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https://www.readbyqxmd.com/read/29783850/the-utility-of-anti-inflammatory-agents-in-cardiovascular-disease-a-novel-perspective-on-the-treatment-of-atherosclerosis
#1
Santhosh J Kottoor, Rohit R Arora
Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical and experimental data suggest that inflammation plays an important role in atherothrombosis independent of the cholesterol level. Acute-phase reactants, such as C-reactive protein, increase in patients with coronary artery disease and are known to predict adverse outcomes in such patients...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29742381/mri-targeted-versus-ultrasonography-guided-biopsy-for-suspected-prostate-cancer
#2
EDITORIAL
Michael J Barry, Andrew B Rosenkrantz
New England Journal of Medicine, Volume 378, Issue 19, Page 1835-1836, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742380/idiopathic-pulmonary-fibrosis
#3
REVIEW
David J Lederer, Fernando J Martinez
New England Journal of Medicine, Volume 378, Issue 19, Page 1811-1823, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742376/essential-tremor
#4
REVIEW
Dietrich Haubenberger, Mark Hallett
New England Journal of Medicine, Volume 378, Issue 19, Page 1802-1810, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742375/investigational-testing-for-zika-virus-among-u-s-blood-donors
#5
MULTICENTER STUDY
Paula Saá, Melanie Proctor, Gregory Foster, David Krysztof, Colleen Winton, Jeffrey M Linnen, Kui Gao, Jaye P Brodsky, Ronald J Limberger, Roger Y Dodd, Susan L Stramer
BACKGROUND: Because of the potential severe clinical consequences of Zika virus (ZIKV) infection, the large numbers of asymptomatic travelers returning from ZIKV-active areas, the detection of ZIKV nucleic acid in blood, and reports of transmission of ZIKV through transfusion, in 2016 the Food and Drug Administration released recommendations for individual-unit nucleic acid testing to minimize the risk of transmission of ZIKV through blood transfusions. METHODS: The American Red Cross implemented investigational screening of donated blood for ZIKV RNA by means of transcription-mediated amplification (TMA)...
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742371/moving-on
#6
Abigail Zuger
New England Journal of Medicine, Volume 378, Issue 19, Page 1763-1765, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742369/xanthoma-striatum-palmare
#7
Viktoria F Koehler, Klaus G Parhofer
New England Journal of Medicine, Volume 378, Issue 19, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742367/tackling-tumors-with-small-rnas-derived-from-transfer-rna
#8
Frank J Slack
New England Journal of Medicine, Volume 378, Issue 19, Page 1842-1843, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29742366/trypanosoma-cruzi-reactivation-in-the-brain
#9
Carlos A Gomez, Niaz Banaei
New England Journal of Medicine, Volume 378, Issue 19, Page 1824-1824, May 2018.
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29733448/real-world-evidence-what-it-is-and-what-it-can-tell-us-according-to-the-international-society-for-pharmacoepidemiology-ispe-comparative-effectiveness-research-cer-special-interest-group-sig
#10
Hongbo Yuan, M Sanni Ali, Emily S Brouwer, Cynthia J Girman, Jeff J Guo, Jennifer L Lund, Elisabetta Patorno, Jonathan L Slaughter, Xuerong Wen, Dimitri Bennett
On December 8, 2016, the New England Journal of Medicine published a sounding board on Real World Evidence (RWE)1 by the US Food and Drug Administration (FDA) leadership. While the value of RWE based on nonrandomized observational studies was appreciated, such as for hypothesis generating, safety, and measuring quality in healthcare delivery, the authors expressed concerns on the quality of data sources and the ability of methodologies to control for confounding. In response, we offer a few considerations regarding these concerns...
May 7, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29694370/bayesian-reanalysis-of-null-results-reported-in-medicine-strong-yet-variable-evidence-for-the-absence-of-treatment-effects
#11
Rink Hoekstra, Rei Monden, Don van Ravenzwaaij, Eric-Jan Wagenmakers
Efficient medical progress requires that we know when a treatment effect is absent. We considered all 207 Original Articles published in the 2015 volume of the New England Journal of Medicine and found that 45 (21.7%) reported a null result for at least one of the primary outcome measures. Unfortunately, standard statistical analyses are unable to quantify the degree to which these null results actually support the null hypothesis. Such quantification is possible, however, by conducting a Bayesian hypothesis test...
2018: PloS One
https://www.readbyqxmd.com/read/29669233/scleral-discoloration-from-minocycline-treatment
#12
Jawad Arshad, Rony Sayegh
New England Journal of Medicine, Volume 378, Issue 16, Page 1537-1537, April 2018.
