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JOURNAL ARTICLE
Shimels Tesfaye, Fikru Regassa, Gashaw Beyene, Samson Leta, Jan Paeshuyse
INTRODUCTION: Lumpy skin disease is a viral disease that affects cattle belonging to genus Capripoxvirus (Poxviridae) and lead to significant economic losses. OBJECTIVE: The objective of this study was to evaluate the distribution of lumpy skin disease (LSD) outbreaks and predict future patterns based on retrospective outbreak reports in Ethiopia. METHODS: Data were collected through direct communication with regional laboratories and a hierarchical reporting system from the Peasant Associations to Ministry of Agriculture...
2024: Frontiers in Veterinary Science
#22
JOURNAL ARTICLE
Peter Ruzanov, Valentina Evdokimova, Manideep C Pachva, Alon Minkovich, Zhenbo Zhang, Sofya Langman, Hendrik Gassmann, Uwe Thiel, Marija Orlic-Milacic, Syed H Zaidi, Vanya Peltekova, Lawrence E Heisler, Manju Sharma, Michael E Cox, Trevor D McKee, Mark Zaidi, Eve Lapouble, John D McPherson, Olivier Delattre, Laszlo Radvanyi, Stefan Eg Burdach, Lincoln D Stein, Poul H Sorensen
Aberrant expression of ETS transcription factors characterizes numerous human malignancies. Many of these proteins, including EWS::FLI1 and EWS::ERG fusions in Ewing sarcoma (EwS) and TMPRSS2::ERG in prostate cancer (PCa), drive oncogenic programs via binding to GGAA repeats. We report here that both EWS::FLI1 and ERG bind and transcriptionally activate GGAA-rich pericentromeric heterochromatin. The respective pathogen-like HSAT2 and HSAT3 RNAs, together with LINE, SINE, ERV and other repeat transcripts, are expressed in EwS and PCa tumors, secreted in extracellular vesicles (EVs) and are highly elevated in plasma of EwS patients with metastatic disease...
March 26, 2024: Journal of Clinical Investigation
#23
JOURNAL ARTICLE
Ai Van Thuy Ho, Eirik Øvensen, Didrik Lilja, Karin Toska, Odd Grenager, Knut Kristiansen, Jarlis Wesche
OBJECTIVES: The aim of this study was to assess the potential of electrodermal activity (EDA) as a diagnostic tool for preoperative evaluation in hyperhidrosis patients. EDA levels and patterns in different skin areas were investigated before and after endoscopic thoracic sympathicotomy (ETS) and was compared to healthy subjects. METHODS: Thirty-seven patients underwent two days of measurements before and after the operation. Twenty-five (67.5%) of the patients also had a third measurement after six months...
2024: Frontiers in Surgery
#24
JOURNAL ARTICLE
Dalia Rosano, Emre Sofyali, Heena Dhiman, Chiara Ghirardi, Diana Ivanoiu, Timon Heide, Andrea Vingiani, Alessia Bertolotti, Giancarlo Pruneri, Eleonora Canale, Hannah F Dewhurst, Debjani Saha, Neil Slaven, Iros Barozzi, Tong Li, Grigory Zemlyanskiy, Henry Phillips, Chela James, Balázs Győrffy, Claire Lynn, George D Cresswell, Farah Rehman, Roberta Noberini, Tiziana Bonaldi, Andrea Sottoriva, Luca Magnani
UNLABELLED: Patients with estrogen receptor-positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients relapse even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late relapse patients and longitudinally profiled a rare cohort treated with long-term neoadjuvant ETs until progression...
March 21, 2024: Cancer Discovery
#25
JOURNAL ARTICLE
Suleva Povea-Cabello, Michele Brischigliaro, Erika Fernández-Vizarra
In eukaryotic cells, mitochondria perform cellular respiration through a series of redox reactions ultimately reducing molecular oxygen to water. The system responsible for this process is the respiratory chain or electron transport system (ETS) composed of complexes I-IV. Due to its function, the ETS is the main source of reactive oxygen species (ROS), generating them on both sides of the mitochondrial inner membrane, i.e. the intermembrane space (IMS) and the matrix. A correct balance between ROS generation and scavenging is important for keeping the cellular redox homeostasis and other important aspects of cellular physiology...
