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Chlortalidone

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https://www.readbyqxmd.com/read/27754015/br-04-1management-of-treatment-resistant-hypertension
#1
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642926/br-04-1management-of-treatment-resistant-hypertension
#2
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27497654/uhplc-ms-ms-method-with-protein-precipitation-extraction-for-the-simultaneous-quantification-of-ten-antihypertensive-drugs-in-human-plasma-from-resistant-hypertensive-patients
#3
Amedeo De Nicolò, Valeria Avataneo, Franco Rabbia, Gabriele Bonifacio, Jessica Cusato, Cristina Tomasello, Elisa Perlo, Paolo Mulatero, Franco Veglio, Giovanni Di Perri, Antonio D'Avolio
Today the management of resistant hypertension is a critical health problem: the main difficulty on this field is the discrimination of cases of poor therapeutic adherence from cases of real resistance. This gives rise to the need of high throughput and reliable quantification methods for the Therapeutic Drug Monitoring (TDM) of antihypertensive drugs. The aim of this work was the development and validation of a UHPLC-Tandem mass spectrometry assay for this application and its use in plasma from patients with resistant hypertension...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26850731/multiwalled-carbon-nanotubes-dispersive-solid-phase-extraction-coupled-with-uplc-esi-ms-ms-for-simultaneous-determination-of-10-illegal-adulterants-in-antihypertensive-functional-foods
#4
Jielan Hu, Li Zeng, Ling He, Fan You, Chengjun Sun
A reliable method for simultaneous determination of 10 illegal adulterants including chlortalidone, hydrochlorothiazide, indapamide, metoprolol, nifedipine, nimodipine, nitrendipine, reserpine, triamterene and valsartan in antihypertensive functional foods by ultra-high-performance liquid chromatography coupled with electrospray ionization-tandem mass spectrometry is presented in this article. The target chemicals were extracted with acetonitrile ultrasonically and cleaned up using multiwalled carbon nanotubes-dispersive solid-phase extraction...
May 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/26832747/use-of-diuretics-is-not-associated-with-mortality-in-patients-admitted-to-the-emergency-department-results-from-a-cross-sectional-study
#5
Dominik G Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C Sauter, Valentin Fuhrmann, Aristomenis K Exadaktylos
BACKGROUND: Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality. METHODS: In this cross sectional analysis, all emergency room patients 2010 and 2011 at the Inselspital Bern, Switzerland were included. A multivariable logistic regression model was performed to assess the association between pre-existing diuretic medication and 28 day mortality...
2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26528899/identification-and-proportion-of-the-enantiomers-of-the-antihypertensive-drug-chlortalidone-in-its-form-ii-by-high-quality-single-crystal-x-ray-diffraction-data
#6
Leandro M Santos, Olimpia M M Santos, Paula Freire Mendes, Iara Maria Landre Rosa, Cameron Capeletti da Silva, Rudy Bonfilio, Magali B de Araujo, Vanessa B Boralli, Antônio C Doriguetto, Felipe T Martins
Chlortalidone (CTD) is a diuretic drug largely used as part of antihypertensive therapies. It is marketed as an equimolar mixture of its enantiomers in the racemic crystal phase named Form I, despite of the higher aqueous solubility of another crystal form. The latter, named Form II, was thought to contain both enantiomers as a racemic conglomerate, i.e., in the form of a mixture of crystals, half of which consists solely of the (R)-enantiomer, the other half the (S)-enantiomer. The occurrence of both enantiomers in individual crystals of CTD Form II was demonstrated in this study...
January 25, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25840433/simultaneous-determination-of-10-adulterants-in-antihypertensive-functional-foods-using-multi-walled-carbon-nanotubes-dispersive-solid-phase-extraction-coupled-with-high-performance-liquid-chromatography
#7
Li Zeng, Yongxin Li, Xin Wu, Jing Zhang, Juan Xie, Chengjun Sun
Consumption of functional foods based on extracts from selected herbs to alleviate hypertension is an increasingly common practice in China. Adulteration of these foods with pharmaceuticals can significantly impact a consumer's health. To control the quality of the functional foods effectively, a method for the simultaneous determination of 10 common adulterants including chlortalidone, hydrochlorothiazide, indapamide, metoprolol, nifedipine, nimodipine, nitrendipine, reserpine, triamterene and valsartan in antihypertensive functional foods was developed...
