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Barbara Hanratty, Daniel Stow, Danni Collingridge Moore, Nicole K Valtorta, Fiona Matthews
Background: loneliness has an adverse effect on health and well-being, and is common at older ages. Evidence that it is a risk factor for care home admission is sparse. Objective: to investigate the association between loneliness and care home admission. Setting: English Longitudinal Study of Ageing (ELSA). Participants: two-hundred fifty-four individuals across seven waves (2002-15) of ELSA who moved into care homes were age, sex matched to four randomly selected individuals who remained in the community...
July 10, 2018: Age and Ageing
Marcos M Siliézar, Catuxa Celerio Muñoz, Jon Danel Solano-Iturri, Laura Ortega-Comunian, Manuela Mollejo, Santiago Montes-Moreno, Miguel A Piris
Objectives: Spontaneous rupture of the spleen is occasionally seen as the presenting event in infectious mononucleosis (IM). Diagnosis of these cases can be very challenging. Methods: We describe the morphologic and immunohistochemical findings in a series of seven splenectomy specimens removed after spontaneous rupture in patients with IM. Most cases were submitted for a second opinion since the histology of the cases suggested malignant lymphoma. Results: All the cases showed similar findings, with red pulp expansion occupied by activated T and B cells, including scattered large lymphocytes with both T- and B-cell markers, together with a polymorphic background rich in cytotoxic T cells...
July 10, 2018: American Journal of Clinical Pathology
A Campabadal, B Segura, H C Baggio, A Abos, C Uribe, A I Garcia-Diaz, M J Marti, F Valldeoriola, Y Compta, N Bargallo, C Junque
Objective: The University of Pennsylvania Smell Identification Test (UPSIT) is the most commonly used test to detect olfactory impairment in Parkinson's disease (PD), but the cut-off score for clinical purposes is often difficult to establish because of age and sex effects. The current work aims to study the sensitivity and specificity of the UPSIT Spanish version and its accuracy in discriminating PD patients at different age groups from healthy controls (HC), and to perform an item analysis...
July 11, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
C Cuman, C E Beyer, D Brodie, T Fullston, J I Lin, E Willats, D Zander-Fox, J Mullen
STUDY QUESTION: Is next generation sequencing (NGS) capable of detecting smaller sub-chromosomal rearrangements in human embryos than the manufacturer's quoted resolution suggests? SUMMARY ANSWER: NGS was able to detect unbalanced chromosome segments smaller than the manufacturer's resolution. WHAT IS KNOWN ALREADY: Array Comparative Genomic Hybridization (array-CGH) has been the gold standard platform used for PGD of chromosome rearrangements...
July 10, 2018: Human Reproduction
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Keven Ang, Wern Ee Tang, Chee Fang Sum, Subramaniam Tavintharan, Su Chi Lim
Background: The progression trajectory of renal filtration function has not been well characterized in patients with early-onset type 2 diabetes mellitus (T2DM) although albuminuria is often reported in this population. We aim to study the risk of progressive chronic kidney disease (CKD) in individuals with early-onset T2DM. Methods: In total, 1189 T2DM participants were followed for 3.9 (interquartile range 3.2-4.7) years. Progressive CKD was defined as estimated glomerular filtration rate (eGFR) decline of ≥5 mL/min/1...
July 10, 2018: Nephrology, Dialysis, Transplantation
Pantelis A Sarafidis, Francesca Mallamaci, Charalampos Loutradis, Robert Ekart, Claudia Torino, Antonios Karpetas, Vasileios Raptis, Athanasios Bikos, Aikaterini Papagianni, Olga Balafa, Konstantinos Siamopoulos, Giovanni Pisani, Massimo Morosetti, Antonio Del Giudice, Fillipo Aucella, Luca Di Lullo, Rocco Tripepi, Giovanni Tripepi, Kitty Jager, Friedo Dekker, Gerard London, Carmine Zoccali
Background: Population-specific consensus documents recommend that the diagnosis of hypertension in haemodialysis patients be based on 48-h ambulatory blood pressure (ABP) monitoring. However, until now there is just one study in the USA on the prevalence of hypertension in haemodialysis patients by 44-h recordings. Since there is a knowledge gap on the problem in European countries, we reassessed the problem in the European Cardiovascular and Renal Medicine working group Registry of the European Renal Association-European Dialysis and Transplant Association...
