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https://www.readbyqxmd.com/read/28077390/reversible-temperature-dependent-differences-in-brown-adipose-tissue-respiration-during-torpor-in-a-mammalian-hibernator
#1
Sarah Victoria McFarlane, Katherine E Mathers, James F Staples
While seasonal modifications of brown adipose tissue (BAT) in hibernators are well documented, we know little about functional regulation of BAT in different phases of hibernation. In the 13-lined ground squirrel, liver mitochondrial respiration is suppressed by up to 70% during torpor. This suppression is reversed during arousal an°°d interbout euthermia (IBE), and corresponds with patterns of maximal activities of electron transport system (ETS) enzymes. Uncoupling of BAT mitochondria is controlled by free-fatty acid release stimulated by sympathetic activation of adipocytes, so we hypothesized that further regulation at the level of the ETS would be of little advantage...
January 11, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28076810/dna-occupancy-of-polymerizing-transcription-factors-a-chemical-model-of-the-ets-family-factor-yan
#2
C Matthew Hope, Ilaria Rebay, John Reinitz
Transcription factors use both protein-DNA and protein-protein interactions to assemble appropriate complexes to regulate gene expression. Although most transcription factors operate as monomers or dimers, a few, including the E26 transformation-specific family repressors Drosophila melanogaster Yan and its human homolog TEL/ETV6, can polymerize. Although polymerization is required for both the normal and oncogenic function of Yan and TEL/ETV6, the mechanisms by which it influences the recruitment, organization, and stability of transcriptional complexes remain poorly understood...
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28065200/testing-the-start-triage-protocol-can-it-improve-the-ability-of-nonmedical-personnel-to-better-triage-patients-during-disasters-and-mass-casualties-incidents
#3
Stefano Badiali, Aimone Giugni, Lucia Marcis
OBJECTIVE: START (Simple Triage and Rapid Treatment) triage is a tool that is available even to nonmedical rescue personnel in case of a disaster or mass casualty incident (MCI). In Italy, no data are available on whether application of the START protocol could improve patient outcomes during a disaster or MCI. We aimed to address whether "last-minute" START training of nonmedical personnel during a disaster or MCI would result in more effective triage of patients. METHODS: In this case-control study, 400 nonmedical ambulance crew members were randomly assigned to a non-START or a START group (200 per group)...
January 9, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28055206/exploring-ultrashort-hydrogen-hydrogen-non-bonded-contacts-in-constrained-molecular-cavities
#4
Nilangshu Mandal, Saied Md Pratik, Ayan Datta
Confined molecular chambers like macrocycle bridged E1-H…H-E2 (E1(E2)=Si(Si), 1) exhibit rare ultrashort H…H non-bonded contacts (d(H…H)=1.56 Å). In this article, based on density functional theory (DFT) and Ab-Initio Molecular Dynamics (AIMD) simulations, we propose new molecular motifs where d(H…H) can be reduced to 1.44 Å (E1(E2)=Si (Ge), 3). Further tuning the structure of the macrocycle by replacing the bulky phenyl groups by ethylenic spacers and substitution the H-atoms by -CN groups makes the cavity more compact and furnishes even shorter d(H…H)=1...
