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pseudoexfoliation

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https://www.readbyqxmd.com/read/29450398/cataract-surgery-outcome-in-patients-with-non-glaucomatous-pseudoexfoliation
#1
Praveen Venkatesha Sastry, Anuj Kumar Singal
Aim. To study the outcome of cataract surgery in eyes with pseudoexfoliation without signs of glaucoma. Methods. This prospective study was done over nine months on patients with pseudoexfoliation undergoing small incision cataract surgery. Only patients with normal intraocular pressure (Central Corneal Thickness Corrected), normal cup disc ratio and open angles were included. Patients on anti-glaucoma medication were excluded. Patients underwent surgery performed by a single senior surgeon. Intraoperative and postoperative day (POD) 1 findings were noted...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29448287/-significance-of-homocysteine-in-glaucoma
#2
Anselm Jünemann, Robert Rejdak, Bettina Hohberger
Endothelial dysfunction and vascular dysregulation play a role in the multifactorial pathogenesis of glaucomatous optic nerve atrophy. Hyperhomocysteinemia is a risk factor for endothelial dysfunction and is associated with primary open-angle glaucoma as well as secondary open-angle glaucoma in the pseudoexfoliation syndrome. This paper reviews the literature on the association between homocysteine metabolism and glaucomatous disease and explains the possible role of hyperhomocysteinemia in the pathogenesis and progression of glaucoma...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29426445/evaluating-selective-laser-trabeculoplasty-versus-argon-laser-trabeculoplasty-in-pseudoexfoliation-glaucoma-patients
#3
Jin Soo A Song, Jayme Vianna, Lesya Shuba, Paul Rafuse, Marcelo Nicolela
OBJECTIVE: Laser trabeculoplasty effectively reduces intraocular pressure (IOP) in primary open angle glaucoma, with argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) showing equivalent outcomes. However, it is unclear which laser modality is more effective in pseudoexfoliation (PXE) glaucoma. This study aims to compare the effectiveness of ALT and SLT in PXE glaucoma. DESIGN: Retrospective cohort study. METHODS: A chart review evaluating patients diagnosed with PXE glaucoma and treated with laser trabeculoplasty from 2005-2015...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29425386/rotational-stability-of-monofocal-and-trifocal-intraocular-toric-lenses-with-identical-design-and-material-but-different-surface-treatment
#4
Kristof Vandekerckhove
PURPOSE: To compare the rotational stability, total misalignment, and visual and refractive outcomes achieved with a trifocal toric versus a monofocal toric intraocular lens (IOL). METHODS: In this prospective, interventional case series, eyes of patients consecutively scheduled for cataract surgery who had clinically relevant astigmatism were implanted with a FineVision Pod FT trifocal toric IOL or an Ankoris monofocal toric IOL (both PhysIOL SA, Liège, Belgium)...
February 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29398902/elevated-levels-of-plasma-tumor-necrosis-factor-alpha-in-patients-with-pseudoexfoliation-glaucoma
#5
Altaf A Kondkar, Taif A Azad, Faisal A Almobarak, Hatem Kalantan, Saleh A Al-Obeidan, Khaled K Abu-Amero
Background: Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine, which plays a role in glaucomatous neurodegeneration. Based on the plausible role of inflammation in the pathogenesis of pseudoexfoliation glaucoma (PEG), we investigated whether there is any relationship between the levels of plasma TNF-α and PEG or any of its clinical indices in comparison to normal controls. Methods: The study was designed as a retrospective analysis. Plasma samples from 49 PEG patients and 88 non-glaucomatous controls were evaluated for TNF-α levels using an enzyme-linked immunosorbent assay (ELISA)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29375993/comparison-of-long-term-results-of-trabeculectomy-to-treat-pseudoexfoliative-glaucoma-and-primary-open-angle-glaucoma
#6
Vuslat Pelitli Gürlü, Hande Güçlü, Altan Özal, Ömer Benian, Levent Alimgil
AIM: To compare the long term outcome of trabeculectomy in patients with pseudoexfoliative glaucoma (PEG) and primary open angle glaucoma (POAG) in terms of surgical success. METHODS: The success of the trabeculectomy was evaluated by three criteria. Criterion A: intraocular pressure (IOP) ≤21 mm Hg and decrease in IOP ≥20%; Criterion B: IOP ≤18 mm Hg and decrease in IOP ≥30%; Criterion C: IOP ≤15 mm Hg and decrease in IOP ≥50%. Patients that met these criteria without medical treatment were considered to be completely successful, while those that met these criteria with medical treatment were considered partially successful...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29362155/pseudoexfoliation-syndrome-without-glaucoma-white-matter-abnormalities-detected-by-conventional-mri-and-diffusion-tensor-imaging
#7
Anastasia K Zikou, George Kitsos, Loukas G Astrakas, Vasileios G Xydis, Konstantinos Spiliopoulos, Eleni Bagli, Maria I Argyropoulou
