Read by QxMD icon Read


V A Reva, Y Matsumura, T Hörer, D A Sveklov, A V Denisov, S Y Telickiy, A B Seleznev, E R Bozhedomova, J Matsumoto, I M Samokhvalov, J J Morrison
PURPOSE: The aim of this study is to evaluate the early survival and organ damage following 30 and 60 min of thoracic resuscitative endovascular balloon occlusion of the aorta (REBOA) in an ovine model of severe hemorrhagic shock. METHODS: Eighteen sheep were induced into shock by undergoing a 35 % controlled exsanguination over 30 min. Animals were randomized into three groups: 60-min REBOA 30 min after the bleeding (60-REBOA), 30-min REBOA 60 min after the bleeding (30-REBOA) and no-REBOA control (n-REBOA)...
October 13, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Jeremy Ming Hsu, Shilpi Yadev, Shadi Faraj
INTRODUCTION: Exsanguinating pelvic fractures are still associated with a significant mortality rate of 28-60%. Extraperitoneal pelvic packing (EPP) has been proposed as an optimal method of early haemorrhage control. The aim of this study was to determine the effect of EPP compared with angioembolization as a primary intervention for patients with exsanguinating pelvic fracture. METHOD: A prospective observational trial was performed at Westmead Hospital between September 2011 and May 2014...
July 2016: International Journal of Critical Illness and Injury Science
Yong Wang, Hongwei Chen, Diangang Han, Ying Chen, Gemingguli Muhatai, Tursunjan Kurban, Jinming Xing, Jianzhong He
The adipocyte-type fatty acid-binding protein (A-FABP) is considered a candidate gene for fat metabolism; thus, it affects fat deposition in chickens. The present study was designed to examine the polymorphism and mRNA abundance of the A-FABP gene with intramuscular fat (IMF) in the pectoralis muscles (PM) and leg muscles (LM) of Three-yellow Chicken (TYC) and Hetian-black Chicken (HTBC). In total, 60 TYCs and 60 HTBCs were sacrificed using exsanguination at market age. The IMF contents of the PM and LM in the HTBC were significantly higher than those in the TYC...
August 10, 2016: Animal Biotechnology
Jeffrey Steinberg, Vincent Cheung, Gunjan Goel, J Scott Pannell, Javan Nation, Alexander Khalessi
Although there have been reports of carotid artery pseudoaneurysm formation after adenoidectomy and/or tonsillectomy secondary to iatrogenic injury, there are no case reports of successful endovascular reconstruction of the injured artery in the pediatric population. In most pediatric cases, the internal carotid artery (ICA) is sacrificed. The authors report on a 6-year-old girl who presented with odynophagia, left-sided Horner's syndrome, hematemesis, and severe anemia 6 months after a tonsillectomy. On examination she was found to have a pulsatile mass along the left posterior lateral oropharynx, and imaging demonstrated a dissection of the extracranial left ICA and an associated pseudoaneurysm...
September 30, 2016: Journal of Neurosurgery. Pediatrics
Niteen Tapuria, Sameer Junnarkar, Mahmoud Abu-Amara, Barry Fuller, Alexander M Seifalian, Brian R Davidson
AIM: To investigate the hepatic microcirculatory changes due to Haemoxygenase (HO), effect of HO inhibition on remote ischemic preconditioning (RIPC) and modulation of CINC. METHODS: Eight groups of animals were studied - Sham, ischemia reperfusion injury (IRI) the animals were subjected to 45 min of hepatic ischemia followed by three hours of reperfusion, RIPC (remote ischemic preconditioning) + IRI group, remote ischemic preconditioning in sham (RIPC + Sham), PDTC + IR (Pyridodithiocarbamate, HO donor), ZnPP + RIPC + IRI (Zinc protoporphyrin prior to preconditioning), IR-24 (45 min of ischemia followed by 24 h of reperfusion), RIPC + IR-24 (preconditioning prior to IR)...
September 7, 2016: World Journal of Gastroenterology: WJG
Nicholas S Clarke, Raghav Murthy, Jennifer Hernandez, Steve Megison, Kristine J Guleserian
Exsanguinating hematemesis secondary to an aortoesophageal fistula from an impacted foreign body occurred in a patient with a vascular ring. This report describes successful resuscitation and repair in a 6-year-old boy who was transferred from an outside hospital in extremis with an aortoesophageal fistula from a foreign body in the presence of a vascular ring.
