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pseudoexfoliation

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https://www.readbyqxmd.com/read/28644852/comparisons-of-retinal-vessel-diameter-and-glaucomatous-parameters-between-both-eyes-of-subjects-with-clinically-unilateral-pseudoexfoliation-syndrome
#1
Yasuyuki Takai, Masaki Tanito, Tetsuro Omura, Ryo Kawasaki, Yumiko Kawasaki, Akihiro Ohira
PURPOSE: Pseudoexfoliation syndrome (PEX), the most common identifiable cause of open-angle glaucoma, might affect the retinal hemodynamics. To test this, we compared retinal vessel diameter and glaucoma-related parameters between eyes with pseudoexfoliation material (PE+) and fellow unaffected (PE-) eyes of patients with clinically unilateral PEX. METHODS: The medical records of 30 consecutive Japanese subjects were reviewed retrospectively. The retinal vessel diameters were measured and expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) using standardized software...
2017: PloS One
https://www.readbyqxmd.com/read/28624324/risk-factors-for-rapid-glaucoma-disease-progression
#2
Thomas Chun Wai Chan, Chandra Bala, Anna Siu, Fiona Wan, Andrew White
PURPOSE: To determine the intraocular and systemic risk factor differences between a cohort of rapid glaucoma disease progressors and non-rapid disease progressors. DESIGN: Retrospective case control study Methods SETTING: Five private ophthalmology clinics STUDY POPULATION: 48 rapidly progressing eyes (progression ≥1dB mean deviation (MD)/year) and 486 non-rapidly progressing eyes (progression <1dB MD/year). Patients were eligible if they had a diagnosis of glaucoma from their ophthalmologist and if they had greater than or equal to 5 Humphrey visual fields (24-2) conducted...
June 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28622050/serum-and-aqueous-humor-levels-of-fetuin-a-in-pseudoexfoliation-syndrome
#3
Nilay Yuksel, Tamer Takmaz, Ummuhani Ozel Turkcu, Merve Ergin, Hasan Altinkaynak, Ayse Bilgihan
PURPOSE: To evaluate serum and aqueous humor levels of fetuin-A in patients with pseudoexfoliation syndrome (PEXS) in comparison with those of age- and sex-matched healthy subjects. MATERIALS AND METHODS: This prospective study included 25 patients with PEXS and 25 control subjects who were undergoing cataract surgery without any systemic or ocular disease. Aqueous humor and serum fetuin-A levels were measured with enzyme-linked immunosorbent assay method. RESULTS: The mean age of the PEXS group (14 males, 11 females, n = 25) was 57...
June 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28617722/prevalence-of-pseudoexfoliation-syndrome-in-an-isolated-island-population-of-korea-the-woodo-study
#4
Sang-Yoon Lee, Seondo Kim, Jeong Hong Kim, Sung-Chul Hong, Keun Hwa Lee, Hye-Sook Lee, Aesun Shin, Jinho Jeong
PURPOSE: To determine the prevalence and clinical characteristics of pseudoexfoliation syndrome (PXS) within Korean population living in Woodo Island. METHODS: Among the 625 residents aged 50 years or older, 305 residents (197 women and 108 men) participated in the study; a response rate of 48.8%. Participants filled out questionnaires on life style. Intraocular pressure and corneal endothelial cell function was measured. Both pupils were dilated. Fundus photographs and stereo disc photographs were taken...
June 14, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28614223/trabectome-success-factors
#5
Constance O Okeke, Eydie Miller-Ellis, Mario Rojas
Our objective is to investigate which factors and patient characteristics are associated with success in Trabectome surgery.A total of 658 phakic cases with at least of 12 months follow-up were included in the analysis. Baseline demographics and medical data were collected. The main outcome measure was intraocular pressure (IOP), glaucoma medication (Rx), and secondary glaucoma surgery if any. Success was defined as IOP reduction of 20% or more from preoperative IOP and IOP < 21 mm Hg with no secondary surgery throughout the follow-up period...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28604573/pupillometry-as-a-screening-tool-to-detect-pseudoexfoliation-syndrome
#6
Erdogan Yasar, Nilgun Yildirim, Eray Atalay, Emre Tambova, Ertugrul Colak
PURPOSE: Our objective was to evaluate the diagnostic value of a handheld pupillometer in differentiating eyes with pseudoexfoliation syndrome (PXS) from healthy controls. METHODS: This population-based, cross-sectional study was conducted in the province of Eskisehir, Turkey. Subjects 40 years of age and older were randomly recruited using stratified two-stage cluster sampling from the database of the Turkish Statistical Institute office in Eskisehir. Recruitment took place between June and October 2014...
