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Age at menarche

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https://www.readbyqxmd.com/read/29789944/the-association-between-age-at-menarche-and-later-risk-of-gestational-diabetes-is-mediated-by-insulin-resistance
#1
Clive J Petry, Ken K Ong, Ieuan A Hughes, Carlo L Acerini, David B Dunger
AIMS: Associations have been reported between age at menarche and the later risk of gestational diabetes. However, it is not known whether these associations reflect differences in insulin sensitivity and/or pancreatic β-cell function in pregnancy. METHODS: We examined this question in women enrolled in the prospective Cambridge Baby Growth Study who recalled their age at menarche in questionnaires during pregnancy. Polynomial logistic and linear regression models were used to relate menarche timing to the risk of gestational diabetes, both unadjusted and adjusted for the Homeostasis Model Assessments of insulin resistance (HOMA IR) and pancreatic β-cell function (HOMA B) at week 28 of pregnancy...
May 22, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29785740/expression-levels-of-breast-cancer-related-gas5-and-lsinct5-lncrnas-in-cancer-free-breast-tissue-molecular-associations-with-age-at-menarche-and-obesity
#2
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Milad Bastami, Mohammad Mehdi Naghizadeh, Ziba Nariman-Saleh-Fam, Behnam Mansoori, Javad Tavakkoly-Bazzaz
Long noncoding RNAs (lncRNAs) constitute a major class of the human transcriptome which play crucial roles in the key biological processes of both normal and malignant breast cells. Although the aberrant expression of lncRNAs has been well-documented in breast cancer (BC), little is currently known about the association between their expression levels in the breast tissue of healthy women and BC risk factors, especially the reproductive or demographic characteristics that are among the most well-known BC risk modifiers...
May 21, 2018: Breast Journal
https://www.readbyqxmd.com/read/29783670/adult-premenopausal-bone-health-related-to-reproductive-characteristics-population-based-data-from-the-canadian-multicentre-osteoporosis-study-cam-os
#3
Azita Goshtasebi, Claudie Berger, Susan I Barr, Christopher S Kovacs, Tanveer Towheed, K Shawn Davison, Jerilynn C Prior
Amenorrhea is important for women's bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM os ) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29778786/body-weight-and-breast-cancer-nested-case-control-study-in-southern-brazil
#4
Natália Luiza Kops, Marina Bessel, Maira Caleffi, Rodrigo Antonini Ribeiro, Eliana Marcia Wendland
BACKGROUND: Current studies have shown that fast weight gain may be more important than body mass index on the incidence of breast cancer. The aim of this study was to evaluate the association between body weight and breast cancer. PATIENTS AND METHODS: This was a case-control study nested in a cohort of a breast cancer mammography screening program in Southern Brazil. A trained investigator administered a standardized interview to collect sociodemographic and clinical data, and body weight history (weight at menarche, at marriage, at first and last pregnancy, and at menopause)...
April 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#5
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#6
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29758276/age-of-menarche-in-a-longitudinal-us-cohort
#7
Frank M Biro, Ashley Pajak, Mary S Wolff, Susan M Pinney, Gayle C Windham, Maida P Galvez, Louise C Greenspan, Larry H Kushi, Susan L Teitelbaum
STUDY OBJECTIVES: Menarche is a critical milestone in a woman's life, and historically has been determined through several approaches. The goals of this study were to: 1) determine age at menarche from multiple reports of parents and adolescent participants in a prospective study; 2) examine factors impacting age at menarche; and 3) determine correlates of menarche and pubertal tempo. DESIGN: Longitudinal observational study. SETTING: Three sites of the Breast Cancer and the Environment Research Program...
