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Gastric cancer AND radiotherapy

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https://www.readbyqxmd.com/read/28078109/prognostic-impact-of-tumour-associated-b-cells-and-plasma-cells-in-oesophageal-and-gastric-adenocarcinoma
#1
Richard Fristedt, David Borg, Charlotta Hedner, Jonna Berntsson, Björn Nodin, Jakob Eberhard, Patrick Micke, Karin Jirström
BACKGROUND: While it is well established that the cell-mediated immune response plays an important role in cancer progression and spread, the role of the humoral immune response in this regard has been less studied. According to the existing literature, dense infiltration of B cells or plasma cells appears to correlate mainly with an improved prognosis in several types of cancer, but their prognostic impact in oesophageal and gastric cancer has not yet been described. METHODS: Immunohistochemistry was applied on tissue microarrays (TMA) to assess the stromal density of B cells (CD20+) and plasma cells [CD138+ or immunoglobulin kappa C (IGKC+)] in chemo-/radiotherapy-naive tumours from a consecutive cohort of 174 patients with resected oesophageal or gastric adenocarcinoma...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28047134/th-cd-202-11-implications-for-online-adaptive-and-non-adaptive-radiotherapy-of-gastic-and-gastroesophageal-junction-cancers-using-mri-guided-radiotherapy
#2
K Mittauer, M Geurts, R Toya, M Bassetti, P Harari, B Paliwal, J Bayouth
PURPOSE: Radiotherapy for gastric and gastroesophageal junction (GEJ) tumors commonly requires large margins due to deformation, motion and variable changes of the stomach anatomy, at the risk of increased normal tissue toxicities. This work quantifies the interfraction variation of stomach deformation from daily MRI-guided radiotherapy to allow for a more targeted determination of margin expansion in the treatment of gastric and GEJ tumors. METHODS: Five patients treated for gastric (n=3) and gastroesophageal junction (n=2) cancers with conventionally fractionated radiotherapy underwent daily MR imaging on a clinical MR-IGRT system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27991022/-minimal-invasive-esophageal-resection-with-anastomosis-on-the-neck-mckeown-our-experiences-after-20-cases
#3
Elemér Mohos, Attila Nagy, György Szabados, György Réti, Tamás Kovács, Zoltán Jánó, Csaba Berki, József Mohay, Lóránt Szabó, Krisztina Bene, Gábor Bognár, Myroslav Horzov, Petra Mohos, Gábor Sándor, Gábor Tornai, Péter Szenkovits, Tibor Nagy, Csaba Orbán, Vivien Herpai
OBJECTIVE: Esophageal resection is a traumatic intervention usually performed on patients with poor condition, resulting high mortality and morbidity. To improve the high incidence of complications, minimal invasive interventions were introduced. The results of the thoracoscopically and laparoscopically performed esophageal resection (McKeown) was investigated after 20 cases and the technical details of the surgical intervention are presented. PATIENTS AND METHOD: 20 thoracoscopic esophageal resection with laparoscopic gastric tube formation (sec...
December 2016: Magyar Sebészet
https://www.readbyqxmd.com/read/27931221/the-patterns-and-timing-of-recurrence-after-curative-resection-for-gastric-cancer-in-china
#4
Dan Liu, Ming Lu, Jian Li, Zuyao Yang, Qi Feng, Menglong Zhou, Zhen Zhang, Lin Shen
BACKGROUND: The recurrence of gastric cancer after curative resection had adverse effects on patients' survival. The treatment presence varied from different countries. The aims of this study were to understand the recurrence incidence, patterns, and timing and to explore the risk factors in China. METHODS: One thousand three hundred four patients who undergoing curative resection from more than 100 hospitals between January 1st 1986 and September 1st 2013, were surveyed in detail...
