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https://www.readbyqxmd.com/read/28092695/absorption-distribution-and-excretion-of-the-anti-tuberculosis-drug-delamanid-in-rats-extensive-tissue-distribution-suggests-potential-therapeutic-value-for-extrapulmonary-tuberculosis
#1
Masakazu Shibata, Yoshihiko Shimokawa, Katsunori Sasahara, Noriaki Yoda, Hiroyuki Sasabe, Mitsunari Suzuki, Ken Umehara
Delamanid (OPC-67683, Deltyba(TM) , nitro-dihydro-imidazooxazoles derivative) is approved for the treatment of adult pulmonary multidrug-resistant tuberculosis. The absorption, distribution, and excretion of delamanid-derived radioactivity were investigated after a single oral administration of (14) C-delamanid at 3 mg/kg to rats. In both male and female rats, radioactivity in blood and all tissues reached peak levels by 8 or 24 hours postdose, and thereafter decreased slowly. Radioactivity levels were 3- to 5-fold higher in lung tissue at time to maximum concentration compared with plasma...
January 16, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28091678/pepsin-egg-white-hydrolysate-modulates-gut-microbiota-in-zucker-obese-rats
#2
Teresa Requena, Marta Miguel, Marta Garcés-Rimón, M Carmen Martínez-Cuesta, Rosina López-Fandiño, Carmen Peláez
There is limited information that relates the intake of food-derived bioactive peptides and the gut microbiota. We have previously described a pepsin hydrolysate of egg white (EWH) that ameliorates fat accumulation and dyslipidemia, while reducing oxidative stress and inflammation markers in obese Zucker rats. The aim of this study was to associate the beneficial effects of EWH with gut microbiota changes in these animals. Obese Zucker rats received daily 750 mg kg(-1) EWH in drinking water for 12 weeks and faeces were analysed for microbial composition and metabolic compounds in comparison with Zucker lean rats and obese controls...
January 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#3
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28057750/whole-genome-sequences-and-classification-of-streptococcus-agalactiae-strains-isolated-from-laboratory-reared-long-evans-rats-rattus-norvegicus
#4
C Bodi Winn, J Dzink-Fox, Y Feng, Z Shen, V Bakthavatchalu, J G Fox
In collaboration with the CDC's Streptococcus Laboratory, we report here the whole-genome sequences of seven Streptococcus agalactiae bacteria isolated from laboratory-reared Long-Evans rats. Four of the S. agalactiae isolates were associated with morbidity accompanied by endocarditis, metritis, and fatal septicemia, providing an opportunity for comparative genomic analysis of this opportunistic pathogen.
January 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28034455/proliferative-enteropathy-caused-by-lawsonia-intracellularis-in-chickens
#5
T Ohta, K Kimura, K Katsuda, H Kobayashi, O Mikami, M Haritani, T Onodera
Proliferative enteropathy (PE) is an infectious disease caused by Lawsonia intracellularis (Li), an obligate intracellular bacterium. PE is endemic in swine herds and has been reported in a variety of mammals including horses, hamsters, rabbits, rats, guinea pigs, ferrets, foxes, dogs, sheep, deer and non-human primates. Avian cases are reported only in ratite birds, including emus and ostriches. Some studies show an absence of Lawsonia spp. infection in chickens. In this study, we performed morphological and bacteriological examinations on the intestines of two broiler chickens that had been condemned at a poultry slaughter plant in Japan due to intestinal haemorrhage, which was a result of focal coccidial enteritis...
December 26, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28034365/in-vivo-antibacterial-and-wound-healing-activities-of-roman-chamomile-chamaemelum-nobile
#6
Hossein Kazemian, Sobhan Ghafourian, Nourkhoda Sadeghifard, Behzad Badakhsh, Hamid Heidari, Asieh Taji, Aref Shavalipour, Reza Mohebi, Hadi Sedigh Ebrahim-Saraie, Hamidreza Houri, Reza Houshmandfar
BACKGROUND: Today considerable number of drugs are produced from plants. Several plants with antibacterial and healing applications are used in medicine such as Roman chamomile (Chamaemelum nobile L.). Wound infection is one of the most prevalent infections among infectious disease around the world. Due to appearance of drug resistance, researchers are now paying attention to medicinal plants. Therefore, this study was designed to investigate the antimicrobial and wound healing properties of C...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28033583/evaluation-of-antibacterial-antioxidant-and-nootropic-activities-of-tiliacora-racemosa-colebr-leaves-in-vitro-and-in-vivo-approach
#7
Vivek Kumar T, Vishalakshi M, Gangaraju M, Parijat Das, Pratiti Roy, Anindita Banerjee, Sayan Dutta Gupta
The antibacterial and antioxidant potential of Tiliacora racemosa leaf extracts in various solvents (methanolic, hexane, chloroform and ethyl acetate) was determined. Additionally, the presence of bisbenzylisoquinoline alkaloids in the plant prompted us to evaluate the nootropic activity of the methanolic extract in mice. Further, we seek to verify the nootropic effect by examining the anticholinesterase inhibition potential of the methanolic extract. The leaf extracts in various solvents were evaluated for their antibacterial and antioxidant activity by agar diffusion technique and α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method, respectively...
