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metabolic changes post bariatric surgery

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https://www.readbyqxmd.com/read/29899081/major-microbiota-dysbiosis-in-severe-obesity-fate-after-bariatric-surgery
#1
Judith Aron-Wisnewsky, Edi Prifti, Eugeni Belda, Farid Ichou, Brandon D Kayser, Maria Carlota Dao, Eric O Verger, Lyamine Hedjazil, Jean-Luc Bouillot, Jean-Marc Chevallier, Nicolas Pons, Emmanuelle Le Chatelier, Florence Levenez, Stanislav Dusko Ehrlich, Joel Dore, Jean-Daniel Zucker, Karine Clément
OBJECTIVES: Decreased gut microbial gene richness (MGR) and compositional changes are associated with adverse metabolism in overweight or moderate obesity, but lack characterisation in severe obesity. Bariatric surgery (BS) improves metabolism and inflammation in severe obesity and is associated with gut microbiota modifications. Here, we characterised severe obesity-associated dysbiosis (ie, MGR, microbiota composition and functional characteristics) and assessed whether BS would rescue these changes...
June 13, 2018: Gut
https://www.readbyqxmd.com/read/29883055/association-of-circulating-pro-inflammatory-marker-leucine-rich-%C3%AE-2-glycoprotein-lrg1-with-obesity-and-changes-following-metabolic-bariatric-surgery
#2
Sharon Li Ting Pek, Anton Kui Sing Cheng, Michelle Xueqin Lin, Moh Sim Wong, Eric Chan Zit Liang, Angela Mei Chung Moh, Chee Fang Sum, Su Chi Lim, Subramaniam Tavintharan
OBJECTIVE: Obesity confers substantial excess risk for morbidity and mortality, especially for Type 2 diabetes (T2D). Leucine-Rich-α2-Glycoprotein 1 (LRG1), a novel pro-inflammatory factor, was recently reported to be higher in patients with T2D with complications of peripheral arterial disease. Association of LRG1, obesity and weight loss is unknown. We examined whether plasma LRG1 is associated with obesity in health screening participants and if it predicts future weight loss in morbidly obese patients after metabolic/bariatric surgery...
June 8, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29881628/improved-physiology-and-metabolic-flux-after-roux-en-y-gastric-bypass-is-associated-with-temporal-changes-in-the-circulating-micrornaome-a-longitudinal-study-in-humans
#3
Abdullah Alkandari, Hutan Ashrafian, Thozhukat Sathyapalan, Peter Sedman, Ara Darzi, Elaine Holmes, Thanos Athanasiou, Stephen L Atkin, Nigel J Gooderham
Background: The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. MicroRNAs are small, endogenous RNAs that regulate gene expression post-transcriptionally, controlling most of the human transcriptome and contributing to the regulation of systemic metabolism. This preliminary, longitudinal, repeat sampling study, in which subjects acted as their own control, aimed to assess the temporal effect of bariatric surgery on circulating microRNA expression profiles...
2018: BMC Obesity
https://www.readbyqxmd.com/read/29795464/gut-hormone-release-after-gastric-bypass-depends-on-the-length-of-the-biliopancreatic-limb
#4
Bárbara G Patrício, Tiago Morais, Marta Guimarães, Simon Veedfald, Bolette Hartmann, Linda Hilsted, Jens J Holst, Mário Nora, Mariana P Monteiro
BACKGROUND/OBJECTIVES: Changes in gut hormone secretion are important for the anti-diabetic effects of bariatric surgery. Roux-en-Y gastric bypass (RYGB) with extended biliopancreatic limb (BPL) length may improve the metabolic outcomes when compared to the classical procedure. The purpose of this study was to compare the gut hormone responses to a liquid mixed meal after RYGB with one of two different BPL lengths. SUBJECTS/METHODS: Non-diabetic weight-stable individuals previously submitted to classical RYGB (n = 9; BPL length: 87...
May 24, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29790128/evidence-that-the-length-of-bile-loop-determines-serum-bile-acid-concentration-and-glycemic-control-after-bariatric-surgery
#5
Adriana Mika, Lukasz Kaska, Monika Proczko-Stepaniak, Agnieszka Chomiczewska, Julian Swierczynski, Ryszard T Smolenski, Tomasz Sledzinski
BACKGROUND: Bariatric surgery contributes to the improvement in glucose metabolism that may be related to a postoperative increase in serum bile acids (BAs). Three commonly used types of bariatric procedures, laparoscopic sleeve gastrectomy (LSG) (without creation of a bile loop), Roux-en-Y gastric bypass (RYGB), and omega-loop gastric bypass (OLGB) (with creation of shorter 100-150 cm and longer 200-280 cm bile loops, respectively), differ in their effects on glycemic control. The aim of the study was to compare the effects of various bariatric procedures on serum BA concentration and glucose homeostasis...
