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Treatment of Shock

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https://www.readbyqxmd.com/read/29227368/septic-cardiomyopathy
#1
Sarah J Beesley, Gerhard Weber, Todd Sarge, Sara Nikravan, Colin K Grissom, Michael J Lanspa, Sajid Shahul, Samuel M Brown
OBJECTIVES: To describe, with an emphasis on clinical applications, what is known about the pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU. DATA SOURCES AND STUDY SELECTION: A PubMed literature review was performed for relevant articles. Only articles in English that studied human adults with sepsis were included. DATA EXTRACTION AND DATA SYNTHESIS: Multiple competing definitions for septic cardiomyopathy hinder understanding of this entity...
December 8, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29227118/complex-suicide-involving-pyrethroid-ingestion-mosquito-coils-and-fatal-self-wounding-by-sharp-force
#2
Maria -Valeria Karakasi, Pavlos Pavlidis, Epameinondas Vasilikos, Doxakis Anestakis, Nikolaos Raikos
"Complex suicide" is a term referring to the suicidal pattern in which more than one suicidal method is applied in the purpose of inducing death. The present paper aims to review complex suicide literature shortly and investigate an unusual planned complex suicide incident, the rarity of which is attributable to the combination of suicide methods as well as the type and quantity of substances applied to induce poisoning. A 33-year-old man with a history of psychotic depression was found dead in his bedroom lying within a large quantity of blood...
2017: Soudní Lékarství
https://www.readbyqxmd.com/read/29225167/adenovirus-infection-induces-hur-relocalization-to-facilitate-virus-replication
#3
Jumond P Jehung, Tetsuya Kitamura, Aya Yanagawa-Matsuda, Takeshi Kuroshima, Alam Towfik, Motoaki Yasuda, Hidehiko Sano, Yoshimasa Kitagawa, Kazuyuki Minowa, Masanobu Shindoh, Fumihiro Higashino
HuR is an RNA-binding protein of the embryonic lethal abnormal vision (ELAV) family, which binds to the AU-rich element (ARE) in the 3'-untranslated region (UTR) of certain mRNAs and is involved in the nucleo-cytoplasmic export and stabilization of ARE-mRNAs. The cytoplasmic relocalization of ARE-mRNAs with several proteins such as HuR and pp32 increases in cells transformed by the adenovirus oncogene product E4orf6. Additionally, these ARE-mRNAs were stabilized and acquired the potential to transform cells...
December 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29225011/effect-of-platelet-lymphocyte-ratio-and-lactate-levels-obtained-on-mortality-with-sepsis-and-septic-shock
#4
Ebru Biyikli, Afsin Emre Kayipmaz, Cemil Kavalci
BACKGROUND: Sepsis is a potentially fatal condition with high treatment costs, and is especially common among the elderly population. The emergency management of septic patients has gained importance. OBJECTIVE: Herein, we investigated the effect of admission lactate levels and the platelet-lymphocyte ratio (PLR) on the 30-day mortality among patients older than 65years who were diagnosed with sepsis and septic shock according to the qSOFA criteria at our hospital's emergency department...
December 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29224660/postpartum-hemorrhage
#5
Janice Newsome, Jonathan G Martin, Zachary Bercu, Jay Shah, Haris Shekhani, Gail Peters
Interventional radiologists are often called for emergent control of abnormal uterine bleeding. Bleeding, even heavy bleeding as a result of uterine fibroids is not a common emergent procedure; instead, pregnancy and pregnancy related conditions, trauma and malignancy associated with bleeding can be the source of many interventional radiology on call events or procedures. Postpartum hemorrhage (PPH) is the most common cause, and is defined as blood loss of 500mL after vaginal delivery or 1000mL after cesarean section...
