keyword
https://read.qxmd.com/read/38497865/therapeutic-potential-of-ramipril-losartan-and-spironolactone-against-sepsis-associated-liver-tissue-injury-induced-by-cecal-ligation-and-puncture-in-rats
#1
JOURNAL ARTICLE
A Al-Kadi, M El-Daly, N F G El-Tahawy, O Fahmi, A B Abdel-Naim, M M A Khalifa, A F Ahmed
OBJECTIVE: Sepsis-associated liver injury is responsible for the high morbidity and mortality rates seen with septic shock. Activation of the renin-angiotensin-aldosterone system (RAAS) is an essential counteractive mechanism during the hypotensive phase of sepsis; however, excessive activation is associated with exaggerated pro-oxidant and inflammatory response, which aggravates organ damage. This study aimed to evaluate the effect of RAAS inhibition on sepsis-induced liver damage. MATERIALS AND METHODS: The cecal ligation and puncture (CLP) model was employed as a model of sepsis...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38473157/self-reported-utilization-of-international-acvim-consensus-guidelines-and-the-latest-clinical-trial-results-on-the-treatment-of-dogs-with-various-stages-of-myxomatous-mitral-valve-degeneration-a-survey-among-veterinary-practitioners
#2
JOURNAL ARTICLE
Marie D B van Staveren, Esther Muis, Viktor Szatmári
BACKGROUND: Myxomatous mitral valve degeneration is the most common canine heart disease. Several clinical trials have investigated various treatments. The latest recommendations are published in the ACVIM consensus guidelines (2019). Our study aimed to investigate how closely veterinary practitioners apply the treatment recommendations of these guidelines and the latest clinical trials. METHODS: An online survey was sent to Dutch and Belgian veterinary practices via digital channels...
February 29, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38465112/retrospective-analysis-of-potential-adverse-drug-interactions-in-the-drugs-prescribed-to-the-elderly-at-a-tertiary-health-care-center-in-raipur-chhattisgarh-central-india
#3
JOURNAL ARTICLE
Yazhini Rajendran, Yogendra Keche, Nitin R Gaikwad, Suryaprakash Dhaneria
Background The elderly population differs from adults in having various physiological changes and multiple diseases, which demand the use of multiple medications. The practice of polypharmacy in the elderly leads to numerous harmful effects like adverse drug reactions, adverse drug-drug interactions (DDIs), poor compliance, etc. Methodology This study collected 295 case files of elderly patients retrospectively in the Departments of General Medicine, Cardiology and Nephrology after obtaining Institute Ethics Committee approval to look for the potential adverse DDIs with their severity according to the clinical significance...
February 2024: Curēus
https://read.qxmd.com/read/38418004/angiotensin-receptor-neprilysin-inhibition-in-patients-with-stemi%C3%A2-vs%C3%A2-nstemi
#4
RANDOMIZED CONTROLLED TRIAL
Douglas L Mann, Johny Nicolas, Brian Claggett, Zi Michael Miao, Christopher B Granger, Prafulla Kerkar, Lars Køber, Eldrin F Lewis, John J V McMurray, Aldo P Maggioni, Julio Núñez, Mpiko Ntsekhe, Jean-Lucien Rouleau, David Sim, Scott D Solomon, Philippe Gabriel Steg, Peter van der Meer, Eugene Braunwald, Marc A Pfeffer, Roxana Mehran
BACKGROUND: Patients who sustain an acute myocardial infarction (AMI), including ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI), remain at high risk for heart failure (HF), coronary events, and death. Angiotensin-converting enzyme inhibitors have been shown to significantly decrease the risk for cardiovascular events in both STEMI and NSTEMI patients. OBJECTIVES: The objectives were to determine whether angiotensin-receptor blockade and neprilysin inhibition with sacubitril/valsartan, compared with ramipril, has impact on reducing cardiovascular events according to the type of AMI...
March 5, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38332533/renal-drug-dosage-adjustments-and-adverse-drug-events-in-patients-with-chronic-kidney-disease-admitted-to-the-hospital-a-cross-sectional-study
#5
JOURNAL ARTICLE
Zuzana Očovská, Jana Procházková, Martina Maříková, Jiří Vlček
BACKGROUND: The study aimed to evaluate the agreement of prescribed drug dosages with renal dosing recommendations and describe adverse drug events (ADEs) contributing to hospital admissions of patients with chronic kidney disease (CKD). METHODS: This cross-sectional study focused on CKD patients admitted to University Hospital Hradec Králové, with an estimated glomerular filtration rate below 60 ml/min. The necessity for renal dosage adjustments was determined using the Summary of Product Characteristics (SmPC)...
