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Glucose dopamine

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https://www.readbyqxmd.com/read/29327092/mesoporous-nickel-oxide-nio-nanopetals-for-ultrasensitive-glucose-sensing
#1
Suryakant Mishra, Priyanka Yogi, P R Sagdeo, Rajesh Kumar
Glucose sensing properties of mesoporous well-aligned, dense nickel oxide (NiO) nanostructures (NSs) in nanopetals (NPs) shape grown hydrothermally on the FTO-coated glass substrate has been demonstrated. The structural study based investigations of NiO-NPs has been carried out by X-ray diffraction (XRD), electron and atomic force microscopies, energy dispersive X-ray (EDX), and X-ray photospectroscopy (XPS). Brunauer-Emmett-Teller (BET) measurements, employed for surface analysis, suggest NiO's suitability for surface activity based glucose sensing applications...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29316144/quantitative-comparison-of-enzyme-immobilization-strategies-for-glucose-biosensing-in-real-time-using-fast-scan-cyclic-voltammetry-coupled-with-carbon-fiber-microelectrodes
#2
Samantha K Smith, Leyda Z Lugo-Morales, Christina Tang, Saahj P Gosrani, Christie A Lee, James G Roberts, Stephen W Morton, Gregory S McCarty, Saad A Khan, Leslie A Sombers
Electrochemical monitoring of non-electroactive species requires a biosensor that is stable and selective, with sensitivity to physiological concentrations of targeted analytes. We have combined glucose oxidase-modified carbon-fiber microelectrodes with fast-scan cyclic voltammetry for real-time measurements of glucose fluctuations in brain tissue. Work presented herein quantitatively compares three approaches to enzyme immobilization on the microelectrode surface - physical adsorption, hydrogel entrapment, and entrapment in electrospun nanofibers...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29306964/higher-schizotypy-predicts-better-metabolic-profile-in-unaffected-siblings-of-patients-with-schizophrenia
#3
E Cem Atbasoglu, Guvem Gumus-Akay, Sinan Guloksuz, Meram Can Saka, Alp Ucok, Koksal Alptekin, Sevim Gullu, Jim van Os
RATIONALE: Type 2 diabetes (T2D) is more frequent in schizophrenia (Sz) than in the general population. This association is partly accounted for by shared susceptibility genetic variants. OBJECTIVE: We tested the hypotheses that a genetic predisposition to Sz would be associated with higher likelihood of insulin resistance (IR), and that IR would be predicted by subthreshold psychosis phenotypes. METHODS: Unaffected siblings of Sz patients (n = 101) were compared with a nonclinical sample (n = 305) in terms of IR, schizotypy (SzTy), and a behavioural experiment of "jumping to conclusions"...
January 6, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29305987/l-3-4-dihydroxyphenylalanine-l-dopa-induces-neuroendocrinological-physiological-and-immunological-regulation-in-white-shrimp-litopenaeus-vannamei
#4
Ratchaneegorn Mapanao, Hsin-Wei Kuo, Chin-Chuan Chang, Kuan-Fu Liu, Winton Cheng
L-3,4-Dihydroxyphenylalanine (l-DOPA) is a precursor for dopamine (DA) synthesis. Assessments were conducted to analyze the effects of l-DOPA on mediating regulation of neuroendocrinological, immunological, and physiological parameters in the shrimp, Litopenaeus vannamei when they were individually injected with 0.01 N HCl or l-DOPA at 0.5 or 1.0 μmol shrimp-1 for 60, 120, and 240 min. For catecholamine synthesis evaluation, tyrosine hydroxylase (TH) and DA beta hydroxylase (DBH) activities, l-DOPA, DA, and norepinephrine (NE) levels in hemolymph were determined...
