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https://www.readbyqxmd.com/read/29347842/in-vitro-antioxidant-potential-and-in-vivo-effects-of-schinus-terebinthifolia-raddi-leaf-extract-in-diabetic-rats-and-determination-of-chemical-composition-by-hplc-esi-ms-ms
#1
Camila Cristina Iwanaga, Lilian Dos Anjos Oliveira Ferreira, Karine Zanoli Bernuci, Carla Maria Mariano Fernandez, Fabiana Brusco Lorenzetti, Camila Caviquioli Sehaber, Flávia Cristina Vieira Frez, Sara Santos Bernardes, Gean Pier Panizzon, Giani Andrea Linde, Maria do Carmo Vieira, Jacqueline Nelisis Zanoni, Diógenes Aparício Garcia Cortez
The present study investigated the in vitro and in vivo antioxidant potential and phytochemical composition of Schinus terebinthifolia, which is widely used in folk medicine for various therapeutic purposes. The in vitro analyses indicated that the hydroethanolic extract (HE) had 312.50 ± 0.50 mg GAE/g of total phenols. It also presented anti-DPPH• and anti-ABTS•+ activity, reduced phosphomolybden and metal ions and blocked the bleaching of β-carotene. The HE at concentrations of 3.0 and 2.0 μg/mL had TRAP values of 2...
January 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29343741/species-distribution-modelling-contrasting-presence-only-models-with-plot-abundance-data
#2
Vitor H F Gomes, Stéphanie D IJff, Niels Raes, Iêda Leão Amaral, Rafael P Salomão, Luiz de Souza Coelho, Francisca Dionízia de Almeida Matos, Carolina V Castilho, Diogenes de Andrade Lima Filho, Dairon Cárdenas López, Juan Ernesto Guevara, William E Magnusson, Oliver L Phillips, Florian Wittmann, Marcelo de Jesus Veiga Carim, Maria Pires Martins, Mariana Victória Irume, Daniel Sabatier, Jean-François Molino, Olaf S Bánki, José Renan da Silva Guimarães, Nigel C A Pitman, Maria Teresa Fernandez Piedade, Abel Monteagudo Mendoza, Bruno Garcia Luize, Eduardo Martins Venticinque, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Angelo Gilberto Manzatto, John Terborgh, Neidiane Farias Costa Reis, Juan Carlos Montero, Katia Regina Casula, Beatriz S Marimon, Ben-Hur Marimon, Euridice N Honorio Coronado, Ted R Feldpausch, Alvaro Duque, Charles Eugene Zartman, Nicolás Castaño Arboleda, Timothy J Killeen, Bonifacio Mostacedo, Rodolfo Vasquez, Jochen Schöngart, Rafael L Assis, Marcelo Brilhante Medeiros, Marcelo Fragomeni Simon, Ana Andrade, William F Laurance, José Luís Camargo, Layon O Demarchi, Susan G W Laurance, Emanuelle de Sousa Farias, Henrique Eduardo Mendonça Nascimento, Juan David Cardenas Revilla, Adriano Quaresma, Flavia R C Costa, Ima Célia Guimarães Vieira, Bruno Barçante Ladvocat Cintra, Hernán Castellanos, Roel Brienen, Pablo R Stevenson, Yuri Feitosa, Joost F Duivenvoorden, Gerardo A Aymard C, Hugo F Mogollón, Natalia Targhetta, James A Comiskey, Alberto Vicentini, Aline Lopes, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Carolina Levis, Juliana Schietti, Priscila Souza, Thaise Emilio, Alfonso Alonso, David Neill, Francisco Dallmeier, Leandro Valle Ferreira, Alejandro Araujo-Murakami, Daniel Praia, Dário Dantas do Amaral, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth Feeley, Luzmila Arroyo, Marcelo Petratti Pansonato, Rogerio Gribel, Boris Villa, Juan Carlos Licona, Paul V A Fine, Carlos Cerón, Chris Baraloto, Eliana M Jimenez, Juliana Stropp, Julien Engel, Marcos Silveira, Maria Cristina Peñuela Mora, Pascal Petronelli, Paul Maas, Raquel Thomas-Caesar, Terry W Henkel, Doug Daly, Marcos Ríos Paredes, Tim R Baker, Alfredo Fuentes, Carlos A Peres, Jerome Chave, Jose Luis Marcelo Pena, Kyle G Dexter, Miles R Silman, Peter Møller Jørgensen, Toby Pennington, Anthony Di Fiore, Fernando Cornejo Valverde, Juan Fernando Phillips, Gonzalo Rivas-Torres, Patricio