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https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#1
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29215515/isolated-absent-thelarche-in-a-patient-with-neurofibromatosis-type-1-and-acromegaly
#2
Anne E Martini, Jessica R Zolton, Alan H DeCherney
BACKGROUND: Isolated absent thelarche is a rare condition that is infrequently reviewed in the literature. CASE: A 28-year-old woman with neurofibromatosis type 1 and acromegaly presented with absent breast development despite hormone therapy. Examination noted a normally developed woman with acromegalic features and Tanner stage I breasts. Hormone studies and karyotype were normal. Magnetic resonance imaging of the patient's brain demonstrated a voluminous pituitary...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29174167/progress-in-the-diagnosis-and-management-of-adolescent-endometriosis-an-opinion
#3
REVIEW
Giuseppe Benagiano, Sun-Wei Guo, Patrick Puttemans, Stephan Gordts, Ivo Brosens
Increasing evidence indicates that early onset endometriosis (EOE), starting around menarche or early adolescence, may have an origin different from the adult variant, originating from neonatal uterine bleeding (NUB). This implies seeding of naïve endometrial progenitor cells into the pelvic cavity with NUB; these can then activate around thelarche. It has its own pathophysiology, symptomatology and risk factors, warranting critical management re-evaluation. It can also be progressive, endangering future reproductive capacity...
October 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29163361/girls-with-a-history-of-premature-adrenarche-have-advanced-growth-and-pubertal-development-at-the-age-of-12-years
#4
Jani Liimatta, Pauliina Utriainen, Raimo Voutilainen, Jarmo Jääskeläinen
Background: Premature adrenarche (PA) has been linked to early thelarche and menarche, but longitudinal data on growth and pubertal development after PA are insufficient. Methods: Growth and pubertal development of mostly full-term and appropriate for gestational age-born 43 PA (36 girls) and 63 control children (52 girls) were analyzed prospectively. Children examined first at the mean age of 7.6 years were reexamined at the mean age of 12.0 years. Results: The PA girls but not the boys were taller and had higher body mass index (BMI) than the controls...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#5
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29077908/differential-impact-of-genetic-loci-on-age-at-thelarche-and-menarche-in-healthy-girls
#6
Alexander S Busch, Casper P Hagen, Maria Assens, Katharina M Main, Kristian Almstrup, Anders Juul
Context: Recent genetic studies have identified genetic variants associated with age at pubertal onset. While Genome wide association studies reported associations of several hundred genetic variants with timing of self-reported age at menarche, a recent clinical study focussed on genetic variation affecting FSH action and clinically determined age at thelarche. The observations appear to be incongruent as effect sizes varied substantially between the studies. Alternatively, this may point to a differential impact of specific genetic loci on distinct pubertal events...
October 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29020129/maternal-pre-pregnancy-bmi-gestational-weight-gain-and-daughter-s-age-at-menarche-the-avon-longitudinal-study-of-parents-and-children
#7
Rebecca B Lawn, Debbie A Lawlor, Abigail Fraser
Earlier puberty and menarcheal age are associated with adverse health outcomes. Reported associations of maternal adiposity with daughters' menarcheal age are inconsistent. We examined associations between maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG), and daughters' age at menarche (n = 3,935), pubarche (Tanner stage 2 for pubic hair) and thelarche (Tanner stage 2 for breast development) (n = 2,942) in the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort (baseline 1991-1992)...
