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Life style disease

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https://www.readbyqxmd.com/read/29677973/yorwalk-desiging-a-smartphone-exercise-application-for-people-with-intermittent-claudication
#1
Ahmed Shalan, Abubakar Abdulrahman, Ibrahim Habli, Garry Tew, Andrew Thompson
Peripheral Arterial Disease (PAD) is a chronic cardiovascular disease. It is highly prevalent in older adults. Mobile Health (mHealth) and Telehealth technologies are considered two central digital solutions for enabling patient-centred care. There is evidence that physical activity apps can improve health outcomes in adults. The aim of this project is to develop a prototype of smart phone app to target patients with PAD, which we named YORwalK, to promote exercise and track changes in walking ability in this population...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677102/implications-of-pi3k-akt-pten-signaling-on-superoxide-dismutases-expression-and-in-the-pathogenesis-of-alzheimer-s-disease
#2
REVIEW
Satoru Matsuda, Yukie Nakagawa, Ai Tsuji, Yasuko Kitagishi, Atsuko Nakanishi, Toshiyuki Murai
Alzheimer’s disease is a neurodegenerative sickness, where the speed of personal disease progression differs prominently due to genetic and environmental factors such as life style. Alzheimer’s disease is described by the construction of neuronal plaques and neurofibrillary tangles composed of phosphorylated tau protein. Mitochondrial dysfunction may be a noticeable feature of Alzheimer’s disease and increased production of reactive oxygen species has long been described. Superoxide dismutases (SODs) protect from excess reactive oxygen species to form less reactive hydrogen peroxide...
April 20, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29666919/prevalence-of-vitamin-d-insufficiency-and-evidence-for-disease-prevention-in-the-older-population
#3
REVIEW
Julia Kühn, Paula Trotz, Gabriele I Stangl
The prevalence of vitamin D insufficiency, usually assessed by the analysis of circulating 25-hydroxyvitamin D (25[OH])D), is very high in the aging German population. An important factor that reduces endogenous vitamin D synthesis in older persons is physical inactivity or care-dependency that limits the time spent outside. Additionally, it has been suggested that the age-dependent decline in the glomerular filtration rate is associated with a reduced production of bioactive calcitriol. As this phenomenon is not detectable by the assessment of 25(OH)D, it is necessary to analyze the level of parathyroid hormone as a marker of calcitriol function...
April 17, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29664428/-case-report-and-the-surgical-treatment-of-two-cases-with-pulmonary-atresia-in-which-pulmonary-arteries-is-circulated-by-coronary-arteries
#4
Kahraman Yakut, Kürşad Tokel, Birgül Varan, İlkay Erdoğan, Murat Özkan
Pulmonary atresia (PA) and ventricular septal defect (VSD) can occur in a variety of ways, from simple valve atresia to a condition in which circulation to the pulmonary bed occurs through collateral arteries separated from the aorta and there are no real pulmonary arteries, or they are present but hypoplastic. The size of the pulmonary arteries and concomitant complex cardiac lesions are important in making decisions about treatment and correctional alternatives. While complete correction surgeries in the style of a correction of tetralogy of Fallot are performed in simpler cases, many very invasive procedures are also performed and the resulting quality of life is very variable...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29618986/the-antioxidant-therapy-new-insights-in-the-treatment-of-hypertension
#5
REVIEW
Daniela Sorriento, Nicola De Luca, Bruno Trimarco, Guido Iaccarino
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a key role in the regulation of the physiological and pathological signaling within the vasculature. In physiological conditions, a delicate balance between oxidants and antioxidants protects cells from the detrimental effects of ROS/RNS. Indeed, the imbalance between ROS/RNS production and antioxidant defense mechanisms leads to oxidative and nitrosative stress within the cell. These processes promote the vascular damage observed in chronic conditions, such as hypertension...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29615959/rorschach-evaluation-of-personality-and-emotional-characteristics-in-adolescents-with-migraine-versus-epilepsy-and-controls
#6
Laura Balottin, Stefania Mannarini, Daniela Candeloro, Alda Mita, Matteo Chiappedi, Umberto Balottin
The literature examining primary headache, including migraine, in adolescents, has pointed out the key role played by a wide range of psychiatric disorders in reducing the patients' quality of life. Moreover, pioneering studies showed that preexisting personality characteristics, specific emotion regulation styles and psychological-psychiatric difficulties are likely to increase the risk of the onset, maintenance, and outcome of headache. Still personality issues in migraine have been poorly studied, in particular in children and adolescents...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29610551/numerical-analyses-of-intestinal-microbiota-by-data-mining
#7
REVIEW
Toshio Kobayashi, Akira Andoh
The human intestinal microbiota has a close relationship with health control and causes of diseases, and a vast number of scientific papers on this topic have been published recently. Some progress has been made in identifying the causes or species of related microbiota, and successful results of data mining are reviewed here. Humans who are targets of a disease have their own individual characteristics, including various types of noise because of their individual life style and history. The quantitatively dominant bacterial species are not always deeply connected with a target disease...
