keyword
https://read.qxmd.com/read/38512381/severe-rhabdomyolysis-after-exertional-heat-stroke-treated-with-a-hemoadsorber-cytosorb-lesson-for-the-clinical-nephrologist-%C3%A2
#1
JOURNAL ARTICLE
Marijana Mikacic, Tanja Ilic Begovic, Ivan Jerkovic, Marina Maras Batinic, Vedran Kovacic
No abstract text is available yet for this article.
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38374857/recurrent-rhabdomyolysis-induced-by-a-viral-illness-in-a-young-patient
#2
Zahid Khan, Osman Ahmed, Syed Aun Muhammad, Jonard Carpio
Rhabdomyolysis is a syndrome caused by skeletal muscle disruption that results in the release of muscle proteins into circulation, which can lead to life-threatening systemic complications. These complications include acute kidney injury (AKI), renal failure, compartment syndrome, and disseminated intravascular coagulopathy. Patients commonly present with muscle pain, fatigue, weakness, and dark-colored urine. We present the case of a 37-year-old male who presented to the hospital with pain in the lower limbs and difficulty in mobility for the past two days after returning from Jamaica...
January 2024: Curēus
https://read.qxmd.com/read/38315431/low-complex-i-and-iii-activity-derived-myopathy-causing-recurrent-exertional-rhabdomyolysis
#3
JOURNAL ARTICLE
Yao-Wen Eliot Hu
No abstract text is available yet for this article.
February 1, 2024: Current Sports Medicine Reports
https://read.qxmd.com/read/38261548/fatal-case-of-exercise-collapse-associated-with-sickle-cell-trait-with-novel-underlying-lama2-mutation
#4
JOURNAL ARTICLE
Couger Jimenez Jaramillo, Thomas Gibbons, Rachel Rose, John Walsh
Sickle cell trait is typically thought to be an asymptomatic carrier state, but it is rarely associated with exertional rhabdomyolysis in cases termed Exercise Collapse Associated with Sickle Cell Trait (ECAST). In a subset of these cases, underlying disease contributes to the development and/or severity of the ensuing medical complications. We describe the first ever case of ECAST reported in a previously asymptomatic, multiply deployed, highly physically active service member with an underlying heterozygous LAMA2 mutation...
January 23, 2024: American Journal of Forensic Medicine and Pathology
https://read.qxmd.com/read/38188547/serum-procalcitonin-levels-are-associated-with-rhabdomyolysis-following-exertional-heatstroke-an-over-10-year-intensive-care-survey
#5
JOURNAL ARTICLE
Li Zhong, Feifei Shuai, Conglin Wang, Lipeng Han, Zhifeng Liu, Ming Wu
BACKGROUND: Heatstroke has become a common emergency event in hospitals. Procalcitonin (PCT) is used as a biomarker of infection in the emergency department (ED), but its role in rhabdomyolysis (RM) following exertional heatstroke (EHS) remains unclear. METHODS: A retrospective cohort study enrolled patients with EHS from the intensive care unit (ICU). We collected RM biomarkers, inflammation markers, critical disease scores at admission, 24 h, 48 h, and discharge, and 90-day mortality...
2024: World Journal of Emergency Medicine
https://read.qxmd.com/read/37919499/modulation-of-inflammatory-oxidative-and-apoptotic-stresses-mediates-the-renoprotective-effect-of-daidzein-against-glycerol-induced-acute-kidney-injury-in-rats
#6
JOURNAL ARTICLE
Rami B Kassab, Ahmed A Elhenawy, AbdulrahmanTheyab, Yousef M Hawsawi, Osama M Al-Amer, Atif Abdulwahab A Oyouni, Ola A Habotta, Hussam A Althagafi, Fahad Alharthi, Maha S Lokman, Khalaf F Alsharif, Ashraf Albrakati, Ali O Al-Ghamdy, Ehab Kotb Elmahallawy, Mohamed A Elhefny, Kalid E Hassan, Alaa Jameel A Albarakati, Ahmed E Abdel Moneim, Ahmed A Moustafa
Acute kidney injury (AKI) is a life-threatening complication that accompanies rhabdomyolysis. Daidzein is a dietary isoflavone that has various biological activities. This study examined the therapeutic potential of daidzein and the underlying mechanisms against AKI induced by glycerol in male rats. Animals were injected once with glycerol (50%, 10 ml/kg, intramuscular) for induction of AKI and pre-treated orally with daidzein (25, 50, and 100 mg/kg) for 2 weeks. Biochemical, histopathological, immunohistopathological, and molecular parameters were assessed to evaluate the effect of daidzein...