December 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28025886/comparative-analysis-of-the-rats-gut-microbiota-composition-in-animals-with-different-ginsenosides-metabolizing-activity
#8
Wei-Wei Dong, Fang-Ling Xuan, Fei-Liang Zhong, Jun Jiang, Songquan Wu, Donghao Li, Lin-Hu Quan
Following oral intake of Panax ginseng, major ginsenosides are metabolized to deglycosylated ginsenosides by gut microbiota before absorption into the blood. As the composition of gut microbiota varies between individuals, metabolic activities are significantly different. We selected 6 rats with low efficiency metabolism (LEM) and 6 rats with high efficiency metabolism (HEM) from 60 rats following oral administration of Panax ginseng extract, and analyzed their gut microbiota composition using Illumina HiSeq sequencing of the 16S rRNA gene...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28018327/correlation-of-gut-microbiota-composition-with-resistance-to-experimental-autoimmune-encephalomyelitis-in-rats
#9
Suzana Stanisavljević, Jovanka Lukić, Svetlana Soković, Sanja Mihajlovic, Marija Mostarica Stojković, Djordje Miljković, Natasa Golić
Multiple sclerosis is a chronic inflammatory disease of the central nervous system (CNS). It is widely accepted that autoimmune response against the antigens of the CNS is the essential pathogenic force in the disease. It has recently become increasingly appreciated that activated encephalitogenic cells tend to migrate toward gut associated lymphoid tissues (GALTs) and that interrupted balance between regulatory and inflammatory immunity within the GALT might have decisive role in the initiation and propagation of the CNS autoimmunity...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28005800/microbiological-and-histopathological-effects-of-nasal-packing-containing-probiotics-on-nasal-mucosa
#10
Ozan Gokdogan, Yusuf Kizil, Ilker Akyildiz, Ozan Ahlat, Ayse Kalkanci, Sabri Uslu, Fikret Ileri
BACKGROUND: Nasal packing is frequently used after surgical interventions to prevent bleeding and synecchia formation and for the treatment of diseases such as epistaxis. One of the most morbid complications of nasal packing applications is the toxic shock syndrome (TSS). Owing to the microbiological structure of nasal mucosa, antibiotics are administered to all patients who are applied nasal packages for prevention of TSS. AIM: The aim of this study is the evaluation of microbiological and histopathological changes taking place in nasal mucosa with nasal packing containing probiotics...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27999087/selye-s-general-adaptation-syndrome-stress-induced-gastro-duodenal-ulceration-and-ibd
#11
George Fink
Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a "general adaptation syndrome" (GAS). One of the main features of the GAS was the "formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix". This provided experimental evidence for the view based on clinical data that gastro-duodenal (peptic) ulcers could be caused by stress. This hypothesis was challenged by Marshall and Warren's Nobel-prize (2005) winning discovery of a causal association between Helicobacter pylori and peptic ulcers...
December 20, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27995243/nano-layered-magnesium-fluoride-reservoirs-on-biomaterial-surfaces-strengthen-polymorphonuclear-leukocyte-resistance-to-bacterial-pathogens
#12
Geyong Guo, Huaijuan Zhou, Qiaojie Wang, Jiaxing Wang, Jiaqi Tan, Jinhua Li, Ping Jin, Hao Shen
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, imposing a substantial burden on medical systems. In this context, understanding of nanomaterials-bacteria-cells interactions is of both fundamental and clinical significance. Herein, nano-MgF2 films were deposited on titanium substrate via magnetron sputtering. Using this platform, the antibacterial behavior and mechanism of the nano-MgF2 films were investigated in vitro and in vivo. It was found that, for S...