October 2016: Annals of Thoracic Surgery
S E van Oostendorp, E C T H Tan, L M G Geeraedts
INTRODUCTION: Exsanguination following trauma is potentially preventable. Extremity tourniquets have been successfully implemented in military and civilian prehospital care. Prehospital control of bleeding from the torso and junctional area's remains challenging but offers a great potential to improve survival rates. This review aims to provide an overview of potential treatment options in both clinical as preclinical state of research on truncal and junctional bleeding. Since many options have been developed for application in the military primarily, translation to the civilian situation is discussed...
2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Mats J Johansson, John-Peder Escobar Kvitting, Torun Flatebø, Anne Nicolaysen, Gunnar Nicolaysen, Sten M Walther
BACKGROUND: Local formation of nitric oxide in the lung induces vasodilation in proportion to ventilation and is a putative mechanism behind ventilation-perfusion matching. We hypothesized that regional ventilation-perfusion matching occurs in part due to local constitutive nitric oxide formation. METHODS: Ventilation and perfusion were analyzed in lung regions (≈1.5 cm) before and after inhibition of constitutive nitric oxide synthase with N-nitro-L-arginine methyl ester (L-NAME) (25 mg/kg) in 7 prone sheep ventilated with 10 cm H2O positive end-expiratory pressure...
September 12, 2016: Anesthesia and Analgesia
Vincent J Mase, Janet L Roe, Robert J Christy, Michael A Dubick, Thomas J Walters
BACKGROUND: The widespread application of tourniquets has reduced battlefield mortality related to extremity exsanguinations. Tourniquet-induced ischemia-reperfusion injury (I/R) can contribute to muscle loss. Postischemic conditioning (PostC) confers protection against I/R in cardiac muscle and skeletal muscle flaps. The objective of this study was to determine the effect of PostC on extremity muscle viability in an established rat hindlimb tourniquet model. METHODS: Rats were randomly assigned to PostC-1, PostC-2, or no conditioning ischemic groups (n = 10 per group)...
April 16, 2016: American Journal of Emergency Medicine
R N Verma, Shahbaz Hasnain, D K Sreevastava, T V S P Murthy
BACKGROUND: Intravenous regional anaesthesia (IVRA) has been successfully used as a sole technique for forearm fractures and has high success rates. However, it is uncomfortable for the patient when the fresh fracture is manipulated for conduct of IVRA. Haematoma block (HB) has also been demonstrated as an effective anaesthetic technique for treatment of radial fractures in the ER. Unfortunately, HB does not provide muscular relaxation and may not be sufficient for operative intervention...
July 2016: Medical Journal, Armed Forces India
C F Sun, S G Wang, Y G Peng, Y Shi, Y P Du, G X Shi, T Wen, Y K Wang, H Su
OBJECTIVE: To investigate the effects of different drugs on systolic blood pressure (SBP) and left ventricular hypertrophy (LVH) in spontaneously hypertensive rats under cold stress. METHODS: A total of 40 male spontaneously hypertensive rats aged 10 weeks (160~200 g) were given adaptive feeding for 7 days at a temperature of 20±1°C and then randomly divided into control group, cold stress group, metoprolol group, amlodipine group, and benazepril group, with 8 rats in each group...
June 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Lonnie Froberg, Frederik Helgstrand, Caroline Clausen, Jacob Steinmetz, Henrik Eckardt
OBJECTIVE: Exsanguination due to coagulopathy and vascular injury is a common cause of death among trauma patients. Arterial injury can be treated either by angiography and embolization or by explorative laparotomy and surgical packing. The purpose of this study was to compare 30-day mortality and blood product consumption in trauma patients with active arterial haemorrhage in the abdominal and/or pelvic region treated with either angiography and embolization or explorative laparotomy and surgical packing...
July 2016: Journal of Emergencies, Trauma, and Shock
R Rudolf
In 1718, French surgeon Jean-Louis Petit refined the methods to prevent haemorrhage from severely injured limbs by a combined screw and pad attached to a bandage (Kirkup, 2007). He named this device tourniquet (from French tourner = to turn), because the screw allowed fine adjustment of the application without moving the bandage component. Since then, tourniquet has undergone several modifications and its use is a matter of constant debate. Tourniquets serve primarily in combat but also in civilian emergency medicine to prevent fatal exsanguination and an estimated number of 15,000 daily tourniquet applications (McEwen and Casey, 2009) illustrates its present clinical relevance...
