keyword
https://read.qxmd.com/read/38547195/elevator-block-brake-structural-optimization-design-based-on-an-approximate-model
#1
JOURNAL ARTICLE
Haijian Wang, Chengwen Yu, Xishan Zhu, Liu Jian, Congcong Lu, Xiaoguang Pan
An Aquila optimizer-back propagation (AO-BP) neural network was used to establish an approximate model of the relationship between the design variables and the optimization objective to improve elevator block brake capabilities and achieve a lightweight brake design. Subsequently, the constraint conditions and objective functions were determined. Moreover, the multi-objective genetic algorithm optimized the structural block brake design. Finally, the effectiveness of the optimization results was verified using simulation experiments...
2024: PloS One
https://read.qxmd.com/read/38547163/effect-of-compassion-fatigue-on-emotional-labor-in-female-nurses-moderating-effect-of-self-compassion
#2
JOURNAL ARTICLE
Li-Chuan Chu
UNLABELLED: Emotional labor is common in nursing but may be affected by the mental state of nurses. This study explored the effect of compassion fatigue on emotional labor and whether self-compassion moderates this effect of compassion fatigue. METHODS: A two-stage survey design with a convenience sample. Participants were female nursing staff recruited from emergency departments, intensive care units, ward nursing units, and outpatient departments of medical centers, regional hospitals, and district hospitals in Taiwan...
2024: PloS One
https://read.qxmd.com/read/38547107/rheological-properties-of-warm-mixed-high-viscosity-asphalt-at-high-and-low-temperatures
#3
JOURNAL ARTICLE
Jun'an Lei, Nanxiang Zheng, Yuanyuan Wang, Haicheng Su, Xiaofeng Ren, Fujing Zhao
The rheological properties of asphalt can well reflect its road performance, but the rheological properties of warm mix high viscosity asphalt (HVA) are unclear. In order to study the effect of warm mixing agent on rheological properties of HVA, two kinds of warm mixing agent EC120 (EC) and Evotherm M1 (M1) were selected to prepare warm mix HVA. The rheological properties of warm mix HVA at high temperature (135~195°C), medium temperature (0~80°C) and low temperature (-6~18°C) were studied by Brinell rotary viscosity test, dynamic shear rheological test (including temperature scanning, frequency scanning, linear amplitude scanning) and bending beam rheological test...
2024: PloS One
https://read.qxmd.com/read/38546381/thrombopoietin-receptor-agonists-and-other-second-line-therapies-for-immune-thrombocytopenia-a-narrative-review-with-a-focus-on-drug-access-in-canada
#4
JOURNAL ARTICLE
Joanne Britto, Anne Holbrook, Haowei Sun, Christine Cserti-Gazdewich, Oksana Prokopchuk-Gauk, Cyrus Hsia, Karima Khamisa, Paul R Yenson, Michelle Sholzberg, Harold J Olney, Sudeep Shivakumar, David Jones, Hayley Merkeley, Jacqueline Costello, Erin Jamula, Donald M Arnold
INTRODUCTION: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts and increased risk of bleeding. After corticosteroids with or without intravenous immune globulin (first-line treatment), second-line treatment options include rituximab, splenectomy, thrombopoietin receptor agonists (TPO-RAs), and fostamatinib. In Canada, the choice of second-line therapy is influenced by access to medications. The goals of this narrative review are to 1) summarize the evidence for the use of TPO-RAs and other second-line therapies in ITP and 2) highlight differences in public funding criteria for TPO-RAs across provinces and territories in Canada...
