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pseudoexfoliation

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https://www.readbyqxmd.com/read/28814824/cataract-surgery-in-patients-with-pseudoex-foliation-syndrome-current-updates
#1
REVIEW
Luigi Fontana, Marco Coassin, Alfonso Iovieno, Antonio Moramarco, Luca Cimino
Pseudoexfoliation is a ubiquitous syndrome of multifactorial origin affecting elderly people by increasing the risk of cataract and secondary glaucoma development. Despite modern techniques and technologies for cataract surgery, pseudoexfoliation syndrome represents a challenge for surgeons because of the increased weakness of the zonular apparatus and limited pupil dilation. Due to the inherent difficulties during surgery, the risk of vitreous loss in these patients is several times higher than in cataract patients without pseudoexfoliation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28797085/comparison-of-cytokine-profiles-in-the-aqueous-humor-of-eyes-with-pseudoexfoliation-syndrome-and-glaucoma
#2
Justus G Garweg, Souska Zandi, Isabel B Pfister, Magdalena Skowronska, Christin Gerhardt
PURPOSE: To compare the cyto- and chemokine profiles in the aqueous humor of PEXS eyes in the absence or presence of secondary glaucoma with or without luxation of the intraocular lens (IOL). METHODS: Samples of aqueous humor were collected intraoperatively from 20 healthy controls and from 73 eyes with PEX-syndrome, which was manifested in the absence of any other local or systemic desease. The latter group was sub-devided into eyes with an early form of PEX-syndrome in the absence of complications (PEX, n = 33), those with a late form of PEX-syndrome and glaucoma (PEXG, n = 30), and those with a late form of PEX-syndrome with luxation of the IOL that required surgery (PEXL, n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/28791066/corneal-alterations-associated-with-pseudoexfoliation-syndrome-and-glaucoma-a-literature-review
#3
REVIEW
Joel R Palko, Owen Qi, Arsham Sheybani
A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28777224/short-term-results-of-trabeculectomy-using-adjunctive-intracameral-bevacizumab-versus-mitomycin-c-a-randomized-controlled-trial
#4
Zakieh Vahedian, Mostafa Mafi, Ghasem Fakhraie, Reza Zarei, Yadollah Eslami, Hadi Ghadimi, Masomeh Mohebbi
PURPOSE: To compare the outcome of trabeculectomy using adjunctive intracameral bevacizumab versus intraoperative mitomycin C (MMC) MATERIALS AND METHODS:: In this double-blind, randomized clinical trial 87 eyes of 87 patients with primary open-angle or pseudoexfoliation glaucoma were assigned to each treatment group (44 cases received 1.25 mg intracameral bevacizumab at the end of operation and in 43 cases MMC was applied during surgery). Success was defined as intraocular pressure (IOP) between 6 and 21 mm Hg and at least 30% IOP drop with (qualified) or without (complete) glaucoma medications without additional glaucoma surgery...
August 2, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28774519/undetected-angle-closure-in-patients-with-a-diagnosis-of-open-angle-glaucoma
#5
Devesh K Varma, Sarah M Simpson, Amandeep S Rai, Iqbal Ike K Ahmed
OBJECTIVE: The aim of this study was to identify the proportion of patients referred to a tertiary glaucoma centre with a diagnosis of open-angle glaucoma (OAG) who were found to have angle closure glaucoma. DESIGN: Retrospective chart review. METHODS: Consecutive new patients referred for glaucoma management to a tertiary centre between July 2010 and December 2011 were reviewed. Patients whose referrals for glaucoma assessment specified angle status as "open" were included...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28745651/-studying-the-association-between-genetic-polymorphism-of-growth-factors-and-the-development-of-primary-open-angle-glaucoma
#6
M Yu Kirilenko, E V Tikunova, S S Sirotina, A V Polonikov, O Yu Bushueva, M I Churnosov
Primary open-angle glaucoma (POAG) is a multifactorial disease, etiopathogenesis of which largely depends on growth factors. Possessing a variety of medical and biological effects, these cytokines may influence the development and progression of POAG. AIM: to reveal the role of genetic polymorphisms of growth factors in predisposition to developing POAG that is refractory to local hypotensive therapy. MATERIAL AND METHODS: The object of the study were 162 patients with stage II-III POAG, in whom local hypotensive therapy was inefficient, 90 patients with stage II-III POAG well controlled on local hypotensive therapy, and 191 controls...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28743412/pseudoexfoliation-signs-in-the-anterior-segment-assessed-by-optical-coherence-tomography-and-scheimpflug-device
#7
J I Fernández-Vigo, L de-Pablo Gómez de Liaño, I Sánchez-Guillen, A Macarro-Merino, C Fernández-Vigo, J García-Feijóo, J A Fernández-Vigo
OBJECTIVE: To evaluate different anterior segment parameters in eyes with pseudoexfoliation (PSX), fellow eyes, and controls using optical coherence tomography and a Scheimpflug imaging system. METHODS: Three groups were studied: 44 eyes of 44 patients with PSX, 30 clinically unaffected fellow eyes, and 148 eyes of 148 healthy controls. The anterior chamber depth and volume, corneal volume and thickness, pupil diameter and corneal densitometry were measured using a Scheimpflug imaging system (Pentacam, Oculus Inc...
