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Human embryo implantation

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https://www.readbyqxmd.com/read/29471449/obesity-associated-advanced-glycation-end-products-within-the-human-uterine-cavity-adversely-impact-endometrial-function-and-embryo-implantation-competence
#1
Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29460293/effect-of-the-sexual-abstinence-period-recommended-by-the-world-health-organization-on-clinical-outcomes-of-fresh-embryo-transfer-cycles-with-normal-ovarian-response-after-intracytoplasmic-sperm-injection
#2
J W Lee, J H Cha, S H Shin, H J Cha, J H Kim, C K Park, K A Pak, J S Yoon, S Y Park
This study was to investigate whether the sexual abstinence period (SAP) recommended by the World Health Organization (WHO) affects clinical outcomes. We compared the rate of clinical outcomes between 2-7 and ≥8 days of SAP in first fresh embryo transfer after intracytoplasmic sperm injection (ICSI) in groups of young maternal age (YMA: <38 years) and old maternal age (OMA: ≥38 years). We conducted a retrospective study of 449 first ICSI cycles with a normal ovarian response. SAP was identified before collecting the semen samples...
February 20, 2018: Andrologia
https://www.readbyqxmd.com/read/29456564/role-of-granulocyte-colony-stimulating-factor-in-human-reproduction
#3
REVIEW
Maryam Eftekhar, Elham Naghshineh, Parisa Khani
As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29452422/asynchronous-and-pathological-windows-of-implantation-two-causes-of-recurrent-implantation-failure
#4
P Sebastian-Leon, N Garrido, J Remohí, A Pellicer, P Diaz-Gimeno
STUDY QUESTION: Is endometrial recurrent implantation failure (RIF) only a matter of an asynchronous (displaced) window of implantation (WOI), or could it also be a pathological (disrupted) WOI? SUMMARY ANSWER: Our predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient. WHAT IS KNOWN ALREADY: Since 2002, many gene expression signatures associated with endometrial receptivity and RIF have been described...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29448847/effect-of-early-cumulus-cells-removal-and-early-rescue-icsi-on-pregnancy-outcomes-in-high-risk-patients-of-fertilization-failure
#5
Yuxia He, Haiying Liu, Haiyan Zheng, Li Li, Xin Fu, Jianqiao Liu
OBJECTIVE: The objective of this retrospective study was to evaluate clinical outcomes of early cumulus cells removal and early rescue intracytoplasmic sperm injection (ICSI) in high-risk patients of fertilization failure during human in vitro fertilization (IVF). METHODS: A total of 5,518 patients were enrolled between January 2014 to December 2016. Of which 505 couples performed short insemination with >30% fertilization rate were included in short-term IVF group, 102 patients detected total fertilization failure (TFF) were treated with early rescue ICSI (R-ICSI group), and 4911 couples underwent conventional IVF with overnight co-incubation of gametes (traditional IVF group)...
February 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29439094/uterine-and-placental-distribution-of-selected-extracellular-matrix-ecm-components-in-the-dog
#6
Felix R Graubner, Alois Boos, Selim Aslan, Ibrahim Kücükaslan, Mariusz P Kowalewski
For many years, modifications of the uterine extracellular matrix (ECM) during gestation have not been considered as critical for successful canine (Canis lupus familiaris) pregnancy. However previous reports indicated an effect of free-floating blastocysts on the composition of the uterine ECM. Here, the expression of selected genes involved in structural functions, cell-to-cell communication and inhibition of matrix metalloproteinases were targeted utilizing qPCR and immunohistochemistry. We found that canine free-floating embryos affect gene expression of FN1, ECM1 and TIMP4...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#7
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29430156/effect-of-endometrial-cavity-fluid-on-pregnancy-rate-of-fresh-versus-frozen-in-vitro-fertilization-cycle
#8
Nitika Gupta, Shilpa Bhandari, Pallavi Agrawal, Ishita Ganguly, Aparna Singh
Objective: This study aims to study the difference in etiology and outcome in terms of implantation rate and abortion rate in fresh (self-stimulated) versus frozen (oocyte donation cycle) in vitro fertilization (IVF) and in transient versus persistent fluid. Material and Methods: This retrospective study was conducted in the Department of Reproductive Medicine of tertiary care center from January 2012 to November 2015. Data were collected retrospectively from the departmental files...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29416020/bone-morphogenetic-protein-2-promotes-human-trophoblast-cell-invasion-by-upregulating-n-cadherin-via-non-canonical-smad2-3-signaling
#9
Hong-Jin Zhao, Christian Klausen, Yan Li, Hua Zhu, Yan-Ling Wang, Peter C K Leung
BMP2 expression is spatiotemporally correlated with embryo implantation and is crucial for endometrial decidualization and fertility in mice. BMP2 has been reported to increase the mesenchymal adhesion molecule N-cadherin and enhance cell invasion in cancer cells; moreover, studies suggest that N-cadherin promotes placental trophoblast invasion. However, whether BMP2 can promote trophoblast cell invasion during placentation remains unknown. The objective of our study was to investigate the effects of BMP2 on human trophoblast cell invasion and the involvement of N-cadherin and SMAD signaling...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29415736/uterine-foxl2-regulates-the-adherence-of-the-trophectoderm-cells-to-the-endometrial-epithelium
#10
Michal Elbaz, Ron Hadas, Louise M Bilezikjian, Eran Gershon
BACKGROUND: Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy. In this study, we aimed at evaluating the expression and function of FOXL2 in embryo implantation. METHODS: Mouse uteri at different days of pregnancy were isolated and analyzed for the expression and localization of FOXL2...
