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metabolic changes post bariatric surgery

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https://www.readbyqxmd.com/read/27900559/upregulated-tnf-expression-1%C3%A2-year-after-bariatric-surgery-reflects-a-cachexia-like-state-in-subcutaneous-adipose-tissue
#1
Alexander Jürets, Bianca Karla Itariu, Magdalena Keindl, Gerhard Prager, Felix Langer, Viktor Grablowitz, Maximilian Zeyda, Thomas Michael Stulnig
BACKGROUND: Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery. METHODS: Thirty-one severely obese patients (BMI ≥ 40 kg/m(2)) were examined before and after surgery...
November 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27818311/changes-in-bone-metabolism-after-bariatric-surgery-by-gastric-bypass-or-sleeve-gastrectomy
#2
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
Bariatric surgery results in rapid weight loss and beneficial metabolic effects, but may have negative effects on the skeleton. The objective of this prospective study was to evaluate changes in bone metabolism in response to bariatric surgery with two surgical techniques. 46 morbidly obese subjects (mean 44.9years, BMI 42.1) with (n=19) or without (n=27) type 2 diabetes (T2DM) at baseline underwent either Roux-en-Y gastric bypass (RYGB, n=21) or sleeve gastrectomy (SG, n=25). Bone turnover markers (CTX, PINP, TRAcP5b, TotalOC and ucOC) were measured before and six months after surgery...
November 3, 2016: Bone
https://www.readbyqxmd.com/read/27787482/fasting-and-post-prandial-peptide-yy-levels-in-obese-patients-before-and-after-two-types-of-the-bariatric-surgery-mini-gastric-bypass-and-roux-en-y-gastric-bypass
#3
Jolanta A Dardzińska, Łukasz Kaska, Piotr Wiśniewski, Ewa Aleksandrowicz-Wrona, Sylwia Małgorzewicz
BACKGROUND: Mechanisms underlying the metabolic effect of surgical treatment for morbid obesity are still not clear. Furthermore, the hormonal and metabolic response to the promising and moreover less invasive modification of Roux en Y Gastric Bypass (RYGB); Mini Gastric Bypass (MGB) is poorly known. The aim of this study was to evaluate pre- and post-prandial changes in PYY and metabolic parameters in obese patients without diabetes and cardiovascular complications treated by both versions of gastric bypass...
October 27, 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27738970/differential-changes-in-gut-microbiota-after-gastric-bypass-and-sleeve-gastrectomy-bariatric-surgery-vary-according-to-diabetes-remission
#4
Rinki Murphy, Peter Tsai, Mia Jüllig, Amy Liu, Lindsay Plank, Michael Booth
BACKGROUND: It is unclear whether specific gut microbiota is associated with remission of type 2 diabetes (T2D) after distinct types of bariatric surgery. AIMS: The aim of this study is to examine gut microbiota changes after laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery in obese patients with T2D. METHODS: Whole-metagenome shotgun sequencing of DNA fragments using Illumina HiSeq2000 was obtained from stool samples collected from 14 obese T2D patients pre-operatively (while on very low calorie diet) and 1 year after randomisation to laparoscopic SG (n = 7) or RYGB (n = 7)...
October 13, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27670865/a-mindfulness-based-intervention-to-control-weight-after-bariatric-surgery-preliminary-results-from-a-randomized-controlled-pilot-trial
#5
Sara A Chacko, Gloria Y Yeh, Roger B Davis, Christina C Wee
OBJECTIVE: This study aimed to develop and test a novel mindfulness-based intervention (MBI) designed to control weight after bariatric surgery. DESIGN: Randomized, controlled pilot trial. SETTING: Beth Israel Deaconess Medical Center, Boston, MA, USA. INTERVENTIONS: Bariatric patients 1-5 years post-surgery (n=18) were randomized to receive a 10-week MBI or a standard intervention. MAIN OUTCOME MEASURES: Primary outcomes were feasibility and acceptability of the MBI...