October 2015: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/25325125/treating-essential-hypertension-the-first-choice-is-usually-a-thiazide-diuretic
#8
REVIEW
(no author information available yet)
We concluded in 2004 that the first-choice treatment for hypertension in adults was single-agent therapy with the thiazide diuretic chlortalidone or, when this drug is not available, the thiazide diuretic hydrochlorothiazide. As of early 2014, does evidence challenge this choice in adults without diabetes or cardiovascular or renal disease? To answer this question, we reviewed the available evidence, using the standard Prescrire methodology. The current treatment threshold for hypertensive adults without diabetes or cardiovascular or renal disease is blood pressure above 160/100 mmHg or 160/90 mmHg, with some uncertainty over which diastolic threshold should be used...
September 2014: Prescrire International
https://www.readbyqxmd.com/read/24746411/taste-acceptability-of-pulverized-brand-name-and-generic-drugs-containing-amlodipine-or-candesartan
#9
RANDOMIZED CONTROLLED TRIAL
Peter Uestuener, Alessandra Ferrarini, Maristella Santi, Chiara Mardegan, Mario G Bianchetti, Giacomo D Simonetti, Gregorio P Milani, Sebastiano A G Lava
Trials with pulverized brand-name antihypertensive drugs suggest that, from the perspective of taste acceptability, crushed candesartan, chlortalidon, hydrochlorothiazide, lercanidipine and lisinopril should be preferred to pulverized amlodipine, atenolol, bisoprolol, enalapril, irbesartan, losartan, ramipril, telmisartan and valsartan. Brand-name antihypertensive drugs and the corresponding generic medicines have never been compared with respect to their taste acceptability. We therefore investigated among healthy health care workers the taste acceptability of a pulverized 1 mg-test dose of the brand-name and two generics containing either the dihydropyridine calcium-channel blocker amlodipine (Norvasc(®), Amlodipin-Mepha(®) and Amlodipin Pfizer(®)) or the angiotensin receptor antagonist candesartan (Atacand(®), Cansartan-Mepha(®) and Pemzek(®))...
July 1, 2014: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/24227012/analysis-of-sartans-a-review
#10
REVIEW
Izabela Muszalska, Agnieszka Sobczak, Agnieszka Dołhań, Anna Jelińska
The risk of cardiovascular diseases is closely related to hypertension, high cholesterol levels, and diabetes. When these risk factors appear together they are referred to as a metabolic syndrome. In the treatment of cardiovascular diseases, a combination of antihypertensive, hypolipemiant, and antidiabetic drugs is often applied. Diuretics (chlortalidone, hydrochlorothiazide, etc.) and angiotensin II receptors antagonist (sartans) are used to control hypertension, whereas statins (fluvastatin, simvastatin, etc...
January 2014: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/24070321/azilsartan-medoxomil-in-the-treatment-of-hypertension-the-definitive-angiotensin-receptor-blocker
#11
REVIEW
Vivencio Barrios, Carlos Escobar
INTRODUCTION: Azilsartan medoxomil is the newest angiotensin receptor blocker marketed for the treatment of arterial hypertension. The aim of this article was to review the available evidence about this drug alone or combined with other antihypertensive agents in the treatment of hypertensive population. AREAS COVERED: For this purpose, a search on MEDLINE and EMBASE databases was performed. The MEDLINE and EMBASE search included both medical subject headings (MeSHs) and keywords including azilsartan or azilsartan medoxomil or angiotensin receptor blockers or renin angiotensin system or chlorthalidone and hypertension...
