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Rok Accetto, Jiri Widimsky, Josip Vincelj, Yuriy Sirenko, Irina Chazova Yevgenyevna, Breda Barbic Zagar
BACKGROUND AND AIM: The aim of the study was to establish the effect of valsartan and combination of valsartan and hydrochlorothiazide (HCTZ) on pulse wave velocity (PWV) and central blood pressure (CBP) in a large population of patients with mild to moderate arterial hypertension. METHODS: This was an international, multicentre, open-label, prospective trial. After one week of washout in previously treated patients, 74 subjects were treated with valsartan or valsartan combined with HCTZ for 16 weeks according to the protocol...
2018: Kardiologia Polska
Maximilian Wiesmann, Carmen Capone, Valerio Zerbi, Laura Mellendijk, Arend Heerschap, Jurgen A H R Claassen, Amanda J Kiliaan
AIMS: Hypertension, a risk factor for Alzheimer's disease (AD), is a treatable condition, which offers possibilities for prevention of AD. Elevated angiotensin II (AngII) is an important cause of essential hypertension. AngII has deleterious effects on endothelial function and cerebral blood flow (CBF), which may contribute to AD. AngII blocking agents can thus provide potential candidates to reduce AD risk factors in hypertensive patients. METHODS: We studied the effect of 2 months induced hypertension (AngII-infusion via osmotic micropumps) on systolic blood pressure (SBP) and CBF in 10 months-old wild-type (WT) C57bl/6j and AβPPswe/PS1ΔE9 (AβPP/PS1) mice, and treatment with two different antihypertensives, 1) eprosartan mesylate (EM, 0...
2015: Current Alzheimer Research
Pedro Marques da Silva, Uwe Haag, Julian F Guest, John E Brazier, Marco Soro
BACKGROUND: A post-hoc analysis was performed on the data from a 54 weeks phase III study ( identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using the MINICHAL and EQ-5D instruments. METHODS: Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period...
February 21, 2015: Health and Quality of Life Outcomes
Pedro Marques da Silva, Uwe Haag, Julian F Guest, John E Brazier, Marco Soro
BACKGROUND: A post-hoc analysis was performed on the data from a 54 weeks phase III study ( identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using the MINICHAL and EQ-5D instruments. METHODS: Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period...
December 2015: Health and Quality of Life Outcomes
Marta de Diego, Jorge Soto, Sigrid Mennickent
A simple and rapid stability-indicating liquid chromatographic method was developed and validated for the simultaneous determination of lisinopril and hydrochlorotiazide (HCTZ) in drug substances and dosage forms in the presence of degradation products. Forced degradation studies were conducted on the pure drugs under hydrolytic, oxidative, thermal and photolytic conditions. A chromatographic separation of the two drugs and its degradation products was achieved with an RP-18 column, using methanol, acetonitrile and phosphate buffer (pH 7...
November 2014: Journal of Chromatographic Science
R R Tjandrawinata, E Setiawati, D A Yunaidi, I D Santoso, A Setiawati, L W Susanto
BACKGROUND: The present study was conducted to compare the bioavailability of 2 formulations of fixed-dose combination of bisoprolol fumarate 5 mg and hydrochlorotiazide (HCT) 6.25 mg film-coated tablet (test and reference formulations). METHODS: This study was a randomized, single-blind, 2-period, 2-sequence cross-over study which included 18 healthy adult male and female subjects under fasting condition. The pharmacokinetic parameters, AUCt, AUCinf, Cmax, tmax, and t½ were determined based on the concentrations of bisoprolol (CAS 66722-44-9) and HCT (CAS 58-93-5), using ultra-performance liquid chromatography with tandem mass spectrometer detector (UPLC-MS/MS)...
May 2013: Drug Research
S Abdala, D Martín-Herrera, D Benjumea, S Dévora Gutiérrez
ETHNOPHARMACOLOGICAL RELEVANCE: Smilax canariensis is an endemic species of the Canary Islands, popularly known as "Zarzaparrilla sin espinas". The rhizome, leaves and stem of this species has wide use in folk medicine practice on the islands, where they are habitually employed as diuretic. AIM OF THE STUDY: In this paper we report on the diuretic activity in experimental animals of several fractions of the methanol extract of this species. MATERIALS AND METHODS: Four fractions of the methanol extract of the rhizomes, leaves and stem of Smilax canariensis (50 and 100mg/kg), Furosemide and Hydrochlorotiazide (10mg/kg), were orally administered to laboratory animals to evaluate their diuretic activity...
