Hany H Arab, Ahmed H Eid, Rania Yahia, Shuruq E Alsufyani, Ahmed M Ashour, Azza A K El-Sheikh, Hany W Darwish, Muhammed A Saad, Muhammad Y Al-Shorbagy, Marwa A Masoud
Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, its effect on cadmium neurotoxicity remains to be investigated. In this study, topiramate was tested for its potential to combat the cognitive deficits induced by cadmium in rats with an emphasis on hippocampal oxidative insult, apoptosis, and autophagy...
August 29, 2023: Pharmaceuticals