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https://www.readbyqxmd.com/read/28073532/toxigenic-algae-and-associated-phycotoxins-in-two-coastal-embayments-in-the-ebro-delta-nw-mediterranean
#1
Julia A Busch, Karl B Andree, Jorge Diogène, Margarita Fernández-Tejedor, Kerstin Toebe, Uwe John, Bernd Krock, Urban Tillmann, Allan D Cembella
Harmful Algal Bloom (HAB) surveillance is complicated by high diversity of species and associated phycotoxins. Such species-level information on taxonomic affiliations and on cell abundance and toxin content is, however, crucial for effective monitoring, especially of aquaculture and fisheries areas. The aim addressed in this study was to determine putative HAB taxa and related phycotoxins in plankton from aquaculture sites in the Ebro Delta, NW Mediterranean. The comparative geographical distribution of potentially harmful plankton taxa was established by weekly field sampling throughout the water column during late spring-early summer over two years at key stations in Alfacs and Fangar embayments within the Ebro Delta...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28041686/evaluation-of-a-commercially-available-hyaluronic-acid-hydrogel-restylane-as-injectable-scaffold-for-dental-pulp-regeneration-an-in%C3%A2-vitro-evaluation
#2
Vanessa Chrepa, Obadah Austah, Anibal Diogenes
INTRODUCTION: Regenerative endodontic procedures (REPs) are viable alternatives for treating immature teeth, yet these procedures do not predictably lead to pulp-dentin regeneration. A true bioengineering approach for dental pulp regeneration requires the incorporation of a scaffold conducive with the regeneration of the pulp-dentin complex. Several materials have been proposed as scaffolds for REPs; nonetheless, the majority are not eligible for immediate clinical chairside use. Thus, the aim of this study was to evaluate Restylane, a Food and Drug Administration-approved hyaluronic acid-based gel, as possible scaffold for REPs...
December 29, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28024953/immune-protection-conferred-by-recombinant-mrlc-myosin-regulatory-light-chain-antigen-in-titermax-gold%C3%A2-adjuvant-against-experimental-fasciolosis-in-rats
#3
Luan C Henker, Claiton I Schwertz, Neuber J Lucca, Manoela M Piva, Keila C Prior, Piotr Baska, Luke Norbury, Kamil Januszkiewicz, Diogenes Dezen, Marta M M F Duarte, Rafael N Moresco, Liana Bertagnolli da Rosa, Ricardo E Mendes
Protection against experimental fasciolosis in rats immunized with recombinant myosin regulatory light chain (MRLC) in TiterMax Gold® adjuvant was assessed. The experimental trial consisted of four groups of 15 animals; group 1 was unimmunized and infected, group 2 was immunized with MRLC in adjuvant and infected, group 3 was infected and immunized with adjuvant only and group 4 was unimmunized and uninfected. Immunization with MRLC in TiterMax Gold® adjuvant (group 2) induced a reduction in fluke burdens of 51...
December 23, 2016: Vaccine
https://www.readbyqxmd.com/read/28009804/evaluation-of-chemical-composition-and-antileishmanial-and-antituberculosis-activities-of-essential-oils-of-piper-species
#4
Karine Zanoli Bernuci, Camila Cristina Iwanaga, Carla Maria Mariano Fernandez-Andrade, Fabiana Brusco Lorenzetti, Eduardo Caio Torres-Santos, Viviane Dos Santos Faiões, José Eduardo Gonçalves, Wanderlei do Amaral, Cícero Deschamps, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Vanessa Pietrowski Baldin, Diógenes Aparício Garcia Cortez
Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC-MS), and a total of 68 components were identified. Principal components analysis results showed a chemical variability between species, with sesquiterpene compounds predominating in the majority of species analyzed. The composition of the essential oil of Piper mosenii was described for the first time. The cytotoxicity of the essential oils was evaluated in peritoneal macrophages and the oils of P...
December 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28000057/bovine-in-vitro-embryo-production-the-effects-of-fibroblast-growth-factor-10-fgf10
#5
Mateus Nunes Diógenes, Ana Luiza Silva Guimarães, Ligiane Oliveira Leme, Margot Alves Nunes Dode
PURPOSE: In an attempt to improve in vitro embryo production, we investigated the effect of fibroblast growth factor 10 (FGF10) during in vitro maturation on the developmental capacity of bovine oocytes. MATERIAL AND METHODS: Cumulus-oocyte complexes (COCs) were aspirated from follicles of 3-8 mm diameter. After selection, the COCs were matured in medium with or without 0.5 ng/mL of FGF10. The effect of FGF10 during in vitro maturation (IVM) on nuclear maturation kinetics and expansion of the cumulus cells was investigated...
