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https://www.readbyqxmd.com/read/28731614/economic-injury-levels-and-economic-thresholds-for-leptoglossus-zonatus-dallas-hemiptera-coreidae-infesting-seed-maize
#1
Josemar Foresti, Cristina S Bastos, Flávio L Fernandes, Paulo R da Silva
BACKGROUND: Although Leptoglossus zonatus is considered a secondary pest of maize grown for grain, when grown for seed, this pest can cause significant economic damage. There are no records of management recommendations for this pest. The objectives of this work were to quantify losses caused by L. zonatus to different genotypes used for seed maize production and to estimate the acute toxicity of select insecticides to L. zonatus using different application technologies. The ultimate goal was to calculate economic injury levels (EILs) and develop economic thresholds (ETs) for L...
July 21, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28728983/etv4-and-ap1-transcription-factors-form-multivalent-interactions-with-three-sites-on-the-med25-activator-interacting-domain
#2
Simon L Currie, Jedediah J Doane, Kathryn S Evans, Niraja Bhachech, Bethany J Madison, Desmond K W Lau, Lawrence P McIntosh, Jack J Skalicky, Kathleen A Clark, Barbara J Graves
The recruitment of transcriptional cofactors by sequence-specific transcription factors challenges the basis of high affinity and selective interactions. Extending previous studies that the N-terminal activation domain (AD) of ETV5 interacts with Mediator subunit 25 (MED25), we establish that similar, aromatic-rich motifs located both in the AD and in the DNA-binding domain (DBD) of the related ETS factor ETV4 interact with MED25. These ETV4 regions bind MED25 independently, display distinct kinetics, and combine to contribute to a high-affinity interaction of full-length ETV4 with MED25...
July 17, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28726637/microrna-101-attenuates-pulmonary-fibrosis-by-inhibiting-fibroblast-proliferation-and-activation
#3
Chaoqun Huang, Xiao Xiao, Ye Yang, Amarjit Mishra, Yurong Liang, Xiangming Zeng, Xiaoyun Yang, Dao Xu, Michael R Blackburn, Craig A Henke, Lin Liu
Aberrant proliferation and activation of lung fibroblasts contribute to the initiation and progression of idiopathic pulmonary fibrosis (IPF). However, the mechanisms responsible for the proliferation and activation of fibroblasts are not fully understood. The objective of the current study was to investigate the role of miR-101 in the proliferation and activation of lung fibroblasts. miR-101 expression was determined in lung tissues from patients with IPF and mice with bleomycin-induced pulmonary fibrosis...
July 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28718926/ets-nocv-decomposition-of-the-reaction-force-the-hcn-cnh-isomerization-reaction-assisted-by-water
#4
Silvia Díaz, Mateusz Z Brela, Soledad Gutiérrez-Oliva, Alejandro Toro-Labbé, Artur Michalak
The partitioning of the reaction force based on the extended-transition-state natural orbital for chemical valence (ETS-NOCV) scheme has been proposed. This approach, together with the analysis of reaction electronic flux (REF), has been applied in a description of the changes in the electronic structure along the IRC pathway for the HCN/CNH isomerization reaction assisted by water. Two complementary ways of partitioning the system into molecular fragments have been considered ("reactant perspective" and "product perspective")...
July 18, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28716922/local-destabilization-rigid-body-and-fuzzy-docking-facilitate-the-phosphorylation-of-the-transcription-factor-ets-1-by-the-mitogen-activated-protein-kinase-erk2
#5
Andrea Piserchio, Mangalika Warthaka, Tamer S Kaoud, Kari Callaway, Kevin N Dalby, Ranajeet Ghose
Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-site) to engage and facilitate efficient site-specific phosphorylation at specific serine/threonine-proline sequences by their cognate kinases. In contrast to other MAP kinase substrates, the transcription factor Ets-1 has no canonical docking motifs, yet it is efficiently phosphorylated by the MAP kinase ERK2 at a consensus threonine site (T38). Using NMR methodology, we demonstrate that this phosphorylation is enabled by a unique bipartite mode of ERK2 engagement by Ets-1 and involves two suboptimal noncanonical docking interactions instead of a single canonical docking motif...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715417/a-hox-complex-activates-and-potentiates-the-epidermal-growth-factor-signaling-pathway-to-specify-drosophila-oenocytes
#6
Guolun Wang, Lisa Gutzwiller, David Li-Kroeger, Brian Gebelein
Hox transcription factors specify distinct cell types along the anterior-posterior axis of metazoans by regulating target genes that modulate signaling pathways. A well-established example is the induction of Epidermal Growth Factor (EGF) signaling by an Abdominal-A (Abd-A) Hox complex during the specification of Drosophila hepatocyte-like cells (oenocytes). Previous studies revealed that Abd-A is non-cell autonomously required to promote oenocyte fate by directly activating a gene (rhomboid) that triggers EGF secretion from sensory organ precursor (SOP) cells...
