keyword
MENU ▼
Read by QxMD icon Read
search

Human embryo implantation

keyword
https://www.readbyqxmd.com/read/29908376/the-increased-level-of-tspan5-in-villi-suggests-more-proliferation-and-invasiveness-of-trophoblasts-in-tubal-pregnancy
#1
Tianyang Gao, Yingqiu Liang, Haiyu Tang, Li Quan
OBJECTIVE: This study was to determinate the expression of Tspan5 in tubal ectopic implantation sites and to explore the correlation of the expressive level of Tspan5 at maternal-fetal interface and the occurrence of tubal ectopic pregnancy. STUDY DESIGN: This is a retrospective study. Trophoblastic and endometrial tissues were collected from tubal ectopic pregnancy(Total of 40), and intrauterine pregnancy(Total of 41), who had voluntary abortion, non-pregnancy women(Total of 12), who recieved an diagnostic uterine curettage before IVF-ET for male infertility...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29893478/remodelling-of-human-bone-on-the-chorioallantoic-membrane-cam-of-the-chicken-egg-de-novo-bone-formation-and-resorption
#2
Inés Moreno-Jiménez, Stuart A Lanham, Janos M Kanczler, Gry Hulsart-Billstrom, Nicholas D Evans, Richard O C Oreffo
Traditionally used as an angiogenic assay, the chorioallantoic membrane (CAM) assay of the chick embryo offers significant potential as an in vivo model for xenograft organ-culture. Viable human bone can be cultivated on the CAM and increases in bone volume are evident, however, it remains unclear by what mechanism this change occurs and whether this reflects the physiological process of bone remodelling. In this study we tested the hypothesis that CAM-induced bone remodelling is a consequence of host and graft mediated processes...
June 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29884767/microrna-21-in-extracellular-vesicles-contributes-to-the-growth-of-fertilized-eggs-and-embryo-development-in-mice
#3
Chao Lv, Wen-Xian Yu, Yan Wang, Da-Jing Yi, Ming-Hua Zeng, Hong-Mei Xiao
Human preimplantation embryo development is susceptible to high rates of early embryo wastage. We determined the microRNA-21 (miR-21) expression of extracellular vesicles (EVs) in fertilized eggs and embryo of varying stages and their response to miR-21 microinjection. Sexually mature female and male mice were mated. Next, the expression and immunohistochemistry intensity of surface markers (CD9 and CD63) of EVs were detected in pregnant and non-pregnant mice. Exosomes were co-cultured with embryos for detection of blastocyst formation rate, and embryo apoptosis...
June 8, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29884303/cdk1-inhibition-facilitates-formation-of-syncytiotrophoblasts-and-expression-of-human-chorionic-gonadotropin
#4
Rahim Ullah, Saira Dar, Tanvir Ahmad, Christelle de Renty, Mohammad Usman, Melvin L DePamphilis, Amir Faisal, Syed Shahzad-Ul-Hussan, Zakir Ullah
AIMS: The human placental syncytiotrophoblast (STB) cells play essential roles in embryo implantation and nutrient exchange between the mother and the fetus. STBs are polyploid which are formed by fusion of diploid cytotrophoblast (CTB) cells. Abnormality in STBs formation can result in pregnancy-related disorders. While a number of genes have been associated with CTB fusion the initial events that trigger cell fusion are not well understood. Primary objective of this study was to enhance our understanding about the molecular mechanism of placental cell fusion...
June 2018: Placenta
https://www.readbyqxmd.com/read/29882361/influence-of-human-sperm-origin-testicular-or-ejaculated-on-embryo-morphokinetic-development
#5
Filomena Scarselli, Valentina Casciani, Elisabetta Cursio, Saverio Muzzì, Alessandro Colasante, Simona Gatti, Maria Chiara Greco, Pierfrancesco Greco, Maria Giulia Minasi, Ermanno Greco
In this retrospective observational study (October 2014 - July 2016), the impact of sperm origin on embryo morphokinetics and on clinical outcomes after intracytoplasmic sperm injection was evaluated. The developmental kinetics of embryos obtained either with testicular sperm (40 cycles; testicular sperm group) or with thawed donor sperm (26 cycles; donor sperm group) was analysed up to day-3 of culture with a time-lapse incubation system. In the testicular sperm group, all patients were affected by nonobstructive azoospermia...
