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https://www.readbyqxmd.com/read/28647714/the-burden-of-multiple-sclerosis-and-patients-coping-strategies
#1
Lorena Lorefice, Giuseppe Fenu, Jessica Frau, Giancarlo Coghe, Maria Giovanna Marrosu, Eleonora Cocco
OBJECTIVES: Multiple sclerosis (MS) is a chronic disease that mainly affects young people. Patients with MS experience several emotional responses to changed perceptions of themselves and manage this situation in ways focused on controlling the overall burden of disease. This present study aimed to evaluate differences between patients with MS and healthy controls (HCs) in coping styles, identifying the MS clinical features that influence adaptive responses. METHODS: Patients with MS, according to the McDonald 2010 criteria, and HCs were recruited...
June 24, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28646833/the-use-of-fruit-extracts-for-production-of-apple-chips-with-enhanced-antioxidant-activity
#2
Tomasz Tarko, Aleksandra Duda-Chodak, Dorota Semik-Szczurak
Background: Style and pace of life make consumers more willing to reach for snack products. This group of processed food includes, among others, fruit chips. Due to the increasing incidence of diseases associated with the excessive exposure to free radicals foods enriched with antioxidant compounds, eg. polyphenols, can be introduced into the sale. Objective: The aim of the study was to use the fruit extracts for the production of apple chips with enhanced antioxidant activity...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28646832/diet-for-women-with-irritable-bowel-syndrome-a-preliminary-study
#3
Diana Wasiluk, Lucyna Ostrowska, Ewa Stefańska, Agnieszka Janke, Grażyna Jurkowska
Background: Irritable Bowel Syndrome (IBS) is one of the most frequent digestive system diseases, of various medical signs. It is assumed that proper life style, including appropriate, rational diet is a factor helpful for treating such a disorder. Objective: The purpose of this paper was to assess the selected dietary habits, and to evaluate the nutritional value of daily food rations for patients with a mixed type of Irritable Bowel Syndrome. Material and Methods: The questionnaire survey involved a group of 32 women suffering from a mixed type of Irritable Bowel Syndrome (The Rome III Diagnostic Criteria were used to diagnose the disease)...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28645738/human-germline-hedgehog-pathway-mutations-predispose-to-fatty-liver
#4
Maria J Guillen Sacoto, Ariel F Martinez, Yu Abe, Paul Kruszka, Karin Weiss, Joshua L Everson, Ramon Bataller, David E Kleiner, Jerrold M Ward, Kathleen K Sulik, Robert J Lipinski, Benjamin D Solomon, Maximilian Muenke
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Activation of hedgehog (Hh) signaling has been implicated in the progression of NAFLD and proposed as a therapeutic target; however, the effects of Hh signaling inhibition have not been studied in humans with germline mutations affecting this pathway. METHODS: Patients with holoprosencephaly (HPE), a disorder associated with germline mutations disrupting Sonic hedgehog (SHH) signaling, were clinically evaluated for NAFLD...
June 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28640118/high-normotension-is-associated-with-future-metabolic-syndrome-but-not-cardiovascular-disease-a-10-year-longitudinal-study
#5
Yen-Lin Chen, Chun-Hsien Hsu, Chang-Hsun Hsieh, Chung-Ze Wu, Jiunn-Diann Lin, Jin-Biou Chang, Yao-Jen Liang, Yi-Ting Tsai, Te-Lin Hsia, Dee Pei
Hypertension and prehypertension can increase the risk of developing cardiovascular disease (CVD) and diabetes. However, whether the harmful effects of high blood pressure (BP) are also seen with high normotension remains unknown. This 10-year longitudinal follow-up study aimed to investigate the relationships among normal-range BP, metabolic syndrome (MetS), and CVD.A total of 9133 nonmedicated normotensive participants, 4634 males and 4499 females, aged 60 years or older were enrolled in a standard health examination program at 2 academic hospitals and a health screening center in Taiwan...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28624982/towards-ageing-well-use-it-or-lose-it-exercise-epigenetics-and-cognition
#6
Irene Maeve Rea
More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. But understanding, how to age long and well, with the avoidance of chronic disease and later life complex disease morbidity is challenging...
June 17, 2017: Biogerontology
https://www.readbyqxmd.com/read/28621560/the-risks-associated-with-prenatal-antidepressant-exposure-time-for-a-precision-medicine-approach
#7
Lars Henning Pedersen
Introduction The prevalence of depression in pregnancy is over 10% and a significant proportion of pregnant women use antidepressant medication. The safety of antidepressants in pregnancy is controversial, partly due to methodological challenges. The conflicting results in the literature may, however, also be due to differences in risks between the study populations related to variations in e.g. degree of depression, type of antidepressant, and lifestyle. Areas covered The literature on the safety of antidepressants in pregnancy is vast and thousands of papers have been published mainly in the last decades...
