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Major depressive disorder

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https://www.readbyqxmd.com/read/29166674/unpredictable-chronic-mild-stress-differentially-impairs-social-and-contextual-discrimination-learning-in-two-inbred-mouse-strains
#1
Michiel van Boxelaere, Jason Clements, Patrick Callaerts, Rudi D'Hooge, Zsuzsanna Callaerts-Vegh
Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits...
2017: PloS One
https://www.readbyqxmd.com/read/29166552/vortioxetine-versus-placebo-in-major-depressive-disorder-comorbid-with-social-anxiety-disorder
#2
Michael R Liebowitz, Jason Careri, Kyra Blatt, Ann Draine, Junko Morita, Melissa Moran, Rita Hanover
BACKGROUND: Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) are highly comorbid, yet the combined condition has not been subject to any placebo-controlled treatment trials. This study reports a trial of vortioxetine, an antidepressant that has also shown benefit in Generalized Anxiety Disorder (GAD), in patients meeting DSM-5 criteria for both MDD and SAD. METHODS: The study was a 12-week double-blind, placebo-controlled comparison of vortioxetine 10-20 mg/day or placebo administered on a 1:1 ratio...
November 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29164903/do-mental-disorders-moderate-the-association-between-diabetes-status-and-alcohol-consumption
#3
Randa Elgendy, Sonya S Deschênes, Rachel J Burns, Norbert Schmitz
Although heavy alcohol consumption is associated with diabetes-related complications, little is known about patterns of alcohol use among people with diabetes. Moreover, heavy drinking is more common among individuals with major depressive disorder (MDD), bipolar disorder (BD), and generalized anxiety disorder (GAD) than in the general population, and these disorders are often comorbid with diabetes. The present study tested the hypothesis that mental disorders moderate the association between diabetes status and alcohol consumption...
November 22, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29164439/brief-report-major-depressive-disorder-with-psychotic-features-in-williams-syndrome-a-case-series
#4
Francisca Valdes, Christopher J Keary, Jennifer E Mullett, Michelle L Palumbo, Jessica L Waxler, Barbara R Pober, Christopher J McDougle
Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29164354/associations-between-major-depressive-episode-methamphetamine-use-disorder-severity-and-engagement-in-sexual-risk-taking-among-methamphetamine-using-men-who-have-sex-with-men
#5
Jesse B Fletcher, Dallas Swendeman, Cathy J Reback
Depression and methamphetamine use have been associated with increased sexual risk-taking among men who have sex with men (MSM). This study estimated associations between current major depressive episode and/or methamphetamine use disorder and engagement in condomless anal intercourse (CAI). From March 2014 thru January 2016, 286 methamphetamine-using MSM were enrolled into a RCT to reduce methamphetamine use and sexual risk-taking. Analyses revealed that current major depressive episode was associated with a 92% increase in the rate of engagement in CAI with casual male partners (IRR 1...
November 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29163870/transdiagnostic-culturally-adapted-cbt-with-farsi-speaking-refugees-a-pilot-study
#6
Schahryar Kananian, Sarah Ayoughi, Arieja Farugie, Devon Hinton, Ulrich Stangier
Background: Approximately half of all asylum seekers suffer from trauma-related disorders requiring treatment, among them Posttraumatic Stress Disorder (PTSD), depression, anxiety, and somatic symptoms. There is a lack of easily accessible, low-threshold treatments taking the cultural background into account. Culturally Adapted CBT (CA CBT) is a well evaluated, transdiagnostic group intervention for refugees, using psychoeducation, meditation, and Yoga-like exercises. Objective: An uncontrolled pilot study with male Farsi-speaking refugees from Afghanistan and Iran was conducted to investigate feasibility with this ethnic group; a group for which no previous CBT trials have been reported...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29163844/identifying-current-and-remitted-major-depressive-disorder-with-the-hurst-exponent-a-comparative-study-on-two-automated-anatomical-labeling-atlases
#7
Bin Jing, Zhuqing Long, Han Liu, Huagang Yan, Jianxin Dong, Xiao Mo, Dan Li, Chunhong Liu, Haiyun Li
Major depressive disorder (MDD) is a leading world-wide psychiatric disorder with high recurrence rate, therefore, it is desirable to identify current MDD (cMDD) and remitted MDD (rMDD) for their appropriate therapeutic interventions. In the study, 19 cMDD, 19 rMDD and 19 well-matched healthy controls (HC) were enrolled and scanned with the resting-state functional magnetic resonance imaging (rs-fMRI). The Hurst exponent (HE) of rs-fMRI in AAL-90 and AAL-1024 atlases were calculated and compared between groups...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163522/the-vagus-nerve-in-the-neuro-immune-axis-implications-in-the-pathology-of-the-gastrointestinal-tract
#8
REVIEW
Bruno Bonaz, Valérie Sinniger, Sonia Pellissier
The vagus nerve (VN) is the longest nerve of the organism and a major component of the parasympathetic nervous system which constitutes the autonomic nervous system (ANS), with the sympathetic nervous system. There is classically an equilibrium between the sympathetic and parasympathetic nervous systems which is responsible for the maintenance of homeostasis. An imbalance of the ANS is observed in various pathologic conditions. The VN, a mixed nerve with 4/5 afferent and 1/5 efferent fibers, is a key component of the neuro-immune and brain-gut axes through a bidirectional communication between the brain and the gastrointestinal (GI) tract...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163165/the-modulatory-properties-of-chronic-antidepressant-drugs-treatment-on-the-brain-chemokine-chemokine-receptor-network-a-molecular-study-in-an-animal-model-of-depression
