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https://www.readbyqxmd.com/read/29226152/the-phytoestrogen-genistein-produces-similar-effects-as-17%C3%AE-estradiol-on-anxiety-like-behavior-in-rats-at-12-weeks-after-ovariectomy
#1
Juan Francisco Rodríguez-Landa, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Eduardo Rivadeneyra-Domínguez, Blandina Bernal-Morales, Emma Virginia Herrera-Huerta, Andrea Santos-Torres
The phytoestrogen genistein produces anxiolytic-like effects in ovariectomized rats, which highlights its potential therapeutic effect in ameliorating anxiety in surgical menopausal women. However, no studies have directly compared the effects of identical doses of genistein and 17β-estradiol, the main estrogen used in hormone replacement therapy in menopausal women. The present study evaluated the anxiolytic-like effects of identical doses of genistein and 17β-estradiol (0.045, 0.09, and 0.18 mg/kg/7 days, s...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225782/update-on-gh-therapy-in-adults
#2
REVIEW
Cesar Luiz Boguszewski
Over the last three decades, short- and long-term observational studies, clinical trials, systematic reviews, and meta-analyses have provided relevant information on the efficacy and safety of growth hormone (GH) replacement therapy in adults with GH deficiency (AGHD). The knowledge acquired during this time has been compiled into different guidelines that offer clinicians an evidence-based, practical approach for the management of AGHD. There are, however, still open questions in some key areas in which recommendations are supported by only moderate or weak evidence...
2017: F1000Research
https://www.readbyqxmd.com/read/29224673/understanding-the-role-of-environmental-factors-in-the-development-of-systemic-lupus-erythematosus
#3
REVIEW
Christine G Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H Costenbader
Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29207728/the-effect-of-soy-isoflavones-on-the-menopause-rating-scale-scoring-in-perimenopausal-and-postmenopausal-women-a-pilot-study
#4
Marya Ahsan, Ayaz Khurram Mallick
Introduction: Menopause is associated with many unpleasant symptoms which vary in different phases of menopausal transition. Although, Hormone Replacement Therapy (HRT) is considered the most effective mode of treatment for these symptoms, its use is associated with increased risk of breast cancer, endometrial cancer and thromboembolic events. Soy isoflavones are being widely used as a safer alternative to HRT, even though scientific evidence of their efficacy is poor or lacking. Aim: To study the effect of soy isoflavone supplementation on the menopausal symptoms in perimenopausal and postmenopausal women...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207221/-therapy-of-glucocorticoid-induced-osteoporosis
#5
REVIEW
Marta Arazzi, Giorgia Di Fulvio, Lorenzo Ottavio Di Pietro, Xhensila Grabocka, Maria Olimpia Longo, Gabriella Micioni, Alessandro Pezzutto, Luca Piscitani, Alessandra Schiazza, Simona Silvestri, Giacinta Vigilante, Luigi Amoroso, Mario Bonomini
Glucocorticoid-induced osteoporosis (GIO) is a major cause of secondary osteoporosis that starts early after the beginning of therapy even for low drug doses. Glucocorticoids are used for the treatment of immunologic nephropathies and in the setting of kidney transplant. In clinical practice, a number of algorithms are available; they allow us to estimate the long-term risk of major osteoporotic fracture; but none of them is specific for GIO. To date, the therapeutic approach comprises both general measures aimed at correcting calcium and vitamin D intake, and drugs (bisphosphonates, teriparatide, hormone replacement therapy, denosumab) that ameliorate bone mineral density and patient outcomes...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29206809/effect-of-recombinant-human-growth-hormone-therapy-on-blood-lipid-and-carotid-intima-media-thickness-in-children-with-growth-hormone-deficiency
#6
Ming Chen, Dongmei Gan, Yili Luo, Sharvan Rampersad, Lu Xu, Shaoling Yang, Nan Li, Hong Li
BACKGROUND: Reports on the association between growth hormone deficiency (GHD) and cardiovascular risk factors in children are limited. We aim to investigate the effect of different doses of rhGH therapy on blood lipid and cIMT in Chinese GHD children. METHODS: Ninety children including 60 isolated GHD children and 30 healthy children were enrolled. GHD children were randomly divided into 2 groups (A and B) according to rhGH dose given: Group A received 0.23 mg/kg/week and group B 0...
