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https://www.readbyqxmd.com/read/28921867/polymer-cancerostatics-targeted-with-an-antibody-fragment-bound-via-a-coiled-coil-motif-in-vivo-therapeutic-efficacy-against-murine-bcl1-leukemia
#1
Michal Pechar, Robert Pola, Olga Janoušková, Irena Sieglová, Vlastimil Král, Milan Fábry, Barbora Tomalová, Marek Kovář
A BCL1 leukemia-cell-targeted polymer-drug conjugate with a narrow molecular weight distribution consisting of an N-(2-hydroxypropyl)methacrylamide copolymer carrier and the anticancer drug pirarubicin is prepared by controlled radical copolymerization followed by metal-free click chemistry. A targeting recombinant single chain antibody fragment (scFv) derived from a B1 monoclonal antibody is attached noncovalently to the polymer carrier via a coiled coil interaction between two complementary peptides. Two pairs of coiled coil forming peptides (abbreviated KEK/EKE and KSK/ESE) are used as linkers between the polymer-pirarubicin conjugate and the targeting protein...
September 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28920963/tuning-a-circular-p-n-junction-in-graphene-from-quantum-confinement-to-optical-guiding
#2
Yuhang Jiang, Jinhai Mao, Dean Moldovan, Massoud Ramezani Masir, Guohong Li, Kenji Watanabe, Takashi Taniguchi, Francois M Peeters, Eva Y Andrei
The photon-like propagation of the Dirac electrons in graphene, together with its record-high electronic mobility, can lead to applications based on ultrafast electronic response and low dissipation. However, the chiral nature of the charge carriers that is responsible for the high mobility also makes it difficult to control their motion and prevents electronic switching. Here, we show how to manipulate the charge carriers by using a circular p-n junction whose size can be continuously tuned from the nanometre to the micrometre scale...
September 18, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28918065/the-role-of-epigenetics-in-lysosomal-storage-disorders-uncharted-territory
#3
REVIEW
Shahzeb Hassan, Ellen Sidransky, Nahid Tayebi
The study of the contribution of epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, to human disease has enhanced our understanding of different cellular processes and diseased states, as well as the effect of environmental factors on phenotypic outcomes. Epigenetic studies may be particularly relevant in evaluating the clinical heterogeneity observed in monogenic disorders. The lysosomal storage disorders are Mendelian disorders characterized by a wide spectrum of associated phenotypes, ranging from neonatal presentations to symptoms that develop in late adulthood...
August 1, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28915871/virtual-patients-in-the-acquisition-of-clinical-reasoning-skills-does-presentation-mode-matter-a-quasi-randomized-controlled-trial
#4
Fabian Schubach, Matthias Goos, Götz Fabry, Werner Vach, Martin Boeker
BACKGROUND: The objective of this study is to compare two different instructional methods in the curricular use of computerized virtual patients in undergraduate medical education. We aim to investigate whether using many short and focused cases - the key feature principle - is more effective for the learning of clinical reasoning skills than using few long and systematic cases. METHODS: We conducted a quasi-randomized, non-blinded, controlled parallel-group intervention trial in a large medical school in Southwestern Germany...
September 15, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28914901/interaction-of-surface-plasmon-polaritons-and-acoustic-waves-inside-an-acoustic-cavity
#5
Nikolai Khokhlov, Grigoriy Knyazev, Boris Glavin, Yakov Shtykov, Oleg Romanov, Vladimir Belotelov
In this Letter, we introduce an approach for manipulation of active plasmon polaritons via acoustic waves at sub-terahertz frequency range. The acoustic structures considered are designed as phononic Fabry-Perot microresonators where mirrors are presented with an acoustic superlattice and the structure's surface, and a plasmonic grating is placed on top of the acoustic cavity so formed. It provides phonon localization in the vicinity of the plasmonic grating at frequencies within the phononic stop band enhancing phonon-light interaction...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914897/dual-frequency-doppler-lidar-for-wind-detection-with-a-superconducting-nanowire-single-photon-detector
#6
Mingjia Shangguan, Haiyun Xia, Chong Wang, Jiawei Qiu, Shengfu Lin, Xiankang Dou, Qiang Zhang, Jian-Wei Pan
A dual-frequency direct detection Doppler lidar is demonstrated using a superconducting nanowire single-photon detector (SNSPD) at 1.5 μm. The so-called double-edge technique is implemented by using a dual-frequency laser pulse, rather than using a double-channel Fabry-Perot interferometer. Such a modification to the reported lidars enhances the frequency stability in the system level. Using the time-division multiplexing method, only one piece of SNSPD is used in the optical receiver, making the system simplified and robust...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28913627/everolimus-eluting-bioresorbable-vascular-scaffold-in-daily-clinical-practice-a%C3%A2-single-centre-experience
#7
W S Remkes, R S Hermanides, M W Kennedy, E Fabris, E Kaplan, J P Ottervanger, A W J van 't Hof, E Kedhi
BACKGROUND: Recent evidence has raised concerns regarding the safety of the everolimus-eluting bioresorbable vascular scaffold (E-BVS) (Absorb, Abbott Vascular, Santa Clara, CA, USA). Following these data, the use of this device has diminished in the Netherlands; however, daily practice data are limited. Therefore we studied the incidence of safety and efficacy outcomes with this device in daily clinical practice in a single large tertiary centre in the Netherlands. METHODS: All E‑BVS treated patients were included in this analysis...
