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https://www.readbyqxmd.com/read/28816101/measurement-of-total-hemoglobin-reduces-red-cell-transfusion-in-hospitalized-patients-undergoing-cardiac-surgery-a-retrospective-database-analysis
#1
Christopher Craver, Kathy W Belk, Gerard J Myers
INTRODUCTION: Historically, perioperative hemoglobin monitoring has relied on calculated saturation, using blood gas devices that measure plasma hematocrit (Hct). Co-oximetry, which measures total hemoglobin (tHb), yields a more comprehensive assessment of hemodilution. The purpose of this study was to examine the association of tHb measurement by co-oximetry and Hct, using conductivity with red blood cell (RBC) transfusion, length of stay (LOS) and inpatient costs in patients having major cardiac surgery...
August 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28811589/patients-with-igg1-anti-red-blood-cell-autoantibodies-show-aberrant-fc-glycosylation
#2
Myrthe E Sonneveld, Masja de Haas, Carolien Koeleman, Noortje de Haan, Sacha S Zeerleder, Peter C Ligthart, Manfred Wuhrer, C Ellen van der Schoot, Gestur Vidarsson
Autoimmune hemolytic anemia (AIHA) is a potentially severe disease in which red blood cells (RBC) are destroyed by IgG anti-RBC autoantibodies which can lead to hemolysis. We recently found IgG Fc-glycosylation towards platelet and RBC alloantigens to be skewed towards decreased fucosylation, increased galactosylation and sialylation. The lowered core-fucosylation increases the affinity of the pathogenic alloantibodies to FcγRIIIa/b, and hence RBC destruction. It is known that in autoimmune diseases plasma IgG1 galactosylation and sialylation are lowered, but Fc-glycosylation of RBC-specific autoantibodies has never been thoroughly analyzed...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811304/selectin-catch-bonds-mechanotransduce-integrin-activation-and-neutrophil-arrest-on-inflamed-endothelium-under-shear-flow
#3
Vasilios A Morikis, Shannon Chase, Ted Wun, Elliot L Chaikof, John L Magnani, Scott I Simon
E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands are glycosylated with the tetrasaccharide sialyl Lewis(x) (sLe(x)), which contributes to bond affinity and specificity. E-selectin mediated rolling transmits signals into neutrophils that triggers activation of high-affinity β2-integrins necessary for transition to shear resistant adhesion and transendothelial migration...
August 15, 2017: Blood
https://www.readbyqxmd.com/read/28804957/pre-and-post-transfusion-alloimmunization-in-dogs-characterized-by-2-antiglobulin-enhanced-cross-match-tests
#4
I Goy-Thollot, U Giger, C Boisvineau, R Perrin, M Guidetti, B Chaprier, A Barthélemy, C Pouzot-Nevoret, B Canard
BACKGROUND: When dogs are transfused, blood compatibility testing varies widely but may include dog erythrocyte antigen (DEA) 1 typing and rarely cross-matching. OBJECTIVES: Prospective study to examine naturally occurring alloantibodies against red blood cells (RBCs) and alloimmunization by transfusion using 2 antiglobulin-enhanced cross-match tests. ANIMALS: Eighty client-owned anemic, 72 donor, and 7 control dogs. METHODS: All dogs were typed for DEA 1 and some also for DEA 4 and DEA 7...