December 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29224568/internal-herniation-through-lesser-omentum-hiatus-and-gastrocolic-ligament%C3%A2-with-malrotation-a-case-report
#6
Ang Li, Renwang Hu, Dong Zhou, Senmao Li, Dan Huang, Xin Wei, Zhixin Cao
BACKGROUND: Internal herniation through lesser omentum hiatus and gastrocolic ligament with malrotation is extremely rare. This type of internal hernia has rarely been described before. Preoperative diagnosis is difficult and prone to misdiagnosis. CASE PRESENTATION: A 38-year-old Chinese woman was an emergency admission to our hospital with a sudden onset of acute epigastralgia for the past 14 hours. We made a presumptive diagnosis of gastrointestinal perforation and septic shock...
December 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29223709/bone-marrow-edema-syndrome-of-the-medial-femoral-condyle-treated-with-extracorporeal-shock-wave-therapy-a-clinical-and-mri-retrospective-comparative-study
#7
Matteo Vitali, Nadim Naim Rodriguez, Alberto Pedretti, Andreas Drossinos, Pierluigi Pironti, Gaia Di Carlo, Gianfranco Fraschini
OBJECTIVE: To determine the validity of Extracorporeal Shock Wave Therapy (ESWT) in the treatment of Bone Marrow Edema (BME) of the medial condyle of the knee DESIGN: Retrospective STUDY SETTING: IRCCS San Raffaele Hospital, Orthopedics Outpatient Clinic PARTICIPANTS: Fifty-six symptomatic patients affected by bone marrow edema of the medial condyle of the knee. Patients were equally divided in a ESWT (Extracorporeal Shock Wave Therapy) treated group and a control group, which was managed conservatively...
December 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29223432/contemporary-risk-model-for-inhospital-major-bleeding-for-patients-with-acute-myocardial-infarction-the-acute-coronary-treatment-and-intervention-outcomes-network-action-registry%C3%A2-get-with-the-guidelines-gwtg-%C3%A2
#8
Nihar R Desai, Kevin F Kennedy, David J Cohen, Traci Connolly, Deborah B Diercks, Mauro Moscucci, Stephen Ramee, John Spertus, Tracy Y Wang, Robert L McNamara
BACKGROUND: Major bleeding is a frequent complication for patients with acute myocardial infarction (AMI) and is associated with significant morbidity and mortality. OBJECTIVE: To develop a contemporary model for inhospital major bleeding that can both support clinical decision-making and serve as a foundation for assessing hospital quality. METHODS: An inhospital major bleeding model was developed using the Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines (ACTION Registry-GWTG) database...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29222696/thrombomodulin-favors-leukocyte-microvesicle-fibrinolytic-activity-reduces-netosis-and-prevents-septic-shock-induced-coagulopathy-in-rats
#9
Julie Helms, Raphaël Clere-Jehl, Elsa Bianchini, Pierrick Le Borgne, Mélanie Burban, Fatiha Zobairi, Jean-Luc Diehl, Lelia Grunebaum, Florence Toti, Ferhat Meziani, Delphine Borgel
BACKGROUND: Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality. Immunothrombosis-induced coagulopathy may contribute to hypercoagulability. We aimed at determining whether recombinant human thrombomodulin (rhTM) could control exaggerated immunothrombosis by studying procoagulant responses, fibrinolysis activity borne by microvesicles (MVs) and NETosis in septic shock. METHODS: In a septic shock model after a cecal ligation and puncture-induced peritonitis (H0), rats were treated with rhTM or a placebo at H18, resuscitated and monitored during 4 h...
