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pseudoexfoliation

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https://www.readbyqxmd.com/read/29225964/chosen-vascular-risk-markers-in-pseudoexfoliation-syndrome-an-age-related-disorder
#1
Hanna Lesiewska, Agnieszka Łukaszewska-Smyk, Grażyna Odrowąż-Sypniewska, Magdalena Krintus, Aneta Mańkowska-Cyl, Grażyna Malukiewicz
Purpose: To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods: 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results: There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29200083/clinical-outcomes-and-intraocular-pressure-control-after-scleral-glued-intraocular-lens-insertion-in-eyes-with-pseudoexfoliation
#2
Ashwinee Ragam, David C Ritterband, Emily C Waisbren, Julia Mathew-Padiyedathu, Joann Kang, John A Seedor
PURPOSE: To analyze clinical outcomes and intraocular pressure (IOP) control following scleral-glued intraocular lens (IOL) fixation in eyes with pseudoexfoliation (PXF). METHODS: A retrospective chart review and outcome analysis was performed on a series of eyes undergoing glue-assisted, scleral-fixated ('scleral-glued') IOL insertion in the setting of PXF and poor or absent capsular support. RESULTS: 28 eyes were included in the study. The indications for scleral-glued IOL fixation included late endocapsular IOL dislocation (21/28, 75%), exchange for iris-fixated IOL due to complication (4/28, 14%), subluxed crystalline lens (2/28, 7%), and aphakia after complicated cataract surgery (1/28, 4%)...
December 1, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29189945/could-adverse-effects-and-complications-of-selective-laser-trabeculoplasty-be-decreased-by-low-power-laser-therapy
#3
REVIEW
Alexandre de Carvalho Mendes Paiva, Adenilson de Souza da Fonseca
Selective laser trabeculoplasty (SLT) has been used for treatment of primary open-angle glaucoma, ocular hypertension, pigmenter and pseudoexfoliative glaucoma being considered a low-risk procedure. Therefore, transitory and permanent adverse effects have been reported, including corneal changes, subclinical edema, and reduction in endothelial cells and in central corneal thickness. Despite rarer, serious corneal complications after SLT can be permanent and lead to visual impairment, central corneal haze, opacity and narrowing...
November 30, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29182401/the-association-of-cataract-and-lens-epithelial-cell-apoptosis-in-patients-with-pseudoexfoliation-syndrome
#4
Pembe Oltulu, Refik Oltulu
PURPOSE: The aim of this study was to measure the density of apoptotic lens epithelial cells (LECs) and to determine its association with cataract formation in eyes with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Twenty-one eyes of 21 patients diagnosed with PEX without glaucoma (Group 1) and 22 eyes of 22 subjects without PEX (Group 2) were enrolled in this study. During cataract surgery, anterior capsule samples were obtained by the 5.5 mm continuous curvilinear capsulorhexis method...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29173472/levels-of-aqueous-humor-trace-elements-in-patients-with-open-angle-glaucoma
#5
Bettina Hohberger, M Anwar Chaudhri, Bernhard Michalke, Marianna Lucio, Katarzyna Nowomiejska, Ursula Schlötzer-Schrehardt, Pawel Grieb, Robert Rejdak, Anselm G M Jünemann
PURPOSE: Trace elements might play a role in the complex multifactorial pathogenesis of open-angle glaucoma. The aim of this study was to analyze concentrations of trace elements in aqueous humor samples of patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG). PATIENTS AND METHODS: Thirty-three aqueous humor samples were obtained from patients undergoing cataract surgery: 12 patients with POAG (age 65.3±10.50, female 8, male 4), 10 patients with PEXG (age 65...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29164236/posttranscriptional-regulation-of-loxl1-expression-via-alternative-splicing-and-nonsense-mediated-mrna-decay-as-an-adaptive-stress-response
#6
Daniel Berner, Matthias Zenkel, Francesca Pasutto, Ursula Hoja, Panah Liravi, Gabriele C Gusek-Schneider, Friedrich E Kruse, Johannes Schödel, Andre Reis, Ursula Schlötzer-Schrehardt
Purpose: Alternative mRNA splicing coupled to nonsense-mediated decay (NMD) is a common mRNA surveillance pathway also known to dynamically modulate gene expression in response to cellular stress. Here, we investigated the involvement of this pathway in the regulation of lysyl oxidase-like 1 (LOXL1) expression in response to pseudoexfoliation (PEX)-associated pathophysiologic factors. Methods: Transcript levels of LOXL1 isoforms were determined in ocular tissues obtained from donor eyes without and with PEX syndrome...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29118499/causes-and-management-of-small-pupil-in-patients-with-cataract
#7
Ioannis Halkiadakis, Irini Chatziralli, Evangelos Drakos, Michail Katzakis, Sotirios Skouriotis, Eleni Patsea, Panagiotis Mitropoulos, Artemios Kandarakis
BACKGROUND: The purpose of the study was to present the causes and management of small pupil (<6 mm) in Greek patients with cataract. METHODS: About 1144 consecutive patients with cataract comprised the study group. The pupil size was measured after maximal dilation by means of Rosenbaum cards and Colvard pupillometer. Dilation regimen included phenylephrine 10%, tropicamide 1%, cyclopentolate 1%, and ketorolac trometamol 0.5% administered 3 times at 5 min intervals starting 1 h before surgery...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29104957/scleral-fixated-intraocular-lenses-past-and-present
#8
Maxwell S Stem, Bozho Todorich, Maria A Woodward, Jason Hsu, Jeremy D Wolfe
Intraocular lenses (IOLs) can have inadequate support for placement in the capsular bag as a result of ocular trauma, metabolic or inherited conditions such as Marfan's syndrome or pseudoexfoliation, or complicated cataract surgery. Surgical options for patients with inadequate capsular support include alternative placement in the anterior chamber (ACIOLs), fixation to the iris, or fixation to the sclera. The surgical techniques for each of these approaches have improved considerably over the last several decades resulting in improved visual and ocular outcomes...
