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gastroesophag reflux disease

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https://www.readbyqxmd.com/read/28229067/the-effect-of-world-trade-center-exposure-on-the-timing-of-diagnoses-of-obstructive-airway-disease-chronic-rhinosinusitis-and-gastroesophageal-reflux-disease
#1
Xiaoxue Liu, Jennifer Yip, Rachel Zeig-Owens, Jessica Weakley, Mayris P Webber, Theresa M Schwartz, David J Prezant, Michael D Weiden, Charles B Hall
OBJECTIVES: In a cohort of rescue/recovery workers exposed to the dust that resulted from the collapse of the World Trade Center (WTC), we assessed how a diagnosis of obstructive airways disease (OAD) affected the likelihood of a subsequent diagnosis of chronic rhinosinusitis (CRS) or gastroesophageal reflux disease (GERD). We also assessed whether OAD acted as a mediator of the association between exposure to the WTC rescue/recovery effort and CRS and GERD diagnoses. METHODS: In this prospective cohort study, we analyzed Fire Department of the City of New York physician diagnoses of OAD, CRS, and GERD that were first documented between September 11, 2001, and September 10, 2011, among 8,968 WTC-exposed firefighters...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28225537/laryngeal-sensitivity-testing-in-youth-with-exercise-inducible-laryngeal-obstruction
#2
Irena Hočevar-Boltežar, Uroš Krivec, Maja Šereg-Bahar
Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Laryngeal mucosal alterations were assessed according to the Reflux Finding Score (RFS). The data concerning diseases possibly affecting the upper airway, findings of previously performed flexible videolaryngoscopy during exercise, and RFS score were compared between the participants with laryngeal hyposensitivity and those with normal sensitivity...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28224471/five-year-outcomes-after-vertical-sleeve-gastrectomy-for-severe-obesity-a-prospective-cohort-study
#3
Tone Nygaard Flølo, John R Andersen, Ronette L Kolotkin, Anny Aasprang, Gerd K Natvig, Karl O Hufthammer, Villy Våge
BACKGROUND: We present 5-year outcomes after vertical sleeve gastrectomy (VSG), including complications and revisions, weight change, obesity-related diseases and health-related quality of life (HRQOL). METHODS: Patients operated from December 2005 to November 2010 were included. All variables except HRQOL (obtained using Short Form-36) were assessed prospectively. HRQOL data was assessed cross-sectionally, comparing 5-year results to both a baseline cohort of severely obese patients prior to bariatric surgery and to Norwegian norms...
February 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28223720/is-endoscopic-ultrasound-examination-necessary-in-the-management-of-esophageal-cancer
#4
REVIEW
Tomas DaVee, Jaffer A Ajani, Jeffrey H Lee
Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound (EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223087/do-sleeve-gastrectomy-and-gastric-bypass-influence-treatment-with-proton-pump-inhibitors-4-years-after-surgery-a-nationwide-cohort
#5
Jérémie Thereaux, Thomas Lesuffleur, Sébastien Czernichow, Arnaud Basdevant, Simon Msika, David Nocca, Bertrand Millat, Anne Fagot-Campagna
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common obesity-related co-morbidity that routinely is treated by continuous proton pump inhibitor (PPI) therapy. A number of concerns have been raised regarding the risk of de novo GERD or exacerbation of preexisting GERD after sleeve gastrectomy (SG). OBJECTIVE: To assess PPI use at 4 years after bariatric surgery. SETTING: French National Health Insurance. METHODS: Data were extracted from the French National Health Insurance database...
December 23, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28222168/fewer-acute-respiratory-infection-episodes-among-patients-receiving-treatment-for-gastroesophageal-reflux-disease
#6
Herng-Ching Lin, Sudha Xirasagar, Shiu-Dong Chung, Chung-Chien Huang, Ming-Chieh Tsai, Chao-Hung Chen
Patients with gastroesophageal reflux disease (GERD) present with comorbid complications with implications for healthcare utilization. To date, little is known about the effects of GERD treatment with a proton-pump inhibitor (PPI) on patients' subsequent healthcare utilization for acute respiratory infections (ARIs). This population-based study compared ARI episodes captured through outpatient visits, one year before and one year after GERD patients received PPI treatment. We used retrospective data from the Longitudinal Health Insurance Database 2005 in Taiwan, comparing 21,486 patients diagnosed with GERD from 2010 to 2012 with 21,486 age-sex matched comparison patients without GERD...