PURPOSE: To assess macro- and microstructural brain changes in patients with pseudoexfoliation syndrome (PXS). MATERIALS AND METHODS: Comprehensive ophthalmic examination and brain MRI were conducted on 20 patients with PXS without glaucoma (aged 62.75 ± 0.4 years) and 20 controls (aged 62 ± 0.6 years). White matter (WM) integrity was evaluated on FLAIR and single-shot multisection SE-EPI diffusion tensor imaging (DTI) sequences. The presence and the number of white matter hyperintensities (WMHIs) on FLAIR images was compared between all patients and control subjects...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29335101/outcomes-and-complication-rates-of-primary-resident-performed-cataract-surgeries-at-a-large-tertiary-care-county-hospital
#8
Cameron Clarke, Shazia F Ali, Michael Murri, Saagar N Patel, Li Wang, Marie Tuft, Mitchell P Weikert, Zaina Al-Mohtaseb
PURPOSE: To identify the preoperative risk factors, intraoperative events, and postoperative complications increasing the risk for poor visual outcomes in resident-performed cataract surgeries at a tertiary-care county hospital. SETTING: Ben Taub General Hospital, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Resident-performed cataract surgeries were analyzed for risk factors, comorbidities, and intraoperative and postoperative complications...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29330811/a-nationwide-survey-of-factors-influencing-adherence-to-ocular-hypotensive-eyedrops-in-japan
#9
Toyoaki Tsumura, Kenji Kashiwagi, Yasuyuki Suzuki, Keiji Yoshikawa, Hirotaka Suzumura, Toshine Maeda, Ryuji Takeda, Hitomi Saito, Makoto Araie
INTRODUCTION: Few reports have investigated the status of adherence in Japan on a large scale. We aimed to investigate the status of adherence to topical glaucoma treatment and its associated factors. METHODS: A nationwide survey was conducted as a prospective fashion. Participants in this survey were subjects with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension or pseudoexfoliation glaucoma who had been prescribed anti-glaucoma ophthalmic eyedrops and whose ophthalmologist considered prescribing any fixed combination of ocular hypotensive eyedrops for the first time between 2011 and 2012...
January 12, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29329947/-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#10
REVIEW
C Schweitzer
Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material...
January 9, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29304261/an-evaluation-of-the-relationship-between-clinically-unilateral-pseudoexfoliation-syndrome-and-age-related-macular-degeneration
#11
Mehmet Ozgur Zengin, Omer Karti, Eyyup Karahan, Tuncay Kusbeci
BACKGROUND AND OBJECTIVE: To evaluate the relationship between age-related macular degeneration (AMD) and clinically unilateral pseudoexfoliation syndrome (XFS). PATIENTS AND METHODS: Seventy-six patients (152 eyes) with bilateral AMD and clinically unilateral XFS were included. Eyes with AMD were divided into three stages (early, intermediate, and late), based on the Beckman Initiative for Macular Research Classification Committee of fundus findings. The distribution of AMD lesions was assessed in both groups, and the subfoveal choroidal thickness (SFCT) was measured using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT)...
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29300213/chronic-and-intermittent-angle-closure-caused-by-in-the-bag-capsular-tension-ring-and-intraocular-lens-dislocation-in-patients-with-pseudoexfoliation-syndrome-erratum
#12
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29290014/three-year-results-of-ab-interno-trabeculectomy-trabectome-berlin-study-group
#13
Milena Pahlitzsch, Anja M Davids, Malte Zorn, Necip Torun, Sibylle Winterhalter, Anna-Karina B Maier, Matthias K Klamann, Eckart Bertelmann
PURPOSE: To assess the long-term outcome of Trabectome surgery in the treatment of primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX): 3-year results. METHODS: Trabectome surgery (NeoMedix, Tustin, CA, USA) was performed in 268 POAG patients (women 57.46%, men 42.54%, age 72.35 ± 9.63 years) and 98 PEX glaucoma patients (women 58.16%, men 41.84%, age 73.42 ± 8.54 years), and uncontrolled intraocular pressure (IOP). Parameters were examined preoperatively, 1 day, 6 weeks, 3, 6, 12, 24 and 36 months post surgery...
December 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29278698/gwas-links-variants-in-neuronal-development-and-actin-remodeling-related-loci-with-pseudoexfoliation-syndrome-without-glaucoma
#14
Katarzyna Zagajewska, Magdalena Piątkowska, Krzysztof Goryca, Aneta Bałabas, Anna Kluska, Agnieszka Paziewska, Ewelina Pośpiech, Iwona Grabska-Liberek, Ewa E Hennig
Pseudoexfoliation syndrome (PEXS) is an age-related elastosis, strongly associated with the development of secondary glaucoma. It is clearly suggested that PEXS has a genetic component, but this has not been extensively studied. Here, a genome-wide association study (GWAS) using a DNA-pooling approach was conducted to explore the potential association of genetic variants with PEXS in a Polish population, including 103 PEXS patients without glaucoma and 106 perfectly (age- and gender-) matched controls. Individual sample TaqMan genotyping was used to validate GWAS-selected single-nucleotide polymorphism (SNP) associations...
