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https://www.readbyqxmd.com/read/27908252/the-combination-of-new-immunotherapy-and-radiotherapy-a-new-potential-treatment-for-locally-advanced-non-small-cell-lung-cancer
#1
Paola Claudia Sacco, Paolo Maione, Cesare Guida, Cesare Gridelli
Lung cancer is the main reason of cancer death worldwide. About 30% of non-small-cell lung cancer (NSCLC) cases are diagnosed with locally advanced disease (stage III). This is a mixed population including patients who have far more extensive and bulky disease than others. Management of these patients continue to be a challenge; frequently, patients have both local recurrence and distant metastases in this stage and the prognosis is very poor with a 5-year overall survival estimated between 3% and 7% for inoperable disease...
December 1, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27859830/fast-evaluation-and-monitoring-of-ingenol-mebutate-treatment-of-multiple-basal-cell-carcinomas-by-in-vivo-hand-held-reflectance-confocal-microscopy
#2
E Manubens, A Barreiro, A Bennassar, S Podlipnik, N Moreno, P Iglesias, J Malvehy, S Puig
Patients presenting multiple basal cell carcinomas (BCCs) are increasing and their management often entails a challenge for dermatologists(1) . In vivo reflectance confocal microscopy (RCM) has demonstrated in a recent metanalysis a very good performance in the diagnosis of BCC, opening a new alternative in the evaluation of these patients(2) . An 82 year old man with history of approximately 30 BCC over the last 30 years was referred to our clinic. This article is protected by copyright. All rights reserved...
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27733159/moderate-intensity-statin-therapy-seems-ineffective-in-primary-cardiovascular-prevention-in-patients-with-type-2-diabetes-complicated-by-nephropathy-a-multicenter-prospective-8%C3%A2-years-follow-up-study
#3
Ferdinando Carlo Sasso, Nadia Lascar, Antonella Ascione, Ornella Carbonara, Luca De Nicola, Roberto Minutolo, Teresa Salvatore, Maria Rosaria Rizzo, Plinio Cirillo, Giuseppe Paolisso, Raffaele Marfella
BACKGROUND: Although numerous studies and metanalysis have shown the beneficial effect of statin therapy in CVD secondary prevention, there is still controversy such the use of statins for primary CVD prevention in patients with DM. The purpose of this study was to evaluate the occurrence of total major adverse cardio-vascular events (MACE) in a cohort of patients with type 2 diabetes complicated by nephropathy treated with statins, in order to verify real life effect of statin on CVD primary prevention...
October 13, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27496262/amiodarone-or-lidocaine-for-cardiac-arrest-a-systematic-review-and-meta-analysis
#4
REVIEW
F Sanfilippo, C Corredor, C Santonocito, G Panarello, A Arcadipane, G Ristagno, T Pellis
BACKGROUND: Guidelines for treatment of out-of-hospital cardiac arrest (OOH-CA) with shockable rhythm recommend amiodarone, while lidocaine may be used if amiodarone is not available. Recent underpowered evidence suggests that amiodarone, lidocaine or placebo are equivalent with respect to survival at hospital discharge, but amiodarone and lidocaine showed higher hospital admission rates. We undertook a systematic review and meta-analysis to assess efficacy of amiodarone vs lidocaine vs placebo...
October 2016: Resuscitation
https://www.readbyqxmd.com/read/27404944/clinical-features-and-complications-of-the-hla-b27-associated-acute-anterior-uveitis-a-metanalysis
#5
Enzo Maria D'Ambrosio, Maurizio La Cava, Paolo Tortorella, Magda Gharbyia, Michelangelo Campanella, Ludovico Iannetti
In this article, we report a literature-based metanalysis we have conducted to outline the clinical features of the HLA-B27 Acute Anterior Uveitis (AAU). The examined material was based on observational studies in which participants were affected by Acute Anterior Uveitis and divided into HLA B27+ and HLA B27-. We performed a search on articles with the words "HLA B27 uveitis" dated before May 2014. Among these, 29 articles were selected for a second review. After a further evaluation, 22 articles were analyzed...