May 11, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29751600/inflamed-phylloides-tumour-in-a-girl-a-challenging-diagnosis-in-paediatric-breast-lesions
#8
Ilaria Testa, Cristina Salvatori, Marco Prestipino, Maria Elena Laurenti, Paolo Gerli, Giuseppe Di Cara, Nicola Principi, Susanna Esposito, Mirko Bertozzi
Introduction : Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3⁻0.9% of all breast tumours. These tumours typically occur in women aged 30⁻70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation : A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29750056/is-age-at-menarche-associated-with-total-mortality-the-troms%C3%A3-study
#9
Marie Wasmuth Lundblad, Bjarne K Jacobsen
Purpose: Early age at menarche (AAM) has been associated with increased mortality and morbidity, including premature death from all causes, breast cancer and cardiovascular diseases. The aim of this study was to examine the association between AAM and all-cause mortality. Subjects and methods: A total of 12,409 women aged 25-94 years who took part in the fourth Tromsø Study in Norway during 1994-1995 were included in this prospective population-based study with a mean 18...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29725693/maternal-mortality-marital-status-and-bone-mineral-density-in-young-women-from-the-coimbra-identified-skeletal-collection
#10
Francisco Curate, Ana Tavares
In contemporary populations, pregnancy and lactation are usually followed by transient bone loss. The observation of reduced bone mass in young females from archaeological sites has sometimes been interpreted as an outcome of reproductive stress. In order to evaluate the overall effect of reproductive dynamics on bone mass in a historical skeletal sample, bone mineral density (BMD) at the proximal femur was assessed by dual-energy X-ray absorptiometry in 78 young women (17-39 years) from the Coimbra Identified Skeletal Collection...
May 3, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29715139/bone-mineral-density-as-a-potential-predictive-factor-for-luminal-type-breast-cancer-in-postmenopausal-women
#11
Franco Lumachi, Stefano M M Basso, Valentina Camozzi, Roberto Spaziante, Paolo Ubiali, Mario Ermani
BACKGROUND/AIM: We performed a case-control study to evaluate whether bone mineral density (BMD) can be considered a potential predictive factor for luminal-type breast cancer (BC), that could be useful in constructing a predictive risk model. MATERIALS AND METHODS: The medical records of 297 postmenopausal women with luminal-type node-negative BC who underwent lumbar-spine dual-energy X-ray absorptiometry (DXA) with BMD measurement before surgery, were analyzed and compared with those of 297 age-matched randomly selected healthy controls...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29706142/prenatal-lead-exposure-in-relation-to-age-at-menarche-results-from-a-longitudinal-study-in-mexico-city
#12
E C Jansen, L Zhou, P X K Song, B N Sánchez, A Mercado, H Hu, M Solano, K E Peterson, M M Tellez-Rojo
Animal and cross-sectional epidemiological studies suggest that prenatal lead exposure is related to delayed menarche, but this has not been confirmed in longitudinal studies. We analyzed this association among 200 girls from Mexico City who were followed since the first trimester of gestation. Maternal blood lead levels were analyzed once during each trimester of pregnancy, and daughters were asked about their first menstrual cycle at a visit between the ages of 9.8 and 18.1 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) for probability of menarche over the follow-up period using interval-censored Cox models, comparing those with prenatal blood lead level ⩾5 µg/dl to those with prenatal blood lead <5 µg/dl...
April 30, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29704753/does-exposure-to-pm-10-decrease-age-at-menarche
#13
Eun Mi Jung, Hae Soon Kim, Hyesook Park, Shinhee Ye, Dongheon Lee, Eun Hee Ha
BACKGROUND: There has been a consistent decrease in age at menarche in South Korea. A potential risk factor for early menarche is exposure to particulate matter (PM), because endocrine-disrupting compounds emitted into air from anthropogenic sources may be incorporated into PM. The objective of this study was to examine the association between pre-menarcheal exposure to PM ≤ 10 μm in diameter (PM10 ) and age at menarche in adolescents of South Korea using Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2012 data...
April 25, 2018: Environment International
https://www.readbyqxmd.com/read/29697830/menstrual-dysfunction-in-girls-from-the-treatment-options-for-type-2-diabetes-in-adolescents-and-youth-today-study
#14
Megan M Kelsey, Barbara H Braffett, Mitchell E Geffner, Lynne L Levitsky, Sonia Caprio, Siripoom V McKay, Rachana Shah, Jennifer E Sprague, Silva A Arslanian
Context: Little is known about reproductive function in girls with youth-onset type 2 diabetes. Objectives: To characterize girls with irregular menses, and effects of glycemic treatments on menses and sex steroids in the Treatment Options for Type 2 Diabetes in Youth (TODAY) study. Design: Differences in demographic, metabolic, and hormonal characteristics between regular vs. irregular menses groups were tested; treatment group (metformin +/- rosiglitazone, metformin + lifestyle) effect on menses and sex steroids over time in the study was assessed...