June 8, 2018: Andrologia
https://www.readbyqxmd.com/read/29873314/human-sperm-testicular-angiotensin-converting-enzyme-helps-determine-human-embryo-quality
#6
Marta Gianzo, Itziar Urizar-Arenaza, Iraia Muñoa-Hoyos, Zaloa Larreategui, Nicolás Garrido, Luis Casis, Jon Irazusta, Nerea Subirán
Angiotensin-converting enzyme functions in the male reproductive system, but the extent of its function in reproduction is not fully understood. The primary objective of this work was to investigate the relationship between the testicular isoform of angiotensin-converting enzyme present in human spermatozoa and semen parameters, human embryo quality, and assisted reproduction success. A total of 81 semen samples and 635 embryos from couples undergoing oocyte donation cycles at the IVI Bilbao Clinic were analyzed...
June 5, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29866181/expected-advances-in-human-fertility-treatments-and-their-likely-translational-consequences
#7
REVIEW
Norbert Gleicher
BACKGROUND: Due to rapid research progress in reproductive biology and reproductive clinical endocrinology, many human infertility treatments are close to potential breakthroughs and translational applications. We here review current barriers, where such breakthroughs will likely come from, what they will entail, and their potential clinical applications. MAIN TEXT: The radical nature of change will primarily benefit older women, reduce fertility treatment costs and thereby expand access to treatment...
June 4, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29846695/heterogeneous-nuclear-ribonucleoprotein-c1-may-control-mir-30d-levels-in-endometrial-exosomes-affecting-early-embryo-implantation
#8
N Balaguer, I Moreno, M Herrero, M González, C Simón, F Vilella
STUDY QUESTION: Is there a specific mechanism to load the microRNA, hsa-miR-30d, into exosomes to facilitate maternal communication with pre-implantation embryos? SUMMARY ANSWER: The heterogeneous nuclear ribonucleoprotein C1 (hnRNPC1) is involved in the internalization of endometrial miR-30d into exosomes to prepare for its subsequent incorporation into trophectoderm cells. WHAT IS KNOWN ALREADY: Our group previously described a novel cell-to-cell communication mechanism involving the delivery of endometrial microRNAs (miRNAs) from the maternal endometrium to the trophectoderm cells of preimplantation embryos...
May 29, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29846687/expression-of-adhesion-and-extracellular-matrix-genes-in-human-blastocysts-upon-attachment-in-a-2d-co-culture-system
#9
A Aberkane, W Essahib, C Spits, C De Paepe, K Sermon, T Adriaenssens, S Mackens, H Tournaye, J J Brosens, Velde H Van de
STUDY QUESTION: What are the changes in human embryos, in terms of morphology and gene expression, upon attachment to endometrial epithelial cells? SUMMARY ANSWER: Apposition and adhesion of human blastocysts to endometrial epithelial cells are predominantly initiated at the embryonic pole and these steps are associated with changes in expression of adhesion and extracellular matrix (ECM) genes in the embryo. WHAT IS KNOWN ALREADY: Both human and murine embryos have been co-cultured with Ishikawa cells, although embryonic gene expression associated with attachment has not yet been investigated in an in-vitro implantation model...
May 26, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29846546/bone-morphogenetic-protein-2-promotes-human-trophoblast-cell-invasion-by-inducing-activin-a-production
#10
Hong-Jin Zhao, Hsun-Ming Chang, Hua Zhu, Christian Klausen, Yan Li, Peter C K Leung
Bone morphogenetic protein 2 (BMP2) and activin A belong to the transforming growth factor-β (TGF-β) superfamily and are highly expressed in human endometrium and placenta. Studies have demonstrated that activin A and BMP2 play essential roles in the process of early embryo implantation by promoting human trophoblast cell invasion. However, whether activin A production can be regulated by BMP2 in human trophoblast cells remains unknown. The aim of our study was to determine the effects of BMP2 on activin A production and its role in human trophoblast invasion...
May 25, 2018: Endocrinology
https://www.readbyqxmd.com/read/29845791/morphological-ultrastructural-and-molecular-aspects-of-in-vitro-mouse-embryo-implantation-on-human-endometrial-mesenchymal-stromal-cells-in-the-presence-of-steroid-hormones-as-an-implantation-model
#11
Marzieh Rahimipour, Mojdeh Salehnia, Mina Jafarabadi
Objective: This experimental study aimed to evaluate the effects of 17β-estradiol (E2) and progesterone (P4) on the interaction between mouse embryo and human endometrial mesenchymal stromal cells, and gene expressions related to implantation [αV and β3 integrins, interleukin-1 receptor (IL-1R), and leukemia inhibitory factor receptor (LIFR)] using an in vitro twodimensional model. Materials and Methods: In this experimental study, the endometrial stromal cells were isolated enzymatically and mechanically, and cultured to the fourth passage...
