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pseudoexfoliation

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https://www.readbyqxmd.com/read/28534485/pseudoexfoliation-syndrome-associated-genetic-variants-affect-transcription-factor-binding-and-alternative-splicing-of-loxl1
#1
Francesca Pasutto, Matthias Zenkel, Ursula Hoja, Daniel Berner, Steffen Uebe, Fulvia Ferrazzi, Johannes Schödel, Panah Liravi, Mineo Ozaki, Daniela Paoli, Paolo Frezzotti, Takanori Mizoguchi, Satoko Nakano, Toshiaki Kubota, Shinichi Manabe, Erika Salvi, Paolo Manunta, Daniele Cusi, Christian Gieger, Heinz-Erich Wichmann, Tin Aung, Chiea Chuen Khor, Friedrich E Kruse, André Reis, Ursula Schlötzer-Schrehardt
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular complications, no functional variants have been identified to date. Here, we conduct a genome-wide association scan on 771 German PEX patients and 1,350 controls, followed by independent testing of associated variants in Italian and Japanese data sets. We focus on a 3.5-kb four-component polymorphic locus positioned spanning introns 1 and 2 of LOXL1 with enhancer-like chromatin features...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534232/spontaneous-dislocation-of-the-posterior-chamber-intraocular-lens
#2
Azusa Fujikawa, Yasser Helmy Mohamed, Hirofumi Kinoshita, Eiko Tsuiki, Takashi Kitaoka
AIM: To evaluate the possible risk factors for posterior chamber intraocular lens dislocation either in-the-bag (ITB) dislocation or out-of-the-bag (OOTB) dislocation. METHODS: All subjects who sustained late intraocular lens dislocation from January 2011 until May 2014 and presented to the Nagasaki University Hospital were included in the study. This study is a retrospective evaluation of all cases of posterior chamber intraocular lens dislocation in this defined period...
May 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28503365/genetics-diagnosis-and-monitoring-of-pseudoexfoliation-glaucoma
#3
Niraj Nathan, Rachel W Kuchtey
Recent studies have shed new light on the genetic factors underlying pseudoexfoliation syndrome, growing our understanding of the role of the lysyl oxidase-like 1 (LOXL1) gene and its various polymorphisms as well as identifying new genetic associations. Recent years have brought new insight on how these genetic factors interact with other factors, including environmental, to confer risk to individuals and populations worldwide. All of these findings may hold importance to the screening, diagnosis, and monitoring of pseudoexfoliation and may also help lead to the identification of novel therapeutic targets...
December 2016: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28465815/levels-of-cytokines-in-the-aqueous-humor-of-eyes-with-primary-open-angle-glaucoma-pseudoexfoliation-glaucoma-and-cataract
#4
Nervana Khalef, Hany Labib, Hazem Helmy, Mona Abd El Hamid, Leqaa Moemen, Iman Fahmy
OBJECTIVE: The focus of this study aimed at measuring multiple inflammatory cytokines levels in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PEXG) and senile cataract. METHODS: This case control study was conducted at the Research Institute of Ophthalmology, Giza, Egypt in 2016. Aqueous humor (AH) samples were withdrawn from 50 patients (30 POAG, and 20 PEXG) and from 15 patients with senile cataract serving as controls...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28458512/no-differences-in-central-corneal-thickness-between-open-angle-and-pseudoexfoliation-glaucoma-patients
#5
Marcelo Ayala, Johanna Karlsson
INTRODUCTION: Measurements of intraocular pressure (IOP) with Goldmann applanation tonometry are affected by central corneal thickness (CCT), as thinner corneas underestimate and thicker corneas overestimate the true IOP value. The literature is controversial regarding CCT values in patients with primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG). The aim of this study was to evaluate CCT in patients with XFG and POAG. METHODS: CCT was evaluated with optical coherence tomography (OCT)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28457115/pseudoexfoliation-an-ocular-finding-with-possible-systemic-implications
#6
REVIEW
Uri Aviv, Daniel Ben Ner, Nardeen Sharif, Zvi Gur, Asaf Achiron
Pseudoexfoliation syndrome (PES) is a common age-related disorder affecting 60-70 million people worldwide. Patients with PES have abnormal production and deposition of fibrillar material in the anterior chamber of the eye. These exfoliated fibrils, easily detected by ocular slit-lamp examination, have also been found to exist systematically in the skin, heart, lungs, liver and kidneys. Recently, myriad studies have associated PES with systemic conditions such as increased vascular risk, risk of dementia and inflammatory state...
