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https://www.readbyqxmd.com/read/27931031/round-table-discussion
#1
Susan Winter, Neil R M Buist, Nicola Longo, Saro H Armenian, Gary Lopaschuk, Anna Wasilewska
The 1st International Carnitine Working Group concluded with a round table discussion addressing several areas of relevance. These included the design of future studies that could increase the amount of evidence-based data about the role of carnitine in the treatment of fatty acid oxidation defects, for which substantial controversy still exists. There was general consensus that future trials on the effect of carnitine in disorders of fatty acid oxidation should be randomized, double-blinded, multicentered and minimally include the following diagnoses: medium-chain acyl coenzyme A (CoA) dehydrogenase deficiency, very long-chain acyl-CoA dehydrogenase deficiency, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and mitochondrial trifunctional protein deficiency...
December 9, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27901191/charcoal-anatomy-of-brazilian-species-i-anacardiaceae
#2
Thaís A P Gonçalves, Rita Scheel-Ybert
Anthracological studies are firmly advancing in the tropics during the last decades. The theoretical and methodological bases of the discipline are well established. Yet, there is a strong demand for comparative reference material, seeking for an improvement in the precision of taxonomic determination, both in palaeoecological and palaeoethnobotanical studies and to help preventing illegal charcoal production. This work presents descriptions of charcoal anatomy of eleven Anacardiaceae species from six genera native to Brazil (Anacardium occidentale, Anacardium parvifolium, Astronium graveolens, Astronium lecointei, Lithrea molleoides, Schinus terebenthifolius, Spondias mombin, Spondias purpurea, Spondias tuberosa, Tapirira guianensis, and Tapirira obtusa)...
2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27759694/an-aggressive-primary-cutaneous-follicle-center-lymphoma-with-c-myc-translocation-and-cdkn2a-9p21-deletion-a-case-report-and-review-of-the-literature
#3
Hamilton C Tsang, Susan Mathew, Cynthia M Magro
Diffuse large cell B-cell lymphoma of the skin is most commonly represented by diffuse large cell variants of primary cutaneous follicle center lymphoma and the leg-type lymphoma. In a minority of cases, the infiltrates are an expression of stage 4 disease of established extracutaneous B-cell lymphoma. We describe 1 female patient 85 years of age with an aggressive form of primary cutaneous B-cell lymphoma manifesting in multiple firm erythematous indurated solid nodules 1-2 cm each symmetrically on the face periorbitally and on the upper extremities bilaterally...
October 18, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27617527/infantile-myofibroma-a-firm-round-plaque-in-an-infant
#4
Shinya Amano, Mark Halsey, Mariko Yasuda, Patrick O'Donnell, Courtney Csikesz
Infantile myofibroma is a rare fibromatous tumor that is variable in presentation and is frequently mistaken for hemangioma or rhabdomyosarcoma. We describe a 14-month-old boy who presented with multiple, enlarging, firm lesions on the shoulder. Biopsy revealed a proliferation of small spindle cells with myxoid and hyalinized stroma infiltrating into the superficial adipose tissue. We provide a brief review of the clinical presentation, histopathologic features, management, and recent advances in our understanding of this rare condition...
May 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27601919/an-isolated-orbital-mass-with-proptosis-and-diplopia-an-uncommon-metastasis-from-intracranial-olfactory-neuroblastoma-in-a-chinese-patient
#5
Jianqin Shen, Hongguang Cui, Shi Feng
PURPOSE: Olfactory neuroblastoma (ONB) is a rare neuroectodermal malignant neoplasm that originates from the olfactory sensory epithelium. In reported cases involving the orbit, the primary neoplasms could invade the orbits through bone destruction or cranio-orbital communication anatomical structure. The present study reports a rare case of orbital metastatic tumor arising from an intracranial ONB in a Chinese patient, which is the first case demonstrating an uncommon route of ONB involving the orbit...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27345882/-the-evaluation-and-surgical-treatment-of-mass-in-the-pretracheal-space
#6
H Shen, B B Wei, Z X Peng
OBJECTIVE: To study the pathological and clinical features and the surgical results of the mass in the pretracheal space. METHODS: From 1999 to 2004, 8 females and 3 males with an average of 43 years (from 32 to 61 years) were included CT scan, nuclear imaging, ultrasound and ultrasound-guided aspiration, endoscopic and laboratory measure were used in the evaluation for the masses before operation. Complete removal of mass was carried out in all patients under general anesthesia, and continuous negative pressure draining was routinely used...