July 12, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27374048/cardiac-rehabilitation-is-safe-and-effective-also-in-the-elderly-but-don-t-forget-about-drugs
#6
Donatella Del Sindaco, Maria Denitza Tinti, Giovanni Pulignano, Stefano Tolone, Giovanni Minardi, Massimo Uguccioni, Antonio Lax
In the setting of heart failure (HF) pharmacotherapy demonstrates a quantifiable improvement in exercise tolerance also in HF with preserved ejection fraction (HFpEF). For patients with HFpEF, often older, with higher prevalence of hypertension, diabetes mellitus, atrial fibrillation and other comorbidities, endpoints such as quality of life and functional capacity may be more clinically relevant. However several study show as the use of ACE-I and B-blocker were lesser than expected. Beta-blocker therapy is the keystone of pharmacotherapy of HF patients and exercise training is the essential core of rehabilitation programs, it is important to elucidate the relationship between these therapies...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27133556/is-there-really-a-relationship-between-serum-vitamin-d-25ohd-levels-and-the-musculoskeletal-pain-associated-with-statin-intake-a-systematic-review
#7
Claudia Alejandra Pereda, Maria Betina Nishishinya
INTRODUCTION: Musculoskeletal pain associated to statin use, is the most common adverse event, leading to cessation of treatment. Several studies proposed Vitamin D deficiency to increase the risk of pain associated to statin intake. OBJECTIVES: To evaluate whether vitamin D status is linked to musculoskeletal pain associated to statin use. METHODS: We performed a systematic review based on electronic searches through MEDLINE, Cochrane Central and EMBASE to identify studies that 1) included patients on statin therapy 2) with vitamin D serum levels assessment, 3) in relation to musculoskeletal pain...
April 25, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27083761/in-utero-treatment-of-congenital-cytomegalovirus-infection-with-valacyclovir-in-a-multicenter-open-label-phase-ii-study
#8
Marianne Leruez-Ville, Idir Ghout, Laurence Bussières, Julien Stirnemann, Jean-François Magny, Sophie Couderc, Laurent J Salomon, Tiffany Guilleminot, Philippe Aegerter, Guillaume Benoist, Norbert Winer, Olivier Picone, François Jacquemard, Yves Ville
BACKGROUND: Congenital infection with human cytomegalovirus is a major cause of morbidity and mortality. A randomized controlled trial showed that high-dosage valacyclovir prevents cytomegalovirus disease in transplant recipients. Fetuses showing ultrasound features of infection are at high risk of being symptomatic at or before birth. In a pilot study, oral administration of high-dosage valacyclovir to mothers significantly decreased viral load and produced therapeutic concentrations in the blood of infected fetuses...
October 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27083592/epirubicin-based-compared-with-docetaxel-based-chemotherapy-for-advanced-gastric-carcinoma-a-systematic-review-and-meta-analysis
#9
REVIEW
Roberto Petrioli, Giandomenico Roviello, Laura Zanotti, Franco Roviello, Karol Polom, Alberto Bottini, Luigi Marano, Edoardo Francini, Daniele Marrelli, Daniele Generali
Docetaxel or Epirubicin-based regimens are both approved for the treatment of metastatic gastric cancer. We perform a systemic review with metanalysis to evaluate the efficacy and toxicities of docetaxel-based chemotherapy compared with epirubicin-containing regimens. A metaanalysis of randomized studies in accordance with the preference guidelines for reported items in systematic reviews and meta-analyses is performed in which the databases of PubMed, the Cochrane Library, and the ASCO University Meeting were searched for relevant publications...
