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https://www.readbyqxmd.com/read/29458112/compatible-osmolytes-modulate-mitochondrial-function-in-a-marine-osmoconformer-crassostrea-gigas-thunberg-1793
#1
Eugene P Sokolov, Inna M Sokolova
Salinity is an important environmental factor affecting physiology of marine organisms. Osmoconformers such as marine mollusks maintain metabolic function despite changes of the osmolarity and composition of the cytosol during salinity shifts. Currently, metabolic responses to the salinity-induced changes of the intracellular milieu are not well understood. We studied the effects of osmolarity (450 vs. 900 mOsm) and compatible osmolytes (70-590 mM of taurine or betaine) on isolated gill mitochondria of a marine osmoconformer, the Pacific oyster Crassostrea gigas...
February 16, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29457513/qualifying-the-difficulty-of-embryo-transfer-with-a-visual-analogue-scale-and-assessing-its-impact-on-ivf-outcomes
#2
Edward Coats, Hannah Carden, Lyndsey Zujovic, Walid Maalouf, James Hopkisson, Nicholas Raine-Fenning
The aim of this study was to determine whether a continuous visual analogue scale (VAS) is a reliable tool to grade embryo transfer (ET) difficulty when assessing IVF outcomes. No standardized grading system exists for reporting ET 'difficulty' which is typically recorded in descriptive terms. Clinicians performing 188 fresh single ETs between November 2014 and May 2016 also recorded a VAS score (0-100). Embryo transfers were stratified into three levels of ET 'difficulty': (A) 'easy' - no resistance; (B) 'medium' - resistance overcome by advancing the catheter's outer sheath; and (C) 'difficult' - a malleable stylet was required to overcome resistance; and these compared to the VAS scores...
February 19, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29456897/detection-of-essential-tremor-at-the-formula-see-text-band
#3
Xiaodong Yang, Syed Aziz Shah, Aifeng Ren, Dou Fan, Nan Zhao, Dongjian Cao, Fangming Hu, Masood Ur Rehman, Weigang Wang, Karen M Von Deneen, Jie Tian
Essential tremor (ET) is a neurological disorder characterized by rhythmic, involuntary shaking of a part or parts of the body. The most common tremor is seen in the hands/arms and fingers. This paper presents an evaluation of ETs monitoring based on finger-to-nose test measurement as captured by small wireless devices working in shortwave or [Formula: see text]-band frequency range. The acquired signals in terms of amplitude and phase information are used to detect a tremor in the hands. Linearly transforming raw phase data acquired in the [Formula: see text]-band were carried out for calibrating the phase information and to improve accuracy...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29455655/disruption-of-etv6-leads-to-twist1-dependent-progression-and-resistance-to-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-prostate-cancer
#4
Yuan-Chin Tsai, Tao Zeng, Wassim Abou-Kheir, Hsiu-Lien Yeh, Juan Juan Yin, Yi-Chao Lee, Wei-Yu Chen, Yen-Nien Liu
BACKGROUND: ETS variant gene 6 (ETV6) is a putative tumor suppressor and repressed by epidermal growth factor receptor (EGFR) signaling in prostate cancer. Since EGFR antagonists seem ineffective in castration-resistant prostate cancer (CRPC), we aim to study the role of ETV6 in the development of drug resistance. METHODS: Etv6 target gene was validated by ChIP and promoter reporter assays. Correlation of ETV6 and TWIST1 was analyzed in human clinical datasets and tissue samples...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29442875/adsorption-of-cu-2-ions-from-aqueous-solutions-on-nano-titanate-engelhard-titanosilicate-2-ets-2
#5
Sabereh Rezaei, Steven M Kuznicki