December 5, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29204393/lymphocutaneous-sporotrichosis-treated-with-potassium-iodide-with-development-of-subclinical-hypothyroidism-wolff-chaikoff-effect
#7
Pooja Arora, M Raihan, Asha Kubba, Ram K Gautam
Sporotrichosis is a subcutaneous mycotic infection caused by Sporothrix schenckii that is acquired by traumatic implantation. The diagnosis is established by demonstration of fungal elements on histopathology and culture. Potassium iodide, azole antifungals, and terbinafine are the treatment options available. In this article, we report a 60-year-old female with lymphocutaneous sporotrichosis that responded well to potassium iodide. However, subclinical hypothyroidism (Wolff-Chaikoff effect) was encountered as a side effect of therapy which was managed with thyroxine replacement...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29199166/which-drugs-are-risk-factors-for-the-development-of-gastroesophageal-reflux-disease
#8
Zeynel Mungan, Binnur Pınarbaşı Şimşek
Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs. The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility. In this article, we report our investigation of the relationships between GERD and medications within the scope of the "Turkish GERD Consensus Group...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29197845/neck-mass-an-obstructive-cause-of-respiratory-distress-with-medical-management
#9
Vijay Singh, Aakash Pandita, Girish Gupta, Amit Shukla
Congenital goitre is a known cause of hypothyroidism in newborn. Congenital goitre can be due to defective synthesis of thyroxine or administration of antithyroid drugs to the mother during pregnancy. In this case report, we report an instance of a preterm male infant with antenatally detected goitre presenting as a neck mass with congenital hypothyroidism. Hormonal replacement therapy was started immediately after birth which lead to resolution of the mass and normalisation of thyroid function.
December 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29194818/rapid-non-genomic-modulation-by-neurosteroids-of-dendritic-spines-in-the-hippocampus-androgen-estrogen-and-corticosteroid
#10
REVIEW
Gen Murakami, Yasushi Hojo, Asami Kato, Yoshimasa Komatsuzaki, Shigeo Horie, Mika Soma, Jonghyuk Kim, Suguru Kawato
Memories are stored in synapses which consist of axon terminals and dendritic spines. Dendritic spines are postsynaptic structures of synapses and essential for synaptic plasticity and cognition. Therefore, extensive investigations about functions and structures of spines have been performed. Sex steroids and stress steroids have been shown to modulate hippocampal synapses. Although rapid modulatory action of sex steroids on synapses has been studied in hippocampal neurons over several decades, its essential molecular mechanisms have not been fully understood...
December 1, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29194051/blood-tissue-and-imaging-biomarkers-in-calcific-aortic-valve-stenosis-past-present-and-future
#11
Mylène Shen, Lionel Tastet, Jutta Bergler-Klein, Philippe Pibarot, Marie-Annick Clavel
PURPOSE OF REVIEW: Calcific aortic valve stenosis is the most prevalent valvular heart disease in the high-income countries. To this date, no medical therapy has been proven to prevent or to stop the progression of aortic valve stenosis. The physiopathology of aortic valve stenosis is highly complex and involves several signalling pathways, as well as genetic related factors, which delay the elaboration of effective pharmacotherapies. Moreover, it is difficult to predict accurately the progression of the valve stenosis and finding the optimal timing for aortic valve replacement remains challenging...
November 30, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29191934/management-of-endocrine-disease-fertility-pregnancy-and-lactation-in-women-with-adrenal-insufficiency
#12
Gurpreet Anand, Felix Beuschlein
With the introduction of hormonal substitution therapy in the 1950s, adrenal insufficiency has been turned into a manageable disease in pregnant women. In fact, in the light of glucocorticoid replacement therapy and improved obstetric care, it is realistic to expect good maternal and fetal outcome in patients with adrenal insufficiency. However, there are still a number of challenges such as establishing the diagnosis of adrenal insufficiency in pregnant women and optimizing the treatment of adrenal insufficiency and related comorbidities prior as well as during pregnancy...
November 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29188893/therapeutic-role-of-punica-granatum-pomegranate-seed-oil-extract-on-bone-turnover-and-resorption-induced-in-ovariectomized-rats
#13
N Z Shaban, I M Talaat, F H Elrashidy, A Y Hegazy, A S Sultan
CONTEXT: Postmenopausal osteoporosis is mostly caused by increased bone remodeling resulting from estrogen deficiency. Hormone replacement therapy (HRT) is used to prevent osteoporosis, but it increases the risk for breast cancer, thromboembolism, strokes, and heart attacks. Pomegranate seed oil extract (SOE) is rich in phytoestrogen and antioxidant compounds. OBJECTIVES: To evaluate the therapeutic role of SOE against bone turnover, resorption and osteoporosis induced in ovariectomized rats as a postmenopausal model and comparing the results with those from Generic CycloProgynova drug (D)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29184808/recovery-of-steroid-induced-adrenal-insufficiency
#14
REVIEW
Areej K Younes, Noor K Younes
Secondary adrenal insufficiency can result from insufficient stimulation of the adrenal glands due to inadequate secretion or synthesis of adrenocorticotropic hormone (ACTH). This can be caused by hypopituitarism, central nervous system injury (tumors, radiation, and surgery) or long-term glucocorticoid therapy. Glucocorticoids were introduced in the 1950s, and have been used for their anti-inflammatory and other pharmacological effects, and also as replacement therapy for adrenal insufficiency. However, chronic glucocorticoid use may lead to suppression of the hypothalamic pituitary adrenal axis through negative feedback...
