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https://www.readbyqxmd.com/read/27910803/the-prognostic-and-predictive-value-of-tmprss2-erg-gene-fusion-and-erg-protein-expression-in-prostate-cancer-biopsies
#1
Kasper Drimer Berg
BACKGROUND: The clinical course of prostate carcinoma (PCa) is very heterogeneous. Consequently, a personalised approach for risk stratification and treatment planning is important. Recently, it has become evident that PCa, also at the genomic level, is heterogeneous. An early and common alteration is the gene fusion between the transmembrane protease serine 2 (TMPRSS2) gene and the v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene resulting in expression of the oncoprotein ERG...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27907118/end-to-side-neurorrhaphy-as-schwann-cells-provider-to-acellular-nerve-allograft-and-its-suitable-application
#2
Hidekazu Yoshizawa, Daiki Senda, Yuhei Natori, Rica Tanaka, Hiroshi Mizuno, Ayato Hayashi
Axonal regeneration relies on support from proliferating host Schwann cells (SCs), and previous studies on acellular nerve allografts (ANGs) suggest that axons can regenerate into ANGs within a limited distance. Numerous studies have demonstrated that the supplementation of ANGs with exogenous factors, such as cultured SCs, stem cells, and growth factors, promote nerve regeneration in ANGs. However, there are several problems associated with their utilization. In this study, we investigated whether end-to-side (ETS) neurorrhaphy, which is an axonal provider, could be useful as an SC provider to support axonal elongation in ANGs...
2016: PloS One
https://www.readbyqxmd.com/read/27904802/abundance-and-physiology-of-dominant-soft-corals-linked-to-water-quality-in-jakarta-bay-indonesia
#3
Gunilla Baum, Indra Januar, Sebastian C A Ferse, Christian Wild, Andreas Kunzmann
Declining water quality is one of the main reasons of coral reef degradation in the Thousand Islands off the megacity Jakarta, Indonesia. Shifts in benthic community composition to higher soft coral abundances have been reported for many degraded reefs throughout the Indo-Pacific. However, it is not clear to what extent soft coral abundance and physiology are influenced by water quality. In this study, live benthic cover and water quality (i.e. dissolved inorganic nutrients (DIN), turbidity (NTU), and sedimentation) were assessed at three sites (< 20 km north of Jakarta) in Jakarta Bay (JB) and five sites along the outer Thousand Islands (20-60 km north of Jakarta)...
2016: PeerJ
https://www.readbyqxmd.com/read/27898394/mef2-transcription-factors-are-key-regulators-of-sprouting-angiogenesis
#4
Natalia Sacilotto, Kira M Chouliaras, Leonid L Nikitenko, Yao Wei Lu, Martin Fritzsche, Marsha D Wallace, Svanhild Nornes, Fernando García-Moreno, Sophie Payne, Esther Bridges, Ke Liu, Daniel Biggs, Indrika Ratnayaka, Shane P Herbert, Zoltán Molnár, Adrian L Harris, Benjamin Davies, Gareth L Bond, George Bou-Gharios, John J Schwarz, Sarah De Val
Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within specific compartments of the endothelium. However, the molecular links between proangiogenic signals and downstream gene expression remain unclear. During sprouting angiogenesis, the specification of endothelial cells into the tip cells that lead new blood vessel sprouts is coordinated by vascular endothelial growth factor A (VEGFA) and Delta-like ligand 4 (Dll4)/Notch signaling and requires high levels of Notch ligand DLL4...
October 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27893988/endothelin-signaling-in-bone
#5
REVIEW
Jasmin Kristianto, Michael G Johnson, Rafia Afzal, Robert D Blank
The endothelin (ET) system includes 3 small peptide hormones and a pair of G protein-coupled receptors. All 3 ETs are secreted as biologically inert precursors that must be activated by proteolytic cleavage after secretion. This reaction can be catalyzed by a pair of specific, membrane-bound extracellular ET converting enzymes or by nonspecific tissue proteases. The ET1/EDNRA axis is essential in development, with knockout mice for either displaying a similar phenotype featuring multiple defects of the craniofacial skeleton and cardiac outflow tract...