November 3, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/37900084/protective-effect-of-citronellol-in-rhabdomyolysis-induced-acute-kidney-injury-in-mice
#7
JOURNAL ARTICLE
Yasameen Shakir Mahmood, Sarmed Hashim Kathem
Acute kidney injury (AKI) is a serious pathophysiological event consequent to rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene in essential oils of aromatic plant species. In this study, we explored the protective effects of citronellol on AKI resulting from glycerol-induced rhabdomyolysis. Rhabdomyolysis was induced by a single intramuscular injection of glycerol 50% (10mg/kg) in the thigh caudal muscle...
July 2023: Journal of Medicine and Life
https://read.qxmd.com/read/37816654/immunogenicity-and-immunoprotection-of-the-functional-tl-hn-fragment-derived-from-tetanus-toxin
#8
JOURNAL ARTICLE
Xu-Yang Liu, Dong-Kui Wei, Zhi-Ying Li, Jian-Sheng Lu, Xin-Mei Xie, Yun-Zhou Yu, Xiao-Bin Pang
Tetanus toxin (TeNT) is a protein toxin produced by Clostridium tetani bacteria, which causes hyperreflexia and rhabdomyolysis by spastic paralysis. Like botulinum neurotoxin, TeNT comprises a heavy chain (HC) and a light chain (LC) linked via an interchain disulfide bond, which include the following three functional domains: a receptor-binding domain (Hc), a translocation domain (HN), and a catalytic domain (LC). Herein, we produced and characterized three functional domains of TeNT and three types of TeNT-derived L-HN fragments (TL-HN, TL-GS-HN and TL-2A-HN), which contained L and HN domains but lacked the Hc domain...
October 8, 2023: Vaccine
https://read.qxmd.com/read/37781817/oral-dantrolene-reduces-myalgia-and-hyperckemia-in-a-child-with-ryr1-related-exertional-myalgia-rhabdomyolysis
#9
JOURNAL ARTICLE
Elis Vanessa de Lima Silva, Karina Carvalho Donis, Fabiana Rita Camara Machado, Leonardo Simão Medeiros, Carlos Alberto de Moura Aschoff, Carolina Fischinger Moura de Souza, Fabiano de Oliveira Poswar, Jonas Alex Morales Saute
RYR1-related exertional myalgia/rhabdomyolysis (ERM) is an underrecognized condition, which can cause limiting muscle symptoms, and may account for more than one-third of undiagnosed rhabdomyolysis cases. Dantrolene has shown promising results in controlling muscle symptoms in individuals with ERM, however, its use in children remains poorly documented. This case report presents the successful treatment of a 5-year-old patient with ERM using oral dantrolene. The patient experienced notable improvements, including a reduction in the frequency and intensity of myalgia episodes, no hospitalizations due to rhabdomyolysis, a substantial decrease in creatine phosphokinase (CPK) levels, and enhanced performance on the 6-minute walk test...
2023: Journal of Neuromuscular Diseases
https://read.qxmd.com/read/37771523/a-systematic-review-on-outcomes-of-patients-with-heatstroke-and-heat-exhaustion
#10
JOURNAL ARTICLE
Hassan Adnan Bukhari
INTRODUCTION: Heatstroke (HS) is a severe form of heat-related illness (HRI) associated with high morbidity and mortality, representing a condition that includes long-term multiorgan dysfunction and susceptibility to further heat illness. METHODS: In a systematic review searching Medline PubMed from the studies conducted between 2009 and 2020, 16 papers were identified. RESULTS: A hallmark symptom of heat stroke is CNS dysfunction (a hallmark sign of HS) which manifests as mental status changes, including agitation, delirium, epilepsy, or coma at the time of the collapse...