November 2013: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/23245251/screening-of-pharmacologic-adulterant-classes-in-herbal-formulations-using-voltammetry-of-microparticles
#12
Antonio Doménech-Carbó, Mariele Martini, Leandro Machado de Carvalho, Carine Viana, María Teresa Doménech-Carbó, Miguel Silva
A solid state electrochemical method for screening different families of adulterant chemicals illegally added to commercial phytotherapuetic formulations is described. The proposed method, based on the voltammetry of microparticles approach, permits a fast and sensitive way to distinguish between anorexics (amfepramone, fenproporex, sibutramine), benzozodiazepinic anxiolytics (clonazepam, flurazepam, alprazolam, midazolam, medazepam, chlordiazepoxide, diazepam), antidepressants (bupropione, fluoxetine, sertraline, paroxetine), diuretics (hydrochlorothiazide, furosemide, chlortalidone, amiloride, spironolactone), and hypoglycemics (glimepiride, chlorpropamide, glibenclamide) based on characteristic voltammetric signals recorded on solid micro- or nanosamples attached to graphite electrodes immersed into aqueous electrolytes...
February 23, 2013: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/23029982/-are-all-diuretics-equal-for-the-treatment-of-hypertensive-patients
#13
REVIEW
B Waeber, F Feihl
Thiazide (hydrochlorothiazide,...) and thiazide-like (chlortalidone, indapamide,...) diuretics are widely used to treat hypertensive patients. There is growing evidence that these diuretics are not interchangeable and that it might be preferable to choose a thiazide-like diuretic whenever the use of a diuretic is considered. This is in order to prevent optimally the development of cardiovascular complications and the occurrence of metabolic side effects, in particular diabetes.
September 12, 2012: Revue Médicale Suisse
https://www.readbyqxmd.com/read/22953322/observing-the-niceties-of-hypertension-management
#14
REVIEW
E E Morrison, E J Turtle, D J Webb
National Institute for Health and Clinical Excellence guidance for the clinical management of hypertension, published last year, proposes a step change in UK clinical practice.1 Although broadly helpful, there are some concerns about its implementation. Ambulatory blood pressure monitoring for diagnosis of hypertension, though logical, will place an additional financial burden on primary care at a time of austerity. Home blood pressure measurement may be a more practical option. Previous guidance recommended the used of thiazide diuretics as a first-line treatment option...
2012: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/22499290/persistence-and-adherence-to-antihypertensive-treatment-in-relation-to-initial-prescription-diuretics-versus-other-classes-of-antihypertensive-drugs
#15
RANDOMIZED CONTROLLED TRIAL
Valentina Trimarco, Giovanni de Simone, Raffaele Izzo, Nicola De Luca, Renata Giudice, Marina Marino, Silvia Damiano, Francesco Rozza, Bruno Trimarco, Gianfranco Di Renzo
BACKGROUND: The use of thiazide diuretics in the treatment of hypertension is widely considered as a first-line treatment, given the efficacy and low cost of this class of drugs. This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persistence on treatment. OBJECTIVES: In a multicentre, open-label randomized study we compared adherence and persistence to therapy of chlortalidone versus other treatments, as a first-line antihypertensive therapy...
June 2012: Journal of Hypertension
https://www.readbyqxmd.com/read/22068445/-retinal-microangiopathy-in-arterial-hypertension-as-an-early-marker-of-a-cerebral-macroangiopathy
#16
G Michelson, T Engelhorn, A Dörfler
HISTORY AND ADMISSION FINDINGS: A 54-year-old man reported having had nonspecific attacks of dizziness. His BMI was 27.7. Since 11 years he had been treated for arterial hypertension and had received oral medication for type 2 diabetes for one year. The latest blood pressure value was 134/109 mm Hg during treatment with a combination of atenolol, chlortalidone und hydralazine-HCl; furthermore hr received simvastatin, metformin, glimepirid und ramipril. A standardized telemedical imaging of the retina ("talkingeyes (®) ") was undertaken, revealing focal and generalized arteriolar narrowing of the retinal vessels and a retinal microinfarction (cotton wool spot) in the right eye...
