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https://www.readbyqxmd.com/read/27998899/effect-of-the-type-of-maternal-pushing-during-the-second-stage-of-labour-on-obstetric-and-neonatal-outcome-a-multicentre-randomised-trial-the-eole-study-protocol
#1
Chloé Barasinski, Françoise Vendittelli
INTRODUCTION: The scientific data currently available do not allow any definitive conclusion to be reached about what type of pushing should be recommended to women during the second stage of labour. The objective of this trial is to assess and compare the effectiveness of directed open-glottis pushing versus directed closed-glottis pushing. Secondary objectives are to assess, according to the type of pushing: immediate maternal and neonatal morbidity, intermediate-term maternal pelvic floor morbidity, uncomplicated birth, and women's satisfaction at 4 weeks post partum...
December 20, 2016: BMJ Open
https://www.readbyqxmd.com/read/27925430/pulmonary-hypertension-as-estimated-by-doppler-echocardiography-in-adolescent-and-adult-patients-with-cystic-fibrosis-and-their-relationship-with-clinical-lung-function-and-sleep-findings
#2
Bruna Ziegler, Christiano Perin, Fernanda Cano Casarotto, Simone Chaves Fagondes, Sérgio Saldanha Menna-Barreto, Paulo de Tarso Roth Dalcin
BACKGROUND: In cystic fibrosis (CF) patients, end stage of pulmonary disease is characterized by pulmonary hypertension (PH), hypoxemia, decrease in exercise tolerance, and sleep quality. OBJECTIVE: To evaluate the association between clinical, lung function, sleep quality, and polysomnographic variables with PH in CF patients aged 16 years or older. METHODS: In a cross-sectional study, 51 clinically stable CF patients underwent a clinical evaluation, an overnight polysomnography and answered sleep questionnaires (Pittsburgh Sleep Quality Index and Epworth sleepiness scale)...
December 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27857839/fatal-outcome-in-a-hispanic-woman-with-moyamoya-syndrome-and-graves-disease
#3
Julian Choi, Perin Suthakar, Farbod Farmand
: We describe the case of a young Hispanic female who presented with thyrotoxicosis with seizures and ischemic stroke. She was diagnosed with a rare vasculopathy - moyamoya syndrome. After starting antithyroid therapy, her neurologic symptoms did not improve. Acute neurosurgical intervention had relieved her symptoms in the immediate post-operative period after re-anastomosis surgery. However, 2 post-operative days later, she was found to be in status epilepticus and in hyperthyroid state...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27754582/rapid-dipstick-detection-of-vibrio-cholerae-in-household-stored-and-municipal-water-in-dhaka-bangladesh-chobi7-trial
#4
Mahamud-Ur Rashid, Zillur Rahman, Vanessa Burrowes, Jamie Perin, Munshi Mustafiz, Shirajum Monira, K M Saif-Ur-Rahman, Sazzadul Islam Bhuyian, Md Toslim Mahmud, R Bradley Sack, David Sack, Munirul Alam, Christine Marie George
OBJECTIVE: In urban Dhaka, Bangladesh, 30% of source water samples collected from the households of patients with cholera had detectable Vibrio cholerae. These findings indicate an urgent need for a public health intervention for this population. The Crystal VC(®) dipstick test is a rapid method for detecting V. cholerae in stool and water. However, to date no study has investigated the use of the rapid dipstick test for household surveillance of stored drinking water. METHODS: The efficacy of the Crystal VC(®) dipstick test for detecting V...
October 18, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27753239/application-of-shear-wave-elastography-to-estimate-the-stiffness-of-the-male-striated-urethral-sphincter-during-voluntary-contractions
#5
Ryan E Stafford, Rafeef Aljuraifani, François Hug, Paul W Hodges
OBJECTIVES: To investigate whether increases in stiffness can be detected in the anatomical region associated with the striated urethral sphincter during voluntary activation using shear wave elastography; to identify the location and area of the stiffness increase relative to the point of greatest dorsal displacement of the mid urethra (i.e. striated urethral sphincter); and to determine the relationship between muscle stiffness and contraction intensity. SUBJECTS AND METHODS: Ten healthy men participated...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27749356/methods-of-pushing-during-vaginal-delivery-and-pelvic-floor-and-perineal-outcomes-a-review
#6
Renaud de Tayrac, Vincent Letouzey
PURPOSE OF REVIEW: Over the past 20 years, several randomized studies have compared Valsalva and spontaneous pushing techniques during vaginal delivery. This review summarizes current medical knowledge concerning their maternal and fetal consequences, focusing on pelvic and perineal outcomes. RECENT FINDINGS: We selected nine randomized controlled trials comparing Valsalva and spontaneous pushing, and a secondary analysis of a randomized controlled trial comparing different methods of perineal protection...