December 8, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27881015/predictors-of-survival-in-patients-with-brain-metastases-from-gastric-cancer
#5
D Rades, T Bartscht, S E Schild
This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. Twelve patients received whole-brain radiotherapy (WBRT), four stereotactic radiosurgery and six neurosurgery plus WBRT. Treatment regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, tumor site, number of brain metastases, extra-cranial metastases and interval between cancer diagnosis and brain metastases were evaluated for survival...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27821077/a-case-series-of-intestinal-adenomatous-polyposis-of-unidentified-etiology-a-late-effect-of-irradiation
#6
Lisanne Sara Rigter, Frank G J Kallenberg, Barbara Bastiaansen, Theo A M van Os, Floor E van Leeuwen, Monique Esther van Leerdam, Evelien Dekker
BACKGROUND: In a large number of patients with multiple gastrointestinal adenomatous polyps, no causal germline mutation can be found. Non-genetic factors may contribute to the development of adenomatous polyps in these unexplained polyposis patients. In the development of gastrointestinal cancer, prior exposure to abdominal radiotherapy has been identified as such a factor, as it increases the gastrointestinal cancer risk in cancer survivors. A relationship of radiotherapy with intestinal polyposis, however, has not yet been described...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27775797/multimodal-approach-of-advanced-gastric-cancer-based-therapeutic-algorithm
#7
S Berretta, M Berretta, F Fiorica, R Di Francia, P Magistri, G Bertola, R Fisichella, V Canzonieri, F Di Benedetto, G Tarantino
Gastric cancer (GC) is the third leading cause of cancer death in both sexes worldwide, with the highest estimated mortality rates in Eastern Asia and the lowest in Northern America. However, the availability of modern treatment has improved the survival and the prognosis is often poor due to biological characteristics of the disease. In oncology, we are living in the "Era" of target treatment and, to know biological aspects, prognostic factors and predictive response informations to therapy in GC is mandatory to apply the best strategy of treatment...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27766382/-cervical-cancer-update-on-morphology
#8
L-C Horn, C E Brambs, R Handzel, S Lax, I Sändig, D Schmidt, K Schierle
The World Health Organization (WHO) classification from 2014 differentiates between different subtypes of mucinous adenocarcinoma of the uterine cervix. A gastric subtype was recently described that showed no association with high-risk human papillomavirus (HPV) infections, has a poor prognosis, is mainly diagnosed in women of Asian origin and can occur in patients with Peutz-Jeghers syndrome. Although no clear grading system has been recommended in the WHO classification, it is likely that grading of adenocarcinomas of the uterine cervix will partly be based on the different patterns of invasion...
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27740935/a-novel-grade-lymph-node-ratio-model-predicts-the-prognosis-of-the-advanced-gastric-cancer-patients-after-neoadjuvant-radiotherapy
#9
Jianjun Liu, Mingxue Su, Jing Wang, Gan Zhang, Jing Zhou, Anqing Zhang, Zixue Ren, Xucai Zheng, Shikai Hong, Shengying Wang, Rongxin Zhang
Although local advanced gastric cancer (AGC) could benefit from neoadjuvant radiotherapy (NRT), there are few studies evaluating patients' survival after NRT. In current study, we aimed to investigate the value of prognostic factors in AGC patients after NRT and to evaluate whether post-therapy pathological characteristics were predictive factors in these patients. We retrospectively analyzed AGC patients who underwent NRT from Surveillance, Epidemiology, and End Results (SEER) Database. The patients' clinical and post-therapy pathological characteristics were analyzed...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27718753/proteomics-approach-to-identify-biomarkers-for-upper-gastrointestinal-cancer
#10
Kazuto Harada, Dilsa Mizrak Kaya, Yusuke Shimodaira, Shumei Song, Hideo Baba, Jaffer A Ajani
The prognosis for patients with upper gastrointestinal cancers remains dismal despite the development of multimodality therapies that incorporate surgery, chemotherapy, and radiotherapy. Early diagnosis and personalized treatment should lead to better prognosis. Given the advances in proteomic technologies over the past decades, proteomics promises to be the most effective technique to identify novel diagnostics and therapeutic targets. Areas covered: For this review, keywords were searched in combination with "proteomics" and "gastric cancer" or "esophageal cancer" in PubMed...