August 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28804463/effect-of-oral-docosahexaenoic-acid-dha-supplementation-on-dha-levels-and-omega-3-index-in-red-blood-cell-membranes-of-breast-cancer-patients
#5
Alessio Molfino, Maria I Amabile, Sara Mazzucco, Gianni Biolo, Alessio Farcomeni, Cesarina Ramaccini, Simonetta Antonaroli, Massimo Monti, Maurizio Muscaritoli
Rationale: Docosahexaenoic acid (DHA) in cell membrane may influence breast cancer (BC) patients' prognosis, affecting tumor cells sensitivity to chemo- and radio-therapy and likely modulating inflammation. The possibility of identifying BC patients presenting with low DHA levels and/or low ability of DHA incorporation into cell membrane might help to treat this condition. Methods: We enrolled BC patients and healthy controls, recording their seafood dietary intake. DHA in form of algal oil was administered for 10 consecutive days (2 g/day)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28803752/optimal-dose-timing-and-ratio-of-blood-products-in-massive-transfusion-results-from-a-systematic-review
#6
REVIEW
Zoe K McQuilten, Gemma Crighton, Susan Brunskill, Jessica K Morison, Tania H Richter, Neil Waters, Michael F Murphy, Erica M Wood
Optimal dose, timing and ratio to red blood cells (RBC) of blood component therapy (fresh frozen plasma [FFP], platelets, cryoprecipitate or fibrinogen concentrate) to reduce morbidity and mortality in critically bleeding patients requiring massive transfusion is unknown. We performed a systematic review for randomized controlled trials (RCT) in MEDLINE, The Cochrane Library, Embase, CINAHL, PubMed the Transfusion Evidence Library and using multiple clinical trials registries to 21 February 2017. Sixteen RCTs were identified: six completed (five in adult trauma patients, one pediatric burn patients) and ten ongoing trials...
July 6, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28801994/influence-of-feeding-hematocrit-and-perfusion-pressure-on-hematocrit-reduction-f%C3%A3-hraeus-effect-in-an-artificial-microvascular-network
#7
Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas
OBJECTIVE: Hematocrit in narrow vessels is reduced due to concentration of fast flowing red blood cells (RBC) in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local hematocrit in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding hematocrit and perfusion pressure on the Fåhraeus effect in an artificial microvascular network (AMVN)...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28801570/the-buckling-instability-of-aggregating-red-blood-cells
#8
Daniel Flormann, Othmane Aouane, Lars Kaestner, Christian Ruloff, Chaouqi Misbah, Thomas Podgorski, Christian Wagner
Plasma proteins such as fibrinogen induce the aggregation of red blood cells (RBC) into rouleaux, which are responsible for the pronounced shear thinning behavior of blood, control the erythrocyte sedimentation rate (ESR) - a common hematological test - and are involved in many situations of physiological relevance such as structuration of blood in the microcirculation or clot formation in pathological situations. Confocal microscopy is used to characterize the shape of RBCs within rouleaux at equilibrium as a function of macromolecular concentration, revealing the diversity of contact zone morphology...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798852/flow-reproducibility-of-whole-blood-and-other-bodily-fluids-in-simplified-no-reaction-lateral-flow-assay-devices
#9
H Li, D Han, M A Hegener, G M Pauletti, A J Steckl
The "no reaction" lateral flow assay (nrLFA) uses a simplified LFA structure with no conjugate pad and no stored reagents. In the nrLFA, the capillary-based transport time or distance is the key indicator, rather than the outcome of a biochemical reaction. Hence, the calibration and reproducibility of the nrLFA device are critical. The capillary flow properties of several membrane types (nitrocellulose, nylon, cellulose acetate, polyethersulfone, and polyvinylidene difluoride) are evaluated. Flow rate evaluations of MilliporeSigma Hi-Flow™ Plus (HF075, HF135 and HF180) nitrocellulose membranes on nrLFA are performed using bodily fluids (whole blood, blood plasma, and artificial sweat)...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28798850/network-simulation-based-optimization-of-centrifugo-pneumatic-blood-plasma-separation
#10
S Zehnle, M Rombach, R Zengerle, F von Stetten, N Paust
Automated and robust separation of 14 μl of plasma from 40 μl of whole blood at a purity of 99.81% ± 0.11% within 43 s is demonstrated for the hematocrit range of 20%-60% in a centrifugal microfluidic polymer disk. At high rotational frequency, red blood cells (RBCs) within whole blood are concentrated in a radial outer RBC collection chamber. Simultaneously, plasma is concentrated in a radial inner pneumatic chamber, where a defined air volume is enclosed and compressed. Subsequent reduction of the rotational frequency to not lower than 25 Hz enables rapid transfer of supernatant plasma into a plasma collection chamber, with highly suppressed resuspension of red blood cells...
