keyword
https://read.qxmd.com/read/38496422/lipopolysaccharide-mediated-effects-of-the-microbiota-on-sleep-and-body-temperature
#1
Eva Szentirmai, Katelin Buckley, Ashley R Massie, Levente Kapas
Background Recent research suggests that microbial molecules translocated from the intestinal lumen into the host's internal environment may play a role in various physiological functions, including sleep. Previously, we identified that butyrate, a short-chain fatty acid, produced by intestinal bacteria, and lipoteichoic acid, a cell wall component of gram-positive bacteria induce sleep when their naturally occurring translocation is mimicked by direct delivery into the portal vein. Building upon these findings, we aimed to explore the sleep signaling potential of intraportally administered lipopolysaccharide, a primary component of gram-negative bacterial cell walls, in rats...
March 5, 2024: Research Square
https://read.qxmd.com/read/38494646/1-25-oh-2d3-supplementation-alleviates-gut-vascular-barrier-disruption-via-inhibition-of-s100b-adam10-pathway
#2
JOURNAL ARTICLE
Aiwen Feng, Cheng Li, Shaosheng Su, Yingyan Liu
Gut-vascular barrier (GVB) is the second barrier in mucosa to control systemic dissemination of gut bacteria. Severe burns induce enteroglial cells to produce S100B and endothelial cells to generate ADAM10 and cause vitamin D3 insufficiency/deficiency and GVB disruption. It is not clear whether vitamin D3 supplementation attenuates GVB damage via regulation of S100B/ADAM10 pathway. Here, GVB disruption was induced by 30% of total body surface area scalds. Rats were treated with 1,25(OH)2D3 (0.05, 0.5 or 5 μg/kg) or S100B monoclonal antibody (S100BmAb, 10 μg/kg) or GI254023X (ADAM10 inhibitor, 100 mg/kg)...
March 17, 2024: Tissue Barriers
https://read.qxmd.com/read/38481761/efficacy-of-rifampicin-combination-therapy-against-mrsa-prosthetic-vascular-graft-infections-in-a-rat-model
#3
JOURNAL ARTICLE
Mikkel Illemann Johansen, Maiken Engelbrecht Petersen, Emma Faddy, Anders Marthinsen Seefeldt, Alexander Alexandrovich Mitkin, Lars Østergaard, Rikke Louise Meyer, Nis Pedersen Jørgensen
Staphylococcus aureus is a major cause of prosthetic vascular graft or endograft infections (VGEIs) and the optimal choice of antibiotics is unclear. We investigated various antibiotic choices as either monotherapy or combination therapy with rifampicin against MRSA in vitro and in vivo . Fosfomycin, daptomycin and vancomycin alone or in combination with rifampicin was used against MRSA USA300 FPR3757. Each antibiotic was tested for synergism or antagonism with rifampicin in vitro, and all antibiotic regimens were tested against actively growing bacteria in media and non-growing bacteria in buffer, both as planktonic cells and in biofilms...
June 2024: Biofilm
https://read.qxmd.com/read/38480488/acute-emergence-of-the-intestinal-pathobiome-after-postinjury-pneumonia
#4
JOURNAL ARTICLE
Jennifer A Munley, Lauren S Kelly, Gwoncheol Park, Stacey K Drury, Gwendolyn S Gillies, Preston S Coldwell, Kolenkode B Kannan, Letitia E Bible, Philip A Efron, Ravinder Nagpal, Alicia M Mohr
BACKGROUND: Previous preclinical studies have demonstrated sex-specific alterations in the gut microbiome following traumatic injury or sepsis alone; however, the impact of host sex on dysbiosis in the setting of postinjury sepsis acutely is unknown. We hypothesized that multicompartmental injury with subsequent pneumonia would result in host sex-specific dysbiosis. METHODS: Male and proestrus female Sprague-Dawley rats (n = 8/group) were subjected to either polytrauma (PT) (lung contusion, hemorrhagic shock, cecectomy, bifemoral pseudofracture), PT plus 2-hours daily restraint stress (PT/RS), PT with postinjury day 1 pseudomonas aeruginosa pneumonia (PT + PNA), PT/RS with pneumonia (PT/RS + PNA), or naive controls...
March 14, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38474198/proanthocyanidins-ameliorate-lps-inhibited-osteogenesis-of-pdlscs-by-restoring-lysine-lactylation
#5
JOURNAL ARTICLE
Yaxin Wu, Xiangyao Wang, Yuxiao Zhang, Zhihao Wen, Yuanyuan Li, Kehan Zhang, Nuerlan Gosar, Qilin Li, Jing Mao, Shiqiang Gong
Periodontitis is a bacteria-induced inflammatory disease characterized by the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells (PDLSCs) are capable of differentiating into osteoblasts, which is an important stem cell source for endogenous periodontal tissue regeneration. Lysine lactylation (Kla) is a novel post-translational modification of proteins that is recently thought to be associated with osteogenic differentiation. Here, we found that lactylation levels are reduced both in the periodontal tissue of rats with periodontitis and lipopolysaccharide (LPS)-stimulated human PDLSCs...
