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https://www.readbyqxmd.com/read/27928681/in-vivo-evaluation-of-the-efficacy-of-combined-albedazole-ifn-%C3%AE-treatment-for-cystic-echinococcosis-in-mice
#1
Shengbin Zhang, Yongsheng Zhou, Lifu Su, Xiaodong Zhang, Hao Wang, Baoqin Liu
Cystic echinococcosis (CE) is a serious helminthic zoonosis caused by Echinococcus granulosus metacestode worldwide. The current chemotherapy of CE is mainly based on albendazole (ABZ). However, more than 20% CE cases failed to such chemotherapy. Thus, novel and more efficient treatment options are urgently needed. This study was to evaluate the in vivo efficacy of combined ABZ-interferon (IFN)-α treatment for CE in mice. After 5 months of secondary infection with protoscoleces, mice were randomly allocated into four groups: ABZ-treated group, IFN-α-treated group, ABZ+IFN-α group, and untreated control group...
December 7, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27905625/-epidemiological-description-of-human-and-animal-hydatidosis-in-los-r%C3%A3-os-region-1999-2009
#2
Gerardo Acosta-Jamett, Reinaldo Vargas, Santiago Ernst
OBJECTIVE: To determine the prevalence of hydatidosis in humans and livestock in the Los Ríos region during the years 1999-2009. METHODS: A retrospective survey of all discharge records of patients undergoing removal of cysts produced by Echinococcus granulosus during the period 1999-2009 in the Hospital Clinico Regional of Valdivia was conducted. With the information provided incidence rate, mortality rate and fatality rate were calculated. Additionally, with the aim of determining prevalence of hydatidosis in livestock (i...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27905289/cerebral-alveolar-echinococcosis-concomitant-with-liver-and-lung-lesions-in-a-young-adult-patient-case-report-and-literature-review
#3
Osman Ersegun Batçık, Ahmet Öğrenci, Orkun Koban, Murat Şakir Ekşi, Turgay Bilge
We present the case of a 25-year-old male harboring multiple brain lesions mimicking tumor metastasis that were revealed to be caused by Echinococcus multilocularis. Cerebral echinococcosis with multiple lesions is rare and might be confused with a brain abscess, tuberculoma, or metastatic tumor disease. Brain magnetic resonance imaging and serological studies are helpful in the differential diagnosis. In case of E. multilocularis, cerebral invasion is the late stage of the disease that necessitates an aggressive treatment protocol...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27904546/cured-transudative-pleural-effusion-a-case-report
#4
Mohsen Shafipoor, Arda Kiani, Kambiz Sheikhy, Atefeh Abedini, Majid Golestani Eraghi
Echinococcosis or hydatid disease is a helminthic infection caused by larvae of tapeworm Echinococcus granulosus. While the cysts can involve all organs, liver is the most common site of infection and the lungs are the second most commonly involved organ in young adults. In addition to endemic areas its incidence is growing all around the world due to the ease of transcontinental travel. Disease presentation varies and usually is due to mass effect or dysfunction of the involved organ and surgical resection is the recommended treatment...