September 14, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28904400/enhanced-bandwidth-of-high-directive-emission-fabry-perot-resonator-antenna-with-tapered-near-zero-effective-index-using-metasurface
#8
Zhen-Guo Liu, Wei-Bing Lu, Wu Yang
In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring element and a PEC ground plate can be acted as an effective metamaterial media with very low refractive index (near zero index). According to Snell's theory, this property can be used to enhance the directive emission...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902648/-fabry-disease-an-overlooked-diagnosis-in-adult-cardiac-patients
#9
Meral Kayıkçıoğlu, Evrim Şimşek, Sema Kalkan Uçar, Selen Bayraktaroğlu, Hüseyin Onay, Eser Sözmen, Mahmut Çoker
Fabry disease is a rare, X-linked, lysosomal glycosphingolipid storage disorder. A deficiency of the enzyme alpha-galactosidase results in intracellular accumulation of globotriaosylceramide in multiple cell types, such as those of the nerves, kidneys, cardiac, and cutaneous tissues, leading to a multisystem disease. Male patients are more severely affected; however, heterozygous female patients may also be afflicted, though often the symptoms develop later. Cardiac involvement can include left ventricular hypertrophy, conduction abnormalities, arrhythmias, valvular abnormalities, and heart failure...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28900221/lasing-by-driven-atoms-cavity-system-in-collective-strong-coupling-regime
#10
Rahul Sawant, S A Rangwala
The interaction of laser cooled atoms with resonant light is determined by the natural linewidth of the excited state. An optical cavity is another optically resonant system where the loss from the cavity determines the resonant optical response of the system. The near resonant combination of an optical Fabry-Pérot cavity with laser cooled and trapped atoms couples two distinct optical resonators via light and has great potential for precision measurements and the creation of versatile quantum optics systems...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892806/a-novel-missense-gla-mutation-p-g35v-detected-in-hemodialysis-screening-leads-to-severe-systemic-manifestations-of-fabry-disease-in-men-and-women
#11
Valeria Soares Pigozzi Veloso, Thiago Lacerda Ataides, Maria Eugênia Fernandes Canziani, Mariana Pigozzi Veloso, Nilzio Antônio da Silva, Daniela Veit Barreto, Edna Regina Silva Pereira, Luiz Antonio Ribeiro de Moura, Fellype Carvalho Barreto
BACKGROUND/AIMS: Fabry disease (FD), an X-linked lysosomal storage disorder, leads to accumulation of globotriaosylceramide. Screening in dialysis patients may identify genetic variants of unknown clinical significance. We aimed to characterize the pathogenicity of a novel GLA gene mutation identified during hemodialysis screening and the histologic findings of early Fabry nephropathy. METHODS: One out of 108 male hemodialysis patients screened for FD presented low α-galactosidase A activity...
September 12, 2017: Nephron
https://www.readbyqxmd.com/read/28886650/a-general-variational-approach-for-computing-rovibrational-resonances-of-polyatomic-molecules-application-to-the-weakly-bound-h2he-and-h2%C3%A2-co-systems
#12
Dóra Papp, Tamás Szidarovszky, Attila G Császár
The quasi-variational quantum chemical protocol and code GENIUSH [E. Mátyus et al., J. Chem. Phys. 130, 134112 (2009) and C. Fábri et al., J. Chem. Phys. 134, 074105 (2011)] has been augmented with the complex absorbing potential (CAP) technique, yielding a method for the determination of rovibrational resonance states. Due to the effective implementation of the CAP technique within GENIUSH, the GENIUSH-CAP code is a powerful tool for the study of important dynamical features of arbitrary-sized molecular systems with arbitrary composition above their first dissociation limit...
September 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28880170/rapid-spatial-mapping-of-focused-ultrasound-fields-using-a-planar-fabry-p%C3%A3-rot-sensor
#13
Eleanor Martin, Edward Z Zhang, James A Guggenheim, Paul C Beard, Bradley E Treeby
Measurement of high acoustic pressures is necessary in order to fully characterise clinical high-intensity focused ultrasound (HIFU) fields, and for accurate validation of computational models of ultrasound propagation. However, many existing measurement devices are unable to withstand the extreme pressures generated in these fields, and those that can often exhibit low sensitivity. Here, a planar Fabry-Pérot interferometer with hard dielectric mirrors and spacer was designed, fabricated, and characterised and its suitability for measurement of nonlinear focused ultrasound fields was investigated...