March 3, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472276/inhibition-of-urease-mediated-ammonia-production-by-2-octynohydroxamic-acid-in-hepatic-encephalopathy
#6
JOURNAL ARTICLE
Diana Evstafeva, Filip Ilievski, Yinyin Bao, Zhi Luo, Boris Abramovic, Sunghyun Kang, Christian Steuer, Elita Montanari, Tommaso Casalini, Dunja Simicic, Dario Sessa, Stefanita-Octavian Mitrea, Katarzyna Pierzchala, Cristina Cudalbu, Chelsie E Armbruster, Jean-Christophe Leroux
Hepatic encephalopathy is a neuropsychiatric complication of liver disease which is partly associated with elevated ammonemia. Urea hydrolysis by urease-producing bacteria in the colon is often mentioned as one of the main routes of ammonia production in the body, yet research on treatments targeting bacterial ureases in hepatic encephalopathy is limited. Herein we report a hydroxamate-based urease inhibitor, 2-octynohydroxamic acid, exhibiting improved in vitro potency compared to hydroxamic acids that were previously investigated for hepatic encephalopathy...
March 12, 2024: Nature Communications
https://read.qxmd.com/read/38466531/yohimbine-treatment-alleviates-cardiac-inflammation-injury-and-improves-cardiac-hemodynamics-by-modulating-pro-inflammatory-and-oxidative-stress-indicators
#7
JOURNAL ARTICLE
Anjali Veeram, Taslim B Shaikh, Rajwinder Kaur, E Abhisheik Chowdary, Sai Balaji Andugulapati, Ramakrishna Sistla
Acute myocarditis, also known as myocardial inflammation, is a self-limited condition caused by systemic infection with cardiotropic pathogens, primarily viruses, bacteria, or fungi. Despite significant research, inflammatory cardiomyopathy exacerbated by heart failure, arrhythmia, or left ventricular dysfunction and it has a dismal prognosis. In this study, we aimed to evaluate the therapeutic effect of yohimbine against lipopolysaccharide (LPS) induced myocarditis in rat model. The anti-inflammatory activity of yohimbine was assessed in in-vitro using RAW 264...
March 11, 2024: Inflammation
https://read.qxmd.com/read/38461723/-epicatechin-ameliorates-type-2-diabetes-mellitus-by-reshaping-the-gut-microbiota-and-gut-liver-axis-in-gk-rats
#8
JOURNAL ARTICLE
Hongzhe Zeng, Changwei Liu, Liwei Wan, Liyuan Peng, Shuai Wen, Wenwen Fang, Hongyu Chen, Kuofei Wang, Xiaomei Yang, Jian'an Huang, Zhonghua Liu
As one of the most abundant plant polyphenols in the human diet, (-)-epicatechin (EC) can improve insulin sensitivity and regulate glucose homeostasis. However, the primary mechanisms involved in EC anti-T2DM benefits remain unclear. The present study explored the effects of EC on the gut microbiota and liver transcriptome in type 2 diabetes mellitus (T2DM) Goto-Kakizaki rats for the first time. The findings showed that EC protected glucose homeostasis, alleviated systemic oxidative stress, relieved liver damage, and increased serum insulin...
March 6, 2024: Food Chemistry
https://read.qxmd.com/read/38459675/in-vitro-and-in-vivo-study-of-antibacterial-and-anti-encrustation-coating-on-ureteric-stents
#9
JOURNAL ARTICLE
Yue Zhao, Guo Chen, Suliya Yushanjiang, Meng Zhao, Hui Yang, Ran Lu, Rui Qu, Yi Dai, Luo Yang
OBJECTIVES: To investigate the ability of propolis-coated ureteric stents to solve complications, especially urinary tract infections (UTIs) and crusting, in patients with long-term indwelling ureteric stents through antimicrobial and anti-calculus activities. MATERIALS AND METHODS: Polyurethane (PU) ureteric stents were immersed in the ethanol extract of propolis (EEP), a well-known antimicrobial honeybee product, and subjected to chemical, hydrophilic, and seismic tests...