June 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28602322/trabecular-microbypass-stent-implantation-with-cataract-extraction-in%C3%A2-pseudoexfoliation-glaucoma
#7
Tanner J Ferguson, Russell Swan, Mitch Ibach, Justin Schweitzer, Ramu Sudhagoni, John P Berdahl
PURPOSE: To evaluate the safety and efficacy of a trabecular microbypass stent (iStent) combined with cataract surgery in patients with pseudoexfoliation glaucoma (PXG). SETTING: Vance Thompson Vision, Sioux Falls, South Dakota, USA. DESIGN: Retrospective case series. METHODS: Eyes with PXG had implantation of 1 stent. Data were collected preoperatively and postoperatively through 24 months. Data included intraocular pressure (IOP), number of glaucoma medications, the incidence of postoperative IOP pressure spikes of 15 mm Hg or higher at any timepoint, and the need for additional surgery...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28600745/safety-and-effectiveness-of-gold-glaucoma-micro-shunt-for-reducing-intraocular-pressure-in-japanese-patients-with-open-angle-glaucoma
#8
Masaki Tanito, Etsuo Chihara
PURPOSE: To assess the safety and effectiveness of the SOLX gold shunt (GS) in reducing intraocular pressure (IOP) in Japanese patients with open angle glaucoma (OAG). METHODS: 24 eyes of 24 subjects [mean age of 68.9 ± 12.7 years; 13 (54%) women; 16 (67%) POAG, 7 (29%) pseudoexfoliation glaucoma, and 1 (4%) steroid response glaucoma] were implanted with the GS either with or without cataract surgery. Best-corrected visual acuity (BCVA), IOP, corneal endothelial cell density (CECD), anterior chamber (AC) flare, surgical complications, and required interventions were monitored at baseline, and 1 day, 1 week, 1, 3 and 6 months, and 1 year postoperatively...
June 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28586796/functional-activity-of-matrix-metalloproteinases-2-and-9-in-tears-of-patients-with-glaucoma
#9
Prity Sahay, Aparna Rao, Debananda Padhy, Sarada Sarangi, Gopinath Das, Mamatha M Reddy, Rahul Modak
Purpose: To evaluate the differential expression of tear matrix metalloproteinases (MMP) 2 and 9 in of patients with various forms of glaucoma. Methods: Tear samples were collected with a Schirmer's strip from 148 eyes of 113 patients (medically naïve patients with primary open-angle [POAG] or angle closure glaucoma [PACG] and those with pseudoexfoliation syndrome [PXF] or glaucoma [PXG]). These were compared to patients undergoing cataract surgery (controls) for this cross-sectional study...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28571835/-cataract-surgery-among-50-alzheimer-s-patient-55-eyes
#10
B Girard, B Chouard, F Hardy
OBJECTIVE: Cataract surgery for 50 Alzheimer patients (55 eyes). METHODS: Cinquante Alzheimer's patients with 0≤MMS≤25, with bilateral disabling cataracts were included for surgery. The surgical technique is analyzed. RESULTS AND CONCLUSION: The preoperative examination of Alzheimer's patients is time consuming and requires experience in this area, which is important to integrate into the practice of ophthalmology. The type of cataract is unusual, with a predilection for pseudoexfoliation syndrome and zonular fragility that has to be managed during surgery...
May 29, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28546930/implantation-of-trabecular-micro-bypass-stent-using-a-novel-landing-strip-technique
#11
Cindy X Zheng, Marlene R Moster, Priyanka Gogte, Yang Dai, Remy S Manzi, Michael Waisbourd
AIM: To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent (iStent) implantation in patients who underwent phacoemulsification. METHODS: Thirty-four eyes from 30 patients who underwent iStent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All iStents were implanted via the "landing strip" technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546927/safety-of-hydroimplantation-in-cataract-surgery-in-patients-with-pseudoexfoliation-syndrome
#12
Tevfik Oğurel, Reyhan Oğurel, Zafer Onaran, Kemal Örnek
AIM: To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome. METHODS: This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens (IOL). Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1 (n=50), and hydroxypropylmethylcellulose (Eyevisc, Biotech, India) was used in group 2 (n=50)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28540007/anterior-chamber-depth-change-following-cataract-surgery-in-pseudoexfoliation-syndrome-a-preliminary-study
#13
Mohammad Reza Fallah Tafti, Hossein Abdollah Beiki, S Farzad Mohammadi, Golshan Latifi, Elham Ashrafi, Zahra Fallah Tafti
PURPOSE: To assess the pseudophakic anterior chamber depth (PP-ACD) or effective lens position (ELP) change after cataract surgery in patients with pseudoexfoliation syndrome (PEX). METHODS: Consecutive eyes with PEX and cataract underwent standard phacoemulsification and were implanted with single-piece acrylic posterior chamber intraocular lenses (IOLs). Eyes with severe PEX and with axial length (AL) greater than 24 mm or less than 22 mm were not included. Eyes with capsular complication or unstable bags that needed capsular tension ring insertion were excluded...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28534485/pseudoexfoliation-syndrome-associated-genetic-variants-affect-transcription-factor-binding-and-alternative-splicing-of-loxl1
#14
Francesca Pasutto, Matthias Zenkel, Ursula Hoja, Daniel Berner, Steffen Uebe, Fulvia Ferrazzi, Johannes Schödel, Panah Liravi, Mineo Ozaki, Daniela Paoli, Paolo Frezzotti, Takanori Mizoguchi, Satoko Nakano, Toshiaki Kubota, Shinichi Manabe, Erika Salvi, Paolo Manunta, Daniele Cusi, Christian Gieger, Heinz-Erich Wichmann, Tin Aung, Chiea Chuen Khor, Friedrich E Kruse, André Reis, Ursula Schlötzer-Schrehardt
Although lysyl oxidase-like 1 (LOXL1) is known as the principal genetic risk factor for pseudoexfoliation (PEX) syndrome, a major cause of glaucoma and cardiovascular complications, no functional variants have been identified to date. Here, we conduct a genome-wide association scan on 771 German PEX patients and 1,350 controls, followed by independent testing of associated variants in Italian and Japanese data sets. We focus on a 3.5-kb four-component polymorphic locus positioned spanning introns 1 and 2 of LOXL1 with enhancer-like chromatin features...