November 2011: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/21125811/antioxidative-effects-of-thiazide-diuretics-in-refractory-hypertensive-patients-a-randomized-crossover-trial-of-chlortalidone-and-trichlormethiazide
#17
RANDOMIZED CONTROLLED TRIAL
Koichi Sato, Yasuaki Dohi, Masayoshi Kojima, Hiroyuki Takase, Shin Suzuki, Shigenori Ito
Some thiazide diuretics seem to exert antioxidant effects, which may be beneficial in the management of hypertension. Although many large-scale clinical trials on hypertension have proved that thiazide diuretics confer significant reductions in stroke and cardiovascular events, most of these trials preferentially used chlortalidone. Therefore, the difference in antioxidant effects between chlortalidone (CAS 77-36-1; 12.5 mg/day) and another thiazide diuretic, trichlormethiazide (CAS 133-67-5; 1 mg/day) was studied...
2010: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/20922954/development-and-validation-of-an-hplc-ms-ms-method-for-determining-the-thiazolidinone-pg15-in-rat-plasma
#18
Flávia D T Uchôa, Eduardo C Palma, Natalia F Souza, Maria C A Lima, Suely L Galdino, Ivan R Pitta, Teresa Dalla Costa
A rapid, sensitive, and simple HPLC/MS/MS method was developed and validated for the determination of (5Z,E)-3-[2-(4-chlorophenyl)-2-oxoethyl]-5-(1H-indol-3-ylmethylene)-thiazolidine-2, 4-dione (PG15) in rat plasma using chlortalidone as an internal standard (IS). Analyses were performed using a C18 column and isocratic elution with acetonitrile-water (90 + 10, v/v) containing 10 mM ammonium hydroxide (pH 8.0) as the mobile phase pumped at 0.3 mL/min. Detection was performed by MS with negative ion mode electrospray ionization...
July 2010: Journal of AOAC International
https://www.readbyqxmd.com/read/19911691/-which-role-for-calcium-antagonists-in-the-treatment-of-arterial-hypertension-after-the-accomplish-study
#19
Isabelle Mottu, Arnaud Perrier
The recently published ACCOMPLISH study concludes that the combination of a dihydropyridin calcium-antagonist (amlodipine) with an angiotensin-converting enzyme inhibitor (ACEI) is superior to the classical ACE-hydrochlorothiazide diuretic association in terms of cardiovascular risk reduction in high-risk hypertensive patients. These results contrast with those of the older ALLHAT study in which amlodipine was not superior to another thiazide diuretic (chlortalidone). This paper presents the results of both studies and attempts to put them in the larger perspective of the management of arterial hypertension...
October 14, 2009: Revue Médicale Suisse
https://www.readbyqxmd.com/read/19205547/improvement-of-diastolic-function-after-regression-of-left-ventricular-hypertrophy
#20
Raúl Teniente-Valente, Sergio Solorio, Enrique Vargas-Salado, Carlos Aguirre-Vázquez, Martha A Hernández-González, José Antonio Olvera-Lopez, Leticia Rodríguez-Mariscal, Miguel Angel Luna-Ruiz, José Manuel Guillén Contreras, Blanca Olivia Murillo Ortiz
OBJECTIVE: To evaluate the diastolic function after regression of left ventricular hypertrophy, in mild to moderate hypertension treated with angiotensin converting enzyme(ACE) inhibitor and, if necessary, with a diuretic. METHODS: Ninety-eight hypertensive patients with left ventricular hypertrophy (LVH) and abnormal left ventricle diastolic function indexes received captopril (Capotena) 50 to 200 mg/day plus chlortalidone during 12 months to reach blood pressure control, defined as a diastolic blood pressure < or =90 and systolic blood pressure < or =140 mm Hg...
October 2008: Archivos de Cardiología de México
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