March 27, 2012: Journal of Ethnopharmacology
J M Moreno, R Peréz-Abud, R Wangensteen, I Rodríguez Gómez, I López Merino, A Osuna, F Vargas
Thyroid disorders are accompanied by major changes in renal sodium handling and blood pressure. Sodium transporters play a crucial role in regulating sodium excretion. We determined the function and expression of type 3 Na/H (NHE3) exchanger, type 2 Na+K+2Cl co-transporter (NKCC2) co-transporter, NaCl co-transporter (NCC) cotransporter, and epithelial sodium channel (ENaC) in hypoand hyperthyroid rats at 6 weeks after each thyroid disorder induction. We measured the renal response to functional blockade of the tubular sodium transporters, using acetazolamide to inhibit the activity of NHE3, furosemide for NKCC2, hydrochlorotiazide for NCC, and amiloride for ENaC...
September 2012: Journal of Endocrinological Investigation
C Fernández, M González-Doncel, J Pro, G Carbonell, J V Tarazona
The Henares-Jarama-Tajo river system is the largest drainage basin in the Province of Madrid, Spain. This area is characterized by the presence of intensive urban and industrial activities influenced by a continental Mediterranean climate with rainfalls presenting substantial fluctuations along the different seasons. This research aimed to monitor seasonal variations in concentrations of 22 pharmaceutically active compounds (PhACs) in this river system and to establish the potential risk of sublethal effects on aquatic organisms...
January 1, 2010: Science of the Total Environment
N A Musikhina, O V Iuferova, L I Gapon, E A Makhneva, E A Belikova, T I Petelina, V V Todosiĭchuk
AIM: To study endothelial function and vascular elasticity in hypertensive patients with coronary heart disease (CHD) and approaches to correction of the impairments with felodipin and perindopril. MATERIAL AND METHODS: The trial included 34 hypertensive patients with CHD and 17 controls free of cardiovascular diseases. The above cardiovascular patients were randomized into two groups: 15 patients of group 1 received felodipin, 19 patients of group 2 were given perindopril...
2009: Terapevticheskiĭ Arkhiv
Bart Westendorp, Inge Hamming, Mariusz K Szymanski, Gerjan Navis, Harry van Goor, Hendrik Buikema, Wiek H van Gilst, Regien G Schoemaker
Diuretics, when added to angiotensin-converting enzyme inhibitors (ACE inhibitors) treatment, can augment the response to ACE inhibitors, but may have adverse effects on renal function, which negatively affect prognosis. While in heart failure rats combined therapy initially improved cardiac function and prognosis, this benefit was completely lost at later stages. We now studied renal effects of adding hydrochlorothiazide to ACE inhibitor after myocardial infarction in rats. Rats were randomized to ACE inhibitor quinapril monotherapy or quinapril with add-on hydrochlorothiazide...
January 14, 2009: European Journal of Pharmacology
Rafael Barreiro-Iglesias, Lev Bromberg, Marina Temchenko, T Alan Hatton, Carmen Alvarez-Lorenzo, Angel Concheiro
Potential utility of copolymers comprising Pluronic (PEO-PPO-PEO) surfactants covalently conjugated with poly(acrylic acid) (PAA) as excipients for sustained-release tablets was explored. Apparent particle density, particle size distribution, Carr index, thermal stability, and compression behavior of the Pluronic-PAA copolymers were characterized. Tablets prepared by direct compression of blends of Pluronic-PAA copolymers were evaluated on the basis of their thermomechanical profile, crushing strength, friability, and drug release properties...
December 2005: European Journal of Pharmaceutical Sciences
Dijana B Jovanović, Dj Jovović, Jasmina Varagić, Jovan Dimitrijević, Zorica Dragojlović, Ljubica Djukanović
INTRODUCTION: The role of hypertension in chronic renal failure (CRF) progression was described in 1914 by Volhard and Fahr [1], in 1940 by Rite and colleagues [2] and subsequently many studies described the effects of various antihypertensive drugs on regulation of blood pressure and CRF progression. The recent experimental and clinical studies especially emphasized the role of angiotensin converting enzyme (ACE) inhibitors in the regulation of hypertension and slowing down of CRF progression, but there are still issues for discussion and disagreement [2-14]...
