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https://www.readbyqxmd.com/read/28916286/toxicology-studies-of-primycin-sulphate-using-a-three-dimensional-3d-in-vitro-human-liver-aggregate-model
#1
Ágota Pénzes, Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Zsanett A Péteri, Judit Bovári-Biri, Csaba Fekete, György Miskei, Krisztián Kvell, Judit E Pongrácz
Primycin-sulphate is a highly effective compound against Gram (G) positive bacteria. It has a potentially synergistic effect with vancomycin and statins which makes primycin-sulphate a potentially very effective preparation. Primycin-sulphate is currently used exclusively in topical preparations such as in in vitro animal hepatocyte and neuromuscular junction studies (in mice, rats, snakes, frogs) as well as in in vitro human red blood cell experiments. During these studies, the use of primycin-sulphate resulted in reduced cellular membrane integrity and modified ion channel activity...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28911652/microbiological-histological-and-biochemical-evidence-for-the-adverse-effects-of-food-azo-dyes-on-rats
#2
Khaled Elbanna, Osama Mohamed Sarhan, Manal Khider, Mohamed Elmogy, Hussein Hasan Abulreesh, Mohamed Rabie Shaaban
In this study, 120 lactic acid bacterial strains from different fermented dairy products as well as 10 bacterial intestinal isolates were evaluated for in vitro and in vivo degradation of various food azo dyes. Of these isolates, lactic acid bacteria (LAB) strains 13 and 100 and the intestinal isolates Ent2 and Eco5 exhibited 96-98% degradation of the tested food azo dyes within 5-6 hours. High performance liquid chromatography mass spectra of sunset yellow (E110) and carmoisine (E122) anaerobic degradation products by the intestinal isolates showed that they were structurally related to toxic aromatic amines...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911609/antibacterial-and-laxative-activities-of-strictinin-isolated-from-pu-er-tea-camellia-sinensis
#3
Sheng-Kuo Hsieh, Jun-Rui Xu, Nan-Hei Lin, Yue-Chiun Li, Guan-Heng Chen, Ping-Chung Kuo, Wen-Ying Chen, Jason T C Tzen
Strictinin, the major phenolic compound in Pu'er teas produced from young leaves and buds of wild trees, was isolated to evaluate its antibacterial and laxative activities. The minimum inhibitory concentrations of strictinin against Propionibacterium acnes and Staphylococcus epidermidis were determined as 250 μM and 2000 μM, respectively, apparently higher than those of several antibiotics commonly used for bacterial infections. The additive and synergistic effects on the inhibitory activities of strictinin combined with other commercial antibiotics were observed in two bacteria tested in this study via the analysis of fractional inhibitory concentrations...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28877164/in-vivo-therapeutic-effect-of-combination-treatment-with-metformin-and-scutellaria-baicalensis-on-maintaining-bile-acid-homeostasis
#4
Kyungsun Han, Shambhunath Bose, Jing-Hua Wang, Soo-Kyoung Lim, Young-Won Chin, Young-Mi Kim, Han-Seok Choi, Hojun Kim
The radix of Scutellaria baicalensis (SB) is a herb widely used in traditional Chinese medicine to treat metabolic diseases. Several main components, including baicalin and wogonoside, possess anti-dyslipidemia, anti-obesity and anti-diabetic effects. We hypothesized that co-administration of SB extract and metformin exerts a better effect on obesity-induced insulin resistance and lipid metabolism than treatment with metformin alone. We compared the effect of metformin (100 mg/10 mL/kg/day) alone with co-administration of metformin (100 mg/5 mL/kg/day) and SB extract (200 mg/5 mL/kg/day) on Otsuka Long Evans Tokushima Fatty rats, a useful model of type II diabetes with obesity, and used Long-Evans Tokushima Otsuka rats as a control...