February 8, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38275965/color-flu-fluorescent-reporter-influenza-a-viruses-allow-for-in-vivo-studies-of-innate-immune-function-in-zebrafish
#6
JOURNAL ARTICLE
Brandy-Lee Soos, Alec Ballinger, Mykayla Weinstein, Haley Foreman, Julianna Grampone, Samuel Weafer, Connor Aylesworth, Benjamin L King
Influenza virus infection can cause severe respiratory disease and is estimated to cause millions of illnesses annually. Studies on the contribution of the innate immune response to influenza A virus (IAV) to viral pathogenesis may yield new antiviral strategies. Zebrafish larvae are useful models for studying the innate immune response to pathogens, including IAV, in vivo. Here, we demonstrate how Color-flu, four fluorescent IAV strains originally developed for mice, can be used to study the host response to infection by simultaneously monitoring infected cells, neutrophils, and macrophages in vivo...
January 20, 2024: Viruses
https://read.qxmd.com/read/38252738/pulmonary-congestion-and-left-ventricular-dysfunction-after-myocardial-infarction-insights-from-the-paradise-mi-trial
#7
JOURNAL ARTICLE
Mark C Petrie, Jean L Rouleau, Brian Claggett, Karola Jering, Peter van der Meer, Lars Køber, Zi Michael Miao, Eldrin Lewis, Christopher Granger, Carmine G De Pasqulae, Douglas Mann, Philippe Gabriel Steg, Aldo Maggioni, Offer Amir, Marty Lefkowitz, Eugene Braunwald, Scott D Solomon, John J V McMurray, Marc A Pfeffer
No abstract text is available yet for this article.
January 23, 2024: Circulation
https://read.qxmd.com/read/38236629/characterizing-and-comparing-adverse-drug-events-documented-in-2-spontaneous-reporting-systems-in-the-lower-mainland-of-british-columbia-canada-retrospective-observational-study
#8
JOURNAL ARTICLE
Erica Y Lau, Amber Cragg, Serena S Small, Katherine Butcher, Corinne M Hohl
BACKGROUND: Robust adverse drug event (ADE) reporting systems are crucial to monitor and identify drug safety signals, but the quantity and type of ADEs captured may vary by system characteristics. OBJECTIVE: We compared ADEs reported in 2 different reporting systems in the same jurisdictions, the Patient Safety and Learning System-Adverse Drug Reaction (PSLS-ADR) and ActionADE, to understand report variation. METHODS: This retrospective observational study analyzed reports entered into PSLS-ADR and ActionADE systems between December 1, 2019, and December 31, 2022...
January 18, 2024: JMIR Human Factors
https://read.qxmd.com/read/38235056/the-association-between-warfarin-usage-and-international-normalized-ratio-increase-systematic-analysis-of-fda-adverse-event-reporting-system-faers
#9
JOURNAL ARTICLE
Robert Morris, Megan Todd, Nicole Zapata Aponte, Milagros Salcedo, Matthew Bruckner, Alfredo Suarez Garcia, Rachel Webb, Kun Bu, Weiru Han, Feng Cheng
INTRODUCTION: Elevated international normalized ratio (INR) has been commonly reported as an adverse drug event (ADE) for patients taking warfarin for anticoagulant therapy. AIM: The purpose of this study was to determine the association between increased INR and the usage of warfarin by using the pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS). METHODS: The ADEs in patients who took warfarin ( N = 77,010) were analyzed using FAERS data...
October 2023: The journal of cardiovascular aging
https://read.qxmd.com/read/38228033/effects-of-telmisartan-on-metabolic-syndrome-components-a-comprehensive-review
#10
REVIEW
Mohsen Imenshahidi, Ali Roohbakhsh, Hossein Hosseinzadeh
Telmisartan is an antagonist of the angiotensin II receptor used in the management of hypertension (alone or in combination with other antihypertensive agents. It belongs to the drug class of angiotensin II receptor blockers (ARBs). Among drugs of this class, telmisartan shows particular pharmacologic properties, including a longer half-life than any other angiotensin II receptor blockers that bring higher and persistent antihypertensive activity. In hypertensive patients, telmisartan has superior efficacy than other antihypertensive drugs (losartan, valsartan, ramipril, atenolol, and perindopril) in controlling blood pressure, especially towards the end of the dosing interval...
