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Senay Savas-Erdeve, Elif Sagsak, Meliksah Keskin, Semra Cetinkaya, Zehra Aycan
BACKGROUND: Anti-Müllerian hormone (AMH) is produced by granulosa cells surrounding follicles that have undergone recruitment from the primordial follicle pool but have not been selected for dominance (preantral and early antral follicles). In healthy girls, serum levels of AMH vary considerably between individuals. We aimed to evaluate the AMH level in girls with premature thelarche (PT) and central precocious puberty (CPP). METHODS: Girls with CPP (n=21), PT (n=24) and a control prepubertal group (n=22) were included in the study...
March 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
Minouk J Schoemaker, Michael E Jones, Steven Allen, Jean Hoare, Alan Ashworth, Mitch Dowsett, Anthony J Swerdlow
BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors of onset of puberty, such as weight and height, are mediated via mammographic density, an important risk factor for breast cancer. METHODS: We investigated whether childhood body size and pubertal timing and tempo, collected by questionnaire, are associated with percentage and absolute area mammographic density at ages 47-73 years in 1105 women recruited to a prospective study...
February 7, 2017: Breast Cancer Research: BCR
Ting Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Linqi Chen
STUDY OBJECTIVE: To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). DESIGN, SETTING, AND PARTICIPANTS, INTERWENTIONS, AND MAIN OUTCOME MEASURES: A total of 148 girls were enrolled, including 65 girls with premature thelarche (PT) and 83 girls with CPP, grouped based on the results of Gonadotropin-releasing hormone (GnRH) stimulation tests. Girls with CPP underwent a six-month follow-up, and were further divided into two subgroups: progressive CPP (P-CPP) group (n=55) and slowly progressive CPP (SP-CPP) group (n=28)...
February 1, 2017: Journal of Pediatric and Adolescent Gynecology
L L Hui, H S Lam, G M Leung, C M Schooling
OBJECTIVES: Preterm birth is associated with altered pubertal timing, but the effect on pubertal duration has rarely been assessed. Here, we tested the hypothesis that preterm birth is associated with shorter duration of puberty among girls in Hong Kong where preterm birth has little social patterning. METHODS: In the population-representative Chinese birth cohort "Children of 1997", we used multivariable linear regression to assess the association of preterm status (≤36 completed gestational weeks, n = 170; term birth 37-42 gestational weeks, n = 3476) with duration of puberty, adjusted for parent's highest education, mother's place of birth, maternal smoking during pregnancy, gestational diabetes, preeclampsia, and mother's age of menarche...
January 23, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
Marie Lindhardt Johansen, Casper P Hagen, Mikkel G Mieritz, Ole D Wolthers, Carsten Heuck, Jørgen Holm Petersen, Anders Juul
CONTEXT: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse and the phenomenon of transient thelarche (TT), defined as the appearance, regression and subsequent reappearance of breast buds, in healthy girls remains undescribed. OBJECTIVE: To describe TT in terms of pubertal progression, growth, genotypes and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair and menarche. DESIGN: A prospective, longitudinal population-based study...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz
OBJECTIVE: The aim of the study is to investigate the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: The girls who presented with early breast development before the age of 8 years were evaluated. Basal and stimulated FSH, LH levels and basal neurokinin B and kisspeptin levels were measured. Patients who had peak LH > 5mIU/mL, and a bone age (BA) /chronological age (CA) ratio >1...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
Monica F Stecchini, Delanie B Macedo, Ana Claudia S Reis, Ana Paula Abreu, Ayrton C Moreira, Margaret Castro, Ursula B Kaiser, Ana Claudia Latronico, Sonir R Antonini
BACKGROUND: Loss-of-function mutations in the imprinted gene MKRN3 represent the most common known genetic defects associated with central precocious puberty (CPP). METHODS: We report the first case of a girl carrying an MKRN3 mutation detected in childhood and followed until the development of pubertal signs. RESULTS: The girl was screened at the age of 4 years because of a positive family history; her sister had developed CPP at 6 years of age and was found to harbor the MKRN3 p...
