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"Clostridium difficile" "proton pump inhibitor"

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https://www.readbyqxmd.com/read/28089100/community-onset-clostridium-difficile-infection-at-a-tertiary-medical-center-in-southern-taiwan-2007-2015
#1
Chin-Shiang Tsai, Yuan-Pin Hung, Jen-Chieh Lee, Nan-Yao Lee, Po-Lin Chen, Ling-Shan Syue, Ming-Chi Li, Chia-Wen Li, Wen-Chien Ko
BACKGROUND: Clostridium difficile infection (CDI) is well-known as the major cause of infectious diarrhea in hospitalized patients. Community-onset CDI (CO-CDI) is an emerging threat. However, clinical information of CO-CDI in Taiwan remains scarce. METHODS: A retrospective study was conducted at a medical center in southern Taiwan. Symptomatic patients between 2007 and 2015 with C. difficile toxin or tcdB detected in stool were identified as CDI, and were classified as CO-CDI [including community-associated CDI (CA-CDI) and community-onset health care facility-associated CDI (CO-HCFA-CDI)] and health care facility-onset CDI (HCFO-CDI)...
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28075419/surveillance-of-clostridium-difficile-infections-results-from-a-six-year-retrospective-study-in-nine-hospitals-of-a-north-italian-local-health-authority
#2
Greta Roncarati, Laura Dallolio, Erica Leoni, Manuela Panico, Angela Zanni, Patrizia Farruggia
Clostridium difficile is an emerging cause of healthcare associated infections. In nine hospitals of an Italian Local Health Authority the episodes of C. difficile infection (CDI) were identified using the data registered by the centralized Laboratory Information System, from 2010 to 2015. CDI incidence (positive patients for A and/or B toxins per patients-days) was analysed per year, hospital, and ward. A number of cases approximately equivalent to the mean of identified cases per year were studied retrospectively to highlight the risk factors associated to CDI and their severity...
January 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28054368/acid-suppression-medications-and-bacterial-gastroenteritis-a-population-based-cohort-study
#3
Li Wei, Lasantha Ratnayake, Gabby Phillips, Chris C McGuigan, Steve V Morant, Robert W Flynn, Isla S Mackenzie, Thomas M MacDonald
AIMS: To investigate whether acid suppression medicines (ASMs) increase the risk of bacterial gastroenteritis. METHODS: A population-based, propensity-score matched cohort study using a record-linkage database in Tayside, Scotland. The study consisted of 188,323 exposed to ASMs [proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RA)] and 376,646 controls (a propensity-score matched cohort from the rest of population who were not exposed to ASMs) between 1999 and 2013...
January 5, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28052855/syn-004-ribaxamase-an-oral-%C3%AE-lactamase-designed-to-protect-the-gut-microbiome-from-the-deleterious-effects-of-certain-intravenously-administered-%C3%AE-lactam-antibiotics-degrades-ceftriaxone-excreted-into-the-intestine-in-phase-2a-clinical-studies
#4
John F Kokai-Kun, Tracey Roberts, Olivia Coughlin, Eric Sicard, Marianne Rufiange, Richard Fedorak, Christian Carter, Marijke H Adams, James Longstreth, Heidi Whalen, Joseph Sliman
SYN-004 (ribaxamase) is a β-lactamase designed to be orally administered concurrently with intravenous β-lactam antibiotics including most penicillins and cephalosporins. Ribaxamase's anticipated mechanism of action is to degrade excess β-lactam antibiotic that is excreted into the small intestine. This enzymatic inactivation of excreted antibiotic is expected to protect the gut microbiome from disruption and thus prevent undesirable side effects including secondary infections like Clostridium difficile as well as other antibiotic-associated diarrheas...
