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pseudoexfoliation

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https://www.readbyqxmd.com/read/29044059/pathology-and-immunohistochemistry-of-capsular-bag-in-spontaneously-late-dislocated-capsular-bag-intraocular-lens-complex
#1
Harsha Bhattacharjee, Kasturi Bhattacharjee, Dipankar Das, Manpreet Singh, Piruthivi Sukumar, Diva Kant Misra
PURPOSE: Our study aims to evaluate the morphology, histopathology, and immunohistochemistry of the spontaneously late dislocated capsular bag-intraocular lens (CB-IOL) complex. Various etiologies and possible pathogenesis of the event are also discussed. METHODS: This was a tertiary-care setting and retrospective observational case series. The surgically explanted intact specimens of spontaneously late dislocated CB-IOL complex were studied. The demographics, duration of pseudophakia, IOL design/material, and specimen measurements were noted...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29038959/the-effect-of-additional-trabecular-aspiration-to-phacoemulsification-and-trabectome-as-a-triple-procedure-in-pseudoexfoliation-glaucoma-a-case-matched-study
#2
R A Widder, J F Jordan, P Kühnrich, J Luebke, G F Roessler, A Anton
BACKGROUND: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees of the meshwork can be reached. This study was conducted to investigate the additional benefits and risks of adding trabecular aspiration to the combination of phacoemulsification and trabectome as a triple procedure...
October 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29030797/corneal-endothelial-changes-following-a-single-session-of-selective-laser-trabeculoplasty-for-pseudoexfoliative-glaucoma
#3
Nurgül Örnek, Kemal Örnek
PURPOSE: To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients. METHODS: Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees of inferior trabecular meshwork. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical, Hyogo, Japan)...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026286/intraoperative-optical-coherence-tomography-and-ab-interno-trabecular-meshwork-surgery-with-the-trabectome
#4
Bernd Junker, Jens F Jordan, Carsten Framme, Amelie Pielen
IMPORTANCE: This study is the first description of the use of the intraoperative optical coherence tomography (iOCT) for trabecular meshwork surgery with the Trabectome in a regular clinical setting. BACKGROUND: The aim of this study is to evaluate intraoperatively the immediate success of ab interno trabeculotomy with the Trabectome defined as a removal of the trabecular meshwork. DESIGN: This is a retrospective clinical study performed in the University Eye Hospital, Medical School Hannover...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28991617/goniotomy-with-a-single-use-dual-blade-short-term-results
#5
Michael D Greenwood, Leonard K Seibold, Nathan M Radcliffe, Syril K Dorairaj, Ahmad A Aref, Jesús Jimenez Román, Gabriel S Lazcano-Gomez, Jason K Darlington, Suhail Abdullah, Mark C Jasek, Khaled A Bahjri, John P Berdahl
PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of a single-use dual blade (Kahook) in patients with mild to end-stage glaucoma. SETTING: International multicenter ophthalmic care centers. DESIGN: Prospective interventional case series. METHODS: Consecutive patients with glaucoma who had phacoemulsification plus goniotomy with the single-use dual blade were enrolled in this study. Each center collected deidentified clinical data, including preoperative and postoperative IOP, medication use, adverse events, and whether additional surgery was required during a 6-month follow-up...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28984715/suprachoroidal-bleeding-after-xen-gel-implantation
#6
Verena Prokosch-Willing, Urs Vossmerbaeumer, Esther Hoffmann, Norbert Pfeiffer
PURPOSE: To report for the first time a clinical case of suprachoroidal bleeding after XEN45®gel implantation. OBSERVATIONS: A 84-year old female patient with pseudoexfoliation glaucoma with intraocular pressure (20 mm Hg) above target despite maximal IOP lowering therapy was scheduled for XEN45® gel implantation. The XEN45® gel implantation went without complications and was properly placed in the anterior chamber and beneath the conjunctiva. On the first postoperative day, the patient presented with an IOP of 4 mm Hg, a functioning bleb and a deep anterior chamber...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28984710/risk-factors-associated-with-glaucomatous-progression-in-pseudoexfoliation-patients
#7
Yeji Moon, Kyung Rim Sung, Joon Mo Kim, Seong Hee Shim, Chungkwon Yoo, Ji Hye Park
PURPOSE: To investigate risk factors associated with glaucomatous progression in pseudoexfoliation glaucoma (PXG) patients. PATIENTS AND METHODS: A retrospective observational study with a total of 48 PXG patients and age-, sex-, and visual-field (VF) test mean-deviation (MD)-matched 48 primary open angle glaucoma (POAG) patients recruited from three university-based hospitals. Glaucomatous progression was defined by two criteria, either optic disc/retinal nerve fiber layer photographic assessment or serial VF data...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28980566/-multi-level-analysis-of-the-prevalence-of-pseudoexfoliative-syndrome-and-pseudoexfoliative-glaucoma