February 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38218697/protective-effect-of-ramipril-against-oxidant-and-proinflammatory-cytokine-damage-induced-by-ischemia-reperfusion-in-ovarian-tissue-in-rats
#11
JOURNAL ARTICLE
Pasa Ulug, Umit Nayki, Renad Mammadov, Seval Bulut, Tugba Bal Tastan, Taha Abdulkadir Coban, Halis Suleyman
BACKGROUND: It is known that the increase in oxidants and proinflammatory cytokines, as well as the decrease in antioxidants, play a role in ovarian ischemia-reperfusion (I/R) injury. The antioxidant and anti-inflammatory properties of ramipril have been studied in various diseases. This study aims to investigate the effect of ramipril on I/R-induced ovarian damage in rats. METHODS: Rats were divided into healthy (HG), sham (SG), ovary I/R (OIR), and ramipril + ovary I/R (ROIR) groups (n = 6/each group)...
January 12, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38197151/clinical-trial-design-for-assessing-hypertension-medications-are-critical-circadian-chronopharmacological-principles-being-taking-into-account
#12
JOURNAL ARTICLE
Ramón C Hermida, Michael H Smolensky, Artemio Mojón, José R Fernández
INTRODUCTION: Clinical hypertension trials typically rely on homeostatic principles, including single time-of-day office blood pressure (BP) measurements (OBPM), rather than circadian chronopharmacological principles, including ambulatory monitoring (ABPM) done around-the-clock to derive the asleep systolic BP (SBP) mean and sleep-time relative SBP decline - jointly the strongest prognosticators of cardiovascular disease (CVD) risk and true definition of hypertension - to qualify participants and assess outcomes...
January 10, 2024: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/38159824/evaluation-of-the-efficacy-of-hydro-alcoholic-extract-of-evolvulus-alsinoides-l-for-the-treatment-of-primary-hypertension-a-randomized-controlled-trial
#13
JOURNAL ARTICLE
Mantasha Binth Siraj, Asim Ali Khan, Umar Jahangir, Ayshah Hashimi, Yasmeen Ahmad, Nazim Husain
ETHNOPHARMACOLOGICAL RELEVANCE: Evolvulus alsinoides L. (Sankhaholi) has been traditionally used in Unani (Greco-Arabic) medicine to treat diverse cardiovascular disorders. Notably, preclinical and clinical investigations have substantiated its remarkable potential as an antihypertensive agent. AIM OF THE STUDY: The aim of this study was to compare the efficacy of hydroalcoholic extract of Evolvulus alsinoides L. and ramipril in treating hypertension using a higher dose of the test drug within the recommended limit...
December 28, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38137440/blockade-of-inflammatory-markers-attenuates-cardiac-remodeling-and-fibrosis-in-rats-with-supravalvular-aortic-stenosis
#14
JOURNAL ARTICLE
Francine Duchatsch, Danyelle S Miotto, Lidieli P Tardelli, Thiago J Dionísio, Dijon S Campos, Carlos F Santos, Katashi Okoshi, Sandra L Amaral
Since cardiac inflammation has been considered an important mechanism involved in heart failure, an anti-inflammatory treatment could control cardiac inflammation and mitigate the worsening of cardiac remodeling. This study evaluated the effects of dexamethasone (DEX) and ramipril treatment on inflammation and cardiac fibrosis in an experimental model of heart failure induced by supravalvular aortic stenosis. Wistar rats (21d) were submitted to an aortic stenosis (AS) protocol. After 21 weeks, an echocardiogram and a maximal exercise test were performed, and after 24 weeks, rats were treated with DEX, ramipril or saline for 14d...
December 5, 2023: Biomedicines
https://read.qxmd.com/read/38129319/ramipril-therapy-in-integrin-%C3%AE-1-null-autosomal-recessive-alport-mice-triples-lifespan-mechanistic-clues-from-rna-seq-analysis
#15
JOURNAL ARTICLE
Jacob Madison, Kevin Wilhelm, Daniel T Meehan, Michael Anne Gratton, Denise Vosik, Gina Samuelson, Megan Ott, John Fascianella, Noa Nelson, Dominic Cosgrove
The standard of care for patients with Alport syndrome (AS) is angiotensin-converting enzyme (ACE) inhibitors. In autosomal recessive Alport (ARAS) mice, ACE inhibitors double lifespan. We previously showed that deletion of Itga1 in Alport mice [double-knockout (DKO) mice] increased lifespan by 50%. This effect seemed dependent on the prevention of laminin 211-mediated podocyte injury. Here, we treated DKO mice with vehicle or ramipril starting at 4 weeks of age. Proteinuria and glomerular filtration rates were measured at 5-week intervals...
