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https://www.readbyqxmd.com/read/28718346/effect-of-desvenlafaxine-50-mg-and-100-mg-on-energy-and-lassitude-in-patients-with-major-depressive-disorder-a-pooled-analysis
#1
Raymond W Lam, Dalia B Wajsbrot, Ellen Meier, Elizabeth Pappadopulos, Joan A Mackell, Matthieu Boucher
Nine randomized, double-blind, placebo-controlled studies of major depressive disorder were pooled to evaluate the effects of desvenlafaxine 50- and 100-mg/d on energy and lassitude in adults with major depressive disorder ( n=4279). Changes from baseline to endpoint in 17-item Hamilton Rating Scale for Depression (HAM-D17) Work and Activities, Retardation, and Somatic Symptoms General items, HAM-D17 psychomotor retardation factor, and Montgomery-Åsberg Depression Rating Scale Lassitude item were analyzed with a mixed model for repeated measures analysis of variance...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28718334/the-preclinical-discovery-and-development-of-brexpiprazole-for-the-treatment-of-major-depressive-disorder
#2
Awais Aftab, Keming Gao
Brexpiprazole is the most recently approved second-generation antipsychotic, which is used as adjunctive therapy to antidepressants for treating major depressive disorder (MDD) with inadequate response. Brexpiprazole shares pharmacological similarities with other second-generation antipsychotics, especially aripiprazole. Area covered: This review provides a detailed overview of the pre-clinical studies of brexpiprazole, followed by a summary of its clinical studies, and a comparison with other antipsychotics in MDD...
July 18, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28718181/erythropoietin-for-cognitive-deficits-associated-with-schizophrenia-bipolar-disorder-and-major-depression-a-systematic-review
#3
Xian-Bin Li, Wei Zheng, Yu-Ping Ning, Dong-Bin Cai, Xin-Hu Yang, Gabor S Ungvari, Chee H Ng, Chuan-Yue Wang, Yu-Tao Xiang
Introduction The purpose of this study is to systematically review the efficacy and safety of adjunctive erythropoietin (EPO) in treating cognitive deficits associated with schizophrenia, bipolar disorder, and major depression based on randomized controlled trials (RCTs). Methods Two evaluators independently and systematically searched and selected studies, extracted data, and conducted quality assessment. Results Four RCTs with 144 patients (71 in the EPO group and 73 in the placebo group) met the study entry criteria...
July 17, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28717197/subcortical-volume-and-white-matter-integrity-abnormalities-in-major-depressive-disorder-findings-from-uk-biobank-imaging-data
#4
Xueyi Shen, Lianne M Reus, Simon R Cox, Mark J Adams, David C Liewald, Mark E Bastin, Daniel J Smith, Ian J Deary, Heather C Whalley, Andrew M McIntosh
Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, scanners and imaging sequences may, however, obscure further anatomical differences. In this study, we tested for differences in subcortical grey matter volume (n = 1157) and white matter integrity (n = 1089) between depressed individuals and controls in the subset of 8590 UK Biobank Imaging study participants who had undergone depression assessments...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716225/regional-cerebral-glucose-metabolism-in-systemic-lupus-erythematosus-patients-with-major-depressive-disorder
#5
Tomoyuki Saito, Maasa Tamura, Yuhei Chiba, Omi Katsuse, Akira Suda, Ayuko Kamada, Takahiro Ikura, Kie Abe, Matsuyoshi Ogawa, Kaoru Minegishi, Ryusuke Yoshimi, Yohei Kirino, Atsushi Ihata, Yoshio Hirayasu