January 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27920416/re-evaluating-the-inhibition-of-stress-erosions-revise-a-protocol-for-pilot-randomized-controlled-trial
#5
Waleed Alhazzani, Gordon Guyatt, John C Marshall, Richard Hall, John Muscedere, Francois Lauzier, Lehana Thabane, Mohammed Alshahrani, Shane W English, Yaseen M Arabi, Adam M Deane, Tim Karachi, Bram Rochwerg, Simon Finfer, Nick Daneman, Nicole Zytaruk, Diane Heel-Ansdell, Deborah Cook, On Behalf Of
INTRODUCTION: Clinicians routinely administer stress ulcer prophylaxis to mechanically ventilated patients in the intensive care unit (ICU), most commonly prescribing proton pump inhibitors (PPIs). However, the incidence of gastrointestinal (GI) bleeding from stress ulceration is low and recent observational studies suggest these agents may increase infections. Therefore, a large randomized clinical trial (RCT) is needed to inform modern practice. The aim of this multicenter pilot trial is to determine the feasibility of performing a large RCT to investigate the efficacy and safety of withholding intravenous pantoprazole...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27825595/effect-of-a-national-4c-antibiotic-stewardship-intervention-on-the-clinical-and-molecular-epidemiology-of-clostridium-difficile-infections-in-a-region-of-scotland-a-non-linear-time-series-analysis
#6
Timothy Lawes, José-María Lopez-Lozano, Cesar A Nebot, Gillian Macartney, Rashmi Subbarao-Sharma, Karen D Wares, Carolyn Sinclair, Ian M Gould
BACKGROUND: Whereas many antibiotics increase risk of Clostridium difficile infection through dysbiosis, epidemic C difficile ribotypes characterised by multidrug resistance might depend on antibiotic selection pressures arising from population use of specific drugs. We examined the effect of a national antibiotic stewardship intervention limiting the use of 4C antibiotics (fluoroquinolones, clindamycin, co-amoxiclav, and cephalosporins) and other infection prevention and control strategies on the clinical and molecular epidemiology of C difficile infections in northeast Scotland...
November 4, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27823794/clostridium-difficile-associated-diarrhoea-an-increased-problem
#7
Leticia Urbina Soto, Sara García Ávila, Ana Isabel Córdoba Alonso, M Pía Roiz Mesones, Ana M Arnaiz García, M Carmen Valero Díaz de Lamadrid
INTRODUCTION: Clostridium difficile associated diarrhoea is a major health problem that seems to be on the increase. In our study, we analyse the changes in the incidence of this infection over the last 11 years. METHODS: A descriptive study in hospitalised patients with Clostridium difficile associated diarrhoea in University Hospital Marqués de Valdecilla (Santander, Spain) from 2004 to 2014. RESULTS: A total of 244 adults were identified [53% men; 66 (SD 15) years]...
December 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27809338/cost-effectiveness-of-histamine2-receptor-antagonists-versus-proton-pump-inhibitors-for-stress-ulcer-prophylaxis-in-critically-ill-patients
#8
Drayton A Hammond, Niranjan Kathe, Anuj Shah, Bradley C Martin
STUDY OBJECTIVE: To determine the cost-effectiveness of stress ulcer prophylaxis with histamine2 receptor antagonists (H2RAs) versus proton pump inhibitors (PPIs) in critically ill and mechanically ventilated adults. DESIGN: A decision analytic model estimating the costs and effectiveness of stress ulcer prophylaxis (with H2RAs and PPIs) from a health care institutional perspective. PATIENTS: Adult mixed intensive care unit (ICU) population who received an H2RA or PPI for up to 9 days...
January 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/27804875/clostridium-difficile-infection-associations-with-chemotherapy-radiation-therapy-and-targeting-therapy-treatments
#9
Avi Peretz, Izhar Ben Shlomo, Orna Nitzan, Luigi Bonavina, Pmela M Schaffer, Moshe Schaffer
BACKGROUND: Although mucositis, diarrhea, and constipation as well as immunosuppression are well recognized side-effects of cancer treatment, the underlying mechanisms including changes in the composition of gut microbiota and Clostridium difficile infection have not yet been thoroughly reviewed. OBJECTIVE: We herein set out to review the literature regarding the relations between cancer chemotherapy, radiation treatment, and Clostridium difficile-associated colitis...