January 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29305082/hyperglycemic-chorea-ballism-ascertained-over-15-years-at-a-referral-medical-center
#5
Conor Ryan, J Eric Ahlskog, Rodolfo Savica
OBJECTIVE: To describe chorea/ballism triggered by a hyperglycemic event. METHODS: We used the electronic records system at Mayo Clinic-Rochester to identify patients diagnosed with chorea or ballism from January 1st, 2000 through December 31st, 2014. Each record was reviewed to confirm chorea/ballism. From these cases we selected those that developed chorea/ballism within a month after a hyperglycemic episode (blood glucose >300 mg/dL). Clinical, laboratory, and imaging findings were analyzed...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29295587/dopamine-and-levodopa-prodrugs-for-the-treatment-of-parkinson-s-disease
#6
REVIEW
Fatma Haddad, Maryam Sawalha, Yahya Khawaja, Anas Najjar, Rafik Karaman
Background: Parkinson's disease is an aggressive and progressive neurodegenerative disorder that depletes dopamine (DA) in the central nervous system. Dopamine replacement therapy, mainly through actual dopamine and its original prodrug l-dopa (LD), faces many challenges such as poor blood brain barrier penetration and decreased response to therapy with time. Methods: The prodrugs described herein are ester, amide, dimeric amide, carrier-mediated, peptide transport-mediated, cyclic, chemical delivery systems and enzyme-models prodrugs designed and made by chemical means, and their bioavailability was studied in animals...
December 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29291105/nanostructured-carbon-electrode-modified-with-n-doped-graphene-quantum-dots-chitosan-nanocomposite-a-sensitive-electrochemical-dopamine-sensor
#7
Sami Ben Aoun
A highly selective and sensitive dopamine electrochemical sensor based on nitrogen-doped graphene quantum dots-chitosan nanocomposite-modified nanostructured screen printed carbon electrode is presented, for the first time. Graphene quantum dots were prepared via microwave-assisted hydrothermal reaction of glucose, and nitrogen doping was realized by introducing ammonia in the reaction mixture. Chitosan incorporation played a significant role towards the selectivity of the prepared sensor by hindering the ascorbic acid interference and enlarging the peak potential separation between dopamine and uric acid...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29289718/a-high-fat-high-sugar-western-diet-alters-dorsal-striatal-glutamate-opioid-and-dopamine-transmission-in-mice
#8
Brandon M Fritz, Braulio Muñoz, Fuqin Yin, Casey Bauchle, Brady K Atwood
Understanding neuroadaptations involved in obesity is critical for developing new approaches to treatment. Diet-induced neuroadaptations within the dorsal striatum have the capacity to drive excessive food seeking and consumption. Five week old C57BL/6J mice consumed a high-fat, high-sugar 'western diet' (WD) or a control 'standard diet' (SD) for 16 weeks. Weight gain, glucose tolerance, and insulin tolerance were measured to confirm an obese-like state. Following these 16 weeks, electrophysiological recordings were made from medium spiny neurons (MSNs) in the medial (DMS) and lateral (DLS) portions of dorsal striatum to evaluate diet effects on neuronal excitability and synaptic plasticity...
December 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/29287121/high-fructose-corn-syrup-induces-metabolic-dysregulation-and-altered-dopamine-signaling-in-the-absence-of-obesity
#9
Allison M Meyers, Devry Mourra, Jeff A Beeler
The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity, independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely accepted as a rodent model of diet-induced obesity (DIO) and metabolic disorder, the value of HFCS alone as a rodent model of DIO is unclear. Impaired dopamine function is associated with obesity and high fat diet, but the effect of HFCS on the dopamine system has not been investigated. The objective of this study was to test the effect of HFCS on weight gain, glucose regulation, and evoked dopamine release using fast-scan cyclic voltammetry...
2017: PloS One
https://www.readbyqxmd.com/read/29260546/polydopamine-coated-magnetic-molecularly-imprinted-polymers-with-fragment-template-for-identification-of-pulsatilla-saponins-metabolites-in-rat-feces-with-uplc-q-tof-ms
#10
Yuzhen Zhang, Jia-Wei Zhang, Chong-Zhi Wang, Lian-Di Zhou, Qihui Zhang, Chun-Su Yuan
In this work, a modified pretreatment method using magnetic molecularly imprinted polymers (MMIPs) was successfully applied to study the metabolites of an important botanical with ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). The MMIPs for glucoside-specific adsorption was used to identify metabolites of Pulsatilla chinensis in rat feces. Polymers were prepared by using Fe3O4 nanoparticles as the supporting matrix, D-glucose as fragment template and dopamine as the functional monomer and cross-linker...