January 5, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28052010/a-screen-for-fli-1-transcriptional-modulators-identifies-pkc-agonists-that-induce-erythroid-to-megakaryocytic-differentiation-and-suppress-leukemogenesis
#5
Tangjingjun Liu, Yao Yao, Gang Zhang, Ye Wang, Bin Deng, Jialei Song, Xiaogang Li, Fei Han, Xiao Xiao, Jue Yang, Lei Xia, You-Jun Li, Maksym Plachynta, Mu Zhang, Chen Yan, Shuzhen Mu, Heng Luo, Eldad Zacksenhaus, Xiaojiang Hao, Yaacov Ben-David
The ETS-related transcription factor Fli-1 affects many developmental programs including erythroid and megakaryocytic differentiation, and is frequently de-regulated in cancer. Fli-1 was initially isolated following retrovirus insertional mutagenesis screens for leukemic initiator genes, and accordingly, inhibition of this transcription factor can suppress leukemia through induction of erythroid differentiation. To search for modulators of Fli-1, we hereby performed repurposing drug screens with compounds isolated from Chinese medicinal plants...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28050800/micro-rna-204-participates-in-tmprss2-erg-regulation-and-androgen-receptor-reprogramming-in-prostate-cancer
#6
Krassimira Todorova, Metodi V Metodiev, Gergana Metodieva, Milcho Mincheff, Nelson Fernández, Soren Hayrabedyan
Cancer progression is driven by genome instability incurred rearrangements such as transmembrane protease, serine 2 (TMPRSS2)/v-ets erythroblastosis virus E26 oncogene (ERG) that could possibly turn some of the tumor suppressor micro-RNAs into pro-oncogenic ones. Previously, we found dualistic miR-204 effects, acting either as a tumor suppressor or as an oncomiR in ERG fusion-dependent manner. Here, we provided further evidence for an important role of miR-204 for TMPRSS2/ERG and androgen receptor (AR) signaling modulation and fine tuning that prevents TMPRSS2/ERG overexpression in prostate cancer...
January 3, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28041791/activity-of-etv5a-and-etv5b-genes-in-the-hypothalamus-of-fasted-zebrafish-is-influenced-by-serotonin
#7
Alejandro S Mechaly, Ebony Richardson, Silke Rinkwitz
Serotonin has been implicated in the inhibition of food intake in vertebrates. However, the mechanisms through which serotonin acts has yet to be elucidated. Recently, ETV5 (ets variant gene 5) has been associated with obesity and food intake control mechanisms in mammals. We have analyzed a putative physiological function of the two etv5 paralogous genes (etv5a and etv5b) in neuronal food intake control in adult zebrafish that have been exposed to different nutritional conditions. A feeding assay was established and fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), was applied...
December 29, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28039826/indoor-airborne-particle-sources-and-outdoor-haze-days-effect-in-urban-office-areas-in-guangzhou
#8
Manwen Zhang, Sukun Zhang, Guixian Feng, Hui Su, Fengzhi Zhu, Mingzhong Ren, Zongwei Cai
To identify the sources of PM2.5 pollutants in work environments and determine whether the air quality inside an office was affected by a change in outdoor pollution status, concurrent indoor and outdoor measurements of PM2.5 were conducted at five different office spaces in the urban center of Guangzhou on low pollution days (non-episode days, NEDs), and high pollution days (haze episode days, EDs). Indoor-outdoor relationships between the PM2.5 mass and its chemical constituents, which included water-soluble ions, carbonaceous species, and metal elements, were investigated...
December 28, 2016: Environmental Research
https://www.readbyqxmd.com/read/28032641/relation-of-early-tumor-shrinkage-ets-observed-in-first-line-treatment-to-efficacy-parameters-of-subsequent-treatment-in-fire-3-aiokrk0306
#9
D P Modest, S Stintzing, L Fischer von Weikersthal, T Decker, A Kiani, U Vehling-Kaiser, S-E Al-Batran, T Heintges, C Lerchenmüller, C Kahl, G Seipelt, F Kullmann, W Scheithauer, T Kirchner, A Jung, M Stauch, J C von Einem, M Moehler, S Held, V Heinemann
We explored the association of early tumor shrinkage (ETS) and non-ETS with efficacy of first-line and consecutive second-line treatment in patients with KRAS wild-type metastatic colorectal cancer treated in FIRE-3. Assessment of tumor shrinkage was based on the sum of longest diameters of target lesions, evaluated after six weeks of treatment. Shrinkage was classified as ETS (shrinkage by ≥ 20%), mETS (shrinkage by 0% - <20%), mPD (minor progression >0% - <20%) and PD (progression ≥20%). Overall survival (OS) was 33...
December 29, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28032061/indoor-environmental-factors-and-occurrence-of-lung-function-decline-in-adult-residents-in-summer-in-southwest-china
#10
Yu Jie, Li Kebin, Tang Yin, Xu Jie
BACKGROUND: There is conflicting reports on the respiratory health effects of indoor risk factor exposure. The aim of this study was to assess the association of indoor environmental factors to pulmonary function in an adult population in Zunyi City of Southwest China. METHODS: Between July and Sep 2012, we conducted a cross-sectional survey of people aged ≥18 yr in 11 inner-city areas of Zunyi. Data on asthma and asthma-related symptoms and selected home environmental factors were assessed by questionnaire...