2016: Tanaffos
https://www.readbyqxmd.com/read/27899156/echinococcus-multilocularis-in-foxes-and-raccoon-dogs-an-increasing-concern-for-baltic-countries
#5
Guna Bagrade, Gunita Deksne, Zanda Ozoliņa, Samantha Jane Howlett, Maria Interisano, Adriano Casulli, Edoardo Pozio
BACKGROUND: In Europe, the life-cycle of Echinococcus multilocularis is predominantly sylvatic, involving red foxes (Vulpes vulpes) as the main definitive hosts and rodents such as muskrats and arvicolids as intermediate hosts. The parasite is the etiological agent of human alveolar echinococcosis, a malignant zoonotic disease caused by the accidental ingestion of eggs shed by definitive hosts in their faeces. The aims of this study were to investigate the prevalence of E. multilocularis in red foxes and raccoon dogs (Nyctereutes procyonoides) and to study the environmental factors favouring the perpetuation of the parasite in Latvia...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27899131/support-for-targeted-sampling-of-red-fox-vulpes-vulpes-feces-in-sweden-a-method-to-improve-the-probability-of-finding-echinococcus-multilocularis
#6
Andrea L Miller, Gert E Olsson, Sofia Sollenberg, Moa Skarin, Helene Wahlström, Johan Höglund
BACKGROUND: Localized concentrations of Echinococcus multilocularis eggs from feces of infected red fox (Vulpes vulpes) can create areas of higher transmission risk for rodent hosts and possibly also for humans; therefore, identification of these areas is important. However, in a low prevalence environment, such as Sweden, these areas could be easily overlooked. As part of a project investigating the role of different rodents in the epidemiology of E. multilocularis in Sweden, fox feces were collected seasonally from rodent trapping sites in two regions with known parasite status and in two regions with unknown parasite status, 2013-2015...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27888659/intraoperative-diagnosis-of-hydatid-cyst-of-the-ovary-masquerading-as-tumor
#7
Pavneet Kaur Selhi, Sumit Grover, Vikram Narang, Aminder Singh, Neena Sood, Sunil Juneja
Hydatid disease, caused by the larval stage of Echinococcus granulosus, is found most commonly in the liver and lungs, but no organ is immune. The ovarian involvement is often secondary to a cyst's dissemination localized in a different site. Occasionally, the cyst enlarges, thus mimicking an ovarian tumor. Patients with hydatid cysts at unusual locations present with atypical presentations and pose a diagnostic dilemma. A high index of suspicion is required in order to make a correct diagnosis pre-operatively to prevent spillage of the cyst contents during surgery...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27887695/reprint-of-echinococcus-granulosus-sensu-stricto-s-s-from-the-critically-endangered-antelope-addax-nasomaculatus-in-tunisia
#8
Belgees Boufana, Yousra Saïd, Mokhtar Dhibi, Philip S Craig, Samia Lahmar
Echinococcus granulosus sensu lato (s.l.) is a zoonotic disease highly endemic in Tunisia. Canids including stray and semi-stray dogs, jackals and foxes are known as definitive hosts and a wide range of ungulates have been shown to harbour the metacestode hydatid stage and may serve as intermediate hosts. Fertile hydatid cysts of Echinococcus equinus and E. granulosus sensu stricto (s.s.) were recently molecularly identified for the first time from Tunisian donkeys. E. granulosus (s.s.) was also identified from wild boars in Tunisia...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27887693/reprint-of-survey-and-first-molecular-characterization-of-echinococcus-granulosus-sensu-stricto-g1-in-pampas-fox-lycalopex-gymnocercus-in-buenos-aires-province-argentina
#9
Nathalia Paula Scioscia, Romina Sandra Petrigh, Pablo Martín Beldomenico, Martín Fugassa, Guillermo María Denegri
Echinococcosis is a zoonosis caused by tapeworms of the genus Echinococcus. Echinococcus granulosus sensu lato (s. l.) has a world-wide distribution and its transmission is primarily maintained in a synanthropic cycle with dogs as definitive hosts and livestock species as intermediate hosts. However, many wild canids also function as definitive hosts for E. granulosus s. l. Echinococcosis in humans is mainly caused by E. granulosus sensu stricto (s. s.) G1 genotype. In the present work, we expanded the epidemiological study on echinococcosis reported cases in Pampas fox (Lycalopex gymnocercus) to provide a prevalence estimate for rural areas of southern Buenos Aires province, Argentina...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27884437/evaluation-by-latent-class-analysis-of-a-magnetic-capture-based-dna-extraction-followed-by-real-time-qpcr-as-a-new-diagnostic-method-for-detection-of-echinococcus-multilocularis-in-definitive-hosts
#10
Miriam Maas, Annika van Roon, Cecile Dam-Deisz, Marieke Opsteegh, Alessandro Massolo, Gunita Deksne, Peter Teunis, Joke van der Giessen