March 2017: Journal of Vitreoretinal Diseases
https://www.readbyqxmd.com/read/29081937/measurements-of-corneal-thickness-in-eyes-with-pseudoexfoliation-syndrome-comparative-study-of-different-image-processing-protocols
#9
Katarzyna Krysik, Dariusz Dobrowolski, Katarzyna Polanowska, Anita Lyssek-Boron, Edward A Wylegala
PURPOSE: Comparative analysis of central and peripheral corneal thickness in PEX patients using three different imaging systems: Pentacam-Scheimpflug device, time-domain optical coherence tomography (OCT) Visante, and swept-source OCT Casia. MATERIALS AND METHODS: 128 eyes of 80 patients with diagnosed PEX were examined and compared with 112 normal, non-PEX eyes of 72 cataract patients. The study parameters included 5 measured zones: central and 4 peripheral (superior, inferior, nasal, and temporal)...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29078224/-spontaneous-iol-dislocation-what-can-we-do-for-prevention
#10
Joern Kuchenbecker
IOL dislocation and opacification represent further complications of modern IOL (intraocular lenses) implantation. Currently, an increase of IOL dislocation due to various reasons is observed. Due to capsular bag shrinkage, especially in patients with pseudoexfoliation (PEX) and other ocular condition, there is an increasing tension of the weakened zonula. The only use of capsular tension ring (CRT) is not sufficient. The shrinkage of the capsular bag and increasing tension of the zonula may be reduced by additional anterior capsule incisions...
October 27, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29077713/clinical-spectrum-of-pseudoexfoliation-syndrome-an-electronic-records-audit
#11
Aparna Rao, Debananda Padhy, Prity Sahay, Amiya Pradhan, Sarada Sarangi, Gopinath Das, Niranjan Raj
PURPOSE: To evaluate different clinical variants of pseudoexfoliation syndrome and their risk of developing ocular hypertension (OHT) or glaucoma (PXG). DESIGN: Cross sectional hospital based study. SETTING: All patients seen at glaucoma services of a tertiary eye care center in east India. METHODS: Electronic medical records search of hospital database including consecutive new and old cases seen during April 2013 to March 2015 was done to retrieve case sensitive words including pseudoexfoliation, PXF, PEX, PXG and pseudoexfoliative glaucoma over any part of the clinical electronic sheet of the patient...
2017: PloS One
https://www.readbyqxmd.com/read/29077625/chronic-and-intermittent-angle-closure-caused-by-in-the-bag-capsular-tension-ring-and-intraocular-lens-dislocation-in-patients-with-pseudoexfoliation-syndrome
#12
Frank Bochmann, Jörg Strümer
PURPOSE: A subluxation or dislocation of the intraocular lens (IOL) is a well-known complication after cataract surgery in patients with pseudoexfoliation syndrome (PEX). Capsular tension rings (CTR) are frequently used to prevent postoperative complications caused by zonular weakness. Here we present a series of 7 cases, 2 with intermittent and 5 with acute angle closure caused by a combination of PEX-associated zonular weakness and a resulting unstable capsular bag-CTR-IOL complex. MATERIALS AND METHODS: We describe the typical clinical course with elevated intraocular pressure, myopic shift, and shallowing of the anterior chamber in 7 patients with a new type of secondary angle closure...
November 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29077522/a-novel-uveolymphatic-drainage-pathway-possible-new-target-for-glaucoma-treatment
#13
Martyna Tomczyk-Socha, Anna Turno-Kręcicka
Glaucoma is a heterogeneous group of ophthalmic diseases leading to irreversible damage to the optic nerve. While the overall mechanism responsible for glaucoma remains obscure, the most important risk factor is elevated intraocular pressure. The current therapies, whether pharmacological or surgical, are primarily symptomatic with the aim to lower the intraocular pressure (IOP). Poorer response to treatment is associated, for example, with pseudoexfoliation glaucoma, which is determined by blocking the trabecular meshwork (TM) both by pigment grains and the pseudoexfoliation material...
