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Glucose dopamine

Xia Zhou, Liying Ren, Zhiling Yu, Xiaoqian Huang, Yuhao Li, Chunxia Wang
Cumulative evidence has suggested that many antipsychotics cause metabolic abnormalities. Adipose tissue insulin resistance (Adipo-IR) contributes to the development and progress of metabolic abnormalities including fatty liver by inducing excessive free fatty acid release from adipose tissue. Sulpiride is an old antipsychotic still frequently used in many developing countries. However, its adverse metabolic effects remain poorly understood. Here, chronic administration of sulpiride (80 mg/kg, subcutaneously, once daily for 6 weeks) elevated fasting insulin concentration and the index of the homeostasis model assessment of insulin resistance in rats...
March 15, 2018: Toxicology and Applied Pharmacology
A Abellán-Llobregat, C González-Gaitán, L Vidal, A Canals, E Morallón
A new portable electrochemical sensor based on 4-aminobenzoic acid-modified herringbone carbon nanotubes (hCNTs-4ABA/Au-IDA) has been developed for the simultaneous determination of ascorbic acid (AA) and uric acid (UA) in physiological fluids. AA and UA were quantified by chronoamperometry at 0.1 and 0.32 V, respectively, in phosphate buffer solution (PBS 0.25 M, pH 7.0). Significant results were obtained for the separate quantification of AA and UA, with a limit of detection (LOD) of 0.65 μM for both analytes, and sensitivities of (9...
February 23, 2018: Biosensors & Bioelectronics
Xiaohai Liu, Yang Liu, Jun Gao, Ming Feng, Xinjie Bao, Kan Deng, Yong Yao, Renzhi Wang
BACKGROUND: Prolactinomas are the most common functional pituitary adenomas, and dopamine agonists (DAs) are the primary therapy. However, some patients are resistant to DAs. Recently, metformin has been proposed as a cancer treatment. CASE DESCRIPTION: This study is a retrospective review of two cases, including one patient with prolactinoma who was resistant to bromocriptine, diagnosed with impaired glucose tolerance and administered metformin. Surprisingly, combining the patient's treatment with metformin decreased prolactin (PRL) levels to 12 ng/ml and had significantly decreased the size of the tumor after one year of combination therapy...
March 9, 2018: World Neurosurgery
Kelly A Mitok, Elyse C Freiberger, Kathryn L Schueler, Mary E Rabaglia, Donald S Stapleton, Nicholas W Kwiecien, Paige A Malec, Alexander S Hebert, Aimee T Broman, Robert T Kennedy, Mark P Keller, Joshua J Coon, Alan D Attie
The mouse is a critical model in diabetes research, but most research in mice has been limited to a small number of mouse strains and limited genetic variation. We used the eight founder strains of the Collaborative Cross (CC) (C57BL/6J (B6), A/J, 129S1/SvImJ (129), NOD/ShiLtJ (NOD), NZO/HILtJ (NZO), PWK/PhJ (PWK), WSB/EiJ (WSB), CAST/EiJ (CAST)) to investigate the genetic dependence of diabetes-related metabolic phenotypes and insulin secretion. We found that strain background is associated with an extraordinary range in body weight, plasma glucose, insulin, and triglycerides, and insulin secretion...
March 1, 2018: Journal of Biological Chemistry
Kishore Kumar, Madhavi Biyyam, Bharat Bajantri, Sureshkumar Nayudu
Calcium channel blocker (CCB ) overdose, whether intentional or accidental, is a common clinical scenario and can be very lethal. Conventional treatments for CCB overdose include intravenous (IV) fluids, calcium salts, dopamine, dobutamine, norepinephrine, phosphodiesterase inhibitors, and glucagon. However, the conventional therapies are unsuccessful in reversing the cardiovascular toxicity of CCB, so they commonly fail to improve the hemodynamic condition of the patient. Blockade of the L-type calcium channels that mediate the antihypertensive effect of CCBs also decreases the release of insulin from pancreatic β-islet cells and reduces glucose uptake by tissues (insulin resistance)...
February 2018: Cardiology Research
G Nagesh Babu, Manjeet Gupta, Vimal K Paliwal, Suruchi Singh, Tanushri Chatterji, Raja Roy
BACKGROUND: Parkinson's disease (PD) is the result of progressive degeneration of the nigrostriatal dopaminergic pathway and depletion of neurotransmitter dopamine in the striatum. METHODS: We included 17 patients with PD along with 7 patients of progressive supranuclear palsy (PSP), 6 patients of multiple system atrophy (MSA) and 22 age and sex-matched healthy controls. We analyzed metabolite profiles in the serum of these patients and controls using1 H NMR spectroscopy...