April 24, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29696756/female-reproductive-history-and-risk-of-type-2-diabetes-a-prospective-analysis-of-126-721-women
#15
Nirmala Pandeya, Rachel R Huxley, Hsin-Fang Chung, Annette J Dobson, Diana Kuh, Rebecca Hardy, Janet E Cade, Darren C Greenwood, Graham G Giles, Fiona Bruinsma, Panayotes Demakakos, Mette Kildevaeld Simonsen, Hans-Olov Adami, Elisabete Weiderpass, Gita D Mishra
AIMS: Female reproductive history has been inconsistently associated with risk of type 2 diabetes. We examined the prospective associations between aspects of a woman's reproductive history and incident diabetes. METHODS: This study pooled 126,721 middle-aged women's individual data from eight cohort studies contributing to the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE). Associations between age at menarche, age at first birth, parity and menopausal status with incident diabetes were examined using generalized linear mixed models with binomial distribution and robust variance...
April 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29682210/age-at-menarche-and-risks-of-gestational-diabetes-mellitus-a-meta-analysis-of-prospective-studies
#16
Ya Xiao, Ruixue Chen, Minghao Chen, Anling Luo, Dayi Chen, Qiuer Liang, Yunfei Cai, Liguo Chen, Xiaoshan Zhao
Background: Accumulating evidence suggests that early menarche is associated with adult obesity, which in turn may increase the risk of insulin resistance and hyperglycemia. However, the relation of menarcheal age with gestational diabetes mellitus (GDM) remains inconsistent across studies. The objective of this meta-analysis was to evaluate the association between age at menarche and GDM risk. Materials and Methods: We searched Medline (PubMed), Embase, Web of Knowledge and the Cochrane library through the end of May 2017...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#17
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29675261/growth-trajectory-and-pubertal-tempo-from-birth-till-final-height-in-a-girl-with-wolf-hirschhorn-syndrome
#18
Jia Xuan Siew, Fabian Yap
Growth anomaly is a prominent feature in Wolf-Hirschhorn syndrome (WHS), a rare congenital disorder caused by variable deletion of chromosome 4p. While growth charts have been developed for WHS patients 0-4 years of age and growth data available for Japanese WHS patients 0-17 years, information on pubertal growth and final height among WHS children remain lacking. Growth hormone (GH) therapy has been reported in two GH-sufficient children with WHS, allowing for pre-puberty catch up growth; however, pubertal growth and final height information was also unavailable...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29673111/comparison-of-epidemiological-features-clinicopathological-features-and-treatments-between-premenopausal-and-postmenopausal-female-breast-cancer-patients-in-western-china-a-retrospective-multicenter-study-of-15-389-female-patients
#19
REVIEW
Fan Feng, Yuxian Wei, Ke Zheng, Yujing Li, Lu Zhang, Tielin Wang, Yanli Zhang, Hongyuan Li, Guosheng Ren, Fan Li
Premenopausal and postmenopausal breast cancers are considered different types. Thus, this study aimed to explore differences in risk factors, epidemiological features, clinicopathological features, and treatment modes of premenopausal breast cancer compared to postmenopausal patients in western China. This was a hospital-based, retrospective, multicenter epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group database, we obtained the records of 15,389 female breast cancers between January 2010 and April 2017...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29673014/association-of-primary-dysmenorrhea-with-anthropometrical-and-socio-economic-factors-in-polish-university-students
#20
Martyna Zurawiecka, Iwona Wronka
AIMS: To examine the prevalence and factors correlated with primary dysmenorrhea in young female subjects. METHODS: Cross-sectional research was conducted among 1305 female university students aged 19-25 years. The following measurements were taken: height, body mass, waist circumference, hip circumference, the length of index and ring finger. A questionnaire was used to obtain information on menstrual pains, the characteristics of the menstrual cycles (regularity, duration), the number of the days of menstrual bleeding, age at menarche, overall health and socio-economic status of the subjects...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
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