October 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27649688/increased-glucose-stimulated-fgf21-response-to-oral-glucose-in-obese-nondiabetic-subjects-after-roux-en-y-gastric-bypass
#6
S G Vienberg, S H Jacobsen, D Worm, L E Hvolris, L Naver, T Almdal, D L Hansen, B S Wulff, T R Clausen, S Madsbad, J J Holst, B Andersen
OBJECTIVE: The positive metabolic outcome of Roux-en-Y gastric bypass (RYGB) surgery may involve fibroblast growth factor 21 (FGF21), in both the fasting state and postprandially. We measured the fasting levels of FGF21 before and after bariatric surgery as well as the postprandial FGF21 responses after a glucose load and after a mixed meal. DESIGN: Observational intervention trial. PATIENTS AND MEASUREMENTS: Eight obese, nondiabetic patients underwent RYGB...
September 21, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27465735/peripheral-circadian-misalignment-contributor-to-systemic-insulin-resistance-and-potential-intervention-to-improve-bariatric-surgical-outcomes
#7
REVIEW
Kyle N Kunze, Erin C Hanlon, Vivek N Prachand, Matthew J Brady
Thirteen percent of the world's population suffers from obesity and 39% from being overweight, which correlates with an increase in numerous secondary metabolic complications, such as Type 2 diabetes mellitus. Bariatric surgery is the most effective treatment for severe obesity and results in significant weight loss and the amelioration of obesity-related comorbidities through changes in enteroendocrine activity, caloric intake, and alterations in gut microbiota composition. The circadian system has recently been found to be a critical regulatory component in the control of metabolism and, thus, may potentially play an important role in inappropriate weight gain...
September 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27398228/the-evolving-role-of-bariatric-surgery-in-patients-with-type-1-diabetes-and-obesity
#8
Ali A Rizvi
Bariatric surgery has emerged as a viable treatment option in morbidly obese individuals with type 2 diabetes. Concomitant with societal lifestyle changes and the increased emphasis on achieving metabolic targets, there has been a rise in the number of patients with type 1 diabetes (T1DM) who are overweight and obese. Preliminary experience based on a limited number of observational reports points to substantial weight loss and amelioration of comorbid conditions such as blood pressure and dyslipidemia in patients with T1DM who undergo weight loss surgery...
2016: Integrative Obesity and Diabetes
https://www.readbyqxmd.com/read/27327770/post-bariatric-surgery-changes-in-quinolinic-and-xanthurenic-acid-concentrations-are-associated-with-glucose-homeostasis
#9
Marie Favennec, Benjamin Hennart, Marie Verbanck, Marie Pigeyre, Robert Caiazzo, Violeta Raverdy, Hélène Verkindt, Audrey Leloire, Gilles J Guillemin, Loïc Yengo, Delphine Allorge, Philippe Froguel, François Pattou, Odile Poulain-Godefroy
BACKGROUND: An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue. Bariatric surgery decreases low-grade inflammation associated with obesity and improves glucose control. OBJECTIVE: Our goal was to determine the concentrations of all kynurenine metabolites after bariatric surgery and whether they were correlated with glucose control improvement...
2016: PloS One
https://www.readbyqxmd.com/read/27213116/a-large-animal-survival-model-to-evaluate-bariatric-surgery-mechanisms
#10
Vlad V Simianu, Jonathan G Sham, Andrew S Wright, Skye D Stewart, Mouhamad Alloosh, Michael Sturek, David E Cummings, David R Flum
BACKGROUND: The impact of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus is thought to result from upper and/or lower gut hormone alterations. Evidence supporting these mechanisms is incomplete, in part because of limitations in relevant bariatric-surgery animal models, specifically the lack of naturally insulin-resistant large animals. With overfeeding, Ossabaw swine develop a robust metabolic syndrome, and may be suitable for studying post-surgical physiology. Whether bariatric surgery is feasible in these animals with acceptable survival is unknown...
August 2015: Surgical Science
https://www.readbyqxmd.com/read/27120933/-not-available
#11
REVIEW
A-C Magain, T Richard, B De Becker, S Rorive, A Benahmed, M Vanhaeverbeek
In Belgium and around the world, the weight-control surgery has grown significantly since the beginning of the 21st century. The principal argument in favour of this type of surgery is the expected reduction of the obesity-associated morbidities. However, the expectatif reduction of mortality associated with this kind of surgery is based on a low level of evidence. Besides the mechanical complications, there are a number of health-related problems associated with the post-operative metabolic changes. Authors of the present article have observed four cases presenting with serious affections consecutive to bariatric interventions and reviewed the literature...
