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https://www.readbyqxmd.com/read/28431364/the-humanistic-and-economic-burden-of-dravet-syndrome-on-caregivers-and-families-implications-for-future-research
#1
REVIEW
Mark P Jensen, Andreas Brunklaus, Liam Dorris, Sameer M Zuberi, Kelly G Knupp, Bradley S Galer, Arnold R Gammaitoni
We reviewed the current literature with respect to the humanistic and financial burdens of Dravet Syndrome (DS) on the caregivers of children with DS, in order to (1) identify key unanswered questions or gaps in knowledge that need to be addressed and then, based on these knowledge gaps, (2) propose a research agenda for the scientific community to address in the coming decade. The findings support the conclusion that caring for a child with DS is associated with significant humanistic burden and direct costs...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28429987/beyond-integrated-care
#2
Thomas Plochg, Stefania Ilinca, Mirko Noordegraaf
Integrated care tops the health care agenda. But more integration alone will not remedy the crisis in health care, and there is a danger in the increasingly prevalent conceptualization of care integration as a goal in itself rather than as an instrument for improving performance. Operating integrated care systems, staffed by an overly specialized medical workforce, is unsustainable in terms of human and financial resources and is likely to produce little benefit for patients with multi-morbidity. An alternative approach involves health care leaders going beyond integrated care and nurturing transformative change from within the medical workforce instead...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28428185/investments-in-cancer-research-awarded-to-uk-institutions-and-the-global-burden-of-cancer-2000-2013-a-systematic-analysis
#3
Mahiben Maruthappu, Michael G Head, Charlie D Zhou, Barnabas J Gilbert, Majd A El-Harasis, Rosalind Raine, Joseph R Fitchett, Rifat Atun
OBJECTIVES: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs). DESIGN: Systematic analysis of all open-access data. SETTING AND PARTICIPANTS: Public and philanthropic funding to all UK cancer research institutions, 2000-2013...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28427065/emerging-simplified-retinal-imaging
#4
Ashish Sharma
Diabetic retinopathy (DR), a major microvascular complication of diabetes, has a significant impact on the world's health systems. Globally, the number of people with DR will grow from 126.6 million in 2010 to 191.0 million by 2030, and it is estimated that the number with vision-threatening diabetic retinopathy will increase from 37.3 million to 56.3 million if prompt action is not taken. Lack of early diagnosis and management is the leading cause of blindness in working-age populations The gap between demand and annual eye examinations has been a big challenge...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28426910/family-and-other-unpaid-caregivers-and-older-adults-with-and-without-dementia-and-disability
#5
Catherine Riffin, Peter H Van Ness, Jennifer L Wolff, Terri Fried
OBJECTIVES: To estimate the number of caregivers providing assistance to community-dwelling older persons with and without dementia and with or without substantial disability; to describe the characteristics of caregivers and care recipients in these groups; to characterize the health-related tasks that caregivers provide; and to estimate associations between the numbers of tasks and caregiver burden. DESIGN: Nationally representative surveys of caregivers and older adults in the United States...
April 20, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28421057/gut-microbiota-modulation-and-its-relationship-with-obesity-using-prebiotic-fibers-and-probiotics-a-review
#6
REVIEW
Dinesh K Dahiya, Renuka, Monica Puniya, Umesh K Shandilya, Tejpal Dhewa, Nikhil Kumar, Sanjeev Kumar, Anil K Puniya, Pratyoosh Shukla
In the present world scenario, obesity has almost attained the level of a pandemic and is progressing at a rapid rate. This disease is the mother of all other metabolic disorders, which apart from placing an added financial burden on the concerned patient also has a negative impact on his/her well-being and health in the society. Among the various plausible factors for the development of obesity, the role of gut microbiota is very crucial. In general, the gut of an individual is inhabited by trillions of microbes that play a significant role in host energy homeostasis by their symbiotic interactions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28414578/the-impact-of-in-home-services-utilization-on-the-institutionalization-of-older-people-in-korea
#7
Jung-Kyu Choi, Minjin Kang, Euasin Joung
As a result of aging populations, institutionalization of older people is creating an increasing financial burden in many countries. The purpose of the present study was to explore the impact of in-home services utilization on institutionalization. The subjects were newly certified as eligible for long-term care insurance between January and February 2009 in Korea. The follow-up period was 40 months to April 2012. We used logistic regression models to identify factors influencing the transition to institutional service, adjusting for gender, age, living status, income level, ADLs, and chronic disease...