December 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29274987/anterior-capsulorhexis-opening-reduction-after-cataract-surgery-with-subluxated-lenses
#15
Juris Vanags, Renārs Erts, Guna Laganovska
BACKGROUND AND OBJECTIVE: This study sought to evaluate anterior capsulorhexis opening (ACO) reductions after surgery for a subluxated lens. Significant reduction of an ACO supports direct zonular involvement (capsular factors excluded by use of capsular tension rings [CTRs] and modern intraocular lens [IOLs]), and these findings question the long-term efficacy of subluxated lens surgery by means of cataract surgery. A small ACO due to lens mobility, non-enlargement of the ACO, and no lens epithelial cell washing due to an additional risk of further zonular damage were left as additional features to evaluate the possible outcomes of this simplified but still complicated surgery...
December 14, 2017: Medicina
https://www.readbyqxmd.com/read/29274019/switch-from-bak-preserved-to-preservative-free-latanoprost-decreases-anterior-chamber-flare-in-poag-patients
#16
Ph A Kestelyn, Ph G Kestelyn, D De Bacquer, A M Stevens
PURPOSE: To validate the hypothesis that BAK induces low-grade inflammation in the anterior chamber, we designed a study to investigate whether switching from BAK-preserved to preservative-free latanoprost in patients with primary open-angle glaucoma (POAG) would reduce the flare levels. PATIENTS: Forty-one eyes of twenty-two patients with primary open-angle glaucoma treated with BAK-preserved latanoprost for at least 6 months as monotherapy were included. Exclusion criteria included any use of topical eye drops other than latanoprost, pseudoexfoliation and pigment dispersion glaucoma, wearing of contact lenses and intraocular surgery in the past year...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260501/central-corneal-thickness-and-corneal-volume-changes-in-eyes-with-and-without-pseudoexfoliation-after-uneventful-phacoemulsification
#17
Yonca Asfuroglu, Ozlem Evren Kemer
AIM: To investigate the effects of uneventful phacoemulsification on central corneal thickness (CCT) and corneal volume (CV) in pseudoexfoliative eyes during a 3 months postoperative period and compare these changes to eyes without pseudoexfoliation (PEX) syndrome. Another purpose of this study was to compare the CCT measurements done by ultrasound pachymetry (UP) with those done by the Oculus Pentacam. MATERIAL AND METHOD: A total of 42 eyes of 42 consecutive patients with cataracts and PEX syndrome that underwent uneventful phacoemulsification were enrolled in this prospective study...
December 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260496/evaluation-of-cntnap2-gene-rs2107856-polymorphism-in-turkish-population-with-pseudoexfoliation-syndrome
#18
Irmak Karaca, Suzan Guven Yilmaz, Melis Palamar, Huseyin Onay, Bilcag Akgun, Burcu Aytacoglu, Ayca Aykut, Feristah Ferda Ozkinay
PURPOSE: To investigate rs2107856 single-nucleotide polymorphism (SNP) of CNTNAP2 gene in Turkish population with pseudoexfoliation and to correlate clinical characteristics with the genotypic profile. MATERIALS AND METHODS: Forty-three patients with pseudoexfoliation syndrome (PXS), 46 patients with pseudoexfoliation glaucoma (PXG) and 99 healthy controls were enrolled. Comprehensive ophthalmological examination, central corneal thickness measurement and retinal nerve fiber layer thickness analysis of the peripapillary area were performed...
December 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29225964/chosen-vascular-risk-markers-in-pseudoexfoliation-syndrome-an-age-related-disorder
#19
Hanna Lesiewska, Agnieszka Łukaszewska-Smyk, Grażyna Odrowąż-Sypniewska, Magdalena Krintus, Aneta Mańkowska-Cyl, Grażyna Malukiewicz
Purpose: To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods: 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results: There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29200083/clinical-outcomes-and-intraocular-pressure-control-after-scleral-glued-intraocular-lens-insertion-in-eyes-with-pseudoexfoliation
#20
Ashwinee Ragam, David C Ritterband, Emily C Waisbren, Julia Mathew-Padiyedathu, Joann Kang, John A Seedor
PURPOSE: To analyze clinical outcomes and intraocular pressure (IOP) control following scleral-glued intraocular lens (IOL) fixation in eyes with pseudoexfoliation (PXF). METHODS: A retrospective chart review and outcome analysis was performed on a series of eyes undergoing glue-assisted, scleral-fixated ('scleral-glued') IOL insertion in the setting of PXF and poor or absent capsular support. RESULTS: 28 eyes were included in the study. The indications for scleral-glued IOL fixation included late endocapsular IOL dislocation (21/28, 75%), exchange for iris-fixated IOL due to complication (4/28, 14%), subluxed crystalline lens (2/28, 7%), and aphakia after complicated cataract surgery (1/28, 4%)...
December 1, 2017: Journal of Glaucoma
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