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Congenital heart defect research

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https://www.readbyqxmd.com/read/27894567/proportion-of-selected-congenital-heart-defects-attributable-to-recognized-risk-factors
#1
Regina M Simeone, Sarah C Tinker, Suzanne M Gilboa, A J Agopian, Matthew E Oster, Owen J Devine, Margaret A Honein
PURPOSE: To assess the contribution of multiple risk factors for two congenital heart defects-hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (TOF). METHODS: We used data from the National Birth Defects Prevention Study (1997-2011) to estimate average adjusted population attributable fractions for several recognized risk factors, including maternal prepregnancy overweight-obesity, pregestational diabetes, age, and infant sex. RESULTS: There were 594 cases of isolated simple HLHS, 971 cases of isolated simple TOF, and 11,829 controls in the analysis...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27891781/geographic-distribution-of-live-births-with-tetralogy-of-fallot-in-north-carolina-2003-to-2012
#2
Jennifer S Nelson, Rebecca C Stebbins, Paula D Strassle, Robert E Meyer
BACKGROUND: Geographic variation in congenital heart disease is not well-described. This study uses geographic information systems (GIS) to describe the spatial epidemiology of tetralogy of Fallot (TOF), in North Carolina (NC) and to compare travel time for cases to congenital heart centers in NC. METHODS: Using the NC Birth Defects Monitoring Program database, live births with TOF born between 2003 and 2012 were identified. Birth certificates provided demographic variables...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27803055/rebuilding-a-broken-heart-lessons-from-developmental-and-regenerative-biology
#3
REVIEW
Muge N Kuyumcu-Martinez, Michael C Bressan
In May 2016, the annual Weinstein Cardiovascular Development and Regeneration Conference was held in Durham, North Carolina, USA. The meeting assembled leading investigators, junior scientists and trainees from around the world to discuss developmental and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight the depth and range of research currently being performed to uncover the causes of human cardiac diseases and develop potential therapies...
November 1, 2016: Development
https://www.readbyqxmd.com/read/27801971/twenty-five-year-survival-for-aboriginal-and-caucasian-children-with-congenital-heart-defects-in-western-australia-1980-to-2010
#4
Wendy N Nembhard, Jenny Bourke, Helen Leonard, Luke Eckersley, Jingyun Li, Carol Bower
BACKGROUND: Australian Aboriginal children have increased infant and childhood mortality compared with Caucasian children, but their mortality related to congenital heart defects (CHDs) throughout life is unknown. METHODS: We conducted a retrospective cohort study using data on 8,110 live born, singleton infants with CHDs born January 1980 to December 2010 from the Western Australian Register of Developmental Anomalies. Vital status was determined from death and medical records...
November 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27783864/modulation-of-systemic-metabolism-by-mmp-2-from-mmp-2-deficiency-in-mice-to-mmp-2-deficiency-in-patients
#5
Carlos Fernandez-Patron, Zamaneh Kassiri, Dickson Leung
Matrix metalloproteinase-2 (MMP-2) is a 72-kDa zinc- and calcium-dependent endopeptidase with intracellular and extracellular functions ranging from the modulation of extracellular matrix remodeling to cell growth and migration, angiogenesis, inflammation, and metabolism. An upregulation of MMP-2 activity has the potential to deregulate lipid metabolism through the cleavage of numerous metabolic mediators including plasma lipoproteins and cell surface receptors of lipoproteins. Paradoxically, MMP-2 deficiency induces inflammation and deregulates metabolism...
September 15, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27768247/associations-between-maternal-water-consumption-and-birth-defects-in-the-national-birth-defects-prevention-study-2000-2005
#6
Breanna L Alman, Evan Coffman, Anna Maria Siega-Riz, Thomas J Luben
BACKGROUND: Water and water-based beverages constitute a major part of daily fluid intake for pregnant women, yet few epidemiologic studies have investigated the role of water consumption on birth outcomes. METHODS: We used data from the National Birth Defects Prevention Study to conduct a case-control study investigating associations between maternal water consumption during pregnancy and birth defects (BD). We used interview data on water consumption during the first trimester of pregnancy in 14,454 cases (major BDs n ≥ 50) and 5,063 controls...
October 21, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27718306/common-congenital-anomalies-environmental-causes-and-prevention-with-folic-acid-containing-multivitamins
#7
REVIEW
Swapnalee Sarmah, Pooja Muralidharan, James A Marrs
Congenital anomalies, congenital defects, or birth defects are significant causes of death in infants. The most common congenital defects are congenital heart defects (CHDs) and neural tube defects (NTDs). Defects induced by genetic mutations, environmental exposure to toxins, or a combination of these effects can result in congenital malformations, leading to infant death or long-term disabilities. These defects produce significant mortality and morbidity in the affected individuals, and families are affected emotional and financially...