March 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29610110/counting-steps-in-activities-of-daily-living-in-people-with-a-chronic-disease-using-nine-commercially-available-fitness-trackers-cross-sectional-validity-study
#8
Darcy Ummels, Emmylou Beekman, Kyra Theunissen, Susy Braun, Anna J Beurskens
BACKGROUND: Measuring physical activity with commercially available activity trackers is gaining popularity. People with a chronic disease can especially benefit from knowledge about their physical activity pattern in everyday life since sufficient physical activity can contribute to wellbeing and quality of life. However, no validity data are available for this population during activities of daily living. OBJECTIVE: The aim of this study was to investigate the validity of 9 commercially available activity trackers for measuring step count during activities of daily living in people with a chronic disease receiving physiotherapy...
April 2, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29606258/treatment-of-iga-nephropathy-recent-advances-and-prospects
#9
REVIEW
Rosanna Coppo
IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease worldwide. The course is variable, but in most of the cases there is a relentless decline in renal function, reaching end-stage renal failure in 10-60% of the cases after 10 years and in 40% after 20 years. These data justify the interest for finding a suitable therapeutic approach particularly in progressive cases. A supportive care, including renin-angiotensin system inhibitors is the priority in cases with slowly declining renal function, particularly when developing proteinuria...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29601825/identification-of-endpoints-for-development-of-anti-fibrosis-drugs-for-treatment-of-crohn-s-disease
#10
Silvio Danese, Stefanos Bonovas, Anthony Lopez, Gionata Fiorino, William J Sandborn, David T Rubin, Michael A Kamm, Jean-Frederic Colombel, Bruce E Sands, Severine Vermeire, Julian Panes, Gerhard Rogler, Geert D'Haens, Laurent Peyrin-Biroulet
BACKGROUND & AIMS: Intestinal fibrosis is a challenge to management of patients with Crohn's disease (CD); there is an urgent need to expedite development of anti-fibrosis drugs for this disease. The International Organization for the Study of Inflammatory Bowel Disease (IOIBD) aimed to identify a set of endpoints that can be used to determine efficacy of anti-fibrosis agents tested in clinical trials of patients with CD. METHODS: We conducted a systematic review to identify clinical, radiologic, biochemical, endoscopic, and composite endpoints used in assessing activity of fibrostenosing CD and response to treatment, and determined their operational properties...
March 27, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29594339/obesogenic-habits-among-children-and-their-families-in-response-to-initiation-of-gluten-free-diet
#11
Neriya Levran, Michael Wilschanski, Jessica Livovsky, Edna Shachar, Moti Moskovitz, Lama Assaf-Jabrin, Eyal Shteyer
Initiation of a lifelong, gluten-free diet (GFD) in children with celiac disease (CD) influences the child's life in many ways. The aim of this study was to assess the influence of GFD on the child and his/her family's eating habits and lifestyle behaviors. To study this, we asked children and their parents completed the Family Eating and Activity Habits Questionnaire (FEAHQ) at the time of diagnosis of CD and at least 6 months after initiation of GFD and a questionnaires assessing symptoms related to CD and adherence to the GFD diet...
March 29, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29570031/maternal-grief-a-qualitative-investigation-of-mothers-responses-to-the-death-of-a-child-from-cancer
#12
Nick J Gerrish, Susan Bailey
This study explored bereaved mothers' responses to the death of a child from cancer, with a focus on identifying adaptive and complicated grief reactions. To understand the unique meaning of their loss, in-depth interviews were conducted with 13 mothers at two time points. Interpretative phenomenological analysis-guided by meaning-making theories of loss-revealed five master categories: the perceptions of the child's life with cancer and death from the disease, changed self-identity, coping style, developing an ongoing relationship to the deceased child, and the postdeath social environment...
January 1, 2018: Omega
https://www.readbyqxmd.com/read/29560499/-epigenetics-important-aspects-for-anesthesiologists-pain-and-intensive-care-physicians
#13
REVIEW
A-K Reinhold, E Jentho, S T Schäfer, M Bauer, H L Rittner
Epigenetics, i.e. an altered reading of the genome without altering the genes themselves is a growing scientific field. A distinction is made between changes in the DNA by modification of the histones and non-coding RNA that alter the messenger (m)RNAs. Epigenetic modifications can be triggered by personal circumstances or other external factors and therefore influence the occurrence of diseases. Epigenetics are therefore of particular interest to anesthesiologists, pain specialists and intensive care physicians, as anesthetic drugs may have a long-term influence on protein transcription leading for example to alterations in neurocognition after anesthesia, chronification of postoperative pain and immune response in sepsis...