October 10, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27701375/intraoperative-radiotherapy-in-gastric-and-esophageal-cancer-meta-analysis-of-long-term-outcomes-and-complications
#11
Peng Gao, Chengche Tsai, Yuchong Yang, Yingying Xu, Changwang Zhang, Cong Zhang, Longyi Wang, Hongpeng Liu, Zhenning Wang
BACKGROUND: The treatment effects of intraoperative radiotherapy (IORT) for gastric and esophageal cancer remain uncertain. We therefore performed meta-analyses to investigate whether IORT was associated with more favorable oncologic outcomes when compared to non-IORT for patients who have gastric or esophageal cancer. METHODS: PubMed, Embase, and the references of relevant studies were systematically searched up to March 2016. Outcomes were analyzed with fixed-effect or random-effect models, and the meta-analysis was completed with odds ratio (OR), hazards ratio (HR), and 95% confidence intervals (CI) as effect values...
October 4, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27672720/experience-of-low-dose-short-course-palliative-radiotherapy-for-bleeding-from-unresectable-gastric-cancer
#12
Hideaki Kawabata, Koji Uno, Kenjiro Yasuda, Masato Yamashita
BACKGROUND/AIMS: The optimal regimen of radiotherapy (RT) for bleeding from gastric cancer (GC) has not yet been established. The aim of this study was to evaluate the usefulness of low-dose, short-course palliative RT (LSP-RT) for bleeding from GC. MATERIAL AND METHODS: We reviewed the clinical data of 18 patients (26 courses) who received palliative RT for bleeding from GC between 2004 and 2014. The radiation dose was 6 Gy in three fractions. The total courses of RT for each patient were 1-4 (median, 1)...
February 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27659357/usefulness-of-chemoradiotherapy-for-inoperable-gastric-cancer
#13
T Taki, Y Hoya, A Watanabe, T Nakayoshi, T Okamoto, H Sekine, N Mitsumori, K Yanaga
Introduction Radiotherapy is not commonly used for the treatment of gastric cancer in Japan, where surgery is the standard local treatment. We report the results of chemoradiotherapy in patients with advanced or recurrent gastric cancer which was deemed difficult to treat surgically. Methods Twenty-one patients with gastric cancer (including sixteen with advanced/recurrent gastric cancer and five with poor general condition) underwent chemo-radiotherapy, for whom the therapeutic efficacy, toxicity and survival period were analysed...
September 23, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27620279/characterization-of-biomarkers-of-tumorigenic-and-chemoresistant-cancer-stem-cells-in-human-gastric-carcinoma
#14
Phu Hung Nguyen, Julie Giraud, Lucie Chambonnier, Pierre Dubus, Linda Wittkop, Genevieve Belleannée, Denis Collet, Isabelle Soubeyran, Serge Evrard, Benoit Rousseau, Nathalie Dugot-Senant, Francis Mégraud, Frédéric Mazurier, Christine Varon
PURPOSE: Gastric carcinomas (GC) are heterogeneous, and the current therapy remains essentially based on surgery with conventional chemo- and radiotherapy. This study aimed to characterize biomarkers allowing the detection of cancer stem cells (CSC) in human GC of different histological types. EXPERIMENTAL DESIGN: The primary tumors from thirty-seven patients with intestinal or diffuse type non-cardia GC were studied, and patient's derived tumor xenograft (PDX) models in immunodeficient mice were developed...
September 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27614525/-the-dawn-of-radiotherapy-between-strokes-of-genius-dramas-and-controversies
#15
J-M Cosset
Radiotherapy is 120 years old. A few months only after the discoveries of Roentgen, Becquerel and Marie and Pierre Curie, a few scientists tried to use the newly discovered rays to treat patients. The question of the name of the first "radiation therapist" remains debated. Although often proposed, Emil Grubbé from Chicago seems to have been disqualified. Leopold Freund from Vienna treated a benign cutaneous lesion. Finally, Victor Despeignes from Lyon appears to be the most serious candidate, having treated in 1896 a gastric cancer, and obtaining a very significant tumour regression...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27601943/can-we-obtain-planning-goals-for-conformal-techniques-in-neoadjuvant-and-adjuvant-radiochemotherapy-for-gastric-cancer-patients
#16
Wojciech Leszczyński, Paweł Polanowski, Paulina Leszczyńska, Leszek Hawrylewicz, Iwona Brąclik, Rafał Kawczyński, Jerzy Wydmański
AIM: The purpose of this study was to compare conformal radiotherapy techniques used in the treatment of gastric cancer patients. The study is dedicated to radiotherapy centres that have not introduced dynamic techniques in clinical practice. BACKGROUND: The implementation of multi-field technique can minimise the toxicity of treatment and improve dose distribution homogeneity in the target volume with simultaneous protection of organs at risk (OaRs). Treatment plan should be personalised for each patient by taking into account the planning target volume and anatomical conditions of the individual patient...