December 20, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27988534/a-new-species-of-the-genus-i-diogenes-i-dana-1851-crustacea-decapoda-anomura-diogenidae-from-gujarat-northwestern-india
#6
Jigneshkumar N Trivedi, Masayuki Osawa, Kauresh D Vachhrajani
A new species of diogenid hermit crab, Diogenes chhapgari n. sp., is described on the basis of material collected during the crustacean faunal survey along the coastal areas of the Gujarat State, northwestern India. The new species is referred to the D. edwardsii (De Haan, 1849) species group and appears closest to D. singaporensis Rahayu, 2015. However, D. chhapgari n. sp. is distinguished from this species by the armature on the fourth segment of the antennal peduncle and carpus of the left cheliped.
December 15, 2016: Zootaxa
https://www.readbyqxmd.com/read/27973453/evaluation-of-chemical-composition-and-antileishmanial-and-antituberculosis-activities-of-essential-oils-of-piper-species
#7
Karine Zanoli Bernuci, Camila Cristina Iwanaga, Carla Maria Mariano Fernadez-Andrade, Fabiana Brusco Lorenzetti, Eduardo Caio Torres-Santos, Viviane Dos Santos Faiões, José Eduardo Gonçalves, Wanderlei do Amaral, Cícero Deschamps, Regiane Bertin de Lima Scodro, Rosilene Fressatti Cardoso, Vanessa Pietrowski Baldin, Diógenes Aparício Garcia Cortez
Essential oils from fresh Piperaceae leaves were obtained by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC-MS), and a total of 68 components were identified. Principal components analysis results showed a chemical variability between species, with sesquiterpene compounds predominating in the majority of species analyzed. The composition of the essential oil of Piper mosenii was described for the first time. The cytotoxicity of the essential oils was evaluated in peritoneal macrophages and the oils of P...
December 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27914363/new-insights-into-the-sar-and-drug-combination-synergy-of-2-quinolin-4-yloxy-acetamides-against-mycobacterium-tuberculosis
#8
Bruno Couto Giacobbo, Kenia Pissinate, Valnês Rodrigues-Junior, Anne Drumond Villela, Estêvão Silveira Grams, Bruno Lopes Abbadi, Fernanda Teixeira Subtil, Nathalia Sperotto, Rogério Valim Trindade, Davi Fernando Back, Maria Martha Campos, Luiz Augusto Basso, Pablo Machado, Diógenes Santiago Santos
2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) values against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains in the submicromolar range. Furthermore, the most active compounds had no apparent toxicity to mammalian cells, and they showed intracellular activities similar to those of isoniazid and rifampin in a macrophage model of Mtb infection...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27912813/regenerative-endodontic-procedures-clinical-outcomes
#9
REVIEW
Anibal Diogenes, Nikita B Ruparel
Immature teeth are at risk for pulp necrosis, resulting in arrested root development and poor long-term prognosis. There is growing evidence that regenerative endodontic procedures promote desirable clinical outcomes. Despite significant advances in the field of regenerative endodontics and acceptable clinical outcomes, current evidence suggests that the tissues formed following currently used procedures do not completely recapitulate the former pulp-dentin complex. Further research is needed to identify prognostic factors and predictors of successful outcomes and to develop different treatment strategies to better predictably achieve all identified clinical outcomes, while favoring tissue formation that more closely resembles the pulp-dentin complex...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27906997/role-of-genetic-polymorphisms-in-the-development-and-prognosis-of-sporadic-and-familial-prostate-cancer
#10
Sabrina T Reis, Nayara I Viana, Katia R M Leite, Erico Diogenes, Alberto A Antunes, Alexandre Iscaife, Adriano J Nesrallah, Carlo C Passerotti, Victor Srougi, José Pontes-Junior, Mary Ellen Salles, William C Nahas, Miguel Srougi
BACKGROUNDS: Our aim was to evaluate the role of 20 genetic polymorphisms in the development and prognosis of sporadic and familial PC. A case-control study of 185 patients who underwent radical prostatectomy from 1997 to 2011. These patients were divided into two groups based on their family history. Gleason grade, PSA value and pathological TNM 2002 stage were used as prognostic factors. Blood samples from 70 men without PC were used as controls. The SNPs were genotyped using a TaqMan® SNP Genotyping Assay Kit...