2017: PloS One
https://www.readbyqxmd.com/read/28876684/differences-in-microbiome-in-rat-models-of-cardiovascular-disease
#5
A Thiba, C A Umar, S Myende, E Nweke, K Rumbold, G Candy
BACKGROUND: Recent studies have underscored the important role the gut metagenome in various human diseases, including diabetes and obesity. Hypertension is a major risk factor for cardiovascular disease, stroke, and heart and kidney failure, and affects approximately 25% of the world's adult population. The cause of essential hypertension remains unknown. Patients given antibiotics show blood pressure changes and transfer of gut bacteria from hypertensive to normal WKY rats resulted in the latter developing hypertension...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28867763/utilization-of-fishery-processing-by-product-squid-pens-for-%C3%AE-glucosidase-inhibitors-production-by-paenibacillus-sp
#6
Van Bon Nguyen, Anh Dzung Nguyen, San-Lang Wang
The supernatants (the solution part received after centrifugation) of squid pens fermented by four species of Paenibacillus showed potent inhibitory activity against α-glucosidases derived from yeast (79-98%) and rats (76-83%). The inhibition of acarbose-a commercial antidiabetic drug, used against yeast and rat α-glucosidases-was tested for comparison; it showed inhibitory activity of 64% and 88%, respectively. Other chitinolytic or proteolytic enzyme-producing bacterial strains were also used to ferment squid pens, but no inhibition activity was detected from the supernatants...
August 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28867695/development-of-a-prodrug-of-levofloxacin-to-avoid-chelation-with-al-3-and-of-pemetrexed-dimedoxomil-esters-for-oral-administration
#7
Kenji Matsuyama
 An ethoxycarbonyl 1-ethyl hemiacetal ester of levofloxacin (LVFX-EHE) avoids insoluble chelate formation with metal-containing drugs in the intestinal tract and is rapidly hydrolyzed to the parent drug. Furthermore, the minimum inhibitory concentration confirms that LVFX-EHE is less likely to cause pseudomembranous colitis because of less susceptibility to normal intestinal bacteria flora. Pemetrexed dimedoxomil, the prodrug of pemetrexed, was synthesized via reaction with medoxomil bromide after modification of L-glutamate with the tert-butyloxycarbonyl protecting group (BOC), followed by hydrolysis of the BOC moiety with trifluoroacetic acid (TFA) in CH2Cl2 at a temperature of 0°C for 2 h...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28863368/postprandial-effect-to-decrease-soluble-epoxide-hydrolase-activity-roles-of-insulin-and-gut-microbiota
#8
Jun Yang, Young Taek Oh, Debin Wan, Richard M Watanabe, Bruce D Hammock, Jang H Youn
Epoxides of free fatty acids (FFAs), especially epoxyeicosatrienoic acids (EETs), are lipid mediators with beneficial effects in metabolic and cardiovascular (CV) health. FFA epoxides are quickly metabolized to biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases EET levels, improves glucose homeostasis and CV health and is proposed as an effective strategy for the treatment of diabetes and CV diseases. Here, we show evidence that sEH activity is profoundly reduced in postprandial states in rats; plasma levels of 17 sEH products (i...
July 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28858205/impact-of-novel-prebiotic-galacto-oligosaccharides-on-various-biomarkers-of-colorectal-cancer-in-wister-rats
#9
Tahir Rasool Qamar, Sanaullah Iqbal, Fatima Syed, Muhammad Nasir, Habib Rehman, Muhammad Aamir Iqbal, Rui Hai Liu
Colorectal cancer (CRC) is one of the leading causes of cancer deaths around the globe. Bioactive food ingredients such as prebiotics have protective potential in colon cancer. Data on galacto-oligosaccharides (GalOS) against CRC are very limited and GalOS used in this study have β-1,6 and β-1,3 as major glycosidic linkages and, to our best knowledge, were never used before against any cancer treatment. This study aims to investigate the protective role of novel GalOS against various biomarkers of CRC including aberrant crypt foci (ACF), bacterial enzymes and short chain fatty acids (SCFA) in a rodent model induced with 1,2-dimethylhydrazine dihydrochloride (DMH)...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28857681/expression-and-purification-of-the-extracellular-domains-of-human-glycoprotein-vi-gp-vi-and-the-receptor-for-advanced-glycation-end-products-rage-from-rattus-norvegicus-in-leishmania-tarentolae
#10
Thomas Langer, Carsten Corvey, Katja Kroll, Oliver Boscheinen, Thomas Wendrich, Werner Dittrich
Glycosylation is one of the most complex posttranslational modifications and may have significant influence on the proper function of the corresponding proteins. Bacteria and yeast are, because of easy handling and cost reasons, the most frequently used systems for recombinant protein expression. Bacteria generally do not glycosylate proteins and yeast might tend to hyperglycosylate. Insect cell and mammalian cell based expression system are able to produce complex N-glycosylation structures, but are more complex to handle and more expensive...
