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https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#1
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28486374/premature-thelarche-and-the-pura-syndrome
#2
Joshua Rezkalla, Tiffany Von Wald, Keith A Hansen
BACKGROUND: Premature thelarche is a self-limited condition characterized by Tanner stage II-III breast development in girls younger than 8 years of age with no evidence of advancing puberty. Evaluation concentrates on excluding central or peripheral causes of precocious puberty. CASE: A girl aged 2 years 4 months with profound hypotonia and delayed developmental milestones presented with Tanner II breast development, elevated follicle-stimulating hormone levels, suppressed luteinizing hormone level, normal growth and skeletal development, and prepubertal uterine length and ovarian volume...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28440677/no-association-between-estrogen-receptor-gene-polymorphisms-and-premature-thelarche-in-girls
#3
Hae Sang Lee, Jong Seo Yoon, Cheol Hwan So, Kyung Hee Kim, Jin Soon Hwang
OBJECTIVE: Premature thelarche (PT) is a benign, nonprogressive condition defined as isolated breast development. While the pathophysiology of PT remains unclear, increased sensitivity to estrogen may cause PT. The aim of this study was to investigate the association between polymorphisms in the estrogen receptor alpha (ERα) gene and PT in girls. METHODS: In this case-control study, we examined 96 girls referred for early breast development (before the age of 8 years)...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28422705/plasma-kisspeptin-and-ghrelin-levels-in-puberty-variant-cases
#4
Erdal Kurnaz, Yaşar Şen, Süleyman Aydın
BACKGROUND: The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders. METHODS: A PT group aged 1-8 years (n = 40), a PA group aged 1-9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study...
April 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28402984/contribution-of-hormonal-cytology-in-girls-and-adolescents-to-reproductive-health-a-traditional-technique-monitoring-recent-problems
#5
Jaroslava Dušková, Barbara Goldová, Lenka Matiášková, Alena Beková, Jana Skřenková
OBJECTIVE: To study the contribution of hormonal cytology in contemporary disturbances of fertility. DESIGN: Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patients were investigated, many of them several times and for a period longer than the 3 years analyzed. RESULTS: The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28400459/investigating-the-relationship-between-precocious-puberty-and-obesity-a-cross-sectional-study-in-shanghai-china
#6
Chang Chen, Yunting Zhang, Wanqi Sun, Yao Chen, Yanrui Jiang, Yuanjin Song, Qinmin Lin, Lixia Zhu, Qi Zhu, Xiumin Wang, Shijian Liu, Fan Jiang
OBJECTIVES: Obesity is reported to be closely relevant to early sexual development but the relationship between sexual precocity and obesity or central obesity is still inconsistent, especially in boys. We aimed to investigate the relationship between precocious puberty and obesity as well as central obesity. DESIGN: A large population-based cross-sectional study using multistage, stratified cluster random sampling. SETTING: Data from the Shanghai Children's Health, Education and Lifestyle Evaluation (SCHEDULE) study in June 2014...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28399535/17%C3%AE-estradiol-and-gonadotropin-levels-for-the-diagnosis-of-the-benign-form-of-breast-development-in-girls-aged-up-to-4-years-in-real-life-clinical-practice
#7
Martin Österbrand, Hans Fors, Kerstin Allvin, Ensio Norjavaara
BACKGROUND: Early onset of breast development in a young girl is usually a benign and isolated prepubertal condition, i.e., premature thelarche (PT), but can sometimes be progressive and the first sign of pubertal precocity (PP). Serum 17β-estradiol (17β-E2) level is a possible marker to differentiate between benign and pathological forms of breast development. We defined an upper serum 17β-E2 level for benign, "classic" PT for girls aged 9-48 months. METHODS: Serum 17β-E2 was analysed with a highly sensitive extraction radioimmunoassay (RIA)...