June 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27042796/hybrid-coronary-revascularization-an-attractive-alternative-between-actual-results-and-future-trends
#10
Antonio Nenna, Cristiano Spadaccio, Mario Lusini, Raffaele Barbato, Massimo Chello, Francesco Nappi
Optimal revascularization strategy in patients with multi-vessel coronary artery disease remains a matter of debate, with advantages and disadvantages in both surgical and percutaneous procedures. A combined approach to achieve coronary revascularization, termed "hybrid coronary revascularization" (HCR), has been recently introduced in clinical practice. HCR is defined as a scheduled combination of surgical left internal mammary artery to left anterior descending (LIMA-LAD) grafting and percutaneous treatment of at least one non-LAD coronary arteries, with both procedures planned and performed within a defined time limit...
April 2016: Surgical Technology International
https://www.readbyqxmd.com/read/26997707/antipsychotic-trials-in-schizophrenia-from-india-a-systematic-review-and-meta-analysis
#11
S Grover, S Sarkar
Ethnic and regional variations have been found in the pharmacological treatment response. Though many efficacy studies have been conducted in India for antipsychotic treatment modalities of schizophrenia, there is a lack meta-analytic data of the existing literature from India. This study aimed to conduct a systematic review and meta-analysis of the antipsychotic treatment trials of schizophrenia in the Indian context. All controlled trials from India evaluating the clinical efficacy of antipsychotics in patients with schizophrenia were evaluated and 28 trials were included in the metanalysis...
November 2015: Indian Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26992927/laparoscopic-versus-robotic-right-colectomy-technique-and-outcomes
#12
Giampaolo Formisano, Pasquale Misitano, Giuseppe Giuliani, Giulia Calamati, Lucia Salvischiani, Paolo Pietro Bianchi
Minimally invasive surgery has gained worldwide acceptance in the treatment of colonic cancer in the last decades, thanks to its well-known advantages in short-term outcomes. Nevertheless, the penetrance of minimally invasive colorectal surgery still remains low. Few studies and metanalysis, to date, have analyzed the results of robotic versus laparoscopic colorectal surgery, often with conflicting conclusions. The robotic platform, thanks to its technological features, may potentially overcome the limitation of standard laparoscopy, especially when performing a complete mesocolic excision resection and an intracorporeal anastomosis...
March 2016: Updates in Surgery
https://www.readbyqxmd.com/read/26942258/helicobacter-pylori-and-gastric-or-duodenal-ulcer
#13
REVIEW
(no author information available yet)
In patients with gastric or duodenal ulcer associated with Helicobacter pylori, treatment of the infection improves healing and prevents complications and recurrences. The drug regimen generally consists of a high-dose proton-pump inhibitor (PPI) such as omeprazole plus antibiotics. Using the standard Prescrire methodology, we conducted a review of the literature in order to determine the standard empirical antibiotic regimen for H. pylori infection in adults with gastric or duodenal ulcer in France. In 2015, due to an increase in H...
January 2016: Prescrire International
https://www.readbyqxmd.com/read/26596545/clinical-application-of-micronucleus-test-in-exfoliated-buccal-cells-a-systematic-review-and-metanalysis
#14
REVIEW
Claudia Bolognesi, Stefano Bonassi, Siegfried Knasmueller, Michael Fenech, Marco Bruzzone, Cecilia Lando, Marcello Ceppi
The micronucleus assay in uncultured exfoliated buccal mucosa cells, involving minimally invasive sampling, was successfully applied to evaluate inhalation and local exposure to genotoxic agents, impact of nutrition and lifestyle factors. The potential use of the assay in clinics to monitor the development of local oral lesions and as an early biomarker for tumors and different chronic disorders was also investigated. A systematic review of the literature was carried out focusing on the clinical application of the assay...
October 2015: Mutation Research. Reviews in Mutation Research
https://www.readbyqxmd.com/read/26556071/from-mind-to-body-is-mental-practice-effective-on-strength-gains-a-meta-analysis
#15
REVIEW
João Paulo Manochio, Eduardo Lattari, Eduardo Matta Mello Portugal, Renato Sobral Monteiro-Junior, Flávia Paes, Henning Budde, Paulo de Tarso Veras Farinatti, Oscar Arias-Carrión, Mirko Wegner, Mauro Giovanni Carta, Gioia Mura, Nuno Barbosa Ferreira Rocha, Leonardo Ferreira Almada, Antonio Egidio Nardi, Ti-Fei Yuan, Sergio Machado
Mental practice is an internal reproduction of a motor act (whose intention is to promote learning and improving motor skills). Some studies have shown that other cognitive strategies also increase the strength and muscular resistance in healthy people by the enhancement of the performance during dynamic tasks. Mental training sessions may be primordial to improving muscle strength in different subjects. The aim of this study was to systematically review and meta-analiyze studies that assessed whether mental practice is effective in improving muscular strength...