October 2018: Cell Journal
https://www.readbyqxmd.com/read/29788175/prevalence-of-xxy-karyotypes-in-human-blastocysts-multicentre-data-from-7549-trophectoderm-biopsies-obtained-during-preimplantation-genetic-testing-cycles-in-ivf
#12
Rossella Mazzilli, Danilo Cimadomo, Laura Rienzi, Antonio Capalbo, Paolo Emanuele Levi Setti, Claudia Livi, Damiano Vizziello, Carlo Foresta, Alberto Ferlin, Filippo Maria Ubaldi
STUDY QUESTION: Which is the prevalence of a 47,XXY karyotype in human blastocysts biopsied during preimplantation genetic testing for aneuploidies (PGT-A) cycles? SUMMARY ANSWER: The prevalence of a 47,XXY karyotype amongst male blastocysts without autosomal aneuploides is ~1%. WHAT IS KNOWN ALREADY: The prevalence of Klinefelter syndrome is estimated as 0.1-0.2% in male newborns. However, the KS phenotype is extremely variable and there are men with a 47,XXY karyotype and less evident signs, who may go undetected...
May 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29773831/dnajc17-is-localized-in-nuclear-speckles-and-interacts-with-splicing-machinery-components
#13
A Pascarella, G Ferrandino, S C Credendino, C Moccia, F D'Angelo, B Miranda, C D'Ambrosio, P Bielli, O Spadaro, M Ceccarelli, A Scaloni, C Sette, M De Felice, G De Vita, E Amendola
DNAJC17 is a heat shock protein (HSP40) family member, identified in mouse as susceptibility gene for congenital hypothyroidism. DNAJC17 knockout mouse embryos die prior to implantation. In humans, germline homozygous mutations in DNAJC17 have been found in syndromic retinal dystrophy patients, while heterozygous mutations represent candidate pathogenic events for myeloproliferative disorders. Despite widespread expression and involvement in human diseases, DNAJC17 function is still poorly understood. Herein, we have investigated its function through high-throughput transcriptomic and proteomic approaches...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773310/maternal-concentrations-of-human-chorionic-gonadotrophin-in-very-early-ivf-pregnancies-and-duration-of-pregnancy-a-follow-up-study
#14
Tom G Tanbo, Manuela Zucknick, Anne Eskild
RESEARCH QUESTION: Are maternal concentrations of human chorionic gonadotropin (HCG) on a fixed day after embryo transfer associated with duration of pregnancy? DESIGN: A follow-up study of 1917 singleton pregnancies after IVF was performed. Embryos were cultured for 2 days and maternal HCG concentration quantified on day 12 after embryo transfer. Duration of pregnancy was obtained from the Medical Birth Registry of Norway. Association of HCG concentration (log2-transformed) with duration of pregnancy was estimated as hazard ratios (HR) with 95% confidence intervals (CI) by applying Cox regression proportional hazard models, where time to delivery for pregnancies shortened because of planned Caesarean delivery or induction of labour was treated as censored...
May 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29757275/isolation-of-primary-human-decidual-cells-from-the-fetal-membranes-of-term-placentae
#15
Tali Farine, Michael Parsons, Stephen Lye, Oksana Shynlova
The decidua, also known as the pregnant endometrium, is a critically important reproductive tissue. Decidual cells, comprised mainly of decidualized stromal cells and immune cells, are responsible for the secretion of hormonal and inflammatory factors which are critical for successful blastocyst implantation, placental development and play a role in the initiation of labor at term and preterm. Many pregnancy complications can arise from perturbations of a fine balance of different cell populations comprising decidua...