December 8, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/29221333/successful-treatment-of-a-ruptured-left-internal-mammary-artery-aneurysm-with-a-delayed-diagnosis-of-type-i-neurofibromatosis
#10
Do Wan Kim, In Seok Jeong, Kook Joo Na, Bong Suk Oh, Byung Hee Ahn, Sang Yun Song
Neurofibromatosis type I (NF-1) induced vasculopathy is rare but catastrophic complication after aneurysmal rupture. We present the case of a 55-year-old female who developed hypovolemic shock because of left internal mammary artery (IMA) pseudoaneurysm rupture associated with NF-1. Even she was not detected NF-1 at the time of arrival in emergency room. We decided to perform percutaneous embolization instead of surgical approach. In this case, after intervention, the ruptured left IMA aneurysm was well treated...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220765/transient-disturbance-of-engineered-zno-nanoparticles-enhances-the-resistance-and-resilience-of-anammox-process-in-wastewater-treatment
#11
Zheng-Zhe Zhang, Ya-Fei Cheng, Lian-Zeng-Ji Xu, Yu-Hui Bai, Jia-Jia Xu, Zhi-Jian Shi, Qian-Qian Zhang, Ren-Cun Jin
The increasing use of engineered nanoparticles (NPs) in consumer and industrial products raises concerns about their environmental impacts, but their potential influence on anaerobic ammonium oxidation (anammox) process in wastewater treatment remains unknown. In this study, the response of granule-based anammox reactor to different loads of ZnONPs was investigated. The introduction of 1-5mgL-1 ZnONPs did not affect reactor performance, but 90% of the nitrogen removal capacity was deprived by a shock of 10mgL-1 ZnONPs within 3days...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220364/an-attempt-to-interpret-a-biochemical-mechanism-of-c4-photosynthetic-thermo-tolerance-under-sudden-heat-shock-on-detached-leaf-in-elevated-co2-grown-maize
#12
Mingnan Qu, James A Bunce, Richard C Sicher, Xiaocen Zhu, Bo Gao, Genyun Chen
Detached leaves at top canopy structures always experience higher solar irradiance and leaf temperature under natural conditions. The ability of tolerance to high temperature represents thermotolerance potential of whole-plants, but was less of concern. In this study, we used a heat-tolerant (B76) and a heat-susceptible (B106) maize inbred line to assess the possible mitigation of sudden heat shock (SHS) effects on photosynthesis (PN) and C4 assimilation pathway by elevated [CO2]. Two maize lines were grown in field-based open top chambers (OTCs) at ambient and elevated (+180 ppm) [CO2]...
2017: PloS One
https://www.readbyqxmd.com/read/29218493/direct-biological-effects-of-fractional-ultrapulsed-co2-laser-irradiation-on-keratinocytes-and-fibroblasts-in-human-organotypic-full-thickness-3d-skin-models
#13
L Schmitt, S Huth, P M Amann, Y Marquardt, R Heise, K Fietkau, L Huth, T Steiner, F Hölzle, J M Baron
Molecular effects of various ablative and non-ablative laser treatments on human skin cells-especially primary effects on epidermal keratinocytes and dermal fibroblasts-are not yet fully understood. We present the first study addressing molecular effects of fractional non-sequential ultrapulsed CO2 laser treatment using a 3D skin model that allows standardized investigations of time-dependent molecular changes ex vivo. While histological examination was performed to assess morphological changes, we utilized gene expression profiling using microarray and qRT-PCR analyses to identify molecular effects of laser treatment...
December 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29218314/endoscopic-pancreatic-balloon-sphincteroplasty-for-difficult-to-treat-pancreatic-stones-and-strictures-experience-in-80-patients
#14
Rinkesh Kumar Bansal, Gaurav Kumar Patil, Rajesh Puri, Narendra S Choudhary, Saurabh R Patle, Zubin D Sharma, Randhir Sud
Background and aim:  There is paucity of data about endoscopic pancreatic sphincteroplasty (EPS) after endoscopic pancreatic sphincterotomy (EPST) in the treatment of chronic pancreatitis. The aim of this study was to establish the indications for EPS, complications related to it, and to examine its effectiveness in managing chronic pancreatitis after a year of follow-up. Methods:  We evaluated the safety and efficacy of pancreatic balloon dilation coupled with sphincterotomy for the treatment of chronic pancreatitis...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29216944/-prognostic-value-of-oxygen-challenge-test-for-patients-with-cardiogenic-shock-receiving-extracorporeal-membrane-oxygenation
#15
Liang Dong, Xiuhong Zhang, Fengming Liang, Xuan Yu, Ting Yang, Lang Li