July 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28714930/environmental-tobacco-smoke-exposure-during-pregnancy-and-child-neurodevelopment
#7
Kinga Polanska, Anna Krol, Dorota Merecz-Kot, Danuta Ligocka, Karolina Mikolajewska, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei, Wojciech Hanke
The developing fetus is especially vulnerable to environmental toxicants, including tobacco constituents. The aim of this study was to assess the impact of environmental tobacco smoke (ETS) exposure during pregnancy on child neurodevelopment within the first two years of life. The study population consisted of 461 non-smoking pregnant women (saliva cotinine level <10 ng/mL). Maternal passive smoking was assessed based on the cotinine level in saliva analyzed by the use of high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI + MS/MS) and by questionnaire data...
July 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28705455/a-molecular-phylogeny-of-the-pacific-clade-of-cyrtandra-gesneriaceae-reveals-a-fijian-origin-recent-diversification-and-a-history-of-long-distance-dispersal
#8
Melissa A Johnson, John R Clark, Warren L Wagner, Lucinda A McDade
Cyrtandra (Gesneriaceae) is among the largest genera of flowering plants in the remote oceanic islands of the Pacific, with an estimated 175 species distributed across an area that extends from the Solomon Islands, east to the Marquesas Islands, and north to the Hawaiian Islands. The vast majority of species are single-island endemics that inhabit upland rainforests. Although previous molecular phylogenetic studies greatly advanced our understanding of the diversification of Pacific Cyrtandra, a number of uncertainties remain regarding phylogenetic relationships, divergence times, and biogeographic patterns within this large and widely dispersed group...
July 10, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28703297/neither-eosinophils-nor-neutrophils-require-atg5-dependent-autophagy-for-extracellular-dna-trap-formation
#9
Nina Germic, Darko Stojkov, Kevin Oberson, Shida Yousefi, Hans-Uwe Simon
The importance of extracellular traps (ETs) in innate immunity is well established, but the molecular mechanisms responsible for their formation remain unclear and in scientific dispute. ETs have been defined as extracellular DNA scaffolds associated with the granule proteins of eosinophils or neutrophils. They are capable of killing bacteria extracellularly. Based mainly on results with phosphoinositide 3-kinase (PI3K) inhibitors such as 3-methyladenine (3-MA) and wortmannin which are commonly used to inhibit autophagy, several groups have reported that autophagy is required for neutrophil extracellular trap (NET) formation...
July 13, 2017: Immunology
https://www.readbyqxmd.com/read/28698900/simulation-based-mastery-learning-for-endoscopy-using-the-endoscopy-training-system-a-strategy-to-improve-endoscopic-skills-and-prepare-for-the-fundamentals-of-endoscopic-surgery-fes-manual-skills-exam
#10
E Matthew Ritter, Zachary A Taylor, Kathryn R Wolf, Brenton R Franklin, Sarah B Placek, James R Korndorffer, Aimee K Gardner
INTRODUCTION: The fundamentals of endoscopic surgery (FES) program has considerable validity evidence for its use in measuring the knowledge, skills, and abilities required for competency in endoscopy. Beginning in 2018, the American Board of Surgery will require all candidates to have taken and passed the written and performance exams in the FES program. Recent work has shown that the current ACGME/ABS required case volume may not be enough to ensure trainees pass the FES skills exam...