March 1, 2024: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://read.qxmd.com/read/38546309/vitamin-c-and-d-deficiency-in-urban-america-a-case-report
#5
JOURNAL ARTICLE
Alyssa A Lombardi, Maura Sammon, Kraftin E Schreyer
INTRODUCTION: Scurvy is caused by vitamin C deficiency and manifests with a variety of symptoms including generalized fatigue, apathy, anemia, myalgias, easy bruising, and poor wound healing. It is generally thought of as a disease of the past, especially in developed countries. However, vitamin C deficiency still occurs, especially in patients with lack of access to fruits and vegetables. Other micronutrient deficiencies, including vitamin D deficiency, are also prevalent and can cause a multitude of signs and symptoms including osteomalacia, muscle weakness, and increased risk of many chronic illnesses...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546220/safety-efficacy-and-biological-data-of-t-cell-enabling-oncolytic-adenovirus-tilt-123-in-advanced-solid-cancers-from-the-tunimo-monotherapy-phase-i-trial
#6
JOURNAL ARTICLE
Santeri A Pakola, Katriina J Peltola, James H A Clubb, Elise Jirovec, Lyna Haybout, Tatiana V Kudling, Tuomo Alanko, Riitta Korpisaari, Susanna Juteau, Marjut Jaakkola, Jorma Sormunen, Jukka Kemppainen, Annabrita Hemmes, Teijo Pellinen, Mirte van der Heijden, Dafne C A Quixabeira, Claudia Kistler, Suvi Sorsa, Riikka Havunen, Joao M Santos, Victor Cervera-Carrascon, Akseli E Hemminki
PURPOSE: TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with tumor necrosis factor alpha and interleukin-2, designed to induce T-cell infiltration and cytotoxicity in solid tumors. PATIENTS AND METHODS: TUNIMO (NCT04695327) was a single-arm, multicenter phase I dose escalation trial designed to assess safety of TILT-123 in advanced solid cancers refractory to standard therapy. Patients received intravenous and intratumoral TILT-123. The primary endpoint was safety by adverse events (AEs), laboratory values, vital signs, and electrocardiograms...
March 28, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38546148/musculoskeletal-pain-intensity-and-perceptions-during-distance-learning-a-cross-sectional-study
#7
JOURNAL ARTICLE
Burak Şevket Vuran, Turgay Altunalan
Technological developments and the pandemic have popularized the distance learning model at universities. In this educational model, students spend more time in front of screens, and screen-related health conditions have become important. This cross-sectional study of 177 undergraduate students was designed to investigate the effect of block and traditional scheduling in online distance education (ODE) on their musculoskeletal pain and to investigate their perceptions of block scheduling. A two-stage method was used: a quantitative design to compare pain levels, and a qualitative design to determine the students' perceptions of block scheduling using an online survey...
March 28, 2024: Clinical Anatomy
https://read.qxmd.com/read/38545799/exploring-sexual-function-in-adrenal-insufficiency-findings-from-the-dual-release-hydrocortisone-versus-conventional-glucocorticoid-replacement-therapy-in-hypocortisolism-dream-trial
#8
JOURNAL ARTICLE
Valeria Hasenmajer, Dario De Alcubierre, Davide Ferrari, Marianna Minnetti, Ilaria Bonaventura, Riccardo Pofi, Chiara Simeoli, Alessandra Tomaselli, Francesca Sciarra, Grazia Bottillo, Francesco Angelini, Alessia Cozzolino, Mary Anna Venneri, Emmanuele A Jannini, Daniele Gianfrilli, Rosario Pivonello, Andrea M Isidori
BACKGROUND: Data on sexual function in patients with adrenal insufficiency are scarce and largely controversial. OBJECTIVES: To investigate sexual dysfunction in patients with primary and secondary adrenal insufficiency and the effects of switching to once-daily dual-release hydrocortisone on sexual function in outcome assessors blinded, randomized, multicenter, active comparator clinical trial. MATERIALS AND METHODS: Eighty-nine adrenal insufficiency patients on conventional, multiple daily doses of glucocorticoid replacement, enrolled in the Dual RElease hydrocortisone versus conventionAl glucocorticoid replaceMent in hypocortisolism (DREAM) trial, were randomly assigned to continue their therapy or to switch to an equivalent dose of dual-release hydrocortisone...
March 28, 2024: Andrology
https://read.qxmd.com/read/38545759/a-longitudinal-study-of-symptom-cluster-latent-profiles-in-ovarian-cancer-patients-undergoing-chemotherapy
#9
JOURNAL ARTICLE
Yue Feng, Tangwei Lin, Xingcan Liu, Xiujing Guo, Jing Chen, Xue Deng
BACKGROUND: This study aimed to identify distinct patterns within the symptom cluster of fatigue, pain, and sleep disturbance among ovarian cancer patients receiving chemotherapy, to determine the factors predicting these patterns and their impact on quality of life. METHODS: The longitudinal study collected data from 151 ovarian cancer patients at three time points: before chemotherapy (T0), after the first chemotherapy cycle (T1), and following the completion of four cycles of chemotherapy (T2)...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38545697/implementing-systematic-patient-reported-measures-for-chronic-conditions-through-the-naveta-value-based-telemedicine-initiative-results-of-an-observational-retrospective-and-multicenter-study
#10
JOURNAL ARTICLE
Gabriel Mercadal-Orfila, Salvador Herrera-Pérez, Núria Piqué, Francesc Mateu-Amengual, Pedro Ventayol-Bosch, María Antonia Maestre-Fullana, Joaquín Ignacio Serrano-López de Las Hazas, Francisco Fernández-Cortés, Francesc Barceló-Sansó, Santiago Rios
BACKGROUND: Patient-reported outcome and experience measures can play a critical role in providing patient-centered and value-based healthcare to a growing population of chronically ill patients. Value-based telemedicine platforms such as the Naveta initiative may facilitate the effective integration of these tools into healthcare systems. OBJECTIVE: This study aims to evaluate the response rate to electronic patient-reported outcome measures (ePROMs) and electronic patient-reported experience measures (ePREMs) among patients participating in the Naveta telemedicine initiative, its correlations with sociodemographic and clinical characteristics, and the evolution of the rates over time...