OBJECTIVES: Depression is frequently observed in patients with systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) patients often exhibit cerebral hypometabolism, but the association between cerebral metabolism and depression remains unclear. To elucidate the features of cerebral metabolism in SLE patients with depression, we performed brain 18F-fluoro-d-glucose positron emission tomography (FDG-PET) on SLE patients with and without major depressive disorder. METHODS: We performed brain FDG-PET on 20 SLE subjects (5 male, 15 female)...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28716128/tobacco-dependence-among-people-with-mental-illness-a-facility-based-cross-sectional-study-from-southwest-ethiopia
#6
Zemenay Molla, Lamesa Dube, Wolfgang Krahl, Matiwos Soboka
BACKGROUND: Tobacco smoking is a health care issue in developed as well as in developing countries. Tobacco smoking among people with mental illness is significantly higher than in the general population. Tobacco smoking has negative effects on physical, mental and financial well-being of people with mental illness but little is known about tobacco dependence among mental health service users in sub-Saharan African countries, including Ethiopia. Therefore, this study attempted to assess the prevalence of tobacco dependence and associated factors among mental health service users at Jimma University teaching hospital...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28715705/investigating-the-relationship-between-iron-and-depression
#7
Natalie T Mills, Robert Maier, John B Whitfield, Margaret J Wright, Lucia Colodro-Conde, Enda M Byrne, James G Scott, Gerard J Byrne, Narelle K Hansell, Anna A E Vinkhuyzen, Baptiste CouvyDuchesne, Grant W Montgomery, Anjali K Henders, Nicholas G Martin, Naomi R Wray, Beben Benyamin
Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and depressive symptoms. Data were available from ongoing studies at QIMR Berghofer Medical Research Institute (QIMRB), including twin adolescents (mean age 15.1 years, standard deviation (SD) 3.2 years), and twin adults (mean age 23.2 years, SD 2.2 years)...
July 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28714778/how-clients-change-emotion-with-emotion-a-programme-of-research-on-emotional-processing
#8
Antonio Pascual-Leone
This paper reviews a body of research that has examined Pascual-Leone and Greenberg's sequential model of emotional processing or used its accompanying measure (the Classification of Affective Meaning States). Research from 24 studies using a plurality of methods examined process-outcome relationships from micro to macro levels of observation and builds support for emotional transformation as a possible causal mechanism of change in psychotherapy. A pooled sample of 310 clinical and 130 sub-clinical cases have been studied, reflecting the process of 7 different treatment approaches in addressing over 5 different presenting clinical problems (including depression, anxiety, relational trauma, and personality disorders)...
July 17, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28714722/pilot-testing-the-daily-activities-list-for-inmates-dali-item-evaluation-and-content-validity
#9
Philip R Magaletta, Rokas Perskaudas, Christina J Connors, Marc W Patry, Jarrod Reisweber, Alix McLearen
Scheduling enjoyable daily activities is a Cognitive Behavioral Therapy intervention used in the treatment of depression and substance abuse disorders that are prevalent disorders among inmates. To effectively use this intervention with inmates, an activities list with items ecologically sensitive to the correctional setting needs to be created. The purpose of this study was to develop and evaluate items; thus, establishing a content valid Daily Activities List for Inmates (DALI). Fifteen corrections professionals representing a wide range of disciplines and managerial backgrounds served as subject matter experts (SMEs)...