#8
O N Kuleshova, E A Pichikova, A K Lasareva, S V Aydagulova, V V Dulidova, E V Egorova, V V Chernykh
Epidemiological investigation of pseudoexfoliative syndrome (PEX) as a glaucoma predictor is necessary for antiglaucoma treatment planning. AIM: To study the prevalence of PEX and pseudoexfoliative glaucoma (PXFG) among healthy people, naïve patients, and patients under observation as well as to evaluate the hypotensive efficacy of bimatoprost/timolol fixed combination (FCBT) over 4 months in PXFG. MATERIAL AND METHODS: Epidemiological analysis, ophthalmological examination, statistical analysis...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28979095/comparison-of-intraocular-pressure-fluctuations-before-and-after-ab-interno-trabeculectomy-in-pseudoexfoliation-glaucoma-patients
#9
Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi
PURPOSE: Ab interno trabeculectomy (AIT) with the Trabectome has been shown to reduce intraocular pressure (IOP) in eyes with pseudoexfoliation (PEX) glaucoma. Here, we examined the change of IOP fluctuations before and after only AIT or AIT with cataract surgery in PEX patients using the contact lens sensor Triggerfish(®). METHODS: This was a prospective open-label study. Twenty-four consecutive patients with PEX glaucoma were included. Twelve patients underwent cataract surgery and AIT (triple-surgery group), and 12 patients underwent only AIT (single-surgery group)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28973302/pseudoexfoliation-and-alzheimer-s-associated-clu-risk-variant-rs2279590-lies-within-an-enhancer-element-and-regulates-clu-ephx2-and-ptk2b-gene-expression
#10
Biswajit Padhy, Bushra Hayat, Gargi Gouranga Nanda, Pranjya Paramita Mohanty, Debasmita Pankaj Alone
Genetic variants at PTK2B-CLU locus pose as high risk factors for many age-related disorders. However, the role of these variants in disease progression is less characterized. In this study, we aimed to investigate the functional significance of a clusterin intronic SNP, rs2279590 that has been associated with pseudoexfoliation (PEX), Alzheimer's disease (AD), and diabetes. We have previously shown that the alleles at rs2279590 differentially regulate clusterin (CLU) gene expression in lens capsule tissues...
August 26, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28967074/palladium-103-plaque-radiation-therapy-for-ciliary-body-melanoma-through-a-functioning-glaucoma-filtering-bleb
#11
Arif H K Pathan, Alexander Barash, Lawrence B Tena, Paul T Finger
PURPOSE: To provide a clinical description of the long-term outcome of a 103Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb. METHODS: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension...
September 23, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944207/predictive-factors-of-visual-outcome-of-malaysian-cataract-patients-a-retrospective-study
#12
Thanigasalam Thevi, Myron Anthony Godinho
AIM: To explore the associations between various characteristics of Malaysian cataract patients and their management, and their post-operative visual outcomes, to inform relevant bodies to reduce cataract-related blindness. METHODS: We conducted a descriptive secondary data analysis of cataract surgery patients in Melaka Hospital, from 2007 to 2014 using the National Eye Database (NED). Patient-related factors (demographic features, systemic and ocular comorbidities) and management-related factors (surgical duration, type of surgery, type of lens) were analysed for their association with visual outcome (acuity)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944195/effect-of-phacoemulsification-on-intraocular-pressure-in-patients-with-primary-open-angle-glaucoma-and-pseudoexfoliation-glaucoma
#13
Jesus Jimenez-Roman, Gabriel Lazcano-Gomez, Karina Martínez-Baez, Mauricio Turati, Rosario Gulías-Cañizo, Luis F Hernández-Zimbrón, Lenin Ochoa-De la Paz, Rubén Zamora, Roberto Gonzalez-Salinas
AIM: To compare the effect of phacoemulsification on intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). METHODS: A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in Mexico. The study enrolled consecutive patients having phacoemulsification with intraocular lens (IOL) implantation and a diagnosis of POAG or PXG. Data about IOP values and number of glaucoma medications used was collected at baseline, 1, 3, 6 and 12mo postoperatively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28942471/an-unusual-complication-of-combined-gonioscopy-assisted-transluminal-trabeculotomy-and-phacoemulsification-vision-loss-due-to-intracapsular-hematoma
#14
Duygu Yalinbas, Zeynep Aktas, İbrahim Hepsen, Nilay Dilekmen
PURPOSE: To report two cases with an acute vision loss due to intracapsular hemorrhage (hematoma) after an uncomplicated gonioscopy-assisted transluminal trabeculotomy (GATT) combined with phacoemulsification surgery. METHODS: Case report. RESULTS: Seventy-six-year-old male and 75-year-old female patients with cataract and pseudoexfoliative glaucoma (XFG) uncontrolled with maximum medical therapy both underwent GATT combined with phacoemulsification...