March 27, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38545654/a-longitudinal-framework-to-describe-the-relation-between-age-related-hearing-loss-and-social-isolation
#11
JOURNAL ARTICLE
Aysha Motala, Ingrid S Johnsrude, Björn Herrmann
Many older adults live with some form of hearing loss and have difficulty understanding speech in the presence of background sound. Experiences resulting from such difficulties include increased listening effort and fatigue. Social interactions may become less appealing in the context of such experiences, and age-related hearing loss is associated with an increased risk of social isolation and associated negative psychosocial health outcomes. However, the precise relationship between age-related hearing loss and social isolation is not well described...
2024: Trends in Hearing
https://read.qxmd.com/read/38545336/teleyoga-for-patients-with-alzheimer-s-disease-and-chronic-musculoskeletal-pain-and-their-caregivers-a-feasibility-study
#12
JOURNAL ARTICLE
Santiago Allende, Louise Mahoney, Jasmin M Francisco, Korrine Fitz, Audrey Keaney, Kelly Parker-Bridges, Heidi Mahoney, Booil Jo, Jason Greenberg, Peter J Bayley
BACKGROUND: Chronic musculoskeletal pain is common in patients with Alzheimer's disease (AD), and there is growing awareness that chronic pain has an impact on the progression of dementia. Yoga has shown promise in treating chronic pain. However, attending in-person yoga can be difficult for AD patients. OBJECTIVE: To assess the feasibility, acceptability and preliminary efficacy of an online yoga (teleyoga) protocol suitable for AD patients with chronic pain, and their caregivers...
2024: Glob Adv Integr Med Health
https://read.qxmd.com/read/38545317/severity-of-menopausal-symptoms-on-quality-of-life-among-working-women
#13
S Ramyashree, Jacintha Veigas, Deepa Kanagal
BACKGROUND: Menopause is experienced by every woman; some women attain it very early as they reach 42 years old. This happens when there is a dysfunction of follicles. The symptoms experienced by the women vary from mild to severe. The study aims to identify the severity of menopausal symptoms and their effect on the quality of life (QOL) among working women. MATERIALS AND METHODS: A cross-sectional research design was used for the study. A total of 93 menopausal working women were selected by using the nonprobability sampling technique...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38545281/do-people-with-me-cfs-and-joint-hypermobility-represent-a-disease-subgroup-an-analysis-using-registry-data
#14
JOURNAL ARTICLE
Kathleen Mudie, Allison Ramiller, Sadie Whittaker, Leslie E Phillips
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally. Despite its significant impact, the disease's etiology remains poorly understood, and symptom heterogeneity poses challenges for diagnosis and treatment. Joint hypermobility, commonly seen in hypermobile Ehlers-Danlos Syndrome (hEDS), has been observed in ME/CFS patients but its prevalence and clinical significance within this population are not well-characterized...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38545166/continuous-monitoring-of-body-temperature-for-objective-detection-of-health-and-safety-risks-in-construction-sites-an-analysis-of-the-accuracy-and-comfort-of-off-the-shelf-wearable-sensors
#15
JOURNAL ARTICLE
Farnad Nasirzadeh, Chandan Karmakar, Ahsan Habib, Kevin Benny Neelangal, Mostafa Mir, SangHyun Lee, Tony Arnel
Recent studies have shown the potential of wearable sensors for objective detection of health and safety risks in construction workers through their collected physiological data. Body temperature, as the focus of the current study, is one of the most important physiological parameters that can help to detect various health and safety risks such as heat stress, physical fatigue, and infectious diseases. This study aims to assess the applicability and performance of off-the-shelf wearable sensor devices to monitor workers' body temperature in construction sites by evaluating the accuracy of temperature measurements as well as the comfort of the devices...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545117/-acanthopanax-senticosus-improves-cognitive-impairment-in-alzheimer-s-disease-by-promoting-the-phosphorylation-of-the-mapk-signaling-pathway
#16
JOURNAL ARTICLE
Zhichun Zhang, Yonghui Wu, Dan Shi, Chanyu Jiang, Hengyan Cao, Fengyi Jiang, Xiaomin Bao, Yan Shen, Xiao Shi