2016: Hormone Research in Pædiatrics
Rajesh Khadgawat, R K Marwaha, Neena Mehan, Vineet Surana, Aashima Dabas, V Sreenivas, M Ashraf Gaine, Nandita Gupta
OBJECTIVE: To determine the age of pubertal onset and menarche in school-going girls, and to assess the impact of obesity on pubertal timing. DESIGN: Cross-sectional. SETTING: Seven schools across Delhi, India. PARTICIPANTS: 2010 school girls, aged 6-17 years. METHODS: Anthropometric measurement and pubertal staging was performed for all subjects. Menarche was recorded by status quo method. Body mass index was used to define overweight/obesity...
May 8, 2016: Indian Pediatrics
Vinícius Nahime Brito, Angela Maria Spinola-Castro, Cristiane Kochi, Cristiane Kopacek, Paulo César Alves da Silva, Gil Guerra-Júnior
Clinical and laboratory diagnosis and treatment of central precocious puberty (CPP) remain challenging due to lack of standardization. The aim of this revision was to address the diagnostic and therapeutic features of CPP in Brazil based on relevant international literature and availability of the existing therapies in the country. The diagnosis of CPP is based mainly on clinical and biochemical parameters, and a period of follow-up is desirable to define the "progressive" form of sexual precocity. This occurs due to the broad spectrum of pubertal development, including isolated premature thelarche, constitutional growth and puberty acceleration, progressive and nonprogressive CPP, and early puberty...
April 2016: Archives of Endocrinology and Metabolism
Annalisa Deodati, Alessia Sallemi, Francesca Maranghi, Daniela Germani, Antonella Puglianiello, Francesca Baldari, Luca Busani, Francesca Romana Mancini, Roberta Tassinari, Alberto Mantovani, Stefano Cianfarani
BACKGROUND/AIMS: Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between the exposure to PBDEs and alterations of puberty in girls referred for idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: A case-control study was conducted in 124 girls: 37 girls with ICPP (mean age 7.4 ± 0...
2016: Hormone Research in Pædiatrics
Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen, Niels Holtum Birkebæk
BACKGROUND: Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two diagnoses. METHODS: One hundred ninety-one girls aged 0.5-7 years were included. Diagnoses were validated and the girls were categorized to the groups PP (n = 27) and PT (n = 164). Anthropometry, Tanner stages, ethnicity, bone age, and biochemistry, were recorded...
2016: International Journal of Pediatric Endocrinology
Sang Heon Lee, Eun Young Joo, Ji-Eun Lee, Yong-Hoon Jun, Mi-Young Kim
The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for differentiating central precocious puberty (CPP) from exaggerated thelarche (ET). Because of this test's limitations, previous studies have clarified the clinical and laboratory factors that predict CPP. The present study investigated the early diagnostic significance of pelvic ultrasound in girls with CPP. The GnRH stimulation test and pelvic ultrasound were performed between March 2007 and February 2015 in 192 girls (aged <8 years) with signs of early puberty and advanced bone age...
January 2016: Chonnam Medical Journal
Jason A Wilken, Louise C Greenspan, Lawrence H Kushi, Robert W Voss, Gayle C Windham
BACKGROUND: Pubertal timing is regulated by a complex interplay of hormones. Few studies have evaluated the role of thyroid hormones in pubertal onset. We investigated the associations between blood concentrations of free and total thyroxine (FT4, TT4), free triiodothyronine, and thyroid stimulating hormone and pubertal onset among females. METHODS: Participants included 323 Kaiser Permanente Northern California members followed at annual intervals during 2004-11, who provided a blood sample during the first 3 years of the study...