March 8, 2024: BJU International
https://read.qxmd.com/read/38455958/comparative-evaluation-of-antioxidant-activity-total-phenolic-content-anti-inflammatory-and-antibacterial-potential-of-euphorbia-derived-functional-products
#10
JOURNAL ARTICLE
Rania Benjamaa, Hamza Elbouny, Hajare Errati, Abdelkarim Moujanni, Neha Kaushik, Ravi Gupta, OumKeltoum Ennibi, Boubker Nasser, Eun Ha Choi, Nagendra Kumar Kaushik, Abdelkhalid Essamadi
This study assessed the medicinal properties of Euphorbia resinifera O. Berg (E. resinifera) and Euphorbia officinarum subsp echinus (Hook.f. and Coss.) Vindt ( Euphorbia echinus , known for their pharmaceutical benefits. Extracts from their flowers, stems, propolis, and honey were examined for phenolic content, antioxidant, anti-inflammatory, and antibacterial activities. Total phenolic content (TPC), total flavonoid content (TFC), and total condensed tannin (TCC) were determined using specific methods. Antioxidant potential was assessed through various tests including DPPH, FRAP, ABTS, and Total antioxidant capacity...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38450172/electroacupuncture-at-st25-corrected-gut-microbial-dysbiosis-and-snpc-lipid-peroxidation-in-parkinson-s-disease-rats
#11
JOURNAL ARTICLE
Xuan-Ming Hu, Li-Zhe-Xiong Song, Zhi-Zi Zhang, Xi Ruan, Hai-Chang Li, Zhi Yu, Lin Huang
INTRODUCTION: Parkinson's disease (PD) remains one kind of a complex, progressive neurodegenerative disease. Levodopa and dopamine agonists as widely utilized PD therapeutics have not shown significant positive long-term outcomes. Emerging evidences indicate that electroacupuncture (EA) have potential effects on the therapy of nervous system disorders, particularly PD, but its specific underlying mechanism(s) remains poorly understood, leading to the great challenge of clinical application and management...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38433148/esmolol-increases-the-fecal-abundance-of-lactobacillus-in-a-rat-model-of-sepsis
#12
JOURNAL ARTICLE
Bo Yao, Fu-Hua Wang, Xiao-Ning Han, Jun Yang, Ping Xue, Qi Qi, Guang-Yao Wei, Jin-Yan Xing
BACKGROUND: Disorders of the gut microbiome could be responsible for the progression of multiple organ dysfunction syndrome. In this study, we examined the effect of esmolol on the gut microbiome in a rat model of sepsis induced by cecal ligation and puncture (CLP). METHODS: The animals (n = 32) were randomly divided into 3 groups: Sham group (sham operation + normal saline treatment, n = 8), CLP group (cecal ligation and puncture + normal saline treatment, n = 12), and CLP + ESM group (cecal ligation and puncture + esmolol treatment, n = 12)...
March 4, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38431610/inhibitory-and-preventive-effects-of-arnebia-euchroma-royle-johnst-root-extract-on-streptococcus-mutans-and-dental-caries-in-rats
#13
JOURNAL ARTICLE
Zeyu Wu, Jie Song, Yangyang Zhang, Xiyu Yuan, Jin Zhao
BACKGROUND: Dental caries is one of the prevalent conditions that threaten oral health. Arnebia euchroma (Royle) Johnst. root (AR) extracts exhibit anti-inflammatory, anti-cancer, and antibacterial properties. This study was designed to investigate the antibacterial impact of AR extract on Streptococcus mutans (S. mutans) UA159 and the anti-caries effect on rats. METHODS: The antibacterial activity of AR extract against S. mutans and its biofilm was determined using the bacterial sensitivity test, the biofilm sensitivity test, and the live-dead staining technique...
March 2, 2024: BDJ Open
https://read.qxmd.com/read/38431415/multifunctional-polysaccharide-metal-polyphenol-double-crosslinked-hydrogel-for-infected-wound
#14
JOURNAL ARTICLE
Yun Duan, Fuchen Jiang, Qing Li, Arlene McDowell, Yingxi Li, Ying Wang, Shuang Liu, Chen Zhang, Xiaoli Pan
Bacterial-infected wounds present a significant challenge in the medical field, posing a severe threat to public health. Traditional wound dressings have limited efficacy in treating bacterial-infected wounds, and antibiotics suffer from cytotoxicity and drug resistance. Consequently, an urgent requirement exists for developing multifunctional wound dressings capable of providing superior antimicrobial activity and expediting wound repair. In recent years, chitosan-based natural polysaccharide hydrogels have garnered attention for their biocompatibility, antimicrobial properties, and ability to aid in hemostasis...
