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https://www.readbyqxmd.com/read/29222911/current-and-future-therapeutic-regimens-for-non-alcoholic-fatty-liver-disease-nafld-and-non-alcoholic-steatohepatitis-nash
#1
REVIEW
Zobair M Younossi, Rohit Loomba, Mary E Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A Neuschwander-Tetri, Lawrence Serfaty, Francesco Negro, Stephen H Caldwell, Vlad Ratziu, Kathleen E Corey, Scott L Friedman, Manal F Abdelmalek, Stephen A Harrison, Arun J Sanyal, Joel E Lavine, Philippe Mathurin, Michael R Charlton, Naga P Chalasani, Quentin M Anstee, Kris V Kowdley, Jacob George, Zachary D Goodman, Keith Lindor
NASH/NAFLD is rapidly becoming one of top causes of cirrhosis, hepatocellular carcinoma and indication for liver transplantation. Except for life style modification through diet and exercise, there are currently no other approved treatments for NASH/NAFLD. Although weight loss can be effective, it is hard to achieve and sustain. In contrast, bariatric surgery can improve metabolic conditions associated with NAFLD and has been shown to improve liver histology. In order to have approved regimens for treatment of NASH/NAFLD, a number of issues that must be addressed...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29218067/perceived-age-and-life-style-the-specific-contributions-of-seven-factors-involved-in-health-and-beauty
#2
Victor Gabriel Clatici, Daniel Racoceanu, Claude Dalle, Cristiana Voicu, Lucia Tomas-Aragones, Servando E Marron, Uwe Wollina, Simona Fica
OBJECTIVES: The skin is a dynamic, visible organ, showing the most obvious signs of aging. The mechanisms of extrinsic aging, most of them presented in this paper, are currently well known and also the only ones that can be counteracted. Therefore, the transition of this knowledge in the general population is of the most importance, in order to introduce healthy aging strategies, to prevent the development of chronic or malignant diseases and psychological burden related to old age. MATERIALS AND METHODS: A thorough review of the literature has been performed in order to identify the main factors involved in skin health and aging...
September 2017: Mædica
https://www.readbyqxmd.com/read/29209775/effect-of-aggressive-lipid-lowering-treatment-with-rosuvastatin-on-vascular-endothelium-function-evaluation-of-vascular-endothelium-function-earth-study
#3
Tadateru Takayama, Takafumi Hiro, Shunichi Yoda, Daisuke Fukamachi, Hironori Haruta, Takaaki Kogo, Takashi Mineki, Hironobu Murata, Toru Oshima, Atsushi Hirayama
Vascular endothelial dysfunction plays an important role in the process of atherosclerosis up to the final stage of plaque rupture. Vascular endothelial dysfunction is reversible, and can be recovered by medications and life-style changes. Improvement in endothelial function may reduce cardiovascular events and improve long-term prognosis. A total of 50 patients with stable angina and dyslipidemia were enrolled, including patients who had not received prior treatment with statins and had serum LDL-C levels ≥ 100 mg/dL, and patients who had previously received statin treatment...
December 5, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29204050/current-and-emerging-pharmacological-therapy-for-non-alcoholic-fatty-liver-disease
#4
EDITORIAL
Ahad Eshraghian
The main treatment of patients with non-alcoholic fatty liver disease (NAFLD) is life style modification including weight reduction and dietary regimen. Majority of patients are safely treated with this management and pharmacologic interventions are not recommended. However, a subgroup of NAFLD patients with non-alcoholic steatohepatitis (NASH) who cannot achieve goals of life style modification may need pharmacological therapy. One major obstacle is measurement of histological outcome by liver biopsy which is an invasive method and is not recommended routinely in these patients...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29199406/the-role-of-negative-affect-in-the-assessment-of-quality-of-life-among-women-with-type-1-diabetes-mellitus
#5
Nicola R Gawlik, Malcolm J Bond
BACKGROUND: The purpose of this study is to determine the impact of negative affect (defined in terms of lack of optimism, depressogenic attributional style, and hopelessness depression) on the quality of life of women with type 1 diabetes mellitus. METHODS: Participants (n=177) completed either an online or paper questionnaire made available to members of Australian diabetes support groups. Measures of optimism, attributional style, hopelessness depression, disease-specific data, and diabetes-related quality of life were sought...
