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https://www.readbyqxmd.com/read/29036479/a-structural-basis-for-the-antibiotic-resistance-conferred-by-an-n1-methylation-of-a1408-in-16s-rrna
#1
Hiroki Kanazawa, Fumika Baba, Mai Koganei, Jiro Kondo
The aminoglycoside resistance conferred by an N1-methylation of A1408 in 16S rRNA by a novel plasmid-mediated methyltransferase NpmA can be a future health threat. In the present study, we have determined crystal structures of the bacterial ribosomal decoding A site with an A1408m1A antibiotic-resistance mutation both in the presence and absence of aminoglycosides. G418 and paromomycin both possessing a 6'-OH group specifically bind to the mutant A site and disturb its function as a molecular switch in the decoding process...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29035009/prevalence-antibiotic-resistance-and-mlst-typing-of-helicobacter-pylori-in-algiers-algeria
#2
Naïma Raaf, Wahiba Amhis, Houria Saoula, Ahmed Abid, Mhamed Nakmouche, Abdelmalek Balamane, Nassima Ali Arous, Mounira Ouar-Korichi, Filipa F Vale, Lucie Bénéjat, Francis Mégraud
BACKGROUND: Helicobacter pylori infection is common in Algeria, but there are few data on the characterization of isolated strains. The aim of this study was to update data on the prevalence of H. pylori in patients submitted to endoscopy, antibiotic resistance, and phylogeography of H. pylori strains isolated in Algiers. MATERIALS AND METHODS: This is a prospective study carried out between November 2015 and August 2016. The culture of H. pylori was performed on antral and fundic gastric biopsies of adult patients from 3 hospitals...
October 16, 2017: Helicobacter
https://www.readbyqxmd.com/read/29034855/bradyrhizobium-namibiense-sp-nov-a-symbiotic-nitrogen-fixing-bacterium-from-root-nodules-of-lablab-purpureus-hyacinth-bean-in-namibia
#3
Jann Lasse Grönemeyer, Wiebke Bünger, Barbara Reinhold-Hurek
Four strains of symbiotic bacteria from root nodules of hyacinth bean (Lablab purpureus (L.) Sweet) from Namibia were previously identified as a novel group within the genus Bradyrhizobium. To confirm their taxonomic status, these strains were further characterized by taking a polyphasic approach. The type strain possessed 16S rRNA gene sequences identical to Bradyrhizobium paxllaeri LMTR 21(T) and Bradyrhizobiumicense LMTR 13(T), the full-length sequences were identical to those retrieved from SAMN05230119 and SAMN05230120, respectively...
October 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29034850/pseudomonas-aeruginosa-variants-obtained-from-veterinary-clinical-samples-reveal-a-role-for-cyclic-di-gmp-in-biofilm-formation-and-colony-morphology
#4
Maria T Brock, Galya C Fedderly, Grace I Borlee, Michael M Russell, Liliana K Filipowska, Doreene R Hyatt, Ryan A Ferris, Bradley R Borlee
Overuse of antibiotics is contributing to an emerging antimicrobial resistance crisis. To better understand how bacteria adapt tolerance and resist antibiotic treatment, Pseudomonas aeruginosa isolates obtained from infection sites sampled from companion animals were collected and evaluated for phenotypic differences. Selected pairs of clonal isolates were obtained from individual infection samples and were assessed for antibiotic susceptibility, cyclic di-GMP levels, biofilm production, motility and genetic-relatedness...
October 16, 2017: Microbiology
https://www.readbyqxmd.com/read/29034431/cultivation-dependent-and-high-throughput-sequencing-approaches-studying-the-co-occurrence-of-antibiotic-resistance-genes-in-municipal-sewage-system
#5
An-Dong Li, Liping Ma, Xiao-Tao Jiang, Tong Zhang
During the past years, antibiotic-resistant bacteria (ARB) leading for the spreading of antibiotic resistance genes (ARGs) became a global problem, especially multidrug-resistant (MDR) bacteria are considered the prime culprit of antibiotic resistance. However, the correlation between the antibiotic-resistant phenotype and the ARG profiles remains poorly understood. In the present study, metagenomic functional screening and metagenomic analysis of coliforms were combined to explore the phenotype and genotype of the ARBs from municipal sewage...