October 5, 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27717206/epigenetic-silencing-of-mir-200c-in-breast-cancer-is-associated-with-aggressiveness-and-is-modulated-by-zeb1
#7
Valentina Damiano, Giulia Brisotto, Silvia Borgna, Alessandra di Gennaro, Michela Armellin, Tiziana Perin, Michela Guardascione, Roberta Maestro, Manuela Santarosa
Loss of expression of miR-200 family members has been implicated in cellular plasticity, a phenomenon that accounts for epithelial-to-mesenchymal transition (EMT) and stem-like features of many carcinomas and is considered a major cause of tumor aggressiveness and drug resistance. Nevertheless, the mechanisms of miR-200 downregulation in breast cancer are still largely unknown. Here we show that miR-200c expression inversely correlates with miR-200c/miR-141 locus methylation in triple-negative breast tumors (TNBC)...
February 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27689055/three-directional-reconstruction-of-a-massive-perineal-defect-after-wide-local-excision-of-extramammary-paget-s-disease
#8
Seung Woo Cho, Hak Chang, Sung Tack Kwon
Extramammary Paget's disease (EMPD) is a rare, slow-growing intraepithelial malignancy that mainly involves the genital region, including the vulva, penis, scrotum, perianal, and periurethral areas. Although several treatment options exist, wide local excision with a safe margin is considered the treatment of choice. After resection of the lesion, it is often challenging to reconstruct the defect because defects in the perineal region require adequate volume for protection and are susceptible to infections, which is a particularly significant risk for large defects...
September 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27638252/streptococcus-pyogenes-as-the-cause-of-vulvovaginitis-and-balanitis-in-children
#9
Gordana Randjelovic, Suzana Otasevic, Snezana Mladenovic-Antic, Vesna Mladenovic, Radmila Radovanovic-Velickovic, Marina Randjelovic, Dragan Bogdanovic
BACKGROUND: Streptococcus pyogenes (group A Streptococcus) is the etiological agent of perineal infection in children, consisting of perianal infection, vulvovaginitis and balanitis. If it is not properly diagnosed and treated, it can persist for many months and can cause severe complications. Furthermore, treatment with penicillin can be followed by failures and recurrences. METHODS: We report here the prevalence of S. pyogenes isolates in genital tract specimens from girls (n = 1692) with symptoms of vulvovaginitis and from boys (n = 52) with balanitis in the municipality of Nis, Southeast-Serbia (the Western Balkans) in a 10 year period, and the seasonal distribution, patient age and sensitivity to bacitracin and antimicrobial drugs used in the treatment of streptococcal infection...
September 16, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27629783/repair-of-transperineal-recto-urethral-fistula-using-a-fibrin-sealant-haemostatic-patch
#10
Giuseppe Giuliani, Francesco Guerra, Diego Coletta, Marco La Torre, Giorgio Franco, Costantino Leonardo, Aldo Infantino, Filippo La Torre
AIM: Rectourethral fistula (RUF) is a rare complication of radical prostatectomy. We report a trans-perineal approach using a fibrin sealant haemostatic patch. METHOD: Five consecutive patients who developed RUF following radical prostatectomy had a direct transperineal repair with a haemostatic patch (TachoSil(®) ) and were assessed at a median follow up of 35.5 (21-45) months. RESULTS: There were no early postoperative complications. The average length of hospital stay was 5 (4-7) days...