March 25, 2024: Biochemical Society Transactions
#26
JOURNAL ARTICLE
Liang Peng, Xiaohan Luo, Baodi Cao, Xiaohui Wang
PURPOSE: The detrimental effects of environmental tobacco smoke (ETS) on women's reproductive health have been widely recognized. However, the detailed association between exposure to environmental tobacco smoke and the incidence of infertility remains under-explored. This investigation focuses on exploring this potential connection. METHODS: For this analysis, we extracted data from the US National Health and Nutrition Examination Survey (NHANES) database, covering the years 2013 to 2018, focusing on individuals with recorded serum cotinine levels and infertility information...
2024: Frontiers in Public Health
#27
JOURNAL ARTICLE
Kristin Van Heertum, Elizabeth A DeVilbiss, James Goldfarb, Sunni L Mumford, Rachel Weinerman
OBJECTIVE: To compare neonatal outcomes in pregnancies resulting from embryos that have undergone preimplantation genetic testing (PGT) biopsy compared with no biopsy in both fresh and frozen embryo transfers (ETs) and determine whether findings are mediated by multiple births. DESIGN: Retrospective cohort study. SETTING: Society of Assisted Reproductive Technologies-Clinical Outcomes Reporting System data, 2014-2015. PATIENTS: Autologous in vitro fertilization treatment cycles using fresh or frozen blastocyst ET, with or without PGT biopsy...
March 2024: F&S reports
#28
JOURNAL ARTICLE
Partho Sen, Yong Fan, Jennifer J Schlezinger, Stanislav D Ehrlich, Thomas F Webster, Tuulia Hyötyläinen, Oluf Pedersen, Matej Orešič
Environmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs are linked with obesity and insulin resistance partly through a dysbiotic gut microbiota and changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- and polyfluoroalkyl substances (PFAS) and additional twenty-seven ETs were measured by mass spectrometry in 264 Danes (121 men and 143 women, aged 56.6 ± 7.3 years, BMI 29.7 ± 6.0 kg/m2 ) using a combination of targeted and suspect screening approaches...
March 20, 2024: Environment International
#29
JOURNAL ARTICLE
Hang Jiang, Zhiqian Xue, Liping Zhao, Boyuan Wang, Chenfei Wang, Haihan Song, Jianjun Sun
Pancreatic adenocarcinoma (PAAD) is a notably aggressive malignancy with limited treatment options and an unfavorable prognosis for patients. We aimed to investigate molecular mechanisms by which Sam's pointed domain-containing ETS transcription factor (SPDEF) exerts effects on PAAD progression. We analyzed differentially expressed genes (DEGs) and their integration with ETS family members using the The Cancer Genome Atlas (TCGA) database, hence identifying SPDEF as a core gene in PAAD. Kaplan-Meier survival analysis confirmed SPDEF's prognostic potential...
March 23, 2024: Biomol Biomed
#30
JOURNAL ARTICLE
Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study.
Xingyu Wang, Xin Liu, Martin J O'Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Hongye Zhang, Lisheng Liu, Prem Pais, Patricio Lopez-Jaramillo, Albertino Damasceno, Peter Langhorne, Annika Rosengren, Antonio L Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Conor Judge, Hans-Christoph Diener, Danuta Ryglewicz, Anna Czlonkowska, Nana Pogosova, Christian Weimar, Romana Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Aytekin Oguz, Ernesto Penaherrera, Fernando Lanas, Okechukwu S Ogah, A Ogunniyi, Helle K Iversen, German Malaga, Zvonko Rumboldt, Shahram Oveisgharan, Fawaz Al Hussain, Yongchai Nilanont, Salim Yusuf
BACKGROUND: Smoking is a major risk factor for the global burden of stroke. We have previously reported a global population attributable risk (PAR) of stroke of 12.4% associated with current smoking. In this study we aimed to explore the association of current tobacco use with different types of tobacco exposure and environmental tobacco smoke (ETS) exposure on the risk of stroke and stroke subtypes, and by regions and country income levels. METHODS: The INTERSTROKE study is a case-control study of acute first stroke and was undertaken with 13,462 stroke cases and 13,488 controls recruited between January 11, 2007 and August 8, 2015 in 32 countries worldwide...