January 2016: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/26922185/stability-of-metabolic-factor-before-and-after-bariatric-surgery
#12
Brandon Davis, Joseph Indelicato
BACKGROUND: A new metric called metabolic factor (resting metabolic rate/weight) has previously been established that can differentiate between people who are obese, overweight, and of normal weight. Previous studies were re-analyzed and found that people who lost weight did not experience a change in their metabolic factor. MATERIALS AND METHODS: The current study measured the metabolic factor of 18 individuals before and after bariatric surgery. RESULTS: As expected, individuals lost nearly 100 lb and therefore lowered their resting metabolic rate from 2614...
October 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26902533/the-effect-of-laparoscopic-sleeve-gastrectomy-lsg-on-glycemic-control-in-morbidly-obese-patients
#13
Amit Gaur, C S Naidu, P P Rao, Sanjay Sharma, A K Singh, V Trehan, S V Kulkarni, Nishant Pathak, Amit Singh, Balram Goyal
INTRODUCTION: Bariatric procedures have become popular in treating not only the morbid obesity but also the metabolic derangements. Sleeve Gastrectomy has recently become popular as a standalone procedure and its usefulness as a metabolic procedure especially glycemic control is still under investigation. One of the most commonly used measure of insulin resistance is statistically derived 'Homeostatic model assessment of insulin resistance (HOMA-IR). AIM: The effect of Laparoscopic Sleeve Gastrectomy (LSG) on clinical and measurable change in glycemic control as seen by reduction of insulin resistance ie HOMA-IR levels in morbidly obese patients...
April 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/26886929/bariatric-surgery-in-obese-patients-with-type-1-diabetes-effects-on-weight-loss-and-metabolic-control
#14
Pauline Faucher, Christine Poitou, Claire Carette, Sophie Tezenas du Montcel, Charles Barsamian, Eliabelle Touati, Jean-Luc Bouillot, Adriana Torcivia, Sébastien Czernichow, Jean-Michel Oppert, Cécile Ciangura
BACKGROUND: Type 1 diabetes patients, although typically lean, experience an increased prevalence of obesity, and bariatric surgery is considered in severe cases. Bariatric surgery in such patients leads to significant weight loss and decreased insulin requirements; however, effects on glycemic control remain discussed. We assessed, in obese patients with type 1 diabetes, the effects of bariatric surgery upon body weight, body composition, and glycemic control, including the occurrence of hypoglycemic events...
October 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26865887/impact-of-post-laparoscopic-sleeve-gastrectomy-weight-loss-on-c-reactive-protein-lipid-profile-and-ca-125-in-morbidly-obese-women
#15
Ghada Morshed, Samah M Fathy
INTRODUCTION: Obesity increases production of adipose tissue-derived proteins, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Also there are elevated levels of C-reactive protein (CRP) and IL-6, CD8, and CD4, indicating chronic subclinical inflammation. Since obesity represents a serious risk factor in several metabolic diseases, identifying the status of carbohydrate antigen-125 (CA-125) would further link obesity and tumors. AIM: To examine the effect of weight loss by laparoscopic sleeve gastrectomy (LSG) on plasma CRP, lipid profiles and CA-125 level in morbidly obese patients...
January 2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/26827117/the-role-of-foregut-exclusion-in-the-deterioration-of-glucose-and-lipid-metabolism-induced-by-a-high-fat-diet
#16
Pengzhou Li, Liyong Zhu, Guohui Wang, Xiangwu Yang, Bo Yi, Shaihong Zhu
AIM: The small intestine may be involved in the improvement of glucose and lipid metabolism after bariatric surgery; however, the role of the foregut in metabolic changes remains unclear. This study used normal rats fed a high-fat diet (HFD) after bariatric surgery to determine the role of the foregut in glucose and lipid metabolism. METHODS: Duodenum-jejunum bypass (DJB), gastrojejunostomy (GJ) and sham-operations were performed on Sprague-Dawley (SD) rats. Oral glucose tolerance, insulin sensitivity, β-cell function, lipid profile, glucose-stimulated glucose-dependent insulinotropic polypeptide (GIP) levels and glucagon-like peptide-1 (GLP-1) levels were measured...