2015: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/26533568/a-network-metanalysis-comparing-the-efficacy-of-biologics-for-the-treatment-of-early-rheumatoid-arthritis
#16
E Bizzi, L Petrella, D Integlia, A Migliore
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26376359/-safety-of-human-papillomavirus-6-11-16-and-18-recombinant-systematic-review-and-meta-analysis
#17
Pedro Luiz Spinelli Coelho, Gustavo Lacerda da Silva Calestini, Fernando Salgueiro Alvo, Jefferson Michel de Moura Freitas, Paula Marcela Vilela Castro, Tulio Konstantyner
OBJECTIVE: To identify and quantify the adverse effects associated with the recombinant human papillomavirus (types 6, 11, 16 and 18) vaccine in adolescents. DATA SOURCE: Systematic review of randomized clinical trials from PubMed, SciELO and Lilacs databases. Articles investigating the safety of the vaccine in subjects under 18 years and comparing the recombinant human papillomavirus types 6, 11, 16 and 18 vaccine with a control group were included. Meta-analyses were performed for the outcomes of pain, erythema, swelling and fever, using clinical trials with maximum Jadad score...
December 2015: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/26245272/efficacy-and-safety-of-over-the-counter-whitening-strips-as-compared-to-home-whitening-with-10-carbamide-peroxide-gel-systematic-review-of-rcts-and-metanalysis
#18
Carla Regina Serraglio, Luana Zanella, Karine Battestin Dalla-Vecchia, Sinval Adalberto Rodrigues-Junior
OBJECTIVES: The study aims to compare the efficacy and safety of over-the-counter whitestrips with the American Dental Association (ADA)-recommended home-whitening using the 10 % carbamide peroxide gel. MATERIALS AND METHODS: Randomized controlled trials (RCTs) comparing the clinical efficacy and safety of the whitestrips with the 10 % carbamide peroxide (10 % CP) gel applied on tray for tooth whitening in adults were searched at PubMed and Cochrane Central Register of Controlled Trials databases and selected up to October 2014...
January 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26226708/women-have-right-ventricular-infarction-more-frequently-than-men
#19
Slobodan Obradovic, Boris Dzudovic, Ivica Djuric, Zoran Jovic, Nemanja Djenic
OBJECTIVE: The objective of the study was to determine whether women significantly have more frequently right ventricular infarction than men. METHODS: The study population consisted of consecutive patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous intervention. The following criteria were used for the diagnosis of right ventricular infarction: ST-segment elevation in one of the right precordial leads V4R-V6R for equal or more than 1 mm together with ST-segment elevation in at least two contiguous inferior leads...
June 2015: Acta Cardiologica
https://www.readbyqxmd.com/read/26209782/extracorporeal-shock-wave-therapy-eswt-for-the-treatment-of-cellulite-a-current-metaanalysis
#20
REVIEW
Karsten Knobloch, Robert Kraemer
BACKGROUND: The aim of this metaanalysis was to investigate the effectiveness of extracorporeal shock wave therapy (ESWT) in cellulite. METHODS: Electronic databases (such as Ovid MEDLINE, Scopus and Ovid) as well as reference lists of the available studies were evaluated in June 2015 by two expert examiners. Assessment of each study's methodological quality was performed with the help of the published quality index tool by Downs and Black. RESULTS: This metanalysis included a total of eleven clinical trials on the effects of ESWT on cellulite with a total of 297 included females...
December 2015: International Journal of Surgery
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