November 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28030795/aml-associated-oncofusion-proteins-pml-rara-aml1-eto-and-cbfb-myh11-target-runx-ets-factor-binding-sites-to-modulate-h3ac-levels-and-drive-leukemogenesis
#11
Abhishek A Singh, Amit Mandoli, Koen H M Prange, Marko Laakso, Joost H A Martens
Chromosomal translocations are one of the hallmarks of acute myeloid leukemia (AML), often leading to gene fusions and expression of an oncofusion protein. Over recent years it has become clear that most of the AML associated oncofusion proteins molecularly adopt distinct mechanisms for inducing leukemogenesis. Still these unique molecular properties of the chimeric proteins converge and give rise to a common pathogenic molecular mechanism. In the present study we compared genome-wide DNA binding and transcriptome data associated with AML1-ETO, CBFB-MYH11 and PML-RARA oncofusion protein expression to identify unique and common features...
December 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/28026128/ets-transcription-factor-etv2-er71-etsrp-in-hematopoietic-and-vascular-development-injury-and-regeneration
#12
REVIEW
Haiyong Zhao, Canxin Xu, Taejin Lee, Fang Liu, Kyunghee Choi
The major goal in regenerative medicine is to repair and restore injured, diseased or aged tissue function, thereby promoting general health. As such, the field of regenerative medicine has great translational potential in undertaking many of the health concerns and needs that we currently face. In particular, hematopoietic and vascular systems supply oxygen and nutrients and thus play critical roles in tissue development and tissue regeneration. Additionally, tissue vasculature serves as a tissue stem cell niche and thus contributes to tissue homeostasis...
December 27, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28011616/targeted-epigenetic-editing-of-spdef-reduces-mucus-production-in-lung-epithelial-cells
#13
Juan Song, David Cano Rodriguez, Melanie Winkle, Rutger A F Gjaltema, Désirée Goubert, Tomasz P Jurkowski, Irene H Heijink, Marianne G Rots, Machteld N Hylkema
Airway mucus hypersecretion contributes to the morbidity and mortality in patients with chronic inflammatory lung diseases. Reducing mucus production is crucial for improving patients' quality of life. The transcription factor SAM-pointed domain-containing Ets-like factor (SPDEF) plays a critical role in the regulation of mucus production, and therefore represents a potential therapeutic target. This study aims to reduce lung epithelial mucus production by targeted silencing SPDEF using the novel strategy epigenetic editing...
December 23, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28009307/ets-factors-regulate-neural-stem-cell-depletion-and-gliogenesis-in-ras-pathway-glioma
#14
Joshua J Breunig, Rachelle Levy, C Danielle Antonuk, Jessica Molina, Marina Dutra-Clarke, Hannah Park, Aslam Abbasi Akhtar, Gi Bum Kim, Terrance Town, Xin Hu, Serguei I Bannykh, Roel G W Verhaak, Moise Danielpour
No abstract text is available yet for this article.
December 20, 2016: Cell Reports
https://www.readbyqxmd.com/read/28008100/melatonin-protects-against-uric-acid-induced-mitochondrial-dysfunction-oxidative-stress-and-triglyceride-accumulation-in-c2c12-myotubes
#15
Gerald J Maarman, Brittany M Andrew, Dee M Blackhurst, Edward O Ojuka
Excess uric acid has been shown to induce oxidative stress, triglyceride accumulation and mitochondrial dysfunction in the liver and is an independent predictor of type-2 diabetes. Skeletal muscle plays a dominant role in type 2 diabetes and presents a large surface area to plasma uric acid. However, the effects of uric acid on skeletal muscle is underinvestigated. Our aim was therefore to characterize the effects of excessive uric acid on oxidative stress, triglyceride content and mitochondrial function in skeletal muscle C2C12 tubes and assess how these are modulated by the antioxidant molecule, melatonin...
