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Surface chemistry

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https://www.readbyqxmd.com/read/28240872/annexin-v-conjugated-mixed-micelles-as-a-potential-drug-delivery-system-for-targeted-thrombolysis
#1
Yang Pan, Xiaoting Ren, Shuang Wang, Xin Li, Xianglin Luo, Zongning Yin
To alleviate the hemorrhagic side effect of thrombolysis therapy, a thrombus targeted drug delivery system based on the specific affinity of Annexin V to phosphatidylserine exposed on the membrane surface of activated platelet was developed. The amphiphilic and biodegradable biomaterial, polycaprolactone-block-poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-hydroxyethyl methacrylate) (PCL-b-PDMAEMA-b-PHEMA (PCDH)) triblock polymer, was synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) to use as the nanocarriers of thrombolytic drug...
February 27, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28240862/engineering-of-surface-chemistry-for-enhanced-sensitivity-in-nanoporous-interferometric-sensing-platforms
#2
Cheryl Suwen Law, Georgina Sylvia, Mahdieh Nemati, Jingxian Yu, Dusan Losic, Andrew D Abell, Abel Santos
In this study, we explore new approaches to engineering the surface chemistry of interferometric sensing platforms based on nanoporous anodic alumina (NAA) and reflectometric interference spectroscopy (RIfS). Two surface engineering strategies are presented, namely; (i) selective chemical functionalization of the inner surface of NAA pores with amine-terminated thiol molecules, and (ii) selective chemical functionalization of the top surface of NAA with dithiol molecules. The strong molecular interaction of Au3+ ions with thiol-containing functional molecules of alkane chain or peptide character provides a model sensing system with which to assess the sensitivity of these NAA platforms by both molecular feature and surface engineering...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28240553/chemical-morphology-of-frozen-mixed-nitrate-salt-solutions
#3
Karen J Morenz, D James Donaldson
Surface chemistry on ice can play an important role in atmospheric composition, but uncertainties about chemical partitioning within ice samples has hindered the development of accurate models of these systems. Using Raman microscopy, we examine the nitrate distribution in ice and liquid samples containing environmentally relevant concentrations of sodium chloride, sodium bromide, and a sea salt analogue "Instant Ocean." Nitrate is enhanced at the surface compared to the bulk in all frozen samples, but to different degrees depending on the added salt...
February 27, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28239700/light-driven-rotary-molecular-motors-without-point-chirality-a-minimal-design
#4
Jun Wang, Baswanth Oruganti, Bo Durbeej
A fundamental requirement for achieving photoinduced unidirectional rotary motion about an olefinic bond in a molecular motor is that the potential energy surface of the excited state is asymmetric with respect to clockwise and counterclockwise rotations. In most available light-driven rotary molecular motors, such asymmetry is guaranteed by the presence of a stereocenter. Here, we present non-adiabatic molecular dynamics simulations based on multiconfigurational quantum chemistry to demonstrate that this chiral feature is not essential for inducing unidirectional rotary motion in molecules that incorporate a cyclohexenylidene moiety into a protonated Schiff-base framework...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28238435/lateral-and-longitudinal-patterns-of-water-physico-chemistry-and-trace-metal-distribution-and-partitioning-in-a-large-river-floodplain
#5
Dorothea Hug Peter, Emmanuel Castella, Vera I Slaveykova
Floodplain water bodies provide habitat to diversified ecological communities. Floodplains are also among the most impacted aquatic ecosystems. While the link between the lateral connectivity of floodplain sites to the main channel and their plant, fish and invertebrate communities has been well established, detailed information on chemical characteristics and particularly on trace metal spatial distribution and partitioning is scarce. The aim of this study was to examine the link between the lateral connectivity and physico-chemical variables, their trace metal concentrations and partitioning as well as the upstream-downstream gradient of these parameters...
February 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28238145/high-accuracy-determination-of-cytotoxic-responses-from-graphene-oxide-exposure-using-imaging-flow-cytometry
#6
Sandra Vranic, Kostas Kostarelos
Graphene and other 2D materials have received increased attention in the biomedical field due to their unique properties and potential use as carriers for targeted drug delivery or in regenerative medicine. Before the exploitation of graphene-based materials in biomedicine becomes a reality, it is necessary to establish the full toxicological profile and better understand how the material interacts with cells and tissues. Because specific properties, such as flake size and surface chemistry, might determine whether graphene can achieve therapeutic efficacy without causing toxicity, it is important to develop highly accurate and reliable screening techniques to accurately assess the biocompatibility of different types of graphene-based materials...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28238127/ligand-exchange-and-1-h-nmr-quantification-of-single-and-mixed-moiety-thiolated-ligand-shells-on-gold-nanoparticles
#7
Ashley M Smith, Jill E Millstone
The use of nanoparticles in biomedicine critically depends on their surface chemistry. For metal nanoparticles, a common way to tune this surface chemistry is through mass action ligand exchange, where ligand exchange can be used to expand the functionality of the resulting nanoparticle conjugates. Specifically, the quantity, identity, and arrangement of the molecules in the resulting ligand shell each can be tuned significantly. Here, we describe methods to exchange and quantify thiolated and non-thiolated ligands on gold nanoparticle surfaces...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237782/in-silico-approach-to-investigating-the-adsorption-mechanisms-of-short-chain-perfluorinated-sulfonic-acids-and-perfluorooctane-sulfonic-acid-on-hydrated-hematite-surface
#8
Hongru Feng, Yuan Lin, Yuzhen Sun, Huiming Cao, Jianjie Fu, Ke Gao, Aiqian Zhang
Short chain perfluorinated sulfonic acids (PFSAs) that were introduced as alternatives for perfluorooctane sulfonic acid (PFOS) have been widely produced and used. However, few studies have investigated the environmental process of short chain PFSAs, and the related adsorption mechanisms still need to be uncovered. The water-oxide interface is one of the major environmental interfaces that plays an important role in affecting the adsorption behaviour and transport potential of the environmental pollutant. In this study, we performed molecular dynamics simulations and quantum chemistry calculations to investigate the adsorption mechanisms of five PFSAs and their adsorption on hydrated hematite surface as well...