July 10, 2018: Nephrology, Dialysis, Transplantation
S Damanti, C Abbate, I Chiodini, M Cesari, T Nestola, G Belloni, C Mandelli, D Mari, T Lucchi
An 81-year-old woman was hospitalised for behavioural disorders that had been progressively emerging over a period of few weeks. The symptoms appeared to worsen over time. A diagnosis of vascular dementia, complicated by psychosis, was initially hypothesised. The inefficacy of the antipsychotic/benzodiazepine medications used, along with the presence of hypertension, hypokalaemia and metabolic alkalosis (resistant to pharmacological attempts of correction), as well as the hirsutism and the development of several infections, led us to consider Cushing's syndrome...
July 10, 2018: Age and Ageing
Linda J Titus, Lisa M Reisch, Anna N A Tosteson, Heidi D Nelson, Paul D Frederick, Patricia A Carney, Raymond L Barnhill, David E Elder, Martin A Weinstock, Michael W Piepkorn, Joann G Elmore
Objectives: The impact of malpractice concerns on pathologists' use of defensive medicine and interpretations of melanocytic skin lesions (MSLs) is unknown. Methods: A total of 207 pathologists interpreting MSLs responded to a survey about past involvement in malpractice litigation, influence of malpractice concerns on diagnosis, and use of assurance behaviors (defensive medicine) to alleviate malpractice concerns. Assurance behaviors included requesting second opinions, additional slides, additional sampling, and ordering specialized tests...
July 10, 2018: American Journal of Clinical Pathology
Matteo Lambertini, Valeria Fontana, Claudia Massarotti, Francesca Poggio, Chiara Dellepiane, Giuseppina Iacono, Annalisa Abate, Loredana Miglietta, Chiara Ferreccio, Maria Carolina Pescio, Benedetta Conte, Eva Blondeaux, Claudia Bighin, Alessia D'Alonzo, Marina Vaglica, Elisa Zanardi, Francesco Boccardo, Alberto Ballestrero, Paola Anserini, Lucia Del Mastro
BACKGROUND: Despite the availability of different strategies for ovarian function and/or fertility preservation in young breast cancer patients candidates for chemotherapy, limited data are available on patients' actual need of these options. PATIENTS AND METHODS: The PREFER study is a prospective cohort study including premenopausal women with newly diagnosed early stage breast cancer between the age of 18 and 45 years and candidates for chemotherapy. The study aimed to investigate patients' preferences and their choices of the different available strategies for ovarian function and/or fertility preservation (i...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
Esther Gil-Barrionuevo, José Maria Balibrea, Enric Caubet, Oscar Gonzalez, Ramón Vilallonga, José Manuel Fort, Andrea Ciudin, Manel Armengol
INTRODUCTION: Pheochromocytomas are infrequent tumors arised from the chromaphine cells of the adrenal sympathetic system. The excess of circulating catecholamines may lead to different cardiovascular disorders from silent alterations of the myocardial conduction to different forms of cardiomyopathy. The onset as cardiogenic shock is exceptional. PRESENTATION OF CASE: A 35-year-old male, with a known history of acute myopericarditis of unknown origin which debuted as acute pulmonary edema, was admitted with dyspnea in the context of a new heart failure episode with pulmonary edema...
June 27, 2018: International Journal of Surgery Case Reports
Sylvia Annabel Dass, Mohd Nor Norazmi, Armando Acosta Dominguez, Maria Elena Sarmiento Garcia San Miguel, Gee Jun Tye
The discovery of heat shock protein 16 kDa antigen protein has deepen the understanding of latent tuberculosis since it was found to be primarily expressed by Mycobacterium tuberculosis during latent phase leading to the rapid optimization and development in terms of diagnosis and therapeutics. Recently, T cell receptor-like antibody has been explored extensively targeting various diseases due to its dual functionality (T cell receptor and antibody). In this study, a TCR-like domain antibody (A2/Ab) with the binding capacity to Mtb heat shock protein (HSP) 16 kDa antigen presented by major histocompatible complex (MHC) HLA-A*02 was successfully generated via biopanning against human domain antibody library...
July 4, 2018: Molecular Immunology
Sophie Sixou, Katharina Müller, Stéphan Jalaguier, Christina Kuhn, Nadia Harbeck, Doris Mayr, Jutta Engel, Udo Jeschke, Nina Ditsch, Vincent Cavaillès
New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen receptors, strongly interact in BC cells. Although their role in cancer progression has been outlined in the last few years, their function in BC has not been elucidated yet. In this study, we investigated RIP140 and LCoR localization (cytoplasm vs nucleus) in BC samples from a well-characterized cohort of patients (n = 320)...