January 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28450942/immunohistochemical-analysis-of-microsomal-glutathione-s-transferase-1-and-clusterin-expression-in-lens-epithelial-cells-of-patients-with-pseudoexfoliation-syndrome
#7
Joanna Stafiej, Marta Hałas-Wiśniewska, Magdalena Izdebska, Maciej Gagat, Dariusz Grzanka, Alina Grzanka, Grażyna Malukiewicz
Pseudoexfoliation syndrome (PEX) is an age-associated, sight disorder affecting elastic fibers in the eye and visceral organs but its exact etiology remains unknown. The purpose of the current study was to determine the morphology and ultrastructure of lens epithelial cells (LECs), and to use immunohistochemistry to examine localization of microsomal glutathione S-transferase 1 (MGST1) and clusterin. Anterior lens capsules were obtained from 24 patients (13 PEX and 11 controls) who underwent phacoemulsification...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28416927/cataract-surgery-and-possible-complications-in-patients-with-pseudoexfoliation-syndrome
#8
Gulsum Egemen Erkayhan, Semih Dogan
OBJECTIVE: The aim of this study was to evaluate the demographic characteristics and intraoperative complications of cataract surgery in patients with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Cases of 225 eyes (80 eyes with pseudoexfoliation and 145 eyes without pseudoexfoliation as the control group) that underwent phacoemulsification cataract surgery and IOL implantation at the Silifke State Hospital Ophthalmology Clinic between April 2011 and April 2013 were analysed retrospectively...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28405788/electroneuromyographic-findings-in-pseudoexfoliation-syndrome
#9
Deniz Turgut Coban, Tuncay Cakir, Muhammet Kazim Erol, Gulsum Dogan, Berna Dogan, Meral Bilgilisoy Filiz, Naciye Fusun Toraman
PURPOSE: To examine peripheral electroneuromyographic findings in patients with ocular pseudoexfoliation syndrome (PEX) and to compare them controls without PEX. METHODS: A case-control study design was used to examine 31 patients with PEX and compare the findings with those of 31 age- and sex-matched healthy controls. All patients underwent complete ophthalmologic examination that included peripheral electroneuromyography examination. Motor and sensorial nerve conduction of the median, ulnar, tibial, peroneal, and sural nerve and the sympathetic skin response were measured...
April 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28405485/spontaneous-late-intraocular-lens-and-capsule-tension-ring-dislocation
#10
Ayşe Gül Koçak Altıntaş, Aslıhan Esra Omay, Selda Çelik
In this report, three cases with pseudoexfoliation (PEX) and advanced age with spontaneous intraocular lens (IOL) and capsule tension ring (CTR) dislocation were presented. All of our cases experienced progressive vision loss without an episode of strenuous physical activity, trauma, or any other ocular disease. Spontaneous dislocation was observed 2.5 to 8 years after uneventful phacosurgery. Each patient underwent complete IOL and CTR removal combined with anterior chamber IOL implantation. No complications were noticed during follow-up...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28376552/three-cases-of-spontaneous-hyphaema
#11
P Bauer, P B Henrich, J Stürmer
Background Spontaneous anterior chamber bleeding is a rare event. We present three photodocumented cases treated in our clinic. History and Findings Three patients sought medical assistance in our clinic because of bleeding inside the eye and/or visual impairment. None of them had a history of trauma or intraocular surgery. Treatment and Outcome Two patients had oral anticoagulation, which was discontinued. These cases were treated with topical steroids. The third patient had no anticoagulation and no topical steroids were used in treatment...
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28369002/association-of-lysyl-oxidase-like-1-gene-polymorphism-in-turkish-patients-with-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#12
Mahmut Asfuroglu, Busranur Cavdarli, Özlem Gurbuz Koz, Ahmet A Yarangumeli, Emine Y Ozdemir
No abstract text is available yet for this article.
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28369001/association-of-lysyl-oxidase-like-1-gene-polymorphism-in-turkish-patients-with-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#13
Suzan Guven Yilmaz, Melis Palamar, Hüseyin Onay, Orhan Ilim, Ayca Aykut, Feristah F Ozkinay, Ayse Yagci
No abstract text is available yet for this article.