December 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29240779/impact-of-maternal-high-fat-diet-on-hypothalamic-transcriptome-in-neonatal-sprague-dawley-rats
#11
Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitage
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window...
2017: PloS One
https://www.readbyqxmd.com/read/29231773/molecular-imaging-of-autism-spectrum-disorder
#12
Brian Jaeho Hwang, Mona Adel Mohamed, James Robert Brašić
Autism spectrum disorder (ASD) is a condition with onset in early childhood characterized by marked deficits in interpersonal interactions and communication and by a restricted and repetitive range of interests and activities. This review points out key recent findings utilizing molecular imaging including magnetic resonance spectroscopy (MRS) and nuclear neuroimaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). MRS indicates an excitatory/inhibitory imbalance in high-functioning autism...
December 12, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/29225702/the-influence-of-dopamine-beta-hydroxylase-and-catechol-o-methyltransferase-gene-polymorphism-on-the-efficacy-of-insulin-detemir-therapy-in-patients-with-type-2-diabetes-mellitus
#13
Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F Outeiro, Nela Pivac, Fran Borovecki
Background: Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported that insulin detemir is an efficient long-acting insulin with a weight sparing effect. The aim of this study was to determine the association of catechol O-methyltransferase (COMT) Val108/158Met and dopamine-beta-hydroxylase (DBH) 1021C/T polymorphisms with the effectiveness of insulin detemir in achieving glucose control and body weight control...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29205812/cu2-modified-metal-organic-framework-nanoparticles-a-peroxidase-mimicking-nanoenzyme
#14
Wei-Hai Chen, Margarita Vázquez-González, Anna Kozell, Alessandro Cecconello, Itamar Willner
The synthesis and characterization of UiO-type metal-organic framework nanoparticles (NMOFs) composed of Zr4+ ions bridged by 2,2'-bipyridine-5,5'-dicarboxylic acid ligands and the postmodification of the NMOFs with Cu2+ ions are described. The resulting Cu2+ -modified NMOFs, Cu2+ -NMOFs, exhibit peroxidase-like catalytic activities reflected by the catalyzed oxidation of Amplex-Red to the fluorescent Resorufin by H2 O2 , the catalyzed oxidation of dopamine to aminochrome by H2 O2 , and the catalyzed generation of chemiluminescence in the presence of luminol/H2 O2 ...
December 4, 2017: Small
https://www.readbyqxmd.com/read/29189347/the-glucagon-like-peptide-1-analog-exenatide-increases-blood-glucose-clearance-lactate-clearance-and-heart-rate-in-comatose-patients-after-out-of-hospital-cardiac-arrest
#15
Sebastian Wiberg, Jesper Kjaergaard, Henrik Schmidt, Jakob Hartvig Thomsen, Martin Frydland, Matilde Winther-Jensen, Matias Greve Lindholm, Dan Eik Høfsten, Thomas Engstrøm, Lars Køber, Jacob Eifer Møller, Christian Hassager
OBJECTIVES: To investigate the effects of the glucagon-like peptide-1 analog exenatide on blood glucose, lactate clearance, and hemodynamic variables in comatose, resuscitated out-of-hospital cardiac arrest patients. DESIGN: Predefined post hoc analyzes from a double-blind, randomized clinical trial. SETTING: The ICU of a tertiary heart center. PATIENTS: Consecutive sample of adult, comatose patients undergoing targeted temperature management after out-of-hospital cardiac arrest from a presumed cardiac cause, irrespective of the initial cardiac rhythm...