OBJECTIVE: To investigate the prognostic value of oxygen challenge test (OCT) for patients with cardiogenic shock receiving extracorporeal membrane oxygenation (ECMO). METHODS: A retrospective analysis was conducted. Seventy-eight patients diagnosed with cardiogenic shock receiving veno-arterial (V-A) ECMO admitted to Department of intensive care unit (ICU) of Wuxi People's Hospital Affiliated to Nanjing Medical University from June 2012 to May 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216937/-significance-of-peripheral-perfusion-index-in-early-diagnosis-and-goal-directed-therapy-of-septic-shock-patients-a-prospective-single-blind-randomized-controlled-trial
#16
Yuanfeng Shi, Ruihong Yin, Yanli Wang, Jiguang Li, Xiaobing Chen, Yongpeng Xie, Caihong Gu, Xiuzhen Zou, Kexi Liu
OBJECTIVE: To investigate the application of peripheral perfusion index (PPI) in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock. METHODS: A prospective single-blind randomized controlled trial (RCT) was conducted. Adult patients with sepsis admitted to emergency medical department and intensive care unit (ICU) of the First People's Hospital of Lianyungang City in Jiangsu Province from January 2013 to December 2016 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216924/dengue-hemorrhagic-fever-complicated-with-acute-liver-failure-a-case-report
#17
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Dengue is a common arboviral infection with a clinically diverse spectrum of presentations. Although hepatic dysfunction is commonly identified in patients will dengue illness, acute liver failure is rare. The etiopathogenesis of hepatic dysfunction is multifactorial and related to direct viral invasion of hepatocytes, immunological factors and hypoxia particularly in cases of shock in dengue hemorrhagic fever. Ideal management of dengue-related hepatic dysfunction and acute liver failure is still debated...
December 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29214536/photonic-monitoring-of-treatment-during-infection-and-sepsis-development-of-new-detection-strategies-and-potential-clinical-applications
#18
REVIEW
Astrid Tannert, Anuradha Ramoji, Ute Neugebauer, Jürgen Popp
Despite the strong decline in the infection-associated mortality since the development of the first antibiotics, infectious diseases are still a major cause of death in the world. With the rising number of antibiotic-resistant pathogens, the incidence of deaths caused by infections may increase strongly in the future. Survival rates in sepsis, which occurs when body response to infections becomes uncontrolled, are still very poor if an adequate therapy is not initiated immediately. Therefore, approaches to monitor the treatment efficacy are crucially needed to adapt therapeutic strategies according to the patient's response...
December 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29212977/-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-complicated-by-concomitant-achromobacter-xylosoxidans-and-corynebacterium-striatum-bacteremia-following-allogeneic-hematopoietic-stem-cell-transplantation
#19
Yuta Katayama, Kouhei Kyo, Koji Iwato, Takeshi Okatani, Ryota Imanaka, Mitsuhiro Itagaki, Shinya Katsutani, Hideki Asaoku
A 54-year-old woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) underwent hematopoietic stem cell transplantation from an HLA-matched sibling. Subsequently, she suffered from chronic graft versus host disease (GvHD) and received medical treatment. Fever developed on day 697 and resulted in a shock state at 10 h after the visit. Achromobacter xylosoxidans was detected in the initial blood culture on day 699. General conditions exacerbated even after the start of meropenem hydrate (MEPM, Meropen®) administration, with Corynebacterium striatum detected as an additional species in the initial blood culture on day 701...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29212943/the-cellular-chaperone-heat-shock-protein-90-is-required-for-foot-and-mouth-disease-virus-capsid-precursor-processing-and-assembly-of-capsid-pentamers
#20
Joseph Newman, Amin S Asfor, Stephen Berryman, Terry Jackson, Stephen Curry, Tobias J Tuthill
Productive picornavirus infection requires the hijack of host cell pathways to aid with the different stages of virus entry, synthesis of the viral polyprotein and viral genome replication. Many picornaviruses, including foot-and-mouth disease virus (FMDV), assemble capsids via the multimerisation of several copies of a single capsid precursor protein into a pentameric subunit which further encapsidates the RNA. Pentamer formation is preceded by co- and post-translational modification of the capsid precursor (P1-2A) by viral and cellular enzymes, and the subsequent rearrangement of P1-2A into a structure amenable to pentamer formation...
December 6, 2017: Journal of Virology
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