July 17, 2017: Psychological Services
https://www.readbyqxmd.com/read/28714606/treating-depression-during-pregnancy-are-we-asking-the-right-questions
#10
REVIEW
Cara Angelotta, Katherine L Wisner
BACKGROUND: Major depressive disorder (MDD) is a common complication of pregnancy. Once the diagnosis of MDD is made, the physician must assist the pregnant woman in developing a treatment plan. METHODS: In considering antidepressants, the benefit of medication treatment for maternal disease control must be balanced against the risk of the drug to the developing embryo-fetus. This is an individualized decision depending on the disease characteristics, likelihood of maternal depression response, probability of adverse fetal effects, and patient characteristics and values...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28714605/epigenetic-alterations-and-prenatal-maternal-depression
#11
REVIEW
Zsofia Nemoda, Moshe Szyf
Major depressive disorder of the mother affects 6 to 17% of pregnancies worldwide and can lead to negative outcomes, such as preterm delivery and later mental health problems of the child. It has been proposed that developmental programming has long-lasting effects in the offspring that might be mediated by epigenetic mechanisms, such as DNA methylation. Altered stress regulation or impaired immunological function of the mother can potentially affect DNA methylation processes of the fetus, changing gene expression levels in utero...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28714580/differential-failure-to-deactivate-the-default-mode-network-in-unipolar-and-bipolar-depression
#12
Elena Rodríguez-Cano, Silvia Alonso-Lana, Salvador Sarró, Paloma Fernández-Corcuera, José M Goikolea, Eduard Vieta, Teresa Maristany, Raymond Salvador, Peter J McKenna, Edith Pomarol-Clotet
OBJECTIVES: Neuroimaging studies have revealed evidence of brain functional abnormalities in bipolar depressive disorder (BDD) and major depressive disorder (MDD). However, few studies to date have compared these two mood disorders directly. METHODS: Matched groups of 26 BDD type I patients, 26 MDD patients and 26 healthy controls underwent functional magnetic resonance imaging (fMRI) while performing the n-back working memory task. A whole-brain ANOVA was used to compare the three groups and clusters of significant difference were examined further using region-of-interest (ROI) analysis...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28713688/childhood-trauma-and-factors-associated-with-depression-among-inpatients-with-cardiovascular-disease
#13
Felipe José Nascimento Barreto, Frederico Duarte Garcia, Paulo Henrique Teixeira Prado, Paulo Marcos Brasil Rocha, Nádia Souza Las Casas, Felipe Barbosa Vallt, Humberto Correa, Maila Castro Lourenço Neves
AIM: To identify factors associated with depressive symptoms among inpatients with cardiovascular disease (CVD). METHODS: This is a cross-sectional study performed in a subsample of a large cross-sectional research that investigated affective disorders and suicide behaviour among inpatients hospitalized in non-surgical wards of the University Hospital of the Federal University of Minas Gerais from November 2013 to October 2015. Sociodemographic and clinical data were obtained through a structured interview and medical record review...
June 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28712878/antidepressants-are-cytotoxic-to-rat-primary-blood-brain-barrier-endothelial-cells-at-high-therapeutic-concentrations
#14
Ekramy Elmorsy, Ayat Al-Ghafari, Fahd M Almutairi, Amal Misbah Aggour, Wayne G Carter
Antidepressants are commonly employed for the treatment of major depressive disorders and other psychiatric conditions. We investigated the relatively acute cytotoxic effects of three commonly prescribed antidepressants: fluoxetine, sertraline, and clomipramine on rat primary blood brain barrier endothelial cells over a concentration range of 0.1-100μM. At therapeutic concentrations (0.1μM) no significant cytotoxicity was observed after 4, 24, or 48h. At high therapeutic to overdose concentrations (1-100μM), antidepressants reduced cell viability in proportion to their concentration and exposure duration...
