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metabolic changes post bariatric surgery

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https://www.readbyqxmd.com/read/29628405/resting-metabolic-rate-and-weight-loss-after-bariatric-surgery
#1
Roberto de Cleva, Filippe Camarotto Mota, Alexandre Vieira Gadducci, Lilian Cardia, Julia Maria D'Andréa Greve, Marco Aurelio Santo
BACKGROUND: There is an increased interest in understanding how variation in body composition (BC) and energy expenditure is related to successful weight loss after surgery. It has been suggested that low resting metabolic rate (RMR) could be associated with poor weight loss. OBJECTIVES: To determine the relation among changes in BC, RMR, and weight loss after bariatric surgery. SETTING: University tertiary care hospital, Brazil. METHODS: A cohort of 45 patients submitted to bariatric surgery was prospectively studied...
March 1, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29491490/obesity-related-acetylcholinesterase-elevation-is-reversed-following-laparoscopic-sleeve-gastrectomy
#2
Shani Shenhar-Tsarfaty, Shiri Sherf-Dagan, Galia Berman, Muriel Webb, Asnat Raziel, Andrei Keidar, David Goitein, Nasser Sakran, Eti Zwang, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Oren Shibolet, Shira Zelber-Sagi
BACKGROUND: Impaired sympathetic/parasympathetic response, expressed by elevated Acetylcholinesterase (AChE) is associated with obesity, metabolic syndrome and inflammation. However, the association between morbid obesity and AChE and the changes in cholinergic tone following bariatric laparoscopic sleeve gastrectomy (LSG) surgery-induced weight reduction were never analyzed. METHODS: Two studies are presented; the first (the "apparently healthy cohort") was a cross-sectional study and the second (the "LSG cohort") was a prospective-cohort study with 12 months of follow-up...
February 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29413971/-gear-mechanism-of-bariatric-interventions-revealed-by-untargeted-metabolomics
#3
Paulina Samczuk, Magdalena Luba, Joanna Godzien, Annalaura Mastrangelo, Hady Razak Hady, Jacek Dadan, Coral Barbas, Maria Gorska, Adam Kretowski, Michal Ciborowski
Mechanisms responsible for metabolic gains after bariatric surgery are not entirely clear. The purpose of this study was evaluation of metabolic changes after laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy in semi-annual follow up. The study participants were selected from obese patients with T2DM who underwent one of the mentioned bariatric procedures. Serum metabolic fingerprinting by use of liquid and gas chromatography with mass spectrometry detection was performed on samples obtained from studied patients before, one, and six months post-surgery...
January 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29351394/bile-acid-profiles-within-the-enterohepatic-circulation-in-a-diabetic-rat-model-after-bariatric-surgeries
#4
Meng Wei, Yi Shao, Qiao-Ran Liu, Qun-Zheng Wu, Xiang Zhang, Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, San-Yuan Hu
Bile acids (BAs), which are synthesized in the liver and cycled in the enterohepatic circulation, have been recognized as signaling molecules by activating their receptors in the intestine and liver. Serum taurine-conjugated BAs have been shown to be elevated after bariatric surgeries, although the postoperative BA profiles within the enterohepatic circulation have not been investigated. Clarification of these profiles could help explain the mechanisms by which bariatric surgery leads to BA profile alterations and subsequent metabolic effects...
December 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#5
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
April 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29117619/development-of-obesity-associated-comorbidities-post-bariatric-surgery-with-a-special-focus-on-diabetes-remission-and-short-term-relapse
#6
Nina Riedel, Anne Lautenbach, Jan Wilhelm Wienecke, Oliver Mann, Jörg Flitsch, Jens Aberle
Purpose The purpose of this study is to study a heterogeneous group of obese patients undergoing Bariatric surgery(BS) and its impact on glycemic control. Secondary endpoints include changes in lipid profile and albuminuria. BS has shown to effectively reduce body-weight. However, the impact on obesity-related comorbidities varies strongly between individuals. Especially postoperative short- and long-term improvement of Diabetes is an active area of investigation. Methods We conducted a retrospective analysis from baseline to 24 months post bariatric surgery in our interdisciplinary obesity outpatient-clinic...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29098545/non-alcoholic-fatty-liver-disease-in-morbidly-obese-individuals-undergoing-bariatric-surgery-prevalence-and-effect-of-the-pre-bariatric-very-low-calorie-diet
#7
Katherine J P Schwenger, Sandra E Fischer, Timothy D Jackson, Allan Okrainec, Johane P Allard
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects 75 to 100% of the patients undergoing bariatric surgery (BSx), with non-alcoholic steatohepatitis (NASH) being present in 24 to 98% of the patients. We do not know whether these rates were before or after a very low calorie diet (VLCD) often prescribed before laparoscopic BSx and what is the prevalence of NAFLD post-VLCD. PURPOSE: The purpose of this study is to determine the prevalence of simple steatosis (SS) and NASH in obese individuals undergoing BSx post-VLCD and assess biochemical markers pre- and post-VLCD in a subgroup of patients...