April 2024: EClinicalMedicine
#31
JOURNAL ARTICLE
Ilaria Aurigemma, Olga Lanzetta, Andrea Cirino, Sara Allegretti, Gabriella Lania, Rosa Ferrentino, Varsha Poondi Krishnan, Claudia Angelini, Elizabeth Illingworth, Antonio Baldini
Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal mesoderm, which gives rise also to cardiac and branchiomeric muscles. The enhancers activated during endothelial differentiation within the cardiopharyngeal mesoderm are not completely known. Here, we use a cardiogenic mesoderm differentiation model that activates an endothelial transcription program to identify endothelial regulatory elements activated in early cardiogenic mesoderm. Integrating chromatin remodeling and gene expression data with available single-cell RNA-seq data from mouse embryos, we identify 101 putative regulatory elements of EC genes...
March 21, 2024: Communications Biology
#32
Adil Aziz Khan, Sana Ahuja, Sufian Zaheer, Sumanta Das
Epithelioid hemangioma also known as angio-lymphoid hyperplasia with eosinophilia is a rare benign vascular neoplasm of unknown etiology. It very rarely involves the nasal cavity. It always poses a diagnostic challenge for clinicians and is usually misdiagnosed as Kimura's, IgG4-related disease, or malignant vascular tumors. The present case report describes an extremely rare presentation of epithelioid hemangioma inside the left nasal cavity causing complete obstruction and nasal septal deviation towards the right side in a young male...
March 2024: Indian Journal of Surgical Oncology
#33
JOURNAL ARTICLE
Rahil Singh, Anju Romina Bhalotra, Shubhangi Sharma
BACKGROUND: Endotracheal suctioning (ETS) is one of the most frequently performed invasive procedures in intensive care units (ICUs). This audit was aimed at studying current practices and knowledge regarding ETS in the Indian critical care setup, with the background aim of raising awareness regarding correct practices as per current recommendations in critically ill patients. MATERIALS AND METHODS: After registering the trial with the clinical trial registry, India, a structured audit questionnaire containing 20 questions pertaining to ETS was distributed through electronic media among resident doctors working in the ICUs across India...
January 2024: Indian Journal of Critical Care Medicine
#34
JOURNAL ARTICLE
Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology related to lung fibrosis, whereas the mechanism that ETS exposure augments pulmonary fibrogenesis is unclear. We hypothesized that ETS exposure could exacerbate fibrotic responses via collagen dynamic dysregulation and complement activation. C57BL/6J and p16-3MR mice were exposed to ETS followed by bleomycin administration. ETS exposure exacerbated bleomycin-induced collagen and lysyl oxidase overexpression in the fibrotic lesion...
March 20, 2024: Journal of Inflammation
#35
JOURNAL ARTICLE
Alexander Grath, Guohao Dai
An autologous source of vascular endothelial cells (ECs) is valuable for vascular regeneration and tissue engineering without the concern of immune rejection. The transcription factor ETS variant 2 (ETV2) has been shown to directly convert patient fibroblasts into vascular EC-like cells. However, reprogramming efficiency is low and there are limitations in EC functions, such as eNOS expression. In this study, we directly reprogram adult human dermal fibroblasts into reprogrammed ECs (rECs) by overexpressing SOX17 in conjunction with ETV2...