July 13, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28712429/the-association-between-multiple-chemical-sensitivity-and-mental-illness-evidence-from-a-nationally-representative-sample-of-canadians
#15
Dylan Johnson, Ian Colman
OBJECTIVE: The goal of the present study was to investigate the association between multiple chemical sensitivity (MCS) and major depressive disorder (MDD), generalized anxiety disorder (GAD), MDD and GAD comorbidity (MDD+GAD), severe distress, and positive mental wellbeing. METHODS: This cross-sectional investigation was carried out using the 2012 Canadian Community Health Survey - Mental Health Component. The study population consisted of 21,977 individuals aged 20 and older, from Canada's ten provinces...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712427/depression-inflammation-and-epidermal-growth-factor-receptor-egfr-status-in-metastatic-non-small-cell-lung-cancer-a-pilot-study
#16
Jamie M Jacobs, Lara Traeger, Justin Eusebio, Naomi M Simon, Lecia V Sequist, Joseph A Greer, Jennifer S Temel, William F Pirl
OBJECTIVE: Patients with stage IV non-small cell lung cancer (NSCLC) have high risk for depressive symptoms and major depressive disorder (MDD); however, those with epidermal growth factor receptor (EGFR) mutations may have decreased risk. The biological underpinning of this relationship is unknown. We examined differences in depression severity and MDD in patients with newly diagnosed stage IV NSCLC based on EGFR mutation status, and examined proinflammatory cytokines and growth factors known to play a role in cancer progression and depression...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712425/telomere-length-is-inversely-correlated-with-urinary-stress-hormone-levels-in-healthy-controls-but-not-in-un-medicated-depressed-individuals-preliminary-findings
#17
Brittany Fair, Synthia H Mellon, Elissa S Epel, Jue Lin, Dóra Révész, Josine E Verhoeven, Brenda W Penninx, Victor I Reus, Rebecca Rosser, Christina M Hough, Laura Mahan, Heather M Burke, Elizabeth H Blackburn, Owen M Wolkowitz
OBJECTIVE: Leukocyte telomere length (LTL) is a biomarker of cellular aging affected by chronic stress. The relationship of LTL to the stress hormones, cortisol and catecholamines, is unclear, as are possible differences between healthy controls (HC) and individuals with Major Depressive Disorder (MDD). This small pilot study is the first to examine the relationship between cortisol, catecholamines and LTL specifically in un-medicated MDD in comparison with HC. METHODS: Participants included 16 un-medicated MDD subjects and 15 HC for assay of LTL, 12-hour overnight urinary free cortisol and catecholamine levels...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28711814/problem-alcohol-use-and-healthcare-utilization-among-persons-with-cannabis-use-disorder-in-the-united-states
#18
William S John, Li-Tzy Wu
BACKGROUND: The emergency department (ED) and hospital settings represent crucial opportunities for engaging treatment for cannabis use disorder (CUD). Thus, there is a need to identify factors associated with healthcare utilization among persons with CUD to improve screening and intervention approaches. Problematic alcohol use may be a salient risk factor. METHODS: Using data from the 2005-2013 National Surveys on Drug Use and Health, we determined factors, including different patterns of alcohol use, associated with past-year ED admission and inpatient hospitalization among persons aged 12 years or older meeting criteria for CUD in the past year (N=16,757)...
June 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28711797/symptom-severity-and-disability-in-psychiatric-disorders-the-u-s-collaborative-psychiatric-epidemiology-survey
#19
R García-Velázquez, M Jokela, T H Rosenström
BACKGROUND: While most psychiatric diagnoses are based on simple counts of symptoms, some symptoms may be sign of a more severe mental syndrome than others. This calls for validated estimates of the relative severity specific symptoms imply within a disorder. We focused on four diagnostic disorders: Manic Episode (ME), Major Depressive Episode (MDE), Post-traumatic Stress Disorder (PTSD) and Generalized Anxiety Disorder (GAD). Symptom-specific severity parameters were estimated, and validated by examining their association with levels of self-reported disability in daily activities over and above the number of symptoms...
July 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711621/length-of-axons-expressing-the-serotonin-transporter-in-orbitofrontal-cortex-is-lower-with-age-in-depression
#20
Grazyna Rajkowska, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R Albert, Mireille Daigle, Jose J Miguel-Hidalgo, Mark C Austin, Randy D Blakely, David C Steffens, Craig A Stockmeier
Studies of major depressive disorder (MDD) in postmortem brain tissue report enhanced binding to inhibitory serotonin-1A autoreceptors in midbrain dorsal raphe and reductions in length of axons expressing the serotonin transporter (SERT) in dorsolateral prefrontal cortex. The length density of axons expressing SERT in the orbitofrontal cortex (OFC) was determined in 18 subjects with MDD and 17 age-matched control subjects. A monoclonal antibody was used to immunohistochemically label the SERT in fixed sections of OFC...
July 12, 2017: Neuroscience
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