May 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28534232/spontaneous-dislocation-of-the-posterior-chamber-intraocular-lens
#15
Azusa Fujikawa, Yasser Helmy Mohamed, Hirofumi Kinoshita, Eiko Tsuiki, Takashi Kitaoka
AIM: To evaluate the possible risk factors for posterior chamber intraocular lens dislocation either in-the-bag (ITB) dislocation or out-of-the-bag (OOTB) dislocation. METHODS: All subjects who sustained late intraocular lens dislocation from January 2011 until May 2014 and presented to the Nagasaki University Hospital were included in the study. This study is a retrospective evaluation of all cases of posterior chamber intraocular lens dislocation in this defined period...
May 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28503365/genetics-diagnosis-and-monitoring-of-pseudoexfoliation-glaucoma
#16
Niraj Nathan, Rachel W Kuchtey
Recent studies have shed new light on the genetic factors underlying pseudoexfoliation syndrome, growing our understanding of the role of the lysyl oxidase-like 1 (LOXL1) gene and its various polymorphisms as well as identifying new genetic associations. Recent years have brought new insight on how these genetic factors interact with other factors, including environmental, to confer risk to individuals and populations worldwide. All of these findings may hold importance to the screening, diagnosis, and monitoring of pseudoexfoliation and may also help lead to the identification of novel therapeutic targets...
December 2016: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28465815/levels-of-cytokines-in-the-aqueous-humor-of-eyes-with-primary-open-angle-glaucoma-pseudoexfoliation-glaucoma-and-cataract
#17
Nervana Khalef, Hany Labib, Hazem Helmy, Mona Abd El Hamid, Leqaa Moemen, Iman Fahmy
OBJECTIVE: The focus of this study aimed at measuring multiple inflammatory cytokines levels in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PEXG) and senile cataract. METHODS: This case control study was conducted at the Research Institute of Ophthalmology, Giza, Egypt in 2016. Aqueous humor (AH) samples were withdrawn from 50 patients (30 POAG, and 20 PEXG) and from 15 patients with senile cataract serving as controls...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28458512/no-differences-in-central-corneal-thickness-between-open-angle-and-pseudoexfoliation-glaucoma-patients
#18
Marcelo Ayala, Johanna Karlsson
INTRODUCTION: Measurements of intraocular pressure (IOP) with Goldmann applanation tonometry are affected by central corneal thickness (CCT), as thinner corneas underestimate and thicker corneas overestimate the true IOP value. The literature is controversial regarding CCT values in patients with primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG). The aim of this study was to evaluate CCT in patients with XFG and POAG. METHODS: CCT was evaluated with optical coherence tomography (OCT)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28457115/pseudoexfoliation-an-ocular-finding-with-possible-systemic-implications
#19
REVIEW
Uri Aviv, Daniel Ben Ner, Nardeen Sharif, Zvi Gur, Asaf Achiron
Pseudoexfoliation syndrome (PES) is a common age-related disorder affecting 60-70 million people worldwide. Patients with PES have abnormal production and deposition of fibrillar material in the anterior chamber of the eye. These exfoliated fibrils, easily detected by ocular slit-lamp examination, have also been found to exist systematically in the skin, heart, lungs, liver and kidneys. Recently, myriad studies have associated PES with systemic conditions such as increased vascular risk, risk of dementia and inflammatory state...
January 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28450942/immunohistochemical-analysis-of-microsomal-glutathione-s-transferase-1-and-clusterin-expression-in-lens-epithelial-cells-of-patients-with-pseudoexfoliation-syndrome
#20
Joanna Stafiej, Marta Hałas-Wiśniewska, Magdalena Izdebska, Maciej Gagat, Dariusz Grzanka, Alina Grzanka, Grażyna Malukiewicz
Pseudoexfoliation syndrome (PEX) is an age-associated, sight disorder affecting elastic fibers in the eye and visceral organs but its exact etiology remains unknown. The purpose of the current study was to determine the morphology and ultrastructure of lens epithelial cells (LECs), and to use immunohistochemistry to examine localization of microsomal glutathione S-transferase 1 (MGST1) and clusterin. Anterior lens capsules were obtained from 24 patients (13 PEX and 11 controls) who underwent phacoemulsification...
March 2017: Experimental and Therapeutic Medicine
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