March 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28783866/hematologic-and-plasma-chemistry-ris-for-cultured-striped-catfish-pangasius-hypophthalmus-in-recirculating-aquaculture-systems
#11
Oscar A Galagarza, David D Kuhn, Stephen A Smith, Terry C Hrubec
BACKGROUND: Striped catfish (Pangasius hypophthalmus) is a valuable aquaculture fish species produced primarily in Southeast Asia. In the United States, it is bred as an ornamental species. Striped catfish has high productivity and great demand in numerous countries around the world, yet little is known about its normal physiology. OBJECTIVES: The objective of this study was to establish hematologic and blood chemistry RIs for healthy juvenile Striped catfish. METHODS: Blood samples were collected from 70 Striped catfish raised in recirculating aquaculture systems...
August 7, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28780990/folate-and-vitamin-b12-status-is-associated-with-insulin-resistance-and-metabolic-syndrome-in-morbid-obesity
#12
Zhen Li, Rosa-Maria Gueant-Rodriguez, Didier Quilliot, Marie-Aude Sirveaux, David Meyre, Jean-Louis Gueant, Laurent Brunaud
BACKGROUND: Low vitamin B12 and high folate during pregnancy are associated with visceral obesity and insulin resistance in offspring. In the general population, high folate exacerbates the increase of methylmalonic acid, a marker of vitamin B12 deficiency. However, the influence of vitamin B12 and folate and their related markers on insulin resistance and metabolic syndrome remains unknown in severe obesity. AIM: To evaluate the influence of vitamin B12 and folate on HOMA-IR and components of metabolic syndrome in severe obesity...
July 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28767202/effects-of-parenteral-fish-oil-on-plasma-nonesterified-fatty-acids-and-systemic-inflammatory-mediators-in-dogs-following-ovariohysterectomy
#13
Kaoru Tsuruta, Robert C Backus, Amy E DeClue, Kevin L Fritsche, Fred A Mann
OBJECTIVE: To evaluate the effects of intravenous (IV) infusion of fish oil (FO) emulsion following ovariohysterectomy (OVH) on inflammatory mediators and plasma omega-3 nonesterified fatty acids (NEFA) concentrations in dogs. DESIGN: Prospective clinical study. SETTING: University teaching hospital. ANIMALS: Twenty-nine privately owned dogs undergoing routine OVH. INTERVENTIONS: Postoperative 3-hour IV infusion of saline (n = 9), FO (Omegaven, n = 10), or soybean oil (SO, intralipid, n = 10) emulsion and blood collected before, 5 and 24 hours following OVH for plasma NEFA and RBC membrane fatty acids (FAs) concentrations, leukocyte cytokine production capacity, and C-reactive protein (CRP) measurement...
August 2, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28754640/the-pathogenesis-of-chronic-subdural-hematomas-a-study-on-the-formation-of-chronic-subdural-hematomas-and-analysis-of-ct-findings
#14
Neda Jafari, Lyle Gesner, Joseph M Koziol, Giorgio Rotoli, Otakar R Hubschmann
The origin of chronic subdural hematomas (CSDH) and the pathophysiology of its enlargement remain unknown. The chemical fluid composition of CSDH the contribution of CSF to its enlargement and the relationship to its appearance on CT appearance is also not entirely clear. In this prospective study, 58 samples in 41 patients treated surgically for CSDH were analyzed. The CSDH were evaluated for the presence of CSF using beta-2 transferrin (β2T) and substances, related to cell breakdown and hemolysis. These were compared to normal value of those substances in the serum and the CT appearances of the CSDH...