von Hildebrand, Tinde R van Andel, Ademir R Ruschel, Adriana Prieto, Agustín Rudas, Bruce Hoffman, César I A Vela, Edelcilio Marques Barbosa, Egleé L Zent, George Pepe Gallardo Gonzales, Hilda Paulette Dávila Doza, Ires Paula de Andrade Miranda, Jean-Louis Guillaumet, Linder Felipe Mozombite Pinto, Luiz Carlos de Matos Bonates, Natalino Silva, Ricardo Zárate Gómez, Stanford Zent, Therany Gonzales, Vincent A Vos, Yadvinder Malhi, Alexandre A Oliveira, Angela Cano, Bianca Weiss Albuquerque, Corine Vriesendorp, Diego Felipe Correa, Emilio Vilanova Torre, Geertje van der Heijden, Hirma Ramirez-Angulo, José Ferreira Ramos, Kenneth R Young, Maira Rocha, Marcelo Trindade Nascimento, Maria Natalia Umaña Medina, Milton Tirado, Ophelia Wang, Rodrigo Sierra, Armando Torres-Lezama, Casimiro Mendoza, Cid Ferreira, Cláudia Baider, Daniel Villarroel, Henrik Balslev, Italo Mesones, Ligia Estela Urrego Giraldo, Luisa Fernanda Casas, Manuel Augusto Ahuite Reategui, Reynaldo Linares-Palomino, Roderick Zagt, Sasha Cárdenas, William Farfan-Rios, Adeilza Felipe Sampaio, Daniela Pauletto, Elvis H Valderrama Sandoval, Freddy Ramirez Arevalo, Isau Huamantupa-Chuquimaco, Karina Garcia-Cabrera, Lionel Hernandez, Luis Valenzuela Gamarra, Miguel N Alexiades, Susamar Pansini, Walter Palacios Cuenca, William Milliken, Joana Ricardo, Gabriela Lopez-Gonzalez, Edwin Pos, Hans Ter Steege
Species distribution models (SDMs) are widely used in ecology and conservation. Presence-only SDMs such as MaxEnt frequently use natural history collections (NHCs) as occurrence data, given their huge numbers and accessibility. NHCs are often spatially biased which may generate inaccuracies in SDMs. Here, we test how the distribution of NHCs and MaxEnt predictions relates to a spatial abundance model, based on a large plot dataset for Amazonian tree species, using inverse distance weighting (IDW). We also propose a new pipeline to deal with inconsistencies in NHCs and to limit the area of occupancy of the species...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340871/neurotoxicity-of-prosopis-juliflora-from-natural-poisoning-to-mechanism-of-action-of-its-piperidine-alkaloids
#3
Victor Diogenes Amaral da Silva, André Mario Mendes da Silva, Juliana Helena Castro E Silva, Silvia Lima Costa
Prosopis juliflora was introduced in northeastern Brazil in the 1940s, and since then, it has been available as an alternative for animal nutrition. However, the consumption of P. juliflora as main or sole source of food causes an illness in animals known locally as "cara torta" disease. Cattle and goats experimentally intoxicated presents neurotoxic damage in the central nervous system. Histologic lesions were mainly characterized by vacuolation and loss of neurons in trigeminal motor nuclei. Furthermore, mitochondrial damage in neurons and gliosis was reported in trigeminal nuclei of intoxicated cattle...
January 16, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29281707/inhibitory-activity-of-pentacyano-isoniazid-ferrate-ii-iqg-607-against-promastigotes-and-amastigotes-forms-of-leishmania-braziliensis
#4
Camila F Amorim, Luiza Galina, Natália B Carvalho, Nathalia D M Sperotto, Kenia Pissinate, Pablo Machado, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior, Edgar M Carvalho, Diógenes Santiago Santos
M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M. tuberculosis, a key component in the FASII system. Here, we aimed to evaluate the inhibitory activity of IQG-607 against promastigote and amastigote forms of Leishmania (Viannia) braziliensis isolated from patients with different clinical forms of L. braziliensis infection, including cutaneous, mucosal and disseminated leishmaniasis...
