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Qiang Shi, Zheng Meng, Jun-Feng Xiang, Chuan-Feng Chen
The movement of three pairs of different non-photoresponsive rotaxanes can be efficiently controlled by visible light through a photo-induced proton-transfer (PIPT) strategy in the presence of the photoacid 1-MEH. Moreover, the PIPT strategy also provides systems with a good fatigue resistance after more than 50 cycles.
March 22, 2018: Chemical Communications: Chem Comm
Vikas Ostwal, Rohit Swami, Shraddha Patkar, Swaratika Majumdar, Mahesh Goel, Shaesta Mehta, Reena Engineer, Sarika Mandavkar, Suman Kumar, Anant Ramaswamy
Data on adjuvant chemotherapy with gemcitabine-cisplatin (GC) in resected gallbladder cancers (GBC) are scarce. Patients who underwent upfront curative resection for GBC from 2010 to 2016 were analyzed. Patients with stage II-III GBC treated with adjuvant GC were analyzed. A total of 242 patients were evaluated, of whom 125 patients received GC regimen as adjuvant chemotherapy. The median age was 50 years (range 31-74), majority were female (77.6%), and 37 patients (29.6%) had raised CA 19.9 levels at baseline...
March 21, 2018: Medical Oncology
Shangjin Song, Jiahui Yu, Yi Ruan, Xuan Liu, Lijuan Xiu, Xiaoqiang Yue
PURPOSE: This meta-analysis investigated the effectiveness of Tai Chi on cancer-related fatigue (CRF). METHODS: Nine databases (PubMed, Web of Science, Ovid, the Cochrane Library, Embase, and four Chinese databases) were searched to identify randomized controlled trials (RCTs) that evaluated the effects of Tai Chi on CRF. The reference lists given in the identified RCTs were also reviewed to identify potentially relevant studies. RESULTS: Six RCTs involving 373 patients were included...
March 21, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Bruno Fautrel, Rieke Alten, Bruce Kirkham, Inmaculada de la Torre, Frederick Durand, Jane Barry, Thorsten Holzkaemper, Walid Fakhouri, Peter C Taylor
Current guidelines for the management of rheumatoid arthritis (RA) recommend early treatment and a treat-to-target goal of remission or low disease activity. Over the past decade, this approach has been extremely successful in reducing disease activity and joint damage in patients with RA. At the same time, however, overall patient perception of well-being appears to have decreased with respect to outcome measures considered important by patients themselves, such as pain, fatigue, physical function and quality of life...
March 21, 2018: Rheumatology International
Abdulbari Bener, Reem Alsulaiman, Lisa Doodson, Hanadi R El Ayoubi
Introduction: Breast cancer has been the most common cancer type that affects women worldwide and subsequent treatment is often associated with considerable psychological and quality of life (QoL). Aim: This study aimed to assess psychometric properties of the Arabic version of the European Organization for Research and Treatment of Cancer (EORTC) general QoL questionnaire (QLQ-C30) for breast cancer patients in Qatar. Materials and Methods: This is a cross-sectional hospital-based study conducted on 678 breast cancer patients using Arabic version of the EORTC QLQ-C30 tool...
October 2017: Journal of Family Medicine and Primary Care
Mahnaz Fallahi Khesht-Masjedi, Somayeh Shokrgozar, Elahe Abdollahi, Mahbuobe Golshahi, Zahra Sharif-Ghaziani
Introduction: Symptoms of depression vary between the males and females. Depressed men show behaviors such as irritability, restlessness, difficulty in concentrating, and instead of the usual behaviors. Sleep disturbance is a common symptom in depressed men. Men are less likely to go to doctors and unconsciously show other behaviors such as anger instead of the sadness. It seems that considering depression as "feminine" is a great injustice toward male patients whom their illness will not be diagnosed nor treated...
October 2017: Journal of Family Medicine and Primary Care
William H Jin, Eric A Mellon, Jessica M Frakes, Gilbert Z Murimwa, Pamela J Hodul, Jose M Pimiento, Mokenge P Malafa, Sarah E Hoffe
Background: Total psoas area (TPA), a marker of sarcopenia, has been used as an independent predictor of clinical outcomes in gastrointestinal (GI) cancers as a proxy for frailty and nutritional status. Our study aimed to evaluate whether TPA, in contrast to traditional measurements of nutrition like body mass index (BMI) and body surface area (BSA), was predictive of outcomes in borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) patients receiving stereotactic body radiation therapy (SBRT)...