November 11, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27889620/the-fli-1-transcription-factor-is-a-critical-regulator-for-controlling-the-expression-of-chemokine-c-x-c-motif-ligand-2-cxcl2
#6
Ning Lou, Mara L Lennard Richard, Jin Yu, Mark Kindy, Xian K Zhang
Mammalian cells produce inflammatory cytokines and chemokines in response to innate immune signals and their expression is tightly regulated. Chemokine (C-X-C motif) ligand 2 (CXCL2), also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), is an inflammatory chemokine belonging to the CXC chemokine family. CXCL2 is chemotactic for neutrophils and elevated expression of CXCL2 is associated with many inflammatory and autoimmune diseases. The Fli-1 gene belongs to the large Ets transcription factor family, whose members regulate a wide variety of cellular functions including the immune response...
November 24, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27882639/imaging-the-atomic-position-of-light-cations-in-a-porous-network-and-the-europium-iii-ion-exchange-capability-by-aberration-corrected-electron-microscopy
#7
Alvaro Mayoral, Reece M Hall, Roksana Jackowska, Jennifer E Readman
In the present work, ETS-10 microporous titanosilicate has been synthesized and its structure characterized by means of powder XRD and aberration corrected scanning transmission electron microscopy (Cs -corrected STEM). For the first time, sodium ions have been imaged sitting inside the 7-membered rings. The ion-exchange capability has been tested by the inclusion of rare earth metals (Eu, Tb and Gd) to produce a luminescent material which has been studied by atomic-resolution Cs -corrected STEM. The data produced has allowed unambiguous imaging of light atoms in a microporous framework as well as determining the cationic metal positions for the first time, providing evidence of the importance of advanced electron microscopy methods for the study of the local environment of metals within zeolitic supports providing unique information of both systems (guest and support) at the same time...
November 24, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27878357/on-treatment-markers-as-predictors-to-guide-anti-egfr-moab-treatment-in-metastatic-colorectal-cancer-a-systematic-review-with-meta-analysis
#8
REVIEW
Jing Hu, Zhen Zhang, Rui Zheng, Lei Cheng, Mi Yang, Li Li, Baorui Liu, Xiaoping Qian
PURPOSE: Skin toxicity (ST) and early tumor shrinkage (ETS) are early phenomenon during the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) treatment. We conducted a meta-analysis and included relevant studies that reported the impact of ST and ETS on survival- and life quality-based outcome of metastatic colorectal cancer (mCRC) patients treated with anti-EGFR MoAb. METHODS: Relevant studies were identified from PubMed and Embase reporting the correlation of ST and ETS with the clinical outcome of mCRC patients treated with anti-EGFR MoAb...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27878249/ets-1-a-potential-target-of-glycolysis-for-metabolic-therapy-by-regulating-glucose-metabolism-in-pancreatic-cancer
#9
Xiu Zhang, Dan Wu, Mohanad Aldarouish, Xiaodong Yin, Chunyan Li, Cailian Wang
Pancreatic cancer is one of the most lethal malignancies of all types of cancer due to lack of early symptoms and its resistance to conventional therapy. In our previous study, we have shown that v‑ets erythroblastosis virus E26 oncogene homolog‑1 (ETS‑1) promote cell migration and invasion in pancreatic cancer cells. However, the function of ETS‑1 in regulation of glycolysis and autophagy during progression of pancreatic cancer has not been defined yet. In this study, we sought to identify the potential role for silencing ETS‑1 in reducing the expression of glucose transporter‑1 (GLUT‑1) to disturb glycolysis through alteration of 'Warburg effect', by which could result in AMP‑activated protein kinase (AMPK) activation, autophagy induction and reduction of cell viability...
November 16, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27878126/validity-of-the-electronic-triage-system-in-predicting-patient-outcomes-in-tabriz-iran-a-cross-sectional-study
#10
Faramarz Pourasghar, Jafar Sadegh Tabrizi, Alireza Ala, Amin Daemi
OBJECTIVE: To validate the triage ratings performed by the Electronic Triage System (ETS) using hospitalization, length of stay, resource use, in-hospital mortality and patient bills as outcome measures. METHODS: In this retrospective cross-sectional study the medical records of 387 patients were reviewed in a one-week period. The data included triage category and the outcome measures were hospitalization, length of stay, in-hospital mortality, patient bill, and used resources...