2023: Open Access Emergency Medicine: OAEM
https://read.qxmd.com/read/37730012/covid-19-associated-rhabdomyolysis-a-scoping-review
#11
REVIEW
Anna Preger, Rebecca Wei, Brinton Berg, Beatrice A Golomb
BACKGROUND: SARS-CoV-2 infection ("Covid-19") and the hypoxemia that has attended some cases, may predispose to rhabdomyolysis. We sought to identify reported cases of Covid-19-associated rhabdomyolysis, examining concurrent risk factors (RFs) and mortality outcomes. METHODS & MATERIALS: We searched PubMed for articles conveying individual-level information on Covid-19-associated rhabdomyolysis, published between January 2020 and July 2022, with an English language abstract...
September 18, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/37701325/diagnosis-and-management-of-children-with-mcardle-syndrome-gsd-v-in-new-south-wales
#12
Louisa Adams, Arthavan Selvanathan, Kiera J Batten, Nancy van Doorn, Susan Thompson, Ashleigh Mitchell, Hugo Sampaio, Troy Dalkeith, Jacqui Russell, Carolyn J Ellaway, Michelle Farrar, Carolyn Broderick, Kaustuv Bhattacharya
Glycogen storage type V (GSD V-McArdle Syndrome) is a rare neuromuscular disorder characterised by severe pain early after the onset of physical activity. A recent series indicated a diagnostic delay of 29 years; hence reports of children affected by the disorder are uncommon (Lucia et al., 2021, Neuromuscul Disord , 31, 1296-1310). This paper presents eight patients with a median onset age of 5.5 years and diagnosis of 9.5 years. Six patients had episodes of rhabdomyolysis with creatine kinase elevations >50 000 IU/L...
September 2023: JIMD Reports
https://read.qxmd.com/read/37651584/first-case-of%C3%A2-surgically-treated-chronic-exertional-compartment-syndrome-of%C3%A2-the-arm
#13
JOURNAL ARTICLE
Emilie Bilichtin, Camille Choufani, Clément Derkenne, Clotilde Vioujard, Romain Pacull
This paper reports the first case of chronic exertional compartment syndrome in the arm treated surgically. The diagnosis was made in a patient who is under 30 years old, military, and very athletic, with recurrent exertional pain in the anterior compartment of the arms associated with rhabdomyolysis. The high-pressure measurements in the arms' anterior compartment after exertional exercise confirmed the diagnosis. Given the patient's functional demands, a surgical treatment of fasciotomy of the anterior compartment by miniapproach was performed and allowed the resolution of symptomatology with a return to sport at the same level after 3 months...
August 30, 2023: Military Medicine
https://read.qxmd.com/read/37627359/associations-between-medical-disorders-and-racing-outcomes-in-poorly-performing-standardbred-trotter-racehorses-a-retrospective-study
#14
JOURNAL ARTICLE
Chiara Maria Lo Feudo, Luca Stucchi, Giovanni Stancari, Bianca Conturba, Chiara Bozzola, Enrica Zucca, Francesco Ferrucci
Poor performance in racehorses is commonly associated with subclinical diseases. This study aims to evaluate the associations between medical disorders and racing results in Standardbred trotters. The clinical records of 248 poorly performing Standardbreds were retrospectively reviewed, and their racing results were extracted from an online database, concerning the periods 3 months before and 6 months after hospitalization and the entire lifetime. Generalized linear models were used to evaluate the effects of different disorders on racing outcomes...
August 9, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37534888/acute-renal-failure-with-severe-loin-pain-and%C3%A2-patchy-renal-ischemia-after-anaerobic-exercise-in%C3%A2-active-duty-marines
#15
JOURNAL ARTICLE
Kathryn G Hughes, Nancy L Miller
Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise (ALPE) is a rare cause of exertional acute kidney injury. The proposed mechanism of injury in ALPE is renovascular spasm, in the setting of oxidative stress and muscular damage, which creates a characteristic wedge-shaped infarction pattern on delayed imaging. Patients present with nausea, vomiting, loin or abdominal pain, and fatigue within 1-2 days of anaerobic exercise, associated with an acute rise in serum creatinine, which generally plateaus within 3 days...