April 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29755412/association-between-progesterone-elevation-on-the-day-of-human-chronic-gonadotropin-trigger-and-pregnancy-outcomes-after-fresh-embryo-transfer-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycles
#16
REVIEW
Sandro C Esteves, Gautam Khastgir, Jatin Shah, Kshitiz Murdia, Shweta Mittal Gupta, Durga G Rao, Soumyaroop Dash, Kundan Ingale, Milind Patil, Kunji Moideen, Priti Thakor, Pavitra Dewda
Progesterone elevation (PE) during the late follicular phase of controlled ovarian stimulation in fresh embryo transfer in vitro fertilization (IVF)/intracytoplasmic sperm injection cycles has been claimed to be associated with decreased pregnancy rates. However, the evidence is not unequivocal, and clinicians still have questions about the clinical validity of measuring P levels during the follicular phase of stimulated cycles. We reviewed the existing literature aimed at answering four relevant clinical questions, namely (i) Is gonadotropin type associated with PE during the follicular phase of stimulated cycles? (ii) Is PE on the day of human chorionic gonadotropin (hCG) associated with negative fresh embryo transfer IVF/intracytoplasmic sperm injection (ICSI) cycles outcomes in all patient subgroups? (iii) Which P thresholds are best to identify patients at risk of implantation failure due to PE in a fresh embryo transfer? and (iv) Should a freeze all policy be adopted in all the cycles with PE on the day of hCG? The existing evidence indicates that late follicular phase progesterone rise in gonadotropin releasing analog cycles is mainly caused by the supraphysiological stimulation of granulosa cells with exogenous follicle-stimulating hormone...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29734084/association-between-early-%C3%AE-hcg-kinetics-blastocyst-morphology-and-pregnancy-outcome-in-a-single-blastocyst-transfer-program
#17
Jean-Maxime Girard, Mathilde Simorre, Florence Leperlier, Arnaud Reignier, Tiphaine Lefebvre, Paul Barrière, Thomas Fréour
OBJECTIVE(S): Beta human chorionic gonadotrophin (β-hCG) is secreted by placenta and detectable in maternal serum a few days after embryo implantation. The evolution of β-hCG serum levels is commonly used to confirm early pregnancy and differentiate normal pregnancies from others, either in spontaneous pregnancies or after IVF. However, little is known on the eventual link between blastocyst quality in IVF, pregnancy outcome, and βhCG kinetics. The objective was to evaluate the association between early βhCG rise, blastocyst morphology and pregnancy evolution in a single-blastocyst transfer program STUDY DESIGN: This retrospective cohort study was conducted in a University-affiliated IVF center in 441 couples undergoing 455 single blastocyst transfer cycles leading to a positive pregnancy test 12 days afterwards...
April 30, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29727537/-testicular-histology-does-not-affect-the-clinical-outcomes-of-icsi-in-men-with-non-obstructive-azoospermia
#18
Yan-Rong Kuai, Zhan-Ju He, Sheng Wang, Kai Zhang, Cheng Zeng, Liang Chen, Qing Xue, Jing Shang, Hui-Xia Yang, Yang Xu
Objective: To investigate whether testicular histology influences the clinical outcomes of intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 73 cases of NOA undergoing ICSI, including 105 ICSI cycles and 79 embryo transfer cycles. The infertility of the patients was attributed to male factors only or both male and female tube factors and the females' age was ≤38 years...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29726999/insulin-regulates-glycogen-synthesis-in-human-endometrial-glands-through-increased-gys2
#19
Clare A Flannery, Gina H Choe, Andrew G Fleming, Katherine M Cooke, Caitlin C Radford, Pinar H Kodaman, Michael J Jurczak, Richard G Kibbey, Hugh S Taylor
Context: Glycogen synthesis is a critical metabolic function of the endometrium to prepare for successful implantation and sustain embryo development. Yet regulation of endometrial carbohydrate metabolism is poorly characterized. While glycogen synthesis is attributed to progesterone, we previously found that the metabolic B isoform of insulin receptor is maximally expressed in secretory phase endometrium indicating a potential role of insulin in glucose metabolism. Objective: We sought to determine whether insulin or progesterone regulates glycogen synthesis in human endometrium...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29723118/protective-effects-of-interferon-tau-against-lipopolysaccharide-induced-embryo-implantation-failure-in-pregnant-mice
#20
Kangfeng Jiang, Jing Yang, Yu Chen, Shuai Guo, Gan Zhao, Haichong Wu, Ganzhen Deng
Interferon-tau (IFN-τ), a novel type I interferon, is produced by trophoblast cells in ruminants. Previous studies have confirmed that IFN-τ could induce immunological tolerance in humans and other species. However, there are few reports on whether IFN-τ has a protective effect on embryo implantation failure caused by excessive inflammation at the maternal-fetal interface. In our study, a mouse model of lipopolysaccharide (LPS)-induced implantation failure was successfully established, and we investigated the protective effects of IFN-τ...
May 3, 2018: Journal of Interferon & Cytokine Research
keyword
keyword
55597
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"