February 2018: Journal of Gastrointestinal Oncology
Reem Jarrad, Sawsan Hammad, Tagreed Shawashi, Naser Mahmoud
Aim: This study aimed to detect if there were differences in compassion fatigue (CF) among nurses based on substance use and demographic variables of gender, marital status, type of health institution and income. Background: Compassion fatigue is considered an outcome of poorly handled stressful situations in which nurses may respond with self-harming behaviours like substance use. Evidence in this area is critically lacking. Methods: This study used a descriptive design to survey differences in CF of 282 nurses...
2018: Annals of General Psychiatry
Stephanie Weber, Christian Puta, Melanie Lesinski, Brunhild Gabriel, Thomas Steidten, Karl-Jürgen Bär, Marco Herbsleb, Urs Granacher, Holger H W Gabriel
Elite young athletes have to cope with multiple psychological demands such as training volume, mental and physical fatigue, spatial separation of family and friends or time management problems may lead to reduced mental and physical recovery. While normative data regarding symptoms of anxiety and depression for the general population is available (Hinz and Brähler, 2011), hardly any information exists for adolescents in general and young athletes in particular. Therefore, the aim of this study was to assess overall symptoms of anxiety and depression in young athletes as well as possible sex differences...
2018: Frontiers in Physiology
Karel Lietaert, Antonio Cutolo, Dries Boey, Brecht Van Hooreweder
Mechanical performance of additively manufactured (AM) Ti6Al4V scaffolds has mostly been studied in uniaxial compression. However, in real-life applications, more complex load conditions occur. To address this, a novel sample geometry was designed, tested and analyzed in this work. The new scaffold geometry, with porosity gradient between the solid ends and scaffold middle, was successfully used for quasi-static tension, tension-tension (R = 0.1), tension-compression (R = -1) and compression-compression (R = 10) fatigue tests...
March 21, 2018: Scientific Reports
Andreas Pabst, Juan Carlos Castillo-Duque, Axel Mayer, Marcus Klinghuber, Richard Werkmeister
In the past two decades, the synthetic style and fashion drug "crystal meth" ("crystal", "meth"), chemically representing the crystalline form of the methamphetamine hydrochloride, has become more and more popular in the United States, in Eastern Europe, and just recently in Central and Western Europe. "Meth" is cheap, easy to synthesize and to market, and has an extremely high potential for abuse and dependence. As a strong sympathomimetic, "meth" has the potency to switch off hunger, fatigue and, pain while simultaneously increasing physical and mental performance...
October 30, 2017: Dent J (Basel)
Leora Horn, Jeffrey R Infante, Karen L Reckamp, George R Blumenshein, Ticiana A Leal, Saiama N Waqar, Barbara J Gitlitz, Rachel E Sanborn, Jennifer G Whisenant, Liping Du, Joel W Neal, Jon P Gockerman, Gary Dukart, Kimberly Harrow, Chris Liang, James J Gibbons, Allison Holzhausen, Christine M Lovly, Heather A Wakelee
PURPOSE: Evaluate safety and determine the recommended phase II dose (RP2D) of ensartinib (X-396), a potent anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), and evaluate preliminary pharmacokinetics and antitumor activity in a first-in-human, phase I/II clinical trial primarily in patients with non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: In dose escalation, ensartinib was administered at doses of 25-250 mg once daily in patients with advanced solid tumors; in dose expansion, patients with advanced ALK-positive NSCLC were administered 225 mg once daily...
March 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Lora J Wu, Philippa H Gander, Margo van den Berg, T Leigh Signal
BACKGROUND: Many civilian aviation regulators favor evidence-based strategies that go beyond hours-of-service approaches for managing fatigue risk. Several countries now allow operations to be flown outside of flight and duty hour limitations, provided airlines demonstrate an alternative method of compliance that yields safety levels "at least equivalent to" the prescriptive regulations. Here we discuss equivalence testing in occupational fatigue risk management. We present suggested ratios/margins of practical equivalence when comparing operations inside and outside of prescriptive regulations for two common aviation safety performance indicators: total in-flight sleep duration and psychomotor vigilance task reaction speed...