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669232/relationship-between-clinic-and-ambulatory-blood-pressure-measurements-and-mortality
#13
MULTICENTER STUDY
José R Banegas, Luis M Ruilope, Alejandro de la Sierra, Ernest Vinyoles, Manuel Gorostidi, Juan J de la Cruz, Gema Ruiz-Hurtado, Julián Segura, Fernando Rodríguez-Artalejo, Bryan Williams
BACKGROUND: Evidence for the influence of ambulatory blood pressure on prognosis derives mainly from population-based studies and a few relatively small clinical investigations. This study examined the associations of blood pressure measured in the clinic (clinic blood pressure) and 24-hour ambulatory blood pressure with all-cause and cardiovascular mortality in a large cohort of patients in primary care. METHODS: We analyzed data from a registry-based, multicenter, national cohort that included 63,910 adults recruited from 2004 through 2014 in Spain...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669230/ecg-pattern-associated-with-left-anterior-descending-coronary-artery-occlusion
#14
Yun-Tao Zhao, Yen-Shu Huang
New England Journal of Medicine, Volume 378, Issue 16, April 2018.
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669229/gene-therapy-as-a-curative-option-for-%C3%AE-thalassemia
#15
EDITORIAL
Alessandra Biffi
New England Journal of Medicine, Volume 378, Issue 16, Page 1551-1552, April 2018.
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669227/the-value-in-an-ambulatory-blood-pressure-registry
#16
EDITORIAL
Raymond R Townsend
New England Journal of Medicine, Volume 378, Issue 16, Page 1555-1556, April 2018.
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669226/gene-therapy-in-patients-with-transfusion-dependent-%C3%AE-thalassemia
#17
Alexis A Thompson, Mark C Walters, Janet Kwiatkowski, John E J Rasko, Jean-Antoine Ribeil, Suradej Hongeng, Elisa Magrin, Gary J Schiller, Emmanuel Payen, Michaela Semeraro, Despina Moshous, Francois Lefrere, Hervé Puy, Philippe Bourget, Alessandra Magnani, Laure Caccavelli, Jean-Sébastien Diana, Felipe Suarez, Fabrice Monpoux, Valentine Brousse, Catherine Poirot, Chantal Brouzes, Jean-François Meritet, Corinne Pondarré, Yves Beuzard, Stany Chrétien, Thibaud Lefebvre, David T Teachey, Usanarat Anurathapan, P Joy Ho, Christof von Kalle, Morris Kletzel, Elliott Vichinsky, Sandeep Soni, Gabor Veres, Olivier Negre, Robert W Ross, David Davidson, Alexandria Petrusich, Laura Sandler, Mohammed Asmal, Olivier Hermine, Mariane De Montalembert, Salima Hacein-Bey-Abina, Stéphane Blanche, Philippe Leboulch, Marina Cavazzana
BACKGROUND: Donor availability and transplantation-related risks limit the broad use of allogeneic hematopoietic-cell transplantation in patients with transfusion-dependent β-thalassemia. After previously establishing that lentiviral transfer of a marked β-globin (βA-T87Q ) gene could substitute for long-term red-cell transfusions in a patient with β-thalassemia, we wanted to evaluate the safety and efficacy of such gene therapy in patients with transfusion-dependent β-thalassemia...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669225/placenta-accreta-spectrum
#18
REVIEW
Robert M Silver, D Ware Branch
New England Journal of Medicine, Volume 378, Issue 16, Page 1529-1536, April 2018.
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29669224/evaluation-of-intussusception-after-monovalent-rotavirus-vaccination-in-africa
#19
Jacqueline E Tate, Jason M Mwenda, George Armah, Bhavin Jani, Richard Omore, Ayesheshem Ademe, Hilda Mujuru, Evans Mpabalwani, Bagrey Ngwira, Margaret M Cortese, Richard Mihigo, Hope Glover-Addy, Mwajabu Mbaga, Francis Osawa, Amezene Tadesse, Bothwell Mbuwayesango, Julia Simwaka, Nigel Cunliffe, Benjamin A Lopman, Goitom Weldegebriel, Daniel Ansong, David Msuya, Billy Ogwel, Thomas Karengera, Portia Manangazira, Bruce Bvulani, Catherine Yen, Felicitas R Zawaira, Clement T Narh, Lazaro Mboma, Peter Saula, Fasil Teshager, Halle Getachew, Rebecca M Moeti, Christabel Eweronu-Laryea, Umesh D Parashar
BACKGROUND: Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries. METHODS: Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29668475/rare-renal-disease-in-macedonia-an-update
#20
Velibor Tasic, Zoran Gucev, Momir Polenakovic
Rare renal diseases (RRD) are an important category of rare disease (RD) as they can do great damage to the patients, families and society. The patient may undergo years even decades of numerous investigations including invasive procedures and yet not have definitive and precise diagnose and therefore, no opportunity for appropriate treatment. The great progress in molecular genetic techniques characterized many Mendelian diseases on molecular level. This gave the possibility for appropriate prevention and treatment interventions, genetic counseling and prenatal diagnosis...
December 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
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