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https://www.readbyqxmd.com/read/27424312/time-course-of-central-precocious-puberty-development-caused-by-an-mkrn3-gene-mutation-a-prismatic-case
#1
Monica F Stecchini, Delanie B Macedo, Ana Claudia S Reis, Ana Paula Abreu, Ayrton C Moreira, Margaret Castro, Ursula B Kaiser, Ana Claudia Latronico, Sonir R Antonini
BACKGROUND: Loss-of-function mutations in the imprinted gene MKRN3 represent the most common known genetic defects associated with central precocious puberty (CPP). METHODS: We report the first case of a girl carrying an MKRN3 mutation detected in childhood and followed until the development of pubertal signs. RESULTS: The girl was screened at the age of 4 years because of a positive family history; her sister had developed CPP at 6 years of age and was found to harbor the MKRN3 p...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27254044/age-of-onset-of-puberty-in-apparently-healthy-school-girls-from-northern-india
#2
Rajesh Khadgawat, R K Marwaha, Neena Mehan, Vineet Surana, Aashima Dabas, V Sreenivas, M Ashraf Gaine, Nandita Gupta
OBJECTIVE: To determine the age of pubertal onset and menarche in school-going girls, and to assess the impact of obesity on pubertal timing. DESIGN: Cross-sectional. SETTING: Seven schools across Delhi, India. PARTICIPANTS: 2010 school girls, aged 6-17 years. METHODS: Anthropometric measurement and pubertal staging was performed for all subjects. Menarche was recorded by status quo method. Body mass index was used to define overweight/obesity...
May 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27191050/central-precocious-puberty-revisiting-the-diagnosis-and-therapeutic-management
#3
Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty...
April 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27035145/serum-levels-of-polybrominated-diphenyl-ethers-in-girls-with-premature-thelarche
#4
Annalisa Deodati, Alessia Sallemi, Francesca Maranghi, Daniela Germani, Antonella Puglianiello, Francesca Baldari, Luca Busani, Francesca Romana Mancini, Roberta Tassinari, Alberto Mantovani, Stefano Cianfarani
BACKGROUND/AIMS: Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between the exposure to PBDEs and alterations of puberty in girls referred for idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: A case-control study was conducted in 124 girls: 37 girls with ICPP (mean age 7.4 ± 0...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26909102/increasing-incidence-of-premature-thelarche-in-the-central-region-of-denmark-challenges-in-differentiating-girls-less-than-7%C3%A2-years-of-age-with-premature-thelarche-from-girls-with-precocious-puberty-in-real-life-practice
#5
Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen, Niels Holtum Birkebæk
BACKGROUND: Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two diagnoses. METHODS: One hundred ninety-one girls aged 0.5-7 years were included. Diagnoses were validated and the girls were categorized to the groups PP (n = 27) and PT (n = 164). Anthropometry, Tanner stages, ethnicity, bone age, and biochemistry, were recorded...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/26866003/the-diagnostic-value-of-pelvic-ultrasound-in-girls-with-central-precocious-puberty
#6
Sang Heon Lee, Eun Young Joo, Ji-Eun Lee, Yong-Hoon Jun, Mi-Young Kim
The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for differentiating central precocious puberty (CPP) from exaggerated thelarche (ET). Because of this test's limitations, previous studies have clarified the clinical and laboratory factors that predict CPP. The present study investigated the early diagnostic significance of pelvic ultrasound in girls with CPP. The GnRH stimulation test and pelvic ultrasound were performed between March 2007 and February 2015 in 192 girls (aged <8 years) with signs of early puberty and advanced bone age...
January 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/26849015/thyroid-hormones-and-timing-of-pubertal-onset-in-a-longitudinal-cohort-of-females-northern-california-2006-11
#7
Jason A Wilken, Louise C Greenspan, Lawrence H Kushi, Robert W Voss, Gayle C Windham
BACKGROUND: Pubertal timing is regulated by a complex interplay of hormones. Few studies have evaluated the role of thyroid hormones in pubertal onset. We investigated the associations between blood concentrations of free and total thyroxine (FT4, TT4), free triiodothyronine, and thyroid stimulating hormone and pubertal onset among females. METHODS: Participants included 323 Kaiser Permanente Northern California members followed at annual intervals during 2004-11, who provided a blood sample during the first 3 years of the study...