October 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29034106/epidemiology-and-antibiotic-resistance-phenotypes-of-diarrheagenic-escherichia-coli-responsible-for-infantile-gastroenteritis-in-ouagadougou-burkina-faso
#6
Ali Konaté, René Dembélé, Nathalie K Guessennd, Fernique Konan Kouadio, Innocent Kouamé Kouadio, Mohamed Baguy Ouattara, Wendpoulomdé A D Kaboré, Assèta Kagambèga, Haoua Cissé, Hadiza Bawa Ibrahim, Touwendsida Serge Bagré, Alfred S Traoré, Nicolas Barro
The emergence and persistence of multidrug-resistant (MDR) diarrheagenic Escherichia coli (DEC) causing acute diarrhea is a major public health challenge in developing countries. The aim of this study was to evaluate the resistance phenotypes of DEC isolated from stool samples collected from children less than 5 years of age with acute diarrhea living in Ouagadougou/Burkina Faso. From August 2013 to October 2015, this study was carried out on 31 DEC strains of our study conducted in "Centre Médical avec Antenne Chirurgicale (CMA)" Paul VI and CMA of Schiphra...
September 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/29034091/phenotypic-and-genotypic-characterization-of-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus-isolated-from-hospital-food
#7
Farhad Safarpoor Dehkordi, Hasan Gandomi, Afshin Akhondzadeh Basti, Ali Misaghi, Ebrahim Rahimi
BACKGROUND: Pathogenic biotypes of the Methicillin-resistant Staphylococcus aureus (MRSA) strains are considered to be one of the major cause of food-borne diseases in hospitals. The present investigation was done to study the pattern of antibiotic resistance and prevalence of antibiotic resistance genes of different biotypes of the MRSA strains isolated from various types of hospital food samples. METHODS: Four-hundred and eighty-five raw and cooked hospital food samples were cultured and MRSA strains were identified using the oxacillin and cefoxitin disk diffusion tests and mecA-based PCR amplification...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29033338/antibiotic-resistance-genes-in-waste-water
#8
REVIEW
Antti Karkman, Thi Thuy Do, Fiona Walsh, Marko P J Virta
Waste water and waste water treatment plants can act as reservoirs and environmental suppliers of antibiotic resistance. They have also been proposed to be hotspots for horizontal gene transfer, enabling the spread of antibiotic resistance genes between different bacterial species. Waste water contains antibiotics, disinfectants, and metals which can form a selection pressure for antibiotic resistance, even in low concentrations. Our knowledge of antibiotic resistance in waste water has increased tremendously in the past few years with advances in the molecular methods available...
October 12, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29033302/the-antimicrobial-susceptibility-of-helicobacter-pylori-in-strains-isolated-from-children-in-israel
#9
Nina Pastukh, Avi Peretz, Diana Brodsky, Natlya Isakovich, Maya Azrad, Avi On
BACKGROUND: Helicobacter pylori is a pathogen that causes inflammation in the gastric mucosa, and may lead to a peptic ulcer, perforation, or malignancy. Children are at risk of contracting H. pylori and developing subsequent morbidity. In children, diagnosis and management are difficult and merit a different approach than with adults. OBJECTIVE: To describe resistance rates of H. pylori to antibiotics such as amoxicillin, tetracycline, clarithromycin, metronidazole, levofloxacin, and Rifampicin...
October 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29032651/complete-genome-sequence-of-salmonella-enterica-subsp-enterica-serovar-typhimurium-st1120-isolated-from-swine-feces-in-korea
#10
Seongok Kim, Eunsuk Kim, Soyeon Park, Tae-Wook Hahn, Hyunjin Yoon
Salmonella enterica subsp. enterica serovar Typhimurium, one of the most common food-borne pathogens, is transmitted mainly through contaminated food derived from infected animals. In this study, S. Typhimurium ST1120, an isolate from pig feces in Korea, was subjected to whole genome analysis to understand its genomic features associated with virulence. The genome of ST1120 was found to have a circular chromosome of 4,855,001 bp (GC content 52.2%) and a plasmid of 6,863 bp (GC content 46.0%). This chromosome was predicted to have 4,558 open reading frames (ORFs), 17 pseudogenes, 22 rRNA genes, and 86 tRNA genes...