July 22, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28671924/long-term-outcome-of-surgical-treatment-for-late-intraocular-lens-dislocation-associated-with-high-intraocular-pressure-a-case-series
#8
Lucas A Torres, Jayme R Vianna, Marcelo T Nicolela
PURPOSE: To demonstrate the long-term safety and efficacy of transscleral intraocular lens (IOL) fixation combined with an Ahmed glaucoma drainage device implantation for patients with late IOL dislocation and high intraocular pressure (IOP). METHODS: This is a retrospective report of a series of patients who underwent this combined surgery. The main outcome variables studied were change in visual acuity (VA), IOP, and number of medications compared with preoperative levels...
June 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28660443/isoforms-of-tgf-%C3%AE-in-the-aqueous-humor-of-patients-with-pseudoexfoliation-syndrome-and-a-possible-association-with-the-long-term-stability-of-the-capsular-bag-after-cataract-surgery
#9
Justus G Garweg, Souska Zandi, Christin Gerhardt, Isabel B Pfister
BACKGROUND: Pseudoexfoliation syndrome (PEXS) may go along with capsular bag shrinkage and luxation. In the present study, we focus on an association of isoforms of TGF-β with capsular bag luxation. METHODS: Aqueous humor was collected intraoperatively from 20 healthy controls and from 73 otherwise healthy patients with PEXS [PEXS without complications (PEX, n = 33), late PEXS with glaucoma (PEXG, n = 30) and with IOL and capsular bag luxation (PEXL, n = 10)]...
June 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28652699/ophthalmological-findings-in-cameroonian-boxers
#10
Giles Kagmeni, Georges Nguefack-Tsague, Steve Robert Ebana Mvogo, Come Ebana Mvogo
BACKGROUND: The purpose of this prospective, noncomparative consecutive study was to examine active and retired amateur boxers in order to evaluate the nature and incidence of ocular pathologic conditions related to the boxing practice. RESULTS: A total of 35 boxers were included in this study. The mean age of the boxers was 28.09±7.57 years (range 18-52 years). Sixteen (45.7%) boxers had >5 years of boxing experience. Fifteen (42.85%) of the boxers reported wearing protective equipment in the bouts and sparring rounds...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28644852/comparisons-of-retinal-vessel-diameter-and-glaucomatous-parameters-between-both-eyes-of-subjects-with-clinically-unilateral-pseudoexfoliation-syndrome
#11
Yasuyuki Takai, Masaki Tanito, Tetsuro Omura, Ryo Kawasaki, Yumiko Kawasaki, Akihiro Ohira
PURPOSE: Pseudoexfoliation syndrome (PEX), the most common identifiable cause of open-angle glaucoma, might affect the retinal hemodynamics. To test this, we compared retinal vessel diameter and glaucoma-related parameters between eyes with pseudoexfoliation material (PE+) and fellow unaffected (PE-) eyes of patients with clinically unilateral PEX. METHODS: The medical records of 30 consecutive Japanese subjects were reviewed retrospectively. The retinal vessel diameters were measured and expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) using standardized software...
2017: PloS One
https://www.readbyqxmd.com/read/28624324/risk-factors-for-rapid-glaucoma-disease-progression
#12
MULTICENTER STUDY
Thomas Chun Wai Chan, Chandra Bala, Anna Siu, Fiona Wan, Andrew White
PURPOSE: To determine the intraocular and systemic risk factor differences between a cohort of rapid glaucoma disease progressors and nonrapid disease progressors. DESIGN: Retrospective case-control study. METHODS: Setting: Five private ophthalmology clinics. STUDY POPULATION: Forty-eight rapidly progressing eyes (progression ≥1 dB mean deviation [MD]/year) and 486 non-rapidly progressing eyes (progression <1 dB MD/year)...
August 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28622050/serum-and-aqueous-humor-levels-of-fetuin-a-in-pseudoexfoliation-syndrome
#13
Nilay Yuksel, Tamer Takmaz, Ummuhani Ozel Turkcu, Merve Ergin, Hasan Altinkaynak, Ayse Bilgihan
PURPOSE: To evaluate serum and aqueous humor levels of fetuin-A in patients with pseudoexfoliation syndrome (PEXS) in comparison with those of age- and sex-matched healthy subjects. MATERIALS AND METHODS: This prospective study included 25 patients with PEXS and 25 control subjects who were undergoing cataract surgery without any systemic or ocular disease. Aqueous humor and serum fetuin-A levels were measured with enzyme-linked immunosorbent assay method. RESULTS: The mean age of the PEXS group (14 males, 11 females, n = 25) was 57...