November 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29071108/the-effect-of-bariatric-surgery-on-serum-25-oh-vitamin-d-levels-a-systematic-review-and-meta-analysis
#8
A Kalani, H Bami, M Tiboni, R Jaeschke, J D Adachi, A N Lau
BACKGROUND: Concerns have emerged about post-operative decreases in calcium and vitamin D following bariatric surgery. This review explores changes in metabolic bone health in persons with obesity undergoing gastric bypass surgery compared to non-surgical controls, providing an updated and comprehensive perspective on the literature. METHODS: An electronic search was conducted in MEDLINE, Pubmed, EMBASE and Cochrane databases to 8 November 2016. Eligible trials included randomized controlled trials or controlled observational studies of patients who have undergone laparoscopic gastric bypass surgery...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29065430/lipidomic-changes-in-skeletal-muscle-in-patients-after-biliopancreatic-diversion
#9
Carola Sabine Mehnert, Juergen Graessler, Virginia Kamvissi-Lorenz, Lidia Castagneto Gissey, James R Casella Mariolo, Giovanni Casella, Geltrude Mingrone, Stefan R Bornstein
The mechanisms behind the fast improvements of insulin sensitivity and release of the diabetic metabolic state after bariatric surgery are still not completely understood. To further elucidate the effects on the individual cellular level, we applied mass spectrometry to investigate the changes in the lipidomic profile of skeletal muscle cells before and after biliopancreatic diversion in six patients. We found a decrease in lipid storage species, mainly triacylglycerides (e. g., TAG 52:2 from 19.84 to 13...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29064512/adiponectin-promoter-polymorphisms-are-predictors-of-lipid-profile-improvement-after-bariatric-surgery
#10
Aline Simas Gasparotto, Diego Olschowsky Borges, Marília Remuzzi Zandoná, Mauricio Jacques Ramos, Nelson Guardiola Meihnardt, Vanessa S Mattevi
Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5' regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes...
October 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29040429/the-role-of-glp-1-in-the-metabolic-success-of-bariatric-surgery
#11
REVIEW
Chelsea R Hutch, Darleen Sandoval
Two of the most popular bariatric procedures, vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), are commonly considered metabolic surgeries because they are thought to affect metabolism in a weight loss-independent manner. In support of this classification, improvements in glucose homeostasis, insulin sensitivity, and even discontinuation of type 2 diabetes mellitus (T2DM) medication can occur before substantial postoperative weight loss. The mechanisms that underlie this effect are unknown...
December 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28751961/effect-of-bariatric-surgery-on-adiposity-and-metabolic-profiles-a-prospective-cohort-study-in-middle-eastern-patients
#12
Mohsen Mazidi, Peyman Rezaie, Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Andre Pascal Kengne, Mohsen Nematy
AIM: To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity. METHODS: This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year. RESULTS: Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m2 between baseline and 12-mo follow-up, while mean fat mass decreased by 45...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28673470/differential-acute-and-chronic-responses-in-insulin-action-in-cultured-myotubes-following-from-nondiabetic-severely-obese-humans-following-gastric-bypass-surgery
#13
J Matthew Hinkley, Kai Zou, Sanghee Park, Donghai Zheng, G Lynis Dohm, Joseph A Houmard
BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery has been shown to induce positive metabolic adaptations for individuals with severe obesity (body mass index ≥40 kg/m(2)), including improved peripheral insulin action. Although a major site of insulin action, the time course changes in skeletal muscle glucose metabolism following RYGB is unclear. OBJECTIVES: To investigate the acute and chronic effects of RYGB surgery on insulin-stimulated glucose metabolism in cultured human primary myotubes derived from nondiabetic severely obese humans...
November 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28649469/distinct-patterns-in-the-gut-microbiota-after-surgical-or-medical-therapy-in-obese-patients
#14
Daniel A Medina, Juan P Pedreros, Dannae Turiel, Nicolas Quezada, Fernando Pimentel, Alex Escalona, Daniel Garrido
Bariatric surgery is highly successful in improving health compared to conventional dietary treatments. It has been suggested that the gut microbiota is a relevant factor in weight loss after bariatric surgery. Considering that bariatric procedures cause different rearrangements of the digestive tract, they probably have different effects on the gut microbiota. In this study, we compared the impact of medical treatment, sleeve gastrectomy and Roux-en-Y gastric bypass on the gut microbiota from obese subjects...