October 14, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29031406/prevalence-of-antibiotic-resistance-genes-from-effluent-of-coastal-aquaculture-south-korea
#11
Hyun Min Jang, Young Beom Kim, Sangki Choi, Yunho Lee, Seung Gu Shin, Tatsuya Unno, Young Mo Kim
The wide use of antibiotics in aquaculture for prophylactic and therapeutic purposes can potentially lead to the prevalence of antibiotic resistance genes (ARGs). This study reports for the first time the profile of ARGs from effluents of coastal aquaculture located in South Jeolla province and Jeju Island, South Korea. Using quantitative PCR (qPCR), twenty-two ARGs encoding tetracycline resistance (tetA, tetB, tetD, tetE, tetG, tetH, tetM, tetQ, tetX, tetZ, tetBP), sulfonamide resistance (sul1, sul2), quinolone resistance (qnrD, qnrS, aac(6')-Ib-cr), β-lactams resistance (blaTEM, blaCTX, blaSHV), macrolide resistance (ermC), florfenicol resistance (floR) and multidrug resistance (oqxA) and a class 1 integrons-integrase gene (intI1) were quantified...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29030459/household-triclosan-and-triclocarban-effects-on-the-infant-and-maternal-microbiome
#12
Jessica V Ribado, Catherine Ley, Thomas D Haggerty, Ekaterina Tkachenko, Ami S Bhatt, Julie Parsonnet
In 2016, the US Food and Drug Administration banned the use of specific microbicides in some household and personal wash products due to concerns that these chemicals might induce antibiotic resistance or disrupt human microbial communities. Triclosan and triclocarban (referred to as TCs) are the most common antimicrobials in household and personal care products, but the extent to which TC exposure perturbs microbial communities in humans, particularly during infant development, was unknown. We conducted a randomized intervention of TC-containing household and personal care products during the first year following birth to characterize whether TC exposure from wash products perturbs microbial communities in mothers and their infants...
October 13, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29030440/multiple-roles-of-two-efflux-pumps-in-a-polycyclic-aromatic-hydrocarbon-degrading-pseudomonas-putida-strain-b6-2-dsm-28064
#13
Xuemei Yao, Fei Tao, Kunzhi Zhang, Hongzhi Tang, Ping Xu
Microbial bioremediation is a promising approach for the removal of polycyclic aromatic hydrocarbon (PAH) contaminants. Many degraders of PAHs possess efflux pump genes in their genomes; however, their specific roles in the degradation of PAHs have not been clearly elucidated. In this study, two efflux pumps, TtgABC and SrpABC, were systematically investigated to determine their functions in a PAH-degrading Pseudomonas putida strain B6-2 (DSM 28064). The disruption of genes ttgABC or srpABC resulted in a defect in organic solvent tolerance...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030439/conjugation-mediated-horizontal-gene-transfer-of-clostridium-perfringens-plasmids-in-the-chicken-gastrointestinal-tract-results-in-the-formation-of-new-virulent-strains
#14
Jake A Lacey, Anthony L Keyburn, Mark E Ford, Ricardo W Portela, Priscilla A Johanesen, Dena Lyras, Robert J Moore
Clostridium perfringens is a gastrointestinal pathogen capable of causing disease in a variety of hosts. Necrotic enteritis in chickens is caused by C. perfringens strains that produce the pore-forming toxin NetB, the major virulence factor for this disease. Like many other C. perfringens toxins and antibiotic resistance genes, NetB is encoded on a conjugative plasmid. Conjugative transfer of the netB-containing plasmid pJIR3535 has been demonstrated in vitro with a netB null mutant. This study has investigated the effect of plasmid transfer on disease pathogenesis, with two genetically distinct transconjugants constructed under in vitro conditions, within the intestinal tract of chickens...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030436/a-mutator-phenotype-promoting-the-emergence-of-spontaneous-oxidative-stress-resistant-mutants-in-campylobacter-jejuni
#15
Lei Dai, Orhan Sahin, Yizhi Tang, Qijing Zhang
Campylobacter jejuni is a leading cause of foodborne illnesses worldwide. As a microaerophilic organism, C. jejuni must be able to defend against oxidative stress encountered both in the host and in the environment. How Campylobacter utilizes a mutation-based mechanism for adaptation to oxidative stress is still unknown. Here we present a previously undescribed phenotypic and genetic mechanism that promotes the emergence of oxidative stress resistant mutants. Specifically, we showed that a naturally occurring mutator phenotype, resulting from a loss of function mutation in the DNA repair enzyme MutY, increased oxidative stress resistance (OX(R)) in C...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29030312/antimicrobial-resistance-of-enterococcus-spp-isolated-from-thai-fermented-pork-in-chiang-rai-province-thailand
#16
Kamonnaree Chotinantakul, Nittaya Chansiw, Seiji Okada
OBJECTIVES: The aim of this study is to evaluate the prevalence of resistant phenotypes and genes of Enterococcus spp. to explore the range of resistant profiles from Thai traditional fermented pork. METHODS: A total of 120 Thai fermented pork specimens in Chiang Rai, Thailand were collected and antimicrobial resistance was identified using 11 antimicrobial agents in enterococcal isolates, via an agar disk diffusion method. The antibiotic resistant genes from resistant phenotypes and virulence genes were observed...