July 11, 2018: Translational Oncology
Erik Landfeldt, Anna Castelo-Branco, Axel Svedbom, Emil Löfroth, Andrius Kavaliunas, Jan Hillert
BACKGROUND: Several studies have investigated the impact of multiple sclerosis (MS) on the risk of divorce. However, current evidence is inconclusive and limited by e.g. small sample populations, short follow-up, and/or lack of a control group. The objective of this retrospective, observational study was to estimate the long-term impact of MS on the risk of divorce. METHODS: Swedish patients diagnosed with MS between 1975 and 2012 were identified in a nationwide disease-specific register (the Swedish Multiple Sclerosis Registry) and matched with general population controls based on age, sex, region of residency, and marital status...
July 3, 2018: Multiple Sclerosis and related Disorders
Nicholas J Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterberg
There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology...
June 20, 2018: Neurobiology of Aging
Boaz Avidor, Daniel Chemtob, Dan Turner, Irene Zeldis, Shirley Girshengorn, Natalia Matus, Svetlana Achsanov, Simona Gielman, Inbal Schweizer, Lilya Baskin, Licita Schreiber, Zipi Kra-Oz
BACKGROUND: Fourth-generation immunoassays used for HIV screening, simultaneously detect anti-HIV antibodies and HIV-1 P24 antigen, but are prone to false-positive results. Usually, they are followed by highly specific third-generation assay, able to differentiate between HIV-1/2 infections. In Israel, screening algorithm is based on consecutive testing by two fourth-generation assays and confirmation by a third-generation test. OBJECTIVES: To evaluate the performance of this algorithm...
July 9, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Maurice Chan, Seok Hwee Koo, Boran Jiang, Pei Qi Lim, Thean Yen Tan
BACKGROUND: Respiratory infections are common reasons for hospital admission, and are associated with enormous economic burden due to significant morbidity and mortality. The wide spectrum of microbial agents underlying the pathology renders the diagnosis of respiratory infections challenging. Molecular diagnostics offer an advantage to the current serological and culture-based methods in terms of sensitivity, coverage, hands-on time, and time to results. OBJECTIVES: This study aimed to compare the clinical performance of three commercial kits for respiratory viral detection...
July 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Vittorio Pengo, Gentian Denas
Antiphospholipid Syndrome (APS) is a condition characterized by the occurrence of thromboembolic events and/or pregnancy loss combined with one laboratory criterion among Lupus Anticoagulant- LAC, anticardiolipin -aCL, and anti β2-Glycoprotein I -aβ2GPI antibodies. Several hypotheses were put forward to explain the causal role of antibodies in the clinical events but none is fully convincing. Current laboratory diagnosis is based on three tests (LAC, IgG/IgM aβ2GPI and IgG/IgM aCL antibodies). The triple-positive profile (all the three tests positive, same isotype) is associated with a higher risk for thrombosis...
July 7, 2018: Thrombosis Research
Prerna Guleria, Saumya Ranjan Mallick, Prashant Ramteke, Deepali Jain
Anaplastic Lymphoma Kinase positive Large B-cell Lymphoma (ALK+LBCL), is a rare entity, of which case reports exist in literature. It is a B-cell neoplasm with plasma-cell differentiation and displays plasmablasts/immunoblast like cells along with a peculiar immuno-histochemical profile. The cytomorphological characteristics of this entity have been described earlier, however, with the help of this case which had misleading clinical presentation, we wish to highlight certain cytological features which will act as diagnostic clues in identification of cases of ALK+LBCL in aspiration cytology...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Prasath Sathiah, Priyadarshini Dehuri, Debasis Gochhait
A 32 year old male patient presented at the fine needle aspiration (FNA) clinic with slow progressive swellings on bilateral Achilles tendon (Figure: 1 Left larger than right) for more than 3 years. The clinical diagnosis was bilateral giant cell tumor of tendon sheath. The patient also carried an MRI report (performed elsewhere- T2 weighted image) which highlighted the soft tissue lesions in the bilateral tendon with speckled hyperintensity and focal thickening (Figure II). This article is protected by copyright...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Konstantinos Kosmas, Georgia Mitropoulou, Ioannis Provatas, Marios Stamoulas, Anna Marouga
OBJECTIVE: The aims of this study were to determine the expression of PTEN in endometrial adenocarcinomas (as a potential prognostic indicator before treatment) in imprint smears and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. METHODS: One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
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