May 22, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29781044/sleeve-gastrectomy-in-morbidly-obese-hiv-patients-focus-on-anti-retroviral-treatment-absorption-after-surgery
#6
Chloé Amouyal, Marion Buyse, Lea Lucas-Martini, Déborah Hirt, Laurent Genser, Adriana Torcivia, Jean-Luc Bouillot, Jean-Michel Oppert, Judith Aron-Wisnewsky
CONTEXT: Anti-retroviral therapy (ART) dramatically reduced AIDS development, thus enabling patients to live as long as the general population. New challenges have emerged particularly cardiometabolic diseases and weight gain, with some HIV patients seeking bariatric surgery (BS). However, BS outcomes during HIV remain poorly described, with scarce data on ART pharmacokinetic post-BS. OBJECTIVE: Describing sleeve gastrectomy (SG) results in HIV patients in terms of ART pharmacokinetic, HIV control, weight loss, and metabolic outcomes...
May 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29754264/one-year-impact-of-bariatric-surgery-on-serum-anti-mullerian-hormone-levels-in-severely-obese-women
#7
Clara Vincentelli, Marie Maraninchi, René Valéro, Sophie Béliard, Flavia Maurice, Olivier Emungania, Bruno Berthet, Elise Lombard, Anne Dutour, Bénédicte Gaborit, Blandine Courbiere
INTRODUCTION: Although bariatric surgery seems to increase spontaneous fertility by improving ovulatory function in young women, its impact on ovarian reserve remains largely unknown. OBJECTIVE: To evaluate changes in serum anti-Mullerian hormone (AMH) levels in reproductive-age severely obese women after bariatric surgery (BS). METHODS: AMH levels were measured retrospectively in 39 women (mean age 34.6 ± 1.1 years, range 18-45) that underwent a sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) at baseline, and 6 and 12 months after BS...
May 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29696574/optimising-the-bariatric-patients-outcome-through-cardiac-rehabilitation-approach
#8
Nor Hanim Mohamad Hanapi, Brenda Saria Yuliawiratman, Lee Lee Lai, Hazwani Halil, J G Koo, Anwar Suhaimi
Bariatric surgery offers a therapeutic alternative with favourable weight management, cardiovascular, metabolic and functional outcomes. Bariatric individuals often have functional impairments pre-operatively that can be addressed to improve post-operative results and eventual functional independence. Multidisciplinary team offers the best approach to address peri-operative needs and sustainable weight loss thereafter. We exemplified the application of cardiac rehabilitation therapeutic model in managing two bariatric clients with specific bariatric-related challenges...
April 26, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29628405/resting-metabolic-rate-and-weight-loss-after-bariatric-surgery
#9
Roberto de Cleva, Filippe Camarotto Mota, Alexandre Vieira Gadducci, Lilian Cardia, Julia Maria D'Andréa Greve, Marco Aurelio Santo
BACKGROUND: There is an increased interest in understanding how variation in body composition (BC) and energy expenditure is related to successful weight loss after surgery. It has been suggested that low resting metabolic rate (RMR) could be associated with poor weight loss. OBJECTIVES: To determine the relation among changes in BC, RMR, and weight loss after bariatric surgery. SETTING: University tertiary care hospital, Brazil. METHODS: A cohort of 45 patients submitted to bariatric surgery was prospectively studied...
March 1, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29491490/obesity-related-acetylcholinesterase-elevation-is-reversed-following-laparoscopic-sleeve-gastrectomy
#10
Shani Shenhar-Tsarfaty, Shiri Sherf-Dagan, Galia Berman, Muriel Webb, Asnat Raziel, Andrei Keidar, David Goitein, Nasser Sakran, Eti Zwang, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Oren Shibolet, Shira Zelber-Sagi
BACKGROUND: Impaired sympathetic/parasympathetic response, expressed by elevated Acetylcholinesterase (AChE) is associated with obesity, metabolic syndrome and inflammation. However, the association between morbid obesity and AChE and the changes in cholinergic tone following bariatric laparoscopic sleeve gastrectomy (LSG) surgery-induced weight reduction were never analyzed. METHODS: Two studies are presented; the first (the "apparently healthy cohort") was a cross-sectional study and the second (the "LSG cohort") was a prospective-cohort study with 12 months of follow-up...
February 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29413971/-gear-mechanism-of-bariatric-interventions-revealed-by-untargeted-metabolomics
#11
Paulina Samczuk, Magdalena Luba, Joanna Godzien, Annalaura Mastrangelo, Hady Razak Hady, Jacek Dadan, Coral Barbas, Maria Gorska, Adam Kretowski, Michal Ciborowski
Mechanisms responsible for metabolic gains after bariatric surgery are not entirely clear. The purpose of this study was evaluation of metabolic changes after laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy in semi-annual follow up. The study participants were selected from obese patients with T2DM who underwent one of the mentioned bariatric procedures. Serum metabolic fingerprinting by use of liquid and gas chromatography with mass spectrometry detection was performed on samples obtained from studied patients before, one, and six months post-surgery...