July 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28696249/haploinsufficiency-of-the-transcription-factor-ets-1-is-renoprotective-in-dahl-salt-sensitive-rats
#11
Wenguang Feng, Bo Chen, Dongqi Xing, Xingsheng Li, Huma Fatima, Edgar A Jaimes, Paul W Sanders
Studies using Dahl salt-sensitive (SS) rats identified specific quantitative trait loci that predispose animals to hypertension-associated albuminuria and kidney injury. We explored the hypothesis that kidney-specific expression of the transcription factor Ets-1, located within one of these loci on chromosome 8, mediates glomerular injury in SS hypertension. During the first week on a high-salt diet, SS rats and SS rats with only one functioning Ets-1 gene (ES rats) demonstrated similar increases in BP. However, serum creatinine concentration, albuminuria, and glomerular expression of ETS-1 and two ETS-1 targets, MCP-1 and MMP2, did not increase as substantially in ES rats as in SS rats...
July 10, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28694332/the-ets2-repressor-factor-erf-is-required-for-effective-primitive-and-definitive-hematopoiesis
#12
Ioanna Peraki, James Palis, George Mavrothalassitis
Erf is a ubiquitously expressed ets-DNA-binding containing transcriptional repressor. Erf haploinsufficiency causes craniosynostosis in human and mice, while its absence in mice leads to failed chorioallantoic fusion and death at E10.5. In this study, we show that Erf is required in all three waves of embryonic hematopoiesis. Mice lacking Erf in embryo proper exhibited severe anemia and died around embryonic day (E) 14.5. Erf epiblast specific knockout embryos had reduced numbers of circulating blood cells from E9...
July 10, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28693791/etv6-and-etv7-siblings-in-hematopoiesis-and-its-disruption-in-disease
#13
REVIEW
Parisa Rasighaemi, Alister C Ward
ETV6 (TEL1) and ETV7 (TEL2) are closely-related members of the ETS family of transcriptional regulators. Both ETV6 and ETV7 have been demonstrated to play key roles in hematopoiesis, particularly with regard to maintenance of hematopoietic stem cells and control of lineage-specific differentiation, with evidence of functional interactions between both proteins. ETV6 has been strongly implicated in the molecular etiology of a number of hematopoietic diseases, including as a tumor suppressor, an oncogenic fusion partner, and an important regulator of thrombopoiesis, but recent evidence has also identified ETV7 as a potential oncogene in certain malignancies...
August 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28693200/sorafenib-induced-alteration-of-protein-glycosylation-in-hepatocellular-carcinoma-cells
#14
Tianhua Liu, Riqiang Liu, Shu Zhang, Kun Guo, Qinle Zhang, Wei Li, Yinkun Liu
Sorafenib is a multikinase inhibitor and is effective in treating hepatocellular carcinoma (HCC). However, it remains unknown whether sorafenib induces the alteration of protein glycosylation. The present study treated HCC MHCC97L and MHCC97H cells with a 50% inhibitory concentration of sorafenib. Following this treatment, alteration of protein glycosylation was detected using a lectin microarray. Compared with the controls, the binding capacity of glycoproteins extracted from sorafenib-treated HCC cells to the lectins Bauhinia purpurea lectin, Dolichos biflorus agglutinin, Euonymus europaeus lectin, Helix aspersa lectin, Helix pomatia lectin, Jacalin, Maclura pomifera lectin and Vicia villosa lectin were enhanced; while, the binding capacities to the lectins Caragana arborescens lectin, Lycopersicon esculentum lectin, Limulus polyphemus lectin, Maackia amurensis lecin I, Phaseolus vulgaris leucoagglutinin, Ricinus communis agglutinin 60, Sambucus nigra lectin and Solanum tuberosum lectin were reduced (spot intensity median/background intensity median ≥2, P<0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692868/single-and-mixture-impacts-of-two-pyrethroids-on-damselfly-predatory-behavior-and-physiological-biomarkers
#15
Warren Kunce, Robby Stoks, Frank Johansson
Direct mortality due to toxicity of single pesticide exposure along a concentration gradient, while the most common, is only one important parameter for assessing the effects of pesticide contamination on aquatic ecosystems. Sub-lethal toxicity can induce changes in an organism's behavior and physiology that may have population-level ramifications and consequences for ecosystem health. Additionally, the simultaneous detection of multiple contaminants in monitored watersheds stresses the importance of gaining a greater understanding of the toxicities of combined exposures, particularly at low, environmentally relevant concentrations...