May 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/26831552/plasma-kisspeptin-levels-in-newborn-infants-with-breast-enlargement
#8
Avni Kaya, Zerrin Orbak, Harun Polat, Atilla Çayır, Abdullah Erdil, Hakan Döneray
OBJECTIVE: Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement. METHODS: Plasma kisspeptin levels and other related biochemical variables were investigated in this prospective study conducted on 40 (20 girls and 20 boys) newborn infants with breast enlargement and on 40 healthy control infants (20 girls and 20 boys)...
September 2015: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/26388894/usefulness-of-pelvic-ultrasonography-for-the-diagnosis-of-central-precocious-puberty-in-girls
#9
Jung Yu, Ha Young Shin, Sun Hee Lee, You Sung Kim, Jae Hyun Kim
PURPOSE: It is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development. METHODS: This study included girls with early breast development who visited the clinic between January 2012 and December 2013. Clinical, laboratory, and pelvic ultrasonographic data were evaluated...
August 2015: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/26369578/ultrasensitive-estrogen-levels-at-7-years-of-age-predict-earlier-thelarche-evidence-from-girls-of-the-growth-and-obesity-chilean-cohort
#10
Ana Pereira, Camila Corvalán, Ricardo Uauy, Karen O Klein, Verónica Mericq
OBJECTIVE: Prepubertal estradiol equivalents have been inconsistently linked to age at thelarche; elucidating this relationship becomes relevant given the worldwide decline in the age of puberty onset. Thus, our aim is to assess whether prepubertal girls with higher serum levels of estradiol equivalents at age 7 have a greater risk of presenting early thelarche (ET). DESIGN: Nested case-control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (∼50% girls) from Santiago, Chile...
December 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26353172/prepubertal-gynecomastia-and-chronic-lavender-exposure-report-of-three-cases
#11
Alejandro Diaz, Laura Luque, Zain Badar, Steve Kornic, Marco Danon
INTRODUCTION: Prepubertal gynecomastia is a rare condition characterized by the growth of breast tissue in males as a consequence of early exposure to sexual hormones. When this condition is present, pathological sources of testosterone/estrogen production, such as adrenal or gonadal tumors must be searched for. A few reports have described an association between gynecomastia and substances that produce stimulation of the estrogen receptor, such as lavender and tea tree oil. METHODS: Here we describe the cases of three boys who presented with prepubertal gynecomastia and were chronically exposed to lavender...
January 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/26286459/growth-and-hormone-profiling-in-children-with-congenital-melanocytic-naevi
#12
R Waelchli, J Williams, T Cole, M Dattani, P Hindmarsh, H Kennedy, A Martinez, S Khan, R K Semple, A White, N Sebire, E Healy, G Moore, V A Kinsler
BACKGROUND: Multiple congenital melanocytic naevi (CMN) is a rare mosaic RASopathy, caused by postzygotic activating mutations in NRAS. Growth and hormonal disturbances are described in germline RASopathies, but growth and hormone status have not previously been investigated in individuals with CMN. OBJECTIVES: To explore premature thelarche, undescended testes, and a clinically abnormal fat distribution with CMN through prospective endocrinological assessment of a cohort of subjects with CMN, and a retrospective review of longitudinal growth of a larger group of patients with CMN from outpatient clinics (which included all subjects in the endocrinological assessment group)...
December 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/26226120/amh-levels-at-central-precocious-puberty-and-premature-thelarche-is-it-a-parameter
#13
Nursel Muratoglu Sahin, Sibel Tulgar Kinik, Mustafa Agah Tekindal, Nilufer Bayraktar
BACKGROUND: The possible difference of antimüllerian hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated. OBJECTIVE/HYPOTHESIS: By evaluating AMH levels in girls with diagnosed CPP and PT, we aim to show the change of AMH levels at the pubertal onset. SUBJECTS: Sixty-five girls who have breast development before the age of 8 years and 25 healthy girls were enrolled in the study...