October 2017: Translational Pediatrics
https://www.readbyqxmd.com/read/29183775/novel-effects-of-phytoestrogenic-soy-isoflavones-on-serum-calcium-and-chloride-in-premenopausal-women-a-2-year-double-blind-randomized-placebo-controlled-study
#15
Lee-Jane W Lu, Nai-Wei Chen, Fatima Nayeem, V-M Sadagopa Ramanujam, Yong-Fang Kuo, Donald G Brunder, Manubai Nagamani, Karl E Anderson
BACKGROUND: Soy phytoestrogens are potential alternatives to postmenopausal hormone replacement therapy (HRT). Adverse effects of HRT such as myocardial infarction, stroke, and pulmonary embolism are mediated by calcium-induced signaling. OBJECTIVE: To determine whether soy isoflavones affect serum calcium in healthy female subjects. DESIGN: In a double-blind trial, 197 premenopausal women were randomly assigned to either isoflavone (N = 99) or placebo pills (N = 98) 5 days per week for up to 2 years, plus prenatal vitamins...
November 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29181437/clinical-features-of-patients-treated-by-peritoneal-dialysis-for-over-a-decade
#16
Mengli Tong, Yuhui Wang, Jun Ni, Ning Weng, Chuanxia Chen, Hongyu Chen, Lindholm Bengt
BACKGROUND: Peritoneal dialysis (PD) is well-established as renal replacement therapy in end stage renal disease and has survival rates similar or better than hemodialysis (HD) for the initial years on dialysis therapy. However retention rate is lower due to higher technique failure rates than in HD and few patients stay on PD for more than 10 years (PD>10 yrs). Here we investigated clinical features characterizing PD>10 yrs patients. PATIENTS AND METHODS: In a single center study of 450 prevalent PD patients, 35 PD>10 yrs patients (n=35) were compared with patients (n=415) who had been on PD for shorter periods of time in terms of clinical characteristics...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29181135/graves-disease-thyrotoxicosis-and-propylthiouracil-related-agranulocytosis-successfully-treated-with-therapeutic-plasma-exchange-and-g-csf-followed-by-total-thyroidectomy
#17
Anna Candoni, Federico De Marchi, Fabio Vescini, Sara Mauro, Cristina Rinaldi, Marco Piemonte, Nicholas Rabassi, Maria Vittoria Dubbini, Renato Fanin
Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering with Graves' disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter and thyro-gastric syndrome...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29175149/neoadjuvant-trastuzumab-pertuzumab-and-chemotherapy-versus-trastuzumab-emtansine-plus-pertuzumab-in-patients-with-her2-positive-breast-cancer-kristine-a-randomised-open-label-multicentre-phase-3-trial
#18
Sara A Hurvitz, Miguel Martin, W Fraser Symmans, Kyung Hae Jung, Chiun-Sheng Huang, Alastair M Thompson, Nadia Harbeck, Vicente Valero, Daniil Stroyakovskiy, Hans Wildiers, Mario Campone, Jean-François Boileau, Matthias W Beckmann, Karen Afenjar, Rodrigo Fresco, Hans-Joachim Helms, Jin Xu, Yvonne G Lin, Joseph Sparano, Dennis Slamon
BACKGROUND: HER2-targeted treatments have improved outcomes in patients with HER2-positive breast cancer in the neoadjuvant, adjuvant, and metastatic settings; however, some patients remain at risk of relapse or death for many years after treatment of early-stage disease. Therefore, new strategies are needed. We did a phase 3 trial to assess a neoadjuvant regimen for HER2-positive breast cancer that replaces traditional systemic chemotherapy with targeted treatment. METHODS: We did a randomised, open-label phase 3 KRISTINE trial in 68 Translational Research In Oncology centres (hospitals and specialty cancer centres in Asia, Europe, USA, and Canada)...
November 23, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29171625/-the-risks-of-avoiding-hormone-replacement-therapy-during-menopause
#19
Juan Enrique Blümel, Eugenio Arteaga
No abstract text is available yet for this article.
June 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29171476/-recombinant-human-parathyroid-hormone-in-the-therapy-of-hypoparathyroidism
#20
A K Eremkina, N G Mokrysheva, E V Kovaleva, Yu A Krupinova
Hypoparathyroidism is an endocrine disease that results from deficiency or complete absence of parathyroid hormone (PTH), a biologically active 84-amino acid polypeptide. Standard therapy for chronic hypoparathyroidism includes oral calcium salts and active vitamin D metabolites and is aimed at maintaining a balance between optimal near-normal serum calcium concentration and normocalcuria. Traditional treatment regimens not always lead to the compensation for calcium and phosphorus metabolism. Until recently, hypoparathyroidism is the only endocrine disorder that has not been treated with the recombinant hormone...
2017: Terapevticheskiĭ Arkhiv
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