June 27, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28692115/an-optimized-protocol-for-dna-extraction-in-plants-with-a-high-content-of-secondary-metabolites-based-on-leaves-of-mimosa-tenuiflora-willd-poir-leguminosae
#16
S R Arruda, D G Pereira, M M Silva-Castro, M G Brito, A M Waldschmidt
Some species are characterized by a high content of tannins, alkaloids, and phenols in their leaves. These secondary metabolites are released during DNA extraction and might hinder molecular studies based on PCR (polymerase chain reaction). To provide an efficient method to extract DNA, Mimosa tenuiflora, an important leguminous plant from Brazilian semiarid region used in popular medicine and as a source of fuelwood or forage, was used. Eight procedures previously reported for plants were tested and adapted from leaf tissues of M...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28689390/usefulness-of-end-to-side-bridging-anastomosis-of-sural-nerve-to-tibial-nerve-an-experimental-research
#17
Soner Civi, Emre Durdag, Murat Hamit Aytar, Ozgur Kardes, Figen Kaymaz, Sukru Aykol
OBJECTIVE: Repair of sensorial nerve defect is an important issue on peripheric nerve surgery. The aim of the present study was to determine the effects of sensory-motor nerve bridging on the denervated dermatomal area, in rats with sensory nerve defects, using a neural cell adhesion molecule (NCAM). METHODS: We compared the efficacy of end-to-side (ETS) coaptation of the tibial nerve for sural nerve defect repair, in 32 Sprague-Dawley rats. Rats were assigned to 1 of 4 groups: group A was the sham operated group, group B rats had sural nerves sectioned and buried in neighboring muscles, group C experienced nerve sectioning and end-to-end (ETE) anastomosis, and group D had sural nerves sectioned and ETS anastomosis was performed using atibial nerve bridge...
July 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28686110/role-of-endoscopic-transnasal-surgery-for-skull-base-chondrosarcoma-a-retrospective-analysis-of-19-cases-at-a-single-institution
#18
Hirotaka Hasegawa, Masahiro Shin, Kenji Kondo, Shunya Hanakita, Akitake Mukasa, Taichi Kin, Nobuhito Saito
OBJECTIVE Skull base chondrosarcoma is one of the most intractable tumors because of its aggressive biological behavior and involvement of the internal carotid artery and cranial nerves (CNs). One of the most accepted treatment strategies for skull base chondrosarcoma has been surgical removal of the tumor in conjunction with proactive extensive radiation therapy (RT) to the original tumor bed. However, the optimal strategy has not been determined. The goal of this study was to evaluate the early results of endoscopic transnasal surgery (ETS)...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28685869/biomarkers-of-the-alcohol-hangover-state-ethyl-glucuronide-etg-and-ethyl-sulfate-ets
#19
Marlou Mackus, Aurora J A E van de Loo, S Jorinde Raasveld, Anna Hogewoning, Javier Sastre Toraño, Frits M Flesch, Gerdien A H Korte-Bouws, Renier H P van Neer, Xiaochun Wang, Thomas T Nguyen, Karel A Brookhuis, Aletta D Kraneveld, Johan Garssen, Joris C Verster
INTRODUCTION: The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state. METHODS: Thirty-sixhealthy social drinkers participated in this study, being of naturalistic design. Eighteen participants experience regular hangovers (the hangover group), whereas the other 18 claim to not experience a hangover (the hangover-immune group). On a control day (alcohol-free) day and a post-alcohol day, urine EtG and EtS concentrations were determined and hangover severity assessed...
July 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28676594/suicide-mortality-trends-in-four-provinces-of-iran-with-the-highest-mortality-from-2006-2016
#20
Hajar Nazari Kangavari, Ahmad Shojaei, Seyed Saeed Hashemi Nazari
BACKGROUND: Suicide is a major cause of unnatural deaths in the world. Its incidence is higher in western provinces of Iran. So far, there has not been any time series analysis of suicide in western provinces. The purpose of this study was to analyze suicide mortality data from 2006 to 2016 as well as to forecast the number of suicides for 2017 in four provinces of Iran (Ilam, Kermanshah and Lorestan and Kohgiluyeh and Boyer-Ahmad). STUDY DESIGN: Descriptive-analytic study...
June 14, 2017: Journal of Research in Health Sciences
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