Adsorption of Cu2+ ions from aqueous solutions is an increasingly important problem. Nano-titanate ETS-2 (Engelhard Titanosilicate-2) was studied for Cu2+ removal from aqueous solutions through the batch technique at room temperature. Structural and chemical properties of both ETS-2 sorbent and aqueous solution were studied by different characterization tests such as Thermogravimetric Analysis, Energy Dispersive X-ray spectroscopy, X-ray Photoelectron Spectroscopy and Inductively Coupled Plasma measuremen. Copper adsorption capacity was found to increase upon raising the contact time or the pH of the solution...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442044/microrna-3188-targets-ets-domain-protein-4-and-participates-in-rhoa-rock-pathway-to-regulate-the-development-of-atherosclerosis
#6
Na Li, Jinghong Chen, Jingru Zhao, Tianjun Wang
We aimed to elucidate the roles and regulatory mechanism of miR-3188 in oxidized low-density lipoprotein (ox-LDL)-induced cell injury in THP-1 derived macrophages, thus providing a new insight for the treatment of atherosclerosis (AS). A total of 85 AS patients and 45 healthy controls were enrolled. The levels of miR-3188 and lipoprotein-associated phospholipase A2 (Lp-PLA2) in AS patients and healthy controls were detected. Then ox-LDL was used to treat human THP-1 derived macrophages. The effects of overexpression and suppression of miR-3188 on regulating ox-LDL-induced cell injury in THP-1 derived macrophages were investigated...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29430111/scintigraphic-evaluation-of-esophageal-motility-and-gastroesophageal-reflux-in-patients-presenting-with-upper-respiratory-tract-symptoms
#7
Jaykanth Amalachandran, Shelley Simon, Indirani Elangoven, Avani Jain, Thangalakshmi Sivathapandi
Purpose of Study: The purpose is to evaluate the findings and utility of esophageal transit scintigraphy (ETS) and gastroesophageal reflux scintigraphy (GES) in patients presenting with upper respiratory tract (URT) symptoms suspected to be due to gastroesophageal reflux (GER) disease. Materials and Methods: Thirty patients aged between 19 and 60 years underwent nasopharyngolaryngoscopy (NPL), ETS, and GES. Correlation between GER, esophageal motility, and NPL was evaluated...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29425299/stability-of-ethyl-glucuronide-ethyl-sulfate-phosphatidylethanols-and-fatty-acid-ethyl-esters-in-postmortem-human-blood
#8
Yuming Liu, Xinyu Zhang, Jiaolun Li, Zhibin Huang, Zebin Lin, Jingru Wang, Chengqiang Zhang, Yulan Rao
Background: The lack of systematic studies on the stability of ethanol's non-oxidative metabolites in postmortem specimens restricts their use in forensic cases. This study aimed to compare the stability of ethyl glucuronide (EtG), ethyl sulfate (EtS), phosphatidylethanols (PEths) and fatty acid ethyl esters (FAEEs) in postmortem human blood. Method: Three groups were established based on the level and source of ethanol: the blank group, the ethanol-spiked group and the ethanol-positive group...
February 7, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29417847/clinical-outcomes-of-endoscopic-versus-microscopic-trans-sphenoidal-surgery-for-large-pituitary-adenoma
#9
Hamideh Akbari, Mojtaba Malek, Mohammad Ghorbani, Seyed Mahmoud Ramak Hashemi, Mohammad Ebrahim Khamseh, Ali Zare Mehrjardi, Zahra Emami, Ameneh Ebrahim Valojerdi
OBJECTIVE: To compare clinical outcomes of large pituitary adenomas (≥3 cm in maximum diameter), operated on by Endoscopic Transsphenoidal Surgery (ETS), versus Microscopic Transsphenoidal Surgery (MTS). METHODS: Medical records and MRI Scans of patients with a diagnosis of pituitary adenoma for whom transphenoidal surgery was done were reviewed. Complete pre and post-operative data were available for 121 patients. Thirty five patients had large pituitary adenoma and were enrolled in this study...