December 20, 2016: Nanoscale
https://www.readbyqxmd.com/read/27987755/controlled-release-of-cefazolin-sodium-antibiotic-drug-from-electrospun-chitosan-polyethylene-oxide-nanofibrous-mats
#13
Yousef Fazli, Zahra Shariatinia
Antimicrobial electrospun chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing cefazolin, fumed silica (F. silica) and cefazolin-loaded fumed silica nanoparticles (NPs) were produced for biomedical applications. The FE-SEM images revealed that the F. silica and F. silica-cefazolin NPs had average diameters of 40±10 and 60±15nm, respectively. Also, the fibers diameters were approximately 160±30, 90±20 and 70±15nm for the pure CS-PEO, CS-PEO-1% F. silica and CS-PEO-1% F. silica-0.5% cefazolin nanofibrous mats, respectively indicating addition of F...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987673/polyethyleneimine-brushes-effectively-inhibit-encrustation-on-polyurethane-ureteral-stents-both-in-dynamic-bioreactor-and-in-vivo
#14
Merve Gultekinoglu, Barış Kurum, Siyami Karahan, Didem Kart, Meral Sagiroglu, Nusret Ertaş, A Haluk Ozen, Kezban Ulubayram
Polyurethane (PU) ureteral stents have been widely used as biomedical devices to aid the flow of the urine. Due to the biofilm formation and encrustation complications it has been hindered their long term clinical usage. To overcome these complications, in this study, cationic polyethyleneimine (PEI) brushes grafted on PU stents and their performances were tested both in a dynamic biofilm reactor system (in vitro) and in a rat model (in vivo). Thus, we hypothesized that PEI brushes inhibit bacterial adhesion owing to the dynamic motion of brushes in liquid environment...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27982756/absorption-of-orally-administered-hyaluronan
#15
Mamoru Kimura, Takuya Maeshima, Takumi Kubota, Hitoshi Kurihara, Yasunobu Masuda, Yoshihiro Nomura
Hyaluronan (HA) has been utilized as a supplement. However, the absorption of orally administrated HA remains controversial. The degradation and absorption of HA in the intestine were investigated in this study. HA excretion into the feces, degradation in the intestinal tract, absorption through the large intestine, and translocation to the blood and skin were examined. HA administered orally was not detected in rat feces. HA was degraded by cecal content, but not by artificial gastric juice and intestinal juice...
December 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27982724/the-proteasome-inhibitor-bortezomib-inhibits-inflammatory-response-of-periodontal-ligament-cells-and-ameliorates-experimental-periodontitis-in-rats
#16
Lin Jiang, Jinlin Song, Xiaolei Hu, Hongmei Zhang, Enyi Huang, Yan Zhang, Feng Deng, Xiaomian Wu
BACKGROUND: Periodontitis is a chronic inflammatory disease initiated by bacteria and their virulence factors. Bortezomib (BTZ) is the first proteasome inhibitor for clinical treatment of malignancies. Its anti-cancer activity is accompanied by an anti-inflammatory effect. However, there are few reports about its anti-inflammatory effect and underlying mechanism in periodontal disease, especially on human periodontal ligament cells (hPDLCs), which are considered as a promising cell-based therapy for treating periodontitis...
December 16, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27981797/laserpitium-zernyi-hayek-flower-and-herb-extracts-phenolic-compounds-and-anti-edematous-antioxidant-and-antimicrobial-activities
#17
Višnja B Popović, Maja A Tomić, Radica M Stepanović-Petrović, Ana M Micov, Marina T Milenković, Silvana D Petrović, Ljuboš J Ušjak, Marjan S Niketić
Phenolic compounds and different biological activities of the dry methanol extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi Hayek (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27979776/safety-assessment-of-genetically-modified-milk-containing-human-beta-defensin-3-on-rats-by-a-90-day-feeding-study
#18
Xin Chen, Ming-Qing Gao, Dong Liang, Songna Yin, Kezhen Yao, Yong Zhang
In recent years, transgenic technology has been widely applied in many fields. There is concern about the safety of genetically modified (GM) products with the increased prevalence of GM products. In order to prevent mastitis in dairy cows, our group produced transgenic cattle expressing human beta-defensin-3 (HBD3) in their mammary glands, which confers resistance to the bacteria that cause mastitis. The milk derived from these transgenic cattle thus contained HBD3. The objective of the present study was to analyze the nutritional composition of HBD3 milk and conduct a 90-day feeding study on rats...
December 12, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27976972/the-protective-effects-of-probiotic-bacteria-on-cadmium-toxicity-in-rats
#19
Sinisa Djurasevic, Adel Jama, Nebojsa Jasnic, Predrag Vujovic, Milos Jovanovic, Dragana Mitic-Culafic, Jelena Knezevic-Vukcevic, Maja Cakic-Milosevic, Konstantin Ilijevic, Jelena Djordjevic
One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated...
December 15, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27973970/potential-renoprotective-effects-of-rosemary-and-thyme-against-gentamicin-toxicity-in-rats
#20
Amal S Abdel-Azeem, Amany M Hegazy, Hala M Zeidan, Khadiga S Ibrahim, Eman M El-Sayed
Gentamicin (GM) is a drug used commonly against gram-negative bacteria. Its therapeutic use is mainly limited by its nephrotoxicity. This investigation was aimed at evaluating the nephroprotective effects of rosemary (RM; Rosmarinus officinalis) and thyme (TV; Thymus vulgaris) against GM toxicity. Rats were divided into four groups. Normal control group was treated intraperitoneally (i.p.) with saline; positive control group was administered GM 60 mg/kg/day i.p.; RM group was co-administered 8% RM aqueous extract, 10 mL/kg/day, orally with GM; and TV group was co-administered 8% TV aqueous extract orally, 10 mL/kg/day with GM...
December 14, 2016: Journal of Dietary Supplements
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