February 20, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Jiali Li, Luting Yan
Polydopamine (PDA) film coatings are multifunctional substances because these coatings can adhere to nearly all known solid materials. The self-polymerization of dopamine in aqueous solution was investigated in this study; PDA films are an effective platform for further functionalization similar to the reduction of silver ions into silver nanoparticles (NPs). The films provide a new method to attach metal NPs on substrates. Through this simple method, glucose sensors based on this kind of Ag NPs/ITO exhibited a detection limit of about 10 μM and presented a good sensitivity enough for real use (3-8 mM)...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Marcello Casa, Maria Sarno, Rosalba Liguori, Claudia Cirillo, Alfredo Rubino, Emanuele Bezzeccheri, Johan Liu, Paolo Ciambelli
Decoration with silver nanoparticles was obtained by coating graphene with a polydopamine layer, able to induce spontaneous metallic nanoparticles formation without any specific chemical interfacial modifier, neither using complex instrumentation. The choice of dopamine was inspired by the composition of adhesive proteins in mussels, related to their robust attach to solid surfaces. The synthesis procedure started from graphite and involved eco-friendly compounds, such as Vitamin C and glucose as reducing agent and water as reaction medium...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Andy Forbes, Mary Hobart, John Ouyang, Lily Shi, Stephanie Pfister, Mika Hakala
Background: Brexpiprazole is a serotonin-dopamine activity modulator with efficacy in acute schizophrenia and relapse prevention. The aim of this Phase 3, multicenter study was to assess the long-term safety, tolerability, and efficacy of treatment with brexpiprazole flexible-dose 1-4 mg/day. Methods: Patients rolled over into this 52-week open-label study (amended to 26 weeks towards the end) from three randomized, double-blind, placebo-controlled Phase 3 studies...
February 3, 2018: International Journal of Neuropsychopharmacology
Abdulazeez T Lawal
This review discusses recent graphene (GR) electrochemical biosensor for accurate detection of biomolecules, including glucose, hydrogen peroxide, dopamine, ascorbic acid, uric acid, nicotinamide adenine dinucleotide, DNA, metals and immunosensor through effective immobilization of enzymes, including glucose oxidase, horseradish peroxidase, and haemoglobin. GR-based biosensors exhibited remarkable performance with high sensitivities, wide linear detection ranges, low detection limits, and long-term stabilities...
January 31, 2018: Biosensors & Bioelectronics
Meera Punjiya, Chung Hee Moon, Zimple Matharu, Hojatollah Rezaei Nejad, Sameer Sonkusale
Paper-based microfluidic devices with screen-printed electrodes (SPEs) for electrochemical sensing are popular for low-cost point-of-care diagnostics. The electroactive sensing area in these devices is always the irregular, bottom-SPE surface which is in contact with the analyte flowing within the paper substrate. Unfortunately, this results in an electroactive area which varies widely from sensor to sensor. In this paper, we present a three-dimensional paper-based analytical device with a hollow 3D fluid reservoir which allows for use of a more uniform top-SPE surface as the electroactive sensing area...
February 7, 2018: Analyst
Satoshi Honda, Toshiyuki Nagai, Kunihiro Nishimura, Michikazu Nakai, Yasuyuki Honda, Hiroki Nakano, Naotsugu Iwakami, Yasuo Sugano, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Hiroyuki Yokoyama, Hisao Ogawa, Satoshi Yasuda, Toshihisa Anzai
BACKGROUND: Lower urinary sodium concentration (UNa) may reflect impaired renal perfusion, higher neurohormonal activity and diuretic resistance. However, the prognostic impact of UNa in patients with acute heart failure (AHF) has not been fully elucidated. METHODS: We investigate the association between UNa and clinical outcomes in 669 patients admitted with AHF in our prospective registry. Patients were stratified into tertiles based on UNa in a spot urine sample on admission...
March 1, 2018: International Journal of Cardiology
Shin J Lee, Anne J Jokiaho, Graciela Sanchez-Watts, Alan G Watts
Hindbrain catecholamine neurons convey gut-derived metabolic signals to an interconnected neuronal network in the hypothalamus and adjacent forebrain. They are critical for short-term glycemic control, glucocorticoid and glucoprivic feeding responses, and GLP-1 signaling. Here we investigate whether these pathways also contribute to long-term energy homeostasis by controlling obesogenic sensitivity to a high-fat, high sucrose choice diet (HFSC). We ablated hindbrain-originating catecholaminergic projections by injecting anti-dopamine-β-hydroxylase-conjugated saporin (DSAP) into the paraventricular nucleus of the hypothalamus (PVH) of male rats fed a chow diet for up to 12 weeks or a HFSC for 8 weeks...
January 31, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jose I Juncosa, Kenji Takaya, Hoang V Le, Matthew J Moschitto, Pathum M Weerawarna, Romila Mascarenhas, Dali Liu, Stephen L Dewey, Richard B Silverman
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as a possible strategy for the treatment of substance abuse. The raised GABA levels that occur as a consequence of this inhibition have been found to antagonize the rapid release of dopamine in the ventral striatum (nucleus accumbens) that follows an acute challenge by an addictive substance...