April 17, 2017: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/28412517/challenges-around-access-to-and-cost-of-life-saving-medications-after-allogeneic-hematopoietic-cell-transplantation-for-medicare-patients
#8
Stephanie Farnia, Alex Ganetsky, Alicia Silver, Theresa Hwee, Jaime Preussler, Joan Griffin, Nandita Khera
Hematopoietic cell transplantation (HCT) is an expensive, medically complicated and potentially life-threatening therapy for multiple hematologic and non-hematologic disorders with a prolonged trajectory of recovery. Similar to financial issues in other cancer treatments, adverse financial consequences of HCT are emerging as an important issue, and may be associated with poor quality of life (QOL) and increased distress in HCT survivors. Prescription medicine coverage for HCT for Medicare and some Medicaid beneficiaries, especially in the long-term remains suboptimal due to inadequate payer formularies or prohibitive co-pays...
April 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28410761/impact-of-surgical-site-infection-on-healthcare-costs-and-patient-outcomes-a-systematic-review-in-six-european-countries
#9
REVIEW
J M Badia, A L Casey, N Petrosillo, P M Hudson, S A Mitchell, C Crosby
BACKGROUND: Surgical site infections (SSIs) are associated with increased morbidity and mortality. Furthermore, SSIs constitute a financial burden and negatively impact on patient quality of life (QoL). AIM: To assess, and evaluate the evidence for, the cost and health-related QoL (HRQoL) burden of SSIs across various surgical specialties in six European countries. METHODS: Electronic databases and conference proceedings were systematically searched to identify studies reporting the cost and HRQoL burden of SSIs...
March 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28407422/microbiological-diagnosis-of-device-related-biofilm-infections
#10
REVIEW
Yijuan Xu, Lone Heimann Larsen, Jan Lorenzen, Luanne Hall-Stoodley, Judith Kikhney, Annette Moter, Trine Rolighed Thomsen
Medical device-related infections cause undue patient distress, increased morbidity and mortality and pose a huge financial burden on healthcare services. The pathogens are frequently distributed heterogeneously in biofilms, which can persist without being effectively cleared by host immune defenses and antibiotic therapy. At present, there is no 'gold standard' available to reveal the presence of device-related biofilm infections. However, adequate sample collection and logistics, standardised diagnostic methods, and interpretation of results by experienced personnel are important steps in efficient diagnosis and treatment of these infections...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28406786/communication-with-physicians-about-health-care-costs-survey-of-an-insured-population
#11
Nora B Henrikson, Eva Chang, Kevin Ulrich, Deborah King, Melissa L Anderson
CONTEXT: Health care costs have increasingly shifted to patients, and financial distress caused by medical care has increased. Patients may wish to discuss costs with their clinicians. OBJECTIVE: Describe patient preferences for communication about cost in the clinical setting. DESIGN: Cross-sectional, self-administered survey of a stratified random sample of the population insured in an integrated health care system in Washington State. Our sampling frame was the entire membership aged 21 years or older...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28406053/burden-of-illness-in-systemic-lupus-erythematosus-results-from-a-uk-patient-and-carer-online-survey
#12
T Kent, A Davidson, D Newman, G Buck, D D'Cruz
Objective The objective of this study was to assess the impact of systemic lupus erythematosus (SLE) on patients and carers. Methods Adults with SLE and carers of SLE patients completed a UK-specific online survey covering many aspects of the disease. Surveys were developed in collaboration with an NHS lupus unit and a lupus patient organization. Results A total of 121 patients and 31 carers completed the surveys. Of the 70% of patients initially misdiagnosed with another condition, 59% received treatment for the misdiagnosis...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28405986/assessment-of-compliance-to-treatment-of-diabetes-and-hypertension-amongst-previously-diagnosed-patients-from-rural-community-of-raigad-district-of-maharashtra
#13
Kiranmayi Venkata Kakumani, Prasad Waingankar
INTRODUCTION: Substantial burden of diabetes and hypertension is on rise in India, leading to a twin epidemic. India, being a rural country, has unique problems regarding the treatment compliance which is a serious risk for morbidity and mortality. OBJECTIVE: To assess the compliance to treatment of hypertension and diabetes amongst the diagnosed patients from rural area and to study reasons of non-compliance and knowledge and attitude. MATERIAL AND METHODS: Community based, cross sectional, observational study conducted in the rural communities of Tara and Barapada villages of Raigad district of Maharashtra...
December 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28405540/markedly-improved-success-rate-of-endoscopically-assisted-third-ventriculostomy-is-achieved-by-routine-placement-of-external-lumbar-drain
#14
Justen Watkins, Marc Cabanne, Dan Miulli
Hydrocephalus is a major cause of patient decreased quality of life and high health care financial burden in the United States and throughout the world. The placement of ventricular shunts (ventriculoperitoneal shunt) has proven to be a safe treatment for hydrocephalus, but it is associated with a high complication rate leading to a lower quality of life and continued financial burden for patients, their families, and society as a whole. The endoscopically assisted third ventriculostomy (ETV) has been practiced as an alternative to ventricular shunting since the 1990s...
