keyword
https://read.qxmd.com/read/38401874/poly-vinyl-alcohol-alginate-nanofibrous-mats-containing-malva-sylvestris-extract-synthesis-characterization-in-vitro-and-in-vivo-assessments-for-burn-wound-applications
#21
JOURNAL ARTICLE
Ali Akbarpour, Mostafa Rahimnejad, Mona Sadeghi-Aghbash, Farideh Feizi
An important part of wound healing is providing effective wound care, coupled with preventing wound infection, which slows or disrupts healing. There are currently many herbal plants that have historical supernatural properties that show remarkable wound healing abilities. These herbal extracts have shown promising results when applied to electrospun nanofibrous mats platforms for wound healing. Accordingly, Malva Sylvestris extract (MS) was electrospun into polyvinyl alcohol/alginate nanofibrous mats (PVA/ALG)...
February 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38397879/evaluating-the-healing-potential-of-j-plasma-scalpel-created-surgical-incisions-in-porcine-and-rat-models
#22
JOURNAL ARTICLE
Lilith Elmore, Nicholas J Minissale, Lauren Israel, Zoe Katz, Jordan Safran, Adriana Barba, Luke Austin, Thomas P Schaer, Theresa A Freeman
Cold atmospheric plasma devices generate reactive oxygen and nitrogen species that can be anti-microbial but also promote cell migration, differentiation, and tissue wound healing. This report investigates the healing of surgical incisions created using cold plasma generated by the J-Plasma scalpel (Precise Open handpiece, Apyx Medical, Inc.) compared to a steel scalpel in in vivo porcine and rat models. The J-Plasma scalpel is currently FDA approved for the delivery of helium plasma to cut, coagulate, and ablate soft tissue during surgical procedures...
January 25, 2024: Biomedicines
https://read.qxmd.com/read/38396201/self-implantable-core-shell-microneedle-patch-for-long-acting-treatment-of-keratitis-via-programmed-drug-release
#23
JOURNAL ARTICLE
Xue Jiang, Yinli Jin, Yongnian Zeng, Peng Shi, Wei Li
Bacteria-induced keratitis is a major cause of corneal blindness in both developed and developing countries. Instillation of antibiotic eyedrops is the most common management of bacterial keratitis but usually suffers from low bioavailability (i.e., <5%) and frequent administration, due to the existence of corneal epithelial barrier that prevents large and hydrophilic drug molecules from entering the cornea, and the tear film on corneal surface that rapidly washes drug away from the cornea. Here, a self-implantable core-shell microneedle (MN) patch with programmed drug release property to facilitate bacterial keratitis treatment is reported...
February 23, 2024: Small
https://read.qxmd.com/read/38395201/electro-acupuncture-inhibits-hdac2-via-modulating-gut-microbiota-to-ameliorate-sni-induced-pain-and-depression-like-behavior-in-rats
#24
JOURNAL ARTICLE
Sheng Li, Jianpeng Huang, Luo Ding, Wenbin Fu, Jianhua Liu
BACKGROUND: Depression and chronic pain frequent co-occur, exacerbating each other's symptoms and hindering treatment. Emerging studies have highlighted abnormal gut microbiota in both conditions. Previous studies have demonstrated the clinical effectiveness of electro-acupuncture (EA) in managing these conditions, yet the underlying mechanisms remain elusive. METHODS: Spared nerve injury (SNI) was employed to induce chronic pain and depression-like behavior. Rats were randomly assigned to sham SNI (SS), SNI, and EA groups...
February 21, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38393580/a-dual-therapeutic-approach-to-diabetes-mellitus-via-bioactive-phytochemicals-found-in-a-poly-herbal-extract-by-restoration-of-favorable-gut-flora-and-related-short-chain-fatty-acids
#25
JOURNAL ARTICLE
Amit Kumar Singh, Pradeep Kumar, Sunil Kumar Mishra, Vishnu D Rajput, Kavindra Nath Tiwari, Anand Kumar Singh, Tatiana Minkina, Ajay Kumar Pandey, Prabhat Upadhyay
Diabetes mellitus (DM), a metabolic and endocrine condition, poses a serious threat to human health and longevity. The emerging role of gut microbiome associated with bioactive compounds has recently created a new hope for DM treatment. UHPLC-HRMS methods were used to identify these compounds in a poly herbal ethanolic extract (PHE). The effects of PHE on body weight (BW), fasting blood glucose (FBG) level, gut microbiota, fecal short-chain fatty acids (SCFAs) production, and the correlation between DM-related indices and gut microbes, in rats were investigated...