September 15, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27622320/clonal-hematopoiesis-in-patients-with-dyskeratosis-congenita
#11
Nieves Perdigones, Juan C Perin, Irene Schiano, Peter Nicholas, Jaclyn A Biegel, Philip J Mason, Daria V Babushok, Monica Bessler
Dyskeratosis congenita (DC) is a rare inherited telomeropathy most frequently caused by mutations in a number of genes all thought to be involved in telomere maintenance. The main causes of mortality in DC are bone marrow failure as well as malignancies including leukemias and solid tumors. The clinical picture including the degree of bone marrow failure is highly variable and factors that contribute to this variability are poorly understood. Based on the recent finding of frequent clonal hematopoiesis in related bone marrow failure syndromes, we hypothesized that somatic mutations may also occur in DC and may contribute at least in part to the variability in blood production...
December 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27620339/double-barrelled-wet-colostomy-formation-after-pelvic-exenteration-for-locally-advanced-or-recurrent-rectal-cancer
#12
A L A Bloemendaal, R Kraus, N C Buchs, F C Hamdy, R Hompes, L Cogswell, R J Guy
AIM: In advanced pelvic cancer it may be necessary to perform a total pelvic exenteration. In such cases urinary tract reconstruction is usually achieved with the creation of an ileal conduit with a urinary stoma on the right side of the patient's abdomen and an end colostomy separately on the left. The potential morbidity from a second stoma may be avoided by the use of a double-barrelled wet colostomy (DBWC), as a single stoma. Another advantage is the possibility of using a vertical rectus abdominis muscle flap for perineal reconstruction...
November 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27614242/bifunctional-fluorescent-benzimidazo-1-2-%C3%AE-quinolines-for-candida-spp-biofilm-detection-and-biocidal-activity
#13
Igor O P de Souza, Clarissa M L Schrekker, William Lopes, Romano V A Orru, Marijana Hranjec, Nataša Perin, Michel Machado, Luís F Oliveira, Ricardo K Donato, Valter Stefani, Alexandre M Fuentefria, Henri S Schrekker
Biofilms provide an ideal environment for protecting the microbial cells from damage caused by humoral and cellular immune system components, promoting resistance, infections and increasing mortality and morbidity of patients in health facilities. In an attempt to provide an innovative solution for preventing contamination in hospital environments, this study evaluated nine structural complementary fluorescent benzimidazo[1,2-α]quinolines as bifunctional agents that both detect and have biocidal activity against yeast biofilms on stainless steel surfaces...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27591734/total-mesorectal-excision-for-cancer-histological-and-immunohistochemical-evidence-of-nerve-removal-and-risk-factor-analysis
#14
D Moszkowicz, G Rougier, C Julié, K Nyangoh Timoh, A Beauchet, K Vychnevskaia, R Malafosse, B Nordlinger, F Peschaud
AIM: Whether or not nerve-sparing rectal-cancer surgery can effectively prevent removal of the pelvic autonomic nerves has not been substantiated microscopically. We aimed to analyse the quality of nerve preservation in female patients by quantifying residual nerve fibres in total mesorectal excision specimens, to analyse pro-erectile function of the nerve fibres removed and to determine risk factors for pelvic denervation. METHOD: Serial transverse sections from female patients, 64 ± 18 years of age, were studied after the mesorectal fascia was inked and studied histologically [using anti-S100 and anti-neuronal nitric oxide synthase (nNOS) antibodies]...
October 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27565019/a-functional-and-clinical-reinterpretation-of-human-perineal-neuromuscular-anatomy-application-to-sexual-function-and-continence
#15
Jeffrey H Plochocki, Jose R Rodriguez-Sosa, Brent Adrian, Saul A Ruiz, Margaret I Hall
Modern anatomical and surgical references illustrate perineal muscles all innervated by branches of the pudendal nerve but still organized into anatomically distinct urogenital and anal triangles with muscles inserting onto a central perineal body. However, these conflict with the anatomy commonly encountered during dissection. We used dissections of 43 human cadavers to characterize the anatomical organization of the human perineum and compare our findings to standard references. We found bulbospongiosus and the superficial portion of the external anal sphincter (EAS) were continuous anatomically with a common innervation in 92...