2017: PloS One
https://www.readbyqxmd.com/read/29248247/infralittoral-sublittoral-submerged-zone-macroinfauna-community-structure-of-high-impact-medium-impact-and-non-impact-beaches-on-the-gulf-of-c%C3%A3-diz-coast-sw-spain-evaluation-of-anthropogenic-alterations-nourishments-human-impact-and-urbanization
#5
R Muñoz-Lechuga, M Gutiérrez-Martínez, V Sanz-Fernández, A Gómez-Cabeza, R Cabrera-Castro
Beaches are dynamic transitional environments subject to numerous natural and anthropic alterations. In these ecosystems, the infralittoral-sublittoral macrofauna communities play a key role in the food web. The objective of this study was to compare macrofauna communities on six beaches on the Gulf of Cádiz coast, which were classified according to the anthropic alterations they support, and evaluate the influence of abiotic factors on the species distribution. Sampling was done in the infralittoral-sublittoral zone of each beach using a modified manual dredge...
December 7, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29220718/spatial-and-temporal-dynamics-of-pathogenic-leptospira-in-surface-waters-from-the-urban-slum-environment
#6
Arnau Casanovas-Massana, Federico Costa, Irina N Riediger, Marcelo Cunha, Daiana de Oliveira, Diogenes C Mota, Erica Sousa, Vladimir A Querino, Nivisson Nery, Mitermayer G Reis, Elsio A Wunder, Peter J Diggle, Albert I Ko
Leptospirosis has emerged as an important urban health problem as slum settlements have expanded worldwide. Yet the dynamics of the environmentally transmitted Leptospira pathogen has not been well characterized in these settings. We used a stratified dense sampling scheme to study the dynamics of Leptospira abundance in surface waters from a Brazilian urban slum community. We collected surface water samples during the dry, intermediate and rainy seasons within a seven-month period and quantified pathogenic Leptospira by quantitative PCR (qPCR)...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29211027/dietary-intake-of-protein-from-different-sources-and-weight-regain-changes-in-body-composition-and-cardiometabolic-risk-factors-after-weight-loss-the-diogenes-study
#7
Marleen A van Baak, Thomas M Larsen, Susan A Jebb, Alfredo Martinez, Wim H M Saris, Teodora Handjieva-Darlenska, Anthony Kafatos, Andreas F H Pfeiffer, Marie Kunešová, Arne Astrup
An increase in dietary protein intake has been shown to improve weight loss maintenance in the DIOGenes trial. Here, we analysed whether the source of the dietary proteins influenced changes in body weight, body composition, and cardiometabolic risk factors during the weight maintenance period while following an energy-restricted diet. 489 overweight or obese participants of the DIOGenes trial from eight European countries were included. They successfully lost >8% of body weight and subsequently completed a six month weight maintenance period, in which they consumed an ad libitum diet varying in protein content and glycemic index...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29197280/occurrence-of-cyclic-imines-in-european-commercial-seafood-and-consumers-risk-assessment
#8
Maria Rambla-Alegre, Christopher O Miles, Pablo de la Iglesia, Margarita Fernandez-Tejedor, Silke Jacobs, Isabelle Sioen, Wim Verbeke, Ingunn A Samdal, Morten Sandvik, Vera Barbosa, Alice Tediosi, Eneko Madorran, Kit Granby, Michiel Kotterman, Tanja Calis, Jorge Diogene
Cyclic imines constitute a quite recently discovered group of marine biotoxins that act on neural receptors and that bioaccumulate in seafood. They are grouped together due to the imino group functioning as their common pharmacore, responsible for acute neurotoxicity in mice. Cyclic imines (CIs) have not been linked yet to human poisoning and are not regulated in the European Union (EU), although the European Food Safety Authority (EFSA) requires more data to perform conclusive risk assessment for consumers...
November 29, 2017: Environmental Research
https://www.readbyqxmd.com/read/29179846/-supporting-people-with-diogenes-syndrome
#9
REVIEW
Claire Patry, Sylvain Closier, Élise Lafon, Corine Carlier-Verhaeghe, Angélique Kerrien, Armelle Bertrand, Emmanuelle Caudron
Diogenes syndrome is a chronic condition often affecting elderly people, especially those living in isolation. It is characterised by self-neglect and compulsive hoarding. Medico-social professionals working with people in their home, have reflected on levers to help improve the complex support of these patients.