November 1, 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/26151490/predicting-pubertal-development-by-infantile-and-childhood-height-bmi-and-adiposity-rebound
#14
MULTICENTER STUDY
Alina German, Michael Shmoish, Ze'ev Hochberg
BACKGROUND: Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES: (i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS: We utilized published prospective data from 659 girls and 706 boys of the Study of Early Child Care and Youth Development. We investigated the age of pubarche-thelarche-gonadarche-menarche as a function of early height, BMI, and AR...
October 2015: Pediatric Research
https://www.readbyqxmd.com/read/26136989/testing-of-kisspeptin-levels-in-girls-with-idiopathic-central-precocious-puberty-and-its-significance
#15
Y U Yang, Xiang-Yu Xiong, L I Yang, Liling Xie, Hui Huang
The aim of this study was to explore the significance of plasma kisspeptin levels in diagnosis and therapeutic evaluation through the analysis of the kisspeptin levels of girls diagnosed with idiopathic central precocious puberty (ICPP) prior to treatment and after 6-months of treatment and those with simple premature thelarche (PT). A total of 70 girls including 24 girls diagnosed with ICPP, 21 girls with PT and 25 normal girls were enrolled in the study. ELISA analysis was conducted to detect the plasma levels of kisspeptin...
June 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26132407/a-dilemma-premature-thelarche-or-normal-pubertal-development
#16
Erkan Sari, Mustafa Gulgun, Adem Polat, Ediz Yesilkaya
No abstract text is available yet for this article.
September 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26094907/gonadotropin-and-estradiol-levels-after-leuprolide-stimulation-tests-in-brazilian-girls-with-precocious-puberty
#17
Flavia R R Junqueira, Lucia A S Lara, Wellington P Martins, Rui A Ferriani, Ana Carolina J S Rosa-E-Silva, Marcos Felipe S de Sá, Rosana M Reis
STUDY OBJECTIVE: To determine the best cutoff value on the leuprolide stimulation test for the diagnosis of central precocious puberty (CPP) in a Brazilian population. DESIGN, SETTING, AND PARTICIPANTS: This observational study included 60 girls with CPP, as shown on the basis of serum concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) before and 3 hours after subcutaneous administration of 500 μg leuprolide acetate and by measuring serum estradiol concentrations 24 hours later...
October 2015: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26078693/clinical-and-laboratory-findings-in-the-differential-diagnosis-of-central-precocious-puberty-and-premature-thelarche
#18
Gönül Çatlı, Pınar Erdem, Ahmet Anık, Ayhan Abacı, Ece Böber
AIM: In this study, it was aimed to evaluate the clinical, antropometric and laboratory findings of female patients diagnosed with central precocious puberty and to determine the laboratory value with the best diagnostic accuracy in the diagnosis of central precocious puberty. MATERIALS AND METHOD: Female patients whose breast development began before the age of 8 years were included in the study. The data of the patients were obtained by retrospectively examining file records...
March 2015: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/26030789/clinical-characteristics-of-children-referred-for-signs-of-early-puberty-before-age-3
#19
Paul B Kaplowitz, Rinku Mehra
BACKGROUND: Signs of puberty in very young children are often benign, but the evaluation needed and follow-up are controversial. OBJECTIVES: The study had three objectives: 1) to analyze the frequency of diagnoses in children <3 years referred for early puberty; 2) to examine the usefulness of lab testing; and 3) to identify red flags indicating a more serious diagnosis. METHODS: Charts of all children younger than age 3 referred for early puberty between 7/09 and 6/13 were reviewed...
September 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/25993671/puberty-in-a-sample-of-brazilian-schoolgirls-timing-and-anthropometric-characteristics
#20
Taciana Carla Maia Feibelmann, Adriana Paula da Silva, Daniela Cristina Silva Resende, Elisabete Aparecida Mantovani Rodrigues de Resende, Lúcia Marina Scatena, Maria de Fátima Borges
OBJECTIVE: The objective of this study was to determine the age at which puberty begins, age of menarche and anthropometric data of the participants at different stages of puberty. SUBJECTS AND METHODS: This is a cross-sectional study in which we evaluated 665 girls, a sample representing the female schoolchildren population in Uberaba. RESULTS: We found that thelarche, pubarche, underarm hair and menarche were attained at the age of 9.8 ± 1...
April 2015: Archives of Endocrinology and Metabolism
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