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Altitude medicine

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https://www.readbyqxmd.com/read/29772916/home-oxygen-therapy-for-bronchiolitis-an-evaluation-of-the-primary-care-providers-experience-at-sea-level
#1
Erin E Dunbar, Michelle L Macy, James A Cranford, Nicole Sroufe, Marie Lozon, Marisa C Louie
Despite 90% of primary care providers at altitude reporting experience with home oxygen therapy for hypoxemic, otherwise well infants, its use at sea level is not well described. Our objective was to understand experience with home oxygen at sea level and determine potential barriers and benefits of its use. We surveyed all pediatricians and family medicine providers within a 30-mile radius of our pediatric hospital from May 2016 to December 2016. Forty-three percent of providers responded. Few (8%) had any experience with home oxygen therapy for bronchiolitis...
May 1, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/29768543/preventing-diseases-in-round-the-world-travelers-a-contemporary-challenge-for-travel-medicine-advice
#2
Karis Maria de Pinho Rodrigues, Beatriz Meurer Moreira
Providing advice for travelers embarking on long-term trips poses a challenge in travel medicine. A long duration of risk exposure is associated with underuse of protective measures and poor adherence to chemoprophylaxis, increasing the chances of acquiring infections. Recently, in our clinic, we observed an increase in the number of travelers undertaking round-the-world trips. These individuals are typically aged around 32 years and quit their jobs to embark on one-to-two-year journeys. Their destinations include countries in two or more continents, invariably Southeast Asia and Indonesia, and mostly involve land travel and visiting rural areas...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29751123/high-altitude-species-high-profits-can-the-trade-in-wild-harvested-fritillaria-cirrhosa-liliaceae-be-sustained
#3
REVIEW
A B Cunningham, J A Brinckmann, S-J Pei, P Luo, U Schippmann, X Long, Y-F Bi
ETHNOPHARMACOLOGICAL RELEVANCE: Fritillaria cirrhosa D. Don bulbs contain alkaloids and are one of the most intensively exploited alpine Himalayan medicinal species. In terms of proprietary medicines, our study shows that 210 F. cirrhosa products are offered by 46 suppliers, most of which (44) are situated in China and two in Nepal. A widepread commercial use is as one of the main ingredients in cough syrups. A well known example is "Nin Jiom Pei Pa Koa Herbal Cough & Throat Syrup", which typically contains more F...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29728134/ethnobotany-of-the-sierra-nevada-del-cocuy-g%C3%A3-ic%C3%A3-n-climate-change-and-conservation-strategies-in-the-colombian-andes
#4
Mireia Alcántara Rodríguez, Andrea Angueyra, Antoine M Cleef, Tinde Van Andel
BACKGROUND: The Sierra Nevada del Cocuy-Güicán in the Colombian Andes is protected as a National Natural Park since 1977 because of its fragile páramo ecosystems, extraordinary biodiversity, high plant endemism, and function as water reservoir. The vegetation on this mountain is threatened by expanding agriculture, deforestation, tourism, and climate change. We present an ethnobotanical inventory among local farmer communities and discuss the effects of vegetation change on the availability of useful plants...