September 4, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28878407/simultaneous-measurement-of-transverse-load-and-temperature-using-hybrid-structured-fiber-optic-fabry-perot-interferometer
#14
Yongfeng Wu, Yundong Zhang, Jing Wu, Ping Yuan
We experimentally demonstrated a novel fiber-optic hybrid structured Fabry-Perot interferometer with special air-cavity for simultaneous measurement of transverse load and temperature. By the linear phase finite impulse response filters, the transverse load sensitivities of the air-cavity and the silica-cavity are 1272.71 pm/N and -53.07 pm/N, respectively, and temperature sensitivities of the air-cavity and silica-cavity are 1.1 pm/°C and 14 pm/°C. Thus, the different sensitivities of silica-cavity and air-cavity to transverse load and temperature indicate that such a structure can be used to simultaneously measure transverse load and temperature...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877708/fabry-disease-and-incidence-of-cancer
#15
Sarah Bird, Efthymios Hadjimichael, Atul Mehta, Uma Ramaswami, Derralynn Hughes
BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder caused by deficient activity of α-galactosidase A and the resulting accumulation of the glycosphingolipid globotriaosylceramide (Gb3) and its derivatives, including globotriaosylsphingosine (Lyso-Gb3). Increased cellular and plasma levels of Gb3 and Lyso-Gb3 affect multiple organs, with specific clinical consequences for the kidneys, heart and brain. There is growing evidence that alterations in glycosphingolipids may have an oncogenic role and this prompted a review of cases of cancer and benign lesions in a large single centre cohort of Fabry patients...
September 6, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28874769/effect-of-surface-plasmon-coupling-to-optical-cavity-modes-on-the-field-enhancement-and-spectral-response-of-dimer-based-sensors
#16
Salma Alrasheed, Enzo Di Fabrizio
We present a theoretical approach to narrow the plasmon linewidth and enhance the near-field intensity at a plasmonic dimer gap (hot spot) through coupling the electric localized surface plasmon (LSP) resonance of a silver hemispherical dimer with the resonant modes of a Fabry-Perot (FP) cavity. The strong coupling is demonstrated by the large anticrossing in the reflection spectra and a Rabi splitting of 76 meV. Up to 2-fold enhancement increase can be achieved compared to that without using the cavity. Such high field enhancement has potential applications in optics, including sensors and high resolution imaging devices...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874696/metamaterial-perfect-absorber-analyzed-by-a-meta-cavity-model-consisting-of-multilayer-metasurfaces
#17
Khagendra Bhattarai, Sinhara Silva, Kun Song, Augustine Urbas, Sang Jun Lee, Zahyun Ku, Jiangfeng Zhou
We demonstrate that the metamaterial perfect absorber behaves as a meta-cavity bounded between a resonant metasurface and a metallic thin-film reflector. The perfect absorption is achieved by the Fabry-Perot cavity resonance via multiple reflections between the "quasi-open" boundary of resonator and the "close" boundary of reflector. The characteristic features including angle independence, ultra-thin thickness and strong field localization can be well explained by this meta-cavity model. With this model, metamaterial perfect absorber can be redefined as a meta-cavity exhibiting high Q-factor, strong field enhancement and extremely high photonic density of states, thereby promising novel applications for high performance sensor, infrared photodetector and cavity quantum electrodynamics devices...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871487/fabry-disease-in-children-a-federal-screening-programme-in-russia
#18
Leyla Seymurovna Namazova-Baranova, Alexander Alexandrovich Baranov, Aleksander Alekseevich Pushkov, Kirill Victorovich Savostyanov
Our objective was to examine the prevalence of Fabry disease in Russian children with chronic pain in the distal limbs. This non-interventional, multi-centre study included children 2-18 years of age with chronic recurrent unilateral or bilateral pain, burning, or acroparesthesia in the hands or feet. The presence of Fabry disease was defined by abnormal alpha-galactosidase A activity in males or alpha-galactosidase gene (GLA) mutation in females. Among 214 patients (110 males), 84.1% had bilateral limb pain and 31...
September 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28871153/omni-resonant-optical-micro-cavity
#19
Soroush Shabahang, H Esat Kondakci, Massimo L Villinger, Joshua D Perlstein, Ahmed El Halawany, Ayman F Abouraddy
Optical cavities transmit light only at discrete resonant frequencies, which are well-separated in micro-structures. Despite attempts at the construction of planar 'white-light cavities', the benefits accrued upon optically interacting with a cavity - such as resonant field buildup - have remained confined to narrow linewidths. Here, we demonstrate achromatic optical transmission through a planar Fabry-Pérot micro-cavity via angularly multiplexed phase-matching that exploits a bio-inspired grating configuration...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869510/a-hot-polymer-fiber-fabry-perot-interferometer-anemometer-for-sensing-airflow
#20
Cheng-Ling Lee, Kai-Wen Liu, Shi-Hong Luo, Meng-Shan Wu, Chao-Tsung Ma
This work proposes the first hot-polymer fiber Fabry-Perot interferometer (HPFFPI) anemometer for sensing airflow. The proposed HPFFPI is based on a single-mode fiber (SMF) endface that is attached to a UV-cured polymer to form an ultracompact fiber Fabry-Perot microcavity. The proposed polymer microcavity was heated using a low-cost chip resistor with a controllable dc driving power to achieve a desired polymer's steady-state temperature (T) that exceeds the T of the surrounding environment. The polymer is highly sensitive to variations of T with high repeatability...
September 2, 2017: Sensors
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