December 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/29174400/self-assembled-monolayer-based-immunoassays-for-okadaic-acid-detection-in-seawater-as-monitoring-tools
#10
Sandra Leonardo, Anna Toldrà, Maria Rambla-Alegre, Margarita Fernández-Tejedor, Karl B Andree, Laura Ferreres, Katrina Campbell, Christopher T Elliott, Ciara K O'Sullivan, Yolanda Pazos, Jorge Diogène, Mònica Campàs
Rapid and cost-effective methods to monitor the presence of diarrhetic shellfish poisoning (DSP) toxins in seawater samples in an easy and reliable manner are required to protect human health and avoid economic losses to shellfish industry. Immunoassays for the detection of okadaic acid (OA) and dinophysistoxin-1 and dinophysistoxin-2 are developed by immobilising OA on self-assembled monothiols or dithiols in an ordered and oriented way, providing an effective limit of detection of ∼1 ng OA equiv./mL seawater...
November 14, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29160359/gastrointestinal-parasites-in-feral-cats-and-rodents-from-the-fernando-de-noronha-archipelago-brazil
#11
Victor Fernando Santana Lima, Rafael Antonio Nascimento Ramos, Raphael Lepold, João Carlos Gomes Borges, Carlos Diógenes Ferreira, Laura Rinaldi, Giuseppe Cringoli, Leucio Câmara Alves
Gastrointestinal parasites are important pathogens affecting animals, some of them are of medical and veterinary concern. Although the dynamic of parasitic infections is a complex phenomenon that has been studied under experimental conditions, it shows several gaps in knowledge, especially in insular regions where a confined population of animals and parasites co-exists. In this study was assessed the parasitism by endoparasite gastrointestinal in feral cats (n = 37) and rodents (n = 30) from the Fernando de Noronha Archipelago; in addition, the risk of human infection and ecological implications of these findings were discussed...
November 9, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29158273/revisiting-activation-of-and-the-mechanism-of-resistance-to-the-compound-iqg-607-in-mycobacterium-tuberculosis
#12
Bruno L Abbadi, Anne D Villela, Valnês S Rodrigues-Junior, Fernanda T Subtil, Pedro F Dalberto, Ana P S Pinheiro, Diógenes S Santos, Pablo Machado, Luiz A Basso, Cristiano V Bizarro
IQG-607 is a metal complex previously reported as a promising anti-TB drug against isoniazid (INH)-resistant strains of M. tuberculosis Unexpectedly, we found that INH-resistant clinical isolates were resistant to IQG-607. Spontaneous mutants resistant to IQG-607 were subjected to whole-genome sequencing and all sequenced colonies carried alterations in the katG gene. The katG(S315T) mutation was sufficient to confer resistance to IQG-607 in both MIC assays and inside macrophages. Moreover, overexpressing the InhA(S94A) protein caused IQG-607's resistance...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29145187/diogenes-syndrome
#13
Frédéric Assal
Diogenes syndrome (DS) is not a specific disease but a real neurobehavioral syndrome, characterized by severe domestic squalor, pathological hoarding, lack of insight into the condition, and no need for help. DS can be secondary when associated to psychosis or bipolar disorder, or primary when it occurs as a single entity, usually in the elderly. DS is a clinically complex transnosographic syndrome for which multidimensional approaches need to be considered: medical, psychiatric, neurological, social, scientific, and ethical...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29122715/nematicidal-activity-of-a-water-soluble-lectin-from-seeds-of-moringa-oleifera
#14
Mário Luan Silva de Medeiros, Maiara Celine de Moura, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Luana Cassandra Breitenbach Barroso Coelho, Ana Carla Diógenes Suassuna Bezerra, Michele Dalvina Correia da Silva
Gastrointestinal nematodes are the major cause of animal diseases, and the indiscriminate use of synthetic anthelmintic contributes to the development of drug resistance. Natural bioproducts are noteworthy since they have proved to be promising for alternative antiparasitic therapies. This study evaluated the in vitro effect of WSMoL (water soluble Moringa oleifera lectin) on hatching of eggs and on the development of early-stage larvae of gastrointestinal nematodes from naturally infected goats. In addition, the interference of WSMoL on activity of proteases was determined and the affinity of the lectin for glycosylated molecules of these parasites was investigated using fluorescein isothiocyanate (FITC)-labeled WSMoL...