June 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27338195/what-is-asthma-copd-overlap-syndrome-towards-a-consensus-definition-from-a-round-table-discussion
#7
Don D Sin, Marc Miravitlles, David M Mannino, Joan B Soriano, David Price, Bartolome R Celli, Janice M Leung, Yasutaka Nakano, Hye Yun Park, Peter A Wark, Michael E Wechsler
Patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) have been largely excluded from pivotal therapeutic trials and, as a result, its treatment remains poorly defined and lacking firm evidence. To date, there is no universally accepted definition of ACOS, which has made it difficult to understand its epidemiology or pathophysiology. Despite many uncertainties, there is emerging agreement that some of the key features of ACOS include persistent airflow limitation in symptomatic individuals 40 years of age and older, a well-documented history of asthma in childhood or early adulthood and a significant exposure history to cigarette or biomass smoke...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27194875/a-rare-spindle-cell-variant-of-non-hodgkin-s-lymphoma-of-the-mandible
#8
N Srikant, Shanmukha Raviteja Yinti, Mohan Baliga, Hema Kini
A 64-year-old male farmer presented with a rapidly progressive swelling of the left mandible since 6 months. The swelling was firm to hard, diffuse, nontender, obliterating the vestibule with paresthesia of lower lip. The cone beam computed tomography imaging revealed an ill-defined, moth-eaten radiolucency with destruction of the buccal and lingual cortical plates. The rapid growth and aggressive behavior of the lesion coupled with guidance from the patient's previous reports from the incisional biopsy and fine needle aspiration cytology warranted a mandibular resection...
January 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27098569/physicochemical-variability-of-cambuci-fruit-campomanesia-phaea-from-a-same-orchard-from-different-locations-and-at-different-ripening-stages
#9
Maria cecÍlia Sanches Azevedo, Rafaela Rossi E Silva, Angelo Pedro Jacomino, Maria InÉs Genovese
BACKGROUND: This study evaluated the variability of cambuci fruit (Campomanesia phaea) cultivated in São Paulo State in the towns of Mogi das Cruzes, Paraibuna, Paranapiacaba, and Rio Grande da Serra, and characterized it at different maturity stages regarding size, firmness, soluble solids content, titratable acidity, phenolic content, ethylene production, respiration rate, and in vitro antioxidant capacity. RESULTS: Ripe fruit from the same locality, Paraibuna, showed large variations in size and acidity...
April 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27072732/tenosynovial-giant-cell-tumor-in-the-dermis-of-the-external-auditory-meatus
#10
Amin Maghari, Theresa A Zaleski, Tiffany Jow, W Clark Lambert
A 26-year-old African American woman with a history of a recurring "oozing papule" in the right ear presented to the emergency department in July 2010 with a 2-month history of an enlarging, painful growth in the right ear canal. Physical examination revealed a 1-cm round cystic lesion along the right, anterior external auditory canal wall, just medial to the tragus. Initial diagnosis was an infected cyst of the external ear canal. The patient was instructed to follow-up with an ear, nose, and throat (ENT) office...
2016: Skinmed
https://www.readbyqxmd.com/read/26908746/world-health-organization-s-innovative-direct-disbursement-mechanism-for-payment-of-grassroots-immunization-personnel-and-operations-in-nigeria-2004-2015
#11
Yared G Yehualashet, Alieu Wadda, Koffi B Agblewonu, Theophilus Zhema, Al-Asi A Ibrahim, Alhagie Corr, Jennifer Linkins, Pascal Mkanda, Rui G Vaz, Peter Nsubuga, Daniel Ashogbon
BACKGROUND: Following the 1988 World Health Assembly resolution to eradicate polio, the government of Nigeria, with support from partners, has been implementing several rounds of supplementary immunization activities (SIAs) each year. In addition to the technical requirements, the success of the polio eradication initiative depends on timely provision of adequate financial resources. Disbursement of funds for SIAs and payment of allowances to numerous vaccination personnel at the grassroots level are enormous operational challenges in a country the size of Nigeria...
May 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/26632798/infantile-myofibroma-a-firm-round-plaque-in-an-infant
#12
Shinya Amano, Mark Halsey, Mariko Yasuda, Patrick O'Donnell, Courtney Csikesz
Infantile myofibroma is a rare fibromatous tumor that is variable in presentation and is frequently mistaken for hemangioma or rhabdomyosarcoma. We describe a 14-month-old male who presented with multiple, enlarging, firm lesions on the shoulder. Biopsy revealed a proliferation of small spindle cells with myxoid and hyalinized stroma infiltrating into the superficial adipose tissue. We provide a brief review of the clinical presentation, histopathologic features, management and recent advances in our understanding of this rare condition...
October 2015: Dermatology Online Journal
https://www.readbyqxmd.com/read/26519526/-sclerosing-pelvic-floor-rhabdomyoma
#13
Sandra Liliana Quijano Moreno, Ana Delina Lozano Salazar, María Del Mar Berenguel Ibáñez, Ángel Reina Duarte, Ricardo Gonzales Campora
PURPOSE: This article reports on a sclerosing perineal-perianal rhabdomyoma in an adult woman. A review of the literature disclosed no reference to this histological form of rhabdomyoma in women. METHODS AND RESULTS: We describe the case of a 48-year-old woman. At physical examination, a firm nodular lesion was identified in the left lateral perianal-perineal region. Histologically, it comprised rounded and elongated muscle fibers displaying no evident atypia, within a stroma exhibiting marked sclerosis and mild lymphoid infiltrate...