2016: PloS One
https://www.readbyqxmd.com/read/27903722/adenosine-kinase-deficiency-in-the-brain-results-in-maladaptive-synaptic-plasticity
#11
Ursula S Sandau, Mariana Colino-Oliveira, Abbie Jones, Bounmy Saleumvong, Shayla Q Coffman, Long Liu, Catarina Miranda-Lourenço, Cátia Palminha, Vânia L Batalha, Yiming Xu, Yuqing Huo, Maria J Diógenes, Ana M Sebastião, Detlev Boison
: Adenosine kinase (ADK) deficiency in human patients (OMIM:614300) disrupts the methionine cycle and triggers hypermethioninemia, hepatic encephalopathy, cognitive impairment, and seizures. To identify whether this neurological phenotype is intrinsically based on ADK deficiency in the brain or if it is secondary to liver dysfunction, we generated a mouse model with a brain-wide deletion of ADK by introducing a Nestin-Cre transgene into a line of conditional ADK deficient Adk(fl/fl) mice...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27889488/enhanced-ltp-in-aged-rats-detrimental-or-compensatory
#12
Júlia Pinho, Ruben Vale, Vânia L Batalha, Ana Rita Costenla, Raquel Dias, Diogo Rombo, Ana M Sebastião, Alexandre de Mendonça, Maria José Diógenes
Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats. Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 μM, 4 h), and hippocampal LTP was evaluated. The results show that memantine significantly decreases the larger LTP magnitude recorded in hippocampal slices from aged rats without compromising LTP recorded in slices from young and adult animals...
March 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27888112/satellite-cell-activation-induced-by-aerobic-muscle-adaptation-in-response-to-endurance-exercise-in-humans-and-rodents
#13
REVIEW
Phablo Abreu, Sávio Victor Diógenes Mendes, Vânia Marilande Ceccatto, Sandro Massao Hirabara
Although the requirement of satellite cells activation and expansion following injury, mechanical load or growth stimulus provoked by resistance exercise has been well established, their function in response to aerobic exercise adaptation remains unclear. A clear relationship between satellite cell expansion in fiber-type specific myosin heavy chain and aerobic performance has been related, independent of myonuclear accretion or muscle growth. However, the trigger for this activation process is not fully understood yet and it seems to be a multi-faceted and well-orchestrated process...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27880844/atorvastatin-improves-ventricular-remodeling-after-myocardial-infarction-by-interfering-with-collagen-metabolism
#14
Karla Reichert, Helison Rafael Pereira do Carmo, Anali Galluce Torina, Daniela Diógenes de Carvalho, Andrei Carvalho Sposito, Karlos Alexandre de Souza Vilarinho, Lindemberg da Mota Silveira-Filho, Pedro Paulo Martins de Oliveira, Orlando Petrucci
PURPOSE: Therapeutic strategies that modulate ventricular remodeling can be useful after acute myocardial infarction (MI). In particular, statins may exert effects on molecular pathways involved in collagen metabolism. The aim of this study was to determine whether treatment with atorvastatin for 4 weeks would lead to changes in collagen metabolism and ventricular remodeling in a rat model of MI. METHODS: Male Wistar rats were used in this study. MI was induced in rats by ligation of the left anterior descending coronary artery (LAD)...
2016: PloS One
https://www.readbyqxmd.com/read/27868275/effectiveness-and-safety-of-drugs-used-for-stroke-prevention-in-a-cohort-of-non-valvular-atrial-fibrillation-patients-from-a-primary-care-electronic-database
#15
Maria Giner-Soriano, Albert Roso-Llorach, Cristina Vedia Urgell, Xavier Castells, Dolors Capellà, Ignacio Ferreira-González, Josep Maria Elorza-Ricart, Marc Casajuana, Amelia Troncoso Mariño, Eduard Diògene, Bonaventura Bolíbar, Concepció Violan, Rosa Morros
PURPOSE: The aim of this study was to assess effectiveness and safety of antithrombotics for stroke prevention in non-valvular atrial fibrillation in real-use conditions. METHODS: We used a population-based retrospective cohort study. Information emerges from SIDIAP, a database containing anonymized information from electronic health records from 274 primary healthcare centres of the Catalan Health Institute, Catalonia (Spain), with a reference population of 5 835 000 people...
