Rami B Kassab, Ahmed A Elhenawy, AbdulrahmanTheyab, Yousef M Hawsawi, Osama M Al-Amer, Atif Abdulwahab A Oyouni, Ola A Habotta, Hussam A Althagafi, Fahad Alharthi, Maha S Lokman, Khalaf F Alsharif, Ashraf Albrakati, Ali O Al-Ghamdy, Ehab Kotb Elmahallawy, Mohamed A Elhefny, Kalid E Hassan, Alaa Jameel A Albarakati, Ahmed E Abdel Moneim, Ahmed A Moustafa
Acute kidney injury (AKI) is a life-threatening complication that accompanies rhabdomyolysis. Daidzein is a dietary isoflavone that has various biological activities. This study examined the therapeutic potential of daidzein and the underlying mechanisms against AKI induced by glycerol in male rats. Animals were injected once with glycerol (50%, 10 ml/kg, intramuscular) for induction of AKI and pre-treated orally with daidzein (25, 50, and 100 mg/kg) for 2 weeks. Biochemical, histopathological, immunohistopathological, and molecular parameters were assessed to evaluate the effect of daidzein...
November 3, 2023: Environmental Science and Pollution Research International