2017: PeerJ
https://www.readbyqxmd.com/read/28548658/distinctive-microbiomes-and-metabolites-linked-with-weight-loss-after-gastric-bypass-but-not-gastric-banding
#15
Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown
Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are anatomically different bariatric operations. RYGB achieves greater weight loss compared with LAGB. Changes in the gut microbiome have been documented after RYGB, but not LAGB, and the microbial contribution to sustainable surgical weight loss warrants further evaluation. We hypothesized that RYGB imposes greater changes on the microbiota and its metabolism than LAGB, and that the altered microbiota may contribute to greater weight loss...
September 2017: ISME Journal
https://www.readbyqxmd.com/read/28444860/aspirin-responsiveness-changes-in-obese-patients-following-bariatric-surgery
#16
Nicholas B Norgard, Scott V Monte, Stanley F Fernandez, Qing Ma
AIMS: Bariatric surgery has emerged as a promising treatment option for weight loss and to counter the metabolic consequences of obesity. Obesity has been linked to a hyperaggregable state, as well as a blunted response to aspirin. This pilot study assessed the hypothesis that bariatric surgery would lead to an improvement in aspirin-induced platelet inhibition and a reduction in platelet aggregability. METHODS: Fifteen patients scheduled to undergo bariatric surgery were administered two 7-day courses of aspirin 81 mg: the first course administered before surgery and the second was 3 months following surgery...
August 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28429404/air-pollution-weight-loss-and-metabolic-benefits-of-bariatric-surgery-a-potential-model-for-study-of-metabolic-effects-of-environmental-exposures
#17
R Ghosh, W J Gauderman, H Minor, H A Youn, F Lurmann, K R Cromar, L Chatzi, B Belcher, C R Fielding, R McConnell
BACKGROUND: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. OBJECTIVES: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. METHODS: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA1c ) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB)...
April 21, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28299572/early-weight-loss-independent-effects-of-sleeve-gastrectomy-on-diet-induced-cardiac-dysfunction-in-obese-wistar-rats
#18
Tammy L Kindel, Tom Foster, Paul Goldspink, Steven J Kindel, John Corbett, Michael Widlanksy, Jennifer Strande
INTRODUCTION: Several reports suggest that bariatric surgery significantly improves cardiac function in patients with obesity cardiomyopathy. The mechanism is unknown but may be due to weight-loss independent factors. We predict that the changes in gastrointestinal anatomy after a rodent model of sleeve gastrectomy (SG) will have weight-loss independent effects on cardiac dysfunction. METHODOLOGY: Cardiac dysfunction was induced by feeding a 60% kcal from fat diet to male Wistar rats for 10 weeks...
September 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28258704/non-alcoholic-fatty-liver-disease-phosphoproteomics-a-functional-piece-of-the-precision-puzzle
#19
Julia Wattacheril, Kristie L Rose, Salisha Hill, Christian Lanciault, Clark R Murray, Kay Washington, Brandon Williams, Wayne English, Matthew Spann, Ronald Clements, Naji Abumrad, Charles Robb Flynn
BACKGROUND: Molecular signaling events associated with the necroinflammatory changes in nonalcoholic steatohepatitis (NASH) are not well understood. AIMS: To understand the molecular basis of NASH, we evaluated reversible phosphorylation events in hepatic tissue derived from Class III obese subjects by phosphoproteomic means with the aim of highlighting key regulatory pathways that distinguish NASH from non-alcoholic fatty liver disease (also known as simple steatosis; SS)...
December 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28202005/impact-of-gut-hormone-fgf-19-on-type-2-diabetes-and-mitochondrial-recovery-in-a-prospective-study-of-obese-diabetic-women-undergoing-bariatric-surgery
#20
Lucia Martinez de la Escalera, Ioannis Kyrou, Jana Vrbikova, Voitech Hainer, Petra Sramkova, Martin Fried, Milan K Piya, Sudhesh Kumar, Gyanendra Tripathi, Philip G McTernan
BACKGROUND: The ileal-derived hormone, fibroblast growth factor 19 (FGF-19), may promote weight loss and facilitate type-2 diabetes mellitus remission in bariatric surgical patients. We investigated the effect of different bariatric procedures on circulating FGF-19 levels and the resulting impact on mitochondrial health in white adipose tissue (AT). METHODS: Obese and type-2 diabetic women (n = 39, BMI > 35 kg/m(2)) undergoing either biliopancreatic diversion (BPD), laparoscopic greater curvature plication (LGCP), or laparoscopic adjustable gastric banding (LAGB) participated in this ethics approved study...
February 16, 2017: BMC Medicine
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