April 1, 2018: Aerospace Medicine and Human Performance
Carolyn E Wilshire, Tom Kindlon, Robert Courtney, Alem Matthees, David Tuller, Keith Geraghty, Bruce Levin
BACKGROUND: The PACE trial was a well-powered randomised trial designed to examine the efficacy of graded exercise therapy (GET) and cognitive behavioural therapy (CBT) for chronic fatigue syndrome. Reports concluded that both treatments were moderately effective, each leading to recovery in over a fifth of patients. However, the reported analyses did not consistently follow the procedures set out in the published protocol, and it is unclear whether the conclusions are fully justified by the evidence...
March 22, 2018: BMC Psychology
David B Zhen, Rachel L McDevitt, Mark M Zalupski, Vaibhav Sahai
Irinotecan (Camptosar© , CPT-11), a topoisomerase I inhibitor, is a commonly used cytotoxic chemotherapeutic in the treatment of multiple malignancies, particularly of gastrointestinal origin. Dysarthria secondary to irinotecan has been described as a rare side effect in a few case reports with limited data to recommend appropriate management. We describe herein a large single institution experience of patients with gastrointestinal malignancies who experienced dysarthria while being treated with irinotecan-based chemotherapy regimens (FOLFIRINOX or FOLFIRI+/-bevacizumab)...
January 1, 2018: Journal of Oncology Pharmacy Practice
Jorge M Serrador, Karen S Quigley, Caixia Zhao, Thomas Findley, Benjamin H Natelson
OBJECTIVE: Chronic Fatigue Syndrome (CFS) is a disorder of unknown etiology associated with debilitating fatigue. One symptom commonly reported is disequilibrium. The goal of this study was to determine if CFS patients demonstrated verified balance deficits and if this was effected by comorbid fibromyalgia (FM). METHODS: Twenty-seven patients with CFS (12 with comorbid FM) and 22 age and gender matched controls performed posturography. RESULTS: Balance scores were significantly correlated with physical functional status in the CFS group (R2 = 0...
2018: NeuroRehabilitation
Jacob Callesen, Davide Cattaneo, John Brincks, Ulrik Dalgas
INTRODUCTION: Multiple sclerosis (MS) is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Progressive resistance training (PRT) has proven to be a promising intervention showing a positive effect on muscle strength. Another promising intervention frequently used in neuro-rehabilitation is task specific training where also Balance and Motor Control Training (BMCT) are incorporated...
2018: NeuroRehabilitation
M Saffari, A H Pakpour, F Al Zaben, H G Koenig
BACKGROUND: Chronic hepatitis B (CHB) is a serious and prevalent disease which may negatively influence health related quality of life (HRQOL) and fatigue. The aim of the present study was to examine the relationship between demographic variables, HRQOL, and fatigue. METHODS: A cross-sectional study was conducted involving 418 Iranian patients with CHB (average age 44.1 years, majority males). Participants completed a multidimensional fatigue inventory, chronic liver disease questionnaire, Euro quality of life-five dimensions questionnaire, and demographic information...
April 2017: Acta Gastro-enterologica Belgica
Ha-Yoon Choi, Hee-Jun Han, Ji-Won Choi, Han-Young Jung, Kyung-Lim Joa
Objective: To evaluate the effect of high-intensity interval training (HIIT) on psychological symptoms, activity states, and cardiovascular functions in patients with myocardial infarction (MI) of low and moderate risk stratification. Methods: This prospective study randomly allocated 44 patients with MI to 18 sessions of HIIT or conventional moderate-intensity continuous training (MICT). Outcome measures were assessed at baseline and after 18 sessions. Results: Post-exercise cardiovascular and functional states, maximal oxygen uptake (VO2max ), metabolic equivalents (METs), 6-Minute Walking Test (6MWT), and Korean Activity Scale/Index (KASI) scores were significantly improved in the HIIT group compared to those in the MICT group after 18 exercise sessions...
February 2018: Annals of Rehabilitation Medicine
Amir Emami Zeydi, Hossein Karimi Moonaghi, Abbas Heydari
Background: Despite the clinical importance of adherence to treatment in β-Thalassemia Major (β-TM) patients, poor adherence remains a prevalent and persistent problem in these patients. Objective: The aim of this study was to explore Iranian β-TM patients' perception regarding the barriers and facilitators of adherence to their treatments. Methods: In this qualitative study, data were collected using purposeful sampling and semi-structured interviews with 18 β-TM patients, 3 family members and 5 healthcare professionals (total=26) in Sari, northern Iran, between August 2015 and May 2017...
December 2017: Electronic Physician
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