October 2016: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/27875302/proteasomal-degradation-of-the-ews-fli1-fusion-protein-is-regulated-by-a-single-lysine-residue
#11
Maria E Gierisch, Franziska Pfistner, Laura A Lopez-Garcia, Lena Harder, Beat W Schäfer, Felix K Niggli
E-26 transformation specific (ETS) proteins are transcription factors directing gene expression through their conserved DNA-binding domain. They are implicated as truncated forms or interchromosomal rearrangements in a variety of tumors including Ewing sarcoma, a pediatric tumor of the bone. Tumor cells express the chimeric oncoprotein EWS-FLI1 from a specific t(22;11)(q24;12) translocation. EWS-FLI1 harbors a strong transactivation domain from EWSR1 and the DNA-binding ETS domain of FLI1 in the C-terminal part of the protein...
November 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27870587/17%C3%AE-estradiol-enhances-vascular-endothelial-ets-1-mir-126-3p-expression-the-possible-mechanism-for-attenuation-of-atherosclerosis
#12
Ping Li, Jinzhi Wei, Xiaosa Li, Yang Cheng, Weiyu Chen, Yuhong Cui, Tommaso Simoncini, Zhengtian Gu, Jun Yang, Xiaodong Fu
CONTEXT: Endothelial microRNA 126 (miR-126) attenuates the development of atherosclerosis (AS). However, there is no evidence showing the role of miR-126 in estrogen's anti-atherogenic effects. OBJECTIVE: We hypothesized that 17β-estradiol (E2) modulates miR-126 expression, thus may improve endothelial function and retard AS development. DESIGN/SETTING/PARTICIPANTS: This was a prospective cohort study of 12 healthy regularly menstruating female volunteers aged 23-26 yr conducted at Guangzhou Medical University...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27866749/inter-population-and-inter-organ-distribution-of-the-main-polyphenolic-compounds-of-epilobium-angustifolium
#13
Nicolas Baert, Jorma Kim, Maarit Karonen, Juha-Pekka Salminen
Rosebay willowherb (Epilobium angustifolium) contains large amounts of polyphenolic compounds, including tellimagrandin I-based oligomeric ellagitannins (ETs). The aim of this study was to assess the interpopulational and inter-organ variability of the polyphenol fingerprint of E. angustifolium. Seven ETs, 11 flavonol glycosides and neochlorogenic acid were quantified by UHPLC-DAD-ESI-QqQ-MS in the leaves, flowers and stem parts of plants from 10 populations. Total polyphenol content of leaves and flowers ranged from 150 to 200 mg/g dry wt, of which 90% was constituted by dimeric to heptameric ETs...
November 17, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27853318/the-androgen-induced-protein-aibzip-facilitates-proliferation-of-prostate-cancer-cells-through-downregulation-of-p21-expression
#14
Xiang Cui, Min Cui, Rie Asada, Soshi Kanemoto, Atsushi Saito, Koji Matsuhisa, Masayuki Kaneko, Kazunori Imaizumi
Androgen-Induced bZIP (AIbZIP) is structurally a bZIP transmembrane transcription factor belonging to the CREB/ATF family. This molecule is highly expressed in androgen-sensitive prostate cancer cells and is transcriptionally upregulated by androgen treatment. Here, we investigated molecular mechanism of androgen-dependent expression of AIbZIP and its physiological function in prostate cancer cells. Our data showed that SAM pointed domain-containing ETS transcription factor (SPDEF), which is upregulated by androgen treatment, directly activates transcription of AIbZIP...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853040/an-epidemiological-profile-of-chronic-obstructive-pulmonary-disease-a-community-based-study-in-delhi
#15
B Sinha, R Singla, R Chowdhury
BACKGROUND: Different definitions used for chronic obstructive pulmonary disease (COPD) preclude getting reliable prevalence estimates. Study objective was to find the prevalence of COPD as per standard Global Initiative for Chronic Obstructive Lung Disease definition, risk factors associated, and treatment seeking in adults >30 years. METHODOLOGY: Community-based cross-sectional study was conducted in Delhi, among 1200 adults, selected by systematic random sampling...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27852061/thyroid-transcription-factor-foxe1-interacts-with-ets-factor-elk1-to-co-regulate-tert