March 12, 2024: Cell Rep Methods
#36
JOURNAL ARTICLE
Federica M Conedera, Despina Kokona, Martin S Zinkernagel, Jens V Stein, Charles P Lin, Clemens Alt, Volker Enzmann
BACKGROUND: Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of resident microglia and recruited macrophages, critical for tissue remodeling and repair. However, these phagocytes also contribute to chronic inflammation in degenerated retinas, yet the precise coordination of immune response to retinal damage remains elusive. Recent investigations have demonstrated that phagocytic cells can produce extracellular traps (ETs), which are a source of self-antigens that alter the immune response, which can potentially lead to tissue injury...
March 18, 2024: Journal of Neuroinflammation
#37
JOURNAL ARTICLE
Courtney N Johnson, Kandarp A Sojitra, Erich J Sohn, Alma K Moreno-Romero, Antoine Baudin, Xiaoping Xu, Jeetain Mittal, David S Libich
The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyotrophic lateral sclerosis. The fusion protein EWS::FLI1, the causative mutation of Ewing sarcoma, arises from a genomic translocation that fuses a portion of the low-complexity domain (LCD) of EWS (EWSLCD ) with the DNA binding domain of the ETS transcription factor FLI1...
March 16, 2024: Journal of the American Chemical Society
#38
JOURNAL ARTICLE
Marco Antônio Machado Schlindwein, Marcelo Henrique de Moura Campos, Leticia Caroline Breis, Beatriz Sordi Chara, Clara Sasse Scherer, Vitória Augusta Piva Caminski, André Matta, Marcus Vinicius Magno Gonçalves
BACKGROUND: Unlike cigarette smoking, environmental tobacco smoke (ETS) has not been as well described as an environmental risk for Multiple sclerosis (MS) nor as a risk factor for disease progression. OBJECTIVE: We systematically reviewed the association between ETS and the risk of onset and/or progression of MS. METHODS: We systematically screened MedLine/PubMed, Science Direct, LILACs, and SciELO searching for publications between January 1st, 2010, and July 5, 2021, with the following keywords: "multiple sclerosis and smoking"; "multiple sclerosis and passive smoking"; "multiple sclerosis and secondhand smoking"...
March 2024: Arquivos de Neuro-psiquiatria
#39
JOURNAL ARTICLE
Hongyan Liu, Hanyu Pan
This study examines the effects of China's carbon trading policy on firm emissions and explores its impact mechanisms through financial and physical asset investments. The empirical analysis utilizes a fuzzy regression discontinuity design based on a sample of 427 industrial firms in China between 2014 and 2019. The results indicate that China's carbon trading policy incentivized firms to increase their financial investments while simultaneously discouraging physical capital investments. These shifts in investment patterns helped firms achieve their emission reduction targets...
March 13, 2024: Journal of Environmental Management
#40
JOURNAL ARTICLE
Naoki Takeda, Naohiro Makise, Hajime Kageyama, Tsukasa Takahashi, Hiroshi Katoh, Akiko Odaka, Mariko Oikawa, Takahiro Sugiyama, Hidetada Kawana, Akinobu Araki, Hideyuki Kinoshita, Yoko Hagiwara, Hiroto Kamoda, Tsukasa Yonemoto, Makiko Itami
EWSR1::NFATC2 sarcoma, a rare round cell sarcoma constituting the majority of EWSR1::non-ETS sarcomas, has recently been defined in the latest WHO classification. To date, the cytological findings of EWSR1::NFATC2 sarcoma remain undocumented. We present the case of a 25-year-old man with a history of polyostotic fibrous dysplasia in the right leg, referred to our hospital with left thigh pain. Cytological findings included metachromasia, minimally pleomorphic round cells, and eosinophilic infiltration. There was no precursor fibrous dysplasia and the initial diagnosis was undifferentiated pleomorphic sarcoma...
March 14, 2024: Virchows Archiv: An International Journal of Pathology
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