February 7, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29408391/single-injection-ex-ovo-transplantation-method-for-broad-spinal-cord-engraftment-of-human-pluripotent-stem-cell-derived-motor-neurons
#11
Maria C Estevez-Silva, Akshitha Sreeram, Stephanie Cuskey, Nikolai Fedorchak, Nisha Iyer, Randolph S Ashton
BACKGROUND: Transplantation of human pluripotent stem cell (hPSC)-derived neurons into chick embryos is an established preliminary assay to evaluate engraftment potential. Yet, with recent advances in deriving diverse human neuronal subtypes, optimizing and standardizing such transplantation methodology for specific subtypes at their correlated anatomical sites is still required. NEW METHOD: We determined the optimal stage of hPSC-derived motor neuron (hMN) differentiation for ex ovo transplantation, and developed a single injection protocol that implants hMNs throughout the spinal cord enabling broad regional engraftment possibilities...
February 3, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29402920/parental-age-and-gene-expression-profiles-in-individual-human-blastocysts
#12
Kiyotaka Kawai, Tatsuya Harada, Tomonori Ishikawa, Rikikazu Sugiyama, Toshihiro Kawamura, Atsumi Yoshida, Osamu Tsutsumi, Fumitoshi Ishino, Toshiro Kubota, Takashi Kohda
The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the influence of parental age on gene expression in the embryo in terms of transgenerational epigenetics to improve the techniques currently used in assisted reproductive medicine. Here, we performed single-embryo RNA-seq analysis on human blastocysts fertilized by intracytoplasmic sperm injection, including from relatively elderly mothers, to elucidate the effects of parental age on the embryonic gene expression profile...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402916/transcriptomic-changes-in-the-pre-implantation-uterus-highlight-histotrophic-nutrition-of-the-developing-marsupial-embryo
#13
Camilla M Whittington, Denis O'Meally, Melanie K Laird, Katherine Belov, Michael B Thompson, Bronwyn M McAllan
Early pregnancy is a critical time for successful reproduction; up to half of human pregnancies fail before the development of the definitive chorioallantoic placenta. Unlike the situation in eutherian mammals, marsupial pregnancy is characterised by a long pre-implantation period prior to the development of the short-lived placenta, making them ideal models for study of the uterine environment promoting embryonic survival pre-implantation. Here we present a transcriptomic study of pre-implantation marsupial pregnancy, and identify differentially expressed genes in the Sminthopsis crassicaudata uterus involved in metabolism and biosynthesis, transport, immunity, tissue remodelling, and uterine receptivity...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29396049/increased-expression-of-angiogenic-cytokines-in-cd56-uterine-natural-killer-cells-from-women-with-recurrent-miscarriage
#14
Xiaoyan Chen, Yingyu Liu, Wing Ching Cheung, Yiwei Zhao, Jin Huang, Jacqueline Pui Wah Chung, Chi Chiu Wang, Tin Chiu Li
OBJECTIVE: To compare the expression pattern of angiogenic cytokines in CD56+ uNK cells from peri-implantation endometrium in women with a history of recurrent miscarriage and fertile controls. METHODS: 28 women were recruited, from which 18 women were diagnosed as recurrent miscarriage and 10 women were of proven fertility. Endometrial biopsy samples were obtained precisely 7 days after luteinization hormone surge in a natural cycle. The angiogenic profile of isolated CD56+ uNK cells was determined by RayBio human angiogenesis antibody array G Series 1000...