November 7, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29197198/cardiovascular-disease-risk-factors-in-patients-with-posttraumatic-stress-disorder-ptsd-a-narrative-review
#6
Marina Šagud, Nenad Jakšić, Bjanka Vuksan-Ćusa, Mladen Lončar, Ivana Lončar, Alma Mihaljević Peleš, Davor Miličić, Miro Jakovljević
Posttraumatic stress disorder (PTSD) is a chronic condition related to severe stress and trauma. There is a mounting evidence about increased prevalence and mortality from cardiovascular diseases (CVD) in patients with PTSD. This review summarizes the current data on possible relations between PTSD and increased risks of CVD, including biological, psychological and behavioral factors. Biological factors refer to increased prevalence of metabolic syndrome (MetS), hypertension, elevation of pro-inflammatory cytokines and homocysteine levels...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29195308/oscillatory-dynamics-of-an-intravenous-glucose-tolerance-test-model-with-delay-interval
#7
Xiangyun Shi, Yang Kuang, Athena Makroglou, Sriprakash Mokshagundam, Jiaxu Li
Type 2 diabetes mellitus (T2DM) has become prevalent pandemic disease in view of the modern life style. Both diabetic population and health expenses grow rapidly according to American Diabetes Association. Detecting the potential onset of T2DM is an essential focal point in the research of diabetes mellitus. The intravenous glucose tolerance test (IVGTT) is an effective protocol to determine the insulin sensitivity, glucose effectiveness, and pancreatic β-cell functionality, through the analysis and parameter estimation of a proper differential equation model...
November 2017: Chaos
https://www.readbyqxmd.com/read/29191562/genetic-and-lifestyle-dependent-dental-caries-defined-by-the-acidic-proline-rich-protein-genes-prh1-and-prh2
#8
Nicklas Strömberg, Anders Esberg, Nongfei Sheng, Lena Mårell, Anna Löfgren-Burström, Karin Danielsson, Carina Källestål
Dental caries is a chronic infectious disease that affects billions of people with large individual differences in activity. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries. PRH1 and PRH2 variation and adhesion of indigenous and cariogenic (Streptococcus mutans) model bacteria were measured in 452 12-year-old Swedish children along with traditional risk factors and related to caries at baseline and after 5-years...
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29188861/antioxidants-in-the-diet-and-cognitive-function-which-role-for-the-mediterranean-life-style
#9
C Vassalle, L Sabatino, A Pingitore, K Chatzianagnostou, F Mastorci, R Ceravolo
This review aims to focus on main antioxidants- abundantly contained in the diet- as well as of the whole Mediterranean diet and life-style and their relationship with cognitive function, especially critical in two phases of life, in children until adolescence and oldness. The role of emerging biochemical and molecular biomarkers as opportunity to estimate more accurately nutritional assumption and requirement, in terms of cognitive preservation and disease risk, will be also discussed. The cluster of factors within the Mediterranean pattern -which include not only nutritional, but also physical, social, and stimulating aspects- is still largely understudied as a whole, but it is proposed as attractive research area and tool for public health planning of prevention and intervention...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29180045/unraveling-the-human-protein-atlas-of-metastatic-melanoma-in-the-course-of-ultraviolet-radiation-derived-photo-therapy
#10
Eumorphia G Konstantakou, Athanassios D Velentzas, Athanasios K Anagnostopoulos, Aikaterini F Giannopoulou, Ema Anastasiadou, Issidora S Papassideri, Gerassimos E Voutsinas, George Th Tsangaris, Dimitrios J Stravopodis
To explore the photo-therapeutic capacity of UV radiation in solid tumors, we herein employed an nLC-MS/MS technology to profile the proteomic landscape of irradiated WM-266-4 human metastatic-melanoma cells. Obtained data resulted in proteomic catalogues of 5982 and 7280 proteins for UVB- and UVC-radiation conditions, respectively, and indicated the ability of UVB/C-radiation forms to eliminate metastatic-melanoma cells through induction of synergistically operating programs of apoptosis and necroptosis. However, it seems that one or more WM-266-4 cell sub-populations may escape from UV-radiation's photo-damaging activity, acquiring, besides apoptosis tolerance, an EMT phenotype that likely offers them the advantage of developing resistance to certain chemotherapeutic drugs...
November 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29167167/cellular-mechanisms-underlying-obesity-induced-arterial-stiffness
#11
Annayya R Aroor, Guanghong Jia, James R Sowers
Obesity is an emerging pandemic driven by consumption of a diet rich in high fat and high refined carbohydrates (western diet [WD]) and a sedentary life style in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of adverse cardiovascular disease (CVD), cognitive functional decline and chronic kidney disease. Cardiovascular stiffness is a precursor to systolic hypertension, cardiac diastolic dysfunction, impairment of coronary and cerebral blood flow, and atherosclerosis...
November 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#12
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29156642/is-the-benefit-risk-ratio-for-patients-with-transfusion-dependent-thalassemia-treated-by-unrelated-cord-blood-transplantation-favorable
#13
REVIEW
Tang-Her Jaing
Transfusion-dependent thalassemia (TDT) is an inherited disorder characterized by absent or defective production of α- or β-hemoglobin chains. If untreated, the disease invariably culminates in death in early infancy due to cardiac failure or overwhelming infection. Although there is clear evidence of good health-related quality of life and return to normal life style, the choice to undergo hematopoietic stem cell transplantation (HSCT) remains a challenge because of the potential risk of transplant-related mortality (TRM) in TDT...