December 22, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27998921/the-performance-of-alcohol-markers-including-ethyl-glucuronide-and-ethyl-sulphate-to-detect-alcohol-use-in-clients-in-a-community-alcohol-treatment-programme
#16
Jane M Armer, Lihini Gunawardana, Rebecca L Allcock
AIMS: The ethanol metabolites ethyl glucuronide (EtG) and ethyl sulphate (EtS) are detectable for longer in urine than breath ethanol or urine ethanol after alcohol intake. This study compared the performance of breath ethanol, urine ethanol, urine EtG and EtS to detect alcohol consumption in clients in community alcohol treatment. METHODS: Clients attending the community alcohol treatment programme were asked to provide an alcohol diary, breathalyser test and urine for ethanol, EtG and EtS measurement (n = 42)...
January 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27998006/pravastatin-attenuates-the-action-of-the-ets-domain-containing-protein-elk1-to-prevent-atherosclerosis-in-apolipoprotein-e-knockout-mice-via-modulation-of-extracellular-signal-regulated-kinase-1-2-signal-pathway
#17
Wei Yan, Dan Li, Xiaoxu Zhou
Oxidative stress plays an important role in atherosclerosis, a vascular disease with high morbidity and mortality. The ETS domain-containing protein ELK1 is an oxidative stress-sensitive factor modulated by the extracellular signal-regulated kinase (ERK) 1/2 pathway. However, the role of ELK1 in the prevention of atherosclerosis by pravastatin remains unclear. In the present study, male apolipoprotein E-knockout (apoE(-/-) ) mice fed a diet containing 1.25% cholesterol (w/w) were divided into two groups, one treated with pravastatin (80 mg/kg, 2-2...
December 20, 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27988233/identification-and-functional-analysis-of-pointed-homologs-in-bombyx-mori
#18
Hiromitsu Tanaka, Aki Sagisaka
Using gene-knockdown techniques, we searched for endogenous Ets family proteins involved in the regulation of Escherichia coli-dependent lebocin promoter activation in the E. coli-responsive silkworm cell line NIAS-Bm-aff3. Results showed that the gene knockdown of BmPointeds (BmPNTs), Drosophila Pointed orthologs, enhanced E. coli-dependent lebocin promoter activation, suggesting that endogenous BmPNTs repress the activation of this promoter. Furthermore, we found that i) the BmPNT gene produced at least two alternative splicing isoforms, BmPNT1 and BmPNT2, both of which function as repressors; ii) BmPNTs were not associated with an already-reported repressor element, most proximal GGAA/T motif (EtsRE3), in lebocin promoter, which plays a role in the repression of E...
March 10, 2017: Gene
https://www.readbyqxmd.com/read/27987522/-interleukin-2-signaling-pathway-regulating-molecules-in-systemic-lupus-erythematosus
#19
Q Guo, X Y Chen, Y Su
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease, which characterized by complex immunological abnormalities and multiple tissue and organ damages. The etiology and pathogenesis of SLE have not been entirely recognized. Genetic, environmental and viral infections and other factors might be related to the pathogenetic mechanisms of SLE. Interleukin-2 (IL-2) is a critical cytokine produced by T cells upon activation and is important for the generation of T regulatory cells and activation-induced cell death...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27978596/environmental-tobacco-smoke-exposure-and-periodontitis-prevalence-among-nonsmokers-in-the-hispanic-community-health-study-study-of-latinos
#20
Aderonke A Akinkugbe, Anne E Sanders, John S Preisser, Jianwen Cai, Christian R Salazar, James D Beck
OBJECTIVE: To describe self-reported exposure to environmental tobacco smoke (ETS) and its association with periodontitis prevalence in a diverse group of Hispanics/Latinos. METHODS: Data came from 8675 lifetime nonsmokers in the 2008-2011 Hispanic Community Health Study/Study of Latinos. Exposure to ETS was self-reported, while periodontitis was defined using the Centers for Disease Control and Prevention-American Academy of Periodontology criteria and the proportion of sites affected by clinical attachment level of ≥3 mm or pocket depth of ≥4 mm...
December 15, 2016: Community Dentistry and Oral Epidemiology
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