April 11, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28348072/the-follicle-stimulating-hormone-fsh-and-luteinizing-hormone-lh-response-to-a-gonadotropin-releasing-hormone-analogue-test-in-healthy-prepubertal-girls-aged-10-months-to-6-years
#8
Esben Thyssen Vestergaard, Mia Elbek Schjørring, Konstantinos Kamperis, Karin Kastberg Petersen, Søren Rittig, Anders Juul, Kurt Kritstensen, Niels Birkebæk
OBJECTIVE: Premature thelarche and precocious puberty are frequently diagnosed in girls even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH test is often included in the diagnostic work-up, although interpretation of the GnRH test in girls below 6 years of age is challenging, as no reference interval exists for this age group. The objective is to determine the normal FSH and LH response to a GnRH test in healthy prepubertal girls below 6 years of age...
March 27, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28245188/amh-levels-in-girls-with-various-pubertal-problems
#9
Senay Savas-Erdeve, Elif Sagsak, Meliksah Keskin, Semra Cetinkaya, Zehra Aycan
BACKGROUND: Anti-Müllerian hormone (AMH) is produced by granulosa cells surrounding follicles that have undergone recruitment from the primordial follicle pool but have not been selected for dominance (preantral and early antral follicles). In healthy girls, serum levels of AMH vary considerably between individuals. We aimed to evaluate the AMH level in girls with premature thelarche (PT) and central precocious puberty (CPP). METHODS: Girls with CPP (n=21), PT (n=24) and a control prepubertal group (n=22) were included in the study...
March 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28173872/childhood-body-size-and-pubertal-timing-in-relation-to-adult-mammographic-density-phenotype
#10
Minouk J Schoemaker, Michael E Jones, Steven Allen, Jean Hoare, Alan Ashworth, Mitch Dowsett, Anthony J Swerdlow
BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors of onset of puberty, such as weight and height, are mediated via mammographic density, an important risk factor for breast cancer. METHODS: We investigated whether childhood body size and pubertal timing and tempo, collected by questionnaire, are associated with percentage and absolute area mammographic density at ages 47-73 years in 1105 women recruited to a prospective study...
February 7, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28161677/serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-as-potential-markers-for-progressive-central-precocious-puberty-in-girls
#11
Ting Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Linqi Chen
STUDY OBJECTIVE: To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A total of 148 girls were enrolled, including 65 girls with premature thelarche and 83 girls with CPP, grouped on the basis of the results of gonadotropin-releasing hormone stimulation tests. Girls with CPP underwent a 6-month follow-up, and were further divided into 2 subgroups: the progressive CPP (P-CPP) group (n = 55) and the slowly P-CPP (SP-CPP) group (n = 28)...
February 1, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28112874/duration-of-puberty-in-preterm-girls
#12
L L Hui, H S Lam, G M Leung, C M Schooling
OBJECTIVES: Preterm birth is associated with altered pubertal timing, but the effect on pubertal duration has rarely been assessed. Here, we tested the hypothesis that preterm birth is associated with shorter duration of puberty among girls in Hong Kong where preterm birth has little social patterning. METHODS: In the population-representative Chinese birth cohort "Children of 1997", we used multivariable linear regression to assess the association of preterm status (≤36 completed gestational weeks, n = 170; term birth 37-42 gestational weeks, n = 3476) with duration of puberty, adjusted for parent's highest education, mother's place of birth, maternal smoking during pregnancy, gestational diabetes, preeclampsia, and mother's age of menarche...
January 23, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28009526/pubertal-progression-and-reproductive-hormones-in-healthy-girls-with-transient-thelarche
#13
Marie Lindhardt Johansen, Casper P Hagen, Mikkel G Mieritz, Ole D Wolthers, Carsten Heuck, Jørgen Holm Petersen, Anders Juul
Context: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse, and the phenomenon of transient thelarche (TT), defined as the appearance, regression, and subsequent reappearance of breast buds, in healthy girls remains undescribed. Objective: To describe TT in terms of pubertal progression, growth, genotypes, and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair, and menarche. Design: A prospective, longitudinal population-based study...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28008860/basal-serum-neurokinin-b-levels-in-differentiating-idiopathic-central-precocious-puberty-from-premature-thelarche
#14
Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz
OBJECTIVE: To find out the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: The girls who presented with early breast development before the age of 8 years were evaluated. Patients with intracranial pathologies were excluded. Basal and stimulated follicle-stimulating hormone/luteinizing hormone (LH) levels and basal neurokinin B/kisspeptin levels were measured. Patients who had peak value of LH >5 mIU/mL and a bone age (BA)/chronological age (CA) ratio >1...