June 16, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28616059/supramolecular-structure-of-dietary-fat-in-early-life-modulates-expression-of-markers-for-mitochondrial-content-and-capacity-in-adipose-tissue-of-adult-mice
#8
Andrea Kodde, Eline M van der Beek, Esther Phielix, Eefje Engels, Lidewij Schipper, Annemarie Oosting
BACKGROUND: Previous studies have shown that early life nutrition can modulate the development of white adipose tissue and thereby affect the risk on obesity and metabolic disease later in life. For instance, postnatal feeding with a concept infant milk formula with large, phospholipid coated lipid droplets (Concept, Nuturis®), resulted in reduced adiposity in adult mice. The present study investigated whether differences in cell energy metabolism, using markers of mitochondrial content and capacity, may contribute to the observed effects...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28609844/an-overview-on-immunoregulatory-and-anti-inflammatory-properties-of-chrysin-and-flavonoids-substances
#9
REVIEW
Majid Zeinali, Seyed Abdolrahim Rezaee, Hossein Hosseinzadeh
Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system...
June 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28602950/on-phagocytes-and-macular-degeneration
#10
REVIEW
Xavier Guillonneau, Chiara M Eandi, Michel Paques, José-Alain Sahel, Przemyslaw Sapieha, Florian Sennlaub
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumulation of mononuclear phagocytes (MP). We here discuss the origin and nature of subretinal MPs, the mechanisms that lead to their accumulation, the inflammatory mediators they produce as well as the consequences of their chronic presence on photoreceptors, retinal pigment epithelium and choroid...
June 7, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28599070/serum-microcystins-level-positively-linked-with-risk-of-hepatocellular-carcinoma-a-case-control-study-in-southwest-china
#11
Chuanfen Zheng, Hui Zeng, Hui Lin, Jia Wang, Xiaobin Feng, Zhiqun Qiu, Ji-An Chen, Jiaohua Luo, Yang Luo, Yujing Huang, Lingqiao Wang, Wenyi Liu, Yao Tan, Anwei Xu, Yuan Yao, Weiqun Shu
Microcystins have been reported carcinogenic by animal and cell experimentation, but there were no data on the linkage between serum microcystins and hepatocellular carcinoma (HCC) risk in human. We conducted a clinical case-control study to investigate the association between serum microcystins and HCC risk after controlling several known risk factors, such as hepatitis B virus (HBV), alcohol, and aflatoxin. From December 2013 to May 2016, 214 patients newly diagnosed with HCC, along with 214 controls (frequency-matched by age and sex) were recruited from three hospitals in Chongqing, Southwest China...
June 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28593739/systematic-review-and-meta-analysis-to-determine-the-impact-of-iron-depletion-in-dysmetabolic-iron-overload-syndrome-and-nonalcoholic-fatty-liver-disease
#12
Arvind R Murali, Ashutosh Gupta, Kyle Brown
AIMS: Iron reduction has been proposed as treatment for dysmetabolic iron overload syndrome (DIOS) and nonalcoholic fatty liver disease (NAFLD), but results of published trials are conflicting. We aimed to perform a systematic review and meta-analysis to determine the impact of phlebotomy in DIOS and NAFLD. METHODS: We searched multiple databases systematically for studies evaluating impact of phlebotomy in DIOS and NAFLD. We calculated weighted summary estimates using inverse variance method...
June 7, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28577532/parasitic-outbreak-of-the-copepod-balaenophilus-manatorum-in-neonate-loggerhead-sea-turtles-caretta-caretta-from-a-head-starting-program
#13
J L Crespo-Picazo, D García-Parraga, F Domènech, J Tomás, F J Aznar, J Ortega, J M Corpa
BACKGROUND: Diseases associated to external parasitosis are scarcely reported in sea turtles. During the last decades several organism have been documented as a part of normal epibiont community connected to sea turtles. The copepod Balaenophilus manatorum has been cited as a part of epibiont fauna with some concern about its parasitic capacity. This study serves three purposes, i.e. (i) it sheds light on the type of life style that B. manatorum has developed with its hosts, particularly turtles; (ii) it makes a cautionary note of the potential health risks associated with B...