January 30, 2018: Cytokine
https://www.readbyqxmd.com/read/29391166/a-speculative-outlook-on-embryonic-aneuploidy-can-molecular-pathways-be-involved
#15
REVIEW
Olga Tšuiko, Tatjana Jatsenko, Lalit Kumar Parameswaran Grace, Ants Kurg, Joris Robert Vermeesch, Fredrik Lanner, Signe Altmäe, Andres Salumets
The journey of embryonic development starts at oocyte fertilization, which triggers a complex cascade of events and cellular pathways that guide early embryogenesis. Recent technological advances have greatly expanded our knowledge of cleavage-stage embryo development, which is characterized by an increased rate of whole-chromosome losses and gains, mixoploidy, and atypical cleavage morphokinetics. Embryonic aneuploidy significantly contributes to implantation failure, spontaneous miscarriage, stillbirth or congenital birth defects in both natural and assisted human reproduction...
January 31, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29370409/does-the-endometrial-gene-expression-of-fertile-women-vary-within-and-between-cycles
#16
Gloria E Evans, Gregory T M Phillipson, Peter H Sykes, Les A McNoe, Cristin G Print, John J Evans
STUDY QUESTION: Does gene expression of putative endometrial implantation markers vary in expression between menstrual cycles? SUMMARY ANSWER: In fertile women the expression of certain genes exhibits a pattern of stable regulation.which is not affected even when sampled twice in one cycle. WHAT IS KNOWN ALREADY: Successful implantation occurs in a minority of IVF embryo transfers. In contrast to knowledge regarding the ovulatory process, there is a sparse understanding of endometrial genes critical to implantation...
January 23, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29365049/reproductive-failure-in-mice-expressing-transgenic-follicle-stimulating-hormone-is-not-caused-by-loss-of-oocyte-quality
#17
Dannielle H Upton, Kirsty A Walters, Kirsten J McTavish, Janet Holt, David J Handelsman, Charles M Allan
Human female reproductive aging features declining ovarian follicle reserve and oocyte quality, and rising levels of circulating follicle stimulating hormone (FSH). We determined the effects of elevated FSH on oocyte-embryo development in mature mice exhibiting premature infertility caused by progressively rising transgenic human FSH (TgFSH) levels. Oocyte-embryo developmental competence and quality were examined using oocyte maturation and aneuploidy rates, biomarkers of oocyte quality, and reciprocal embryo transfers assessed for implantation and pregnancy...
January 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29365037/an-update-on-the-progress-of-transcriptomic-profiles-of-human-endometrial-receptivity
#18
Xi Wang, Qi Yu
Despite advances in our understanding of fertility, implantation failure remains a significant problem for both spontaneous and assisted pregnancies. Most research efforts concerning the process of implantation are embryo-centric, with a dearth of studies on endometrial factors. Currently, there are no practical and effective diagnostic tools available to precisely predict endometrial receptivity. Transcriptomics, a field based on microarray technology, has a number of procedures for clinical applications, although the functional relevance of most identified genes remains unclear...
January 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29357026/effect-of-mouse-ovarian-tissue-cryopreservation-by-vitrification-with-rapid-i-closed-system
#19
Naoki Okamoto, Mariko Nakajima, Yodo Sugishita, Nao Suzuki
PURPOSE: Currently, open systems are mainly used for cryopreservation of ovarian tissue, oocytes, and embryos, but there is a potential risk of contamination. This study was performed to assess ovarian tissue cryopreservation by a closed vitrification system (Rapid-i vitrification system™), which is already used clinically for oocyte/embryo cryopreservation. METHODS: Ovaries of C57BL/6J mice were frozen and thawed by using the Rapid-i vitrification system™ (Rapid-i) followed by implantation into recipient mice...
January 22, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29353513/effects-of-different-open-cryo-carriers-on-embryo-survival-and-clinical-outcome-in-frozen-embryo-transfer-cycle-patients
#20
Dapeng Chu, Lei Fu, Wenhui Zhou, Yuan Li
The purpose of this study was to compare the efficacy of different open cryo-carriers: the CryoloopTM, CryotopTM, and CryoleafTM, in embryo survival and clinical outcome in patients with frozen embryo transfer (FET) cycle. We analyzed the embryo survival rate and clinical outcome in 325 patients of 348 FET cycles vitrified with the CryoloopTM (160 cycles), CryotopTM (105 cycles), or CryoleafTM (83 cycles). No significant differences were observed in embryo survival rate (98.8% vs. 100% vs. 97.7%, p > 0...
January 20, 2018: Systems Biology in Reproductive Medicine
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