June 1, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27424312/time-course-of-central-precocious-puberty-development-caused-by-an-mkrn3-gene-mutation-a-prismatic-case
#15
Monica F Stecchini, Delanie B Macedo, Ana Claudia S Reis, Ana Paula Abreu, Ayrton C Moreira, Margaret Castro, Ursula B Kaiser, Ana Claudia Latronico, Sonir R Antonini
BACKGROUND: Loss-of-function mutations in the imprinted gene MKRN3 represent the most common known genetic defects associated with central precocious puberty (CPP). METHODS: We report the first case of a girl carrying an MKRN3 mutation detected in childhood and followed until the development of pubertal signs. RESULTS: The girl was screened at the age of 4 years because of a positive family history; her sister had developed CPP at 6 years of age and was found to harbor the MKRN3 p...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27254044/age-of-onset-of-puberty-in-apparently-healthy-school-girls-from-northern-india
#16
Rajesh Khadgawat, R K Marwaha, Neena Mehan, Vineet Surana, Aashima Dabas, V Sreenivas, M Ashraf Gaine, Nandita Gupta
OBJECTIVE: To determine the age of pubertal onset and menarche in school-going girls, and to assess the impact of obesity on pubertal timing. DESIGN: Cross-sectional. SETTING: Seven schools across Delhi, India. PARTICIPANTS: 2010 school girls, aged 6-17 years. METHODS: Anthropometric measurement and pubertal staging was performed for all subjects. Menarche was recorded by status quo method. Body mass index was used to define overweight/obesity...
May 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27191050/central-precocious-puberty-revisiting-the-diagnosis-and-therapeutic-management
#17
REVIEW
Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty...
April 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27035145/serum-levels-of-polybrominated-diphenyl-ethers-in-girls-with-premature-thelarche
#18
Annalisa Deodati, Alessia Sallemi, Francesca Maranghi, Daniela Germani, Antonella Puglianiello, Francesca Baldari, Luca Busani, Francesca Romana Mancini, Roberta Tassinari, Alberto Mantovani, Stefano Cianfarani
BACKGROUND/AIMS: Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between the exposure to PBDEs and alterations of puberty in girls referred for idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: A case-control study was conducted in 124 girls: 37 girls with ICPP (mean age 7.4 ± 0...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26909102/increasing-incidence-of-premature-thelarche-in-the-central-region-of-denmark-challenges-in-differentiating-girls-less-than-7%C3%A2-years-of-age-with-premature-thelarche-from-girls-with-precocious-puberty-in-real-life-practice
#19
Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen, Niels Holtum Birkebæk
BACKGROUND: Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two diagnoses. METHODS: One hundred ninety-one girls aged 0.5-7 years were included. Diagnoses were validated and the girls were categorized to the groups PP (n = 27) and PT (n = 164). Anthropometry, Tanner stages, ethnicity, bone age, and biochemistry, were recorded...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/26866003/the-diagnostic-value-of-pelvic-ultrasound-in-girls-with-central-precocious-puberty
#20
Sang Heon Lee, Eun Young Joo, Ji-Eun Lee, Yong-Hoon Jun, Mi-Young Kim
The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for differentiating central precocious puberty (CPP) from exaggerated thelarche (ET). Because of this test's limitations, previous studies have clarified the clinical and laboratory factors that predict CPP. The present study investigated the early diagnostic significance of pelvic ultrasound in girls with CPP. The GnRH stimulation test and pelvic ultrasound were performed between March 2007 and February 2015 in 192 girls (aged <8 years) with signs of early puberty and advanced bone age...
January 2016: Chonnam Medical Journal
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