February 23, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38391542/a-novel-antibiotic-rhodomyrtone-pharmacokinetic-studies-in-a-murine-model-and-optimization-and-validation-of-high-performance-liquid-chromatographic-method-for-plasma-analysis
#26
JOURNAL ARTICLE
Tan Suwandecha, Boon-Ek Yingyongnarongkul, Kanokkan Towtawin, Supayang Piyawan Voravuthikunchai, Somchai Sriwiriyajan
Rhodomyrtone has indisputable and undeniable potential as a new antibiotic for antibiotic-resistant Gram-positive bacteria. Therefore, the main objective of this study was to determine the pharmacokinetics profiles of orally administered rhodomyrtone in rats. A reverse-phase HPLC-UV method was developed, optimized and validated for the analysis of rhodomyrtone concentrations in rat plasma. The retention time of papaverine and rhodomyrtone was 3.928 and 5.937 min, with no interference with the excipients used...
February 5, 2024: Antibiotics
https://read.qxmd.com/read/38386624/evaluation-of-purine-nucleoside-degrading-ability-and-in-vivo-uric-acid-lowering-of-streptococcus-thermophilus-idcc-2201-a-novel-antiuricemia-strain
#27
JOURNAL ARTICLE
Dayoung Kim, Jin Seok Moon, Ji Eun Kim, Ye-Ji Jang, Han Sol Choi, Ikhoon Oh
This study evaluated 15 lactic acid bacteria with a focus on their ability to degrade inosine and hypo-xanthine-which are the intermediates in purine metabolism-for the management of hyperuricemia and gout. After a preliminary screening based on HPLC, Lactiplantibacillus plantarum CR1 and Lactiplantibacillus pentosus GZ1 were found to have the highest nucleoside degrading rates, and they were therefore selected for further characterization. S. thermophilus IDCC 2201, which possessed the hpt gene encoding hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and exhibited purine degradation, was also selected for further characterization...
2024: PloS One
https://read.qxmd.com/read/38383596/a-convergent-evolutionary-pathway-attenuating-cellulose-production-drives-enhanced-virulence-of-some-bacteria
#28
JOURNAL ARTICLE
Nguyen Thi Khanh Nhu, M Arifur Rahman, Kelvin G K Goh, Seung Jae Kim, Minh-Duy Phan, Kate M Peters, Laura Alvarez-Fraga, Steven J Hancock, Chitra Ravi, Timothy J Kidd, Matthew J Sullivan, Katharine M Irvine, Scott A Beatson, Matthew J Sweet, Adam D Irwin, Jana Vukovic, Glen C Ulett, Sumaira Z Hasnain, Mark A Schembri
Bacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent evolution. Extra-intestinal pathogenic Escherichia coli (ExPEC) belonging to sequence type 95 (ST95) represent a global clone frequently associated with severe human infections including acute pyelonephritis, sepsis, and neonatal meningitis. Here, we analysed a publicly available dataset of 613 ST95 genomes and identified a series of loss-of-function mutations that disrupt cellulose production or its modification in 55...
February 21, 2024: Nature Communications
https://read.qxmd.com/read/38379554/colon-targeting-in-rats-dogs-and-ibd-patients-with-species-independent-film-coatings
#29
JOURNAL ARTICLE
F Ferraro, L M Sonnleitner, C Neut, S Mahieux, J Verin, J Siepmann, F Siepmann
Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides are degraded by colonic enzymes (secreted by bacteria), triggering the onset of drug release at the target site. It has to be pointed out that the microbiota in rats, dogs and humans substantially differ. Thus, the performance of this type of colon targeting system observed in animals might not be predictive for patients...
June 2024: International journal of pharmaceutics: X
https://read.qxmd.com/read/38376837/the-occurrence-and-resistance-of-shigella-flexneri-cect4804-to-acid-stress-in-vitro-and-in-vivo
#30
JOURNAL ARTICLE
Ines Taieb, Ali Ellafi, Sonia Ben Younes, Anouar Feriani, Amina Bakhrouf, Ridha Elmzoughi, Juan Alfonso Ayala Serrano, Chedia Jabeur
The ability to maintain intra‑cellular pH is crucial for many microbes mainly the enterobacteria to survive in diverse environments, particularly those that undergo fluctuations in pH. In this context, the growth and survival of Shigella flexneri at different acid pH values were evaluated to explain the response strategies involved in the adaptation of S. flexneri CECT4804 in acid stress conditions. Furthermore, the capacity of this strain to produce slime on Congo Red Agar, biofilm formation on polystyrene plate and hydrophobicity are reported...
