essential for defining genetic influences on disease risk and trait variability. Polubriaginof et al. show how massive amounts of data contained in electronic health records can be used for heritability studies on hundreds of phenotypes. Mining emergency contact information with comparison to existing gold standards showcases the broad utility of the approach.
June 14, 2018: Cell
https://www.readbyqxmd.com/read/29906423/the-accumulation-of-enzymatically-inactive-cuproenzymes-is-a-cns-specific-phenomenon-of-the-sod1-g37r-mouse-model-of-als-and-can-be-restored-by-overexpressing-the-human-copper-transporter-hctr1
#15
James B Hilton, Kai Kysenius, Anthony R White, Peter J Crouch
Mutations to the copper-dependent enzyme Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans, and transgenic overexpression of mutant SOD1 represents a robust murine model of the disease. We have previously shown that the copper-containing compound CuII (atsm) phenotypically improves mutant SOD1 mice and delivers copper to copper-deficient SOD1 in the CNS to restore its physiological function. CuII (atsm) is now in clinical trials for the treatment of ALS. In this study, we demonstrate that cuproenzyme dysfunction extends beyond SOD1 in SOD1G37R mice to also affect the endogenous copper-dependent ferroxidase ceruloplasmin...
June 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29906411/dermal-fibroblast-slc3a2-deficiency-leads-to-premature-aging-and-loss-of-epithelial-homeostasis
#16
Floriane S Tissot, Soline Estrach, Etienne Boulter, Laurence Cailleteau, Lionel Tosello, Laetitia Seguin, Sabrina Pisano, Stéphane Audebert, Olivier Croce, Chloé C Féral
Skin homeostasis relies on fine tuning of epidermis/dermis interactions and is affected by aging. While extracellular matrix (ECM) proteins, such as integrins, are involved in aging, the molecular basis of the skin changes need to be further investigated. Here, we showed that integrin co-receptor, SLC3A2, required for cell proliferation, is expressed at the surface of resting dermal fibroblasts (DF) in young patients, and drastically reduced with aging. In vivo SLC3A2 DF deletion induced major skin phenotypes resembling premature aging...
June 12, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29906313/the-distribution-of-intratumoral-macrophages-correlates-with-molecular-phenotypes-and-impacts-prognosis-in-colorectal-carcinoma
#17
Younghoon Kim, Xianyu Wen, Jeong Mo Bae, Jung Ho Kim, Nam-Yun Cho, Gyeong Hoon Kang
The role of tumor-associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumor-infiltrating lymphocytes (TILs), and prognosis in CRC via image analysis. Immunohistochemical staining for CD68 and CD163 was performed with pan-macrophage and M2-macrophage markers, respectively. Each marker was separately analyzed for intraepithelial and stromal area densities. All four macrophage densities showed a significant correlation with one another (p = 0...
June 15, 2018: Histopathology
https://www.readbyqxmd.com/read/29906301/genetic-dissection-of-pre-anthesis-sub-phase-durations-during-the-reproductive-spike-development-of-wheat
#18
Zifeng Guo, Dijun Chen, Marion Roeder, Martin Ganal, Thorsten Schnurbusch
Flowering time is an important factor affecting grain yield in wheat. In this study, we divided reproductive spike development into eight sub-phases. These sub-phases have the potential to be delicately manipulated to increase grain yield. We measured 36 traits with regard to sub-phase durations, determined three grain yield-related traits in eight field environments and mapped 15,696 single nucleotide polymorphism (SNP, based on 90k Infinium chip and 35k Affymetrix chip) markers in 210 wheat genotypes. Phenotypic and genetic associations between grain yield traits and sub-phase durations show significant consistency (Mantel test r = 0...
June 15, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29906288/a-mfs-like-plasma-membrane-transporter-required-for-leishmania-virulence-protects-the-parasites-from-iron-toxicity
#19
Maria Fernanda Laranjeira-Silva, Wanpeng Wang, Tamika K Samuel, Fernando Y Maeda, Vladimir Michailowsky, Iqbal Hamza, Zhongchi Liu, Norma W Andrews
Iron is essential for many cellular processes, but can generate highly toxic hydroxyl radicals in the presence of oxygen. Therefore, intracellular iron accumulation must be tightly regulated, by balancing uptake with storage or export. Iron uptake in Leishmania is mediated by the coordinated action of two plasma membrane proteins, the ferric iron reductase LFR1 and the ferrous iron transporter LIT1. However, how these parasites regulate their cytosolic iron concentration to prevent toxicity remains unknown...
June 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29906261/a-complete-high-quality-minion-nanopore-assembly-of-an-extensively-drug-resistant-mycobacterium-tuberculosis-beijing-lineage-strain-identifies-novel-variation-in-repetitive-pe-ppe-gene-regions
#20
Arnold Bainomugisa, Tania Duarte, Evelyn Lavu, Sushil Pandey, Chris Coulter, Ben J Marais, Lachlan M Coin
A better understanding of the genomic changes that facilitate the emergence and spread of drug-resistant Mycobacterium tuberculosis strains is currently required. Here, we report the use of the MinION nanopore sequencer (Oxford Nanopore Technologies) to sequence and assemble an extensively drug-resistant (XDR) isolate, which is part of a modern Beijing sub-lineage strain, prevalent in Western Province, Papua New Guinea. Using 238-fold coverage obtained from a single flow-cell, de novo assembly of nanopore reads resulted into one contiguous assembly with 99...
June 15, 2018: Microbial Genomics
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