September 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29018155/clinical-characteristics-of-138-chinese-female-patients-with-idiopathic-hypogonadotropic-hypogonadism
#8
Rui-Yi Tang, Rong Chen, Miao Ma, Shou-Qing Lin, Yi-Wen Zhang, Ya-Ping Wang
OBJECTIVE: To evaluate the clinical features of Chinese women with idiopathic hypogonadotropic hypogonadism (IHH). METHODS: We retrospectively reviewed the clinical characteristics, laboratory and imaging findings, therapeutic management and fertility outcomes of 138 women with IHH. All patients had been treated and followed up at an academic medical centre during 1990-2016. RESULTS: Among the 138 patients, 82 patients (59.4%) were diagnosed with normosmic IHH and 56 patients (40...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28939588/childhood-socioeconomic-position-and-pubertal-onset-in-a-cohort-of-multiethnic-girls-implications-for-breast-cancer
#9
Robert A Hiatt, Susan L Stewart, Kristin S Hoeft, Lawrence H Kushi, Gayle C Windham, Frank M Biro, Susan M Pinney, Mary S Wolff, Susan L Teitelbaum, Dejana Braithwaite
BACKGROUND: Higher socioeconomic position (SEP) has been associated with increased risk of breast cancer. Its relationship with earlier age of pubertal onset, a risk factor for breast cancer, is less clear. METHODS: We studied the relationship of SEP to pubertal onset in multiethnic cohort of 1237 girls aged 6-8 years at baseline. Girls in three U.S. cities were followed for 5-8 years with annual clinical examinations from 2004 to 2012. SEP measures were examined for associations with pubertal onset, assessed by breast budding (thelarche) and pubic hair development (adrenarche)...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28878739/precocious-puberty-or-premature-thelarche-analysis-of-a-large-patient-series-in-a-single-tertiary-center-with-special-emphasis-on-6-to-8-year-old-girls
#10
Tero Varimo, Heta Huttunen, Päivi Johanna Miettinen, Laura Kariola, Johanna Hietamäki, Annika Tarkkanen, Matti Hero, Taneli Raivio
INTRODUCTION: We describe the etiology, MRI findings, and growth patterns in girls who had presented with signs of precocious puberty (PP), i.e., premature breast development or early menarche. Special attention was paid to the diagnostic findings in 6- to 8-year-olds. MATERIALS AND METHODS: We reviewed the medical records of 149 girls (aged 0.7-10.3 years) who had been evaluated for PP in the Helsinki University Hospital between 2001 and 2014. RESULTS: In 6- to 8-year-old girls, PP was most frequently caused by idiopathic gonadotropin-releasing hormone (GnRH)-dependent PP (60%) and premature thelarche (PT; 39%)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28804211/apparent-cyclic-vaginal-bleeding-in-a-child-factitious-disorder
#11
Ahmet Ucakturk, Figen Gunindi, Murat Aydin
A 20-mo-old girl was brought to our department by her mother because of breast enlargement. She was diagnosed with premature thelarche. One month later, she returned to our hospital with a complaint of vaginal bleeding. During the subsequent 6 mo, her vaginal bleeding recurred every month while her breast development disappeared. We performed laboratory tests and imaging. At the end of 6 mo, we realized that her mother's menstrual bleeding and the patient's blood staining were concurrent. The mother confessed applying her vaginal flow to her daughter's underwear...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28697822/-diagnostic-value-of-baseline-serum-luteinizing-hormone-level-for-central-precocious-puberty-in-girls
#12
Li-Xue Ou-Yang, Fan Yang
OBJECTIVE: To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls. METHODS: A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT)...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#13
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28486374/premature-thelarche-and-the-pura-syndrome
#14
Joshua Rezkalla, Tiffany Von Wald, Keith A Hansen
BACKGROUND: Premature thelarche is a self-limited condition characterized by Tanner stage II-III breast development in girls younger than 8 years of age with no evidence of advancing puberty. Evaluation concentrates on excluding central or peripheral causes of precocious puberty. CASE: A girl aged 2 years 4 months with profound hypotonia and delayed developmental milestones presented with Tanner II breast development, elevated follicle-stimulating hormone levels, suppressed luteinizing hormone level, normal growth and skeletal development, and prepubertal uterine length and ovarian volume...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28440677/no-association-between-estrogen-receptor-gene-polymorphisms-and-premature-thelarche-in-girls
#15
Hae Sang Lee, Jong Seo Yoon, Cheol Hwan So, Kyung Hee Kim, Jin Soon Hwang
OBJECTIVE: Premature thelarche (PT) is a benign, nonprogressive condition defined as isolated breast development. While the pathophysiology of PT remains unclear, increased sensitivity to estrogen may cause PT. The aim of this study was to investigate the association between polymorphisms in the estrogen receptor alpha (ERα) gene and PT in girls. METHODS: In this case-control study, we examined 96 girls referred for early breast development (before the age of 8 years)...
