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Life style disease

Ichiro Tatsuno
No abstract text is available yet for this article.
October 18, 2016: Journal of Atherosclerosis and Thrombosis
Rajkumar Bharatia, Manoj Chitale, Ganesh Narain Saxena, Raman Ganesh Kumar, Chikkalingaiah, Abhijit Trailokya, Kalpesh Dalvi, Suhas Talele
INTRODUCTION: Hypertension (HTN), being a major risk factor for cardiovascular diseases (CVDs), is an important issue of medical and public health. High blood pressure (BP) is ranked as the third most important risk factor for attributable burden of disease in south Asia (2010). Hypertension (HTN) exerts a substantial public health burden on cardiovascular health status and healthcare systems in India. Uncontrolled hypertension among adults with hypertension is associated with increased mortality...
July 2016: Journal of the Association of Physicians of India
Jan Hansen, Silvie Timmers, Esther Moonen-Kornips, Helene Duez, Bart Staels, Matthijs K C Hesselink, Patrick Schrauwen
Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here we used human primary myotubes (HPM) to investigate if rhythmicity of clock- and metabolic gene expression is altered in donors with obesity or type 2 diabetes compared to metabolically healthy donors...
October 19, 2016: Scientific Reports
Yutaka Imai
It has been confirmed that clinical significance of home blood pressure measurements (HBPM) is higher than clinic BP measurements and ambulatory BP monitoring. However, several drawbacks of HBPM have also been mentioned, e.g. selection and reporting biases, difficulties of calculation of multiple measurements, difficulties of onsite judgement of numerous recordings, etc. Recent devices for HBPM incorporate memory function. This function can overcome such drawbacks of HBPM. These memorized data can transmit, storage, retrieve, be arithmetic and control, be judged based on algorithm and be got feedback...
September 2016: Journal of Hypertension
Rakesh Sharma
OBJECTIVE: ·MADTP 2015 may suggest diet, exercise, behavior and positive attitude to bring normal blood lipid levels in reducing risk of cardiovascular disease among middle aged persons.LONGLIVE LIFESTYLE cholesterol lowering program may reduce risk of cardiovascular disease by diet, six month exercise prescription and modified habits of smoking, alcohol and behavior DESIGN AND METHOD:: LONGLIVE LIFESTYLE diet plan along with walking-running exercise and behavior for six months was tested to improve serum high density lipoprotein cholesterol (HDL-C) appeared earliest; and the improvement of low density lipoprotein IV; cholesterol (LDL-C)...
September 2016: Journal of Hypertension
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
Jeong Bae Park
Blood pressure fluctuates beat to beat, minute to minute, day and night, day by day and even over longer period. However, changes in blood pressure (BP) itself reflect body's ability to adapt. These fluctuation or variability makes it difficult to diagnose and treat hypertension. And therefore, even though the clinic BP was the standard of BP for more than 100 years, there were many attempts to find other BP effects which influence on prognosis independent from clinical BP since there was the breakout of white coat effect and masked effect in clinic BP...
September 2016: Journal of Hypertension
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
Christina Brandenberger, Christian Mühlfeld
Lung aging is associated with structural remodeling, a decline of respiratory function and a higher susceptibility to acute and chronic lung diseases. Individual factors that modulate pulmonary aging include basic genetic configuration, environmental exposure, life-style and biography of systemic diseases. However, the actual aging of the lung takes place in pulmonary resident cells and is closely linked to aging of the immune system (immunosenescence). Therefore, this article reviews the current knowledge about the impact of aging on pulmonary cells and the immune system, without analyzing those factors that may accelerate the aging process in depth...
October 14, 2016: Cell and Tissue Research
Rosa Zampino, Caterina Sagnelli, Adriana Boemio, Evangelista Sagnelli, Nicola Coppola
 Due to virological, host and socio-economic factors, the clinical presentation and treatment of chronic hepatitis B (CHB) differs between developing and developed countries and may differ between one low-income country and another. National healthcare prevention and treatment policies, environmental factors, social habits and personal life-styles all influence HBV transmission and the clinical management and therapy of CHB. These factors can have a strong impact on the natural history of the disease and on Access to treatment and may eventually determine substantial changes in disease progression and the development of serious complications and hepatocellular carcinoma...
November 2016: Annals of Hepatology
Naresh Malhotra, M K Keshan, Avinash Agarwal, R Anil Kumar, Abhijit Trailokya, Kalpesh Dalvi, Suhas Talele
BACKGROUND: Cardiovascular diseases (CVD's) are the major cause of morbidity and mortality in both developed and developing countries. Many clinical trials have demonstrated that low-density lipoprotein cholesterol (LDL-C) lowering, reduces the incidence of coronary and cerebrovascular events across a broad spectrum of patients at risk. Guidelines for the management of patients at risk have been established in Europe and North America. The guidelines have advocated progressively lower LDL-C targets and more aggressive use of statin therapy...