August 31, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28856909/lactococcus-lactis-and-lactobacillus-salivarius-bgbu1-4-differently-modulate-early-immunological-response-of-wistar-rats-co-administered-with-listeria-monocytogenes
#11
J Lukic, I Jancic, N Mirkovic, B Bufan, J Djokic, M Milenkovic, J Begovic, I Strahinic, J Lozo
In the light of the increasing resistance of bacterial pathogens to antibiotics, one of the main global strategies in applied science is development of alternative treatments, which would be safe both for the host and from the environmental perspective. Accordingly, the aim of this study was to test whether two lactic acid bacteria (LAB) strains, Lactococcus lactis BGBU1-4 and Lactobacillus salivarius BGHO1, could be applied as safe supplements for Listeria infection. Two major research objectives were set: to compare the effects of BGBU1-4 and BGHO1 on early immune response in gut tissue of Wistar rats co-administered with Listeria monocytogenes ATCC19111 and next, to test how this applies to their usage as therapeutics in acute ATCC19111 infection...
August 31, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28852094/unraveling-the-gut-microbiome-of-the-long-lived-naked-mole-rat
#12
Tewodros Debebe, Elena Biagi, Matteo Soverini, Susanne Holtze, Thomas Bernd Hildebrandt, Claudia Birkemeyer, Dereje Wyohannis, Alemayehu Lemma, Patrizia Brigidi, Vulk Savkovic, Brigitte König, Marco Candela, Gerd Birkenmeier
The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model to study the biology of healthy aging and longevity. Here we characterize for the first time the intestinal microbial ecosystem of the naked mole-rat in comparison to humans and other mammals, highlighting peculiarities related to the specific living environment, such as the enrichment in bacteria able to utilize soil sulfate as a terminal electron acceptor to sustain an anaerobic oxidative metabolism...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851350/preventive-effects-of-the-novel-antimicrobial-peptide-nal-p-113-in-a-rat-periodontitis-model-by-limiting-the-growth-of-porphyromonas-gingivalis-and-modulating-il-1%C3%AE-and-tnf-%C3%AE-production
#13
Hong-Yan Wang, Li Lin, Wei Fu, Hui-Yuan Yu, Ning Yu, Li-Si Tan, Jya-Wei Cheng, Ya-Ping Pan
BACKGROUND: P-113 (AKRHHGYKRKFH-NH2) is a 12-amino-acid histidine-rich peptide derived from histatin 5 that is highly degradable in high salt concentrations and biological fluids such as serum, plasma and saliva. Nal-P-113, a novel antimicrobial peptide whose histidine residues are replaced by the bulky amino acids β-naphthylalanine, causes the antimicrobial peptide to retain its bactericidal activity even in physiological environments. This study evaluated the effect of the novel antimicrobial peptide Nal-P-113 in a rat periodontitis model and the mechanisms of action of Nal-P-113 for suppressing periodontitis...
August 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28844298/uv-vis-degradation-of-%C3%AE-tocopherol-in-a-model-system-and-in-a-cosmetic-emulsion-structural-elucidation-of-photoproducts-and-toxicological-consequences
#14
Ségolène De Vaugelade, Edith Nicol, Svetlana Vujovic, Sophie Bourcier, Stéphane Pirnay, Stéphane Bouchonnet
The UV-vis photodegradation of α-tocopherol was investigated in a model system and in a cosmetic emulsion. Both gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) and high performance liquid chromatography coupled with ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (LC-UHR-MS) were used for photoproducts structural identification. Nine photoproduct families were detected and identified based on their mass spectra and additional experiments with α-tocopherol-d9; phototransformation mechanisms were postulated to rationalize their formation under irradiation...
August 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28842287/determining-potential-of-pmma-as-a-depot-for-rifampin-to-treat-recalcitrant-orthopaedic-infections
#15
Stefanie M Shiels, David J Tennent, Kevin S Akers, Joseph C Wenke
BACKGROUND: Open fractures are often complicated by infection. In cases of severe soft tissue and vascular injury, systemic antibiotics may be ineffective due to their inability to reach and provide direct antimicrobial activity to the zone of injury. High antibiotic concentrations within the wound can be achieved with reduced systemic toxicity by using local antibiotic delivery. As bacteria associated with musculoskeletal injuries frequently form biofilms, antibiotic selection is important...