March 2002: Srpski Arhiv za Celokupno Lekarstvo
D Rizzoni, E Agabiti-Rosei
This paper discusses the role of endothelial dysfunction in human hypertension, especially in relation to small resistance artery structure, as well as the effects of anti-hypertensive drugs on endothelial function of small arteries in human and experimental hypertension. A significant impairment of endothelial function was observed in human essential hypertension as well as in secondary forms of hypertension. No correlation was observed with vascular structure. In animal models of genetic hypertension there is substantial evidence for a beneficial effect of anti-hypertensive treatment with angiotensin converting enzyme (ACE) inhibitors, calcium entry blockers and angiotensin II receptor blockers on endothelial function in small resistance arteries...
November 2001: Journal of Cardiovascular Pharmacology
A Medvedovici, C Mircioiu, V David, D S Miron
The main parameters considered in optimizing the liquid extraction and quantitative assay were the yield, precision, limit of quantification, time required for extraction and concentration, and quantity of solvent. The influence on these parameters of the following factors was examined: nature of the extracting solvent, quantity of solvent, co-extraction solvent, and duration of stirring. Instead of equilibrium parameters of the involved thermodynamic system, a kinetic approach was preferred in terms of the effective partition 'constant', which is not really constant but a function of time and extraction conditions...
April 2000: European Journal of Drug Metabolism and Pharmacokinetics
O Hanon, G Franconi, J J Mourad, A Baleydier, I Croce, X Girerd
OBJECTIVES: To compare antihypertensive therapeutic strategies and efficacy whether the physicians were aware or not of the calculated cardiovascular risk at 10 years obtained from the Framingham equation. It was also possible to evaluate the concordance of the general physicians estimation of the cardiovascular risk with the calculated percentage. METHODS: The participation of 953 general physicians to the study allowed to achieve an estimation of the absolute cardiovascular risk for 1,243 hypertensives...
August 2000: Archives des Maladies du Coeur et des Vaisseaux
P Marín
Hydrochlorotiazide may cause pulmonary dema. We report two female patients aged 58 and 69 years old, who after the ingestion of this diuretic, were admitted to an intensive care unit with fever, digestive symptoms, severe dyspnea, hypotension and a hemodynamic pattern resembling hypovolemia. Both had a good response to volume repletion and vasoactive drugs. Despite the severity of the clinical picture, they had a full and fast recovery. This type of reaction to hydrochlorotiazide is probably idiosyncratic and must be considered in the differential diagnosis of pulmonary edema...
December 1996: Revista Médica de Chile
M B Oliveri, C Mautalen, M Mega, E Rossi
Congenital erythropoietic porphyria (CEP) is a rare disorder of heme biosynthesis. Skeletal abnormalities have been described in patients with this disease. We report a 25-year-old woman with osteodystrophy from CEP. On examination, mild hepatosplenomegaly, multiple hyperpigmented scars, hypertrichosis, erythrodontia and red coloration of urine were found. Biochemical studies showed increased serum levels of alkaline phosphatase, fasting and total 24-h urinary calcium excretion. Serum 250H vitamin-D concentration was low due to avoidance of sun exposure...
January 1994: Bone
T Hedner, B Persson, G Berglund
Ketanserin is a serotonin (S2) blocker that reduces blood pressure (BP) in patients with essential hypertension preferentially by a reduction of peripheral vascular resistance. Heart rate is generally not affected or slightly reduced. When given in monotherapy on a 40 mg b.i.d. regimen, ketanserin reduces diastolic BP as effectively as metoprolol 100 mg b.i.d. or hydrochlorotiazide 25 mg b.i.d. The incidence of adverse reactions is low and comparable to these reference drugs. A satisfactory BP control is provided over a 24-h interval on a 40 mg b...
1985: Journal of Cardiovascular Pharmacology
L R Tamburrini, M Di Monte
A clinical trial was performed to assess the association of captopril-hydrochlorotiazide in a large population of hypertensive outpatients divided into two groups: elderly subjects and control group of adults. The hypotensive effect was evaluated and statistical differences between basal values after some months of treatment were highly significant. Together with results, variations in blood as a result of lower pressure are reported, whereas renal functions, and the glucose and electrolytic metabolism remained constant...
May 1991: Minerva Medica
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