May 2016: Paediatric and Perinatal Epidemiology
Avni Kaya, Zerrin Orbak, Harun Polat, Atilla Çayır, Abdullah Erdil, Hakan Döneray
OBJECTIVE: Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement. METHODS: Plasma kisspeptin levels and other related biochemical variables were investigated in this prospective study conducted on 40 (20 girls and 20 boys) newborn infants with breast enlargement and on 40 healthy control infants (20 girls and 20 boys)...
September 2015: Journal of Clinical Research in Pediatric Endocrinology
Jung Yu, Ha Young Shin, Sun Hee Lee, You Sung Kim, Jae Hyun Kim
PURPOSE: It is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development. METHODS: This study included girls with early breast development who visited the clinic between January 2012 and December 2013. Clinical, laboratory, and pelvic ultrasonographic data were evaluated...
August 2015: Korean Journal of Pediatrics
Ana Pereira, Camila Corvalán, Ricardo Uauy, Karen O Klein, Verónica Mericq
OBJECTIVE: Prepubertal estradiol equivalents have been inconsistently linked to age at thelarche; elucidating this relationship becomes relevant given the worldwide decline in the age of puberty onset. Thus, our aim is to assess whether prepubertal girls with higher serum levels of estradiol equivalents at age 7 have a greater risk of presenting early thelarche (ET). DESIGN: Nested case-control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (∼50% girls) from Santiago, Chile...
December 2015: European Journal of Endocrinology
Alejandro Diaz, Laura Luque, Zain Badar, Steve Kornic, Marco Danon
INTRODUCTION: Prepubertal gynecomastia is a rare condition characterized by the growth of breast tissue in males as a consequence of early exposure to sexual hormones. When this condition is present, pathological sources of testosterone/estrogen production, such as adrenal or gonadal tumors must be searched for. A few reports have described an association between gynecomastia and substances that produce stimulation of the estrogen receptor, such as lavender and tea tree oil. METHODS: Here we describe the cases of three boys who presented with prepubertal gynecomastia and were chronically exposed to lavender...
January 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
R Waelchli, J Williams, T Cole, M Dattani, P Hindmarsh, H Kennedy, A Martinez, S Khan, R K Semple, A White, N Sebire, E Healy, G Moore, V A Kinsler
BACKGROUND: Multiple congenital melanocytic naevi (CMN) is a rare mosaic RASopathy, caused by postzygotic activating mutations in NRAS. Growth and hormonal disturbances are described in germline RASopathies, but growth and hormone status have not previously been investigated in individuals with CMN. OBJECTIVES: To explore premature thelarche, undescended testes, and a clinically abnormal fat distribution with CMN through prospective endocrinological assessment of a cohort of subjects with CMN, and a retrospective review of longitudinal growth of a larger group of patients with CMN from outpatient clinics (which included all subjects in the endocrinological assessment group)...
December 2015: British Journal of Dermatology
Nursel Muratoglu Sahin, Sibel Tulgar Kinik, Mustafa Agah Tekindal, Nilufer Bayraktar
BACKGROUND: The possible difference of antimüllerian hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated. OBJECTIVE/HYPOTHESIS: By evaluating AMH levels in girls with diagnosed CPP and PT, we aim to show the change of AMH levels at the pubertal onset. SUBJECTS: Sixty-five girls who have breast development before the age of 8 years and 25 healthy girls were enrolled in the study...
November 1, 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
Alina German, Michael Shmoish, Ze'ev Hochberg
BACKGROUND: Despite substantial heritability in pubertal development, children differ in maturational tempo. HYPOTHESES: (i) puberty and its duration are influenced by early changes in height and adiposity. (ii) Adiposity rebound (AR) is a marker for pubertal tempo. METHODS: We utilized published prospective data from 659 girls and 706 boys of the Study of Early Child Care and Youth Development. We investigated the age of pubarche-thelarche-gonadarche-menarche as a function of early height, BMI, and AR...
October 2015: Pediatric Research
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