#9
Ewa Trojan, Joanna Ślusarczyk, Katarzyna Chamera, Katarzyna Kotarska, Katarzyna Głombik, Marta Kubera, Agnieszka Basta-Kaim
An increasing number of studies indicate that the chemokine system may be the third major communication system of the brain. Therefore, the role of the chemokine system in the development of brain disorders, including depression, has been recently proposed. However, little is known about the impact of the administration of various antidepressant drugs on the brain chemokine - chemokine receptor axis. In the present study, we used an animal model of depression based on the prenatal stress procedure. We determined whether chronic treatment with tianeptine, venlafaxine, or fluoxetine influenced the evoked by prenatal stress procedure changes in the mRNA and protein levels of the homeostatic chemokines, CXCL12 (SDF-1α), CX3CL1 (fractalkine) and their receptors, in the hippocampus and frontal cortex...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163106/recent-advances-in-non-invasive-brain-stimulation-for-major-depressive-disorder
#10
REVIEW
Shui Liu, Jiyao Sheng, Bingjin Li, Xuewen Zhang
Non-invasive brain stimulation (NBS) is a promising treatment for major depressive disorder (MDD), which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) over the prefrontal cortex can play a regulatory role in affective processing. Although the clinical efficacy of NBS in MDD has been demonstrated clinically, the precise mechanism of action remains unclear...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29163031/microrna-mediated-regulation-of-itgb3-and-chl1-is-implicated-in-ssri-action
#11
Keren Oved, Luba Farberov, Avial Gilam, Ifat Israel, Danielle Haguel, David Gurwitz, Noam Shomron
Background: Selective serotonin reuptake inhibitor (SSRI) antidepressant drugs are the first-line of treatment for major depressive disorder (MDD) but are effective in <70% of patients. Our earlier genome-wide studies indicated that two genes encoding for cell adhesion proteins, close homolog of L1 (CHL1) and integrin beta-3 (ITGB3), and microRNAs, miR-151a-3p and miR-221/222, are implicated in the variable sensitivity and response of human lymphoblastoid cell lines (LCL) from unrelated individuals to SSRI drugs...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29163018/brain-networks-implicated-in-seasonal-affective-disorder-a-neuroimaging-pet-study-of-the-serotonin-transporter
#12
Martin Nørgaard, Melanie Ganz, Claus Svarer, Patrick M Fisher, Nathan W Churchill, Vincent Beliveau, Cheryl Grady, Stephen C Strother, Gitte M Knudsen
Background: Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder characterized by seasonally occurring depression that often presents with atypical vegetative symptoms such as hypersomnia and carbohydrate craving. It has recently been shown that unlike healthy people, patients with SAD fail to globally downregulate their cerebral serotonin transporter (5-HTT) in winter, and that this effect seemed to be particularly pronounced in female S-carriers of the 5-HTTLPR genotype. The purpose of this study was to identify a 5-HTT brain network that accounts for the adaption to the environmental stressor of winter in females with the short 5-HTTLPR genotype, a specific subgroup previously reported to be at increased risk for developing SAD...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29162345/postacute-care-after-pediatric-hospitalizations-for-a-primary-mental-health-condition
#13
James C Gay, Bonnie T Zima, Tumaini R Coker, Stephanie K Doupnik, Matthew Hall, Jonathan Rodean, Margaret O'Neill, Rustin Morse, Kris P Rehm, Jay G Berry, Naomi S Bardach
OBJECTIVES: To determine the proportion of US children hospitalized for a primary mental health condition who are discharged to postacute care (PAC); whether PAC discharge is associated with demographic, clinical, and hospital characteristics; and whether PAC use varies by state. STUDY DESIGN: Retrospective cohort study of a nationally representative sample of US acute care hospitalizations for children ages 2-20 years with a primary mental health diagnosis, using the 2009 and 2012 Kids' Inpatient Databases...
November 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29162169/stress-exposure-and-psychopathology-alter-methylation-of-the-serotonin-receptor-2a-htr2a-gene-in-preschoolers
#14
Stephanie H Parade, Andrew M Novick, Justin Parent, Ronald Seifer, Samantha J Klaver, Carmen J Marsit, Asi Polly Gobin, Bao-Zhu Yang, Audrey R Tyrka
Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29161197/acceptance-and-psychological-change-at-the-higher-levels-of-care-a-naturalistic-outcome-study
#15
Keegan Walden, Jamie Manwaring, Dan V Blalock, Emmett Bishop, Alan Duffy, Craig Johnson
This naturalistic outcome study reports on psychological change among a large (N = 617), transdiagnostic sample of eating disordered adults treated at higher levels of care at a private facility. Patients were assessed at admission and discharge for eating disorder psychopathology, depression, personality, and acceptance. Effect sizes ranged from d = .29 to d = 1.29, and the majority of participants (58.2%) were treatment responders, with BN patients showing a higher response rate than AN-R patients. Increased acceptance over the course of treatment was strongly associated with decreased eating disorder risk and may be an important factor in recovery...