#16
Martyn Bullock, Grace Lim, Cheng Li, In Ho Choi, Shivansh Kochhar, Chris Liddle, Lei Zhang, Roderick J Clifton-Bligh
BACKGROUND: Although FOXE1 was initially recognized for its role in thyroid organogenesis, more recently a strong association has been identified between the FOXE1 locus and thyroid cancer. The role of FOXE1 in adult thyroid, and in particular regarding cancer risk, has not been well established. We hypothesised that discovering key FOXE1 transcriptional partners would in turn identify regulatory pathways relevant to its role in oncogenesis. RESULTS: In a transcription factor-binding array, ELK1 was identified to bind FOXE1...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27825108/runx2-a-novel-regulator-for-goblet-cell-differentiation-and-asthma-development
#17
Ning Shi, Jing Zhang, Shi-You Chen
Airway goblet-cell differentiation and related mucus overproduction are critical processes in the development of respiratory diseases, including asthma. The underlying mechanisms, however, are not fully understood. We identified Runt-related transcription factor 2 (Runx2) as a novel regulator for goblet-cell differentiation. Runx2 was up-regulated by 6.4-fold during IL-13-induced goblet-cell differentiation of human bronchial epithelial cells. Knockdown of Runx2 attenuated the IL-13-induced differentiation/mucus production by 67%...
October 17, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27822884/lncrna-ak015322-promotes-proliferation-of-spermatogonial-stem-cell-c18-4-by-acting-as-a-decoy-for-microrna-19b-3p
#18
Ke Hu, Jing Zhang, Meng Liang
Long noncoding RNAs (lncRNAs) have been reported to play important roles in male reproduction. In our previous research, we studied the expression profile of lncRNAs in mouse male germ cells including spermatogonial stem cell, type A spermatogonia, pachytene spermatocyte, and round spermatid by microarray method, which showed that testis-enriched lncRNA AK015322 is highly expressed in spermatogonial stem cell. In this study, we found that AK015322 promotes proliferation of mouse spermatogonial stem cell line C18-4 in vitro...
November 7, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27820701/microrna-424-impairs-ubiquitination-to-activate-stat3-and-promote-prostate-tumor-progression
#19
Cecilia Dallavalle, Domenico Albino, Gianluca Civenni, Jessica Merulla, Paola Ostano, Maurizia Mello-Grand, Simona Rossi, Marco Losa, Gioacchino D'Ambrosio, Fausto Sessa, George N Thalmann, Ramon Garcia-Escudero, Andrea Zitella, Giovanna Chiorino, Carlo V Catapano, Giuseppina M Carbone
Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations in protein turnover are important mechanisms in driving tumorigenesis. Here we describe an alternative mechanism involving upregulation of the microRNA miR-424 that leads to impaired ubiquitination and degradation of oncogenic transcription factors in prostate cancers. We found that miR-424 targets the E3 ubiquitin ligase COP1 and identified STAT3 as a key substrate of COP1 in promoting tumorigenic and cancer stem-like properties in prostate epithelial cells...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27818821/disseminated-cerebrospinal-embryonal-tumor-in-the-adult
#20
Alessandro Caporlingua, Daniele Armocida, Federico Caporlingua, Gennaro Lapadula, Grazia Maria Elefante, Manila Antonelli, Maurizio Salvati
Introduction. According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). We present a case of disseminated cerebrospinal ET presenting in an adult patient. Illustrative Case. A 49-year-old male presenting with low back pain, dysuria, and hypoesthesia of the lower extremities referred to our emergency department. Brain and whole spine contrast-enhanced MRI documented a diffusively disseminated heterogeneous neoplasm with intradural extra- and intramedullary involvement of the cervicothoracic tract and cauda equina...
2016: Case Reports in Pathology
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