September 2016: Birth Defects Research. Part C, Embryo Today: Reviews
https://www.readbyqxmd.com/read/27717505/emerging-field-of-cardiomics-high-throughput-investigations-into-transcriptional-regulation-of-cardiovascular-development-and-disease
#8
Christopher E Slagle, Frank L Conlon
Congenital heart defects remain a leading cause of infant mortality in the western world, despite decades of research focusing on cardiovascular development and disease. With the recent emergence of several high-throughput technologies including RNA sequencing, chromatin-immunoprecipitation-coupled sequencing, mass-spectrometry-based proteomics analyses, and the numerous variations of these strategies, investigations into cardiac development have been transformed from candidate-based studies into whole-genome, -transcriptome, and -proteome undertakings...
November 2016: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/27704687/diprosopus-systematic-review-and-report-of-two-cases
#9
María Paz Bidondo, Boris Groisman, Agostina Tardivo, Fabián Tomasoni, Verónica Tejeiro, Inés Camacho, Mariana Vilas, Rosa Liascovich, Pablo Barbero
BACKGROUND: Diprosopus is a subtype of symmetric conjoined twins with one head, facial duplication and a single trunk. Diprosopus is a very rare congenital anomaly. METHODS: This is a systematic review of published cases and the presentation of two new cases born in Argentina. We estimated the prevalence of conjoined twins and diprosopus using data from the National Network of Congenital Anomalies of Argentina (RENAC). RESULTS: The prevalence of conjoined twins in RENAC was 19 per 1,000,000 births (95% confidence interval, 12-29)...
October 5, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27696921/prenatal-identification-of-chd-murmur-using-four-segment-phonocardiographic-signal-analysis
#10
Jitendra Chourasia, Vijay Chourasia, A K Mittra
Congenital heart defects (CHD) are one of the utmost birth defects present in the neonatal after birth and a big challenge for the researchers to identify the structural abnormality during the antepartum period. An algorithm is presented here to identify the presence of CHD through foetal phonocardiographic (fPCG) signals. The recorded fPCG is decomposed using Daubechies4 wavelet with sub-level threshold to remove the noise in the signal. The Shannon energy is used to identify the different peaks of signals and then S1 and S2 according to the intervals between adjacent peaks...
February 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27632192/kincor-a%C3%A2-national-registry-for-paediatric-patients-with-congenital-and-other-types-of-heart-disease-in-the-netherlands-aims-design-and-interim-results
#11
L M Silva, I M Kuipers, F van den Heuvel, R Mendes, R M F Berger, I M van Beynum, L Rozendaal, L A J Rammeloo, G G van Iperen, M Schokking, S Frerich, N A Blom, J M P J Breur, W A Helbing
OBJECTIVE: Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with heart diseases. This paper presents the aims, design and interim results of the KinCor project. METHODS: All children presenting at a Dutch university medical centre with a diagnosis of heart disease from 2012 onwards were eligible for registration in the KinCor database...
November 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27605952/a-systematic-review-of-trends-and-patterns-of-congenital-heart-disease-in-children-in-nigeria-from-1964-2015
#12
Mohammed Abdulkadir, Zainab Abdulkadir
BACKGROUND: Congenital heart diseases cause significant childhood morbidity and mortality. Several restricted studies have been conducted on the epidemiology in Nigeria. No truly nationwide data on patterns of congenital heart disease exists. OBJECTIVES: To determine the patterns of congenital heart disease in children in Nigeria and examine trends in the occurrence of individual defects across 5 decades. METHOD: We searched PubMed database, Google scholar, TRIP database, World Health Organisation libraries and reference lists of selected articles for studies on patterns of congenital heart disease among children in Nigeria between 1964 and 2015...
June 2016: African Health Sciences
https://www.readbyqxmd.com/read/27603536/screening-for-critical-congenital-heart-defects-with-pulse-oximetry-medical-aspects
#13
Andrew K Ewer
The detection of newborn babies with potentially life-threatening, critical congenital heart defects (CCHDs) before they collapse or expire remains an important clinical challenge. The absence of physical signs and the difficulty assessing mild cyanosis means that the newborn baby check misses up to a third of babies. Fetal anomaly ultrasound scanning identifies an increasing proportion, but this screen is operator-dependent and therefore highly variable; although some units report very high detection rates, overall most babies with CCHD are still missed...
September 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27581652/neurodevelopmental-functioning-in-children-being-evaluated-for-heart-transplant-prior-to-2-years-of-age
#14
Tanya N Antonini, William J Dreyer, Susan E Caudle
Cardiac defects represent the most common type of birth defect and children with these abnormalities are known to experience a variety of developmental and neuropsychological delays. Children receiving heart transplants may be at the highest risk for delays as they tend to represent the most severely ill patients with heart disease. This study investigates neurocognitive and adaptive functioning in 20 children under 2 years of age who were undergoing evaluation for heart transplant, comparing their performance to that of normative samples...