October 28, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27788814/identification-of-risk-factors-associated-with-clostridium-difficile-infection-in-liver-transplantation-recipients-a-single-center-analysis
#10
B G Rogala, G E Malat, D H Lee, M N Harhay, A M Doyle, T E Bias
Clostridium difficile remains the leading cause of health care-associated infectious diarrhea, and its incidence and severity are increasing in liver transplant recipients. Several known risk factors for C difficile infection (CDI) are inherently associated with liver transplantation, such as severe underlying illness, immunosuppression, abdominal surgery, and broad-spectrum antibiotic use. We conducted a single-center retrospective case control study to characterize risk factors for CDI among patients who received a liver transplant from January 2008 to December 2012...
October 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27785569/-clostridium-difficile-infections-in-geriatric-patients
#11
R Simmerlein, A Basta, M Gosch
Clostridium difficile is the main cause of nosocomial antibiotic-associated diarrhea in adults in Europe and North America. Infections with C. difficile typically occur in elderly patients with comorbidities and prior antibiotic therapy. Other risk factors are proton pump inhibitors, which are taken by many elderly patients. The main virulence factors are toxins A and B. The clinical spectrum ranges from asymptomatic colonization to severe disease with abdominal complications and sepsis. The current diagnostic gold standard is anaerobic culture but is impractical in routine use due to the long duration...
December 2016: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/27677811/assessing-the-risk-of-hospital-acquired-clostridium-difficile-infection-with-proton-pump-inhibitor-use-a-meta-analysis
#12
Vanessa Arriola, Jessica Tischendorf, Jackson Musuuza, Anna Barker, Jeffrey W Rozelle, Nasia Safdar
BACKGROUND Clostridium difficile is the principal infectious cause of antibiotic-associated diarrhea and accounts for 12% of hospital-acquired infections. Recent literature has shown an increased risk of C. difficile infection (CDI) with proton pump inhibitor (PPI) use. OBJECTIVE To conduct a systematic assessment of the risk of hospital-acquired CDI following exposure to PPI. METHODS We searched multiple databases for studies examining the relationship between PPI and hospital-acquired CDI. Pooled odds ratios were generated and assessment for heterogeneity performed...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27650918/a-comparison-of-histamine-receptor-antagonists-versus-proton-pump-inhibitor-gastrointestinal-ulcer-prophylaxis-in-kidney-transplant-recipients
#13
Ginger E Rouse, Karen Hardinger, Demetra Tsapepas, Eric M Tichy
INTRODUCTION: There are several different agents that can be used for gastrointestinal (GI) ulcer prophylaxis in posttransplant recipients, such as histamine-2 receptor antagonists (H2RA) or proton pump inhibitors (PPIs). RESEARCH QUESTION: This study was conducted to compare the incidence of adverse kidney events in transplant recipients who received prophylaxis with H2RAs or PPIs. DESIGN: This retrospective study included all kidney transplant recipients from 3 transplant centers who were transplanted in 2009 through 2011...
September 20, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27645304/proton-pump-inhibitors-and-risk-of-clostridium-difficile-infection-a-multi-country-study-using-sequence-symmetry-analysis
#14
Elizabeth E Roughead, Esther W Chan, Nam-Kyong Choi, Jenna Griffiths, Xue-Mei Jin, Joongyub Lee, Michio Kimura, Tomomi Kimura, Kiyoshi Kubota, Edward Chia-Cheng Lai, Kenneth Kc Man, Tuan Anh Nguyen, Nobuhiro Ooba, Byung-Joo Park, Tsugumichi Sato, Ju-Young Shin, TongTong Wang, Ian Ck Wong, Yea-Huei Kao Yang, Nicole L Pratt
OBJECTIVE: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27582058/a-quantitative-analysis-of-fda-adverse-event-reports-with-oral-bisphosphonates-and-clostridium-difficile
#15
Kevin W McConeghy, Melinda M Soriano, Larry H Danziger
BACKGROUND: Studies have shown associations between Clostridium difficile infection (CDI) and non-antimicrobial medications including proton pump inhibitors, osteoporosis medications, and antidepressants. OBJECTIVES: Our primary objective was to evaluate oral bisphosphonates and reported CDI adverse drug reactions in the United States using the Food and Drug Administration Adverse Event Reporting System data (FAERS). METHODS: We performed a disproportionality analysis evaluating the proportion of reports with bisphosphonates and CDI compared with other adverse drug reactions in the database...