February 8, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29416716/robust-diagnosis-of-ewing-sarcoma-by-immunohistochemical-detection-of-super-enhancer-driven-ewsr1-ets-targets
#10
Michaela C Baldauf, Martin F Orth, Marlene Dallmayer, Aruna Marchetto, Julia S Gerke, Rebeca Alba Rubio, Merve M Kiran, Julian Musa, Maximilian M L Knott, Shunya Ohmura, Jing Li, Nusret Akpolat, Ayse N Akatli, Özlem Özen, Uta Dirksen, Wolfgang Hartmann, Enrique de Alava, Daniel Baumhoer, Giuseppina Sannino, Thomas Kirchner, Thomas G P Grünewald
Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive diagnosis, substantial confusion can arise if molecular diagnostics are unavailable. Diagnosis based on the conventional immunohistochemical marker CD99 is unreliable due to its abundant expression in morphological mimics. To identify novel diagnostic immunohistochemical markers for Ewing sarcoma, we performed comparative expression analyses in 768 tumors representing 21 entities including Ewing-like sarcomas, which confirmed that CIC-DUX4-, BCOR-CCNB3-, EWSR1-NFATc2-, and EWSR1-ETS-translocated sarcomas are distinct entities, and revealed that ATP1A1, BCL11B, and GLG1 constitute specific markers for Ewing sarcoma...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416688/kshv-lana-upregulates-the-expression-of-epidermal-growth-factor-like-domain-7-to-promote-angiogenesis
#11
Suhani Thakker, Roxanne C Strahan, Alexandra N Scurry, Timsy Uppal, Subhash C Verma
Kaposi's sarcoma (KS) is a highly-vascularized tumor characterized by inflammation and extensive neo-angiogenesis. The KS tumor microenvironment is rich in inflammatory and pro-angiogenic cytokines. Here, we report that the expression of Epidermal growth factor-like domain 7 (EGFL7) is upregulated in Kaposi's sarcoma-associated herpes virus (KSHV) infected cells. EGFL7 is a secreted pro-angiogenic cytokine that has been implicated in angiogenesis and the proliferation of endothelial cells during many pathological conditions...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415888/goblet-cell-loss-abrogates-ocular-surface-immune-tolerance
#12
Byung Yi Ko, Yangyan Xiao, Flavia L Barbosa, Cintia S de Paiva, Stephen C Pflugfelder
Intestinal epithelial cells condition tolerogenic properties in DCs. Aqueous-deficient dry eye is associated with goblet cell (GC) loss and increased IFN-γ expression in the conjunctiva. We hypothesized that loss of GCs reduces tolerance-inducing properties of antigen presenting cells (APCs) in the conjunctiva and draining nodes. Mice lacking the SAM pointed domain containing ETS transcription factor (Spdef) that is required for GC differentiation had an increased frequency of macrophages in the conjunctiva and CD11b+CD11c+ DCs in the conjunctiva and draining nodes, and these cells had greater IL-12 expression than WT mice...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29412022/tailor-made-ph-sensitive-poly-acrylic-acid-functionalized-mesoporous-silica-nanoparticles-for-efficient-and-controlled-delivery-of-anti-cancer-drug-etoposide
#13
Seema Saroj, Sadhana J Rajput
A multifaceted therapeutic platform has been proposed for controlled delivery of Etoposide (ETS) leading to a synergistic advantage of maximum therapeutic efficacy and diminished toxicity. A state of the art pH responsive nanoparticles (NPs) MSNs-PAA consisting of mesoporous silica nanoparticles core and polymeric shell layers, were developed for controlled release of model anti-cancer drug ETS. Graft onto strategy was employed and amination served as an interim step, laying a vital foundation for functionalization of the MSN core with hydrophilic and pH responsive polyacrylic acid (PAA)...
February 7, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29410543/efficacy-of-modified-tochen-s-formula-for-optimum-endotracheal-tube-placement-in-low-birth-weight-neonates-an-rct
#14
Dharamveer Tatwavedi, Saudamini V Nesargi, Nachiket Shankar, Priyanka Mathias, Suman Rao Pn
OBJECTIVE: To assess the efficacy of modified Tochen's formula (birth weight + 5 cm) when compared to Tochen's formula for optimum placement of endotracheal tubes (ET) in low birth weight (LBW) neonates. STUDY DESIGN: In the NICU of a tertiary care hospital, LBW babies requiring intubation were randomized to Tochen's formula or modified Tochen's formula. The incidence of inadequate placement and optimum length of ET insertion were estimated. Analysis was done by the Chi square and 't'-tests...
February 6, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29409947/de-escalating-systemic-therapy-in-triple-negative-breast-cancer-the-example-of-secretory-carcinoma
#15
Julie-Charlotte Benabu, François Stoll, Antoine Koch, Sébastien Molière, Jean-Pierre Bellocq, Carole Mathelin
Triple negative breast cancers have the highest relapse risk and the least favourable prognosis of all breast cancer subtypes, leading to an escalation of chemotherapy, substantially during recent years. Secretory carcinoma of the breast is a rare triple negative neoplasm, first described in children but more often presenting in adults. We report a case of a 70-years-old woman, initially diagnosed on the biopsy with a triple negative infiltrating NOS (Not Otherwise Specified) carcinoma of the breast, before it was later correctly identified as a secretory carcinoma, notably because of an abundant intra and extracellular secretory material...