July 31, 2023: Veterinaria Italiana
https://read.qxmd.com/read/38372569/wearable-magnetoelectric-stimulation-for-chronic-wound-healing-by-electrospun-cofe-2-o-4-ctab-pvdf-dressings
#31
JOURNAL ARTICLE
Qi Ke, Xinyi Zhang, Yuan Yang, Qi Chen, Jianyu Su, Youhong Tang, Liming Fang
Magnetoelectric stimulation is a promising therapy for various disorders due to its high efficacy and safety. To explore its potential in chronic skin wound treatment, we developed a magnetoelectric dressing, CFO@CTAB/PVDF (CCP), by electrospinning cetyltrimethylammonium bromide-modified CoFe2 O4 (CFO) particles with polyvinylidene fluoride. Cetyltrimethylammonium bromide (CTAB) serves as a dispersion surfactant for CFO, with its quaternary ammonium cations imparting antibacterial and hydrophilic properties to the dressing...
February 19, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38368632/investigation-of-the-therapeutic-effect-of-hedan-tablets-on-high-fat-diet-induced-obesity-in-rats-by-gc-ms-technology-and-16s-ribosomal-rna-gene-sequencing
#32
JOURNAL ARTICLE
Xuan Pan, Yumeng Zhang, Yongyao Qiao, Qingying Cao, Liuxin Wei, Min Zhao
Obesity is a persistent metabolic condition resulting from the excessive accumulation or abnormal distribution of body fat. This study aimed to establish an experimental rat model of obesity. The efficacy of treating obesity with Hedan tablets (HDT) was assessed by monitoring changes in weight, blood lipid levels, analyzing inflammatory factors, evaluating organ indices, and observing liver tissue pathology. Furthermore, we utilized 16S ribosomal RNA gene sequencing technology to explore changes in intestinal flora...
February 18, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38363776/therapeutic-effect-of-sanhua-decoction-on-rats-with-middle-cerebral-artery-occlusion-and-the-associated-changes-in-gut-microbiota-and-short-chain-fatty-acids
#33
JOURNAL ARTICLE
Yiming Ni, Liangyin Cai, Xiaojun Gou, Wenjie Li, Mingmei Zhou, Ying Huang
Sanhua decoction (SHD), a traditional prescription, has long been used in treating ischemic stroke (IS). However, the therapeutic effect of SHD and the associated changes in gut microbiota and short-chain fatty acids (SCFAs) are uncertain. In this study, a rat model of IS was established by the middle cerebral artery occlusion (MCAO). By evaluating the cerebral infarct area and brain tissue pathology, it was found that SHD ameliorated IS-related symptoms in MCAO rats. Using 16S rRNA gene sequencing, we found that SHD reduced abnormally elevated Lactobacillus and opportunistic pathogens such as Desulfovibrio, but increased some beneficial bacteria that produce SCFAs, including Clostridia, Lachnospiraceae, Ruminococcaceae, and Coprococcus...
2024: PloS One
https://read.qxmd.com/read/38358639/adzuki-and-mung-bean-sprouts-enriched-with-probiotic-lactiplantibacillus-plantarum-299v-improve-body-mass-gain-and-antioxidant-status-and-reduce-the-undesirable-enzymatic-activity-of-microbiota-in-healthy-rats
#34
JOURNAL ARTICLE
Michał Świeca, Julita Reguła, Marta Molska, Piotr Jarocki, Jakub Murat, Monika Pytka, Joanna Wessely-Szponder
Introducing and establishing new food requires a detailed evaluation of its safety, nutritional value and functionality, thus the control and probiotic-rich adzuki and mung bean sprouts were studied in an in vivo rats model. However, the total feed intake did not differ significantly between the groups, the highest body weight gain and body weight change were recorded in the control AIN diet. At the same time, the addition of legume sprouts caused a reduction of these parameters (up to 25% in the variant with probiotic-rich adzuki bean sprouts)...
February 15, 2024: Plant Foods for Human Nutrition
https://read.qxmd.com/read/38356924/wet-environment-induced-adhesion-and-softening-of-coenzyme-based-polymer-elastic-patch-for-treating-periodontitis
#35
JOURNAL ARTICLE
Ying Qi, Chenyu Xu, Zhuodan Zhang, Qian Zhang, Ziyang Xu, Xinrui Zhao, Yanhong Zhao, Chunyan Cui, Wenguang Liu
Periodontitis, a common chronic inflammatory disease caused by pathogenic bacteria, can be treated with diverse biomaterials by loading drugs, cytokines or proteins. However, these biomaterials often show unsatisfactory therapeutic efficiency due to their poor adhesion, short residence time in the wet and dynamic oral cavity and emerging drug resistance. Here we report a wet-responsive methacrylated gelatin (GelMA)-stabilized co-enzyme polymer poly(α-lipoic acid) (PolyLA)-based elastic patch with water-induced adhesion and softening features...