August 3, 2023: Military Medicine
https://read.qxmd.com/read/37418508/exertional-rhabdomyolysis-among-active-component-members-of-the-u-s-armed-forces-2018-2022
#16
JOURNAL ARTICLE
(no author information available yet)
Exertional rhabdomyolysis is a pathologic muscle breakdown associated with strenuous physical activity. A largely preventable condition, it persists as an occupational hazard of military training and operations, especially in high heat environments among individuals exerting themselves to endurance limits. During the 5-year surveillance period, unadjusted incidence rates of exertional rhabdomyolysis among U.S. service members declined by approximately 15%, from 43.1 cases per 100,000 person-years (p-yrs) in 2018 to 36...
April 20, 2023: MSMR
https://read.qxmd.com/read/37408574/serum-myoglobin-modulates-kidney-injury-via-inducing-ferroptosis-after-exertional-heatstroke
#17
JOURNAL ARTICLE
Yingyi Luan, Enping Huang, Jiajia Huang, Zhenjia Yang, Zhipeng Zhou, Yan Liu, Conglin Wang, Ming Wu
BACKGROUND AND OBJECTIVES: Myoglobin released by rhabdomyolysis (RM) is considered to be involved in pathogenesis of kidney disease caused by crush injury, but whether high level of serum myoglobin predisposes patients to acute kidney injury (AKI) and its molecular mechanisms are still unclear in exertional heatstroke (EHS). We aimed to determine the association and potential mechanism of myoglobin and AKI, and further investigate the targeted therapeutic agents for myoglobinemia. METHODS: Serum myoglobin concentrations in patients with EHS were measured at admission, 24 h and 48 h after admission and discharge...
July 2023: Journal of Translational Internal Medicine
https://read.qxmd.com/read/37404675/postmortem-diagnosis-of-very-long-chain-acyl-coa-dehydrogenase-vlcad-deficiency-in-a-neonate-with-sudden-cardiac-death
#18
Prapti Singh, Deirdre Amaro, Olugbemisola Obi, Fnu Kiran, Erin Hediger, Tomi L Toler, Patricia I Dickson, Dorothy K Grange
Very long chain acyl-CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive long chain fatty acid β-oxidation disorder with a variable clinical spectrum, ranging from an acute neonatal presentation with cardiac and hepatic failure to childhood or adult onset of symptoms with hepatomegaly or rhabdomyolysis provoked by illness or exertion. Neonatal cardiac arrest or sudden unexpected death can be the presenting phenotype in some patients, emphasizing the importance of early clinical suspicion and intervention...
July 2023: JIMD Reports
https://read.qxmd.com/read/37334257/systemic-capillary-leak-syndrome-with-cerebral-involvement-in-a-c9orf72-expansion-carrier-case-report-and-review-of-the-literature
#19
JOURNAL ARTICLE
Stefan Sennfält, Oskar Aspegren, Martin Engvall, Tobias Granberg, Fredrik Piehl
OBJECTIVE: Systemic capillary leak syndrome (SCLS) is a rare condition associated with episodes of hypotension, hemoconcentration, hypoalbuminemia, and rhabdomyolysis. We describe a middle-aged man presenting with several distinct SCLS-like episodes, the last being fatal. In addition, in the year before the final event, he developed rapid cognitive decline with contrast-enhancing lesions on MRI and highly elevated neurofilament light protein levels in CSF. METHODS: Data and imaging were obtained from patient medical records...
August 2023: Neurology. Genetics
https://read.qxmd.com/read/37319304/acute-exertional-bilateral-thigh-compartment-syndrome-in-a-patient-with-rhabdomyolysis-after-spin-class-a-case-report
#20
JOURNAL ARTICLE
Jomar N A Aryee, Jeremy M Silver, Jamie Grossman, David Polonet, Patrick S Buckley
CASE: A healthy 24-year-old woman developed rhabdomyolysis and acute bilateral thigh compartment syndrome after 10 minutes of spin class. She was successfully managed with early recognition, aggressive fluid resuscitation, and prompt bilateral surgical decompressive fasciotomy. CONCLUSION: Rhabdomyolysis with acute compartment syndrome is a rare but devastating combination of conditions. A high suspicion for rhabdomyolysis and progression to acute compartment syndrome is warranted for any patient presenting with increasing pain even with a limited history of trauma or exertion...
April 1, 2023: JBJS Case Connector
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