May 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38423087/nitrogen-doped-carbon-quantum-dots-as-a-novel-treatment-for-black-fungal-bone-infections-mucormycosis-in-vitro-and-in-vivo-study
#15
JOURNAL ARTICLE
Amany Belal, Atiah H Almalki, Ahmed A Farghali, Rehab Mahmoud, R R Atta, Abeer Enaiet Allah, Walid Hamdy Hassan, Sangmin Lee, Amna A Kotp, Doaa Essam, Ahmed H E Hassan, Mohammed M Ghoneim, Fatma I Abo El-Ela, Abdalla Abdelwahab
Most fungal bone and joint infections (arthritis) are caused by Mucormycosis ( Mucor indicus ). These infections may be difficult to treat and may lead to chronic bone disorders and disabilities, thus the use of new antifungal materials in bone disorders is vital, particularly in immunocompromised individuals, such as those who have contracted coronavirus disease 2019 (COVID-19). Herein, we reported for the first time the preparation of nitrogen-doped carbon quantum dots (N/CQDs) and a nitrogen-doped mesoporous carbon (N/MC) using a quick micro-wave preparation and hydrothermal approach...
December 2024: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/38422109/effects-of-nano-cerium-dioxide-on-intestinal-microflora-in-rats-by-oral-subchronic-exposure
#16
JOURNAL ARTICLE
Qianru Ye, Dantong Jia, Jun Ji, Yang Liu, Gang Wu
OBJECTIVE: To investigate intestinal toxicity in rats and the effects of Nano-cerium dioxide on intestinal flora in rats after oral sub-chronic exposure. METHOD: Forty healthy male SD rats were randomly divided into four groups: a control group (deionized water) and three groups treated with different doses of Nano-ceria (e.g., 20 mg/kg, 100 mg/kg, and 500 mg/kg), with 10 rats in each group. The rats were given intragastric administrations (every other day) for 90 days...
2024: PloS One
https://read.qxmd.com/read/38419135/emerging-use-of-air-edna-and-its-application-to-forensic-investigations-a-review
#17
REVIEW
Mariya Goray, Duncan Taylor, Emily Bibbo, Chiara Fantinato, Ane Elida Fonneløp, Peter Gill, Roland A H van Oorschot
Biological material is routinely collected at crime scenes and from exhibits and is a key type of evidence during criminal investigations. Improvements in DNA technologies allow collection and profiling of trace samples, comprised of few cells, significantly expanding the types of exhibits targeted for DNA analysis to include touched surfaces. However, success rates from trace and touch DNA samples tend to be poorer compared to other biological materials such as blood. Simultaneously, there have been recent advances in the utility of environmental DNA collection (eDNA) in identification and tracking of different biological organisms and species from bacteria to naked mole rats in different environments, including, soil, ice, snow, air and aquatic...
February 28, 2024: Electrophoresis
https://read.qxmd.com/read/38416001/rat-peri-implantitis-models-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Gufeng Liu, Huifang Sun, Bin Shi, Haibin Xia, Tao Wu
PURPOSE: To review experimental peri-implantitis studies using rat models and summarize different peri-implantitis induction techniques and evaluate their effectiveness. MATERIALS AND METHODS: Electronic searches were conducted by two independent examiners to address the following issues. Meta-analyses explored the marginal bone loss (MBL) of four types of peri-implantitis induction methods in rats. The detailed induction tactics-such as the implant design, implant size, surgical process, time cost, induction methods, and endpoint measurements-were summarized...
February 27, 2024: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/38413810/drinkable-in-situ-forming-tough-hydrogels-for-gastrointestinal-therapeutics
#19
JOURNAL ARTICLE
Gary W Liu, Matthew J Pickett, Johannes L P Kuosmanen, Keiko Ishida, Wiam A M Madani, Georgia N White, Joshua Jenkins, Sanghyun Park, Vivian R Feig, Miguel Jimenez, Christina Karavasili, Nikhil B Lal, Matt Murphy, Aaron Lopes, Joshua Morimoto, Nina Fitzgerald, Jaime H Cheah, Christian K Soule, Niora Fabian, Alison Hayward, Robert Langer, Giovanni Traverso
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming tough (LIFT) hydrogels that bridge the advantages of solid and liquid dosage forms. LIFT hydrogels form directly in the stomach through sequential ingestion of a crosslinker solution of calcium and dithiol crosslinkers, followed by a drug-containing polymer solution of alginate and four-arm poly(ethylene glycol)-maleimide...
February 27, 2024: Nature Materials
https://read.qxmd.com/read/38407252/streptobacillus-moniliformis-and-igm-and-igg-immune-response-in-patient-with-endocarditis-1
#20
JOURNAL ARTICLE
Philipp Mathé, Katja Schmidt, Viktoria Schindler, Ahmad Fawzy, Tilman Schultze, Reinhard E Voll, David Pauli, Milena Popova, Franziska Schauer, Tobias Eisenberg
We describe a case of endocarditis caused by Streptobacillus moniliformis bacteria, a known cause of rat-bite fever, in a 32-year-old woman with pet rats in Germany. The patient had a strong serologic response, with high IgM and IgG titers. Serologic analysis is a promising tool to identify S. moniliformis bacterial infection.
March 2024: Emerging Infectious Diseases
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