May 5, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29701197/-role-of-drug-transporters-in-rational-use-of-drugs-at-high-altitude-area
#5
Wenbin Li, Baohua Yan, Rong Wang, Zhengping Jia
Pharmacokinetics plays a key role in rational use of medicines. Many factors can affect the drug's pharmacokinetics. Previous studies mainly focused on the impact of hypoxia on hepatic drug metabolizing enzyme, but uncommon on drug transporters. Actually, drug transporter is a key factor for activation of the drugs transport across the cell membrane into the inside of cells, such as multidrug resistance protein (MDR), breast cancer resistance protein (BCRP), multidrug resistance associated protein (MRP), organic cation transporter (OCT), organic anion-transporting polypeptide (OATP), organic anion transporter (OAT), qligopeptide transporter (PEPT), etc...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29657371/comparison-of-optic-nerve-sheath-diameter-between-both-eyes-a-bedside-ultrasonography-approach
#6
Uday Yanamandra, Amul Gupta, Srinivasa A Bhattachar, Sushma Yanamandra, Subrat K Das, Sagarika Patyal, Rajan Grewal, Velu Nair
Context: Optic nerve sheath diameter (ONSD) has long been accepted as a reliable proxy of intracranial pressure especially in critical care and bedside settings. The present consensus is to measure ONSD in both eyes and take average value, which is cumbersome and a potential cause of discomfort to the patient. Aim: We aim to compare the values of ONSD of the right and left eye in a random sample as measured by bedside ocular ultrasonography (USG) in Indian adults...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29620950/a-systematic-review-and-meta-analysis-reveals-altered-drug-pharmacokinetics-in-humans-during-acute-exposure-to-terrestrial-high-altitude-clinical-justification-for-dose-adjustment
#7
Damian Miles Bailey, Benjamin S Stacey, Mark Gumbleton
OBJECTIVE: While physiological responses during acute ascent to terrestrial high altitude (HA) have the potential to alter the pharmacokinetics (PKs) that define absorption and disposition of medicinal drugs, there have been no systematic reviews and meta-analyses performed to date. METHODS: We conducted a systematic literature search in June 2017 using NCBI PubMed, EMBASE, Web of Science, and Ovid MEDLINE databases to identify relevant observational studies. Studies were deemed eligible based on the following criteria: (1) participants: healthy, nonacclimatized male or female lowlanders (born and bred at sea level) and (2) environment: exposure to low altitude (LA, ≤600 m), followed by terrestrial high altitude (HA, ≤24 hours to ≥2500 m), the time course specifically selected to avoid interpretive complications associated with erythrocytosis...
April 5, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29596018/the-star-data-reporting-guidelines-for-clinical-high-altitude-research
#8
Monika Brodmann Maeder, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Bärtsch, Erik R Swenson, Ken Zafren
Brodmann Maeder, Monika, Hermann Brugger, Matiram Pun, Giacomo Strapazzon, Tomas Dal Cappello, Marco Maggiorini, Peter Hackett, Peter Baärtsch, Erik R. Swenson, Ken Zafren (STAR Core Group), and the STAR Delphi Expert Group. The STARdata reporting guidelines for clinical high altitude research. High AltMedBiol. 19:7-14, 2018. AIMS: The goal of the STAR (STrengthening Altitude Research) initiative was to produce a uniform set of key elements for research and reporting in clinical high-altitude (HA) medicine...
March 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29583031/the-2018-lake-louise-acute-mountain-sickness-score
#9
Robert C Roach, Peter H Hackett, Oswald Oelz, Peter Bärtsch, Andrew M Luks, Martin J MacInnis, J Kenneth Baillie
Roach, Robert C., Peter H. Hackett, Oswald Oelz, Peter Bärtsch, Andrew M. Luks, Martin J. MacInnis, J. Kenneth Baillie, and The Lake Louise AMS Score Consensus Committee. The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol 00:000-000, 2018.- The Lake Louise Acute Mountain Sickness (AMS) scoring system has been a useful research tool since first published in 1991. Recent studies have shown that disturbed sleep at altitude, one of the five symptoms scored for AMS, is more likely due to altitude hypoxia per se, and is not closely related to AMS...
March 13, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29581383/high-altitude-arterialised-capillary-earlobe-blood-gas-measurement-using-the-abbott-i-stat
#10
Christopher T Lewis, W L Malein, Ian Chesner, S Clarke
INTRODUCTION: Measurement of physiological parameters in extreme environments is essential to advancing knowledge, prophylaxis and treatment of altitude sickness. Point-of-care testing facilitates investigation in non-specialist and remote settings, as well as becoming increasingly popular at the bedside for real-time results in the clinical environment. Arterialised capillary earlobe blood gases are recommended as a valid alternative to arterial sampling in research. This study aimed to test the feasibility of obtaining and analysing daily earlobe samples at high altitude...