April 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/26663034/gastric-bypass-surgery-is-protective-from-high-fat-diet-induced-non-alcoholic-fatty-liver-disease-and-hepatic-endoplasmic-reticulum-stress
#17
J D Mosinski, M R Pagadala, A Mulya, H Huang, O Dan, H Shimizu, E Batayyah, R K Pai, P R Schauer, S A Brethauer, J P Kirwan
AIM: High-fat diets are known to contribute to the development of obesity and related co-morbidities including non-alcoholic fatty liver disease (NAFLD). The accumulation of hepatic lipid may increase endoplasmic reticulum (ER) stress and contribute to non-alcoholic steatohepatitis and metabolic disease. We hypothesized that bariatric surgery would counter the effects of a high-fat diet (HFD) on obesity-associated NAFLD. METHODS: Sixteen of 24 male Sprague Dawley rats were randomized to Sham (N = 8) or Roux-en-Y gastric bypass (RYGB) surgery (N = 8) and compared to Lean controls (N = 8)...
June 2016: Acta Physiologica
https://www.readbyqxmd.com/read/26583585/accumulation-and-changes-in-composition-of-collagens-in-subcutaneous-adipose-tissue-after-bariatric-surgery
#18
Yuejun Liu, Judith Aron-Wisnewsky, Geneviève Marcelin, Laurent Genser, Gilles Le Naour, Adriana Torcivia, Brigitte Bauvois, Sandrine Bouchet, Véronique Pelloux, Magali Sasso, Véronique Miette, Joan Tordjman, Karine Clément
CONTEXT: Extracellular matrix (ECM) in sc adipose tissue (scAT) undergoes pathological remodeling during obesity. However, its evolution during weight loss remains poorly explored. OBJECTIVE: The objective of the investigation was to study the histological, transcriptomic, and physical characteristics of scAT ECM remodeling during the first year of bariatric surgery (BS)-induced weight loss and their relationships with metabolic and bioclinical improvements. DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: A total of 118 morbidly obese candidates for BS were recruited and followed up during 1 year after BS...
January 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26468390/pancreatic-hyperplasia-after-gastric-bypass-surgery-in-a-gk-rat-model-of-non-obese-type-2-diabetes
#19
Xinrong Zhou, Bangguo Qian, Ning Ji, Conghui Lui, Zhiyuan Liu, Bing Li, Huarong Zhou, Caifeng Yan
Gastric bypass surgery produces clear antidiabetic effects in a substantial proportion of morbidly obese patients. In view of the recent trend away from 'bariatric' surgery and toward 'metabolic' surgery, it is important to elucidate the enhancing effect of bypass surgery on pancreatic β-cell mass, which is related to diabetes remission in non-obese patients. We investigated the effects of gastric bypass surgery on glycemic control and other pancreatic changes in a spontaneous non-obese type 2 diabetes Goto-Kakizaki rat model...
January 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/26420011/persistent-organic-pollutants-and-non-alcoholic-fatty-liver-disease-in-morbidly-obese-patients-a-cohort-study
#20
Panu Rantakokko, Ville Männistö, Riikka Airaksinen, Jani Koponen, Matti Viluksela, Hannu Kiviranta, Jussi Pihlajamäki
BACKGROUND: In animal experiments persistent organic pollutants (POPs) cause hepatosteatosis. In epidemiological studies POPs have positive associations with serum markers of nonalcoholic fatty liver disease (NAFLD) and together with obesity synergistic association with insulin resistance. Because insulin resistance and obesity are critical in NAFLD pathogenesis, we investigated the association of serum pollutant levels with liver histology and alanine aminotransferase (ALT) in morbidly obese...
2015: Environmental Health: a Global Access Science Source
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