July 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28737229/advances-in-transfusion-medicine-gastrointestinal-bleeding
#15
REVIEW
K Oakland, V Jairath, M F Murphy
Gastrointestinal bleeding is a common medical and surgical emergency and is the second most common indication for red blood cell (RBC) transfusion in the UK. Most transfusion guidelines recommend the use of restrictive blood transfusion in stable gastrointestinal bleeding. This review explores the evidence supporting this practice, including whether it is safe in lower as well as upper gastrointestinal bleeding, and the risks of restrictive transfusion in patients with cardiovascular disease. There is a lack of evidence supporting the use of platelet and fresh frozen plasma transfusion in gastrointestinal bleeding...
July 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28734877/enzymatic-and-free-radical-formation-of-cis-and-trans-epoxyeicosatrienoic-acids-in-vitro-and-in-vivo
#16
Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid (AA) oxidation that have important cardioprotective and signaling properties. AA is an ω-6 polyunsaturated fatty acid (PUFA) that is prone to autoxidation. Although hydroperoxides and isoprostanes are major autoxidation products of AA, EETs are also formed from the largely overlooked peroxyl radical addition mechanism. While autoxidation yields both cis- and trans-EETs, cytochrome P450 (CYP) epoxygenases have been shown to exclusively catalyze the formation of all regioisomer cis-EETs, on each of the double bonds...
July 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28722518/effects-of-pentoxifylline-on-hemodynamic-hemorheological-and-microcirculatory-parameters-in-young-shrs-during-arterial-hypertension-development
#17
Mark B Plotnikov, Oleg I Aliev, Alexander Y Shamanaev, Anastasia V Sidekhmenova, Yana Anfinogenova, Anna M Anishchenko, Tatiana I Fomina, Alexander M Arkhipov
The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28719428/blood-product-utilization-among-trauma-and-nontrauma-massive-transfusion-protocols-at-an-urban-academic-medical-center
#18
Eshan U Patel, Paul M Ness, Christi E Marshall, Thomas Gniadek, David T Efron, Peter M Miller, Joseph A Zeitouni, Karen E King, Evan M Bloch, Aaron A R Tobian
BACKGROUND: Hospital-wide massive transfusion protocols (MTPs) primarily designed for trauma patients may lead to excess blood products being prepared for nontrauma patients. This study characterized blood product utilization among distinct trauma and nontrauma MTPs at a large, urban academic medical center. METHODS: A retrospective study of blood product utilization was conducted in patients who required an MTP activation between January 2011 and December 2015 at an urban academic medical center...
September 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28718522/t2-prepared-balanced-steady-state-free-precession-bssfp-for-quantifying-whole-blood-oxygen-saturation-at-1-5t
#19
Ana E Rodríguez-Soto, Osheiza Abdulmalik, Michael C Langham, Nadav Schwartz, Hyunyeol Lee, Felix W Wehrli
PURPOSE: To establish a calibration equation to convert human blood T2 to the full range of oxygen saturation levels (HbO2 ) and physiologic hematocrit (Hct) values using a T2 -prepared balanced steady-state free precession sequence (T2 -SSFP) at 1.5T. METHODS: Blood drawn from 10 healthy donors (29.1 ± 3.9 years old) was prepared into samples of varying HbO2 and Hct (n = 79), and imaged using T2 -SSFP sequence at 37°C and interrefocusing interval τ180  = 12 ms...
July 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28705992/beyond-just-hemoglobin-red-blood-cell-potentiation-of-hemoglobin-oxygen-unloading-in-fish
#20
Colin J Brauner, Till S Harter
Teleosts comprise 95% of fish species, and almost half of all vertebrate species, and represent one of the most successful adaptive radiation events among vertebrates. This is thought to be in part due to their unique oxygen (O2) transport system. In salmonids, recent in vitro and in vivo studies indicate that hemoglobin-oxygen (Hb-O2) unloading to tissues may be doubled or even tripled under some conditions without changes in perfusion. This is accomplished through the short-circuiting of red blood cell (RBC) pH regulation resulting in a large arterial-venous pH difference within the RBC and induced reduction in Hb-O2 affinity...
July 13, 2017: Journal of Applied Physiology
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