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https://www.readbyqxmd.com/read/28343281/using-patterns-of-genetic-association-to-elucidate-shared-genetic-etiologies-across-psychiatric-disorders
#1
Seung Bin Cho, Fazil Aliev, Shaunna L Clark, Amy E Adkins, Howard J Edenberg, Kathleen K Bucholz, Bernice Porjesz, Danielle M Dick
Twin studies indicate that latent genetic factors overlap across comorbid psychiatric disorders. In this study, we used a novel approach to elucidate shared genetic factors across psychiatric outcomes by clustering single nucleotide polymorphisms based on their genome-wide association patterns. We applied latent profile analysis (LPA) to p-values resulting from genome-wide association studies across three phenotypes: symptom counts of alcohol dependence (AD), antisocial personality disorder (ASP), and major depression (MD), using the European-American case-control genome-wide association study subsample of the collaborative study on the genetics of alcoholism (N = 1399)...
March 25, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28343067/reading-problems-and-major-mental-disorders-co-occurrences-and-familial-overlaps-in-a-swedish-nationwide-cohort
#2
Martin Cederlöf, Barbara Maughan, Henrik Larsson, Brian M D'Onofrio, Robert Plomin
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings...
March 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28342763/serotonin-and-neuroplasticity-links-between-molecular-functional-and-structural-pathophysiology-in-depression
#3
REVIEW
Christoph Kraus, Eero Castrén, Siegfried Kasper, Rupert Lanzenberger
Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both systems likewise contribute to pathophysiology of depression. Recent findings demonstrate that serotonin reuptake inhibitors trigger reactivation of juvenile-like neuroplasticity. How these findings translate to clinical antidepressant treatment in major depressive disorder remains unclear. With this review, we link preclinical with clinical work on serotonin and neuroplasticity to bring two pathophysiologic models in clinical depression closer together...
March 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28342535/-professional-stressors-and-common-mental-health-disorders-causal-links
#4
C Nicolas, N Chawky, C Jourdan-Ionescu, M-S Drouin, C Page, N Houlfort, G Beauchamp, M Séguin
According to the World Health Organization, depression has become the leading cause of disability in the world, contributing significantly to the burden of health issues especially in the industrialized countries. This is a major public health problem, with potential impact on work climates, productivity at work and the continued existence of the organizations. Some recent studies have examined potential links between professional factors and common mental health disorders, but none have demonstrated a direct causal link...
March 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28342378/elevated-triglyceride-levels-are-associated-with-cognitive-impairments-among-patients-with-major-depressive-disorder
#5
Tian Nan Shao, Guang Zhong Yin, Xiao Li Yin, Jing Qin Wu, Xiang Dong Du, Hong Liang Zhu, Jia Hong Liu, Xiao Qiong Wang, Dong Wu Xu, Wen Jie Tang, Li Hui
BACKGROUND: Cognitive deficits have been identified as one of core clinical symptoms of major depressive disorder (MDD). Accumulating evidence indicated that triglycerides (TG) might be associated with MDD and cognitive decline. OBJECTIVE: This study examined whether patients with MDD had poorer cognitive functions than healthy controls, and further investigate whether TG levels were involved in MDD, and its cognitive impairments in a Han Chinese population. METHOD: 115 patients with MDD and 119 healthy controls were enrolled...
March 14, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28340447/fronto-limbic-disconnection-in-depressed-patients-with-suicidal-ideation-a-resting-state-functional-connectivity-study
#6
Lian Du, Jinkun Zeng, Huan Liu, Dejian Tang, Huaqing Meng, Yongmei Li, Yixiao Fu
BACKGROUND: Suicidal ideation (SI) is highly prevalent and a known symptom of Major Depressive Disorder (MDD), but its underlying biological mechanisms are relatively unknown. Several studies linked suicidal ideation to dysfunctional brain circuits, specifically fronto-limbic connections. The purpose of this work was to investigate fronto-limbic disconnection in MDD patients with or without SI. METHODS: MDD patients with SI (SI, n=28) or without SI (NSI, n=20), identified by the Scale for Suicide Ideation and healthy controls (HCs, n=30) underwent resting-state functional MRI scanning...
February 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340445/an-updated-meta-analysis-short-term-therapeutic-effects-of-repeated-transcranial-magnetic-stimulation-in-treating-obsessive-compulsive-disorder
#7
REVIEW
Dong-Dong Zhou, Wo Wang, Gao-Mao Wang, Da-Qi Li, Li Kuang
BACKGROUND: This study was conducted to evaluate the short-term therapeutic effects of using repeated transcranial magnetic stimulation (rTMS) to treat obsessive-compulsive disorder (OCD) and to examine potential influencing factors. METHOD: We searched the PubMed, EMBASE, CENTRAL, Wanfang, CNKI, and Sinomed databases on September 18, 2016 and reviewed the references of previous meta-analyses. Sham-controlled, randomized clinical trials using rTMS to treat OCD were included...