February 14, 2017: Water Research
https://www.readbyqxmd.com/read/28235995/hydrazide-functionalized-affinity-on-conventional-support-materials-for-glycopeptide-enrichment
#9
Muhammad Salman Sajid, Fahmida Jabeen, Dilshad Hussain, Muhammad Naeem Ashiq, Muhammad Najam-Ul-Haq
In affinity chromatography, enrichment of biomolecules is dependent on the selection of affinity sites immobilized onto a suitable support material. A few hydrazide - functionalized materials with surface modification protocols compatible to conventional support materials like silica and cellulose are reported. The study demonstrates the modification/derivatization pathways that can be adopted to modify the support materials with similar surface chemistry like cellulose, poly(GMA/DVB), or diamond. Poly(GMA/DVB) and cellulose represent hydrophilic supports whereas diamond is a hydrophobic support material...
February 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28230354/chemical-modification-of-semiconductor-surfaces-for-molecular-electronics
#10
Ayelet Vilan, David Cahen
Inserting molecular monolayers within metal/semiconductor interfaces provides one of the most powerful expressions of how minute chemical modifications can affect electronic devices. This topic also has direct importance for technology as it can help improve the efficiency of a variety of electronic devices such as solar cells, LEDs, sensors, and possible future bioelectronic ones. The review covers the main aspects of using chemistry to control the various aspects of interface electrostatics, such as passivation of interface states and alignment of energy levels by intrinsic molecular polarization, as well as charge rearrangement with the adjacent metal and semiconducting contacts...
February 23, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28230343/interfacial-mechanical-properties-of-graphene-on-self-assembled-monolayers-experiments-and-simulations
#11
Qing Tu, Ho Shin Kim, Thomas J Oweida, Zehra Parlak, Yaroslava G Yingling, Stefan Zauscher
Self-assembled monolayers (SAMs) have been widely used to engineer the electronic properties of substrate-supported graphene devices. However, little is known about how the surface chemistry of SAMs affects the interfacial mechanical properties of graphene supported on SAMs. Fluctuations and changes in these properties affect the stress transfer between substrate and the supported graphene and thus the performance of the graphene-based devices. The changes in interfacial mechanical properties can be characterized by measuring the out-of-plane elastic properties...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229597/molecular-seesaw-intricate-dynamics-and-versatile-chemistry-of-heteroaromatics-on-metal-surfaces
#12
Sergey N Filimonov, Wei Liu, Alexandre Tkatchenko
The design of novel elementary surface processes is important for applications in catalysis, single-molecule junctions, molecular sensors, switches and surface mounted molecular machines. Here we demonstrate by van der Waals inclusive density functional theory calculations that a small and relatively simple heteroaromatic compound s-triazine (C$_3$H$_3$N$_3$) unexpectedly possesses five metastable states when adsorbed on the Pt(111) surface. This diversity of the adsorption states stems from an interplay between versatile molecule/surface chemical bonding and van der Waals interactions and from ``softening'' of the aromatic ring by nitrogen substitution, which makes folding of the aromatic ring energetically much less demanding as compared to benzene...
February 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28229590/impacts-of-crosslinkers-on-biological-effects-of-mesoporous-silica-nanoparticles
#13
Yi-Ping Chen, Si-Han Wu, I-Chih Chen, Chien-Tsu Chen
Chemically synthesized crosslinkers play decisive roles in variable cargos attached to nanoparticles (NPs). Previous studies reported that surface properties, such as the size, charge, and surface chemistry, are particularly important determinants influencing the biological fate and actions of NPs and cells. Recent studies also focused on the relationship of serum proteins with the surface properties of NPs (also called the protein corona), which is recognized as a key factor in determining the cytotoxicity and biodistribution...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229319/a-review-of-the-structure-and-dynamics-of-nanoconfined-water-and-ionic-liquids-via-molecular-dynamics-simulation
#14
REVIEW
Masumeh Foroutan, S Mahmood Fatemi, Farshad Esmaeilian
During the past decade, the research on fluids in nanoconfined geometries has received considerable attention as a consequence of their wide applications in different fields. Several nanoconfined systems such as water and ionic liquids, together with an equally impressive array of nanoconfining media such as carbon nanotube, graphene and graphene oxide have received increasingly growing interest in the past years. Water is the first system that has been reviewed in this article, due to its important role in transport phenomena in environmental sciences...