November 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29154966/determinants-of-fibrosis-progression-and-regression-in-nash
#14
REVIEW
Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang
Cirrhosis has become the major liver related clinical endpoint in nonalcoholic steatohepatitis. However, progression to cirrhosis is less predictable in NASH compared to other chronic liver diseases. This is due to the complex and multifactorial etiology of NASH, which is determined by life style and nutrition, multiple genetic and epigenetic factors, and a prominent role of hepatic and extrahepatic comorbidities. Thus modest changes in these cofactors can also induce fibrosis regression, at least in precirrhotic patients...
November 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29151393/ethics-of-smart-house-welfare-technology-for-older-adults-a-systematic-literature-review
#15
Veralia Gabriela Sánchez, Ingrid Taylor, Pia Cecilie Bing-Jonsson
BACKGROUND: The University College of Southeast Norway has an on-going project to develop a smart house welfare system to allow older adults and people with disabilities to remain in their homes for as long as they wish in safe, dignified, living conditions. OBJECTIVES: This article reviews reported ethical challenges to implementing smart houses for older adults. METHODS: A systematic literature review identified twenty-four articles in English, French, Spanish, and Norwegian, which were analyzed and synthesized using Hofmann's question list to investigate the reported ethical challenges...
November 20, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29144513/predictors-of-heart-rhythm-disturbances-in-hypertensive-obese-patients-with-obstructive-sleep-apnea
#16
Lyudmila Sergeevna Korostovtseva, Nadezhda Edvinovna Zvartau, Oxana Petrovna Rotar, Yurii Vladimirovich Sviryaev, Aleksandra Olegovna Konradi
Objective: To assess the incidence and predictors of heart rhythm and conduction disturbances in hypertensive obese patients with and without obstructive sleep apnea (OSA). Methods: This is an open, cohort, prospective study. Out of 493 screened patients, we selected 279 hypertensive, obese individuals without severe concomitant diseases: 75 patients without sleep-disordered breathing (non-SDB group), and 204 patients with OSA (OSA group). At baseline, all patients underwent examination, including ECG, Holter ECG monitoring, and sleep study...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29144382/treatment-approaches-to-moderate-to-severe-psoriasis
#17
REVIEW
Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Psoriasis is a common disease, which has a considerable impact on patients and the health care system. Treatment approaches to the disease may be various because some issues are not definitely addressed. Moreover, the therapeutic paradigms are continuously changing because of the recent approval of new treatments for psoriasis such as interleukin (IL)-17 inhibitors and apremilast. In this review, the factors influencing psoriasis severity, the indications for systemic treatments, the overall parameters to be considered in the treatment choice, life style interventions, and the recommendations for the use, screening, and monitoring of systemic therapies available including acitretin, cyclosporine, methotrexate, apremilast, adalimumab, etanercept, infliximab, secukinumab, ixekizumab, and ustekinumab are discussed...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29143687/prevalence-and-epidemiology-of-canine-and-feline-heartworm-infection-in-taiwan
#18
Ta-Li Lu, Jun-Yue Wong, Ta-Lun Tan, Yong-Wei Hung
BACKGROUND: Heartworm, Dirofilaria immitis, has long been recognized in Taiwanese dogs but feline heartworm infection has been largely overlooked by veterinarians and pet owners. The main goal of this study was to determine the prevalence and epidemiology of canine and feline heartworm infection in Taiwan. METHODS: Household dogs and cats were selected from 103 veterinary hospitals in 13 cities throughout Taiwan. All animals were at least 1 year old, had received no heartworm prevention for more than 1 year, and had lived in the same city for at least 1 year...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29139513/current-knowledge-of-intestinal-absorption-of-bioactive-peptides
#19
REVIEW
Weilin Shen, Toshiro Matsui
Peptides have been demonstrated as potentially beneficial compounds against several life-style related diseases such as hypertension, hypercholesterolemia, and atherosclerosis, among others. However, limited research has been carried out on peptide absorption, resulting in a lack of understanding and control of this process. Therefore, this review discusses the recent insights gathered on in vitro and in vivo absorption of peptides across intestinal membranes, into blood circulation. Briefly, some di-/tripeptides permeate through intestinal membranes in their intact forms via peptide transporter systems, while others are vulnerable to protease degradation...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29139339/high-prevalence-of-hypertension-and-its-selected-risk-factors-among-adult-tribal-population-in-central-india
#20
Tapas Chakma, Arvind Kavishwar, Ravendra K Sharma, P Vinay Rao
A community based cross-sectional study was carried out to assess the prevalence of hypertension and associated risk factors like salt intake, 24-h urinary sodium excretion and body mass index (BMI) among tribal population of Mandla District, Central India. A total of 3090 individuals, from 1258 house hold drawn from 33 sampled villages and 12 urban wards were studied for blood pressure measurements and clinical examination, while 414 urine samples were collected for estimation of 24-h sodium excretion. Bivariate and multivariate logistic regression were used to assess the associations of BMI, urinary sodium output and other risk factors with hypertension...
October 2017: Pathogens and Global Health
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