October 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27575714/proton-pump-inhibitors-do-not-increase-risk-for-clostridium-difficile-infection-in-the-intensive-care-unit
#16
David M Faleck, Hojjat Salmasian, E Yoko Furuya, Elaine L Larson, Julian A Abrams, Daniel E Freedberg
OBJECTIVES: Patients in the intensive care unit (ICU) frequently receive proton pump inhibitors (PPIs) and have high rates of Clostridium difficile infection (CDI). PPIs have been associated with CDI in hospitalized patients, but ICU patients differ fundamentally from non-ICU patients and few studies have focused on PPI use exclusively in the critical care setting. We performed a retrospective cohort study to determine the associations between PPIs and health-care facility-onset CDI in the ICU...
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27543598/impact-of-a-pharmacist-driven-protocol-to-decrease-proton-pump-inhibitor-use-in-non-intensive-care-hospitalized-adults
#17
Jessica Michal, Thomas Henry, Connie Street
PURPOSE: Results of a pharmacist-driven protocol to decrease proton pump inhibitor (PPI) use in non-intensive care unit (ICU) hospitalized adults are presented. METHODS: This concurrent preintervention and postintervention study included subjects at least 18 years of age receiving PPIs while hospitalized in general medical or surgical beds. Patients were identified for inclusion in the postintervention group using a daily list of hospitalized patients with active PPI orders...
September 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27455386/risk-and-severity-of-hospital-acquired-clostridium-difficile-infection-in-patients-taking-proton-pump-inhibitors
#18
Paul O Lewis, John M Litchfield, Jennifer L Tharp, Rebecca M Garcia, Mohsen Pourmorteza, Chakradhar M Reddy
STUDY OBJECTIVE: To compare the rates and severity of hospital-acquired Clostridium difficile infection (CDI) among patients taking proton pump inhibitors (PPIs) versus those not taking PPIs. DESIGN: Retrospective, single-center, cohort study. SETTING: Tertiary community hospital with a teaching service. PATIENTS: A total of 41,663 patients with CDI who were hospitalized between January 2013 and May 2014; of those, 17,471 patients (41...
September 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27449956/reducing-co-administration-of-proton-pump-inhibitors-and-antibiotics-using-a-computerized-order-entry-alert-and-prospective-audit-and-feedback
#19
Christopher E Kandel, Suzanne Gill, Janine McCready, John Matelski, Jeff E Powis
BACKGROUND: Antibiotics and proton pump inhibitors (PPIs) are associated with Clostridium difficile infection (CDI). Both a computer order entry alert to highlight this association as well as antimicrobial stewardship directed prospective audit and feedback represent novel interventions to reduce the co-administration of antibiotics and PPIs among hospitalized patients. METHODS: Consecutive patients admitted to two General Internal Medicine wards from October 1, 2010 until March 31, 2013 at a teaching hospital in Toronto, Ontario, Canada were evaluated...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27377737/proton-pump-inhibitors-should-be-used-with-caution-in-critically-ill-patients-to-prevent-the-risk-of-clostridium-difficile-infection
#20
EDITORIAL
Jung Hwa Min, You Sun Kim
No abstract text is available yet for this article.
July 15, 2016: Gut and Liver
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