2017: PloS One
https://www.readbyqxmd.com/read/28220362/the-role-of-impedance-planimetry-in-the-evaluation-of-esophageal-disorders
#7
REVIEW
Nitin K Ahuja, John O Clarke
PURPOSE OF REVIEW: Impedance planimetry measures tissue wall distensibility as a function of pressure and cross-sectional area. Recent interest in this technique's relevance to the gastrointestinal tract has been accelerated by the availability of the functional lumen imaging probe, a catheter-based system that dynamically quantitates these biomechanical properties. Herein, we review the device's particular utility in the setting of esophageal pathology, including processes affecting the esophageal body as well as the upper and lower esophageal sphincters...
February 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28216140/expression-profiles-of-cancer-stem-cell-markers-cd133-cd44-musashi-1-and-epcam-in-the-cardiac-mucosa-barrett-s-esophagus-early-esophageal-adenocarcinoma-advanced-esophageal-adenocarcinoma-sequence
#8
Anna Mokrowiecka, Lothar Veits, Christina Falkeis, Jacek Musial, Radzislaw Kordek, Mariusz Lochowski, Jozef Kozak, Agnieszka Wierzchniewska-Lawska, Michael Vieth, Ewa Malecka-Panas
INTRODUCTION: Barrett's esophagus (BE), which develops as a result of gastroesophageal reflux disease, is a preneoplastic condition for esophageal adenocarcinoma (EAC). A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet. AIMS: We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression. METHODS: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded blocks from 58 patients with normal cardiac mucosa (n=5), BE (n=14), early EAC (pT1) from mucosal resection (n=17) and advanced EAC (pT1-T4) from postoperative specimens (n=22)...
December 30, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28215067/epidemiology-and-natural-history-of-gastro-esophageal-reflux-disease
#9
Edoardo Savarino, Elisa Marabotto, Giorgia Bodini, Gaia Pellegatta, Claudia Coppo, Elisa Giambruno, Matteo Brunacci, Patrizia Zentilin, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is highly prevalent in Western countries, particularly when considering its most classic symptom, that is heartburn. This symptom is very frequent in the community and ranges from 10% to more than 30%, according to the various population-based studies. This disease is much more represented in Europe and US than in Asiatic countries. It has been shown that GERD prevalence increases in parallel with the remarkable growth of obesity, as this condition is able to favor all the pathogenetic mechanisms leading to it...
February 17, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28213877/improved-control-of-hypertension-following-laparoscopic-fundoplication-for-gastroesophageal-reflux-disease
#10
Zhiwei Hu, Meiping Chen, Jimin Wu, Qing Song, Chao Yan, Xing Du, Zhonggao Wang
This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease (GERD) can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery...
February 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28212976/functional-lumen-imaging-probe-for-the-management-of-esophageal-disorders-expert-review-from-the-clinical-practice-updates-committee-of-the-aga-institute
#11
REVIEW
Ikuo Hirano, John E Pandolfino, Guy E Boeckxstaens
The functional luminal imaging probe is a Food and Drug Administration-approved measurement tool used to measure simultaneous pressure and diameter to guide management of various upper gastrointestinal disorders. Additionally, this tool is also approved to guide therapy during bariatric procedures and specialized esophageal surgery. Although it has been commercially available since 2009 as the endolumenal functional lumen imaging probe (EndoFLIP), the functional luminal imaging probe has had limited penetrance into clinical settings outside of specialized centers...
March 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28210089/prevalence-of-gastroesophageal-reflux-disease-in-a-country-with-a-high-occurrence-of-helicobacter-pylori
#12
Serhat Bor, Gul Kitapcioglu, Elmas Kasap
AIM: To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS: Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. "Frequent symptoms" were defined heartburn and/or regurgitation occurring at least weekly. RESULTS: The prevalence of GERD was 22...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28209602/a-novel-murine-model-of-esophageal-non-erosive-reflux-disease-nerd-from-inflammation-to-impairment-in-mucosal-integrity
#13
Renan O Silva, Francisco Fábio B Oliveira, Rudy D Bingana, Mailton O Arruda, Philip Woodland, Chung Lee, Miguel A Nobre E Souza, Pedro Marcos G Soares, Armenio A Santos, Daniel Sifrim, Marcellus H L P Souza
Non-erosive reflux disease (NERD) is a highly prevalent phenotype of the gastroesophageal reflux disease (GERD). In this study, we developed a novel murine model of NERD in mice with microscopic inflammation and impairment in the epithelial esophageal barrier. Female Swiss mice were subjected to the following surgical procedure: the transitional region between the forestomach and the glandular portion of the stomach was ligated, and a nontoxic ring was placed around the duodenum near the pylorus. The control group underwent sham surgery...