March 2024: Journal of Pathology
https://read.qxmd.com/read/38112376/comprehensive-cardiovascular-therapy-in-emery-dreifuss-muscular-dystrophy-a-case-report
#16
JOURNAL ARTICLE
Taras V Chendey, Mykola V Rishko, Victoria I Chendey
A 25-year-old male with known EDMD was referred for the cardiology consultation due to symptoms of heart failure. Echocardiography showed decrease left ventricular ejection fraction (LVEF) and therapy with ramipril, torsemide and rivaroxaban was initiated. Despite initial improvement, the patient later developed presyncope, bradycardia, irregular heartbeat and worsening of dyspnea. Therefore, implantation of resynchronization pacemaker with the function of implantable cardioverter-defibrillator (CRT-D/P) was performed...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38093823/a-case-report-of-myocardial-infarction-in-a-young-transgender-man-with-testosterone-therapy-raising-awareness-on-healthcare-issues-in-the-transgender-community-and-a-call-for-further-research
#17
Paul J Connelly, Joanna Osmanska, Matthew M Y Lee, Christian Delles, Margaret B McEntegart, John Byrne
BACKGROUND: People who are transgender may utilize masculinizing or feminizing gender-affirming hormonal therapy. Testosterone and oestrogen receptors are expressed throughout the cardiovascular system, yet the effects of these therapies on cardiovascular risk and outcomes are largely unknown. We report the case of a young transgender man with no discernible cardiovascular risk factors presenting with an acute coronary syndrome. CASE SUMMARY: A 31-year-old transgender man utilizing intramuscular testosterone masculinizing gender-affirming hormonal therapy presented with central chest pain radiating to the left arm...
December 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/38078460/the-association-between-ace-inhibitors-and-psoriasis-based-on-the-drug-targeted-mendelian-randomization-and-real-world-pharmacovigilance-analyses
#18
JOURNAL ARTICLE
Qiubai Jin, Feihong Ren, Ping Song
BACKGROUND: Although a growing number of observational studies suggest that angiotensin-converting enzyme inhibitors (ACEIs) intake may be a risk factor for psoriasis, evidence is still insufficient to draw definitive conclusions. RESEARCH DESIGN AND METHODS: Drug-targeted Mendelian randomization (DTMR) was used to analyze the causality between genetic proxied ACEIs and psoriasis. Furthermore, we performed a disproportionality analysis based on the FDA adverse event reporting system (FAERS) database to identify more suspicious subclasses of ACEIs...
December 11, 2023: Expert Review of Clinical Pharmacology
https://read.qxmd.com/read/38069366/cardioprotective-and-antifibrotic-effects-of-low-dose-renin-angiotensin-aldosterone-system-inhibitors-in-type-1-diabetic-rat-model
#19
JOURNAL ARTICLE
Dora B Balogh, Agnes Molnar, Arianna Degi, Akos Toth, Lilla Lenart, Adar Saeed, Adrienn Barczi, Attila J Szabo, Laszlo J Wagner, Gyorgy Reusz, Andrea Fekete
Diabetic cardiovascular complications are associated with up to 50% mortality, and current therapies are not effective enough. Renin-angiotensin-aldosterone system inhibitors (RAASis) are the standard of care for diabetic patients with hypertension and albuminuria. Based on our previous studies reporting the renoprotective effects of low-dose RAASis, here, we hypothesized that low-dose RAASi treatment has cardioprotective and antifibrotic benefits in type 1 diabetes mellitus (T1DM). After five weeks of T1DM, adult male Wistar rats received low doses of ramipril, losartan, or eplerenone for two weeks...
December 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38032920/interactive-effect-of-oral-anti-hyperglycaemic-or-anti-hypertensive-drugs-on-the-inhibitory-and-bactericidal-activity-of-first-line-anti-tb-drugs-against-m-tuberculosis
#20
JOURNAL ARTICLE
Priyanka Trivedi, Vinita Chaturvedi
Co-existence of life style disorders, like, Diabetes or Hypertension, increases risk of, treatment failure, deaths and developing drug-resistant TB. Concomitant administration of drugs to treat dual/multi-morbidities may alter their effectiveness, in additive/synergistic or adverse/antagonistic manner. We evaluated interactive effect of 7 anti-hyperglycaemic (HG) and 6 anti-hypertensive (HT) drugs on the inhibitory (MICs) and bactericidal (% killing of intracellular bacilli) activities of anti-TB drugs, Isoniazid (INH), Rifampicin (RFM), Ethambutol (EMB) and Streptomycin (STR) against M...
2023: PloS One
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