June 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28617722/prevalence-of-pseudoexfoliation-syndrome-in-an-isolated-island-population-of-korea-the-woodo-study
#14
Sang-Yoon Lee, Seondo Kim, Jeong Hong Kim, Sung-Chul Hong, Keun Hwa Lee, Hye-Sook Lee, Aesun Shin, Jinho Jeong
PURPOSE: To determine the prevalence and clinical characteristics of pseudoexfoliation syndrome (PXS) within Korean population living in Woodo Island. METHODS: Among the 625 residents aged 50 years or older, 305 residents (197 women and 108 men) participated in the study; a response rate of 48.8%. Participants filled out questionnaires on life style. Intraocular pressure and corneal endothelial cell function was measured. Both pupils were dilated. Fundus photographs and stereo disc photographs were taken...
June 14, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28614223/trabectome-success-factors
#15
Constance O Okeke, Eydie Miller-Ellis, Mario Rojas
Our objective is to investigate which factors and patient characteristics are associated with success in Trabectome surgery.A total of 658 phakic cases with at least of 12 months follow-up were included in the analysis. Baseline demographics and medical data were collected. The main outcome measure was intraocular pressure (IOP), glaucoma medication (Rx), and secondary glaucoma surgery if any. Success was defined as IOP reduction of 20% or more from preoperative IOP and IOP < 21 mm Hg with no secondary surgery throughout the follow-up period...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28604573/pupillometry-as-a-screening-tool-to-detect-pseudoexfoliation-syndrome
#16
Erdogan Yasar, Nilgun Yildirim, Eray Atalay, Emre Tambova, Ertugrul Colak
PURPOSE: Our objective was to evaluate the diagnostic value of a handheld pupillometer in differentiating eyes with pseudoexfoliation syndrome (PXS) from healthy controls. METHODS: This population-based, cross-sectional study was conducted in the province of Eskisehir, Turkey. Subjects 40 years of age and older were randomly recruited using stratified two-stage cluster sampling from the database of the Turkish Statistical Institute office in Eskisehir. Recruitment took place between June and October 2014...
June 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28602322/trabecular-microbypass-stent-implantation-with-cataract-extraction-in%C3%A2-pseudoexfoliation-glaucoma
#17
Tanner J Ferguson, Russell Swan, Mitch Ibach, Justin Schweitzer, Ramu Sudhagoni, John P Berdahl
PURPOSE: To evaluate the safety and efficacy of a trabecular microbypass stent (iStent) combined with cataract surgery in patients with pseudoexfoliation glaucoma (PXG). SETTING: Vance Thompson Vision, Sioux Falls, South Dakota, USA. DESIGN: Retrospective case series. METHODS: Eyes with PXG had implantation of 1 stent. Data were collected preoperatively and postoperatively through 24 months. Data included intraocular pressure (IOP), number of glaucoma medications, the incidence of postoperative IOP pressure spikes of 15 mm Hg or higher at any timepoint, and the need for additional surgery...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28600745/safety-and-effectiveness-of-gold-glaucoma-micro-shunt-for-reducing-intraocular-pressure-in-japanese-patients-with-open-angle-glaucoma
#18
Masaki Tanito, Etsuo Chihara
PURPOSE: To assess the safety and effectiveness of the SOLX gold shunt (GS) in reducing intraocular pressure (IOP) in Japanese patients with open angle glaucoma (OAG). METHODS: 24 eyes of 24 subjects [mean age of 68.9 ± 12.7 years; 13 (54%) women; 16 (67%) POAG, 7 (29%) pseudoexfoliation glaucoma, and 1 (4%) steroid response glaucoma] were implanted with the GS either with or without cataract surgery. Best-corrected visual acuity (BCVA), IOP, corneal endothelial cell density (CECD), anterior chamber (AC) flare, surgical complications, and required interventions were monitored at baseline, and 1 day, 1 week, 1, 3 and 6 months, and 1 year postoperatively...
June 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28586796/functional-activity-of-matrix-metalloproteinases-2-and-9-in-tears-of-patients-with-glaucoma
#19
Prity Sahay, Aparna Rao, Debananda Padhy, Sarada Sarangi, Gopinath Das, Mamatha M Reddy, Rahul Modak
Purpose: To evaluate the differential expression of tear matrix metalloproteinases (MMP) 2 and 9 in of patients with various forms of glaucoma. Methods: Tear samples were collected with a Schirmer's strip from 148 eyes of 113 patients (medically naïve patients with primary open-angle [POAG] or angle closure glaucoma [PACG] and those with pseudoexfoliation syndrome [PXF] or glaucoma [PXG]). These were compared to patients undergoing cataract surgery (controls) for this cross-sectional study...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28571835/-cataract-surgery-among-50-alzheimer-s-patient-55-eyes
#20
B Girard, B Chouard, F Hardy
OBJECTIVE: Cataract surgery for 50 Alzheimer patients (55 eyes). METHODS: Cinquante Alzheimer's patients with 0≤MMS≤25, with bilateral disabling cataracts were included for surgery. The surgical technique is analyzed. RESULTS AND CONCLUSION: The preoperative examination of Alzheimer's patients is time consuming and requires experience in this area, which is important to integrate into the practice of ophthalmology. The type of cataract is unusual, with a predilection for pseudoexfoliation syndrome and zonular fragility that has to be managed during surgery...
May 29, 2017: Journal Français D'ophtalmologie
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