November 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29187664/-clinical-characteristics-of-hemichorea-associated-with-non-ketotic-hyperglycemia-in-3-patients-case-report-and-literature-review
#16
Yacen Hu, Yafang Zhou, Fang Yi, Lingyan Yao, Hongwei Xu, Lin Zhou
To investigate the pathophysiology, clinical manifestation and neuroimaging characteristics and therapeutic experiences for hemichore associated with non-ketotic hyperglycemia (HC-NH).
 Methods: Clinical data of three patients with HC-NH from Xiangya Hospital, Central South University were analyzed retrospectively, and the related literature was reviewed.
 Results: The core clinical features of HC-NH were characterized by acute/subacute onset of hemichorea with non-ketotic hyperglycemia in the elderly females...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29185338/a-universal-multifunctional-nanoplatform-based-on-the-target-induced-in-situ-promoting-au-seeds-growth-to-quench-fluorescence-of-upconversion-nanoparticles
#17
Qiongqiong Wu, Hongyu Chen, Aijin Fang, Xinyang Wu, Meiling Liu, Haitao Li, Youyu Zhang, Shouzhuo Yao
Construction of newly multifunctional chem/biosensing platform for small biomolecules and tumor markers is of great importance in analytical chemistry. Herein, a novel universal multifunctional nanoplatform for biomolecules and enzyme activity detection was proposed based on fluorescence resonance energy transfer (FRET) between upconversion nanoparticles (UCNPs) and the target-inducing enlarged gold nanoparticles (AuNPs). The reductive molecule such as H2O2, can act as the reductant to reduce HAuCl4, which will make the Au seeds grow...
November 29, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29166705/comprehensive-analysis-of-nine-monoamines-and-metabolites-in-small-amounts-of-peripheral-murine-c57bl-6j-tissues
#18
Joachim Nagler, Sonja C Schriever, Meri De Angelis, Paul T Pfluger, Karl-Werner Schramm
Monoamines, acting as hormones and neurotransmitters, play a critical role in multiple physiological processes ranging from cognitive function and mood to sympathetic nervous system activity, fight-or-flight response, or glucose homeostasis. In addition to brain and blood, monoamines are abundant in several tissues, and dysfunction in their synthesis or signaling is associated with various pathological conditions. It was our goal to develop a method to detect these compounds in peripheral murine tissues. In this study, we employed a high performance liquid chromatography method using electrochemical detection that allows not only detecting the catecholamines but a detailed analysis of nine monoamines and metabolites in murine tissues...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29158252/food-addiction-high-glycemic-index-carbohydrates-and-obesity
#19
REVIEW
Belinda Lennerz, Jochen K Lennerz
BACKGROUND: Treatment success in obesity remains low, and recently food addiction has been delineated as an underlying etiologic factor with therapeutic relevance. Specifically, current treatment focuses on reduced food intake and increase of physical activity, whereas interventions for addiction encompass behavioral therapy, abstinence, and environmental interventions such as taxation, restrictions on advertising, and regulation of school menus. CONTENT: Here, we reviewed the pertinent literature on food addiction with a specific focus on the role of high-glycemic-index carbohydrates in triggering addictive symptoms...
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29089444/pre-synaptic-regulation-of-leptin-in-a-defined-lateral-hypothalamus-ventral-tegmental-area-neurocircuitry-depends-on-energy-state
#20
Jing-Jing Liu, Nicholas T Bello, Zhiping P Pang
Synaptic transmission controls information flow in the brain and expression of all brain-related behaviors, including food intake. Leptin, an adipocyte-derived hormone, acts on neurons located in the lateral hypothalamus (LHA) to maintain energy homeostasis and regulate food intake behavior. The specific synaptic mechanisms, cell types and neural projections mediating this effect remain unclear. In male mice, using pathway-specific retrograde tracing, whole cell patch clamp recordings and posthoc cell type identification, we found that leptin reduces excitatory synaptic strength onto both melanin-concentrating hormone (MCH) and orexin-expressing neurons projecting from the LHA to the ventral tegmental area (VTA), which may affect dopamine signaling and motivation for feeding...
October 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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