A new method, based on a magnetic capture based DNA extraction followed by qPCR, was developed for the detection of the zoonotic parasite Echinococcus multilocularis in definitive hosts. Latent class analysis was used to compare this new method with the currently used phenol-chloroform DNA extraction followed by single tube nested PCR. In total, 60 red foxes and coyotes from three different locations were tested with both molecular methods and the sedimentation and counting technique (SCT) or intestinal scraping technique (IST)...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27882065/hepatic-alveolar-hydatid-cyst-a-brief-review-of-published-cases-from-iran-in-the-last-20-years
#11
REVIEW
Bita Geramizadeh, Mohammad Baghernezhad
CONTEXT: Echinococcus multilocularis is the cause of alveolar hydatid disease, which most commonly involves the liver in more than 90% of cases. This disease is endemic in northern Iran. However, there are very few published cases from Iran. In this article, we will review all of the published cases of hepatic alveolar echinococcosis from Iran regarding all aspects, including clinical, paraclinical, and treatment protocols. EVIDENCE ACQUISITION: In this brief review, the published cases of hepatic Alveolar Echinococcosis (AE) from Iran were retrieved for review via a search in PubMed, Scopus, Google Scholar, IranMedex, scientific information database (SID), Magiran, and Irandoc (1995 - 2015) using the keywords Echinococcus multilocularis and Iran, Alveolar hydatid cyst and Iran, liver and Alveolar hydatid cyst and Iran, and Hepatic alveolar hydatid cyst and Iran...
October 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27876984/first-serological-study-of-equine-hydatidosis-in-iran
#12
Ehsanollah Sakhaee, Mehdi Golchin, Hamidreza Amiri, Mohammad Reza Fayed, Jamaladdin Eydi
Hydatidosis, is an important worldwide zoonotic disease caused by larval stages (metacestodes) of tapeworm parasites of the genus Echinococcus. The objective of the present study was to determine the seroprevalence of equine hydatidosis in Iran by latex agglutination test. This study also served to correlate sex and age with mentioned results in cases. Therefore, 193 serum samples were collected from clinically healthy horses at 9 race clubs in Kerman, Yazd and Golestan provinces, Iran. According to the results, antibodies against hydatidosis were detected in 6 sera (3...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876940/echinococcus-granulosus-in-humans-associated-with-disease-incidence-in-domestic-animals-in-kermanshah-west-of-iran
#13
Abdolali Chalechale, Mohammad Hashemnia, Farid Rezaei, Maryam Sayadpour
Hydatidosis is one of the important zoonotic diseases that cause considerable economic losses and public health problems worldwide. This study was conducted to determine the prevalence Echinococcus granulosus in people and slaughtered animals in Kermanshah province, west of Iran. Hospitals data and meat-inspection records in Kermanshah abattoir were used in this study. A total number of 32,130 slaughtered livestock (7000 cattle, 19,950 sheep and 5180 goats) was inspected in the 3-year period and overall 2043 (6...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876932/zataria-multiflora-bioss-lethal-effects-of-methanolic-extract-against-protoscoleces-of-echinococcus-granulosus
#14
Sareh Jahanbakhsh, Mojgan Azadpour, Amir Tavakoli Kareshk, Amir Keyhani, Hossein Mahmoudvand
The present study was aimed to evaluate the lethal effects of Zataria multiflora Boiss (Lamiaceae) methanolic extract against Echinococcus granulosus protoscoleces. Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (2.5-20 mg/mL) were used for 10-60 min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1 % eosin staining). Obtained results showed that Z. multiflora extract at the concentration of 20 mg/mL after 10 min of exposure killed 100 % protoscoleces...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876908/effect-of-two-hydatid-cyst-antigens-on-the-growth-of-melanoma-cancer-in-c57-black-mice
#15
Milad Badri Chookami, Seyedeh Maryam Sharafi, Raheleh Rafiei Sefiddashti, Rasool Jafari, Mehran Bahadoran, Nader Pestechian, Hossein Yousofi Darani
Hydatid cyst is the larval stage of Echinococcus granulosus. In previous studies inhibitory effect of this parasite on cancer cell growth in culture medium has been shown. In this study effect of hydatid cyst antigens on tumor growth in experimental animals has been investigated. Two antigens of hydatid cyst including protoscolices excretory secretory antigen and hydatid fluid absorbed on alum as adjuvant were injected to two groups of C57/black mice as case groups. Control groups were injected with only saline and alum...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27853123/differential-expression-of-hox-and-notch-genes-in-larval-and-adult-stages-of-echinococcus-granulosus
#16
Ebrahim Saedi Dezaki, Mohammad Mehdi Yaghoobi, Elham Taheri, Pooya Ghaseminejad Almani, Farideh Tohidi, Bruno Gottstein, Majid Fasihi Harandi
This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E...