March 25, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29551642/quality-markers-of-animal-medicinal-materials-correlative-analysis-of-musk-reveals-distinct-metabolic-changes-induced-by-multiple-factors
#11
Zhi-Shu Tang, Yan-Ru Liu, Yang Lv, Jin-Ao Duan, Shi-Zhong Chen, Jing Sun, Zhong-Xing Song, Xiao-Min Wu, Li Liu
BACKGROUND: Common farming environmental elements, such as longitude, latitude, and altitude, and physiological conditions, such as age and body weight, are thought to influence medicinal animal homeostasis and material quality by altering endocrine functions for primary and secondary metabolite formation. However, the currently available methods for evaluating complex components of traditional Chinese animal medicines have insufficient sensitivity and specificity. PURPOSE: Characterizing the primary/secondary metabolomes of medicinal animals is essential for understanding their material basis, controlling product quality, and reflecting on distribution interactions...
March 6, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29545281/pulmonary-vascular-endothelium-orchestra-conductor-in-respiratory-diseases-highlights-from-basic-research-to-therapy
#12
REVIEW
Alice Huertas, Christophe Guignabert
The European Respiratory Society (ERS) Research Seminar entitled " Pulmonary Vascular Endothelium: Orchestra Conductor in Respiratory Diseases - Highlights from Basic Research to Therapy " brought together international experts of dysfunctional pulmonary endothelium, from basic science to translational medicine, to discuss several important aspects in acute and chronic lung diseases. This review will briefly sum up the different topics of discussion of this meeting held in Paris (France) on October 27th and 28th, 2016...
March 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29538546/sleep-characteristics-in-an-adult-with-sleep-complaints-in-three-cities-at-different-altitudes
#13
Julio Cesar Castellanos-Ramírez, Alvaro J Ruíz, Patricia Hidalgo-Martínez, Liliana Otero-Mendoza
Sleep studies conducted at an altitude that is different from the home altitude can yield misleading results regarding the severity of obstructive sleep apnea (OSA). The objective of the present study was to determine the sleep characteristics of a patient undergoing polysomnography (PSG) in three Colombian cities at different altitudes (Bogotá, at 2,640 m above sea level [ASL]; Bucaramanga, at 959 m ASL; and Santa Marta, at 15 m ASL). The patient was an obese man with diabetes and suspected OSA. All PSG recordings were scored and interpreted in accordance with American Academy of Sleep Medicine criteria...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29474899/high-altitude-organic-gold-the-production-network-for-ophiocordyceps-sinensis-from-far-western-nepal
#14
Mariève Pouliot, Dipesh Pyakurel, Carsten Smith-Hall
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (Berk.) G.H.Sung, J.M.Sung, Hywel-Jones & Spatafora, a high altitude Himalayan fungus-caterpillar product found in alpine meadows in China, Bhutan, Nepal, and India, has been used in the Traditional Chinese Medicine system for over 2000 years. Heightened demand in China over the past 15 years, coupled with limited production, has led to a price hike and increased economic importance of harvests to rural households throughout the species' range...