November 20, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27818554/breast-cancer-with-splenic-metastasis-in-a-male-patient
#16
Bruna Maria Thompson, Flávio Ferrarini de Oliveira Pimentel, Jaime Afonso Coelho Nogueira Diógenes, Marcelo Hajime Kohayagawa, Maria Regina Vianna
No abstract text is available yet for this article.
September 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27812632/effects-of-passive-inhalation-of-cigarette-smoke-on-structural-and-functional-parameters-in-the-respiratory-system-of-guinea-pigs
#17
Thiago Brasileiro de Vasconcelos, Fernanda Yvelize Ramos de Araújo, João Paulo Melo de Pinho, Pedro Marcos Gomes Soares, Vasco Pinheiro Diógenes Bastos
Objective: To evaluate the effects of passive inhalation of cigarette smoke on the respiratory system of guinea pigs. Methods: Male guinea pigs were divided into two groups: control and passive smoking, the latter being exposed to the smoke of ten cigarettes for 20 min in the morning, afternoon and evening (30 cigarettes/day) for five days. After that period, inflammatory parameters were studied by quantifying mesenteric mast cell degranulation, as well as oxidative stress, in BAL fluid...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27769382/development-validation-and-application-of-a-96-well-enzymatic-assay-based-on-lc-esi-ms-ms-quantification-for-the-screening-of-selective-inhibitors-against-mycobacterium-tuberculosis-purine-nucleoside-phosphorylase
#18
Giulia Cattaneo, Daniela Ubiali, Enrica Calleri, Marco Rabuffetti, Georg C Höfner, Klaus T Wanner, Marcela C De Moraes, Leonardo K B Martinelli, Diógenes Santiago Santos, Giovanna Speranza, Gabriella Massolini
Mycobacterium tuberculosis (Mtb) purine nucleoside phosphorylase (PNP, EC 2.4.2.1) has been identified as a target for the development of specific inhibitors with potential antimycobacterial activity. We hereby described the development and validation of a new 96-well LC-ESI-MS/MS method to assess the inhibition activity of nucleoside analogues towards MtbPNP and the human PNP (HsPNP). Enzyme activity was determined by monitoring the phosphorolysis of inosine (Ino) to hypoxanthine (Hpx). The enzymatic assay (v = 0...
November 2, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27748220/effect-of-insulin-transferrin-selenium-its-and-l-ascorbic-acid-aa-during-in-vitro-maturation-on-in-vitro-bovine-embryo-development
#19
A L S Guimarães, S A Pereira, M N Diógenes, M A N Dode
The aim of this study was to evaluate the effect of adding a combination of insulin, transferrin and selenium (ITS) and l-ascorbic acid (AA) during in vitro maturation (IVM) and in vitro culture (IVC) on in vitro embryo production. To verify the effect of the supplements, cleavage and blastocyst rates, embryo size and total cell number were performed. Embryonic development data, embryo size categorization and kinetics of maturation were analyzed by chi-squared test, while the total cell number was analyzed by a Kruskal-Wallis test (P < 0...
December 2016: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/27733828/payers-views-of-the-changes-arising-through-the-possible-adoption-of-adaptive-pathways
#20
Michael Ermisch, Anna Bucsics, Patricia Vella Bonanno, Francis Arickx, Alexander Bybau, Tomasz Bochenek, Marc van de Casteele, Eduardo Diogene, Jurij Fürst, Kristina Garuolienė, Martin van der Graaff, Jolanta Gulbinovič, Alan Haycox, Jan Jones, Roberta Joppi, Ott Laius, Irene Langner, Antony P Martin, Vanda Markovic-Pekovic, Laura McCullagh, Einar Magnusson, Ellen Nilsen, Gisbert Selke, Catherine Sermet, Steven Simoens, Robert Sauermann, Ad Schuurman, Ricardo Ramos, Vera Vlahovic-Palcevski, Corinne Zara, Brian Godman
Payers are a major stakeholder in any considerations and initiatives concerning adaptive licensing of new medicinal products, also referred to as Medicines Adaptive Pathways to patients (MAPPs). Firstly, the scope and necessity of MAPPs need further scrutiny, especially with regard to the definition of unmet need. Conditional approval pathways already exist for new medicines for seriously debilitating or life-threatening diseases and only a limited number of new medicines are innovative. Secondly, MAPPs will result in new medicines on the market with limited evidence about their effectiveness and safety...
2016: Frontiers in Pharmacology
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