April 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26181593/identification-of-ohnolog-genes-originating-from-whole-genome-duplication-in-early-vertebrates-based-on-synteny-comparison-across-multiple-genomes
#14
Param Priya Singh, Jatin Arora, Hervé Isambert
Whole genome duplications (WGD) have now been firmly established in all major eukaryotic kingdoms. In particular, all vertebrates descend from two rounds of WGDs, that occurred in their jawless ancestor some 500 MY ago. Paralogs retained from WGD, also coined 'ohnologs' after Susumu Ohno, have been shown to be typically associated with development, signaling and gene regulation. Ohnologs, which amount to about 20 to 35% of genes in the human genome, have also been shown to be prone to dominant deleterious mutations and frequently implicated in cancer and genetic diseases...
July 2015: PLoS Computational Biology
https://www.readbyqxmd.com/read/26174772/development-of-patient-derived-xenograft-models-from-a-spontaneously-immortal-low-grade-meningioma-cell-line-kci-meng1
#15
Sharon K Michelhaugh, Anthony R Guastella, Kaushik Varadarajan, Neil V Klinger, Prahlad Parajuli, Aamir Ahmad, Seema Sethi, Amro Aboukameel, Sam Kiousis, Ian M Zitron, Salah A Ebrahim, Lisa A Polin, Fazlul H Sarkar, Aliccia Bollig-Fischer, Sandeep Mittal
BACKGROUND: There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic approaches. METHODS: A primary meningioma cell line was generated from a patient with an olfactory groove meningioma. The cell line was extensively characterized by performing analysis of growth kinetics, immunocytochemistry, telomerase activity, karyotype, and comparative genomic hybridization...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26085121/ovariectomy-as-treatment-for-ovarian-bacterial-granulomas-in-a-duvaucel-s-gecko-hoplodactylus-duvaucelii
#16
A T Le Souëf, M Barry, D H Brunton, R Jakob-Hoff, B Jackson
CASE HISTORY: An adult female Duvaucel's gecko (Hoplodactylus duvaucelii) from a threatened species breeding programme presented due to a prolonged gestation period and distended abdomen. CLINICAL AND PATHOLOGICAL FINDINGS: The gecko was in lean body condition with an irregularly shaped, firm mass in the coelomic cavity. Radiographically there was a diffuse radio-opacity within the coelomic cavity with cranial displacement of the right lung field. Ultrasonography revealed a round homogenous abdominal mass of medium echogenicity with an echogenic capsule...
November 2015: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/25957763/an-extraocular-non-invasive-transscleral-led-endoilluminator-for-eye-speculum-integration
#17
Philipp Simon Kölbl, Christoph Lindner, Christian Lingenfelder, Svenja Deuchler, Pankaj Singh, Frank Koch, Martin Hessling
PURPOSE: Conventional chandelier-endoilluminators used for pars-plana vitrectomy consist of a light-emitting tip attached to an optical fibre. The tip requires introduction into the ocular space through an incision. To achieve complete illumination of the intraocular space, the introduction of more than just one tip is sometimes necessary. An extraocular vitreoretinal LED-endoilluminator discussed in this paper represents a new approach to illuminate the intraocular space. The light source is integrated into a speculum and firmly apposed to the sclera...
September 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/25914177/ossifying-fibromyxoid-tumor-report-of-a-case-with-cytomorphologic-description
#18
Omar I Ahmed, Shadi A Qasem, Ziyan T Salih
Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm with uncertain histogenesis. Most cases behave in a clinically benign fashion; however, a small percentage of tumors may locally recur or metastasize. Herein we present a case of a 56-year-old man who presented with an enlarging left groin mass, left inner thigh numbness, burning paresthesia and discomfort in his left groin. The mass sampled by fine- needle aspiration and needle core biopsy. Cytology showed bland-appearing epithelioid cells with round nuclei and fine chromatin, with fragments of fibromyxoid stroma in the background...
August 2015: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/25889083/skin-metastases-from-lung-cancer-a-case-report
#19
Laura Pajaziti, Syzana Rexhepi Hapçiu, Shkendije Dobruna, Naim Hoxha, Fisnik Kurshumliu, Artina Pajaziti
BACKGROUND: Lung cancer is one of the most frequent malignancies, with high mortality rates. It can metastasize in almost all organs, but more often invades hilar nodes, liver, adrenal glands, bones and brain. There are various data on the incidence of lung cancer metastases in the skin. In 1-12% of patients with lung cancer are developed skin metastases. Metastases in the skin may be the first sign of lung cancer. CASE PRESENTATION: Forty-five years old Albanian male, smoker, was admitted to our department with multiple nodules localized in the skin of the head, neck, back and chest...
2015: BMC Research Notes
https://www.readbyqxmd.com/read/25803736/shared-investment-projects-and-forecasting-errors-setting-framework-conditions-for-coordination-and-sequencing-data-quality-activities
#20
Stephan Leitner, Alexander Brauneis, Alexandra Rausch
In this paper, we investigate the impact of inaccurate forecasting on the coordination of distributed investment decisions. In particular, by setting up a computational multi-agent model of a stylized firm, we investigate the case of investment opportunities that are mutually carried out by organizational departments. The forecasts of concern pertain to the initial amount of money necessary to launch and operate an investment opportunity, to the expected intertemporal distribution of cash flows, and the departments' efficiency in operating the investment opportunity at hand...
2015: PloS One
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