Yuying Zhang, Chenye Shi, Haifu Wu, Hongmei Yan, Mingfeng Xia, Heng Jiao, Di Zhou, Wei Wu, Ming Zhong, Wenhui Lou, Xin Gao, Hua Bian, Xinxia Chang
Bariatric surgery (BS), recognized as the most effective intervention for morbid obesity and associated metabolic comorbidities, encompasses both weight loss-dependent and weight loss-independent mechanisms to exert its metabolic benefits. In this study, we employed plasma proteomics technology, a recently developed mass spectrometric approach, to quantitatively assess 632 circulating proteins in a longitudinal cohort of 9 individuals who underwent sleeve gastrectomy (SG). Through time series clustering and Gene Ontology (GO) enrichment analysis, we observed that complement activation, proteolysis, and negative regulation of triglyceride catabolic process were the primary biological processes enriched in down-regulated proteins...
2024: Frontiers in Endocrinology