April 2016: Journal of the Association of Physicians of India
Hideoki Fukuoka, Fumihiro Sata
Epigenetic modification takes place in many types of environment. Undesirable epigenetic changes for the postnatal life at the developmental stage are induced in utero by exposure to harsh environment such as endocrine disruptors, severe psychological stress and insufficient or excessive nutrition. Some of these changes continues even for a long time after birth from womb to tomb. Under these circumstances with an unhealthy life style, such as higher caloric intake, insufficient exercise, or stress, there is a higher risk of developing various illnesses including lifestyle-related diseases, such as essential hypertension, type 2 diabetes mellitus, dyslipidemia, psychological disorders and cancers...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Mehmet Akif Öztürk, Rıdvan Mercan, Kevser Gök, Ahmet Mesut Onat, Bünyamin Kısacık, Gezmiş Kimyon, Ayşe Balkarlı, Arif Kaya, Veli Çobankara, Mehmet Ali Balcı, ÖmerNuri Pamuk, Gözde Yıldırım Çetin, Mehmet Sayarlıoğlu, Soner Şenel, Mehmet Engin Tezcan, Adem Küçük, Kemal Üreten, Şafak Şahin, Abdurrahman Tufan
Although gout is potentially curable, the management of this disease is often suboptimal. In this study, we investigated the treatment of gout in Turkey and also compared the management approaches to gout in different clinical specialties. Three hundred and nineteen consecutive patients (mean age 58.60 ± 12.8 years; 44 females, 275 males) were included in this multicenter study. A standardized form was generated to collect data about the patient's first admission to health care, the specialty of the doctor first diagnosed the gout, the treatment options for gout including attack management, patient referral, chronic treatment including medical treatment, and life style modifications...
October 8, 2016: Clinical Rheumatology
Silvia Tejada, William Setzer, Maria Daglia, Seyed Fazel Nabavi, Antoni Sureda, Nady Braidy, Olga Gortzi, Seyed Mohammad Nabavi
Neurodegenerative diseases are growing inexorably as the population ages, with enormous economic and social costs. The World Health Organization (WHO) has reported that by 2040, neurodegenerative diseases will overtake cancer to become the second leading cause of natural death, after cardiovascular diseases. Recent investigations suggest that the combination of genes and environmental toxins may contribute to the risk of developing neurodegenerative disorders. Thus, intervention strategies aimed at reducing exposure to risk factors such as life style, smoking, diet, vitamin deficiencies, chemical exposure and pollution are warranted...
October 5, 2016: Current Drug Targets
Narsis A Kiani, Ming-Mei Shang, Jesper Tegnér
Drug discovery is complex and expensive. Numerous drug candidates fail rather late in clinical trials or even after released to the market. This is due to not only commercial considerations and less optimal drug efficacies, but adverse reactions originating from toxic effects constitute a major challenge. During the last two decades significant advances has been made enabling early prediction of toxic effects using in silico techniques. Yet, these essentially statistical techniques have not by design taken the disease driving pathophysiological mechanisms into account...
October 3, 2016: Current Pharmaceutical Design
Xing Peng, Peiqi Xing, Xiuhui Li, Ying Qian, Fuhai Song, Zhouxian Bai, Guangchun Han, Hongxing Lei
Alzheimer's disease (AD) remains to be a grand challenge for the international community despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the disease etiology, which involves very complex and divergent pathways. Therefore, intervention strategies shall be tailored for subgroups of AD patients. Both demographic and in-depth information is needed for patient stratification. The demographic information includes primarily APOE genotype, age, gender, education, environmental exposure, life style, and medical history, whereas in-depth information stems from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripotent cells (iPSCs)...
September 28, 2016: Genomics, Proteomics & Bioinformatics
Kelvin L Walls, Mikael Boulic, John W D Boddy
The United Nations "25 × 25 Strategy" of decreasing non-communicable diseases (NCDs), including cardiovascular diseases, diabetes, cancer and chronic respiratory diseases, by 25% by 2025 does not appear to take into account all causes of NCDs. Its focus is on a few diseases, which are often linked with life-style factors with "voluntary" "modifiable behavioral risk factors" causes tending towards an over-simplification of the issues. We propose to add some aspects of our built environment related to hazardous building materials, and detailed form of the construction of infrastructure and buildings, which we think are some of the missing causes of NCDs...
2016: International Journal of Environmental Research and Public Health
Jean-Pierre Michel
Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the prevalence of the late onset dementia by 50%. After two decades of lack of success in dementia drug discovery and development, and knowing that worldwide, currently 36 million patients have been diagnosed with Alzheimer's disease, a number that will double by 2030 and triple by 2050, the World Health Organization and the Alzheimer's Disease International declared that prevention of cognitive decline was a 'public health priority...
September 2016: Korean Journal of Family Medicine
Ada Ghiggia, Lorys Castelli, Giuseppe Riva, Valentina Tesio, Erica Provenzano, Mattia Ravera, Massimiliano Garzaro, Giancarlo Pecorari, Pierfrancesco Franco, Ilenia Potenza, Monica Rampino, Riccardo Torta
Nasopharyngeal carcinoma (NPC) is the head and neck cancer with the greatest impact on patients' quality of life. The aim of this explorative study is to investigate the psychological distress, coping strategies and quality of life of NPC patients in the post-treatment observation period. Twenty-one patients disease-free for at least two years were assessed with a medical and a psycho-oncological evaluation. Clinically relevant depressive symptoms (CRD) were present in 23.8% of patients and 33.3% reported clinically relevant anxiety symptoms (CRA)...
August 10, 2016: Psychology, Health & Medicine
Jacek Rysz, Anna Gluba-Brzózka, Beata Franczyk, Maciej Banach, Piotr Bartnicki
INTRODUCTION: Despite progress in the understanding of pathogenetic mechanisms of organ cyst formation in autosomal dominant polycystic kidney disease, current treatment methods are insufficient. Experimental studies and clinical trials target at inhibition of cysts development and to slowing CKD progression. AREAS COVERED: The purpose of this analysis is to overview available literature regarding treatment of ADPKD. The most important recent events concerning ADPKD treatment are: the results of TEMPO 3/4 study and the registration of tolvaptan in the treatment of patients with CKD stage I-III and rapidly progressive ADPKD by EMA...
October 2016: Expert Opinion on Pharmacotherapy
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