March 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340443/quantitative-eeg-abnormalities-in-major-depressive-disorder-with-basal-ganglia-stroke-with-lesions-in-different-hemispheres
#8
Chunfang Wang, Yuanyuan Chen, Ying Zhang, Jin Chen, Xiaojing Ding, Dong Ming, Jingang Du
BACKGROUND: This study aimed to examine the aberrant EEG oscillation in major depressive subjects with basal ganglia stroke with lesions in different hemispheres. METHODS: Resting EEG of 16 electrodes in 58 stroke subjects, 26 of whom had poststroke depression (13 with left-hemisphere lesion and 13 with right) and 32 of whom did not (18 with left lesion and 14 with right), was recorded to obtain spectral power analysis for several frequency bands. Multiple analysis of variance and receiver operating characteristic (ROC) curves were used to identify differences between poststroke depression (PSD) and poststroke non-depression (PSND), treating the different lesion hemispheres separately...
February 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340442/neurocognitive-performance-as-an-endophenotype-for-mood-disorder-subgroups
#9
Alison K Merikangas, Lihong Cui, Monica E Calkins, Tyler M Moore, Ruben C Gur, Raquel E Gur, Kathleen R Merikangas
BACKGROUND: There is growing evidence that neurocognitive function may be an endophenotype for mood disorders. The goal of this study is to examine the specificity and familiality of neurocognitive functioning across the full range of mood disorder subgroups, including Bipolar I (BP-I), Bipolar II (BP-II), Major Depressive Disorders (MDD), and controls in a community-based family study. METHODS: A total of 310 participants from 137 families with mood spectrum disorders (n=151) and controls (n=159) completed the University of Pennsylvania's Computerized Neurocognitive Battery (CNB) that assessed the accuracy and speed of task performance across five domains...
March 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28339814/modulating-oxidative-stress-relieves-stress-induced-behavioral-and-cognitive-impairments-in-rats
#10
Naimesh Solanki, Ankita Salvi, Gaurav Patki, Samina Salim
Background: Persistent psychological stress often leads to anxiety disorders and depression. Benzodiazepines and selective serotonin reuptake inhibitors are popular treatment options but have limited efficacy, supporting the need for alternative treatment. Based on our recent preclinical work suggesting a causal link between neurobehavioral deficits and elevated oxidative stress, we hypothesized that interventions that mitigate oxidative stress can attenuate/overcome neurobehavioral deficits...
February 24, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28338954/meta-analysis-of-cerebrospinal-fluid-cytokine-and-tryptophan-catabolite-alterations-in-psychiatric-patients-comparisons-between-schizophrenia-bipolar-disorder-and-depression
#11
Alexandre K Wang, Brian J Miller
INTRODUCTION: Schizophrenia, bipolar disorder, and major depressive disorder (MDD) have all been associated with immune system dysfunction, including aberrant cerebrospinal fluid (CSF) levels of cytokines and tryptophan catabolites; however, the pattern of alterations has not been compared across disorders. We performed a meta-analysis of CSF cytokine and tryptophan catabolites in patients with these major psychiatric disorders. METHODS: Articles were identified by searching Pub Med, PsycInfo, and Web of Science, and the reference lists of these studies...
March 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28338795/-mom-i-don-t-want-to-hear-it-brain-response-to-maternal-praise-and-criticism-in-adolescents-with-major-depressive-disorder
#12
Jennifer S Silk, Kyung Hwa Lee, Rosalind D Elliott, Jill M Hooley, Ronald E Dahl, Anita Barber, Greg J Siegle
Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers' praise, criticism and neutral comments...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28338546/a-double-blind-placebo-controlled-pilot-study-of-riluzole-monotherapy-for-acute-bipolar-depression
#13
Lawrence T Park, Marc S Lener, Matthew Hopkins, Nicolas Iadorola, Rodrigo Machado-Vieira, Elizabeth Ballard, Allison Nugent, Carlos A Zarate
BACKGROUND: Glutamatergic system abnormalities are implicated in the pathophysiology and treatment of both major depressive disorder and bipolar depression (BDep). Subsequent to studies demonstrating the rapid and robust antidepressant effects of ketamine, an N-methyl-D-aspartate receptor antagonist, other glutamatergic modulators are now being studied in clinical trials of mood disorders. A previous open-label study found that riluzole, administered in combination with the mood stabilizer lithium, had antidepressant effects...
March 23, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28338340/serum-interleukin-6-is-related-to-lower-cognitive-functioning-in-elderly-patients-with-major-depression
#14
Nehad Samir Ali, Abdel Hamid Hashem Hashem, Akmal Mostafa Hassan, Alia Adel Saleh, Heba Nabil El-Baz
BACKGROUND: There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD). OBJECTIVES: (1) Assessment of serum IL-6 levels and cognitive functions in elderly patients suffering from major depression and comparing them to healthy age-matched control subjects; (2) correlation between serum IL-6 levels and clinical characteristics of depression and cognitive functions in these patients...