February 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28226245/subconjunctival-injectable-dendrimer-dexamethasone-gel-for-the-treatment-of-corneal-inflammation
#15
Uri Soiberman, Siva P Kambhampati, Tony Wu, Manoj K Mishra, Yumin Oh, Rishi Sharma, Jiangxia Wang, Abdul Elah Al Towerki, Samuel Yiu, Walter J Stark, Rangaramanujam M Kannan
Corneal inflammation is often encountered as a key pathological event in many corneal diseases. Current treatments involve topical corticosteroids which require frequent instillations due to rapid tear turnover, causing side-effects such as corneal toxicity and elevated intraocular pressure (IOP). Hence, new interventions that can reduce side effects, dosing frequency, and increase patient compliance can be highly beneficial. In this study, we explore a subconjunctival injectable gel based on G4-PAMAM dendrimer and hyaluronic acid, cross-linked using thiol-ene click chemistry, incorporated with dendrimer dexamethasone (D-Dex) conjugates as a potential strategy for sustained delivery and enhanced bioavailability of corticosteroids...
February 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28226220/water-oxidation-mechanisms-of-metal-oxide-catalysts-by-vibrational-spectroscopy-of-transient-intermediates
#16
Miao Zhang, Heinz Frei
Water oxidation is an essential reaction of an artificial photosystem for solar fuel generation because it provides electrons needed to reduce carbon dioxide or protons to a fuel. Earth-abundant metal oxides are among the most attractive catalytic materials for this reaction because of their robustness and scalability, but their efficiency poses a challenge. Knowledge of catalytic surface intermediates gained by vibrational spectroscopy under reaction conditions plays a key role in uncovering kinetic bottlenecks and provides a basis for catalyst design improvements...
February 22, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28225818/heat-induced-radiolabeling-and-click-chemistry-a-powerful-combination-for-generating-multifunctional-nanomaterials
#17
Hushan Yuan, Moses Q Wilks, Georges El Fakhri, Marc D Normandin, Charalambos Kaittanis, Lee Josephson
A key advantage of nanomaterials for biomedical applications is their ability to feature multiple small reporter groups (multimodality), or combinations of reporter groups and therapeutic agents (multifunctionality), while being targeted to cell surface receptors. Here a facile combination of techniques for the syntheses of multimodal, targeted nanoparticles (NPs) is presented, whereby heat-induced-radiolabeling (HIR) labels NPs with radiometals and so-called click chemistry is used to attach bioactive groups to the NP surface...
2017: PloS One
https://www.readbyqxmd.com/read/28222611/influence-of-peg-coating-on-the-oral-bioavailability-of-gold-nanoparticles-in-rats
#18
Ahmed Alalaiwe, Georgia Roberts, Paul Carpinone, John Munson, Stephen Roberts
Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study used the classical method of comparing blood concentration area under the curve (AUC) following intravenous and oral doses to determine the oral bioavailability of 1, 2 and 5 kDa PEG-coated 5 nm gold nanoparticles (AuNPs)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28221385/ir-spectroscopic-investigations-of-chemical-and-photochemical-reactions-on-metal-oxides-bridging-the-materials-gap
#19
REVIEW
Yuemin Wang, Christof Wöll
In this review, we highlight recent progress (2008-2016) in infrared reflection absorption spectroscopy (IRRAS) studies on oxide powders achieved by using different types of metal oxide single crystals as reference systems. Precise polarization- and azimuth-dependent IRRAS data recorded for single crystal substrates has allowed for fundamental insights into the surface chemistry and photochemistry of numerous probe molecules on various surfaces exposed by three very important metal oxides (ZnO, TiO2, and CeO2)...
February 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28221353/from-helical-to-planar-chirality-by-on-surface-chemistry
#20
Oleksandr Stetsovych, Martin Švec, Jaroslav Vacek, Jana Vacek Chocholoušová, Andrej Jančařík, Jiří Rybáček, Krzysztof Kosmider, Irena G Stará, Pavel Jelínek, Ivo Starý
The chirality of molecular structures is paramount in many phenomena, including enantioselective reactions, molecular self-assembly, biological processes and light or electron-spin polarization. Flat prochiral molecules, which are achiral in the gas phase or solution, can exhibit adsorption-induced chirality when deposited on surfaces. The whole array of such molecular adsorbates is naturally racemic as spontaneous global mirror-symmetry breaking is disfavoured. Here we demonstrate a chemical method of obtaining flat prochiral molecules adsorbed on the solid achiral surface in such a way that a specific adsorbate handedness globally dominates...
March 2017: Nature Chemistry
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