January 30, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29404728/earthworm-coelomocyte-extracellular-traps-structural-and-functional-similarities-with-neutrophil-nets
#16
REVIEW
Joanna Homa
Invertebrate immunity is associated with natural mechanisms that include cellular and humoral elements, similar to those that play a role in vertebrate innate immune responses. Formation of extracellular traps (ETs) is a newly discovered mechanism to combat pathogens, operating not only in vertebrate leucocytes but also in invertebrate immune cells. The ET components include extracellular DNA (exDNA), antimicrobial proteins and histones. Formation of mammalian ETs depends on enzymes such as neutrophil elastase, myeloperoxidase, the citrullination of histones and protease activity...
February 5, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29396776/dft-studies-of-hydrocarbon-combustion-on-metal-surfaces
#17
Mina Arya, Ali Akbar Mirzaei, Abdol Mahmood Davarpanah, Seyed Masoud Barakati, Hossein Atashi, Abas Mohsenzadeh, Kim Bolton
Catalytic combustion of hydrocarbons is an important technology to produce energy. Compared to conventional flame combustion, the catalyst enables this process to operate at lower temperatures; hence, reducing the energy required for efficient combustion. The reaction and activation energies of direct combustion of hydrocarbons (CH → C + H) on a series of metal surfaces were investigated using density functional theory (DFT). The data obtained for the Ag, Au, Al, Cu, Rh, Pt, and Pd surfaces were used to investigate the validity of the Brønsted-Evans-Polanyi (BEP) and transition state scaling (TSS) relations for this reaction on these surfaces...
February 2, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29393482/cooperation-between-ets-variant-2-and-jumonji-domain%C3%A2-containing-2-histone-demethylases
#18
Xiaomeng Li, Gene Moon, Sook Shin, Bin Zhang, Ralf Janknecht
The E26 transformation-specific (ETS) variant 2 (ETV2) protein, also designated as ETS-related 71, is a member of the ETS transcription factor family and is essential for blood and vascular development in the embryo. The role of ETV2 in cancer has not yet been investigated. In the present study, the expression of ETV2 mRNA was identified in a variety of tumor types, including prostate carcinoma. In addition, ETV2 gene amplification was identified in several types of cancer, suggesting that ETV2 plays an oncogenic role in tumorigenesis...
January 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29391372/normal-saline-instillation-versus-no-normal-saline-instillation-and-lung-recruitment-versus-no-lung-recruitment-with-paediatric-endotracheal-suction-the-nares-trial-a-study-protocol-for-a-pilot-factorial-randomised-controlled-trial
#19
Jessica A Schults, Marie Cooke, Debbie A Long, Andreas Schibler, Robert S Ware, Marion L Mitchell
INTRODUCTION: Endotracheal suction (ETS) is a frequent and necessary airway intervention for the intubated child. The aim of ETS is to clear the endotracheal tube and airways of respiratory secretions; however, the methods of performing ETS are varied. Internationally a number of ETS treatments are in use. Many have not been rigorously evaluated in a randomised controlled trial setting, and it is uncertain whether any are associated with better outcomes for the critically ill child. With approximately 50% of paediatric intensive care admissions requiring intubation, ETS interventions that maximise the efficacy and minimise the complications of ETS could translate to improved health for substantial numbers of critically ill children, and significant cost savings...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29391174/dna-extracellular-traps-are-part-of-the-immune-repertoire-of-periplaneta-americana
#20
M T C Nascimento, K P Silva, M C F Garcia, M N Medeiros, E A Machado, S B Nascimento, E M Saraiva
Extracellular traps (ETs), web-like structures composed of DNA and histones, are released by innate immune cells in a wide range of organisms. ETs capture microorganisms, thereby avoiding their spread, and also concentrate antimicrobial molecules, which helps to kill microbes. Although vertebrate innate immune systems share homology with the insect immune system, ETosis have yet to be characterized in insects. Here, we report that the hemocytes of the hemimetabolous insect Periplaneta americana release ETs upon in vitro stimulation...
January 29, 2018: Developmental and Comparative Immunology
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