May 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29430358/comparative-de-novo-transcriptome-analysis-of-male-and-female-sea-buckthorn
#15
Ankush Bansal, Mehul Salaria, Tashil Sharma, Tsering Stobdan, Anil Kant
Sea buckthorn is a dioecious medicinal plant found at high altitude. The plant has both male and female reproductive organs in separate individuals. In this article, whole transcriptome de novo assemblies of male and female flower bud samples were carried out using Illumina NextSeq 500 platform to determine the role of the genes involved in sex determination. Moreover, genes with differential expression in male and female transcriptomes were identified to understand the underlying sex determination mechanism...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29425650/antihypoxic-activities-of-constituents-from-arenaria-kansuensis
#16
Yulei Cui, Yanduo Tao, Lei Jiang, Na Shen, Shuo Wang, Huaixiu Wen, Zenggen Liu
BACKGROUND: In previous investigation, we have identified antioxidative effects of water-soluble ethanolic extracts (named as AKE) from Arenaria kansuensis and inferred that these extracts or their constituents may also have antihypoxic activity. A. kansuensis has been widely used in traditional Tibetan medicine for altitude sickness (AS) and has been known as the herb of anti-inflammatory and hypoxia resistance for a long time. PURPOSE: The purpose of this study is to evaluate protective effects of AKE and its major constituents against hypoxia-induced lethality in mice and RSC96 cells...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29376253/-chemical-constituents-biological-activities-and-clinical-applications-of-artemisia-rupestris
#17
Ying-Jie Wan, Jian-Xin Xia, Li Tang
Artemisia rupestris is a traditional medicine in Uygur and Kazak in Xinjiang Province, mainly distributed in the territory of Xinjiang Altai area, Tianshan mountains and the Kunlun mountains, growing at an altitude of 1 500 to 4 000 meters of grassland and forest areas. As the broad research on chemical constituents, pharmacological activity, the effective components of A. rupestris have attracted the interest to make up new drugs. Based on the latest research from A. rupestris, identification and geographic distribution, chemical constituents, pharmacological effects, clinical applications were summarized in this article, in the view of Medicinal Ethnobotany...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29333043/picroside-i-and-picroside-ii-from-tissue-cultures-of-picrorhiza-kurroa
#18
Yamjala Ganeshkumar, Ajmera Ramarao, Ciddi Veeresham
Background: Picrorhiza kurroa (PK) belongs to Scrophulariaceae family and is a representative endemic, medicinal herb, widely distributed throughout the higher altitudes of alpine Himalayas from west to east, between 3000 and 4500 m above mean sea level. Objective: The objective of the present study is to assess the production of picroside I and picroside II from tissue cultures of PK. Materials and Methods: Auxiliary shoot tips of PK were incubated in Murashige and Skoog medium supplemented with indole-3-butyric acid and kinetin phytohormones...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29318840/-application-of-remote-sensing-and-gis-in-study-of-suitability-distribution-of-swertia-mussotii-a-tibetan-medicine-in-sichuan-province
#19
Yong-Bo Dong, Yao Luo, Cong Zhu, Wen-Fu Peng, Xin-Liang Xu, Qing-Mao Fang
Swertia mussotii is a kind of rare medicinal materials, the relevant researches are mainly concentrated on its medicinal efficacy and medicinal value till now, researches of adaptive distribution by applying remote sensing and GIS are relatively less. This study is to analyze the adaptive distribution of S.mussotii in Sichuan province by applying remote sensing and GIS technology, and provide scientific basis for the protection and development of wild resources, artificial cultivation and adjustment of Chinese medicine industrial distribution in Sichuan province...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318839/-research-on-suitable-distribution-of-paris-yunnanensis-based-on-remote-sensing-and-gis
#20
Yao Luo, Yong-Bo Dong, Cong Zhu, Wen-Fu Peng, Qing-Mao Fang, Xin-Liang Xu
Paris yunnanensis is a kind of rare medicinal herb, having a very high medicinal value. Studying its suitable ecological condition can provide a basis for its rational exploitation, artificial cultivation, and sustainable utilization. A practicable method in this paper has been proposed to research the suitable regional distribution of P. yunnanensis in Sichuan province. By the case study of P. yunnanensis in Sichuan province, and according to related literatures, the suitable ecological condition of P. yunnanensis such as altitude, mean annual temperature (MAT), annual precipitation, regional slope, slope ranges, vegetative cover, and soil types was analyzed following remote sensing (RS) and GIS...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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