March 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29351394/bile-acid-profiles-within-the-enterohepatic-circulation-in-a-diabetic-rat-model-after-bariatric-surgeries
#12
Meng Wei, Yi Shao, Qiao-Ran Liu, Qun-Zheng Wu, Xiang Zhang, Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, San-Yuan Hu
Bile acids (BAs), which are synthesized in the liver and cycled in the enterohepatic circulation, have been recognized as signaling molecules by activating their receptors in the intestine and liver. Serum taurine-conjugated BAs have been shown to be elevated after bariatric surgeries although the postoperative BA profiles within the enterohepatic circulation have not been investigated. Clarification of these profiles could help explain the mechanisms by which bariatric surgery leads to BA profile alterations and subsequent metabolic effects...
May 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#13
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
April 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29117619/development-of-obesity-associated-comorbidities-post-bariatric-surgery-with-a-special-focus-on-diabetes-remission-and-short-term-relapse
#14
Nina Riedel, Anne Lautenbach, Jan Wilhelm Wienecke, Oliver Mann, Jörg Flitsch, Jens Aberle
Purpose The purpose of this study is to study a heterogeneous group of obese patients undergoing Bariatric surgery(BS) and its impact on glycemic control. Secondary endpoints include changes in lipid profile and albuminuria. BS has shown to effectively reduce body-weight. However, the impact on obesity-related comorbidities varies strongly between individuals. Especially postoperative short- and long-term improvement of Diabetes is an active area of investigation. Methods We conducted a retrospective analysis from baseline to 24 months post bariatric surgery in our interdisciplinary obesity outpatient-clinic...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29098545/non-alcoholic-fatty-liver-disease-in-morbidly-obese-individuals-undergoing-bariatric-surgery-prevalence-and-effect-of-the-pre-bariatric-very-low-calorie-diet
#15
Katherine J P Schwenger, Sandra E Fischer, Timothy D Jackson, Allan Okrainec, Johane P Allard
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 75 to 100% of the patients undergoing bariatric surgery (BSx), with non-alcoholic steatohepatitis (NASH) being present in 24 to 98% of the patients. We do not know whether these rates were before or after a very low calorie diet (VLCD) often prescribed before laparoscopic BSx and what is the prevalence of NAFLD post-VLCD. PURPOSE: The purpose of this study is to determine the prevalence of simple steatosis (SS) and NASH in obese individuals undergoing BSx post-VLCD and assess biochemical markers pre- and post-VLCD in a subgroup of patients...
April 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29071108/the-effect-of-bariatric-surgery-on-serum-25-oh-vitamin-d-levels-a-systematic-review-and-meta-analysis
#16
A Kalani, H Bami, M Tiboni, R Jaeschke, J D Adachi, A N Lau
BACKGROUND: Concerns have emerged about post-operative decreases in calcium and vitamin D following bariatric surgery. This review explores changes in metabolic bone health in persons with obesity undergoing gastric bypass surgery compared to non-surgical controls, providing an updated and comprehensive perspective on the literature. METHODS: An electronic search was conducted in MEDLINE, Pubmed, EMBASE and Cochrane databases to 8 November 2016. Eligible trials included randomized controlled trials or controlled observational studies of patients who have undergone laparoscopic gastric bypass surgery...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29065430/lipidomic-changes-in-skeletal-muscle-in-patients-after-biliopancreatic-diversion
#17
Carola Sabine Mehnert, Juergen Graessler, Virginia Kamvissi-Lorenz, Lidia Castagneto Gissey, James R Casella Mariolo, Giovanni Casella, Geltrude Mingrone, Stefan R Bornstein
The mechanisms behind the fast improvements of insulin sensitivity and release of the diabetic metabolic state after bariatric surgery are still not completely understood. To further elucidate the effects on the individual cellular level, we applied mass spectrometry to investigate the changes in the lipidomic profile of skeletal muscle cells before and after biliopancreatic diversion in six patients. We found a decrease in lipid storage species, mainly triacylglycerides (e. g., TAG 52:2 from 19.84 to 13...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29064512/adiponectin-promoter-polymorphisms-are-predictors-of-lipid-profile-improvement-after-bariatric-surgery
#18
Aline Simas Gasparotto, Diego Olschowsky Borges, Marília Remuzzi Zandoná, Mauricio Jacques Ramos, Nelson Guardiola Meihnardt, Vanessa S Mattevi
Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5' regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes...
October 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29040429/the-role-of-glp-1-in-the-metabolic-success-of-bariatric-surgery
#19
REVIEW
Chelsea R Hutch, Darleen Sandoval
Two of the most popular bariatric procedures, vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), are commonly considered metabolic surgeries because they are thought to affect metabolism in a weight loss-independent manner. In support of this classification, improvements in glucose homeostasis, insulin sensitivity, and even discontinuation of type 2 diabetes mellitus (T2DM) medication can occur before substantial postoperative weight loss. The mechanisms that underlie this effect are unknown...
December 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28751961/effect-of-bariatric-surgery-on-adiposity-and-metabolic-profiles-a-prospective-cohort-study-in-middle-eastern-patients
#20
Mohsen Mazidi, Peyman Rezaie, Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Andre Pascal Kengne, Mohsen Nematy
AIM: To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity. METHODS: This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year. RESULTS: Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m2 between baseline and 12-mo follow-up, while mean fat mass decreased by 45...
July 15, 2017: World Journal of Diabetes
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