February 16, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28203282/the-role-of-dexlansoprazole-modified-release-in-the-management-of-gastroesophageal-reflux-disease
#14
REVIEW
Ronnie Fass, Rosita Frazier
Dexlansoprazole modified-release (MR) is the R-enantiomer of lansoprazole and is currently the only proton-pump inhibitor (PPI) with a novel dual delayed release (DDR) formulation. Overall, dexlansoprazole MR demonstrates a similar safety and side-effect profile as lansoprazole. Dexlansoprazole MR has been shown to be highly efficacious in healing erosive esophagitis, maintaining healed esophageal mucosa in patients with erosive esophagitis and controlling symptoms of patients with nonerosive reflux disease (NERD)...
February 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28199735/novel-gastric-mucosal-findings-in-association-with-proton-pump-inhibitors
#15
EDITORIAL
Hajime Isomoto, Hiroki Kurumi
Proton pump inhibitors (PPIs) are prescribed worldwide as the treatment of choice for gastroesophageal reflux disease, and are known to exert preventive effects for upper gastrointestinal injuries due to aspirin or non-steroidal anti-inflammatory drugs. On the other hand, the long-term use of PPIs may cause such adverse events as fractures and enteric infections. Recently, they have been associated with mucosal changes including parietal cell protrusions, oxyntic gland dilatations and fundic gland polyps (FGPs)...
February 15, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28197221/factors-leading-to-refractory-asthma-in-patients-from-saudi-arabia
#16
Amal M Al-Moamary, Mohamed S Al-Hajjaj, Mohamed S Al Moamary
AIM: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia. METHODS: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. RESULTS: The mean age was 45...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28192647/a-double-blind-randomized-multicenter-clinical-trial-investigating-the-efficacy-and-safety-of-esomeprazole-single-therapy-versus-mosapride-and-esomeprazole-combined-therapy-in-patients-with-esophageal-reflux-disease
#17
Ju Yup Lee, Sung Kook Kim, Kwang Bum Cho, Kyung Sik Park, Joong Goo Kwon, Jin Tae Jung, Eun Young Kim, Byung Ik Jang, Si Hyung Lee
Background/Aims: We aimed to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rate according to the Los Angeles classification for esomeprazole alone and esomeprazole plus mosapride. Methods: A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at week 4 and 8...
February 13, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28192107/gastrointestinal-complications-of-obesity
#18
Michael Camilleri, Harmeet Malhi, Andres Acosta
Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett's esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28191340/is-metabolic-syndrome-considered-to-be-a-risk-factor-for-gastroesophageal-reflux-disease-non-erosive-or-erosive-esophagitis-a-systematic-review-of-the-evidence
#19
REVIEW
Mohammad Mohammadi, Nahid Ramezani Jolfaie, Rooya Alipour, Mitra Zarrati
CONTEXT: The incidences of both gastroesophageal reflux disease (GERD) and metabolic syndrome (MetS) have increased in recent years, and it has been suggested that there is a probable association between the two. The aim of this review is to clarify whether or not MetS is a risk factor for the incidence of GERD. EVIDENCE AQUISITION: We searched the PubMed, ProQuest, Ovid, Science Direct, and Google Scholar databases up to February 2015 regarding the relationship between GERD and MetS as found in observational studies...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28190989/candidate-serum-metabolite-biomarkers-for-differentiating-gastroesophageal-reflux-disease-barrett-s-esophagus-and-high-grade-dysplasia-esophageal-adenocarcinoma
#20
Matthew F Buas, Haiwei Gu, Danijel Djukovic, Jiangjiang Zhu, Lynn Onstad, Brian J Reid, Daniel Raftery, Thomas L Vaughan
INTRODUCTION/OBJECTIVES: Incidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett's esophagus (BE), but a key challenge remains identifying individuals at highest risk, since most with reflux do not develop BE, and most with BE do not progress to cancer. Metabolomics represents an emerging approach for identifying novel biomarkers associated with cancer development...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
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