October 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29068575/evaluation-of-the-anterior-chamber-angle-in-pseudoexfoliation-syndrome
#14
Małgorzata Iwanejko, Anna Turno-Kręcicka, Martyna Tomczyk-Socha, Kamil Kaczorowski, Andrzej Grzybowski, Marta Misiuk-Hojło
BACKGROUND: Pseudoexfoliation syndrome (PEX) is the most frequently identifiable cause of secondary open-angle glaucoma, known as pseudoexfoliation glaucoma. The exact pathophysiology and etiology of PEX and associated glaucoma remains obscure. OBJECTIVES: The purpose of this study was to determine the differences in the morphology of the anterior chamber angle in people with pseudoexfoliation syndrome and pseudoexfoliation glaucoma compared to a control group. We also evaluated the correlation between intraocular pressure (IOP) and pigmentation of the angle with the amount of exfoliated material in the anterior segment...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29044059/pathology-and-immunohistochemistry-of-capsular-bag-in-spontaneously-late-dislocated-capsular-bag-intraocular-lens-complex
#15
Harsha Bhattacharjee, Kasturi Bhattacharjee, Dipankar Das, Manpreet Singh, Piruthivi Sukumar, Diva Kant Misra
PURPOSE: Our study aims to evaluate the morphology, histopathology, and immunohistochemistry of the spontaneously late dislocated capsular bag-intraocular lens (CB-IOL) complex. Various etiologies and possible pathogenesis of the event are also discussed. METHODS: This was a tertiary-care setting and retrospective observational case series. The surgically explanted intact specimens of spontaneously late dislocated CB-IOL complex were studied. The demographics, duration of pseudophakia, IOL design/material, and specimen measurements were noted...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29038959/the-effect-of-additional-trabecular-aspiration-to-phacoemulsification-and-trabectome-as-a-triple-procedure-in-pseudoexfoliation-glaucoma-a-case-matched-study
#16
R A Widder, J F Jordan, P Kühnrich, J Luebke, G F Roessler, A Anton
BACKGROUND: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees of the meshwork can be reached. This study was conducted to investigate the additional benefits and risks of adding trabecular aspiration to the combination of phacoemulsification and trabectome as a triple procedure...
October 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29030797/corneal-endothelial-changes-following-a-single-session-of-selective-laser-trabeculoplasty-for-pseudoexfoliative-glaucoma
#17
Nurgül Örnek, Kemal Örnek
PURPOSE: To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients. METHODS: Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees of inferior trabecular meshwork. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical, Hyogo, Japan)...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026286/intraoperative-optical-coherence-tomography-and-ab-interno-trabecular-meshwork-surgery-with-the-trabectome
#18
Bernd Junker, Jens F Jordan, Carsten Framme, Amelie Pielen
IMPORTANCE: This study is the first description of the use of the intraoperative optical coherence tomography (iOCT) for trabecular meshwork surgery with the Trabectome in a regular clinical setting. BACKGROUND: The aim of this study is to evaluate intraoperatively the immediate success of ab interno trabeculotomy with the Trabectome defined as a removal of the trabecular meshwork. DESIGN: This is a retrospective clinical study performed in the University Eye Hospital, Medical School Hannover...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28991617/goniotomy-with-a-single-use-dual-blade-short-term-results
#19
Michael D Greenwood, Leonard K Seibold, Nathan M Radcliffe, Syril K Dorairaj, Ahmad A Aref, Jesús Jimenez Román, Gabriel S Lazcano-Gomez, Jason K Darlington, Suhail Abdullah, Mark C Jasek, Khaled A Bahjri, John P Berdahl
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a single-use dual blade (Kahook) in patients with mild to end-stage glaucoma. SETTING: International multicenter ophthalmic care centers. DESIGN: Prospective interventional case series. METHODS: Consecutive patients with glaucoma who had phacoemulsification plus goniotomy with the single-use dual blade were enrolled in this study. Each center collected deidentified clinical data, including preoperative and postoperative IOP, medication use, adverse events, and whether additional surgery was required during a 6-month follow-up...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28984715/suprachoroidal-bleeding-after-xen-gel-implantation
#20
Verena Prokosch-Willing, Urs Vossmerbaeumer, Esther Hoffmann, Norbert Pfeiffer
PURPOSE: To report for the first time a clinical case of suprachoroidal bleeding after XEN45®gel implantation. OBSERVATIONS: A 84-year old female patient with pseudoexfoliation glaucoma with intraocular pressure (20 mm Hg) above target despite maximal IOP lowering therapy was scheduled for XEN45® gel implantation. The XEN45® gel implantation went without complications and was properly placed in the anterior chamber and beneath the conjunctiva. On the first postoperative day, the patient presented with an IOP of 4 mm Hg, a functioning bleb and a deep anterior chamber...
September 3, 2017: Journal of Glaucoma
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