June 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28572983/childhood-overweight-obesity-and-associated-factors-among-primary-school-children-in-dire-dawa-eastern-ethiopia-a-cross-sectional-study
#14
Assefa Desalew, Alemnesh Mandesh, Agumasie Semahegn
BACKGROUND: Obesity in children is increasing worldwide. Malnutrition has become a double burden challenge of public health concern in developing countries. Childhood obesity increases the risk of chronic disease in childhood as well as adulthood. However, information is very scarce about childhood obesity in developing countries specifically in Ethiopia. Therefore, we aimed to assess childhood overweight, obesity and associated factors among primary school children at Dire Dawa, Eastern Ethiopia...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28570956/worry-and-risk-perception-of-breast-cancer-in-a-prevention-trial-of-low-dose-tamoxifen-in-midlife-postmenopausal-hormone-users
#15
Gabriella Rondanina, Matteo Puntoni, Aliana Guerrieri-Gonzaga, Domenico Marra, Bernardo Bonanni, Andrea DeCensi
OBJECTIVE: There is increasing interest in combining postmenopausal hormone therapy (HT) and SERMs in midlife women. We previously showed that refusal to participate in a prevention trial of low dose tamoxifen in HT users was associated with higher worry about breast cancer. Given this counterintuitive finding, we studied which factors influenced worry and risk perception of breast cancer. METHODS: We assessed the relationships of breast cancer worry and risk perception with age, age at menopause, Gail risk, education, adherence to mammographic screening, BMI, smoking, physical activity, alcohol use, anxiety and depression in 457 midlife HT users who were eligible to participate in the trial...
May 29, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28566229/-cardiovascular-risk-and-cardiovascular-events-in-the-general-population-of-the-sanitary-area-of-toledo-ricarto-study
#16
G C Rodríguez-Roca, L Rodríguez-Padial, F J Alonso-Moreno, A Segura-Fragoso, A Villarín-Castro, M L Rodríguez-García, A Menchén-Herreros, G A Rojas-Martelo, J A Fernández-Conde, L M Artigao-Rodenas, J A Carbayo-Herencia, C Escobar-Cervantes, J Hernández-Moreno, J Fernández-Martín
INTRODUCTION: The main aim of this study is to ascertain the prevalence of cardiovascular risk factors (CVRF), target organ damage (TOD), cardiovascular disease (CVD), as well as life habits (physical exercise, alcohol consumption, and Mediterranean diet) in the population of a Health Area in Toledo, Spain, to assess cardiovascular risk (CVR). MATERIAL AND METHODS: Epidemiological and observational study that will analyse a sample from the general population aged 18 years or older, randomly selected from a database of health cards, and stratified by age and gender...
May 26, 2017: Semergen
https://www.readbyqxmd.com/read/28557726/modifiable-resilience-factors-to-childhood-adversity-for-clinical-pediatric-practice
#17
REVIEW
Flora Traub, Renée Boynton-Jarrett
Childhood adversity is highly prevalent and associated with risk for poor health outcomes in childhood and throughout the life course. Empirical literature on resilience over the past 40 years has identified protective factors for traumatized children that improve health outcomes. Despite these empirical investigations of resilience, there is limited integration of these findings into proactive strategies to mitigate the impact of adverse childhood experiences. We review the state of resilience research, with a focus on recent work, as it pertains to protecting children from the health impacts of early adversity...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28553228/how-general-practitioners-and-their-patients-adhere-to-osteoporosis-management-a-follow-up-survey-among-czech-general-practitioners
#18
Magda Vytrisalova, Tereza Touskova, Leos Fuksa, Roman Karascak, Vladimir Palicka, Svatopluk Byma, Jan Stepan
Introduction: General practitioners (GPs) are key participants in osteoporosis (OP) management. The aim was to evaluate their adherence to lege artis management of the disease, potential barriers, and to discuss differences observed in comparison with the baseline survey carried out in 2007; the focus was on secondary prevention. Methods: On behalf of two professional associations, 2-round postal survey among randomly selected GPs (>1/4 of all Czech GPs) was performed in 2014. The questionnaire covered areas concerning GP's role in the fight against OP, knowledge about OP, management of OP-related fractures, barriers to the management of OP, system- and patient-related in particular, and availability and use of information sources...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28551920/-women-s-cardiac-health-from-theory-to-activism
#19
REVIEW
Avital Porter
Cardiovascular disease (CVD) is the leading cause of death in the western world, in both genders. Although awareness of the importance of prevention, diagnosis and optimal treatment of CVD has risen in general, most women are not fully aware of their CVD risk. Moreover, women are not alert to the burden of risk in their reproductive years (e.g. complicated pregnancy and/or peri-menopausal period) and their impact on future CVD. Unique Female issues such as: fertile age, menopause, oral contraceptives, hormonal and metabolic disorders during pregnancy, labor, as well as psychological matters, and healthy life-style are major contributors to primary and secondary prevention of CVD...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28548186/-cardiovascular-risk-factors-among-first-and-third-year-university-students
#20
Gladys Morales, Francisco Guillen-Grima, Sergio Muñoz, Carlos Belmar, Ingrid Schifferli, Andrea Muñoz, Alvaro Soto
BACKGROUND: College students are in a critical stage in their life style due to the transition between high school and university and they may be prone to develop cardiovascular diseases. AIM: To compare the prevalence of cardiovascular risk factors (CVRF) in students from first and third year at the University of La Frontera, Temuco-Chile, according to faculty, gender and socioeconomic status (SES). MATERIAL AND METHODS: Cross-sectional study...
March 2017: Revista Médica de Chile
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