May 2024: Bioactive Materials
https://read.qxmd.com/read/38352234/taurine-regulates-the-expression-of-interleukin-17-10-and-intestinal-flora-and-protects-the-liver-and-intestinal-mucosa-in-a-nonalcoholic-fatty-liver-disease-rat-model
#36
JOURNAL ARTICLE
Fu-Li Zhu, Ting Huang, Zi-Li Lv, Gang Liang, Zhen Yao, Lian-Cheng Lan, Abdul Qadir, Xiu-Qi Chen, Qing-Wen Shan
PURPOSE: To investigate the intestinal inflammatory response and the abundance of intestinal bacteria in rats with high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) and assess the intervention effects of taurine (TAU). METHODS: Forty male Sprague-Dawley rats were randomly divided into five groups: group I, normal diet and normal saline gavage; group II, normal diet and TAU gavage; group III, HFD and normal saline gavage; group IV, HFD and TAU gavage (from the 1st week); group V, HFD and TAU gavage (from the 10th week)...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38351762/infective-endocarditis-prevention-strategy-and-risk-factors-in-an-animal-model
#37
JOURNAL ARTICLE
Gergo Mitov, Roman Kilgenstein, Philipp Partenheimer, Serge Ricart, Dennis Ladage
Infective endocarditis is a serious infection of the endocardium, especially the heart valves, which is associated with a high mortality rate. It generally occurs in patients with altered and abnormal cardiac architecture combined with exposure to bacteria from trauma and other potentially high-risk activities with transient bacteremia.
October 31, 2023: Folia Medica
https://read.qxmd.com/read/38349437/gut-microbiota-disorders-in-obesity-associated-benign-prostatic-hyperplasia-in-rats
#38
JOURNAL ARTICLE
Lijiang Gu, Akehu Alemasi, Yuhang Chen, Xing Li, Yibo Mei, Jinlai Zhou, Dalin He, Jin Zeng
UNLABELLED: Benign prostatic hyperplasia (BPH), commonly seen in older men, can cause symptoms of discomfort, and may even need surgical intervention. Studies have shown the potential link between gut microbes and BPH, but the molecular association is not fully understood. METHODS: Four-week-old male Sprague-Dawley rats (n = 16) were randomly allocated to normal control diet (ND, 10% fat) and high-fat diet-induced BPH (HFD, 45% fat) groups. Metagenomic analysis was used to examine the abundance and discrepancies in gut microbiota within the two groups after 24 weeks of feeding...
February 13, 2024: Biochemical Genetics
https://read.qxmd.com/read/38348713/protective-effects-of-naringin-on-colistin-induced-damage-in-rat-testicular-tissue-modulating-the-levels-of-nrf-2-ho-1-akt-2-foxo1a-bax-bcl2-caspase-3-and-beclin-1-lc3a-lc3b-signaling-pathways
#39
JOURNAL ARTICLE
Nazım Abdülkadir Kankılıç, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Mustafa İleritürk, Sefa Küçükler, Serkan A Akarsu, Fatih M Kandemir
Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a natural flavonoid, has come to the fore as its antioxidant, anti-inflammatory, and antiapoptotic activities. The aim of the present study was to determine whether NRG has protective effects on COL-induced toxicity in testicular tissue. Thirty-five male Spraque rats were randomly divided into five groups (n = 7 per group): Control, COL, NRG, COL + NRG 50, COL + NRG 100...
February 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38348232/vitamin-d-improves-klebsiella-induced-severe-pneumonia-in-rats-by-regulating-intestinal-microbiota
#40
JOURNAL ARTICLE
Jia-Jia Hu, Yu-Sen Lin, Jing-Cong Zhang, Yan-Hong Wang
BACKGROUND: In the context of progressively uncontrolled drug resistance of bacteria, the difficulty of treating Klebsiella (KP)-induced pneumonia increases. Searching for drugs other than antibiotics has become an urgent task. Vitamin D (VD), meanwhile, is shown to be capable of treating pneumonia. Therefore, we aimed to explore the effects and mechanisms of VD on KP-infected rats. METHODS: Male Sprague Dawley rats were divided into the Control, VD, KP and KP+VD groups...
2024: Infection and Drug Resistance
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