November 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29108463/td-the-case-of-diogenes-syndrome-deficit-or-denial
#15
Fiona Ashworth, Anita Rose, Barbara A Wilson
Diogenes Syndrome (DS) is characterised by extreme self-neglect, domestic squalor, hoarding, social withdrawal, and lack of concern and shame for the individual's residential situation. This paper describes TD who was unable to identify emotional expressions of disgust and was borderline-impaired for facial recognition associated with perceptual difficulties. Problems interpreting expressions of disgust were interesting as TD was living in squalor, neglecting himself, and lacked concern for his circumstances...
November 6, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29091140/construction-of-mycobacterium-tuberculosis-cdd-knockout-and-evaluation-of-invasion-and-growth-in-macrophages
#16
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluation of mRNA expression validated cdd deletion and showed the absence of polar effect. MudPIT LC-MS/MS data indicated thymidine phosphorylase expression was decreased in knockout and complemented strains. The cdd disruption does not affect M...
November 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29072357/piper-regnellii-extract-biopolymer-based-microparticles-production-characterization-and-antifungal-activity
#17
Lara Zampar Serra Brambilla, Eliana Harue Endo, Diógenes Aparício Garcia Cortez, Marli Miriam de Souza Lima, Benedito Prado Dias Filho
AIMS: This study aims to improve characteristics of Piper regnellii extract to make it applicable in formulations to treat dermatophytosis, also known as ringworm. METHODS AND RESULTS: Microparticles were produced by spray-drying with gelatin, alginate and chitosan as encapsulating agents, characterized by scanning electron microscopy, encapsulation efficiency, thermal analyses, X-ray diffraction, and tested against Trichophyton rubrum by broth microdilution. Produced microparticles had a mean diameter less than 2 μm, an increase in stability and release of the extract and good results for encapsulation efficiency, being 85...
October 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29037995/preclinical-pharmacokinetic-profiling-of-iqg-607-a-potential-oral-metallodrug-to-treat-tuberculosis
#18
Adilio da S Dadda, Valnês S Rodrigues-Junior, Fernando Carreño, Guilherme O Petersen, Antônio F M Pinto, Pedro F Dalberto, Nathalia D M Sperotto, Kenia Pissinate, Cristiano V Bizarro, Pablo Machado, Maria M Campos, Teresa Dalla Costa, Diógenes S Santos, Luiz A Basso
IQG-607 is an analog of isoniazid with anti-tuberculosis activity. This work describes the development and validation of an HPLC method to quantify pentacyano(isoniazid)ferrate(II) compound (IQG-607) and the pharmacokinetic studies of this compound in mice. The method showed linearity in the 0.5-50μg/mL concentration range (r=0.9992). Intra- and inter-day precision was <5%, and the recovery ranged from 92.07 to 107.68%. IQG-607 was stable in plasma for at least 30days at -80°C and, after plasma processing, for 4h in the auto-sampler maintained on ice (recovery >85%)...
October 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28985718/gender-differences-in-the-prevalence-of-congenital-heart-disease-in-down-s-syndrome-a-brief-meta-analysis
#19
Tereza Cristina Pinheiro Diogenes, Felipe Alves Mourato, José Luiz de Lima Filho, Sandra da Silva Mattos
BACKGROUND: Down's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients...
October 6, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28976229/associations-of-atopy-and-asthma-during-aging-of-an-adult-population-over-a-20-year-follow-up
#20
Diogenes S Ferreira, Sonia Kaushik, Catherine L Smith, Shyamali C Dharmage, Geza P Benke, Bruce R Thompson, E Haydn Walters, Rory Wolfe, Michael J Abramson
OBJECTIVE: Atopy is associated with asthma, but cross-sectional studies suggest this association may be weaker in older adults. It remains unclear if atopy predicts asthma later in adult life. We aimed to investigate whether atopy in young adults predicted asthma 20 years later and to quantify the contemporaneous relationship of atopy and asthma as adults age. METHODS: Participants of the European Community Respiratory Health Survey (ECRHS) in Melbourne aged 20-44 years were followed for 20 years and completed questionnaires, skin prick tests (SPT) and allergen specific immunoglobulin E measurement at a baseline and two subsequent surveys...
October 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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