October 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28422705/plasma-kisspeptin-and-ghrelin-levels-in-puberty-variant-cases
#16
Erdal Kurnaz, Yaşar Şen, Süleyman Aydın
BACKGROUND: The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders. METHODS: A PT group aged 1-8 years (n = 40), a PA group aged 1-9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study...
April 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28402984/contribution-of-hormonal-cytology-in-girls-and-adolescents-to-reproductive-health-a-traditional-technique-monitoring-recent-problems
#17
Jaroslava Dušková, Barbara Goldová, Lenka Matiášková, Alena Beková, Jana Skřenková
OBJECTIVE: To study the contribution of hormonal cytology in contemporary disturbances of fertility. DESIGN: Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patients were investigated, many of them several times and for a period longer than the 3 years analyzed. RESULTS: The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28400459/investigating-the-relationship-between-precocious-puberty-and-obesity-a-cross-sectional-study-in-shanghai-china
#18
Chang Chen, Yunting Zhang, Wanqi Sun, Yao Chen, Yanrui Jiang, Yuanjin Song, Qinmin Lin, Lixia Zhu, Qi Zhu, Xiumin Wang, Shijian Liu, Fan Jiang
OBJECTIVES: Obesity is reported to be closely relevant to early sexual development but the relationship between sexual precocity and obesity or central obesity is still inconsistent, especially in boys. We aimed to investigate the relationship between precocious puberty and obesity as well as central obesity. DESIGN: A large population-based cross-sectional study using multistage, stratified cluster random sampling. SETTING: Data from the Shanghai Children's Health, Education and Lifestyle Evaluation (SCHEDULE) study in June 2014...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28399535/17%C3%AE-estradiol-and-gonadotropin-levels-for-the-diagnosis-of-the-benign-form-of-breast-development-in-girls-aged-up-to-4-years-in-real-life-clinical-practice
#19
Martin Österbrand, Hans Fors, Kerstin Allvin, Ensio Norjavaara
BACKGROUND: Early onset of breast development in a young girl is usually a benign and isolated prepubertal condition, i.e., premature thelarche (PT), but can sometimes be progressive and the first sign of pubertal precocity (PP). Serum 17β-estradiol (17β-E2) level is a possible marker to differentiate between benign and pathological forms of breast development. We defined an upper serum 17β-E2 level for benign, "classic" PT for girls aged 9-48 months. METHODS: Serum 17β-E2 was analysed with a highly sensitive extraction radioimmunoassay (RIA)...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28348072/the-follicle-stimulating-hormone-fsh-and-luteinizing-hormone-lh-response-to-a-gonadotropin-releasing-hormone-analogue-test-in-healthy-prepubertal-girls-aged-10-months-to-6-years
#20
Esben T Vestergaard, Mia E Schjørring, Konstantinos Kamperis, Karin Kastberg Petersen, Søren Rittig, Anders Juul, Kurt Kristensen, Niels H Birkebæk
OBJECTIVE: Premature thelarche and precocious puberty are frequently diagnosed in girls even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH test is often included in the diagnostic work-up, although interpretation of the GnRH test in girls below 6 years of age is challenging, as no reference interval exists for this age group. The objective is to determine the normal FSH and LH response to a GnRH test in healthy prepubertal girls below 6 years of age...
June 2017: European Journal of Endocrinology
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