March 31, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28345572/late-dislocation-of-in-the-bag-intraocular-lenses-in-uveitic-eyes-an-analysis-of-management-and-complications
#14
Sudha K Ganesh, Parveen Sen, Hitesh R Sharma
AIM: An analysis of late in-the-bag dislocation of intraocular lenses (IOL), in uveitic eyes. SETTING: Referral uveitis clinic. DESIGN: Retrospective case series. MATERIALS AND METHODS: All case records of eyes with chronic uveitis that had phacoemulsification with IOL implantation, at a referral uveitis clinic between February 1997 and January 2015 were retrieved and analyzed. Only those eyes with no documented intraoperative complication and no predisposing risks to IOL dislocation, such as pseudoexfoliation, high myopia, trauma, and prior VR surgery were included in this study...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28300736/the-melaka-hospital-cataract-complications-study-analysis-of-12-992-eyes
#15
Thanigasalam Thevi, Zin Maizura, Adinegara Lutfi Abas
INTRODUCTION: As in all surgeries, complications during cataract surgery are unavoidable and cause distress to the surgeon and the patient. This study was conducted to know the factors contributing to complications in our settings, to be able to counsel patients about complications and outcomes and to reduce litigations. MATERIALS AND METHODS: The secondary data analysis was conducted using the National Eye Database from 2007 to 2014. Demographic features, ocular comorbidities, technique of surgery, grade of surgeons, types of intraoperative complications, and reasons for not obtaining good visual acuity following intraoperative complications were studied...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28299500/mthfr-and-mthfd1-gene-polymorphisms-are-not-associated-with-pseudoexfoliation-syndrome-in-south-indian-population
#16
Prakadeeswari Gopalakrishnan, Aravind Haripriya, Periasamy Sundaresan
PURPOSE: Pseudoexfoliation syndrome (PEX) is a late onset disorder of extracellular matrix turnover, associated systemically with cardiovascular and cerebrovascular disease. To evaluate the suggested association of polymorphisms of homocysteine metabolism genes MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) with PEX. METHODS: A case-control association study was undertaken, comprising a total of 1472 individuals including 860 unrelated PEX cases and 612 ethnic-matched cataract controls (CC)...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28292773/the-malaysian-cataract-surgery-registry-risk-indicators-for-posterior-capsular-rupture
#17
Mohamad Aziz Salowi, Fiona L M Chew, Tassha Hilda Adnan, Mariam Ismail, Pik-Pin Goh
AIM: To identify the risk indicators for posterior capsular rupture (PCR) in the Malaysian Cataract Surgery Registry (CSR). METHODS: Data from the web-based CSR were collected for cataract surgery performed from 2008 to 2013. Data was contributed by 36 Malaysian Ministry of Health public hospitals. Information on patient's age, ethnicity, cause of cataract, ocular and systemic comorbidity, type of cataract surgery performed, local anaesthesia and surgeon's status was noted...
March 14, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28278318/association-of-pseudoexfoliation-with-systemic-vascular-diseases-in-a-south-indian-population
#18
COMPARATIVE STUDY
Ashok Vardhan S, Aravind Haripriya, Banushree Ratukondla, Pradeep Ramulu, Chandrasekaran Shivakumar, Manas Nath, Prabhu Vijayaraghavan, Alan L Robin
Importance: Ocular pseudoexfoliation (PEX) syndrome may be associated with systemic vascular diseases, which might suggest a broader health significance of PEX, although previous reports are conflicting. Objective: To determine whether prespecified vascular risk factors and cardiac abnormalities are more common among patients with PEX than among control individuals without PEX. Design, Setting, and Participants: This cross-sectional analysis of patients recruited into the Aravind Pseudoexfoliation study included South Indian patients older than 40 years with or without PEX who required cataract surgery...
April 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28273987/visual-outcome-of-phacoemulsification-versus-small-incision-cataract-surgery-in-pseudoexfoliation-syndrome-a-pilot-study
#19
Anmol Ulhas Naik, Shveta Bhimashankar Gadewar
INTRODUCTION: Available data has highlighted the efficacy of both Phacoemulsification (PHACO) and Small Incision Cataract Surgery (SICS) in the presence of Pseudoexfoliation (PEX) syndrome. In developing countries, both are commonly performed procedures for cataract extraction. But, no direct comparison between these two procedures is available in the setting of PEX syndrome. With this lacuna in mind, this pilot study decided to compare the visual outcomes of both these techniques in the setting of PEX syndrome...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28258400/a-review-of-selective-laser-trabeculoplasty-recent-findings-and-current-perspectives
#20
REVIEW
Yujia Zhou, Ahmad A Aref
Selective laser trabeculoplasty (SLT) has been widely used in the clinical management of glaucoma, both as primary and adjunctive treatment. As new evidence continues to arise, we review the current literature in terms of indications and efficacy, surgical technique, postoperative care, repeatability, and complications of this therapy. SLT has been shown to be effective in various glaucomas, including primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), steroid-induced glaucoma, pseudoexfoliation glaucoma (PXFG), and primary angle-closure glaucoma (PACG), as well as other glaucoma subtypes...
March 3, 2017: Ophthalmology and Therapy
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