November 21, 2017: Eating Disorders
https://www.readbyqxmd.com/read/29161150/cognitive-impairment-in-schizophrenia-and-depression-a-comparison-of-stability-and-course
#16
Peter Neu, Tina Gooren, Ulrike Niebuhr, Peter Schlattmann
Cognitive deficits are clinically relevant features in schizophrenia and depression, yet little comparative data on changes in both disorders is available. This study compares cognitive performance of inpatients with schizophrenia (N = 52) and unipolar major depression (N = 67) during psychiatric treatment, assessing performance twice: after admission to hospital (acute) and prior to discharge (postacute) on average seven weeks later. A group of healthy controls was tested at comparable intervals. Data was analyzed using a multivariate linear model...
November 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29160598/a-randomized-8-week-double-blind-placebo-controlled-trial-of-vortioxetine-in-japanese-adults-with-major-depressive-disorder-followed-by-a-52-week-open-label-extension-trial
#17
Takeshi Inoue, Akira Nishimura, Kiyofumi Sasai, Tadayuki Kitagawa
AIM: Safety and efficacy of vortioxetine (5-20 mg/day) in Japanese patients with major depressive disorder were evaluated in two phase 3 studies consisting of a short-term, 8-week, placebo-controlled, double-blind study followed by a long-term, 52-week, open-label extension study. METHODS: The primary endpoint of the short-term study was change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score at week 8. The primary objective of the extension study was vortioxetine's long-term safety; efficacy endpoints included change in MADRS total score, clinical global impression scale-severity (CGI-S) score from the long-term study baseline, and clinical global impression scale-improvement (CGI-I) score over 52 weeks...
November 21, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29159863/genome-wide-gene-environment-interaction-in-depression-a-systematic-evaluation-of-candidate-genes-the-childhood-trauma-working-group-of-pgc-mdd
#18
Sandra Van der Auwera, Wouter J Peyrot, Yuri Milaneschi, Johannes Hertel, Bernhard Baune, Gerome Breen, Enda Byrne, Erin C Dunn, Helen Fisher, Georg Homuth, Douglas Levinson, Cathryn Lewis, Natalie Mills, Niamh Mullins, Matthias Nauck, Giorgio Pistis, Martin Preisig, Marcella Rietschel, Stephan Ripke, Patrick Sullivan, Alexander Teumer, Henry Völzke, Dorret I Boomsma, Naomi R Wray, Brenda Penninx, Hans Grabe
Gene by environment (GxE) interaction studies have investigated the influence of a number of candidate genes and variants for major depressive disorder (MDD) on the association between childhood trauma and MDD. Most of these studies are hypothesis driven and investigate only a limited number of SNPs in relevant pathways using differing methodological approaches. Here (1) we identified 27 genes and 268 SNPs previously associated with MDD or with GxE interaction in MDD and (2) analyzed their impact on GxE in MDD using a common approach in 3944 subjects of European ancestry from the Psychiatric Genomics Consortium who had completed the Childhood Trauma Questionnaire...
November 21, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29159580/low-left-amygdala-volume-is-associated-with-a-longer-duration-of-unipolar-depression
#19
Maxim Zavorotnyy, Rebecca Zöllner, L R Schulte-Güstenberg, L Wulff, S Schöning, U Dannlowski, H Kugel, V Arolt, C Konrad
The amygdala plays a crucial role in the pathogenesis of major depressive disorder (MDD). While robust findings support a negative impact of illness duration on hippocampal volume in MDD, morphometric studies of the amygdala have yielded inhomogeneous results. Considering the methodical problems of automatic segmentation methods, a standardized segmentation protocol with proven inter- and intra-rater reliability was employed using high-resolution magnetic resonance imaging. To identify the effect of MDD on amygdala morphometry, 23 unipolar depressed patients who responded to antidepressant medication and 30 age-matched healthy controls (HC) were enrolled...
November 20, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29159049/pre-treatment-eeg-signal-variability-is-associated-with-treatment-success-in-depression
#20
Natalia Jaworska, Hongye Wang, Dylan M Smith, Pierre Blier, Verner Knott, Andrea B Protzner
Background: Previous work suggests that major depressive disorder (MDD) is associated with disturbances in global connectivity among brain regions, as well as local connectivity within regions. However, the relative importance of these global versus local changes for successful antidepressant treatment is unknown. We used multiscale entropy (MSE), a measure of brain signal variability, to examine how the propensity for local (fine scale MSE) versus global (coarse scale MSE) neural processing measured prior to antidepressant treatment is related to subsequent treatment response...
2018: NeuroImage: Clinical
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