May 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27563457/clinical-outcomes-and-toxicities-of-proton-radiotherapy-for-gastrointestinal-neoplasms-a-systematic-review
#17
Vivek Verma, Steven H Lin, Charles B Simone, Minesh P Mehta
BACKGROUND: Proton beam radiotherapy (PBT) is frequently shown to be dosimetrically superior to photon radiotherapy (RT), though supporting data for clinical benefit are severely limited. Because of the potential for toxicity reduction in gastrointestinal (GI) malignancies, we systematically reviewed the literature on clinical outcomes (survival/toxicity) of PBT. METHODS: A systematic search of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology was conducted for publications from 2000-2015...
August 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27543101/evaluation-the-survival-of-patients-with-gastric-cancer-treated-with-adjuvant-or-palliative-chemotherapy
#18
Mozaffar Aznab, Omid Beiki, Kiumars Eslam Pia, Khosro Setayeshi, Mohamad Ali Hesami, Houshang Vrae
AIM: Our aim was to evaluate impact of chemotherapy (5-fluorouracil plus docetaxel and cisplatin) on the survival of gastric cancer cases. METHOD: Seventy-nine patients were eligible to take part in this study between November 2006 and April 2013, who received 5-fluorouracil (700 mg/m(2), 21-h infusion within 5 days), cisplatin (60 mg/m(2) on day 3), and Docetaxel (60 mg/m(2) on day 2). Radiotherapy was added to the treatment only in the cases with entire stomach body cancer (positive margin) and with giant ulcer (above 50 mm) in proximal gastric cancer...
August 20, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27537382/role-of-histological-regression-grade-after-two-neoadjuvant-approaches-with-or-without-radiotherapy-in-locally-advanced-gastric-cancer
#19
Patricia Martin-Romano, Jose J Sola, Juan A Diaz-Gonzalez, Ana Chopitea, Yohana Iragorri, Fernando Martínez-Regueira, Mariano Ponz-Sarvise, Leire Arbea, Jose C Subtil, David Cano, Lucia Ceniceros, Jairo Legaspi, Jose Luis Hernandez, Javier Rodríguez
BACKGROUND: The degree of histopathological response after neoadjuvant therapy in locally advanced gastric cancer (GC) is a key determinant of patients' long-term outcome. We aimed to assess the pattern of histopathological regression after two neoadjuvant approaches and its impact on survival times. METHODS: Regression grade of the primary tumour (Becker criteria) and the degree of nodal response by a 4-point scale (grades A-D) were assessed. Grade A-true negative lymph nodes (LNs); grade B and C-infiltrated LNs with any or little evidence of nodal response; and grade D-complete pathological response in a previously infiltrated LN...
September 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27536175/regional-variation-in-the-management-of-metastatic-gastric-cancer-in-ontario
#20
A L Mahar, N G Coburn, D J Kagedan, R Viola, A P Johnson
BACKGROUND: Geographic variation in cancer care is common when clear clinical management guidelines do not exist. In the present study, we sought to describe health care resource consumption by patients with metastatic gastric cancer (gc) and to investigate the possibility of regional variation. METHODS: In this population-based cohort study of patients with stage iv gastric adenocarcinoma diagnosed between 1 April 2005 and 31 March 2008, chart review and administrative health care data were linked to study resource utilization outcomes (for example, clinical investigations, treatments) in the province of Ontario...
August 2016: Current Oncology
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