April 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28404097/hepatitis-b-and-hepatitis-c-in-southeast-and-southern-asia-challenges-for-governments
#15
Suzanne Wait, Emily Kell, Saeed Hamid, David H Muljono, Jose Sollano, Rosmawati Mohamed, Samir Shah, Mamun-Al-Mahtab, Zaigham Abbas, Jennifer Johnston, Tawesak Tanwandee, Jack Wallace
In 2015, the Coalition to Eradicate Viral Hepatitis in Asia Pacific gathered leading hepatitis experts from Bangladesh, India, Indonesia, Malaysia, Pakistan, the Philippines, and Thailand to discuss common challenges to the burden posed by hepatitis B virus (HBV) and hepatitis C virus (HCV), to learn from each other's experience, and identify sustainable approaches. In this report, we summarise these discussions. Countries differ in their policy responses to HBV and HCV; however, substantial systemic, cultural, and financial barriers to achievement of elimination of these infections persist in all countries...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403082/metronomic-oral-cyclosphosphamide-as-third-line-systemic-treatment-or-beyond-in-patients-with-inoperable-locoregionally-advanced-recurrent-or-metastatic-nasopharyngeal-carcinoma
#16
Victor H F Lee, Dora L W Kwong, Ka-On Lam, Yu-Ching Lai, Yun Li, Chi-Chung Tong, Patty P Y Ho, Wing-Lok Chan, Lai-San Wong, Dennis K C Leung, Sum-Yin Chan, Fong-Ting Chan, To-Wai Leung, Anne W M Lee
There is no standard third-line or further systemic treatment for patients with inoperable locoregionally advanced recurrent or metastatic nasopharyngeal carcinoma (NPC). Metronomic oral cyclophosphamide provides an acceptable and cheap option for these heavily pretreated patients who had limited choices. We conducted a prospective phase II single-arm open-label study of metronomic oral cyclophosphamide. Patients with locoregionally advanced recurrent inoperable (rT3/T4, rN2-N3b) or metastatic (rM1) NPC who had Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0-2) and had progressed after at least 2 lines of palliative systemic chemotherapy were eligible...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402825/inequality-and-the-health-care-system-in-the-usa
#17
REVIEW
Samuel L Dickman, David U Himmelstein, Steffie Woolhandler
Widening economic inequality in the USA has been accompanied by increasing disparities in health outcomes. The life expectancy of the wealthiest Americans now exceeds that of the poorest by 10-15 years. This report, part of a Series on health and inequality in the USA, focuses on how the health-care system, which could reduce income-based disparities in health, instead often exacerbates them. Other articles in this Series address population health inequalities, and the health effects of racism, mass incarceration, and the Affordable Care Act (ACA)...
April 8, 2017: Lancet
https://www.readbyqxmd.com/read/28398993/prevention-of-hiv-in-adolescent-girls-and-young-women-key-to-an-aids-free-generation
#18
Quarraisha Abdool Karim, Cheryl Baxter, Deborah Birx
The Global Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive (Global Plan) has ensured that more infants in high-HIV burden countries survive childhood HIV-free. Although equal numbers of boy and girl children have survived to age 10, a gender divergence starts to emerge as they enter adolescence. Up to 3 times as many young women aged 15-24 years in eastern and southern Africa are living with HIV compared with their male peers. Further, more adolescent girls and young women are sick and/or dying from AIDS-related or HIV-related complications during pregnancy and in the postpartum period, underscoring the importance of strengthening HIV treatment and prevention services for this group...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28397097/blood-brain-barriers-in-obesity
#19
Elizabeth M Rhea, Therese S Salameh, Aric F Logsdon, Angela J Hanson, Michelle A Erickson, William A Banks
After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden. Obesity is associated with serious negative health outcomes such as cardiovascular disease, type II diabetes, and, more recently, cognitive decline and various neurodegenerative dementias such as Alzheimer's disease. In the past decade, major advancements have contributed to the understanding of the role of the central nervous system (CNS) in the development of obesity and how peripheral hormonal signals modulate CNS regulation of energy homeostasis...
April 10, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28395428/-misdiagnosis-and-associated-costs-of-benign-paroxysmal-positional-vertigo
#20
S X Qian, F Li, J H Zhuang, Y Chen, H L Yang, X W Zhou, H H Gu, B Gao
Objective: The aims of this study were to investigate the misdiagnosis of benign paroxysmal positional vertigo (BPPV) and to estimate the associated costs. Methods: During October 2015 to December 2015, eighty patients were diagnosed with BPPV in the outpatient dizziness clinic of Shanghai Changzheng Hospital and the clinical data of all the 80 patients were collected including the demographic and clinical characteristics, the history of diagnosis, inappropriate diagnostic tests, costs of the medical tests, transportation and accommodation...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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