January 30, 2018: Journal of the American Chemical Society
Tetsuro Ishii, Eiji Warabi, Giovanni E Mann
Circadian clock genes regulate energy metabolism partly through neurotrophins in the body. The low affinity neurotrophin receptor p75NTR is a clock component directly regulated by the transcriptional factor Clock:Bmal1 complex. Brain-derived neurotrophic factor (BDNF) is expressed in the brain and plays a key role in coordinating metabolic interactions between neurons and astrocytes. BDNF transduces signals through TrkB and p75NTR receptors. This review highlights a novel molecular mechanism by which BDNF via circadian control of p75NTR leads to daily resetting of glucose and glycogen metabolism in brain astrocytes to accommodate their functional interaction with neurons...
January 24, 2018: Free Radical Biology & Medicine
Audrey Yule Coqueiro, Raquel Raizel, Andrea Bonvini, Thaís Hypólito, Allan da Mata Godois, Jéssica Ramos Rocha Pereira, Amanda Beatriz de Oliveira Garcia, Rafael de Souza Bittencourt Lara, Marcelo Macedo Rogero, Julio Tirapegui
Recent evidence suggests that increased brain serotonin synthesis impairs performance in high-intensity intermittent exercise and specific amino acids may modulate this condition, delaying fatigue. This study investigated the effects of glutamine and alanine supplementation on central fatigue markers in rats submitted to resistance training (RT). Wistar rats were distributed in: sedentary (SED), trained (CON), trained and supplemented with alanine (ALA), glutamine and alanine in their free form (G + A), or as dipeptide (DIP)...
January 25, 2018: Nutrients
Chonlaphat Sukasem, Natchaya Vanwong, Pornpen Srisawasdi, Nattawat Ngamsamut, Nopphadol Nuntamool, Yaowaluck Hongkaew, Apichaya Puangpetch, Bhunnada Chamkrachangpada, Penkhae Limsila
The purpose of this study was to explore the association of genetic polymorphism of genes related to pharmacokinetics or pharmacodynamics with insulin resistance in children and adolescents with autism spectrum disorder (ASD) and treated with risperidone. All 89 subjects underwent measurement of fasting blood glucose and insulin levels, body weight and height. Genotyping was performed by Taqman real-time polymerase chain reaction (PCR) (pharmacokinetics genes: cytochrome P450 2D6 (CYP2D6) *4 (rs3892097), *5 (gene deletion), *10 (rs1065852), and *41 (rs28371725), ATP-binding cassette transporter B1 (ABCB1) 2677 G>T/A (rs2032582) and 3435C>T (rs1045642), and pharmacodynamics genes: dopamine receptor D2 (DRD2) Tag-SNP (C>T) (rs4436578), DRD2 Tag1A (C>T) (rs1800497), leptin gene (LEP) -2548G>A (rs7799039), ghrelin gene (GHRL) -604G>A (rs27647), and brain-derived neurotrophic factor (BDNF) 196G>A (rs6265)...
January 25, 2018: Basic & Clinical Pharmacology & Toxicology
Nabanita Pal, Sangam Banerjee, Asim Bhaumik
In modern world, diabetes is one of the most leading diseases that cause human death and disability. Continuous effort to control and manage diabetes by acute monitoring of the blood glucose concentration requires the development of an efficient and reliable glucose sensing device. Although both enzymatic and enzyme-free methods of glucose detection are available in the market, non-enzymatic biosensors are more significant due to certain drawbacks in enzyme based sensors. In this article, a stable non-enzymatic sensing platform for d-glucose based on nickel hydroxide and nickel oxide nanomaterials has been described...
January 9, 2018: Journal of Colloid and Interface Science
Suryakant Mishra, Priyanka Yogi, P R Sagdeo, Rajesh Kumar
Glucose sensing properties of mesoporous well-aligned, dense nickel oxide (NiO) nanostructures (NSs) in nanopetals (NPs) shape grown hydrothermally on the FTO-coated glass substrate has been demonstrated. The structural study based investigations of NiO-NPs has been carried out by X-ray diffraction (XRD), electron and atomic force microscopies, energy dispersive X-ray (EDX), and X-ray photospectroscopy (XPS). Brunauer-Emmett-Teller (BET) measurements, employed for surface analysis, suggest NiO's suitability for surface activity based glucose sensing applications...
January 11, 2018: Nanoscale Research Letters
Samantha K Smith, Leyda Z Lugo-Morales, Christina Tang, Saahj P Gosrani, Christie A Lee, James G Roberts, Stephen W Morton, Gregory S McCarty, Saad A Khan, Leslie A Sombers
Electrochemical monitoring of non-electroactive species requires a biosensor that is stable and selective, with sensitivity to physiological concentrations of targeted analytes. We have combined glucose oxidase-modified carbon-fiber microelectrodes with fast-scan cyclic voltammetry for real-time measurements of glucose fluctuations in brain tissue. Work presented herein quantitatively compares three approaches to enzyme immobilization on the microelectrode surface - physical adsorption, hydrogel entrapment, and entrapment in electrospun nanofibers...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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