March 24, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28337734/diffusion-tensor-imaging-dti-findings-in-adult-civilian-military-and-sport-related-mild-traumatic-brain-injury-mtbi-a-systematic-critical-review
#15
Breton Michael Asken, Steven T DeKosky, James R Clugston, Michael S Jaffee, Russell M Bauer
This review seeks to summarize diffusion tensor imaging (DTI) studies that have evaluated structural changes attributed to the mechanisms of mild traumatic brain injury (mTBI) in adult civilian, military, and athlete populations. Articles from 2002 to 2016 were retrieved from PubMed/MEDLINE, EBSCOhost, and Google Scholar, using a Boolean search string containing the following terms: "diffusion tensor imaging", "diffusion imaging", "DTI", "white matter", "concussion", "mild traumatic brain injury", "mTBI", "traumatic brain injury", and "TBI"...
March 24, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28337552/clinical-utility-of-resting-state-functional-connectivity-magnetic-resonance-imaging-for-mood-and-cognitive-disorders
#16
REVIEW
T Takamura, T Hanakawa
Although functional magnetic resonance imaging (fMRI) has long been used to assess task-related brain activity in neuropsychiatric disorders, it has not yet become a widely available clinical tool. Resting-state fMRI (rs-fMRI) has been the subject of recent attention in the fields of basic and clinical neuroimaging research. This method enables investigation of the functional organization of the brain and alterations of resting-state networks (RSNs) in patients with neuropsychiatric disorders. Rs-fMRI does not require participants to perform a demanding task, in contrast to task fMRI, which often requires participants to follow complex instructions...
March 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28337525/phosphodiesterase-1b-pde1b-knockout-mice-are-resistant-to-forced-swim-and-tail-suspension-induced-immobility-and-show-upregulation-of-pde10a
#17
Jillian R Hufgard, Michael T Williams, Matthew R Skelton, Olivera Grubisha, Filipa M Ferreira, Helen Sanger, Mary E Wright, Tracy M Reed-Kessler, Kurt Rasmussen, Ronald S Duman, Charles V Vorhees
RATIONALE: Major depressive disorder is a leading cause of suicide and disability. Despite this, current antidepressants provide insufficient efficacy in more than 60% of patients. Most current antidepressants are presynaptic reuptake inhibitors; postsynaptic signal regulation has not received as much attention as potential treatment targets. OBJECTIVES: We examined the effects of disruption of the postsynaptic cyclic nucleotide hydrolyzing enzyme, phosphodiesterase (PDE) 1b, on depressive-like behavior and the effects on PDE1B protein in wild-type (WT) mice following stress...
March 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28336497/intrinsic-disruption-of-white-matter-microarchitecture-in-first-episode-drug-naive-major-depressive-disorder-a-voxel-based-meta-analysis-of-diffusion-tensor-imaging
#18
REVIEW
Guangxiang Chen, Yi Guo, Hongyan Zhu, Weihong Kuang, Feng Bi, Hua Ai, Zhongwei Gu, Xiaoqi Huang, Su Lui, Qiyong Gong
Previous studies have demonstrated the influences of episodes and antidepressant drugs on white matter (WM) in patients with major depressive disorder (MDD). However, most diffusion tensor imaging (DTI) studies included highly heterogeneous individuals with different numbers of depressive episodes or medication status. To exclude the confounding effects of multiple episodes or medication, we conducted a quantitative voxel-based meta-analysis of fractional anisotropy (FA) in patients with first-episode, drug-naive MDD to identify the intrinsic WM alterations involved in the pathogenesis of MDD...
March 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28335624/effects-of-patient-preferences-on-outcomes-in-the-predictors-of-remission-in-depression-to-individual-and-combined-treatments-predict-study
#19
Boadie W Dunlop, Mary E Kelley, Vivianne Aponte-Rivera, Tanja Mletzko-Crowe, Becky Kinkead, James C Ritchie, Charles B Nemeroff, W Edward Craighead, Helen S Mayberg
OBJECTIVE: The Predictors of Remission in Depression to Individual and Combined Treatments [PReDICT] study aimed to identify clinical and biological factors predictive of treatment outcomes in major depressive disorder among treatment-naive adults. The authors evaluated the efficacy of cognitive-behavioral therapy (CBT) and two antidepressant medications (escitalopram and duloxetine) in patients with major depression and examined the moderating effect of patients' treatment preferences on outcomes...
March 24, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28335622/functional-connectivity-of-the-subcallosal-cingulate-cortex-and-differential-outcomes-to-treatment-with-cognitive-behavioral-therapy-or-antidepressant-medication-for-major-depressive-disorder
#20
Boadie W Dunlop, Justin K Rajendra, W Edward Craighead, Mary E Kelley, Callie L McGrath, Ki Sueng Choi, Becky Kinkead, Charles B Nemeroff, Helen S Mayberg
OBJECTIVE: The purpose of this article was to inform the first-line treatment choice between cognitive-behavioral therapy (CBT) or an antidepressant medication for treatment-naive adults with major depressive disorder by defining a neuroimaging biomarker that differentially identifies the outcomes of remission and treatment failure to these interventions. METHOD: Functional MRI resting-state functional connectivity analyses using a bilateral subcallosal cingulate cortex (SCC) seed was applied to 122 patients from the Prediction of Remission to Individual and Combined Treatments (PReDICT) study who completed 12 weeks of randomized treatment with CBT or antidepressant medication...
March 24, 2017: American Journal of Psychiatry
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