October 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27846915/alveolar-echinococcosis-of-the-right-adrenal-gland-a-case-report-and-review-of-the-literature
#17
Silke Spahn, Birgit Helmchen, Urs Zingg
BACKGROUND: Extrahepatic manifestations of Echinococcus multilocularis are very rare, especially in the adrenal glands. To the best of our knowledge, only seven cases of adrenal alveolar echinococcosis have been reported, all from the Far East. All of these occurred exclusively in the right adrenal gland. CASE PRESENTATION: We report a rare case of an extrahepatic alveolar echinococcosis in an asymptomatic 78-year-old white man with an incidentaloma of his right adrenal gland...
November 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27830083/the-seroprevalence-of-human-cystic-echinococcosis-in-iran-a-systematic-review-and-meta-analysis-study
#18
REVIEW
Reza Shafiei, Saeed Hosseini Teshnizi, Kurosh Kalantar, Maryam Gholami, Golnush Mirzaee, Fatemeh Mirzaee
Human cystic echinococcosis (HCE), a zoonotic infection of the larval stage of Echinococcus granulosus, has high effect on public health in human population all around the world. Iran is one of the most important endemic areas in the Middle East. This systematic review and meta-analysis was performed to evaluate the seroprevalence of HCE in Iranian population. An electronic search for articles from 1985 until April 2015 was performed using data bases PubMed, Scopus, Google Scholar, Magiran, IranMedex, Iran Doc, and Scientific Information Database (SID) both in English and in Persian...
2016: Journal of Parasitology Research
https://www.readbyqxmd.com/read/27810427/mirna-profiling-in-the-mice-in-response-to-echinococcus-multilocularis-infection
#19
Xiaoliang Jin, Xiaola Guo, Dongqing Zhu, Mazhar Ayaz, Yadong Zheng
miRNAs are small non-coding regulatory RNAs and actively contribute to the pathogenesis of parasitic diseases in multiple ways. The influence of Echinococcus multilocularis infection on host miRNAs remains unclear. Herein, it was shown that E. multilocularis infection disturbed the expression of 4 of 10 genes essential to miRNA biogenesis in the mouse liver, including ago1, ago4, tarbp2 and xrn2. Comparative analysis of deep sequencing data identified 46 differentially expressed miRNAs with 93.5% (43/46) being down-regulated, some of which are associated with modulation of liver cell death and fibrosis, and GO analysis revealed that these miRNAs were mainly enriched in signal transduction (p<0...
October 31, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27810319/gene-flow-for-echinococcus-granulosus-metapopulations-determined-by-mitochondrial-sequences-a-reliable-approach-for-reflecting-epidemiological-drift-of-parasite-among-neighboring-countries
#20
Mahmoud Mahami-Oskouei, Azam Kaseb-Yazdanparast, Adel Spotin, Abbas Shahbazi, Mohammad Adibpour, Ehsan Ahmadpour, Nader Ghabouli-Mehrabani
In genetic diversity and population structure of Echinococcus granulosus, the gene flow can illustrate how the Echinococcus isolates have epidemiologically drifted among endemic neighboring countries. 51 isolates of hydatid cysts were collected from human, dog, cattle and sheep in northwest Iran, where placed co-border with Turkey. DNA samples were extracted, amplified and subjected to sequence analysis of NADH dehydrogenase subunit 1 (nad1) and cytochrome oxidase subunit 1 (cox1) genes. As well, sequences of Echinococcus at east to the southeast regions of Turkey were retrieved from GenBank database for the cox1 gene...
October 31, 2016: Experimental Parasitology
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