BACKGROUND: Acanthopanax senticosus (AS) can improve sleep, enhance memory, and reduce fatigue and is considered as an effective drug for Alzheimer's disease (AD). The therapeutic effect and mechanism need to be further investigated. METHODS: To confirm the AS play efficacy in alleviating memory impairment in mice, 5×FAD transgenic mice were subjected to an open-field experiment and a novelty recognition experiment. Network pharmacology technique was used to analyze the information of key compounds and potential key targets of AS for the treatment of AD, molecular docking technique was applied to predict the binding ability of targets and compounds, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were also performed on the targets to derive the possible metabolic processes and pathway mechanisms of AS in treating AD...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545050/a-deep-learning-based-automatic-image-quality-assessment-method-for-respiratory-phase-on-computed-tomography-chest-images
#17
JOURNAL ARTICLE
Jialin Su, Meifang Li, Yongping Lin, Liu Xiong, Caixing Yuan, Zhimin Zhou, Kunlong Yan
BACKGROUND: Computed tomography (CT) chest scans have become commonly used in clinical diagnosis. Image quality assessment (IQA) for CT images plays an important role in CT examination. It is worth noting that IQA is still a manual and subjective process, and even experienced radiologists make mistakes due to human limitations (fatigue, perceptual biases, and cognitive biases). There are also kinds of biases because of poor consensus among radiologists. Excellent IQA methods can reliably give an objective evaluation result and also reduce the workload of radiologists...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38544955/psychological-factors-may-affect-the-quality-of-life-in-irritable-bowel-syndrome-patients-more-than-the-gut-itself-a-multicenter-cross-sectional-study
#18
JOURNAL ARTICLE
Xiaotian Xie, Jing He, Shu Xu, Zhiyue Xu, Yanqin Long, Zhijun Duan, Jie Yang, Zhifeng Zhang, Jun Wu, Lianying Cai, Liexin Liang, Ning Dai, Jun Zhang, Tao Bai, Xiaohua Hou
BACKGROUND AND AIM: Both intestinal symptoms and comorbidities exist in irritable bowel syndrome (IBS) patients and influence their quality of life (QOL). More research is needed to determine how these variables impact the QOL of IBS patients. This study aimed to determine which specific factors had a higher influence on QOL and to further compare the effects of intestinal symptoms and comorbidities on QOL. METHODS: IBS patients were recruited from six tertiary hospitals in different regions of China...
March 2024: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/38544841/patient-reported-outcomes-in-hodgkin-lymphoma-trials-a-systematic-review
#19
Esther Natalie Oliva, Tatyana Ionova, Edward Laane, Mario Csenar, Julia Schroer, Karolin Behringer, Ina Monsef, Annika Oeser, Nicole Skoetz, Sam Salek
BACKGROUND: Lymphoma treatment can lead to long-term consequences such as fatigue, infertility and organ damage. In clinical trials, survival outcomes, clinical response and toxicity are extensively reported while the assessment of treatment on quality of life (QoL) and symptoms is often lacking. OBJECTIVE: We evaluated the use and frequency of patient-reported outcome (PRO) instruments used in randomized controlled trials (RCTs) for Hodgkin lymphoma (HL) and their consistency of reporting...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544721/how-is-inflammation-biology-truly-associated-with-depression-in-patients-with-stable-coronary-heart-disease-insights-from-the-heart-and-soul-study
#20
JOURNAL ARTICLE
Chiyoung Lee, Mary Whooley, Qing Yang, Daniel P Moriarity
Depression is known to be associated with inflammation among patients with established coronary heart disease (CHD), but it is unclear whether this is due to individual depression symptoms or to the broader construct of depression. We addressed this gap by using moderated non-linear factor analysis (MNLFA) to determine the extent that inflammation is associated with latent depression and/or individual symptoms in this patient group. We evaluated 1,024 outpatients with stable CHD from the baseline cross-sectional data of the Heart and Soul Study...
May 2024: Brain, behavior, & immunity health
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