September 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28937506/role-of-lens-extraction-and-laser-peripheral-iridotomy-in-treatment-of-glaucoma
#15
Sara Pose-Bazarra, Augusto Azuara-Blanco
PURPOSE OF REVIEW: Lens extraction in people with coexisting cataract and open angle glaucoma is associated with a reduction in intraocular pressure (IOP). In primary angle-closure glaucoma (PACG), lens extraction and laser peripheral iridotomy (LPI) can be used to open the anterior chamber angle, increase the outflow through the trabecular meshwork and reduce the IOP. The present review will summarize the recent available literature regarding the role of both interventions for the treatment of glaucoma...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28917406/comparison-of-the-mechanical-properties-of-the-anterior-lens-capsule-in-senile-cataract-senile-cataract-with-trypan-blue-application-and-pseudoexfoliation-syndrome
#16
Cem Simsek, Sibel Oto, Gursel Yilmaz, Dilek Dursun Altinors, Ahmet Akman, Sirel Gur Gungor
PURPOSE: To evaluate the elastic modulus, hardness, and mechanical properties of the anterior lens capsule in different types of cataract and to assess the correlation with age. SETTING: Baskent University Hospital, Department of Ophthalmology, Ankara, Turkey. DESIGN: Prospective comparative study. METHODS: Patients were divided into 3 groups. Group 1 comprised patients with senile cataract, Group 2 patients had pseudoexfoliation (PXF) syndrome, and Group 3 patients had dye-enhanced cataract surgery...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28910163/anterior-lens-capsule-and-iris-thicknesses-in-pseudoexfoliation-syndrome
#17
Muhammed Batur, Erbil Seven, Serek Tekin, Tekin Yasar
PURPOSE: The aim of this study was to evaluate anatomic properties of the lens capsule and iris by anterior segment optical coherence tomography (AS-OCT) in patients with pseudoexfoliation (PEX). METHODS: This prospective study included 62 eyes of 62 patients with PEX syndrome and 43 eyes of 43 age- and gender-matched controls. All subjects underwent full ophthalmologic examinations including AS-OCT. Pupillary diameter, midperipheral stromal iris thickness, central and temporal lens capsule thicknesses, and peripheral pseudoexfoliation material thickness on the anterior lens capsule surface were measured and recorded...
November 2017: Current Eye Research
https://www.readbyqxmd.com/read/28887138/-the-role-of-phacoemulsification-in-glaucoma-therapy-a-systematic-review-and-meta-analysis
#18
REVIEW
Marisse Masis, Patrick J Mineault, Eileen Phan, Shan C Lin
Cataract extraction is a safe and effective surgery that has been performed in its modern form for several decades. Many studies have noted that cataract extraction could also have a clinically significant role in the control of co-morbid glaucoma. Lens extraction decreases the pressure within the eye, and intraocular pressure is the only controllable risk factor in glaucoma proven to be effective. A systematic analysis of current evidence is needed to establish strong practice patterns and identify areas where further research is required...
September 5, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28877529/retinal-nerve-fiber-layer-thickness-changes-in-the-pseudoexfoliation-syndrome-a-meta-analysis-of-case-control-studies
#19
Ji-Guo Yu, Qing Huang, Xiao-Fang Zhou, Yi Ding, Jing Li, Yi Xiang
PURPOSE: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls. METHODS: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale...
September 7, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28858961/short-term-results-of-trabeculectomy-using-adjunctive-intracameral-bevacizumab-versus-mitomycin-c-a-randomized-controlled-trial
#20
Zakieh Vahedian, Mostafa Mafi, Ghasem Fakhraie, Reza Zarei, Yadollah Eslami, Hadi Ghadimi, Masomeh Mohebbi
PURPOSE: To compare the outcome of trabeculectomy using adjunctive intracameral bevacizumab versus intraoperative mitomycin C (MMC). MATERIALS AND METHODS: In this double-blind, randomized clinical trial 87 eyes of 87 patients with primary open-angle or pseudoexfoliation glaucoma were assigned to each treatment group (44 cases received 1.25 mg intracameral bevacizumab at the end of operation and in 43 cases MMC was applied during surgery). Success was defined as intraocular pressure (IOP) between 6 and 21 mm Hg and at least 30% IOP drop with (qualified) or without (complete) glaucoma medications without additional glaucoma surgery...
August 30, 2017: Journal of Glaucoma
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