October 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29030266/plasmid-mediated-doxycycline-resistance-in-a-yersinia-pestis-strain-isolated-from-a-rat
#17
Nicolas Cabanel, Christiane Bouchier, Minoarisoa Rajerison, Elisabeth Carniel
Emergence of antibiotic-resistant Y. pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar were previously identified and characterized. Both strains carried conjugative plasmids that conferred resistance to streptomycin or to multiple antibacterial drugs. Here we characterized a novel Y. pestis strain (IP2180H) that exhibited resistance to doxycycline. This strain was isolated from a rat in Antananarivo (Madagascar) in 1998. Resistance was carried by a conjugative plasmid (pIP2180H) homologous to pB71 from Salmonella enterica...
October 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29030239/surgical-antibiotic-prophylaxis-and-risk-for-postoperative-antibiotic-resistant-infections
#18
Margot E Cohen, Hojjat Salmasian, Jianhua Li, Jianfang Liu, Philip Zachariah, Jason D Wright, Daniel E Freedberg
BACKGROUND: Antibiotic-resistant infections have high rates of morbidity and mortality and exposure to antibiotics is the crucial risk factor for development of antibiotic resistance. If surgical antibiotic prophylaxis (SAP) increases risk for antibiotic-resistant infections, prophylaxis may cause net harm even if it decreases overall infection rates. STUDY DESIGN: This retrospective cohort study included adults who underwent elective surgical procedures and developed infections within 30 post-operative days...
August 29, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29030025/emerge-of-blandm-1-and-blaoxa-48-like-harboring-carbapenem-resistant-klebsiella-pneumoniae-isolates-from-hospitalized-patients-in-southwestern-iran
#19
Zahra Hosseinzadeh, Hadi Sedigh Ebrahim-Saraie, Jamal Sarvari, Jalal Mardaneh, Behzad Dehghani, Seyed Mohammad Hossein Rokni-Hosseini, Mohammad Motamedifar
BACKGROUND: One of the most important emerging carbapenem-resistant bacteria is Klebsiella pneumoniae (K. pneumoniae). The present study aimed to investigate the antibiotic susceptibility pattern of K. pneumoniae isolates and detection of carbapenemase producing K. pneumoniae obtained from Iranian hospitalized patients. METHODS: This cross-sectional study was performed on 211 K. pneumoniae isolates which were recovered from different clinical specimens from 2014 to 2015...
October 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29029194/envelope-proteome-changes-driven-by-rama-overproduction-in-klebsiella-pneumoniae-that-enhance-acquired-%C3%AE-lactam-resistance
#20
Juan-Carlos Jiménez-Castellanos, Wan Ahmad Kamil Wan Nur Ismah, Yuiko Takebayashi, Jacqueline Findlay, Thamarai Schneiders, Kate J Heesom, Matthew B Avison
Objectives: In Klebsiella pneumoniae, overproduction of RamA results in reduced envelope permeability and reduced antimicrobial susceptibility but clinically relevant resistance is rarely observed. Here we have tested whether RamA overproduction can enhance acquired β-lactam resistance mechanisms in K. pneumoniae and have defined the envelope protein abundance changes upon RamA overproduction during growth in low and high osmolarity media. Methods: Envelope permeability was estimated using a fluorescent dye accumulation assay...
October 6, 2017: Journal of Antimicrobial Chemotherapy
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