November 2016: Clinical Anatomy
https://www.readbyqxmd.com/read/27548909/association-between-glycaemic-control-and-common-infections-in-people-with-type-2-diabetes-a-cohort-study
#16
J L Hine, S de Lusignan, D Burleigh, S Pathirannehelage, A McGovern, P Gatenby, S Jones, D Jiang, J Williams, A J Elliot, G E Smith, J Brownrigg, R Hinchcliffe, N Munro
AIM: To investigate the impact of glycaemic control on infection incidence in people with Type 2 diabetes. METHODS: We compared infection rates during 2014 in people with Type 2 diabetes and people without diabetes in a large primary care cohort in the UK (the Royal College of General Practitioners Research and Surveillance Centre database). We performed multilevel logistic regression to investigate the impact of Type 2 diabetes on presentation with infection, and the effect of glycaemic control on presentation with upper respiratory tract infections, bronchitis, influenza-like illness, pneumonia, intestinal infectious diseases, herpes simplex, skin and soft tissue infections, urinary tract infections, and genital and perineal infections...
August 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27447218/prevalence-and-risk-factors-associated-with-endoparasitosis-of-dogs-and-cats-in-esp%C3%A3-rito-santo-brazil
#17
Diefrey Ribeiro Campos, Luanna Castro Oliveira, Daniele Fassina de Siqueira, Lívia Reisen Perin, Nayara Camatta Campos, Karina Preising Aptekmann, Isabella Vilhena Freire Martins
The objective of this study was to determine the prevalence and risk factors for the occurrence of endoparasitosis in dogs and cats in Espírito Santo, Brazil. For the study, 345 dogs and 160 cats were examined. Faecal samples from the animals were collected, and owners were interviewed about their handling of their animals. For the diagnosis of the infections, the Willis-Molley, simple centrifugal flotation and formalin-ether sedimentation techniques were performed. The data found in the tests were tabulated and analysed with a chi-square test (p <0...
September 1, 2016: Acta Parasitologica
https://www.readbyqxmd.com/read/27439348/use-of-a-laparoscopic-specimen-retrieval-pouch-to-facilitate-removal-of-intact-or-fragmented-cystic-calculi-from-standing-sedated-horses-8-cases-2012-2015
#18
Scott A Katzman, Betsy Vaughan, Jorge E Nieto, Larry D Galuppo
OBJECTIVE To evaluate the use of a laparoscopic specimen retrieval pouch for removal of intact or fragmented cystic calculi from standing horses. DESIGN Retrospective case series. ANIMALS 8 horses (5 geldings and 3 mares) with cystic calculi. PROCEDURES Physical examination and cystoscopic, ultrasonographic, and hematologic evaluations of urinary tract function were performed for each horse. A diagnosis of cystic calculus was made on the basis of results of cystoscopy and ultrasonography. Concurrent urolithiasis or other urinary tract abnormalities identified during preoperative evaluation were recorded...
August 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27427829/a-novel-technique-of-introducing-the-mesh-at-the-distal-dissection-while-performing-laparoscopic-ventral-rectopexy
#19
A Tsunoda, T Takahashi, T Ohta, H Kusanagi
AIM: Laparoscopic ventral rectopexy (LVR) is considered an effective treatment for rectal prolapse and/or rectoanal intussusception. After the dissection of the rectovaginal septum down to the pelvic floor, a strip of mesh is introduced and should be secured as distally as possible. We have developed a novel technique of introducing the mesh at the distal dissection. METHOD: A nylon thread with straight needle was passed through the posterior wall of vagina at the distal extent of the dissection, which was caught in the abdominal cavity and fixed at the end of the mesh extracorporeally...
September 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27410172/robotic-perineal-radical-prostatectomy-and-pelvic-lymph-node-dissection-using-a-purpose-built-single-port-robotic-platform
#20
Daniel Ramirez, Matthew J Maurice, Jihad H Kaouk
OBJECTIVE: To describe the features of the novel, purpose-built da Vinci model SP1098 single-port (SP) robotic platform and describe a step-by-step approach for perineal prostatectomy and pelvic lymph node dissection in a cadaver model. METHODS: 3 SP robotic radical perineal prostatectomies and 2 pelvic lymph node dissections were performed on 3 male cadavers in order to assess the feasibility of the SP1098 da Vinci robotic platform. The steps of the procedure included division of the rectourethralis muscle, splitting of the levator ani muscles bilaterally, opening of Denonvilliers fascia with dissection of the seminal vesicles, apical dissection and urethral division, anterior and lateral dissection with ligation of prostatic pedicles, bilateral pelvic lymph node dissection, and creation of the new vesicourethral anastomosis...
July 13, 2016: BJU International
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