March 20, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29559129/teaching-parasitology-in-a-modular-veterinary-curriculum-the-vienna-experience
#14
Anja Joachim, Barbara Hinney, Georg Duscher, Ingrid Preusche, Petra Winter
In a changing world with rapidly evolving new technologies, even in the "sheltered world" of teachers and lecturers at universities, we are challenged by new developments. As diversification is increasing in many aspects of our professional life, there is also a need to employ new ways of teaching, learning and assessments in veterinary curricula, taking into account the increasing numbers of students and limited teaching resources. The "classical" Austrian veterinary curriculum, with a series of consecutive lectures followed by practical courses in the different disciplines, separated from each other in the curricular time table and by annual examinations, has been a long-standing concept for teaching in the past...
March 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29558823/corrigendum
#15
(no author information available yet)
Imai H, Furukawa TA, Hayashi SU, et al. (2017) Risk perception, self-efficacy, trust for physician, depression, and behavior modification in diabetic patients. Journal of Health Psychology. E pub ahead of print 7 July 2017. DOI: 10.1177/1359105317718057. The author omitted to include one of the funders in the Funding statement. The online version of this article has been corrected. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the Japan Agency for Medical Research and Development (Practical Research Project for Life-Style related Diseases including CVD and Diabetes), the Ministry of Health, Labour and Welfare of Japan (Strategic Outcomes Research Program for Research on Diabetes; Comprehensive Research on Life-Style Related Diseases including CVD and Diabetes H25-016), JSPS KAKENHI under Grant No...
March 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29555941/iso-%C3%AE-acids-bitter-components-of-beer-prevent-obesity-induced-cognitive-decline
#16
Tatsuhiro Ayabe, Rena Ohya, Keiji Kondo, Yasuhisa Ano
Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-α-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor γ. In this report, we demonstrated that daily intake of iso-α-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD)...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29555310/bone-histomorphometry-in-transiliac-biopsies-from-48-normal-healthy-men
#17
Robert R Recker, Mohammed K Akhter, Joan M Lappe, Patrice Watson
Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has not been adequate to date. The objective of this work is to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 48 healthy males, evenly distributed between ages 45 and 75...
March 16, 2018: Bone
https://www.readbyqxmd.com/read/29553077/-daily-life-style-and-psoriasis
#18
Yu Sawada, Motonobu Nakamura
Skin is an important organ that is located on the outermost layer of the human body, and serves as a defense barrier against external stimulation. Daily life style, including diet, exercise, and sleep, is a fundamental behavior of humans, and it has recently been reported that daily life style has a strong relationship with the inflammatory condition of skin diseases. This relationship has been examined by various approaches, including epidemiological investigations. Psoriasis is one inflammatory skin disease and is especially closely related with daily life style, such as diet, sleep, smoking and alcohol consumption...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29551995/genome-wide-analysis-of-corynespora-cassiicola-leaf-fall-disease-putative-effectors
#19
David Lopez, Sébastien Ribeiro, Philippe Label, Boris Fumanal, Jean-Stéphane Venisse, Annegret Kohler, Ricardo R de Oliveira, Kurt Labutti, Anna Lipzen, Kathleen Lail, Diane Bauer, Robin A Ohm, Kerrie W Barry, Joseph Spatafora, Igor V Grigoriev, Francis M Martin, Valérie Pujade-Renaud
Corynespora cassiicola is an Ascomycetes fungus with a broad host range and diverse life styles. Mostly known as a necrotrophic plant pathogen, it has also been associated with rare cases of human infection. In the rubber tree, this fungus causes the Corynespora leaf fall (CLF) disease, which increasingly affects natural rubber production in Asia and Africa. It has also been found as an endophyte in South American rubber plantations where no CLF outbreak has yet occurred. The C. cassiicola species is genetically highly diverse, but no clear relationship has been evidenced between phylogenetic lineage and pathogenicity...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29551255/sex-steroids-sex-hormone-binding-globulin-and-levels-of-n-terminal-pro-brain-natriuretic-peptide-in-postmenopausal-women
#20
Marija Glisic, Lyda Z Rojas, Eralda Asllanaj, Kris G Vargas, Maryam Kavousi, M Arfan Ikram, Bart C J M Fauser, Joop S E Laven, Taulant Muka, Oscar H Franco
BACKGROUND: Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) has a well-documented prognostic value for cardiovascular disease and sex-hormones are suggested to modulate NT-proBNP levels. OBJECTIVE: To examine whether endogenous sex-hormones and sex hormone-binding globulin (SHBG) are associated with NT-proBNP levels in postmenopausal women free of clinical cardiovascular diseases. METHODS: Total estradiol (E2 ), total testosterone (TT), androstenedione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and NT-proBNP were assessed in 4112 postmenopausal women free of cardiovascular diseases from the prospective population-based Rotterdam Study...
March 6, 2018: International Journal of Cardiology
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