August 31, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27569369/a-step-wise-approach-for-analysis-of-the-mouse-embryonic-heart-using-17-6tesla-mri
#15
Rinat Gabbay-Benziv, E Albert Reece, Fang Wang, Amnon Bar-Shir, Chris Harman, Ozhan M Turan, Peixin Yang, Sifa Turan
BACKGROUND: The mouse embryo is ideal for studying human cardiac development. However, laboratory discoveries do not easily translate into clinical findings partially because of histological diagnostic techniques that induce artifacts and lack standardization. AIM: To present a step-wise approach using 17.6T MRI, for evaluation of mice embryonic heart and accurate identification of congenital heart defects. SUBJECTS: 17.5-embryonic days embryos from low-risk (non-diabetic) and high-risk (diabetic) model dams...
August 26, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27541719/cardiac-embryology-and-molecular-mechanisms-of-congenital-heart-disease-a-primer-for-anesthesiologists
#16
Benjamin Kloesel, James A DiNardo, Simon C Body
Congenital heart disease is diagnosed in 0.4% to 5% of live births and presents unique challenges to the pediatric anesthesiologist. Furthermore, advances in surgical management have led to improved survival of those patients, and many adult anesthesiologists now frequently take care of adolescents and adults who have previously undergone surgery to correct or palliate congenital heart lesions. Knowledge of abnormal heart development on the molecular and genetic level extends and improves the anesthesiologist's understanding of congenital heart disease...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27535157/in-ovo-toxico-teratological-effects-of-aluminum-on-embryonic-chick-heart-and-vascularization
#17
Reda H ElMazoudy, Gamal A Bekhet
In spite of extensive research and persistent arguments, the mechanism of aluminum (Al) toxicity is still obscure. It is firmly established that aluminum is a potent neurotoxicant. So, the aim based on is aluminum damage chicken heart, as well as the vitelline circulation. In the first 3 days of incubation (D0-D2), 1.0, 2.0, or 4.0 mg aluminum chloride/0.3 ml avian saline was injected into the center of each viable fertilized egg yolk (AL1, AL2, and AL3 groups, respectively). Control eggs were either uninjected (AL0) or injected (ALS, 0...
August 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27503203/zebrafish-models-of-cardiovascular-disease
#18
Despina Bournele, Dimitris Beis
Cardiovascular disease (CVD) is one of the leading causes of death worldwide. The most significant risk factors associated with the development of heart diseases include genetic and environmental factors such as hypertension, high blood cholesterol levels, diabetes, smoking, and obesity. Coronary artery disease accounts for the highest percentage of CVD deaths and stroke, cardiomyopathies, congenital heart diseases, heart valve defects and arrhythmias follow. The causes, prevention, and treatment of all forms of cardiovascular disease remain active fields of biomedical research, with hundreds of scientific studies published on a weekly basis...
November 2016: Heart Failure Reviews
https://www.readbyqxmd.com/read/27436252/-review-of-epidemiological-studies-on-individual-and-environmental-risk-factors-in-the-aetiology-of-congenital-heart-defects
#19
Silvia Baldacci, Francesca Gorini, Fabrizio Minichilli, Anna Pierini, Michele Santoro, Fabrizio Bianchi
INTRODUCTION: among all congenital malformations, congenital heart defects (CHDs) are the main cause of neonatal mortality and infant mortality and morbidity, thus representing a major public health burden. Several epidemiological studies suggested the role of environmental factors in the genesis of CHDs. OBJECTIVES: to collect the recently literature (2011-2015) on the increasing risk of CHDs in the offspring of exposure to industries, mines, landfills, and incinerators and individual risk factors (cigarette smoking, alcohol use, occupational exposure, socioeconomic status, and air pollution)...
March 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27384265/in-utero-exposure-to-venlafaxine-a-serotonin-norepinephrine-reuptake-inhibitor-increases-cardiac-anomalies-and-alters-placental-and-heart-serotonin-signaling-in-the-rat
#20
Laetitia Laurent, Chunwei Huang, Sheila R Ernest, Anick Berard, Cathy Vaillancourt, Barbara F Hales
BACKGROUND: Human studies are inconsistent with respect to an association between treatment with selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRI/SNRIs) and an increase in the incidence of congenital heart defects. Here we tested the hypothesis that in utero exposure to venlafaxine, a highly prescribed SNRI, increases the incidence of fetal heart defects and alters placental and fetal heart serotonin signaling in the rat. METHODS: Timed-pregnant Sprague Dawley rats were gavaged daily with venlafaxine hydrochloride (0, 3, 10, 30, or 100 mg/kg/day) from gestation day 8 to 20...
July 7, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
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