August 16, 2017: Injury
https://www.readbyqxmd.com/read/28832120/single-continuous-near-infrared-laser-triggered-photodynamic-and-photothermal-ablation-of-antibiotic-resistant-bacteria-using-effective-targeted-copper-sulfide-nanoclusters
#16
Xiaomei Dai, Yu Zhao, Yunjian Yu, Xuelei Chen, Xiaosong Wei, Xinge Zhang, Chaoxing Li
The emergence of antibiotic-resistant bacterial strains has made conventional antibiotic therapies less efficient. The development of a novel nanoantibiotic approach for efficiently ablating such bacterial infections is becoming crucial. Herein, a collection of poly(5-(2-ethyl acrylate)-4-methylthiazole-g-butyl)/copper sulfide nanoclusters (PATA-C4@CuS) was synthesized for efficient capture and effective ablation of levofloxacin-resistant Gram-negative and Gram-positive bacteria upon tissue-penetrable near-infrared (NIR) laser irradiation...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28831546/dietary-proteins-rapidly-altered-the-microbial-composition-in-rat-caecum
#17
Fan Zhao, Zixin Huang, Guanghong Zhou, He Li, Xinglian Xu, Chunbao Li
Dietary proteins can alter gut microbial diversity. However, little is known about how gut bacteria respond to dietary proteins during short-term feeding. In the present study, PCR-DGGE analysis was performed to compare changes in gut microbial composition in rat caecum after rats were fed proteins from soy, pork, beef, chicken, fish and casein (control) for 2, 7 and 14 days. On day 2, differences were observed in microbial composition between groups of red meat (pork and beef) and white meat (chicken and fish) proteins...
August 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28826355/human-beta-defensin-2-and-3-mitigate-the-negative-effects-of-bacterial-contamination-on-bone-healing-in-rat-calvarial-defect
#18
Po-Hui Lee, Meng-Yu Chen, Yu-Lin Lai, Shyh-Yuan Lee, Hen-Li Chen
Bacterial contamination during the healing of bone defects frequently compromises the effects of bone regenerative therapy. Human beta-defensin-2 (hBD2) and -3 (hBD3) are antimicrobial peptides of human innate immune system with a broad antibacterial spectrum and rare bacterial resistance. The purpose of this study was to determine the effect of hBD2 and hBD3 on the healing of bacteria-contaminated bone defects. Rat bone marrow stromal cells (BMSCs) were infected with adenovirus to overexpress hBD2 or hBD3...
August 21, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28821814/bifidobacterium-pseudocatenulatum-li09-and-bifidobacterium-catenulatum-li10-attenuate-d-galactosamine-induced-liver-injury-by-modifying-the-gut-microbiota
#19
Daiqiong Fang, Ding Shi, Longxian Lv, Silan Gu, Wenrui Wu, Yanfei Chen, Jing Guo, Ang Li, Xinjun Hu, Feifei Guo, Jianzhong Ye, Yating Li, Lanjian Li
The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of liver damage. We hypothesized that oral administration of specific Bifidobacterium strains isolated from healthy guts could attenuate liver injury. Five strains were tested in this study. Acute liver injury was induced by D-galactosamine after pretreating Sprague-Dawley rats with the Bifidobacterium strains, and liver function, liver and ileum histology, plasma cytokines, bacterial translocation and the gut microbiome were assessed...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821417/single-species-versus-dual-species-probiotic-supplementation-as-an-emerging-therapeutic-strategy-for-obesity
#20
G Karimi, R Jamaluddin, N Mohtarrudin, Z Ahmad, H Khazaai, M Parvaneh
BACKGROUND AND AIM: Recent studies have reported beneficial effects of specific probiotics on obesity. However, the difference in the anti-obesity effects of probiotics as single species and dual species is still uncertain. Therefore, we aimed to compare the efficacy of single and dual species of bacteria on markers of obesity in high-fat diet-induced obese rats. METHODS AND RESULTS: A total of 40 male Sprague-Dawley rats were assigned to one of five groups of varying diets as follows: standard diet, high fat diet (HFD), HFD supplemented with Lactobacillus casei strain Shirota, HFD supplemented with Bifidobacterium longum and HFD supplemented with a mixture of these two bacterial species...
July 8, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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