August 6, 2016: Acta Physiologica
Joonas Tirkkonen, Heidi Hellevuo, Klaus T Olkkola, Sanna Hoppu
AIM: Aetiology of in-hospital cardiac arrests (IHCAs) on general wards has not been studied. We aimed to determine the underlying causes for IHCAs by the means of autopsy records and clinical judgement of the treating consultants. Furthermore, we investigated whether aetiology and preceding vital dysfunctions are associated with long-term survival. DESIGN AND SETTING: Prospective observational study between 2009-2011 including 279 adult IHCA patients attended by medical emergency team in a Finnish university hospital's general wards...
October 2016: Resuscitation
Burcu Bakır, Zuhal Yetkin Ay, H İbrahim Büyükbayram, Duygu Kumbul Doğuç, Dilek Bayram, I Aydın Candan, Ersin Uskun
BACKGROUND: Curcumin has anti-inflammatory and antioxidant effects and is reported to have several biological activities. Hence, the current study examined the effect of curcumin on the systemic Th17 response, on the gingival expression of IL-17 and retinoic acid receptor-related orphan receptor (RORγt), and on alveolar bone loss (ABL) in experimental periodontitis. METHODS: Thirty-eight male albino Wistar rats were divided into four groups: Group 1: periodontitis; Group 2: periodontitis with curcumin treatment; Group 3: periodontally healthy with curcumin treatment; Group 4: periodontally healthy...
July 23, 2016: Journal of Periodontology
Thomas Peponis, Elie Ramly, Kym A Roth, David R King
BACKGROUND: Chemical, biological, radiological, and nuclear threats (CBRNs) are uncommon; however, Special Operations Forces (SOF) are likely at the highest risk for tactical exposure. In the event of exposure, SOF will rely on the Joint Service Lightweight Integrated Suit Technology (JSLIST) for survival. Doctrine dictates that a tourniquet should be applied over the JSLIST after a severe limb injury with hemorrhage. There is no evidence in the literature that the Combat Application Tourniquet (C-A-T), which is currently the most widely available tourniquet on the battlefield, can effectively occlude arterial blood flow when applied over the JSLIST...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
James J Morrison, Yama Kharoti, Khashayar Farsad
No abstract text is available yet for this article.
August 2016: Journal of Vascular and Interventional Radiology: JVIR
Jung Keun Lee, Thomas Graham Rosser, Jim Cooley
The current report describes the use of a molecular technique to identify immature Fascioloides magna An 18-month-old Brangus heifer was found dead in the field without any prior clinical signs. The cause of death was exsanguination into the thoracic cavity associated with pulmonary embolization and infection by immature Fascioloides magna resulting in 2 large foci of pulmonary necrosis and focal arteriolar and lung rupture. The liver had a few random migratory tracts with typical iron and porphyrin fluke exhaust, but no identified fluke larvae...
September 2016: Journal of Veterinary Diagnostic Investigation
N Anitha, S Ganesh Kamath, Edison Khymdeit, Manjunath Prabhu
Although insertion of chest drain tubes is a common medical practice, there are risks associated with this procedure, especially when inexperienced physicians perform it. Wrong insertion of the tube has been known to cause morbidity and occasional mortality. We report a case where the left ventricle was accidentally punctured leading to near-exsanguination. This report is to highlight the need for experienced physicians to supervise the procedure and train the younger physician in the safe performance of the procedure...
July 2016: Annals of Cardiac Anaesthesia
Samy Sadek, David J Lockey, Robbie A Lendrum, Zane Perkins, Jonathan Price, Gareth Edward Davies
This report describes the first use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in the pre-hospital setting to control catastrophic haemorrhage. The patient, who had fallen 15 meters, suffered catastrophic internal haemorrhage associated with a pelvic fracture. He was treated by London's Air Ambulance's Physician-Paramedic team. This included insertion of a REBOA balloon catheter at the scene to control likely fatal exsanguination. The patient survived transfer to hospital, emergency angio-embolization and subsequent surgery...
October 2016: Resuscitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"